-- dump date 20140619_134112 -- class Genbank::misc_feature -- table misc_feature_note -- id note 932920000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 932920000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 932920000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920000004 Walker A motif; other site 932920000005 ATP binding site [chemical binding]; other site 932920000006 Walker B motif; other site 932920000007 arginine finger; other site 932920000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 932920000009 DnaA box-binding interface [nucleotide binding]; other site 932920000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 932920000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 932920000012 putative DNA binding surface [nucleotide binding]; other site 932920000013 dimer interface [polypeptide binding]; other site 932920000014 beta-clamp/clamp loader binding surface; other site 932920000015 beta-clamp/translesion DNA polymerase binding surface; other site 932920000016 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 932920000017 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 932920000018 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 932920000019 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 932920000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 932920000021 Walker A/P-loop; other site 932920000022 ATP binding site [chemical binding]; other site 932920000023 Q-loop/lid; other site 932920000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920000025 ABC transporter signature motif; other site 932920000026 Walker B; other site 932920000027 D-loop; other site 932920000028 H-loop/switch region; other site 932920000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 932920000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920000031 Mg2+ binding site [ion binding]; other site 932920000032 G-X-G motif; other site 932920000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 932920000034 anchoring element; other site 932920000035 dimer interface [polypeptide binding]; other site 932920000036 ATP binding site [chemical binding]; other site 932920000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 932920000038 active site 932920000039 putative metal-binding site [ion binding]; other site 932920000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 932920000041 DNA gyrase subunit A; Validated; Region: PRK05560 932920000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 932920000043 CAP-like domain; other site 932920000044 active site 932920000045 primary dimer interface [polypeptide binding]; other site 932920000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932920000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932920000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932920000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932920000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932920000051 cardiolipin synthetase; Reviewed; Region: PRK12452 932920000052 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 932920000053 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 932920000054 putative active site [active] 932920000055 catalytic site [active] 932920000056 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 932920000057 putative active site [active] 932920000058 catalytic site [active] 932920000059 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 932920000060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920000061 Coenzyme A binding pocket [chemical binding]; other site 932920000062 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 932920000063 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 932920000064 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 932920000065 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 932920000066 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 932920000067 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 932920000068 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 932920000069 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 932920000070 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 932920000071 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 932920000072 D-pathway; other site 932920000073 Putative ubiquinol binding site [chemical binding]; other site 932920000074 Low-spin heme (heme b) binding site [chemical binding]; other site 932920000075 Putative water exit pathway; other site 932920000076 Binuclear center (heme o3/CuB) [ion binding]; other site 932920000077 K-pathway; other site 932920000078 Putative proton exit pathway; other site 932920000079 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 932920000080 Subunit I/III interface [polypeptide binding]; other site 932920000081 Subunit III/IV interface [polypeptide binding]; other site 932920000082 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 932920000083 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 932920000084 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 932920000085 putative active site [active] 932920000086 putative metal binding site [ion binding]; other site 932920000087 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 932920000088 beta-galactosidase; Region: BGL; TIGR03356 932920000089 Bacterial SH3 domain; Region: SH3_3; pfam08239 932920000090 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 932920000091 putative active site [active] 932920000092 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932920000093 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920000094 DNA-binding site [nucleotide binding]; DNA binding site 932920000095 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 932920000096 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 932920000097 active site 932920000098 active pocket/dimerization site; other site 932920000099 phosphorylation site [posttranslational modification] 932920000100 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 932920000101 active site 932920000102 phosphorylation site [posttranslational modification] 932920000103 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 932920000104 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 932920000105 hypothetical protein; Provisional; Region: PRK02947 932920000106 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932920000107 putative active site [active] 932920000108 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 932920000109 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 932920000110 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932920000111 active site turn [active] 932920000112 phosphorylation site [posttranslational modification] 932920000113 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932920000114 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 932920000115 HPr interaction site; other site 932920000116 glycerol kinase (GK) interaction site [polypeptide binding]; other site 932920000117 active site 932920000118 phosphorylation site [posttranslational modification] 932920000119 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 932920000120 putative dimer interface [polypeptide binding]; other site 932920000121 catalytic triad [active] 932920000122 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932920000123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920000124 active site 932920000125 motif I; other site 932920000126 motif II; other site 932920000127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920000128 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932920000129 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932920000130 DNA binding site [nucleotide binding] 932920000131 domain linker motif; other site 932920000132 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 932920000133 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932920000134 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932920000135 nucleotide binding site [chemical binding]; other site 932920000136 Butyrate kinase [Energy production and conversion]; Region: COG3426 932920000137 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 932920000138 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 932920000139 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932920000140 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932920000141 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 932920000142 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 932920000143 dimer interface [polypeptide binding]; other site 932920000144 active site 932920000145 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 932920000146 dimer interface [polypeptide binding]; other site 932920000147 active site 932920000148 putrescine carbamoyltransferase; Provisional; Region: PRK02255 932920000149 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 932920000150 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 932920000151 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 932920000152 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 932920000153 agmatine deiminase; Provisional; Region: PRK13551 932920000154 agmatine deiminase; Region: agmatine_aguA; TIGR03380 932920000155 carbamate kinase; Reviewed; Region: PRK12686 932920000156 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 932920000157 putative substrate binding site [chemical binding]; other site 932920000158 nucleotide binding site [chemical binding]; other site 932920000159 nucleotide binding site [chemical binding]; other site 932920000160 homodimer interface [polypeptide binding]; other site 932920000161 agmatine deiminase; Provisional; Region: PRK13551 932920000162 agmatine deiminase; Region: agmatine_aguA; TIGR03380 932920000163 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932920000164 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932920000165 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932920000166 putative active site [active] 932920000167 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 932920000168 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 932920000169 arginine deiminase; Provisional; Region: PRK01388 932920000170 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 932920000171 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 932920000172 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 932920000173 dimer interface [polypeptide binding]; other site 932920000174 ssDNA binding site [nucleotide binding]; other site 932920000175 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932920000176 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 932920000177 Predicted membrane protein [Function unknown]; Region: COG3212 932920000178 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 932920000179 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 932920000180 putative accessory gene regulator protein; Provisional; Region: PRK01100 932920000181 Staphylococcal AgrD protein; Region: AgrD; cl05477 932920000182 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 932920000183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920000184 ATP binding site [chemical binding]; other site 932920000185 Mg2+ binding site [ion binding]; other site 932920000186 G-X-G motif; other site 932920000187 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 932920000188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920000189 active site 932920000190 phosphorylation site [posttranslational modification] 932920000191 intermolecular recognition site; other site 932920000192 LytTr DNA-binding domain; Region: LytTR; pfam04397 932920000193 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 932920000194 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 932920000195 DHH family; Region: DHH; pfam01368 932920000196 DHHA1 domain; Region: DHHA1; pfam02272 932920000197 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 932920000198 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 932920000199 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 932920000200 replicative DNA helicase; Provisional; Region: PRK05748 932920000201 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 932920000202 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 932920000203 Walker A motif; other site 932920000204 ATP binding site [chemical binding]; other site 932920000205 Walker B motif; other site 932920000206 DNA binding loops [nucleotide binding] 932920000207 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 932920000208 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 932920000209 GDP-binding site [chemical binding]; other site 932920000210 ACT binding site; other site 932920000211 IMP binding site; other site 932920000212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 932920000213 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 932920000214 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 932920000215 Predicted membrane protein [Function unknown]; Region: COG1511 932920000216 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 932920000217 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 932920000218 Uncharacterized small protein [Function unknown]; Region: COG5417 932920000219 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 932920000220 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 932920000221 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 932920000222 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 932920000223 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 932920000224 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 932920000225 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 932920000226 Uncharacterized conserved protein [Function unknown]; Region: COG5444 932920000227 ADP-ribosyltransferase exoenzyme; Region: ADPrib_exo_Tox; pfam03496 932920000228 active site 932920000229 conformational flexibility of ligand binding pocket; other site 932920000230 ADP-ribosylating toxin turn-turn motif; other site 932920000231 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 932920000232 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 932920000233 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 932920000234 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 932920000235 tetramer interface [polypeptide binding]; other site 932920000236 active site 932920000237 Mg2+/Mn2+ binding site [ion binding]; other site 932920000238 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 932920000239 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 932920000240 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 932920000241 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 932920000242 DNA binding site [nucleotide binding] 932920000243 active site 932920000244 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 932920000245 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 932920000246 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 932920000247 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 932920000248 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 932920000249 putative ligand binding site [chemical binding]; other site 932920000250 putative NAD binding site [chemical binding]; other site 932920000251 catalytic site [active] 932920000252 LXG domain of WXG superfamily; Region: LXG; pfam04740 932920000253 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 932920000254 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 932920000255 DNA binding residues [nucleotide binding] 932920000256 putative dimer interface [polypeptide binding]; other site 932920000257 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932920000258 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932920000259 active site 932920000260 catalytic tetrad [active] 932920000261 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920000262 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 932920000263 ATP synthase subunit C; Region: ATP-synt_C; cl00466 932920000264 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 932920000265 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 932920000266 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 932920000267 Walker A motif; other site 932920000268 ATP binding site [chemical binding]; other site 932920000269 Walker B motif; other site 932920000270 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 932920000271 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 932920000272 core domain interface [polypeptide binding]; other site 932920000273 delta subunit interface [polypeptide binding]; other site 932920000274 epsilon subunit interface [polypeptide binding]; other site 932920000275 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 932920000276 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 932920000277 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 932920000278 alpha subunit interaction interface [polypeptide binding]; other site 932920000279 Walker A motif; other site 932920000280 ATP binding site [chemical binding]; other site 932920000281 Walker B motif; other site 932920000282 inhibitor binding site; inhibition site 932920000283 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 932920000284 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823 932920000285 gamma subunit interface [polypeptide binding]; other site 932920000286 epsilon subunit interface [polypeptide binding]; other site 932920000287 LBP interface [polypeptide binding]; other site 932920000288 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920000289 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 932920000290 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 932920000291 active pocket/dimerization site; other site 932920000292 active site 932920000293 phosphorylation site [posttranslational modification] 932920000294 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 932920000295 active site 932920000296 phosphorylation site [posttranslational modification] 932920000297 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 932920000298 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 932920000299 Domain of unknown function (DUF956); Region: DUF956; pfam06115 932920000300 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 932920000301 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932920000302 dimerization interface [polypeptide binding]; other site 932920000303 putative DNA binding site [nucleotide binding]; other site 932920000304 Uncharacterized conserved protein [Function unknown]; Region: COG1359 932920000305 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 932920000306 dimer interface [polypeptide binding]; other site 932920000307 FMN binding site [chemical binding]; other site 932920000308 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 932920000309 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 932920000310 active site 932920000311 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 932920000312 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 932920000313 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 932920000314 aromatic chitin/cellulose binding site residues [chemical binding]; other site 932920000315 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932920000316 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932920000317 nucleotide binding site [chemical binding]; other site 932920000318 butyrate kinase; Region: butyr_kinase; TIGR02707 932920000319 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932920000320 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932920000321 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 932920000322 Walker A/P-loop; other site 932920000323 ATP binding site [chemical binding]; other site 932920000324 Q-loop/lid; other site 932920000325 ABC transporter signature motif; other site 932920000326 Walker B; other site 932920000327 D-loop; other site 932920000328 H-loop/switch region; other site 932920000329 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932920000330 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932920000331 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 932920000332 Walker A/P-loop; other site 932920000333 ATP binding site [chemical binding]; other site 932920000334 Q-loop/lid; other site 932920000335 ABC transporter signature motif; other site 932920000336 Walker B; other site 932920000337 D-loop; other site 932920000338 H-loop/switch region; other site 932920000339 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 932920000340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932920000341 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932920000342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932920000343 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 932920000344 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 932920000345 substrate binding pocket [chemical binding]; other site 932920000346 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932920000347 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920000348 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 932920000349 ligand binding site [chemical binding]; other site 932920000350 flexible hinge region; other site 932920000351 Domain of unknown function (DUF955); Region: DUF955; pfam06114 932920000352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920000353 non-specific DNA binding site [nucleotide binding]; other site 932920000354 salt bridge; other site 932920000355 sequence-specific DNA binding site [nucleotide binding]; other site 932920000356 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 932920000357 Predicted secreted protein [Function unknown]; Region: COG5437 932920000358 Phage-related protein [Function unknown]; Region: COG5412 932920000359 Phage tail protein; Region: Sipho_tail; pfam05709 932920000360 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 932920000361 Predicted membrane protein [Function unknown]; Region: COG1511 932920000362 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 932920000363 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 932920000364 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 932920000365 active site 932920000366 metal binding site [ion binding]; metal-binding site 932920000367 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 932920000368 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 932920000369 putative active site [active] 932920000370 putative metal binding site [ion binding]; other site 932920000371 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 932920000372 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932920000373 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 932920000374 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 932920000375 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 932920000376 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 932920000377 active site 932920000378 Uncharacterized conserved protein [Function unknown]; Region: COG3592 932920000379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920000380 Coenzyme A binding pocket [chemical binding]; other site 932920000381 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 932920000382 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 932920000383 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 932920000384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920000385 dimer interface [polypeptide binding]; other site 932920000386 conserved gate region; other site 932920000387 putative PBP binding loops; other site 932920000388 ABC-ATPase subunit interface; other site 932920000389 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 932920000390 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 932920000391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920000392 dimer interface [polypeptide binding]; other site 932920000393 conserved gate region; other site 932920000394 putative PBP binding loops; other site 932920000395 ABC-ATPase subunit interface; other site 932920000396 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 932920000397 LXG domain of WXG superfamily; Region: LXG; pfam04740 932920000398 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 932920000399 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 932920000400 peptide binding site [polypeptide binding]; other site 932920000401 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 932920000402 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 932920000403 metal binding site [ion binding]; metal-binding site 932920000404 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 932920000405 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 932920000406 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 932920000407 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932920000408 ABC-ATPase subunit interface; other site 932920000409 dimer interface [polypeptide binding]; other site 932920000410 putative PBP binding regions; other site 932920000411 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920000412 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932920000413 ligand binding site [chemical binding]; other site 932920000414 flexible hinge region; other site 932920000415 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 932920000416 DEAD_2; Region: DEAD_2; pfam06733 932920000417 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 932920000418 sugar phosphate phosphatase; Provisional; Region: PRK10513 932920000419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920000420 active site 932920000421 motif I; other site 932920000422 motif II; other site 932920000423 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920000424 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 932920000425 Collagen binding domain; Region: Collagen_bind; pfam05737 932920000426 Cna protein B-type domain; Region: Cna_B; pfam05738 932920000427 Cna protein B-type domain; Region: Cna_B; pfam05738 932920000428 Cna protein B-type domain; Region: Cna_B; pfam05738 932920000429 Cna protein B-type domain; Region: Cna_B; pfam05738 932920000430 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 932920000431 Collagen binding domain; Region: Collagen_bind; pfam05737 932920000432 Cna protein B-type domain; Region: Cna_B; pfam05738 932920000433 Cna protein B-type domain; Region: Cna_B; pfam05738 932920000434 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 932920000435 DNA polymerase III subunit delta'; Validated; Region: PRK08058 932920000436 DNA polymerase III subunit delta'; Validated; Region: PRK08485 932920000437 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 932920000438 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 932920000439 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 932920000440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920000441 S-adenosylmethionine binding site [chemical binding]; other site 932920000442 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 932920000443 GIY-YIG motif/motif A; other site 932920000444 putative active site [active] 932920000445 putative metal binding site [ion binding]; other site 932920000446 Predicted methyltransferases [General function prediction only]; Region: COG0313 932920000447 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 932920000448 putative SAM binding site [chemical binding]; other site 932920000449 putative homodimer interface [polypeptide binding]; other site 932920000450 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 932920000451 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 932920000452 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 932920000453 Uncharacterized conserved protein [Function unknown]; Region: COG5361 932920000454 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 932920000455 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 932920000456 Leucine rich repeat; Region: LRR_8; pfam13855 932920000457 LRR adjacent; Region: LRR_adjacent; pfam08191 932920000458 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920000459 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932920000460 Integrase core domain; Region: rve; pfam00665 932920000461 Integrase core domain; Region: rve_3; cl15866 932920000462 Homeodomain-like domain; Region: HTH_23; pfam13384 932920000463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 932920000464 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932920000465 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920000466 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 932920000467 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 932920000468 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 932920000469 active site 932920000470 HIGH motif; other site 932920000471 KMSKS motif; other site 932920000472 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 932920000473 tRNA binding surface [nucleotide binding]; other site 932920000474 anticodon binding site; other site 932920000475 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 932920000476 dimer interface [polypeptide binding]; other site 932920000477 putative tRNA-binding site [nucleotide binding]; other site 932920000478 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 932920000479 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932920000480 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932920000481 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 932920000482 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 932920000483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920000484 dimer interface [polypeptide binding]; other site 932920000485 conserved gate region; other site 932920000486 putative PBP binding loops; other site 932920000487 ABC-ATPase subunit interface; other site 932920000488 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932920000489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920000490 dimer interface [polypeptide binding]; other site 932920000491 conserved gate region; other site 932920000492 putative PBP binding loops; other site 932920000493 ABC-ATPase subunit interface; other site 932920000494 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 932920000495 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932920000496 alpha-glucosidase; Provisional; Region: PRK10426 932920000497 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 932920000498 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 932920000499 active site 932920000500 catalytic site [active] 932920000501 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 932920000502 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 932920000503 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 932920000504 trimer interface [polypeptide binding]; other site 932920000505 active site 932920000506 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 932920000507 catalytic site [active] 932920000508 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 932920000509 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 932920000510 Ca binding site [ion binding]; other site 932920000511 active site 932920000512 catalytic site [active] 932920000513 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 932920000514 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 932920000515 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 932920000516 active site 932920000517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 932920000518 Domain of unknown function (DUF348); Region: DUF348; pfam03990 932920000519 Domain of unknown function (DUF348); Region: DUF348; pfam03990 932920000520 G5 domain; Region: G5; pfam07501 932920000521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 932920000522 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 932920000523 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 932920000524 putative active site [active] 932920000525 putative metal binding site [ion binding]; other site 932920000526 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 932920000527 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 932920000528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920000529 S-adenosylmethionine binding site [chemical binding]; other site 932920000530 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 932920000531 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 932920000532 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 932920000533 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 932920000534 putative active site [active] 932920000535 YdjC motif; other site 932920000536 Mg binding site [ion binding]; other site 932920000537 putative homodimer interface [polypeptide binding]; other site 932920000538 pur operon repressor; Provisional; Region: PRK09213 932920000539 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 932920000540 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932920000541 active site 932920000542 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 932920000543 HlyD family secretion protein; Region: HlyD_3; pfam13437 932920000544 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932920000545 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932920000546 Walker A/P-loop; other site 932920000547 ATP binding site [chemical binding]; other site 932920000548 Q-loop/lid; other site 932920000549 ABC transporter signature motif; other site 932920000550 Walker B; other site 932920000551 D-loop; other site 932920000552 H-loop/switch region; other site 932920000553 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932920000554 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 932920000555 FtsX-like permease family; Region: FtsX; pfam02687 932920000556 regulatory protein SpoVG; Reviewed; Region: PRK13259 932920000557 regulatory protein SpoVG; Reviewed; Region: PRK13259 932920000558 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 932920000559 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 932920000560 Substrate binding site; other site 932920000561 Mg++ binding site; other site 932920000562 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 932920000563 active site 932920000564 substrate binding site [chemical binding]; other site 932920000565 CoA binding site [chemical binding]; other site 932920000566 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 932920000567 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 932920000568 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932920000569 active site 932920000570 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920000571 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932920000572 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 932920000573 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 932920000574 active site 932920000575 catalytic site [active] 932920000576 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 932920000577 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 932920000578 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 932920000579 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 932920000580 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 932920000581 active site 932920000582 Zn binding site [ion binding]; other site 932920000583 ActA Protein; Region: ActA; pfam05058 932920000584 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 932920000585 Zn binding site [ion binding]; other site 932920000586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 932920000587 hypothetical protein; Provisional; Region: PRK01119 932920000588 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 932920000589 A new structural DNA glycosylase; Region: AlkD_like; cd06561 932920000590 active site 932920000591 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 932920000592 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 932920000593 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932920000594 NAD binding site [chemical binding]; other site 932920000595 dimer interface [polypeptide binding]; other site 932920000596 substrate binding site [chemical binding]; other site 932920000597 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 932920000598 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 932920000599 5S rRNA interface [nucleotide binding]; other site 932920000600 CTC domain interface [polypeptide binding]; other site 932920000601 L16 interface [polypeptide binding]; other site 932920000602 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932920000603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920000604 Coenzyme A binding pocket [chemical binding]; other site 932920000605 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 932920000606 putative active site [active] 932920000607 catalytic residue [active] 932920000608 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 932920000609 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 932920000610 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932920000611 ATP binding site [chemical binding]; other site 932920000612 putative Mg++ binding site [ion binding]; other site 932920000613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932920000614 nucleotide binding region [chemical binding]; other site 932920000615 ATP-binding site [chemical binding]; other site 932920000616 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 932920000617 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 932920000618 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 932920000619 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932920000620 RNA binding surface [nucleotide binding]; other site 932920000621 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 932920000622 Septum formation initiator; Region: DivIC; pfam04977 932920000623 hypothetical protein; Provisional; Region: PRK08582 932920000624 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 932920000625 RNA binding site [nucleotide binding]; other site 932920000626 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 932920000627 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 932920000628 Ligand Binding Site [chemical binding]; other site 932920000629 TilS substrate C-terminal domain; Region: TilS_C; smart00977 932920000630 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 932920000631 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932920000632 active site 932920000633 FtsH Extracellular; Region: FtsH_ext; pfam06480 932920000634 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 932920000635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920000636 Walker A motif; other site 932920000637 ATP binding site [chemical binding]; other site 932920000638 Walker B motif; other site 932920000639 arginine finger; other site 932920000640 Peptidase family M41; Region: Peptidase_M41; pfam01434 932920000641 pantothenate kinase; Reviewed; Region: PRK13318 932920000642 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 932920000643 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 932920000644 dimerization interface [polypeptide binding]; other site 932920000645 domain crossover interface; other site 932920000646 redox-dependent activation switch; other site 932920000647 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 932920000648 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 932920000649 dimer interface [polypeptide binding]; other site 932920000650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920000651 catalytic residue [active] 932920000652 dihydropteroate synthase; Region: DHPS; TIGR01496 932920000653 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 932920000654 substrate binding pocket [chemical binding]; other site 932920000655 dimer interface [polypeptide binding]; other site 932920000656 inhibitor binding site; inhibition site 932920000657 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 932920000658 homooctamer interface [polypeptide binding]; other site 932920000659 active site 932920000660 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 932920000661 catalytic center binding site [active] 932920000662 ATP binding site [chemical binding]; other site 932920000663 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 932920000664 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 932920000665 FMN binding site [chemical binding]; other site 932920000666 active site 932920000667 catalytic residues [active] 932920000668 substrate binding site [chemical binding]; other site 932920000669 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 932920000670 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 932920000671 dimer interface [polypeptide binding]; other site 932920000672 putative anticodon binding site; other site 932920000673 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 932920000674 motif 1; other site 932920000675 active site 932920000676 motif 2; other site 932920000677 motif 3; other site 932920000678 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 932920000679 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 932920000680 UvrB/uvrC motif; Region: UVR; pfam02151 932920000681 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 932920000682 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 932920000683 ADP binding site [chemical binding]; other site 932920000684 phosphagen binding site; other site 932920000685 substrate specificity loop; other site 932920000686 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 932920000687 Clp amino terminal domain; Region: Clp_N; pfam02861 932920000688 Clp amino terminal domain; Region: Clp_N; pfam02861 932920000689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920000690 Walker A motif; other site 932920000691 ATP binding site [chemical binding]; other site 932920000692 Walker B motif; other site 932920000693 arginine finger; other site 932920000694 UvrB/uvrC motif; Region: UVR; pfam02151 932920000695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920000696 Walker A motif; other site 932920000697 ATP binding site [chemical binding]; other site 932920000698 Walker B motif; other site 932920000699 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 932920000700 DNA repair protein RadA; Provisional; Region: PRK11823 932920000701 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 932920000702 Walker A motif/ATP binding site; other site 932920000703 ATP binding site [chemical binding]; other site 932920000704 Walker B motif; other site 932920000705 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 932920000706 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 932920000707 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 932920000708 putative active site [active] 932920000709 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 932920000710 substrate binding site; other site 932920000711 dimer interface; other site 932920000712 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 932920000713 homotrimer interaction site [polypeptide binding]; other site 932920000714 zinc binding site [ion binding]; other site 932920000715 CDP-binding sites; other site 932920000716 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 932920000717 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 932920000718 HIGH motif; other site 932920000719 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 932920000720 active site 932920000721 KMSKS motif; other site 932920000722 serine O-acetyltransferase; Region: cysE; TIGR01172 932920000723 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 932920000724 trimer interface [polypeptide binding]; other site 932920000725 active site 932920000726 substrate binding site [chemical binding]; other site 932920000727 CoA binding site [chemical binding]; other site 932920000728 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 932920000729 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 932920000730 active site 932920000731 HIGH motif; other site 932920000732 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 932920000733 KMSKS motif; other site 932920000734 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 932920000735 tRNA binding surface [nucleotide binding]; other site 932920000736 anticodon binding site; other site 932920000737 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 932920000738 active site 932920000739 metal binding site [ion binding]; metal-binding site 932920000740 dimerization interface [polypeptide binding]; other site 932920000741 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 932920000742 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 932920000743 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 932920000744 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 932920000745 RNA polymerase factor sigma-70; Validated; Region: PRK08295 932920000746 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932920000747 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 932920000748 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 932920000749 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 932920000750 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 932920000751 putative homodimer interface [polypeptide binding]; other site 932920000752 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 932920000753 heterodimer interface [polypeptide binding]; other site 932920000754 homodimer interface [polypeptide binding]; other site 932920000755 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 932920000756 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 932920000757 23S rRNA interface [nucleotide binding]; other site 932920000758 L7/L12 interface [polypeptide binding]; other site 932920000759 putative thiostrepton binding site; other site 932920000760 L25 interface [polypeptide binding]; other site 932920000761 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 932920000762 mRNA/rRNA interface [nucleotide binding]; other site 932920000763 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 932920000764 23S rRNA interface [nucleotide binding]; other site 932920000765 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 932920000766 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 932920000767 core dimer interface [polypeptide binding]; other site 932920000768 peripheral dimer interface [polypeptide binding]; other site 932920000769 L10 interface [polypeptide binding]; other site 932920000770 L11 interface [polypeptide binding]; other site 932920000771 putative EF-Tu interaction site [polypeptide binding]; other site 932920000772 putative EF-G interaction site [polypeptide binding]; other site 932920000773 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 932920000774 Penicillinase repressor; Region: Pencillinase_R; pfam03965 932920000775 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 932920000776 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 932920000777 Protein of unknown function (DUF1307); Region: DUF1307; pfam06998 932920000778 Methyltransferase domain; Region: Methyltransf_31; pfam13847 932920000779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920000780 S-adenosylmethionine binding site [chemical binding]; other site 932920000781 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 932920000782 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 932920000783 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 932920000784 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 932920000785 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 932920000786 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 932920000787 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 932920000788 RPB10 interaction site [polypeptide binding]; other site 932920000789 RPB1 interaction site [polypeptide binding]; other site 932920000790 RPB11 interaction site [polypeptide binding]; other site 932920000791 RPB3 interaction site [polypeptide binding]; other site 932920000792 RPB12 interaction site [polypeptide binding]; other site 932920000793 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 932920000794 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 932920000795 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 932920000796 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 932920000797 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 932920000798 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 932920000799 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 932920000800 G-loop; other site 932920000801 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 932920000802 DNA binding site [nucleotide binding] 932920000803 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 932920000804 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 932920000805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920000806 active site 932920000807 motif I; other site 932920000808 motif II; other site 932920000809 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932920000810 beta-galactosidase; Region: BGL; TIGR03356 932920000811 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932920000812 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932920000813 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920000814 Substrate binding site [chemical binding]; other site 932920000815 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920000816 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920000817 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920000818 LRR adjacent; Region: LRR_adjacent; pfam08191 932920000819 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932920000820 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932920000821 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932920000822 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932920000823 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932920000824 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920000825 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920000826 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920000827 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920000828 LRR adjacent; Region: LRR_adjacent; pfam08191 932920000829 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932920000830 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932920000831 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932920000832 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920000833 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920000834 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920000835 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920000836 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920000837 LRR adjacent; Region: LRR_adjacent; pfam08191 932920000838 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932920000839 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932920000840 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 932920000841 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 932920000842 metal binding site [ion binding]; metal-binding site 932920000843 dimer interface [polypeptide binding]; other site 932920000844 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932920000845 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932920000846 putative Zn2+ binding site [ion binding]; other site 932920000847 putative DNA binding site [nucleotide binding]; other site 932920000848 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 932920000849 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932920000850 Zn binding site [ion binding]; other site 932920000851 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 932920000852 Zn binding site [ion binding]; other site 932920000853 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932920000854 catalytic core [active] 932920000855 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 932920000856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920000857 dimer interface [polypeptide binding]; other site 932920000858 conserved gate region; other site 932920000859 putative PBP binding loops; other site 932920000860 ABC-ATPase subunit interface; other site 932920000861 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 932920000862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920000863 dimer interface [polypeptide binding]; other site 932920000864 conserved gate region; other site 932920000865 ABC-ATPase subunit interface; other site 932920000866 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 932920000867 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932920000868 beta-galactosidase; Region: BGL; TIGR03356 932920000869 sugar phosphate phosphatase; Provisional; Region: PRK10513 932920000870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920000871 active site 932920000872 motif I; other site 932920000873 motif II; other site 932920000874 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920000875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920000876 Coenzyme A binding pocket [chemical binding]; other site 932920000877 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920000878 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932920000879 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 932920000880 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 932920000881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920000882 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 932920000883 active site 932920000884 motif I; other site 932920000885 motif II; other site 932920000886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920000887 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932920000888 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932920000889 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932920000890 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 932920000891 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 932920000892 Walker A/P-loop; other site 932920000893 ATP binding site [chemical binding]; other site 932920000894 Q-loop/lid; other site 932920000895 ABC transporter signature motif; other site 932920000896 Walker B; other site 932920000897 D-loop; other site 932920000898 H-loop/switch region; other site 932920000899 TOBE domain; Region: TOBE; pfam03459 932920000900 ATP cone domain; Region: ATP-cone; pfam03477 932920000901 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 932920000902 Class III ribonucleotide reductase; Region: RNR_III; cd01675 932920000903 effector binding site; other site 932920000904 active site 932920000905 Zn binding site [ion binding]; other site 932920000906 glycine loop; other site 932920000907 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 932920000908 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 932920000909 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920000910 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932920000911 ligand binding site [chemical binding]; other site 932920000912 flexible hinge region; other site 932920000913 Predicted amidohydrolase [General function prediction only]; Region: COG0388 932920000914 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 932920000915 putative active site [active] 932920000916 catalytic triad [active] 932920000917 putative dimer interface [polypeptide binding]; other site 932920000918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920000919 dimer interface [polypeptide binding]; other site 932920000920 conserved gate region; other site 932920000921 ABC-ATPase subunit interface; other site 932920000922 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 932920000923 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 932920000924 Walker A/P-loop; other site 932920000925 ATP binding site [chemical binding]; other site 932920000926 Q-loop/lid; other site 932920000927 ABC transporter signature motif; other site 932920000928 Walker B; other site 932920000929 D-loop; other site 932920000930 H-loop/switch region; other site 932920000931 NIL domain; Region: NIL; pfam09383 932920000932 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 932920000933 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 932920000934 transaminase; Reviewed; Region: PRK08068 932920000935 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932920000936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920000937 homodimer interface [polypeptide binding]; other site 932920000938 catalytic residue [active] 932920000939 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932920000940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920000941 active site 932920000942 phosphorylation site [posttranslational modification] 932920000943 intermolecular recognition site; other site 932920000944 dimerization interface [polypeptide binding]; other site 932920000945 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932920000946 DNA binding site [nucleotide binding] 932920000947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 932920000948 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932920000949 dimerization interface [polypeptide binding]; other site 932920000950 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932920000951 putative active site [active] 932920000952 heme pocket [chemical binding]; other site 932920000953 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932920000954 dimer interface [polypeptide binding]; other site 932920000955 phosphorylation site [posttranslational modification] 932920000956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920000957 ATP binding site [chemical binding]; other site 932920000958 Mg2+ binding site [ion binding]; other site 932920000959 G-X-G motif; other site 932920000960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 932920000961 YycH protein; Region: YycH; pfam07435 932920000962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 932920000963 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 932920000964 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 932920000965 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 932920000966 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 932920000967 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 932920000968 protein binding site [polypeptide binding]; other site 932920000969 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 932920000970 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932920000971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932920000972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 932920000973 dimerization interface [polypeptide binding]; other site 932920000974 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 932920000975 dimer interface [polypeptide binding]; other site 932920000976 FMN binding site [chemical binding]; other site 932920000977 NADPH bind site [chemical binding]; other site 932920000978 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932920000979 HTH domain; Region: HTH_11; pfam08279 932920000980 Mga helix-turn-helix domain; Region: Mga; pfam05043 932920000981 PRD domain; Region: PRD; pfam00874 932920000982 PRD domain; Region: PRD; pfam00874 932920000983 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932920000984 active site 932920000985 P-loop; other site 932920000986 phosphorylation site [posttranslational modification] 932920000987 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920000988 active site 932920000989 phosphorylation site [posttranslational modification] 932920000990 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932920000991 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932920000992 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932920000993 active site 932920000994 P-loop; other site 932920000995 phosphorylation site [posttranslational modification] 932920000996 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932920000997 beta-galactosidase; Region: BGL; TIGR03356 932920000998 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932920000999 methionine cluster; other site 932920001000 active site 932920001001 phosphorylation site [posttranslational modification] 932920001002 metal binding site [ion binding]; metal-binding site 932920001003 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 932920001004 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 932920001005 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 932920001006 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 932920001007 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932920001008 catalytic residue [active] 932920001009 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 932920001010 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 932920001011 nucleophilic elbow; other site 932920001012 catalytic triad; other site 932920001013 Uncharacterized conserved protein [Function unknown]; Region: COG1479 932920001014 Protein of unknown function DUF262; Region: DUF262; pfam03235 932920001015 Protein of unknown function DUF262; Region: DUF262; pfam03235 932920001016 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 932920001017 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 932920001018 Ligand Binding Site [chemical binding]; other site 932920001019 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 932920001020 active site 932920001021 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 932920001022 putative active site [active] 932920001023 YdjC motif; other site 932920001024 Mg binding site [ion binding]; other site 932920001025 putative homodimer interface [polypeptide binding]; other site 932920001026 Putative transcription activator [Transcription]; Region: TenA; COG0819 932920001027 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 932920001028 substrate binding site [chemical binding]; other site 932920001029 multimerization interface [polypeptide binding]; other site 932920001030 ATP binding site [chemical binding]; other site 932920001031 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 932920001032 dimer interface [polypeptide binding]; other site 932920001033 substrate binding site [chemical binding]; other site 932920001034 ATP binding site [chemical binding]; other site 932920001035 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 932920001036 thiamine phosphate binding site [chemical binding]; other site 932920001037 active site 932920001038 pyrophosphate binding site [ion binding]; other site 932920001039 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932920001040 beta-galactosidase; Region: BGL; TIGR03356 932920001041 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932920001042 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 932920001043 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 932920001044 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 932920001045 putative catalytic site [active] 932920001046 putative metal binding site [ion binding]; other site 932920001047 putative phosphate binding site [ion binding]; other site 932920001048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920001049 non-specific DNA binding site [nucleotide binding]; other site 932920001050 salt bridge; other site 932920001051 sequence-specific DNA binding site [nucleotide binding]; other site 932920001052 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 932920001053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920001054 non-specific DNA binding site [nucleotide binding]; other site 932920001055 salt bridge; other site 932920001056 sequence-specific DNA binding site [nucleotide binding]; other site 932920001057 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 932920001058 Leucine rich repeat; Region: LRR_8; pfam13855 932920001059 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001060 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001061 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001062 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001063 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001064 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001065 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001066 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001067 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001068 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001069 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001070 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001071 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001072 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001073 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001074 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 932920001075 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932920001076 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932920001077 Leucine-rich repeats; other site 932920001078 Substrate binding site [chemical binding]; other site 932920001079 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001080 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001081 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001082 Leucine rich repeat; Region: LRR_8; pfam13855 932920001083 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932920001084 Leucine-rich repeats; other site 932920001085 Substrate binding site [chemical binding]; other site 932920001086 Leucine rich repeat; Region: LRR_8; pfam13855 932920001087 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001088 Leucine rich repeat; Region: LRR_8; pfam13855 932920001089 Leucine rich repeat; Region: LRR_8; pfam13855 932920001090 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001091 LRR adjacent; Region: LRR_adjacent; pfam08191 932920001092 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001093 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001094 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001095 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 932920001096 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 932920001097 LXG domain of WXG superfamily; Region: LXG; pfam04740 932920001098 Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221 932920001099 Enterocin A Immunity; Region: EntA_Immun; pfam08951 932920001100 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 932920001101 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 932920001102 TPP-binding site [chemical binding]; other site 932920001103 dimer interface [polypeptide binding]; other site 932920001104 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 932920001105 PYR/PP interface [polypeptide binding]; other site 932920001106 dimer interface [polypeptide binding]; other site 932920001107 TPP binding site [chemical binding]; other site 932920001108 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932920001109 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 932920001110 active site 932920001111 intersubunit interactions; other site 932920001112 catalytic residue [active] 932920001113 short chain dehydrogenase; Provisional; Region: PRK06841 932920001114 classical (c) SDRs; Region: SDR_c; cd05233 932920001115 NAD(P) binding site [chemical binding]; other site 932920001116 active site 932920001117 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 932920001118 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 932920001119 substrate binding site [chemical binding]; other site 932920001120 dimer interface [polypeptide binding]; other site 932920001121 catalytic triad [active] 932920001122 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 932920001123 DAK2 domain; Region: Dak2; cl03685 932920001124 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 932920001125 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 932920001126 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 932920001127 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932920001128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932920001129 putative DNA binding site [nucleotide binding]; other site 932920001130 putative Zn2+ binding site [ion binding]; other site 932920001131 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932920001132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920001133 Coenzyme A binding pocket [chemical binding]; other site 932920001134 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 932920001135 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 932920001136 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 932920001137 acyl-activating enzyme (AAE) consensus motif; other site 932920001138 acyl-activating enzyme (AAE) consensus motif; other site 932920001139 active site 932920001140 AMP binding site [chemical binding]; other site 932920001141 CoA binding site [chemical binding]; other site 932920001142 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 932920001143 L-aspartate oxidase; Provisional; Region: PRK06175 932920001144 putative oxidoreductase; Provisional; Region: PRK10206 932920001145 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932920001146 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932920001147 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920001148 active site 932920001149 phosphorylation site [posttranslational modification] 932920001150 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 932920001151 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932920001152 active site 932920001153 P-loop; other site 932920001154 phosphorylation site [posttranslational modification] 932920001155 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 932920001156 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 932920001157 intersubunit interface [polypeptide binding]; other site 932920001158 active site 932920001159 zinc binding site [ion binding]; other site 932920001160 Na+ binding site [ion binding]; other site 932920001161 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932920001162 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 932920001163 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932920001164 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 932920001165 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 932920001166 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 932920001167 conserved cys residue [active] 932920001168 Predicted transcriptional regulator [Transcription]; Region: COG2378 932920001169 HTH domain; Region: HTH_11; pfam08279 932920001170 WYL domain; Region: WYL; pfam13280 932920001171 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 932920001172 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 932920001173 Imelysin; Region: Peptidase_M75; pfam09375 932920001174 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 932920001175 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 932920001176 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 932920001177 nudix motif; other site 932920001178 hypothetical protein; Provisional; Region: PRK12378 932920001179 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 932920001180 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 932920001181 PhnA protein; Region: PhnA; pfam03831 932920001182 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932920001183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920001184 DNA-binding site [nucleotide binding]; DNA binding site 932920001185 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 932920001186 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932920001187 beta-galactosidase; Region: BGL; TIGR03356 932920001188 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932920001189 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 932920001190 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932920001191 active site 932920001192 P-loop; other site 932920001193 phosphorylation site [posttranslational modification] 932920001194 Predicted transcriptional regulator [Transcription]; Region: COG2378 932920001195 HTH domain; Region: HTH_11; pfam08279 932920001196 WYL domain; Region: WYL; pfam13280 932920001197 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932920001198 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 932920001199 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932920001200 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 932920001201 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 932920001202 tetrameric interface [polypeptide binding]; other site 932920001203 NAD binding site [chemical binding]; other site 932920001204 catalytic residues [active] 932920001205 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 932920001206 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932920001207 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 932920001208 substrate binding site [chemical binding]; other site 932920001209 ATP binding site [chemical binding]; other site 932920001210 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 932920001211 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 932920001212 PYR/PP interface [polypeptide binding]; other site 932920001213 dimer interface [polypeptide binding]; other site 932920001214 TPP binding site [chemical binding]; other site 932920001215 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 932920001216 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 932920001217 TPP-binding site; other site 932920001218 Uncharacterized conserved protein [Function unknown]; Region: COG5646 932920001219 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 932920001220 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 932920001221 ligand binding site [chemical binding]; other site 932920001222 active site 932920001223 UGI interface [polypeptide binding]; other site 932920001224 catalytic site [active] 932920001225 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 932920001226 hypothetical protein; Provisional; Region: PRK13665 932920001227 Bacterial SH3 domain; Region: SH3_3; cl17532 932920001228 NlpC/P60 family; Region: NLPC_P60; pfam00877 932920001229 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932920001230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920001231 Coenzyme A binding pocket [chemical binding]; other site 932920001232 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 932920001233 pyrroline-5-carboxylate reductase; Region: PLN02688 932920001234 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 932920001235 putative hydrophobic ligand binding site [chemical binding]; other site 932920001236 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920001237 active site 932920001238 phosphorylation site [posttranslational modification] 932920001239 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932920001240 active site 932920001241 P-loop; other site 932920001242 phosphorylation site [posttranslational modification] 932920001243 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 932920001244 alpha-mannosidase; Provisional; Region: PRK09819 932920001245 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 932920001246 active site 932920001247 metal binding site [ion binding]; metal-binding site 932920001248 catalytic site [active] 932920001249 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 932920001250 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932920001251 HTH domain; Region: HTH_11; pfam08279 932920001252 Mga helix-turn-helix domain; Region: Mga; pfam05043 932920001253 PRD domain; Region: PRD; pfam00874 932920001254 PRD domain; Region: PRD; pfam00874 932920001255 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932920001256 active site 932920001257 P-loop; other site 932920001258 phosphorylation site [posttranslational modification] 932920001259 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920001260 active site 932920001261 phosphorylation site [posttranslational modification] 932920001262 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 932920001263 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 932920001264 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932920001265 putative metal binding site [ion binding]; other site 932920001266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 932920001267 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 932920001268 trimer interface [polypeptide binding]; other site 932920001269 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932920001270 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 932920001271 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932920001272 Leucine-rich repeats; other site 932920001273 Substrate binding site [chemical binding]; other site 932920001274 LRR adjacent; Region: LRR_adjacent; pfam08191 932920001275 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932920001276 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932920001277 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932920001278 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932920001279 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932920001280 phosphoenolpyruvate synthase; Validated; Region: PRK06241 932920001281 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 932920001282 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 932920001283 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 932920001284 ZIP Zinc transporter; Region: Zip; pfam02535 932920001285 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 932920001286 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 932920001287 NodB motif; other site 932920001288 active site 932920001289 catalytic site [active] 932920001290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920001291 non-specific DNA binding site [nucleotide binding]; other site 932920001292 salt bridge; other site 932920001293 sequence-specific DNA binding site [nucleotide binding]; other site 932920001294 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 932920001295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920001296 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 932920001297 active site 932920001298 motif I; other site 932920001299 motif II; other site 932920001300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920001301 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 932920001302 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 932920001303 Predicted transcriptional regulators [Transcription]; Region: COG1695 932920001304 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 932920001305 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932920001306 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 932920001307 DNA binding residues [nucleotide binding] 932920001308 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 932920001309 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932920001310 HTH domain; Region: HTH_11; pfam08279 932920001311 PRD domain; Region: PRD; pfam00874 932920001312 PRD domain; Region: PRD; pfam00874 932920001313 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932920001314 active site 932920001315 P-loop; other site 932920001316 phosphorylation site [posttranslational modification] 932920001317 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920001318 active site 932920001319 phosphorylation site [posttranslational modification] 932920001320 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920001321 active site 932920001322 phosphorylation site [posttranslational modification] 932920001323 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932920001324 active site 932920001325 P-loop; other site 932920001326 phosphorylation site [posttranslational modification] 932920001327 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 932920001328 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 932920001329 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 932920001330 active site 932920001331 metal binding site [ion binding]; metal-binding site 932920001332 catalytic site [active] 932920001333 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 932920001334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932920001335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932920001336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 932920001337 dimerization interface [polypeptide binding]; other site 932920001338 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 932920001339 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 932920001340 active site 932920001341 substrate binding site [chemical binding]; other site 932920001342 trimer interface [polypeptide binding]; other site 932920001343 CoA binding site [chemical binding]; other site 932920001344 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 932920001345 classical (c) SDRs; Region: SDR_c; cd05233 932920001346 NAD(P) binding site [chemical binding]; other site 932920001347 active site 932920001348 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932920001349 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001350 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932920001351 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001352 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001353 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001354 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001355 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001356 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001357 LRR adjacent; Region: LRR_adjacent; pfam08191 932920001358 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932920001359 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932920001360 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932920001361 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932920001362 Leucine rich repeat; Region: LRR_8; pfam13855 932920001363 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932920001364 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001365 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001366 LRR adjacent; Region: LRR_adjacent; pfam08191 932920001367 Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543 932920001368 SH3-like domain; Region: SH3_8; pfam13457 932920001369 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932920001370 Predicted transcriptional regulator [Transcription]; Region: COG1959 932920001371 Transcriptional regulator; Region: Rrf2; pfam02082 932920001372 Transcriptional regulator; Region: Rrf2; cl17282 932920001373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932920001374 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 932920001375 NAD(P) binding site [chemical binding]; other site 932920001376 active site 932920001377 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 932920001378 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 932920001379 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 932920001380 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 932920001381 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 932920001382 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 932920001383 Transcriptional regulator [Transcription]; Region: LytR; COG1316 932920001384 Predicted membrane protein [Function unknown]; Region: COG1511 932920001385 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 932920001386 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 932920001387 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 932920001388 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 932920001389 Mga helix-turn-helix domain; Region: Mga; pfam05043 932920001390 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 932920001391 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 932920001392 active site 932920001393 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 932920001394 L-tyrosine decarboxylase; Provisional; Region: PRK13520 932920001395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920001396 catalytic residue [active] 932920001397 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 932920001398 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 932920001399 Predicted membrane protein [Function unknown]; Region: COG3619 932920001400 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 932920001401 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 932920001402 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 932920001403 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 932920001404 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 932920001405 Protein of unknown function DUF58; Region: DUF58; pfam01882 932920001406 MoxR-like ATPases [General function prediction only]; Region: COG0714 932920001407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920001408 Walker A motif; other site 932920001409 ATP binding site [chemical binding]; other site 932920001410 Walker B motif; other site 932920001411 arginine finger; other site 932920001412 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 932920001413 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 932920001414 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 932920001415 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 932920001416 Na binding site [ion binding]; other site 932920001417 Uncharacterized conserved protein [Function unknown]; Region: COG3535 932920001418 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 932920001419 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932920001420 nucleotide binding site [chemical binding]; other site 932920001421 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 932920001422 Mga helix-turn-helix domain; Region: Mga; pfam05043 932920001423 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 932920001424 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932920001425 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932920001426 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 932920001427 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932920001428 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932920001429 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932920001430 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932920001431 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932920001432 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932920001433 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932920001434 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 932920001435 DNA methylase; Region: N6_N4_Mtase; pfam01555 932920001436 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 932920001437 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 932920001438 LXG domain of WXG superfamily; Region: LXG; pfam04740 932920001439 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932920001440 Zn2+ binding site [ion binding]; other site 932920001441 Mg2+ binding site [ion binding]; other site 932920001442 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 932920001443 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 932920001444 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 932920001445 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 932920001446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932920001447 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 932920001448 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 932920001449 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932920001450 FeS/SAM binding site; other site 932920001451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 932920001452 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 932920001453 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 932920001454 putative FMN binding site [chemical binding]; other site 932920001455 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 932920001456 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 932920001457 nudix motif; other site 932920001458 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932920001459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932920001460 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 932920001461 putative dimerization interface [polypeptide binding]; other site 932920001462 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 932920001463 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 932920001464 active site 932920001465 FMN binding site [chemical binding]; other site 932920001466 substrate binding site [chemical binding]; other site 932920001467 putative catalytic residue [active] 932920001468 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 932920001469 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932920001470 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932920001471 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 932920001472 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 932920001473 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 932920001474 shikimate binding site; other site 932920001475 NAD(P) binding site [chemical binding]; other site 932920001476 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 932920001477 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 932920001478 active site 932920001479 catalytic residue [active] 932920001480 dimer interface [polypeptide binding]; other site 932920001481 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932920001482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932920001483 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 932920001484 dimerization interface [polypeptide binding]; other site 932920001485 substrate binding pocket [chemical binding]; other site 932920001486 Predicted acyl esterases [General function prediction only]; Region: COG2936 932920001487 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 932920001488 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 932920001489 active site 932920001490 catalytic triad [active] 932920001491 oxyanion hole [active] 932920001492 EamA-like transporter family; Region: EamA; pfam00892 932920001493 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 932920001494 EamA-like transporter family; Region: EamA; pfam00892 932920001495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 932920001496 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932920001497 active site 932920001498 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 932920001499 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 932920001500 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 932920001501 substrate binding site [chemical binding]; other site 932920001502 hexamer interface [polypeptide binding]; other site 932920001503 metal binding site [ion binding]; metal-binding site 932920001504 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 932920001505 catalytic residue [active] 932920001506 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932920001507 PRD domain; Region: PRD; pfam00874 932920001508 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932920001509 active site 932920001510 P-loop; other site 932920001511 phosphorylation site [posttranslational modification] 932920001512 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920001513 active site 932920001514 phosphorylation site [posttranslational modification] 932920001515 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 932920001516 putative active site [active] 932920001517 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920001518 active site 932920001519 phosphorylation site [posttranslational modification] 932920001520 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 932920001521 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 932920001522 substrate binding site [chemical binding]; other site 932920001523 hexamer interface [polypeptide binding]; other site 932920001524 metal binding site [ion binding]; metal-binding site 932920001525 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 932920001526 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 932920001527 putative NAD(P) binding site [chemical binding]; other site 932920001528 catalytic Zn binding site [ion binding]; other site 932920001529 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 932920001530 active site 932920001531 P-loop; other site 932920001532 phosphorylation site [posttranslational modification] 932920001533 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 932920001534 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 932920001535 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 932920001536 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 932920001537 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932920001538 active site 932920001539 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 932920001540 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 932920001541 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 932920001542 catalytic triad [active] 932920001543 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 932920001544 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932920001545 MarR family; Region: MarR_2; pfam12802 932920001546 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001547 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932920001548 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 932920001549 Ligand Binding Site [chemical binding]; other site 932920001550 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 932920001551 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 932920001552 putative active site [active] 932920001553 putative metal binding site [ion binding]; other site 932920001554 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932920001555 catalytic core [active] 932920001556 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932920001557 Predicted membrane protein [Function unknown]; Region: COG3759 932920001558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920001559 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920001560 putative substrate translocation pore; other site 932920001561 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 932920001562 non-specific DNA interactions [nucleotide binding]; other site 932920001563 DNA binding site [nucleotide binding] 932920001564 sequence specific DNA binding site [nucleotide binding]; other site 932920001565 putative cAMP binding site [chemical binding]; other site 932920001566 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932920001567 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 932920001568 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 932920001569 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 932920001570 NAD binding site [chemical binding]; other site 932920001571 sugar binding site [chemical binding]; other site 932920001572 divalent metal binding site [ion binding]; other site 932920001573 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932920001574 dimer interface [polypeptide binding]; other site 932920001575 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932920001576 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932920001577 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932920001578 putative active site [active] 932920001579 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 932920001580 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 932920001581 Sulfate transporter family; Region: Sulfate_transp; pfam00916 932920001582 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 932920001583 Uncharacterized conserved protein [Function unknown]; Region: COG5361 932920001584 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 932920001585 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 932920001586 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 932920001587 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 932920001588 DNA binding residues [nucleotide binding] 932920001589 dimer interface [polypeptide binding]; other site 932920001590 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 932920001591 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 932920001592 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 932920001593 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 932920001594 DXD motif; other site 932920001595 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 932920001596 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932920001597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920001598 S-adenosylmethionine binding site [chemical binding]; other site 932920001599 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 932920001600 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 932920001601 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932920001602 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932920001603 DNA binding site [nucleotide binding] 932920001604 domain linker motif; other site 932920001605 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 932920001606 putative dimerization interface [polypeptide binding]; other site 932920001607 putative ligand binding site [chemical binding]; other site 932920001608 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 932920001609 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 932920001610 NAD binding site [chemical binding]; other site 932920001611 sugar binding site [chemical binding]; other site 932920001612 divalent metal binding site [ion binding]; other site 932920001613 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932920001614 dimer interface [polypeptide binding]; other site 932920001615 allantoate amidohydrolase; Reviewed; Region: PRK09290 932920001616 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 932920001617 active site 932920001618 metal binding site [ion binding]; metal-binding site 932920001619 dimer interface [polypeptide binding]; other site 932920001620 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 932920001621 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 932920001622 metal binding site [ion binding]; metal-binding site 932920001623 putative dimer interface [polypeptide binding]; other site 932920001624 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 932920001625 Beta-lactamase; Region: Beta-lactamase; pfam00144 932920001626 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 932920001627 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 932920001628 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 932920001629 intersubunit interface [polypeptide binding]; other site 932920001630 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 932920001631 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 932920001632 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 932920001633 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 932920001634 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 932920001635 Glucitol operon activator protein (GutM); Region: GutM; cl01890 932920001636 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 932920001637 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932920001638 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 932920001639 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 932920001640 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 932920001641 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920001642 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001643 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001644 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001645 WxL domain surface cell wall-binding; Region: WxL; pfam13731 932920001646 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932920001647 WxL domain surface cell wall-binding; Region: WxL; pfam13731 932920001648 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 932920001649 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 932920001650 FOG: CBS domain [General function prediction only]; Region: COG0517 932920001651 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 932920001652 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 932920001653 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 932920001654 dimer interface [polypeptide binding]; other site 932920001655 active site 932920001656 metal binding site [ion binding]; metal-binding site 932920001657 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 932920001658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920001659 putative substrate translocation pore; other site 932920001660 POT family; Region: PTR2; pfam00854 932920001661 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932920001662 catalytic core [active] 932920001663 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932920001664 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932920001665 catalytic core [active] 932920001666 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 932920001667 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 932920001668 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 932920001669 Cl binding site [ion binding]; other site 932920001670 oligomer interface [polypeptide binding]; other site 932920001671 glutamate dehydrogenase; Provisional; Region: PRK09414 932920001672 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 932920001673 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 932920001674 NAD(P) binding site [chemical binding]; other site 932920001675 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 932920001676 metal binding site [ion binding]; metal-binding site 932920001677 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 932920001678 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 932920001679 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 932920001680 substrate binding site [chemical binding]; other site 932920001681 glutamase interaction surface [polypeptide binding]; other site 932920001682 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 932920001683 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 932920001684 catalytic residues [active] 932920001685 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 932920001686 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 932920001687 putative active site [active] 932920001688 oxyanion strand; other site 932920001689 catalytic triad [active] 932920001690 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 932920001691 putative active site pocket [active] 932920001692 4-fold oligomerization interface [polypeptide binding]; other site 932920001693 metal binding residues [ion binding]; metal-binding site 932920001694 3-fold/trimer interface [polypeptide binding]; other site 932920001695 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 932920001696 histidinol dehydrogenase; Region: hisD; TIGR00069 932920001697 NAD binding site [chemical binding]; other site 932920001698 dimerization interface [polypeptide binding]; other site 932920001699 product binding site; other site 932920001700 substrate binding site [chemical binding]; other site 932920001701 zinc binding site [ion binding]; other site 932920001702 catalytic residues [active] 932920001703 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 932920001704 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 932920001705 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 932920001706 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 932920001707 dimer interface [polypeptide binding]; other site 932920001708 motif 1; other site 932920001709 active site 932920001710 motif 2; other site 932920001711 motif 3; other site 932920001712 histidinol-phosphatase; Reviewed; Region: PRK08123 932920001713 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 932920001714 active site 932920001715 dimer interface [polypeptide binding]; other site 932920001716 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 932920001717 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 932920001718 DNA binding site [nucleotide binding] 932920001719 active site 932920001720 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 932920001721 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 932920001722 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932920001723 beta-galactosidase; Region: BGL; TIGR03356 932920001724 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932920001725 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920001726 DNA-binding site [nucleotide binding]; DNA binding site 932920001727 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 932920001728 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001729 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920001730 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 932920001731 Uncharacterized conserved protein [Function unknown]; Region: COG2966 932920001732 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 932920001733 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 932920001734 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 932920001735 Predicted esterase [General function prediction only]; Region: COG0400 932920001736 putative hydrolase; Provisional; Region: PRK11460 932920001737 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 932920001738 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 932920001739 putative RNA binding site [nucleotide binding]; other site 932920001740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920001741 S-adenosylmethionine binding site [chemical binding]; other site 932920001742 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 932920001743 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932920001744 Bacterial SH3 domain; Region: SH3_3; pfam08239 932920001745 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932920001746 NlpC/P60 family; Region: NLPC_P60; pfam00877 932920001747 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 932920001748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 932920001749 ATP binding site [chemical binding]; other site 932920001750 putative Mg++ binding site [ion binding]; other site 932920001751 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 932920001752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 932920001753 nucleotide binding region [chemical binding]; other site 932920001754 ATP-binding site [chemical binding]; other site 932920001755 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 932920001756 Domain of unknown function DUF20; Region: UPF0118; pfam01594 932920001757 WxL domain surface cell wall-binding; Region: WxL; pfam13731 932920001758 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 932920001759 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 932920001760 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 932920001761 DNA photolyase; Region: DNA_photolyase; pfam00875 932920001762 Predicted membrane protein [Function unknown]; Region: COG4852 932920001763 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 932920001764 DAK2 domain; Region: Dak2; pfam02734 932920001765 EDD domain protein, DegV family; Region: DegV; TIGR00762 932920001766 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 932920001767 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 932920001768 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 932920001769 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 932920001770 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 932920001771 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 932920001772 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 932920001773 homodimer interface [polypeptide binding]; other site 932920001774 substrate-cofactor binding pocket; other site 932920001775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920001776 catalytic residue [active] 932920001777 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 932920001778 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920001779 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 932920001780 ligand binding site [chemical binding]; other site 932920001781 flexible hinge region; other site 932920001782 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 932920001783 BioY family; Region: BioY; pfam02632 932920001784 Predicted transcriptional regulators [Transcription]; Region: COG1695 932920001785 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 932920001786 Predicted membrane protein [Function unknown]; Region: COG4709 932920001787 Uncharacterized conserved protein [Function unknown]; Region: COG3595 932920001788 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 932920001789 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 932920001790 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 932920001791 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 932920001792 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 932920001793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920001794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 932920001795 Coenzyme A binding pocket [chemical binding]; other site 932920001796 Tic20-like protein; Region: Tic20; pfam09685 932920001797 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 932920001798 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 932920001799 Transcriptional regulators [Transcription]; Region: MarR; COG1846 932920001800 MarR family; Region: MarR_2; pfam12802 932920001801 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932920001802 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932920001803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920001804 Walker A/P-loop; other site 932920001805 ATP binding site [chemical binding]; other site 932920001806 Q-loop/lid; other site 932920001807 ABC transporter signature motif; other site 932920001808 Walker B; other site 932920001809 D-loop; other site 932920001810 H-loop/switch region; other site 932920001811 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932920001812 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932920001813 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 932920001814 Walker A/P-loop; other site 932920001815 ATP binding site [chemical binding]; other site 932920001816 Q-loop/lid; other site 932920001817 ABC transporter signature motif; other site 932920001818 Walker B; other site 932920001819 D-loop; other site 932920001820 H-loop/switch region; other site 932920001821 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 932920001822 active site residue [active] 932920001823 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001824 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920001825 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 932920001826 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 932920001827 Transcriptional regulators [Transcription]; Region: MarR; COG1846 932920001828 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932920001829 putative DNA binding site [nucleotide binding]; other site 932920001830 putative Zn2+ binding site [ion binding]; other site 932920001831 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 932920001832 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 932920001833 putative NAD(P) binding site [chemical binding]; other site 932920001834 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 932920001835 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932920001836 Coenzyme A binding pocket [chemical binding]; other site 932920001837 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 932920001838 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 932920001839 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 932920001840 putative active site [active] 932920001841 catalytic site [active] 932920001842 putative metal binding site [ion binding]; other site 932920001843 Catalytic domain of Protein Kinases; Region: PKc; cd00180 932920001844 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 932920001845 active site 932920001846 ATP binding site [chemical binding]; other site 932920001847 substrate binding site [chemical binding]; other site 932920001848 activation loop (A-loop); other site 932920001849 Eukaryotic protein of unknown function (DUF872); Region: DUF872; pfam05915 932920001850 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 932920001851 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 932920001852 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 932920001853 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932920001854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920001855 Coenzyme A binding pocket [chemical binding]; other site 932920001856 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 932920001857 active site 932920001858 catalytic triad [active] 932920001859 oxyanion hole [active] 932920001860 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 932920001861 domain interaction interfaces [polypeptide binding]; other site 932920001862 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 932920001863 domain interaction interfaces [polypeptide binding]; other site 932920001864 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 932920001865 domain interaction interfaces [polypeptide binding]; other site 932920001866 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 932920001867 domain interaction interfaces [polypeptide binding]; other site 932920001868 Isochorismatase family; Region: Isochorismatase; pfam00857 932920001869 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 932920001870 catalytic triad [active] 932920001871 conserved cis-peptide bond; other site 932920001872 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932920001873 Mga helix-turn-helix domain; Region: Mga; pfam05043 932920001874 PRD domain; Region: PRD; pfam00874 932920001875 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932920001876 active site 932920001877 P-loop; other site 932920001878 phosphorylation site [posttranslational modification] 932920001879 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 932920001880 active site 932920001881 phosphorylation site [posttranslational modification] 932920001882 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920001883 active site 932920001884 phosphorylation site [posttranslational modification] 932920001885 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 932920001886 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932920001887 active site 932920001888 P-loop; other site 932920001889 phosphorylation site [posttranslational modification] 932920001890 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 932920001891 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 932920001892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920001893 motif II; other site 932920001894 Predicted transcriptional regulator [Transcription]; Region: COG1959 932920001895 Transcriptional regulator; Region: Rrf2; pfam02082 932920001896 Methyltransferase domain; Region: Methyltransf_31; pfam13847 932920001897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920001898 S-adenosylmethionine binding site [chemical binding]; other site 932920001899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 932920001900 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 932920001901 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932920001902 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932920001903 active site 932920001904 catalytic tetrad [active] 932920001905 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 932920001906 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932920001907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920001908 motif II; other site 932920001909 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 932920001910 catalytic residue [active] 932920001911 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 932920001912 Sulfatase; Region: Sulfatase; pfam00884 932920001913 amino acid transporter; Region: 2A0306; TIGR00909 932920001914 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 932920001915 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 932920001916 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 932920001917 putative metal binding site [ion binding]; other site 932920001918 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 932920001919 active site 932920001920 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 932920001921 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 932920001922 Cl binding site [ion binding]; other site 932920001923 oligomer interface [polypeptide binding]; other site 932920001924 Transcriptional regulators [Transcription]; Region: GntR; COG1802 932920001925 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920001926 DNA-binding site [nucleotide binding]; DNA binding site 932920001927 Predicted membrane protein [Function unknown]; Region: COG1511 932920001928 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 932920001929 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 932920001930 linker region; other site 932920001931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920001932 Transcriptional regulators [Transcription]; Region: GntR; COG1802 932920001933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920001934 DNA-binding site [nucleotide binding]; DNA binding site 932920001935 FCD domain; Region: FCD; cl11656 932920001936 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932920001937 Predicted integral membrane protein [Function unknown]; Region: COG5523 932920001938 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 932920001939 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 932920001940 active site 932920001941 metal binding site [ion binding]; metal-binding site 932920001942 Predicted membrane protein [Function unknown]; Region: COG2322 932920001943 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 932920001944 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 932920001945 minor groove reading motif; other site 932920001946 helix-hairpin-helix signature motif; other site 932920001947 substrate binding pocket [chemical binding]; other site 932920001948 active site 932920001949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920001950 non-specific DNA binding site [nucleotide binding]; other site 932920001951 salt bridge; other site 932920001952 sequence-specific DNA binding site [nucleotide binding]; other site 932920001953 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 932920001954 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 932920001955 Helix-turn-helix domain; Region: HTH_28; pfam13518 932920001956 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 932920001957 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 932920001958 dimer interface [polypeptide binding]; other site 932920001959 substrate binding site [chemical binding]; other site 932920001960 ATP binding site [chemical binding]; other site 932920001961 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932920001962 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920001963 active site 932920001964 motif I; other site 932920001965 motif II; other site 932920001966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920001967 maltose O-acetyltransferase; Provisional; Region: PRK10092 932920001968 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 932920001969 active site 932920001970 substrate binding site [chemical binding]; other site 932920001971 trimer interface [polypeptide binding]; other site 932920001972 CoA binding site [chemical binding]; other site 932920001973 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 932920001974 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 932920001975 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 932920001976 Walker A/P-loop; other site 932920001977 ATP binding site [chemical binding]; other site 932920001978 Q-loop/lid; other site 932920001979 ABC transporter signature motif; other site 932920001980 Walker B; other site 932920001981 D-loop; other site 932920001982 H-loop/switch region; other site 932920001983 inner membrane transport permease; Provisional; Region: PRK15066 932920001984 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 932920001985 oxidoreductase; Provisional; Region: PRK07985 932920001986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932920001987 NAD(P) binding site [chemical binding]; other site 932920001988 active site 932920001989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 932920001990 Predicted membrane protein [Function unknown]; Region: COG3152 932920001991 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 932920001992 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 932920001993 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 932920001994 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 932920001995 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 932920001996 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 932920001997 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 932920001998 FHIPEP family; Region: FHIPEP; pfam00771 932920001999 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 932920002000 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 932920002001 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 932920002002 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 932920002003 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 932920002004 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 932920002005 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 932920002006 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 932920002007 flagellar motor protein MotA; Validated; Region: PRK08124 932920002008 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 932920002009 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 932920002010 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 932920002011 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 932920002012 ligand binding site [chemical binding]; other site 932920002013 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 932920002014 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 932920002015 putative metal binding site; other site 932920002016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932920002017 binding surface 932920002018 TPR motif; other site 932920002019 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 932920002020 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 932920002021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920002022 active site 932920002023 phosphorylation site [posttranslational modification] 932920002024 intermolecular recognition site; other site 932920002025 dimerization interface [polypeptide binding]; other site 932920002026 flagellin; Provisional; Region: PRK12805 932920002027 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 932920002028 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 932920002029 Response regulator receiver domain; Region: Response_reg; pfam00072 932920002030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920002031 active site 932920002032 phosphorylation site [posttranslational modification] 932920002033 intermolecular recognition site; other site 932920002034 dimerization interface [polypeptide binding]; other site 932920002035 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 932920002036 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 932920002037 putative binding surface; other site 932920002038 active site 932920002039 P2 response regulator binding domain; Region: P2; pfam07194 932920002040 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 932920002041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920002042 ATP binding site [chemical binding]; other site 932920002043 Mg2+ binding site [ion binding]; other site 932920002044 G-X-G motif; other site 932920002045 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 932920002046 flagellar motor switch protein; Validated; Region: PRK06788 932920002047 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 932920002048 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 932920002049 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 932920002050 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 932920002051 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 932920002052 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 932920002053 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 932920002054 flagellar motor switch protein; Validated; Region: PRK06789 932920002055 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 932920002056 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 932920002057 flagellar motor switch protein; Reviewed; Region: PRK06782 932920002058 CheC-like family; Region: CheC; pfam04509 932920002059 CheC-like family; Region: CheC; pfam04509 932920002060 Chemotaxis phosphatase CheX; Region: CheX; cl15816 932920002061 CheC-like family; Region: CheC; pfam04509 932920002062 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 932920002063 Protein of unknown function (DUF327); Region: DUF327; pfam03885 932920002064 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 932920002065 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 932920002066 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 932920002067 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 932920002068 flagellar capping protein; Validated; Region: fliD; PRK06798 932920002069 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 932920002070 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 932920002071 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 932920002072 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 932920002073 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 932920002074 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 932920002075 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 932920002076 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 932920002077 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 932920002078 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 932920002079 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 932920002080 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 932920002081 FliG C-terminal domain; Region: FliG_C; pfam01706 932920002082 flagellar assembly protein H; Validated; Region: fliH; PRK06800 932920002083 Flagellar assembly protein FliH; Region: FliH; pfam02108 932920002084 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 932920002085 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 932920002086 Walker A motif; other site 932920002087 ATP binding site [chemical binding]; other site 932920002088 Walker B motif; other site 932920002089 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 932920002090 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 932920002091 N-acetyl-D-glucosamine binding site [chemical binding]; other site 932920002092 catalytic residue [active] 932920002093 Predicted transcriptional regulators [Transcription]; Region: COG1695 932920002094 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 932920002095 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 932920002096 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 932920002097 pyruvate oxidase; Provisional; Region: PRK08611 932920002098 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 932920002099 PYR/PP interface [polypeptide binding]; other site 932920002100 dimer interface [polypeptide binding]; other site 932920002101 tetramer interface [polypeptide binding]; other site 932920002102 TPP binding site [chemical binding]; other site 932920002103 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 932920002104 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 932920002105 TPP-binding site [chemical binding]; other site 932920002106 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 932920002107 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 932920002108 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932920002109 dimerization interface [polypeptide binding]; other site 932920002110 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932920002111 dimer interface [polypeptide binding]; other site 932920002112 putative CheW interface [polypeptide binding]; other site 932920002113 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 932920002114 putative active site [active] 932920002115 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 932920002116 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 932920002117 glutaminase active site [active] 932920002118 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 932920002119 dimer interface [polypeptide binding]; other site 932920002120 active site 932920002121 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 932920002122 dimer interface [polypeptide binding]; other site 932920002123 active site 932920002124 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 932920002125 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 932920002126 active site 932920002127 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 932920002128 GIY-YIG motif/motif A; other site 932920002129 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920002130 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920002131 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932920002132 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932920002133 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920002134 non-specific DNA binding site [nucleotide binding]; other site 932920002135 salt bridge; other site 932920002136 sequence-specific DNA binding site [nucleotide binding]; other site 932920002137 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932920002138 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932920002139 DNA binding site [nucleotide binding] 932920002140 domain linker motif; other site 932920002141 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 932920002142 ligand binding site [chemical binding]; other site 932920002143 dimerization interface [polypeptide binding]; other site 932920002144 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 932920002145 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 932920002146 substrate binding site [chemical binding]; other site 932920002147 hexamer interface [polypeptide binding]; other site 932920002148 metal binding site [ion binding]; metal-binding site 932920002149 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 932920002150 BtpA family; Region: BtpA; cl00440 932920002151 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 932920002152 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 932920002153 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932920002154 active site turn [active] 932920002155 phosphorylation site [posttranslational modification] 932920002156 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932920002157 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 932920002158 HPr interaction site; other site 932920002159 glycerol kinase (GK) interaction site [polypeptide binding]; other site 932920002160 active site 932920002161 phosphorylation site [posttranslational modification] 932920002162 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932920002163 beta-galactosidase; Region: BGL; TIGR03356 932920002164 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920002165 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932920002166 ligand binding site [chemical binding]; other site 932920002167 flexible hinge region; other site 932920002168 Predicted transcriptional regulators [Transcription]; Region: COG1725 932920002169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920002170 DNA-binding site [nucleotide binding]; DNA binding site 932920002171 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 932920002172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920002173 Walker A/P-loop; other site 932920002174 ATP binding site [chemical binding]; other site 932920002175 Q-loop/lid; other site 932920002176 ABC transporter signature motif; other site 932920002177 Walker B; other site 932920002178 D-loop; other site 932920002179 H-loop/switch region; other site 932920002180 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932920002181 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932920002182 Walker A/P-loop; other site 932920002183 ATP binding site [chemical binding]; other site 932920002184 Q-loop/lid; other site 932920002185 ABC transporter signature motif; other site 932920002186 Walker B; other site 932920002187 D-loop; other site 932920002188 H-loop/switch region; other site 932920002189 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932920002190 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 932920002191 FtsX-like permease family; Region: FtsX; pfam02687 932920002192 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932920002193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920002194 non-specific DNA binding site [nucleotide binding]; other site 932920002195 salt bridge; other site 932920002196 sequence-specific DNA binding site [nucleotide binding]; other site 932920002197 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 932920002198 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920002199 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 932920002200 ligand binding site [chemical binding]; other site 932920002201 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 932920002202 non-specific DNA interactions [nucleotide binding]; other site 932920002203 DNA binding site [nucleotide binding] 932920002204 sequence specific DNA binding site [nucleotide binding]; other site 932920002205 putative cAMP binding site [chemical binding]; other site 932920002206 SnoaL-like domain; Region: SnoaL_4; pfam13577 932920002207 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 932920002208 active site 932920002209 catalytic triad [active] 932920002210 oxyanion hole [active] 932920002211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920002212 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 932920002213 Walker A/P-loop; other site 932920002214 ATP binding site [chemical binding]; other site 932920002215 Q-loop/lid; other site 932920002216 ABC transporter signature motif; other site 932920002217 Walker B; other site 932920002218 D-loop; other site 932920002219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932920002220 H-loop/switch region; other site 932920002221 active site 932920002222 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 932920002223 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 932920002224 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 932920002225 Zn binding site [ion binding]; other site 932920002226 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 932920002227 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932920002228 Zn binding site [ion binding]; other site 932920002229 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 932920002230 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932920002231 Zn binding site [ion binding]; other site 932920002232 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 932920002233 Zn binding site [ion binding]; other site 932920002234 Predicted esterase [General function prediction only]; Region: COG0400 932920002235 putative hydrolase; Provisional; Region: PRK11460 932920002236 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 932920002237 GTPases [General function prediction only]; Region: HflX; COG2262 932920002238 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 932920002239 HflX GTPase family; Region: HflX; cd01878 932920002240 G1 box; other site 932920002241 GTP/Mg2+ binding site [chemical binding]; other site 932920002242 Switch I region; other site 932920002243 G2 box; other site 932920002244 G3 box; other site 932920002245 Switch II region; other site 932920002246 G4 box; other site 932920002247 G5 box; other site 932920002248 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 932920002249 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 932920002250 putative active site [active] 932920002251 putative metal binding site [ion binding]; other site 932920002252 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 932920002253 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 932920002254 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 932920002255 Uncharacterized conserved protein [Function unknown]; Region: COG3538 932920002256 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 932920002257 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 932920002258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920002259 dimer interface [polypeptide binding]; other site 932920002260 conserved gate region; other site 932920002261 putative PBP binding loops; other site 932920002262 ABC-ATPase subunit interface; other site 932920002263 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932920002264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920002265 dimer interface [polypeptide binding]; other site 932920002266 conserved gate region; other site 932920002267 putative PBP binding loops; other site 932920002268 ABC-ATPase subunit interface; other site 932920002269 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 932920002270 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 932920002271 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 932920002272 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920002273 DNA-binding site [nucleotide binding]; DNA binding site 932920002274 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932920002275 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 932920002276 ligand binding site [chemical binding]; other site 932920002277 dimerization interface [polypeptide binding]; other site 932920002278 Transcriptional regulators [Transcription]; Region: GntR; COG1802 932920002279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920002280 DNA-binding site [nucleotide binding]; DNA binding site 932920002281 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 932920002282 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 932920002283 putative NADP binding site [chemical binding]; other site 932920002284 putative dimer interface [polypeptide binding]; other site 932920002285 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 932920002286 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 932920002287 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932920002288 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932920002289 nucleotide binding site [chemical binding]; other site 932920002290 Predicted membrane protein [Function unknown]; Region: COG4811 932920002291 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 932920002292 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 932920002293 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 932920002294 active site 932920002295 phosphorylation site [posttranslational modification] 932920002296 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 932920002297 active pocket/dimerization site; other site 932920002298 active site 932920002299 phosphorylation site [posttranslational modification] 932920002300 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 932920002301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920002302 Walker A motif; other site 932920002303 ATP binding site [chemical binding]; other site 932920002304 Walker B motif; other site 932920002305 arginine finger; other site 932920002306 Transcriptional antiterminator [Transcription]; Region: COG3933 932920002307 PRD domain; Region: PRD; pfam00874 932920002308 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 932920002309 active pocket/dimerization site; other site 932920002310 active site 932920002311 phosphorylation site [posttranslational modification] 932920002312 PRD domain; Region: PRD; pfam00874 932920002313 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 932920002314 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 932920002315 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 932920002316 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 932920002317 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 932920002318 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 932920002319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 932920002320 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 932920002321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 932920002322 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 932920002323 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 932920002324 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 932920002325 putative deacylase active site [active] 932920002326 Predicted amidohydrolase [General function prediction only]; Region: COG0388 932920002327 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 932920002328 active site 932920002329 catalytic triad [active] 932920002330 dimer interface [polypeptide binding]; other site 932920002331 Protein of unknown function (DUF554); Region: DUF554; pfam04474 932920002332 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 932920002333 NADH(P)-binding; Region: NAD_binding_10; pfam13460 932920002334 NAD binding site [chemical binding]; other site 932920002335 substrate binding site [chemical binding]; other site 932920002336 putative active site [active] 932920002337 Predicted permeases [General function prediction only]; Region: RarD; COG2962 932920002338 EamA-like transporter family; Region: EamA; pfam00892 932920002339 Uncharacterized conserved protein [Function unknown]; Region: COG2353 932920002340 Transcriptional regulators [Transcription]; Region: MarR; COG1846 932920002341 MarR family; Region: MarR_2; pfam12802 932920002342 lysine transporter; Provisional; Region: PRK10836 932920002343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932920002344 PAS domain; Region: PAS_9; pfam13426 932920002345 putative active site [active] 932920002346 heme pocket [chemical binding]; other site 932920002347 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 932920002348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 932920002349 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932920002350 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920002351 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920002352 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920002353 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920002354 LRR adjacent; Region: LRR_adjacent; pfam08191 932920002355 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932920002356 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932920002357 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 932920002358 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 932920002359 synthetase active site [active] 932920002360 NTP binding site [chemical binding]; other site 932920002361 metal binding site [ion binding]; metal-binding site 932920002362 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 932920002363 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 932920002364 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932920002365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920002366 non-specific DNA binding site [nucleotide binding]; other site 932920002367 salt bridge; other site 932920002368 sequence-specific DNA binding site [nucleotide binding]; other site 932920002369 Cupin domain; Region: Cupin_2; pfam07883 932920002370 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 932920002371 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 932920002372 Walker A/P-loop; other site 932920002373 ATP binding site [chemical binding]; other site 932920002374 Q-loop/lid; other site 932920002375 ABC transporter signature motif; other site 932920002376 Walker B; other site 932920002377 D-loop; other site 932920002378 H-loop/switch region; other site 932920002379 TOBE domain; Region: TOBE_2; pfam08402 932920002380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 932920002381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920002382 putative PBP binding loops; other site 932920002383 ABC-ATPase subunit interface; other site 932920002384 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 932920002385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920002386 dimer interface [polypeptide binding]; other site 932920002387 conserved gate region; other site 932920002388 putative PBP binding loops; other site 932920002389 ABC-ATPase subunit interface; other site 932920002390 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 932920002391 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 932920002392 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 932920002393 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 932920002394 active site 932920002395 zinc binding site [ion binding]; other site 932920002396 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 932920002397 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932920002398 Zn2+ binding site [ion binding]; other site 932920002399 Mg2+ binding site [ion binding]; other site 932920002400 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932920002401 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932920002402 nucleotide binding site [chemical binding]; other site 932920002403 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 932920002404 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 932920002405 FMN binding site [chemical binding]; other site 932920002406 substrate binding site [chemical binding]; other site 932920002407 putative catalytic residue [active] 932920002408 Transcriptional regulators [Transcription]; Region: MarR; COG1846 932920002409 MarR family; Region: MarR_2; pfam12802 932920002410 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 932920002411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920002412 Coenzyme A binding pocket [chemical binding]; other site 932920002413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 932920002414 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 932920002415 dimer interface [polypeptide binding]; other site 932920002416 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932920002417 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 932920002418 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 932920002419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932920002420 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 932920002421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920002422 motif II; other site 932920002423 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 932920002424 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932920002425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920002426 Coenzyme A binding pocket [chemical binding]; other site 932920002427 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 932920002428 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 932920002429 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 932920002430 DNA binding residues [nucleotide binding] 932920002431 putative dimer interface [polypeptide binding]; other site 932920002432 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932920002433 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932920002434 active site 932920002435 catalytic tetrad [active] 932920002436 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 932920002437 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 932920002438 homodimer interface [polypeptide binding]; other site 932920002439 catalytic residues [active] 932920002440 NAD binding site [chemical binding]; other site 932920002441 substrate binding pocket [chemical binding]; other site 932920002442 flexible flap; other site 932920002443 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 932920002444 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 932920002445 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 932920002446 PhoU domain; Region: PhoU; pfam01895 932920002447 PhoU domain; Region: PhoU; pfam01895 932920002448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 932920002449 Integrase core domain; Region: rve; pfam00665 932920002450 Integrase core domain; Region: rve_3; cl15866 932920002451 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 932920002452 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 932920002453 dimer interface [polypeptide binding]; other site 932920002454 PYR/PP interface [polypeptide binding]; other site 932920002455 TPP binding site [chemical binding]; other site 932920002456 substrate binding site [chemical binding]; other site 932920002457 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 932920002458 Domain of unknown function; Region: EKR; smart00890 932920002459 4Fe-4S binding domain; Region: Fer4_6; pfam12837 932920002460 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 932920002461 TPP-binding site [chemical binding]; other site 932920002462 dimer interface [polypeptide binding]; other site 932920002463 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 932920002464 Predicted permeases [General function prediction only]; Region: COG0679 932920002465 Helix-turn-helix domain; Region: HTH_28; pfam13518 932920002466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920002467 non-specific DNA binding site [nucleotide binding]; other site 932920002468 salt bridge; other site 932920002469 sequence-specific DNA binding site [nucleotide binding]; other site 932920002470 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 932920002471 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920002472 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920002473 Predicted membrane protein [Function unknown]; Region: COG3223 932920002474 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932920002475 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932920002476 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 932920002477 Walker A/P-loop; other site 932920002478 ATP binding site [chemical binding]; other site 932920002479 Q-loop/lid; other site 932920002480 ABC transporter signature motif; other site 932920002481 Walker B; other site 932920002482 D-loop; other site 932920002483 H-loop/switch region; other site 932920002484 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 932920002485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920002486 putative substrate translocation pore; other site 932920002487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920002488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920002489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920002490 putative substrate translocation pore; other site 932920002491 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932920002492 MarR family; Region: MarR; pfam01047 932920002493 MarR family; Region: MarR_2; cl17246 932920002494 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 932920002495 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 932920002496 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932920002497 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 932920002498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920002499 motif II; other site 932920002500 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 932920002501 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932920002502 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932920002503 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932920002504 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932920002505 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932920002506 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932920002507 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932920002508 Predicted membrane protein [Function unknown]; Region: COG3326 932920002509 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 932920002510 homotrimer interaction site [polypeptide binding]; other site 932920002511 putative active site [active] 932920002512 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 932920002513 substrate binding site [chemical binding]; other site 932920002514 zinc-binding site [ion binding]; other site 932920002515 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 932920002516 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 932920002517 GIY-YIG motif/motif A; other site 932920002518 active site 932920002519 catalytic site [active] 932920002520 putative DNA binding site [nucleotide binding]; other site 932920002521 metal binding site [ion binding]; metal-binding site 932920002522 UvrB/uvrC motif; Region: UVR; pfam02151 932920002523 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932920002524 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932920002525 substrate binding pocket [chemical binding]; other site 932920002526 membrane-bound complex binding site; other site 932920002527 hinge residues; other site 932920002528 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932920002529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920002530 dimer interface [polypeptide binding]; other site 932920002531 conserved gate region; other site 932920002532 putative PBP binding loops; other site 932920002533 ABC-ATPase subunit interface; other site 932920002534 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 932920002535 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 932920002536 Walker A/P-loop; other site 932920002537 ATP binding site [chemical binding]; other site 932920002538 Q-loop/lid; other site 932920002539 ABC transporter signature motif; other site 932920002540 Walker B; other site 932920002541 D-loop; other site 932920002542 H-loop/switch region; other site 932920002543 amidase; Provisional; Region: PRK11910 932920002544 Amidase; Region: Amidase; cl11426 932920002545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932920002546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932920002547 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 932920002548 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 932920002549 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 932920002550 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 932920002551 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 932920002552 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 932920002553 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 932920002554 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932920002555 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 932920002556 Esterase/lipase [General function prediction only]; Region: COG1647 932920002557 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932920002558 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932920002559 DNA binding site [nucleotide binding] 932920002560 domain linker motif; other site 932920002561 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 932920002562 putative dimerization interface [polypeptide binding]; other site 932920002563 putative ligand binding site [chemical binding]; other site 932920002564 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 932920002565 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932920002566 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 932920002567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920002568 dimer interface [polypeptide binding]; other site 932920002569 conserved gate region; other site 932920002570 putative PBP binding loops; other site 932920002571 ABC-ATPase subunit interface; other site 932920002572 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932920002573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920002574 dimer interface [polypeptide binding]; other site 932920002575 conserved gate region; other site 932920002576 ABC-ATPase subunit interface; other site 932920002577 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 932920002578 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 932920002579 Ca binding site [ion binding]; other site 932920002580 active site 932920002581 catalytic site [active] 932920002582 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 932920002583 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 932920002584 active site 932920002585 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 932920002586 active site 932920002587 substrate binding site [chemical binding]; other site 932920002588 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 932920002589 metal binding site [ion binding]; metal-binding site 932920002590 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 932920002591 DEAD-like helicases superfamily; Region: DEXDc; smart00487 932920002592 ATP binding site [chemical binding]; other site 932920002593 Mg++ binding site [ion binding]; other site 932920002594 motif III; other site 932920002595 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932920002596 nucleotide binding region [chemical binding]; other site 932920002597 ATP-binding site [chemical binding]; other site 932920002598 Predicted membrane protein [Function unknown]; Region: COG4708 932920002599 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 932920002600 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 932920002601 Predicted transcriptional regulators [Transcription]; Region: COG1733 932920002602 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 932920002603 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 932920002604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920002605 putative substrate translocation pore; other site 932920002606 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932920002607 PRD domain; Region: PRD; pfam00874 932920002608 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932920002609 active site 932920002610 P-loop; other site 932920002611 phosphorylation site [posttranslational modification] 932920002612 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920002613 active site 932920002614 phosphorylation site [posttranslational modification] 932920002615 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932920002616 methionine cluster; other site 932920002617 active site 932920002618 phosphorylation site [posttranslational modification] 932920002619 metal binding site [ion binding]; metal-binding site 932920002620 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932920002621 active site 932920002622 P-loop; other site 932920002623 phosphorylation site [posttranslational modification] 932920002624 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932920002625 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932920002626 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 932920002627 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 932920002628 active site 932920002629 trimer interface [polypeptide binding]; other site 932920002630 allosteric site; other site 932920002631 active site lid [active] 932920002632 hexamer (dimer of trimers) interface [polypeptide binding]; other site 932920002633 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932920002634 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932920002635 active site 932920002636 catalytic tetrad [active] 932920002637 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 932920002638 Collagen binding domain; Region: Collagen_bind; pfam05737 932920002639 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 932920002640 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932920002641 Uncharacterized conserved protein [Function unknown]; Region: COG3402 932920002642 Predicted membrane protein [Function unknown]; Region: COG3428 932920002643 Bacterial PH domain; Region: DUF304; pfam03703 932920002644 Bacterial PH domain; Region: DUF304; pfam03703 932920002645 Bacterial PH domain; Region: DUF304; pfam03703 932920002646 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 932920002647 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 932920002648 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 932920002649 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 932920002650 active site 932920002651 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 932920002652 dimer interface [polypeptide binding]; other site 932920002653 substrate binding site [chemical binding]; other site 932920002654 catalytic residues [active] 932920002655 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 932920002656 PemK-like protein; Region: PemK; pfam02452 932920002657 Rsbr N terminal; Region: Rsbr_N; pfam08678 932920002658 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 932920002659 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 932920002660 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 932920002661 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 932920002662 ATP binding site [chemical binding]; other site 932920002663 Mg2+ binding site [ion binding]; other site 932920002664 G-X-G motif; other site 932920002665 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 932920002666 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 932920002667 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 932920002668 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 932920002669 anti sigma factor interaction site; other site 932920002670 regulatory phosphorylation site [posttranslational modification]; other site 932920002671 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 932920002672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920002673 ATP binding site [chemical binding]; other site 932920002674 Mg2+ binding site [ion binding]; other site 932920002675 G-X-G motif; other site 932920002676 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 932920002677 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932920002678 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 932920002679 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 932920002680 DNA binding residues [nucleotide binding] 932920002681 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 932920002682 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 932920002683 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 932920002684 Sulfate transporter family; Region: Sulfate_transp; pfam00916 932920002685 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 932920002686 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 932920002687 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 932920002688 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 932920002689 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 932920002690 RNA binding site [nucleotide binding]; other site 932920002691 hypothetical protein; Provisional; Region: PRK04351 932920002692 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 932920002693 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 932920002694 Uncharacterized conserved protein [Function unknown]; Region: COG5646 932920002695 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932920002696 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932920002697 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932920002698 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920002699 DNA-binding site [nucleotide binding]; DNA binding site 932920002700 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 932920002701 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 932920002702 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 932920002703 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 932920002704 glutathione reductase; Validated; Region: PRK06116 932920002705 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932920002706 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932920002707 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 932920002708 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932920002709 catalytic core [active] 932920002710 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 932920002711 Domain of unknown function DUF20; Region: UPF0118; pfam01594 932920002712 Predicted transcriptional regulators [Transcription]; Region: COG1725 932920002713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920002714 DNA-binding site [nucleotide binding]; DNA binding site 932920002715 Predicted membrane protein [General function prediction only]; Region: COG4194 932920002716 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 932920002717 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 932920002718 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 932920002719 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 932920002720 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 932920002721 tetramerization interface [polypeptide binding]; other site 932920002722 NAD(P) binding site [chemical binding]; other site 932920002723 catalytic residues [active] 932920002724 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 932920002725 active site 932920002726 P-loop; other site 932920002727 phosphorylation site [posttranslational modification] 932920002728 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932920002729 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932920002730 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932920002731 methionine cluster; other site 932920002732 active site 932920002733 phosphorylation site [posttranslational modification] 932920002734 metal binding site [ion binding]; metal-binding site 932920002735 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932920002736 beta-galactosidase; Region: BGL; TIGR03356 932920002737 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932920002738 Mga helix-turn-helix domain; Region: Mga; pfam05043 932920002739 PRD domain; Region: PRD; pfam00874 932920002740 PRD domain; Region: PRD; pfam00874 932920002741 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 932920002742 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920002743 active site 932920002744 phosphorylation site [posttranslational modification] 932920002745 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932920002746 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 932920002747 ABC transporter; Region: ABC_tran_2; pfam12848 932920002748 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932920002749 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 932920002750 Predicted permeases [General function prediction only]; Region: COG0701 932920002751 Predicted membrane protein [Function unknown]; Region: COG3689 932920002752 pantothenate kinase; Provisional; Region: PRK05439 932920002753 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 932920002754 ATP-binding site [chemical binding]; other site 932920002755 CoA-binding site [chemical binding]; other site 932920002756 Mg2+-binding site [ion binding]; other site 932920002757 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 932920002758 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 932920002759 Walker A/P-loop; other site 932920002760 ATP binding site [chemical binding]; other site 932920002761 Q-loop/lid; other site 932920002762 ABC transporter signature motif; other site 932920002763 Walker B; other site 932920002764 D-loop; other site 932920002765 H-loop/switch region; other site 932920002766 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 932920002767 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 932920002768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932920002769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932920002770 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 932920002771 Domain of unknown function (DUF373); Region: DUF373; cl12079 932920002772 Sulfatase; Region: Sulfatase; pfam00884 932920002773 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 932920002774 active site 932920002775 DNA binding site [nucleotide binding] 932920002776 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 932920002777 active site 932920002778 catalytic site [active] 932920002779 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 932920002780 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 932920002781 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 932920002782 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 932920002783 Uncharacterized conserved protein [Function unknown]; Region: COG0398 932920002784 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 932920002785 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 932920002786 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 932920002787 Ligand binding site; other site 932920002788 Putative Catalytic site; other site 932920002789 DXD motif; other site 932920002790 epoxyqueuosine reductase; Region: TIGR00276 932920002791 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 932920002792 A new structural DNA glycosylase; Region: AlkD_like; cl11434 932920002793 active site 932920002794 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 932920002795 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 932920002796 dimer interface [polypeptide binding]; other site 932920002797 FMN binding site [chemical binding]; other site 932920002798 NADPH bind site [chemical binding]; other site 932920002799 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 932920002800 Low molecular weight phosphatase family; Region: LMWPc; cd00115 932920002801 active site 932920002802 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 932920002803 HSP90 family protein; Provisional; Region: PRK14083 932920002804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920002805 ATP binding site [chemical binding]; other site 932920002806 Mg2+ binding site [ion binding]; other site 932920002807 G-X-G motif; other site 932920002808 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 932920002809 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 932920002810 dimerization interface [polypeptide binding]; other site 932920002811 DPS ferroxidase diiron center [ion binding]; other site 932920002812 ion pore; other site 932920002813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 932920002814 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 932920002815 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932920002816 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 932920002817 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 932920002818 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 932920002819 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 932920002820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920002821 putative substrate translocation pore; other site 932920002822 Transcriptional regulators [Transcription]; Region: FadR; COG2186 932920002823 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920002824 DNA-binding site [nucleotide binding]; DNA binding site 932920002825 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 932920002826 Domain of unknown function DUF20; Region: UPF0118; pfam01594 932920002827 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 932920002828 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 932920002829 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 932920002830 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 932920002831 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 932920002832 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 932920002833 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 932920002834 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 932920002835 active site 932920002836 dimer interface [polypeptide binding]; other site 932920002837 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 932920002838 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 932920002839 active site 932920002840 trimer interface [polypeptide binding]; other site 932920002841 allosteric site; other site 932920002842 active site lid [active] 932920002843 hexamer (dimer of trimers) interface [polypeptide binding]; other site 932920002844 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932920002845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920002846 DNA-binding site [nucleotide binding]; DNA binding site 932920002847 UTRA domain; Region: UTRA; pfam07702 932920002848 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 932920002849 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 932920002850 Mg++ binding site [ion binding]; other site 932920002851 putative catalytic motif [active] 932920002852 substrate binding site [chemical binding]; other site 932920002853 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 932920002854 Peptidase family U32; Region: Peptidase_U32; pfam01136 932920002855 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 932920002856 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 932920002857 Peptidase family U32; Region: Peptidase_U32; pfam01136 932920002858 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 932920002859 heat shock protein HtpX; Provisional; Region: PRK04897 932920002860 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 932920002861 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 932920002862 catalytic residues [active] 932920002863 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 932920002864 putative active site [active] 932920002865 putative metal binding residues [ion binding]; other site 932920002866 signature motif; other site 932920002867 putative triphosphate binding site [ion binding]; other site 932920002868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932920002869 TPR motif; other site 932920002870 binding surface 932920002871 TPR repeat; Region: TPR_11; pfam13414 932920002872 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 932920002873 synthetase active site [active] 932920002874 NTP binding site [chemical binding]; other site 932920002875 metal binding site [ion binding]; metal-binding site 932920002876 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 932920002877 ATP-NAD kinase; Region: NAD_kinase; pfam01513 932920002878 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 932920002879 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 932920002880 active site 932920002881 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 932920002882 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 932920002883 NAD binding site [chemical binding]; other site 932920002884 homotetramer interface [polypeptide binding]; other site 932920002885 homodimer interface [polypeptide binding]; other site 932920002886 substrate binding site [chemical binding]; other site 932920002887 active site 932920002888 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 932920002889 DltD N-terminal region; Region: DltD_N; pfam04915 932920002890 DltD central region; Region: DltD_M; pfam04918 932920002891 DltD C-terminal region; Region: DltD_C; pfam04914 932920002892 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 932920002893 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 932920002894 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 932920002895 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 932920002896 acyl-activating enzyme (AAE) consensus motif; other site 932920002897 AMP binding site [chemical binding]; other site 932920002898 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 932920002899 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 932920002900 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932920002901 active site 932920002902 dimer interface [polypeptide binding]; other site 932920002903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920002904 Coenzyme A binding pocket [chemical binding]; other site 932920002905 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 932920002906 Putative esterase; Region: Esterase; pfam00756 932920002907 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 932920002908 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 932920002909 homodimer interface [polypeptide binding]; other site 932920002910 substrate-cofactor binding pocket; other site 932920002911 catalytic residue [active] 932920002912 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 932920002913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920002914 Walker A/P-loop; other site 932920002915 ATP binding site [chemical binding]; other site 932920002916 Q-loop/lid; other site 932920002917 ABC transporter signature motif; other site 932920002918 Walker B; other site 932920002919 D-loop; other site 932920002920 H-loop/switch region; other site 932920002921 ABC-2 type transporter; Region: ABC2_membrane; cl17235 932920002922 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 932920002923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920002924 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920002925 putative substrate translocation pore; other site 932920002926 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 932920002927 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 932920002928 putative oligomer interface [polypeptide binding]; other site 932920002929 putative active site [active] 932920002930 metal binding site [ion binding]; metal-binding site 932920002931 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 932920002932 catalytic residues [active] 932920002933 dimer interface [polypeptide binding]; other site 932920002934 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 932920002935 LytTr DNA-binding domain; Region: LytTR; pfam04397 932920002936 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 932920002937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920002938 Walker A/P-loop; other site 932920002939 ATP binding site [chemical binding]; other site 932920002940 Q-loop/lid; other site 932920002941 ABC transporter signature motif; other site 932920002942 Walker B; other site 932920002943 D-loop; other site 932920002944 H-loop/switch region; other site 932920002945 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 932920002946 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 932920002947 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 932920002948 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 932920002949 G1 box; other site 932920002950 putative GEF interaction site [polypeptide binding]; other site 932920002951 GTP/Mg2+ binding site [chemical binding]; other site 932920002952 Switch I region; other site 932920002953 G2 box; other site 932920002954 G3 box; other site 932920002955 Switch II region; other site 932920002956 G4 box; other site 932920002957 G5 box; other site 932920002958 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 932920002959 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932920002960 MarR family; Region: MarR_2; cl17246 932920002961 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 932920002962 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 932920002963 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 932920002964 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 932920002965 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 932920002966 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 932920002967 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 932920002968 Acyltransferase family; Region: Acyl_transf_3; pfam01757 932920002969 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 932920002970 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 932920002971 DNA binding site [nucleotide binding] 932920002972 active site 932920002973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920002974 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 932920002975 Walker A motif; other site 932920002976 ATP binding site [chemical binding]; other site 932920002977 Walker B motif; other site 932920002978 arginine finger; other site 932920002979 UvrB/uvrC motif; Region: UVR; pfam02151 932920002980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920002981 Walker A motif; other site 932920002982 ATP binding site [chemical binding]; other site 932920002983 Walker B motif; other site 932920002984 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 932920002985 CAAX protease self-immunity; Region: Abi; pfam02517 932920002986 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 932920002987 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 932920002988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 932920002989 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 932920002990 dimerization domain swap beta strand [polypeptide binding]; other site 932920002991 regulatory protein interface [polypeptide binding]; other site 932920002992 active site 932920002993 regulatory phosphorylation site [posttranslational modification]; other site 932920002994 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 932920002995 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 932920002996 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 932920002997 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 932920002998 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 932920002999 Uncharacterized conserved protein [Function unknown]; Region: COG1434 932920003000 putative active site [active] 932920003001 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 932920003002 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 932920003003 aminotransferase A; Validated; Region: PRK07683 932920003004 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932920003005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920003006 homodimer interface [polypeptide binding]; other site 932920003007 catalytic residue [active] 932920003008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 932920003009 FOG: CBS domain [General function prediction only]; Region: COG0517 932920003010 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 932920003011 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932920003012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932920003013 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 932920003014 dimerization interface [polypeptide binding]; other site 932920003015 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 932920003016 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 932920003017 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 932920003018 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 932920003019 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 932920003020 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 932920003021 metal binding site [ion binding]; metal-binding site 932920003022 putative dimer interface [polypeptide binding]; other site 932920003023 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 932920003024 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 932920003025 Mechanosensitive ion channel; Region: MS_channel; pfam00924 932920003026 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 932920003027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920003028 Walker A/P-loop; other site 932920003029 ATP binding site [chemical binding]; other site 932920003030 Q-loop/lid; other site 932920003031 ABC transporter signature motif; other site 932920003032 Walker B; other site 932920003033 D-loop; other site 932920003034 H-loop/switch region; other site 932920003035 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 932920003036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920003037 dimer interface [polypeptide binding]; other site 932920003038 conserved gate region; other site 932920003039 putative PBP binding loops; other site 932920003040 ABC-ATPase subunit interface; other site 932920003041 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 932920003042 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 932920003043 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 932920003044 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 932920003045 HPr interaction site; other site 932920003046 glycerol kinase (GK) interaction site [polypeptide binding]; other site 932920003047 active site 932920003048 phosphorylation site [posttranslational modification] 932920003049 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 932920003050 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 932920003051 S1 domain; Region: S1_2; pfam13509 932920003052 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 932920003053 RNA binding site [nucleotide binding]; other site 932920003054 Predicted membrane protein [Function unknown]; Region: COG4758 932920003055 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 932920003056 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 932920003057 Histidine kinase; Region: HisKA_3; pfam07730 932920003058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920003059 ATP binding site [chemical binding]; other site 932920003060 Mg2+ binding site [ion binding]; other site 932920003061 G-X-G motif; other site 932920003062 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 932920003063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920003064 active site 932920003065 phosphorylation site [posttranslational modification] 932920003066 intermolecular recognition site; other site 932920003067 dimerization interface [polypeptide binding]; other site 932920003068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 932920003069 DNA binding residues [nucleotide binding] 932920003070 dimerization interface [polypeptide binding]; other site 932920003071 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 932920003072 TrkA-N domain; Region: TrkA_N; pfam02254 932920003073 TrkA-C domain; Region: TrkA_C; pfam02080 932920003074 Predicted membrane protein [Function unknown]; Region: COG1289 932920003075 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 932920003076 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 932920003077 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 932920003078 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 932920003079 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 932920003080 hypothetical protein; Provisional; Region: PRK13667 932920003081 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932920003082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920003083 active site 932920003084 motif I; other site 932920003085 motif II; other site 932920003086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920003087 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932920003088 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932920003089 DNA binding site [nucleotide binding] 932920003090 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 932920003091 ligand binding site [chemical binding]; other site 932920003092 dimerization interface [polypeptide binding]; other site 932920003093 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 932920003094 hexamer (dimer of trimers) interface [polypeptide binding]; other site 932920003095 trimer interface [polypeptide binding]; other site 932920003096 substrate binding site [chemical binding]; other site 932920003097 Mn binding site [ion binding]; other site 932920003098 transketolase; Reviewed; Region: PRK05899 932920003099 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 932920003100 TPP-binding site [chemical binding]; other site 932920003101 dimer interface [polypeptide binding]; other site 932920003102 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 932920003103 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 932920003104 PYR/PP interface [polypeptide binding]; other site 932920003105 dimer interface [polypeptide binding]; other site 932920003106 TPP binding site [chemical binding]; other site 932920003107 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932920003108 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 932920003109 Uncharacterized subgroup; belongs to the glycerol kinases subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK_1; cd10427 932920003110 N- and C-terminal domain interface [polypeptide binding]; other site 932920003111 active site 932920003112 MgATP binding site [chemical binding]; other site 932920003113 catalytic site [active] 932920003114 metal binding site [ion binding]; metal-binding site 932920003115 putative glycerol binding site [chemical binding]; other site 932920003116 putative homotetramer interface [polypeptide binding]; other site 932920003117 putative homodimer interface [polypeptide binding]; other site 932920003118 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 932920003119 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932920003120 active site turn [active] 932920003121 phosphorylation site [posttranslational modification] 932920003122 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932920003123 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 932920003124 HPr interaction site; other site 932920003125 glycerol kinase (GK) interaction site [polypeptide binding]; other site 932920003126 active site 932920003127 phosphorylation site [posttranslational modification] 932920003128 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 932920003129 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 932920003130 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 932920003131 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 932920003132 GTP binding site; other site 932920003133 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 932920003134 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 932920003135 Walker A/P-loop; other site 932920003136 ATP binding site [chemical binding]; other site 932920003137 Q-loop/lid; other site 932920003138 ABC transporter signature motif; other site 932920003139 Walker B; other site 932920003140 D-loop; other site 932920003141 H-loop/switch region; other site 932920003142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920003143 dimer interface [polypeptide binding]; other site 932920003144 conserved gate region; other site 932920003145 putative PBP binding loops; other site 932920003146 ABC-ATPase subunit interface; other site 932920003147 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 932920003148 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 932920003149 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 932920003150 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 932920003151 dimer interface [polypeptide binding]; other site 932920003152 putative functional site; other site 932920003153 putative MPT binding site; other site 932920003154 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 932920003155 Walker A motif; other site 932920003156 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 932920003157 MoaE homodimer interface [polypeptide binding]; other site 932920003158 MoaD interaction [polypeptide binding]; other site 932920003159 active site residues [active] 932920003160 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 932920003161 MoaE interaction surface [polypeptide binding]; other site 932920003162 MoeB interaction surface [polypeptide binding]; other site 932920003163 thiocarboxylated glycine; other site 932920003164 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 932920003165 trimer interface [polypeptide binding]; other site 932920003166 dimer interface [polypeptide binding]; other site 932920003167 putative active site [active] 932920003168 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 932920003169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932920003170 FeS/SAM binding site; other site 932920003171 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 932920003172 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 932920003173 MPT binding site; other site 932920003174 trimer interface [polypeptide binding]; other site 932920003175 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 932920003176 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 932920003177 ATP binding site [chemical binding]; other site 932920003178 substrate interface [chemical binding]; other site 932920003179 Flavin Reductases; Region: FlaRed; cl00801 932920003180 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 932920003181 active site 932920003182 catalytic residues [active] 932920003183 metal binding site [ion binding]; metal-binding site 932920003184 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 932920003185 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 932920003186 TPP-binding site [chemical binding]; other site 932920003187 tetramer interface [polypeptide binding]; other site 932920003188 heterodimer interface [polypeptide binding]; other site 932920003189 phosphorylation loop region [posttranslational modification] 932920003190 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 932920003191 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 932920003192 alpha subunit interface [polypeptide binding]; other site 932920003193 TPP binding site [chemical binding]; other site 932920003194 heterodimer interface [polypeptide binding]; other site 932920003195 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932920003196 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 932920003197 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 932920003198 E3 interaction surface; other site 932920003199 lipoyl attachment site [posttranslational modification]; other site 932920003200 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 932920003201 E3 interaction surface; other site 932920003202 lipoyl attachment site [posttranslational modification]; other site 932920003203 e3 binding domain; Region: E3_binding; pfam02817 932920003204 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 932920003205 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 932920003206 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 932920003207 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932920003208 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 932920003209 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 932920003210 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 932920003211 NAD(P) binding site [chemical binding]; other site 932920003212 LDH/MDH dimer interface [polypeptide binding]; other site 932920003213 substrate binding site [chemical binding]; other site 932920003214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476 932920003215 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 932920003216 Thioredoxin; Region: Thioredoxin_4; pfam13462 932920003217 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932920003218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920003219 active site 932920003220 phosphorylation site [posttranslational modification] 932920003221 intermolecular recognition site; other site 932920003222 dimerization interface [polypeptide binding]; other site 932920003223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932920003224 DNA binding site [nucleotide binding] 932920003225 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 932920003226 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932920003227 dimerization interface [polypeptide binding]; other site 932920003228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932920003229 dimer interface [polypeptide binding]; other site 932920003230 phosphorylation site [posttranslational modification] 932920003231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920003232 ATP binding site [chemical binding]; other site 932920003233 Mg2+ binding site [ion binding]; other site 932920003234 G-X-G motif; other site 932920003235 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932920003236 FtsX-like permease family; Region: FtsX; pfam02687 932920003237 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932920003238 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932920003239 Walker A/P-loop; other site 932920003240 ATP binding site [chemical binding]; other site 932920003241 Q-loop/lid; other site 932920003242 ABC transporter signature motif; other site 932920003243 Walker B; other site 932920003244 D-loop; other site 932920003245 H-loop/switch region; other site 932920003246 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 932920003247 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 932920003248 Cl binding site [ion binding]; other site 932920003249 oligomer interface [polypeptide binding]; other site 932920003250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 932920003251 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 932920003252 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 932920003253 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 932920003254 active site 932920003255 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 932920003256 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 932920003257 G1 box; other site 932920003258 putative GEF interaction site [polypeptide binding]; other site 932920003259 GTP/Mg2+ binding site [chemical binding]; other site 932920003260 Switch I region; other site 932920003261 G2 box; other site 932920003262 G3 box; other site 932920003263 Switch II region; other site 932920003264 G4 box; other site 932920003265 G5 box; other site 932920003266 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 932920003267 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 932920003268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 932920003269 hypothetical protein; Provisional; Region: PRK13666 932920003270 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 932920003271 pyruvate carboxylase; Reviewed; Region: PRK12999 932920003272 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 932920003273 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 932920003274 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 932920003275 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 932920003276 active site 932920003277 catalytic residues [active] 932920003278 metal binding site [ion binding]; metal-binding site 932920003279 homodimer binding site [polypeptide binding]; other site 932920003280 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 932920003281 carboxyltransferase (CT) interaction site; other site 932920003282 biotinylation site [posttranslational modification]; other site 932920003283 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 932920003284 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 932920003285 putative binding site residues; other site 932920003286 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 932920003287 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 932920003288 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 932920003289 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 932920003290 Walker A/P-loop; other site 932920003291 ATP binding site [chemical binding]; other site 932920003292 Q-loop/lid; other site 932920003293 ABC transporter signature motif; other site 932920003294 Walker B; other site 932920003295 D-loop; other site 932920003296 H-loop/switch region; other site 932920003297 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 932920003298 SH3-like domain; Region: SH3_8; pfam13457 932920003299 SH3-like domain; Region: SH3_8; pfam13457 932920003300 SH3-like domain; Region: SH3_8; pfam13457 932920003301 SH3-like domain; Region: SH3_8; pfam13457 932920003302 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 932920003303 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 932920003304 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 932920003305 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 932920003306 active site 932920003307 tetramer interface; other site 932920003308 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 932920003309 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 932920003310 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 932920003311 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932920003312 active site 932920003313 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 932920003314 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 932920003315 substrate binding site; other site 932920003316 tetramer interface; other site 932920003317 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 932920003318 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 932920003319 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 932920003320 NAD binding site [chemical binding]; other site 932920003321 substrate binding site [chemical binding]; other site 932920003322 homodimer interface [polypeptide binding]; other site 932920003323 active site 932920003324 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 932920003325 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 932920003326 NADP binding site [chemical binding]; other site 932920003327 active site 932920003328 putative substrate binding site [chemical binding]; other site 932920003329 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 932920003330 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 932920003331 substrate binding site; other site 932920003332 dimer interface; other site 932920003333 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 932920003334 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 932920003335 putative NAD(P) binding site [chemical binding]; other site 932920003336 putative catalytic Zn binding site [ion binding]; other site 932920003337 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 932920003338 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 932920003339 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 932920003340 active site 932920003341 putative glycosyl transferase; Provisional; Region: PRK10073 932920003342 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932920003343 active site 932920003344 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932920003345 active site 932920003346 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 932920003347 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 932920003348 active site 932920003349 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 932920003350 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 932920003351 homodimer interface [polypeptide binding]; other site 932920003352 NAD binding pocket [chemical binding]; other site 932920003353 ATP binding pocket [chemical binding]; other site 932920003354 Mg binding site [ion binding]; other site 932920003355 active-site loop [active] 932920003356 Uncharacterized conserved protein [Function unknown]; Region: COG1359 932920003357 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 932920003358 active site 932920003359 P-loop; other site 932920003360 phosphorylation site [posttranslational modification] 932920003361 GMP synthase; Reviewed; Region: guaA; PRK00074 932920003362 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 932920003363 AMP/PPi binding site [chemical binding]; other site 932920003364 candidate oxyanion hole; other site 932920003365 catalytic triad [active] 932920003366 potential glutamine specificity residues [chemical binding]; other site 932920003367 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 932920003368 ATP Binding subdomain [chemical binding]; other site 932920003369 Dimerization subdomain; other site 932920003370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932920003371 Helix-turn-helix domain; Region: HTH_18; pfam12833 932920003372 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932920003373 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 932920003374 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932920003375 active site 932920003376 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 932920003377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 932920003378 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 932920003379 MepB protein; Region: MepB; cl01985 932920003380 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 932920003381 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 932920003382 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932920003383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920003384 Coenzyme A binding pocket [chemical binding]; other site 932920003385 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 932920003386 Helix-Turn-Helix DNA binding domain of BmrR-like transcription regulators; Region: HTH_BmrR-like; cd04768 932920003387 DNA binding residues [nucleotide binding] 932920003388 drug binding residues [chemical binding]; other site 932920003389 dimer interface [polypeptide binding]; other site 932920003390 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 932920003391 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932920003392 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 932920003393 Walker A/P-loop; other site 932920003394 ATP binding site [chemical binding]; other site 932920003395 Q-loop/lid; other site 932920003396 ABC transporter signature motif; other site 932920003397 Walker B; other site 932920003398 D-loop; other site 932920003399 H-loop/switch region; other site 932920003400 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932920003401 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932920003402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920003403 Walker A/P-loop; other site 932920003404 ATP binding site [chemical binding]; other site 932920003405 Q-loop/lid; other site 932920003406 ABC transporter signature motif; other site 932920003407 Walker B; other site 932920003408 D-loop; other site 932920003409 H-loop/switch region; other site 932920003410 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 932920003411 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 932920003412 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 932920003413 DNA binding residues [nucleotide binding] 932920003414 putative dimer interface [polypeptide binding]; other site 932920003415 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932920003416 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 932920003417 LRR adjacent; Region: LRR_adjacent; pfam08191 932920003418 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932920003419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 932920003420 Clp protease; Region: CLP_protease; pfam00574 932920003421 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 932920003422 oligomer interface [polypeptide binding]; other site 932920003423 active site residues [active] 932920003424 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 932920003425 dimer interface [polypeptide binding]; other site 932920003426 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932920003427 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 932920003428 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 932920003429 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 932920003430 SLBB domain; Region: SLBB; pfam10531 932920003431 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 932920003432 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 932920003433 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 932920003434 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 932920003435 putative hexamer interface [polypeptide binding]; other site 932920003436 putative hexagonal pore; other site 932920003437 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 932920003438 putative hexamer interface [polypeptide binding]; other site 932920003439 putative hexagonal pore; other site 932920003440 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 932920003441 putative hexamer interface [polypeptide binding]; other site 932920003442 putative hexagonal pore; other site 932920003443 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 932920003444 G1 box; other site 932920003445 GTP/Mg2+ binding site [chemical binding]; other site 932920003446 G2 box; other site 932920003447 Switch I region; other site 932920003448 G3 box; other site 932920003449 Switch II region; other site 932920003450 G4 box; other site 932920003451 G5 box; other site 932920003452 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 932920003453 homotrimer interface [polypeptide binding]; other site 932920003454 Walker A motif; other site 932920003455 GTP binding site [chemical binding]; other site 932920003456 Walker B motif; other site 932920003457 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 932920003458 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932920003459 catalytic core [active] 932920003460 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 932920003461 Sensory domain found in PocR; Region: PocR; pfam10114 932920003462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932920003463 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932920003464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932920003465 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 932920003466 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 932920003467 Hexamer interface [polypeptide binding]; other site 932920003468 Hexagonal pore residue; other site 932920003469 propanediol utilization protein PduB; Provisional; Region: PRK15415 932920003470 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 932920003471 putative hexamer interface [polypeptide binding]; other site 932920003472 putative hexagonal pore; other site 932920003473 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 932920003474 putative hexamer interface [polypeptide binding]; other site 932920003475 putative hexagonal pore; other site 932920003476 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 932920003477 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 932920003478 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 932920003479 alpha-beta subunit interface [polypeptide binding]; other site 932920003480 alpha-gamma subunit interface [polypeptide binding]; other site 932920003481 active site 932920003482 substrate and K+ binding site; other site 932920003483 K+ binding site [ion binding]; other site 932920003484 cobalamin binding site [chemical binding]; other site 932920003485 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 932920003486 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 932920003487 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 932920003488 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 932920003489 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 932920003490 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 932920003491 putative hexamer interface [polypeptide binding]; other site 932920003492 putative hexagonal pore; other site 932920003493 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 932920003494 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 932920003495 Hexamer interface [polypeptide binding]; other site 932920003496 Hexagonal pore residue; other site 932920003497 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 932920003498 Propanediol utilisation protein PduL; Region: PduL; pfam06130 932920003499 Propanediol utilisation protein PduL; Region: PduL; pfam06130 932920003500 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 932920003501 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932920003502 nucleotide binding site [chemical binding]; other site 932920003503 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 932920003504 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 932920003505 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 932920003506 Hexamer/Pentamer interface [polypeptide binding]; other site 932920003507 central pore; other site 932920003508 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 932920003509 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 932920003510 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 932920003511 putative catalytic cysteine [active] 932920003512 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 932920003513 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 932920003514 putative active site [active] 932920003515 metal binding site [ion binding]; metal-binding site 932920003516 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 932920003517 amphipathic channel; other site 932920003518 Asn-Pro-Ala signature motifs; other site 932920003519 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 932920003520 propionate/acetate kinase; Provisional; Region: PRK12379 932920003521 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 932920003522 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932920003523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920003524 homodimer interface [polypeptide binding]; other site 932920003525 catalytic residue [active] 932920003526 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 932920003527 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 932920003528 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 932920003529 putative active site [active] 932920003530 metal binding site [ion binding]; metal-binding site 932920003531 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 932920003532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920003533 active site 932920003534 phosphorylation site [posttranslational modification] 932920003535 intermolecular recognition site; other site 932920003536 dimerization interface [polypeptide binding]; other site 932920003537 ANTAR domain; Region: ANTAR; pfam03861 932920003538 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 932920003539 PAS domain S-box; Region: sensory_box; TIGR00229 932920003540 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 932920003541 Histidine kinase; Region: HisKA_2; pfam07568 932920003542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920003543 ATP binding site [chemical binding]; other site 932920003544 Mg2+ binding site [ion binding]; other site 932920003545 G-X-G motif; other site 932920003546 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 932920003547 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 932920003548 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 932920003549 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 932920003550 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 932920003551 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 932920003552 putative hexamer interface [polypeptide binding]; other site 932920003553 putative hexagonal pore; other site 932920003554 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 932920003555 putative hexamer interface [polypeptide binding]; other site 932920003556 putative hexagonal pore; other site 932920003557 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 932920003558 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 932920003559 Hexamer interface [polypeptide binding]; other site 932920003560 Hexagonal pore residue; other site 932920003561 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 932920003562 putative catalytic cysteine [active] 932920003563 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 932920003564 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 932920003565 Hexamer interface [polypeptide binding]; other site 932920003566 Putative hexagonal pore residue; other site 932920003567 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 932920003568 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 932920003569 Propanediol utilisation protein PduL; Region: PduL; pfam06130 932920003570 Propanediol utilisation protein PduL; Region: PduL; pfam06130 932920003571 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 932920003572 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 932920003573 Hexamer/Pentamer interface [polypeptide binding]; other site 932920003574 central pore; other site 932920003575 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 932920003576 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 932920003577 putative hexamer interface [polypeptide binding]; other site 932920003578 putative hexagonal pore; other site 932920003579 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 932920003580 putative hexamer interface [polypeptide binding]; other site 932920003581 putative hexagonal pore; other site 932920003582 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 932920003583 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 932920003584 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 932920003585 hypothetical protein; Region: PHA01818 932920003586 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932920003587 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932920003588 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932920003589 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 932920003590 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 932920003591 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 932920003592 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 932920003593 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 932920003594 catalytic triad [active] 932920003595 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 932920003596 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 932920003597 Precorrin-8X methylmutase; Region: CbiC; pfam02570 932920003598 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 932920003599 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 932920003600 active site 932920003601 putative homodimer interface [polypeptide binding]; other site 932920003602 SAM binding site [chemical binding]; other site 932920003603 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 932920003604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920003605 S-adenosylmethionine binding site [chemical binding]; other site 932920003606 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 932920003607 active site 932920003608 SAM binding site [chemical binding]; other site 932920003609 homodimer interface [polypeptide binding]; other site 932920003610 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 932920003611 active site 932920003612 SAM binding site [chemical binding]; other site 932920003613 homodimer interface [polypeptide binding]; other site 932920003614 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 932920003615 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 932920003616 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 932920003617 active site 932920003618 SAM binding site [chemical binding]; other site 932920003619 homodimer interface [polypeptide binding]; other site 932920003620 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 932920003621 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 932920003622 active site 932920003623 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 932920003624 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 932920003625 active site 932920003626 C-terminal domain interface [polypeptide binding]; other site 932920003627 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 932920003628 active site 932920003629 N-terminal domain interface [polypeptide binding]; other site 932920003630 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 932920003631 active site 932920003632 SAM binding site [chemical binding]; other site 932920003633 homodimer interface [polypeptide binding]; other site 932920003634 cobalt transport protein CbiM; Validated; Region: PRK08319 932920003635 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 932920003636 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 932920003637 cobalt transport protein CbiQ; Provisional; Region: PRK15485 932920003638 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 932920003639 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 932920003640 Walker A/P-loop; other site 932920003641 ATP binding site [chemical binding]; other site 932920003642 Q-loop/lid; other site 932920003643 ABC transporter signature motif; other site 932920003644 Walker B; other site 932920003645 D-loop; other site 932920003646 H-loop/switch region; other site 932920003647 cobyric acid synthase; Provisional; Region: PRK00784 932920003648 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 932920003649 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 932920003650 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 932920003651 catalytic triad [active] 932920003652 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 932920003653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 932920003654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 932920003655 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 932920003656 AAA domain; Region: AAA_17; pfam13207 932920003657 Predicted transcriptional regulators [Transcription]; Region: COG1695 932920003658 Transcriptional regulator PadR-like family; Region: PadR; cl17335 932920003659 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 932920003660 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 932920003661 SH3-like domain; Region: SH3_8; pfam13457 932920003662 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 932920003663 SH3-like domain; Region: SH3_8; pfam13457 932920003664 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 932920003665 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 932920003666 oligomer interface [polypeptide binding]; other site 932920003667 active site 932920003668 metal binding site [ion binding]; metal-binding site 932920003669 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 932920003670 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 932920003671 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 932920003672 Predicted transcriptional regulators [Transcription]; Region: COG1733 932920003673 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 932920003674 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 932920003675 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 932920003676 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 932920003677 dimer interface [polypeptide binding]; other site 932920003678 motif 1; other site 932920003679 active site 932920003680 motif 2; other site 932920003681 motif 3; other site 932920003682 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 932920003683 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 932920003684 putative tRNA-binding site [nucleotide binding]; other site 932920003685 B3/4 domain; Region: B3_4; pfam03483 932920003686 tRNA synthetase B5 domain; Region: B5; smart00874 932920003687 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 932920003688 dimer interface [polypeptide binding]; other site 932920003689 motif 1; other site 932920003690 motif 3; other site 932920003691 motif 2; other site 932920003692 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 932920003693 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932920003694 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932920003695 Walker A/P-loop; other site 932920003696 ATP binding site [chemical binding]; other site 932920003697 Q-loop/lid; other site 932920003698 ABC transporter signature motif; other site 932920003699 Walker B; other site 932920003700 D-loop; other site 932920003701 H-loop/switch region; other site 932920003702 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932920003703 FtsX-like permease family; Region: FtsX; pfam02687 932920003704 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 932920003705 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932920003706 FtsX-like permease family; Region: FtsX; pfam02687 932920003707 Transcriptional regulators [Transcription]; Region: MarR; COG1846 932920003708 MarR family; Region: MarR_2; pfam12802 932920003709 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 932920003710 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 932920003711 ligand binding site [chemical binding]; other site 932920003712 active site 932920003713 UGI interface [polypeptide binding]; other site 932920003714 catalytic site [active] 932920003715 ribonuclease HIII; Provisional; Region: PRK00996 932920003716 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 932920003717 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 932920003718 RNA/DNA hybrid binding site [nucleotide binding]; other site 932920003719 active site 932920003720 Cell division protein ZapA; Region: ZapA; cl01146 932920003721 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 932920003722 Colicin V production protein; Region: Colicin_V; pfam02674 932920003723 hypothetical protein; Provisional; Region: PRK08609 932920003724 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 932920003725 active site 932920003726 primer binding site [nucleotide binding]; other site 932920003727 NTP binding site [chemical binding]; other site 932920003728 metal binding triad [ion binding]; metal-binding site 932920003729 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 932920003730 active site 932920003731 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 932920003732 MutS domain III; Region: MutS_III; pfam05192 932920003733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920003734 Walker A/P-loop; other site 932920003735 ATP binding site [chemical binding]; other site 932920003736 Q-loop/lid; other site 932920003737 ABC transporter signature motif; other site 932920003738 Walker B; other site 932920003739 D-loop; other site 932920003740 H-loop/switch region; other site 932920003741 Smr domain; Region: Smr; pfam01713 932920003742 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 932920003743 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 932920003744 catalytic residues [active] 932920003745 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 932920003746 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 932920003747 GIY-YIG motif/motif A; other site 932920003748 active site 932920003749 catalytic site [active] 932920003750 putative DNA binding site [nucleotide binding]; other site 932920003751 metal binding site [ion binding]; metal-binding site 932920003752 UvrB/uvrC motif; Region: UVR; pfam02151 932920003753 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 932920003754 aspartate kinase; Reviewed; Region: PRK06635 932920003755 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 932920003756 putative nucleotide binding site [chemical binding]; other site 932920003757 putative catalytic residues [active] 932920003758 putative Mg ion binding site [ion binding]; other site 932920003759 putative aspartate binding site [chemical binding]; other site 932920003760 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 932920003761 putative allosteric regulatory site; other site 932920003762 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 932920003763 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 932920003764 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 932920003765 ribonuclease PH; Reviewed; Region: rph; PRK00173 932920003766 Ribonuclease PH; Region: RNase_PH_bact; cd11362 932920003767 hexamer interface [polypeptide binding]; other site 932920003768 active site 932920003769 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 932920003770 active site 932920003771 dimerization interface [polypeptide binding]; other site 932920003772 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 932920003773 active site 932920003774 metal binding site [ion binding]; metal-binding site 932920003775 homotetramer interface [polypeptide binding]; other site 932920003776 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 932920003777 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 932920003778 Int/Topo IB signature motif; other site 932920003779 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 932920003780 Domain of unknown function (DUF955); Region: DUF955; pfam06114 932920003781 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932920003782 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920003783 non-specific DNA binding site [nucleotide binding]; other site 932920003784 salt bridge; other site 932920003785 sequence-specific DNA binding site [nucleotide binding]; other site 932920003786 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 932920003787 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 932920003788 salt bridge; other site 932920003789 non-specific DNA binding site [nucleotide binding]; other site 932920003790 sequence-specific DNA binding site [nucleotide binding]; other site 932920003791 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 932920003792 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 932920003793 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 932920003794 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 932920003795 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 932920003796 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 932920003797 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 932920003798 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 932920003799 active site 932920003800 metal-binding site 932920003801 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 932920003802 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 932920003803 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 932920003804 Protein of unknown function (DUF722); Region: DUF722; pfam05263 932920003805 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 932920003806 putative active site [active] 932920003807 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 932920003808 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 932920003809 active site 932920003810 Phage terminase, small subunit; Region: Terminase_4; cl01525 932920003811 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 932920003812 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 932920003813 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 932920003814 Phage portal protein; Region: Phage_portal; pfam04860 932920003815 Phage-related protein [Function unknown]; Region: COG4695; cl01923 932920003816 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 932920003817 oligomer interface [polypeptide binding]; other site 932920003818 active site residues [active] 932920003819 Phage capsid family; Region: Phage_capsid; pfam05065 932920003820 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 932920003821 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 932920003822 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 932920003823 N-acetyl-D-glucosamine binding site [chemical binding]; other site 932920003824 catalytic residue [active] 932920003825 Phage tail protein; Region: Sipho_tail; cl17486 932920003826 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 932920003827 Bacteriophage holin; Region: Phage_holin_1; pfam04531 932920003828 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 932920003829 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 932920003830 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 932920003831 Uncharacterized conserved protein [Function unknown]; Region: COG5361 932920003832 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 932920003833 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 932920003834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 932920003835 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 932920003836 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 932920003837 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 932920003838 dimer interface [polypeptide binding]; other site 932920003839 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932920003840 catalytic core [active] 932920003841 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 932920003842 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 932920003843 ATP binding site [chemical binding]; other site 932920003844 Mg++ binding site [ion binding]; other site 932920003845 motif III; other site 932920003846 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932920003847 nucleotide binding region [chemical binding]; other site 932920003848 ATP-binding site [chemical binding]; other site 932920003849 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 932920003850 RNA binding site [nucleotide binding]; other site 932920003851 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 932920003852 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 932920003853 putative active site [active] 932920003854 nucleotide binding site [chemical binding]; other site 932920003855 nudix motif; other site 932920003856 putative metal binding site [ion binding]; other site 932920003857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920003858 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920003859 putative substrate translocation pore; other site 932920003860 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920003861 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932920003862 ligand binding site [chemical binding]; other site 932920003863 flexible hinge region; other site 932920003864 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 932920003865 Uncharacterized conserved protein [Function unknown]; Region: COG1284 932920003866 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 932920003867 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 932920003868 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 932920003869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920003870 DNA-binding site [nucleotide binding]; DNA binding site 932920003871 UTRA domain; Region: UTRA; pfam07702 932920003872 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 932920003873 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 932920003874 Ca binding site [ion binding]; other site 932920003875 active site 932920003876 catalytic site [active] 932920003877 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 932920003878 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932920003879 active site turn [active] 932920003880 phosphorylation site [posttranslational modification] 932920003881 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932920003882 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 932920003883 nudix motif; other site 932920003884 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 932920003885 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 932920003886 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 932920003887 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 932920003888 putative catalytic cysteine [active] 932920003889 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 932920003890 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 932920003891 nucleotide binding site [chemical binding]; other site 932920003892 homotetrameric interface [polypeptide binding]; other site 932920003893 putative phosphate binding site [ion binding]; other site 932920003894 putative allosteric binding site; other site 932920003895 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 932920003896 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 932920003897 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932920003898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920003899 non-specific DNA binding site [nucleotide binding]; other site 932920003900 salt bridge; other site 932920003901 sequence-specific DNA binding site [nucleotide binding]; other site 932920003902 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920003903 non-specific DNA binding site [nucleotide binding]; other site 932920003904 salt bridge; other site 932920003905 sequence-specific DNA binding site [nucleotide binding]; other site 932920003906 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 932920003907 active site 932920003908 trigger factor; Provisional; Region: tig; PRK01490 932920003909 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 932920003910 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 932920003911 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 932920003912 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 932920003913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920003914 Walker A motif; other site 932920003915 ATP binding site [chemical binding]; other site 932920003916 Walker B motif; other site 932920003917 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 932920003918 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 932920003919 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 932920003920 Catalytic site [active] 932920003921 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 932920003922 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 932920003923 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 932920003924 Catalytic site [active] 932920003925 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 932920003926 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 932920003927 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 932920003928 Catalytic site [active] 932920003929 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 932920003930 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 932920003931 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 932920003932 GTP/Mg2+ binding site [chemical binding]; other site 932920003933 G4 box; other site 932920003934 G5 box; other site 932920003935 G1 box; other site 932920003936 Switch I region; other site 932920003937 G2 box; other site 932920003938 G3 box; other site 932920003939 Switch II region; other site 932920003940 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 932920003941 RNA/DNA hybrid binding site [nucleotide binding]; other site 932920003942 active site 932920003943 DNA protecting protein DprA; Region: dprA; TIGR00732 932920003944 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 932920003945 DNA topoisomerase I; Validated; Region: PRK05582 932920003946 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 932920003947 active site 932920003948 interdomain interaction site; other site 932920003949 putative metal-binding site [ion binding]; other site 932920003950 nucleotide binding site [chemical binding]; other site 932920003951 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 932920003952 domain I; other site 932920003953 DNA binding groove [nucleotide binding] 932920003954 phosphate binding site [ion binding]; other site 932920003955 domain II; other site 932920003956 domain III; other site 932920003957 nucleotide binding site [chemical binding]; other site 932920003958 catalytic site [active] 932920003959 domain IV; other site 932920003960 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 932920003961 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 932920003962 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 932920003963 Glucose inhibited division protein A; Region: GIDA; pfam01134 932920003964 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 932920003965 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 932920003966 active site 932920003967 DNA binding site [nucleotide binding] 932920003968 Int/Topo IB signature motif; other site 932920003969 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 932920003970 active site 932920003971 HslU subunit interaction site [polypeptide binding]; other site 932920003972 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 932920003973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920003974 Walker A motif; other site 932920003975 ATP binding site [chemical binding]; other site 932920003976 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 932920003977 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 932920003978 transcriptional repressor CodY; Validated; Region: PRK04158 932920003979 CodY GAF-like domain; Region: CodY; pfam06018 932920003980 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 932920003981 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 932920003982 active site 932920003983 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 932920003984 active site 932920003985 catalytic residues [active] 932920003986 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 932920003987 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 932920003988 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 932920003989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920003990 Mg2+ binding site [ion binding]; other site 932920003991 G-X-G motif; other site 932920003992 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 932920003993 anchoring element; other site 932920003994 dimer interface [polypeptide binding]; other site 932920003995 ATP binding site [chemical binding]; other site 932920003996 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 932920003997 active site 932920003998 putative metal-binding site [ion binding]; other site 932920003999 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 932920004000 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 932920004001 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 932920004002 CAP-like domain; other site 932920004003 active site 932920004004 primary dimer interface [polypeptide binding]; other site 932920004005 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932920004006 S-ribosylhomocysteinase; Provisional; Region: PRK02260 932920004007 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920004008 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920004009 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 932920004010 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 932920004011 catalytic triad [active] 932920004012 catalytic triad [active] 932920004013 oxyanion hole [active] 932920004014 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 932920004015 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 932920004016 active site 932920004017 catalytic site [active] 932920004018 metal binding site [ion binding]; metal-binding site 932920004019 dimer interface [polypeptide binding]; other site 932920004020 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 932920004021 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 932920004022 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 932920004023 bacterial Hfq-like; Region: Hfq; cd01716 932920004024 hexamer interface [polypeptide binding]; other site 932920004025 Sm1 motif; other site 932920004026 RNA binding site [nucleotide binding]; other site 932920004027 Sm2 motif; other site 932920004028 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 932920004029 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 932920004030 HflX GTPase family; Region: HflX; cd01878 932920004031 G1 box; other site 932920004032 GTP/Mg2+ binding site [chemical binding]; other site 932920004033 Switch I region; other site 932920004034 G2 box; other site 932920004035 G3 box; other site 932920004036 Switch II region; other site 932920004037 G4 box; other site 932920004038 G5 box; other site 932920004039 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 932920004040 Aluminium resistance protein; Region: Alum_res; pfam06838 932920004041 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 932920004042 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 932920004043 DNA binding residues [nucleotide binding] 932920004044 putative dimer interface [polypeptide binding]; other site 932920004045 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 932920004046 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 932920004047 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 932920004048 arsenical pump membrane protein; Provisional; Region: PRK15445 932920004049 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 932920004050 transmembrane helices; other site 932920004051 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932920004052 LexA repressor; Validated; Region: PRK00215 932920004053 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932920004054 putative DNA binding site [nucleotide binding]; other site 932920004055 putative Zn2+ binding site [ion binding]; other site 932920004056 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 932920004057 Catalytic site [active] 932920004058 cell division suppressor protein YneA; Provisional; Region: PRK14125 932920004059 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 932920004060 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 932920004061 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 932920004062 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 932920004063 TPP-binding site [chemical binding]; other site 932920004064 dimer interface [polypeptide binding]; other site 932920004065 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 932920004066 PYR/PP interface [polypeptide binding]; other site 932920004067 dimer interface [polypeptide binding]; other site 932920004068 TPP binding site [chemical binding]; other site 932920004069 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932920004070 hypothetical protein; Provisional; Region: PRK01844 932920004071 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 932920004072 Protein of unknown function (DUF970); Region: DUF970; cl17525 932920004073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 932920004074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920004075 S-adenosylmethionine binding site [chemical binding]; other site 932920004076 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 932920004077 ParB-like nuclease domain; Region: ParBc; pfam02195 932920004078 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 932920004079 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 932920004080 Active Sites [active] 932920004081 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 932920004082 DEAD-like helicases superfamily; Region: DEXDc; smart00487 932920004083 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 932920004084 putative nucleotide binding site [chemical binding]; other site 932920004085 uridine monophosphate binding site [chemical binding]; other site 932920004086 homohexameric interface [polypeptide binding]; other site 932920004087 ribosome recycling factor; Reviewed; Region: frr; PRK00083 932920004088 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 932920004089 hinge region; other site 932920004090 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 932920004091 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 932920004092 catalytic residue [active] 932920004093 putative FPP diphosphate binding site; other site 932920004094 putative FPP binding hydrophobic cleft; other site 932920004095 dimer interface [polypeptide binding]; other site 932920004096 putative IPP diphosphate binding site; other site 932920004097 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 932920004098 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 932920004099 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 932920004100 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 932920004101 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 932920004102 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 932920004103 RIP metalloprotease RseP; Region: TIGR00054 932920004104 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 932920004105 active site 932920004106 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 932920004107 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 932920004108 protein binding site [polypeptide binding]; other site 932920004109 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 932920004110 putative substrate binding region [chemical binding]; other site 932920004111 prolyl-tRNA synthetase; Provisional; Region: PRK09194 932920004112 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 932920004113 dimer interface [polypeptide binding]; other site 932920004114 motif 1; other site 932920004115 active site 932920004116 motif 2; other site 932920004117 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 932920004118 putative deacylase active site [active] 932920004119 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 932920004120 active site 932920004121 motif 3; other site 932920004122 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 932920004123 anticodon binding site; other site 932920004124 DNA polymerase III PolC; Validated; Region: polC; PRK00448 932920004125 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 932920004126 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 932920004127 generic binding surface II; other site 932920004128 generic binding surface I; other site 932920004129 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 932920004130 active site 932920004131 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 932920004132 active site 932920004133 catalytic site [active] 932920004134 substrate binding site [chemical binding]; other site 932920004135 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 932920004136 ribosome maturation protein RimP; Reviewed; Region: PRK00092 932920004137 Sm and related proteins; Region: Sm_like; cl00259 932920004138 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 932920004139 putative oligomer interface [polypeptide binding]; other site 932920004140 putative RNA binding site [nucleotide binding]; other site 932920004141 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 932920004142 NusA N-terminal domain; Region: NusA_N; pfam08529 932920004143 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 932920004144 RNA binding site [nucleotide binding]; other site 932920004145 homodimer interface [polypeptide binding]; other site 932920004146 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 932920004147 G-X-X-G motif; other site 932920004148 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 932920004149 G-X-X-G motif; other site 932920004150 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 932920004151 putative RNA binding cleft [nucleotide binding]; other site 932920004152 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 932920004153 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 932920004154 translation initiation factor IF-2; Region: IF-2; TIGR00487 932920004155 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 932920004156 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 932920004157 G1 box; other site 932920004158 putative GEF interaction site [polypeptide binding]; other site 932920004159 GTP/Mg2+ binding site [chemical binding]; other site 932920004160 Switch I region; other site 932920004161 G2 box; other site 932920004162 G3 box; other site 932920004163 Switch II region; other site 932920004164 G4 box; other site 932920004165 G5 box; other site 932920004166 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 932920004167 Translation-initiation factor 2; Region: IF-2; pfam11987 932920004168 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 932920004169 Protein of unknown function (DUF503); Region: DUF503; cl00669 932920004170 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 932920004171 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 932920004172 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 932920004173 RNA binding site [nucleotide binding]; other site 932920004174 active site 932920004175 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 932920004176 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 932920004177 active site 932920004178 Riboflavin kinase; Region: Flavokinase; smart00904 932920004179 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 932920004180 16S/18S rRNA binding site [nucleotide binding]; other site 932920004181 S13e-L30e interaction site [polypeptide binding]; other site 932920004182 25S rRNA binding site [nucleotide binding]; other site 932920004183 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 932920004184 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 932920004185 RNase E interface [polypeptide binding]; other site 932920004186 trimer interface [polypeptide binding]; other site 932920004187 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 932920004188 RNase E interface [polypeptide binding]; other site 932920004189 trimer interface [polypeptide binding]; other site 932920004190 active site 932920004191 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 932920004192 putative nucleic acid binding region [nucleotide binding]; other site 932920004193 G-X-X-G motif; other site 932920004194 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 932920004195 RNA binding site [nucleotide binding]; other site 932920004196 domain interface; other site 932920004197 GTPase RsgA; Reviewed; Region: PRK01889 932920004198 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 932920004199 RNA binding site [nucleotide binding]; other site 932920004200 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 932920004201 GTPase/Zn-binding domain interface [polypeptide binding]; other site 932920004202 GTP/Mg2+ binding site [chemical binding]; other site 932920004203 G4 box; other site 932920004204 G5 box; other site 932920004205 G1 box; other site 932920004206 Switch I region; other site 932920004207 G2 box; other site 932920004208 G3 box; other site 932920004209 Switch II region; other site 932920004210 YceG-like family; Region: YceG; pfam02618 932920004211 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 932920004212 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 932920004213 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 932920004214 Rhomboid family; Region: Rhomboid; pfam01694 932920004215 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932920004216 TPR motif; other site 932920004217 TPR repeat; Region: TPR_11; pfam13414 932920004218 binding surface 932920004219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 932920004220 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 932920004221 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932920004222 nucleotide binding site [chemical binding]; other site 932920004223 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 932920004224 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 932920004225 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 932920004226 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 932920004227 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 932920004228 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 932920004229 Type II/IV secretion system protein; Region: T2SE; pfam00437 932920004230 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 932920004231 Walker A motif; other site 932920004232 ATP binding site [chemical binding]; other site 932920004233 Walker B motif; other site 932920004234 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 932920004235 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 932920004236 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 932920004237 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 932920004238 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 932920004239 tetramer interface [polypeptide binding]; other site 932920004240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920004241 catalytic residue [active] 932920004242 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 932920004243 tetramer interface [polypeptide binding]; other site 932920004244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920004245 catalytic residue [active] 932920004246 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 932920004247 active site residue [active] 932920004248 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 932920004249 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 932920004250 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 932920004251 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 932920004252 active site 932920004253 elongation factor P; Validated; Region: PRK00529 932920004254 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 932920004255 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 932920004256 RNA binding site [nucleotide binding]; other site 932920004257 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 932920004258 RNA binding site [nucleotide binding]; other site 932920004259 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 932920004260 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 932920004261 carboxyltransferase (CT) interaction site; other site 932920004262 biotinylation site [posttranslational modification]; other site 932920004263 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 932920004264 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 932920004265 ATP-grasp domain; Region: ATP-grasp_4; cl17255 932920004266 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 932920004267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 932920004268 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 932920004269 putative RNA binding site [nucleotide binding]; other site 932920004270 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 932920004271 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 932920004272 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 932920004273 homodimer interface [polypeptide binding]; other site 932920004274 NADP binding site [chemical binding]; other site 932920004275 substrate binding site [chemical binding]; other site 932920004276 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 932920004277 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 932920004278 generic binding surface II; other site 932920004279 generic binding surface I; other site 932920004280 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 932920004281 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 932920004282 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 932920004283 substrate binding pocket [chemical binding]; other site 932920004284 chain length determination region; other site 932920004285 substrate-Mg2+ binding site; other site 932920004286 catalytic residues [active] 932920004287 aspartate-rich region 1; other site 932920004288 active site lid residues [active] 932920004289 aspartate-rich region 2; other site 932920004290 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 932920004291 DNA-binding site [nucleotide binding]; DNA binding site 932920004292 RNA-binding motif; other site 932920004293 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 932920004294 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 932920004295 TPP-binding site; other site 932920004296 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 932920004297 PYR/PP interface [polypeptide binding]; other site 932920004298 dimer interface [polypeptide binding]; other site 932920004299 TPP binding site [chemical binding]; other site 932920004300 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932920004301 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 932920004302 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932920004303 RNA binding surface [nucleotide binding]; other site 932920004304 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 932920004305 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 932920004306 arginine repressor; Provisional; Region: PRK04280 932920004307 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 932920004308 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 932920004309 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 932920004310 Walker A/P-loop; other site 932920004311 ATP binding site [chemical binding]; other site 932920004312 Q-loop/lid; other site 932920004313 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 932920004314 ABC transporter signature motif; other site 932920004315 Walker B; other site 932920004316 D-loop; other site 932920004317 H-loop/switch region; other site 932920004318 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 932920004319 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932920004320 nucleotide binding site [chemical binding]; other site 932920004321 Acetokinase family; Region: Acetate_kinase; cl17229 932920004322 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 932920004323 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932920004324 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 932920004325 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 932920004326 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 932920004327 tetramer interface [polypeptide binding]; other site 932920004328 TPP-binding site [chemical binding]; other site 932920004329 heterodimer interface [polypeptide binding]; other site 932920004330 phosphorylation loop region [posttranslational modification] 932920004331 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 932920004332 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 932920004333 alpha subunit interface [polypeptide binding]; other site 932920004334 TPP binding site [chemical binding]; other site 932920004335 heterodimer interface [polypeptide binding]; other site 932920004336 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932920004337 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 932920004338 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 932920004339 E3 interaction surface; other site 932920004340 lipoyl attachment site [posttranslational modification]; other site 932920004341 e3 binding domain; Region: E3_binding; pfam02817 932920004342 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 932920004343 peptidase T-like protein; Region: PepT-like; TIGR01883 932920004344 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 932920004345 metal binding site [ion binding]; metal-binding site 932920004346 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 932920004347 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 932920004348 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 932920004349 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932920004350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920004351 active site 932920004352 phosphorylation site [posttranslational modification] 932920004353 intermolecular recognition site; other site 932920004354 dimerization interface [polypeptide binding]; other site 932920004355 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932920004356 DNA binding site [nucleotide binding] 932920004357 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 932920004358 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932920004359 dimerization interface [polypeptide binding]; other site 932920004360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932920004361 dimer interface [polypeptide binding]; other site 932920004362 phosphorylation site [posttranslational modification] 932920004363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920004364 ATP binding site [chemical binding]; other site 932920004365 Mg2+ binding site [ion binding]; other site 932920004366 G-X-G motif; other site 932920004367 OxaA-like protein precursor; Validated; Region: PRK01622 932920004368 acylphosphatase; Provisional; Region: PRK14443 932920004369 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 932920004370 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 932920004371 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 932920004372 homotetramer interface [polypeptide binding]; other site 932920004373 FMN binding site [chemical binding]; other site 932920004374 homodimer contacts [polypeptide binding]; other site 932920004375 putative active site [active] 932920004376 putative substrate binding site [chemical binding]; other site 932920004377 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 932920004378 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 932920004379 active site residue [active] 932920004380 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 932920004381 Uncharacterized conserved protein [Function unknown]; Region: COG1284 932920004382 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 932920004383 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 932920004384 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 932920004385 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 932920004386 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 932920004387 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 932920004388 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 932920004389 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 932920004390 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 932920004391 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 932920004392 ligand binding site [chemical binding]; other site 932920004393 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 932920004394 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932920004395 Walker A/P-loop; other site 932920004396 ATP binding site [chemical binding]; other site 932920004397 Q-loop/lid; other site 932920004398 ABC transporter signature motif; other site 932920004399 Walker B; other site 932920004400 D-loop; other site 932920004401 H-loop/switch region; other site 932920004402 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 932920004403 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932920004404 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 932920004405 TM-ABC transporter signature motif; other site 932920004406 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932920004407 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 932920004408 TM-ABC transporter signature motif; other site 932920004409 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 932920004410 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 932920004411 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 932920004412 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 932920004413 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 932920004414 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 932920004415 classical (c) SDRs; Region: SDR_c; cd05233 932920004416 NAD(P) binding site [chemical binding]; other site 932920004417 active site 932920004418 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 932920004419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920004420 non-specific DNA binding site [nucleotide binding]; other site 932920004421 salt bridge; other site 932920004422 sequence-specific DNA binding site [nucleotide binding]; other site 932920004423 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 932920004424 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 932920004425 competence damage-inducible protein A; Provisional; Region: PRK00549 932920004426 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 932920004427 putative MPT binding site; other site 932920004428 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 932920004429 recombinase A; Provisional; Region: recA; PRK09354 932920004430 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 932920004431 hexamer interface [polypeptide binding]; other site 932920004432 Walker A motif; other site 932920004433 ATP binding site [chemical binding]; other site 932920004434 Walker B motif; other site 932920004435 phosphodiesterase; Provisional; Region: PRK12704 932920004436 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932920004437 Zn2+ binding site [ion binding]; other site 932920004438 Mg2+ binding site [ion binding]; other site 932920004439 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 932920004440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920004441 Coenzyme A binding pocket [chemical binding]; other site 932920004442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 932920004443 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 932920004444 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 932920004445 putative active site [active] 932920004446 metal binding site [ion binding]; metal-binding site 932920004447 homodimer binding site [polypeptide binding]; other site 932920004448 Predicted membrane protein [Function unknown]; Region: COG4550 932920004449 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 932920004450 MutS domain I; Region: MutS_I; pfam01624 932920004451 MutS domain II; Region: MutS_II; pfam05188 932920004452 MutS domain III; Region: MutS_III; pfam05192 932920004453 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 932920004454 Walker A/P-loop; other site 932920004455 ATP binding site [chemical binding]; other site 932920004456 Q-loop/lid; other site 932920004457 ABC transporter signature motif; other site 932920004458 Walker B; other site 932920004459 D-loop; other site 932920004460 H-loop/switch region; other site 932920004461 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 932920004462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920004463 ATP binding site [chemical binding]; other site 932920004464 Mg2+ binding site [ion binding]; other site 932920004465 G-X-G motif; other site 932920004466 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 932920004467 ATP binding site [chemical binding]; other site 932920004468 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 932920004469 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 932920004470 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 932920004471 Pyruvate formate lyase 1; Region: PFL1; cd01678 932920004472 coenzyme A binding site [chemical binding]; other site 932920004473 active site 932920004474 catalytic residues [active] 932920004475 glycine loop; other site 932920004476 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 932920004477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932920004478 FeS/SAM binding site; other site 932920004479 Predicted transcriptional regulators [Transcription]; Region: COG1695 932920004480 Transcriptional regulator PadR-like family; Region: PadR; cl17335 932920004481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920004482 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920004483 putative substrate translocation pore; other site 932920004484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920004485 non-specific DNA binding site [nucleotide binding]; other site 932920004486 salt bridge; other site 932920004487 sequence-specific DNA binding site [nucleotide binding]; other site 932920004488 topology modulation protein; Provisional; Region: PRK07261 932920004489 AAA domain; Region: AAA_17; pfam13207 932920004490 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920004491 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920004492 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920004493 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932920004494 putative acyltransferase; Provisional; Region: PRK05790 932920004495 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 932920004496 dimer interface [polypeptide binding]; other site 932920004497 active site 932920004498 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 932920004499 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 932920004500 dimer interface [polypeptide binding]; other site 932920004501 active site 932920004502 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 932920004503 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 932920004504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920004505 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 932920004506 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 932920004507 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 932920004508 Domain of unknown function DUF20; Region: UPF0118; pfam01594 932920004509 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 932920004510 FAD binding domain; Region: FAD_binding_4; pfam01565 932920004511 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 932920004512 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 932920004513 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 932920004514 Walker A/P-loop; other site 932920004515 ATP binding site [chemical binding]; other site 932920004516 Q-loop/lid; other site 932920004517 ABC transporter signature motif; other site 932920004518 Walker B; other site 932920004519 D-loop; other site 932920004520 H-loop/switch region; other site 932920004521 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 932920004522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920004523 dimer interface [polypeptide binding]; other site 932920004524 conserved gate region; other site 932920004525 ABC-ATPase subunit interface; other site 932920004526 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 932920004527 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 932920004528 manganese transport protein MntH; Reviewed; Region: PRK00701 932920004529 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 932920004530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920004531 dimer interface [polypeptide binding]; other site 932920004532 conserved gate region; other site 932920004533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 932920004534 ABC-ATPase subunit interface; other site 932920004535 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 932920004536 LysR substrate binding domain; Region: LysR_substrate; pfam03466 932920004537 dimerization interface [polypeptide binding]; other site 932920004538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920004539 dimer interface [polypeptide binding]; other site 932920004540 conserved gate region; other site 932920004541 putative PBP binding loops; other site 932920004542 ABC-ATPase subunit interface; other site 932920004543 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 932920004544 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 932920004545 Walker A/P-loop; other site 932920004546 ATP binding site [chemical binding]; other site 932920004547 Q-loop/lid; other site 932920004548 ABC transporter signature motif; other site 932920004549 Walker B; other site 932920004550 D-loop; other site 932920004551 H-loop/switch region; other site 932920004552 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 932920004553 Predicted membrane protein [Function unknown]; Region: COG3859 932920004554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 932920004555 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 932920004556 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932920004557 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932920004558 ABC transporter; Region: ABC_tran_2; pfam12848 932920004559 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932920004560 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 932920004561 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932920004562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932920004563 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 932920004564 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 932920004565 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932920004566 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 932920004567 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 932920004568 dihydrodipicolinate synthase; Region: dapA; TIGR00674 932920004569 dimer interface [polypeptide binding]; other site 932920004570 active site 932920004571 catalytic residue [active] 932920004572 aspartate kinase I; Reviewed; Region: PRK08210 932920004573 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 932920004574 nucleotide binding site [chemical binding]; other site 932920004575 substrate binding site [chemical binding]; other site 932920004576 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 932920004577 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 932920004578 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 932920004579 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 932920004580 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 932920004581 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 932920004582 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 932920004583 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 932920004584 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 932920004585 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 932920004586 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 932920004587 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 932920004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 932920004589 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 932920004590 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 932920004591 Predicted membrane protein [Function unknown]; Region: COG4392 932920004592 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 932920004593 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 932920004594 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 932920004595 metal binding site 2 [ion binding]; metal-binding site 932920004596 putative DNA binding helix; other site 932920004597 metal binding site 1 [ion binding]; metal-binding site 932920004598 dimer interface [polypeptide binding]; other site 932920004599 structural Zn2+ binding site [ion binding]; other site 932920004600 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 932920004601 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932920004602 ABC-ATPase subunit interface; other site 932920004603 dimer interface [polypeptide binding]; other site 932920004604 putative PBP binding regions; other site 932920004605 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 932920004606 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 932920004607 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 932920004608 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 932920004609 DHHA2 domain; Region: DHHA2; pfam02833 932920004610 endonuclease IV; Provisional; Region: PRK01060 932920004611 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 932920004612 AP (apurinic/apyrimidinic) site pocket; other site 932920004613 DNA interaction; other site 932920004614 Metal-binding active site; metal-binding site 932920004615 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 932920004616 DEAD-like helicases superfamily; Region: DEXDc; smart00487 932920004617 ATP binding site [chemical binding]; other site 932920004618 Mg++ binding site [ion binding]; other site 932920004619 motif III; other site 932920004620 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932920004621 nucleotide binding region [chemical binding]; other site 932920004622 ATP-binding site [chemical binding]; other site 932920004623 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 932920004624 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 932920004625 Uncharacterized conserved protein [Function unknown]; Region: COG0327 932920004626 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 932920004627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 932920004628 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 932920004629 Uncharacterized conserved protein [Function unknown]; Region: COG0327 932920004630 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 932920004631 Family of unknown function (DUF633); Region: DUF633; pfam04816 932920004632 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 932920004633 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 932920004634 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 932920004635 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932920004636 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 932920004637 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 932920004638 DNA binding residues [nucleotide binding] 932920004639 DNA primase; Validated; Region: dnaG; PRK05667 932920004640 CHC2 zinc finger; Region: zf-CHC2; pfam01807 932920004641 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 932920004642 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 932920004643 active site 932920004644 metal binding site [ion binding]; metal-binding site 932920004645 interdomain interaction site; other site 932920004646 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 932920004647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 932920004648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 932920004649 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 932920004650 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 932920004651 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 932920004652 dimer interface [polypeptide binding]; other site 932920004653 motif 1; other site 932920004654 active site 932920004655 motif 2; other site 932920004656 motif 3; other site 932920004657 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 932920004658 Recombination protein O N terminal; Region: RecO_N; pfam11967 932920004659 Recombination protein O C terminal; Region: RecO_C; pfam02565 932920004660 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 932920004661 GTPase Era; Reviewed; Region: era; PRK00089 932920004662 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 932920004663 G1 box; other site 932920004664 GTP/Mg2+ binding site [chemical binding]; other site 932920004665 Switch I region; other site 932920004666 G2 box; other site 932920004667 Switch II region; other site 932920004668 G3 box; other site 932920004669 G4 box; other site 932920004670 G5 box; other site 932920004671 KH domain; Region: KH_2; pfam07650 932920004672 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 932920004673 active site 932920004674 catalytic motif [active] 932920004675 Zn binding site [ion binding]; other site 932920004676 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 932920004677 metal-binding heat shock protein; Provisional; Region: PRK00016 932920004678 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 932920004679 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 932920004680 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932920004681 Zn2+ binding site [ion binding]; other site 932920004682 Mg2+ binding site [ion binding]; other site 932920004683 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 932920004684 PhoH-like protein; Region: PhoH; pfam02562 932920004685 Yqey-like protein; Region: YqeY; pfam09424 932920004686 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 932920004687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 932920004688 RNA methyltransferase, RsmE family; Region: TIGR00046 932920004689 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 932920004690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920004691 S-adenosylmethionine binding site [chemical binding]; other site 932920004692 chaperone protein DnaJ; Provisional; Region: PRK14280 932920004693 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 932920004694 HSP70 interaction site [polypeptide binding]; other site 932920004695 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 932920004696 substrate binding site [polypeptide binding]; other site 932920004697 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 932920004698 Zn binding sites [ion binding]; other site 932920004699 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 932920004700 dimer interface [polypeptide binding]; other site 932920004701 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 932920004702 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 932920004703 nucleotide binding site [chemical binding]; other site 932920004704 NEF interaction site [polypeptide binding]; other site 932920004705 SBD interface [polypeptide binding]; other site 932920004706 heat shock protein GrpE; Provisional; Region: PRK14140 932920004707 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 932920004708 dimer interface [polypeptide binding]; other site 932920004709 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 932920004710 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 932920004711 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 932920004712 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 932920004713 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932920004714 FeS/SAM binding site; other site 932920004715 HemN C-terminal domain; Region: HemN_C; pfam06969 932920004716 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 932920004717 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 932920004718 NADP binding site [chemical binding]; other site 932920004719 putative substrate binding site [chemical binding]; other site 932920004720 active site 932920004721 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 932920004722 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 932920004723 DNA binding residues [nucleotide binding] 932920004724 putative dimer interface [polypeptide binding]; other site 932920004725 GTP-binding protein LepA; Provisional; Region: PRK05433 932920004726 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 932920004727 G1 box; other site 932920004728 putative GEF interaction site [polypeptide binding]; other site 932920004729 GTP/Mg2+ binding site [chemical binding]; other site 932920004730 Switch I region; other site 932920004731 G2 box; other site 932920004732 G3 box; other site 932920004733 Switch II region; other site 932920004734 G4 box; other site 932920004735 G5 box; other site 932920004736 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 932920004737 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 932920004738 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 932920004739 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 932920004740 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 932920004741 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 932920004742 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 932920004743 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 932920004744 Competence protein; Region: Competence; pfam03772 932920004745 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932920004746 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 932920004747 catalytic motif [active] 932920004748 Zn binding site [ion binding]; other site 932920004749 SLBB domain; Region: SLBB; pfam10531 932920004750 comEA protein; Region: comE; TIGR01259 932920004751 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 932920004752 Methyltransferase domain; Region: Methyltransf_31; pfam13847 932920004753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920004754 S-adenosylmethionine binding site [chemical binding]; other site 932920004755 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 932920004756 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932920004757 Zn2+ binding site [ion binding]; other site 932920004758 Mg2+ binding site [ion binding]; other site 932920004759 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 932920004760 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 932920004761 active site 932920004762 (T/H)XGH motif; other site 932920004763 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 932920004764 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 932920004765 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 932920004766 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 932920004767 shikimate binding site; other site 932920004768 NAD(P) binding site [chemical binding]; other site 932920004769 GTPase YqeH; Provisional; Region: PRK13796 932920004770 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 932920004771 GTP/Mg2+ binding site [chemical binding]; other site 932920004772 G4 box; other site 932920004773 G5 box; other site 932920004774 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 932920004775 G1 box; other site 932920004776 G1 box; other site 932920004777 GTP/Mg2+ binding site [chemical binding]; other site 932920004778 G2 box; other site 932920004779 Switch I region; other site 932920004780 G2 box; other site 932920004781 Switch I region; other site 932920004782 G3 box; other site 932920004783 G3 box; other site 932920004784 Switch II region; other site 932920004785 Switch II region; other site 932920004786 G4 box; other site 932920004787 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 932920004788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920004789 motif II; other site 932920004790 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 932920004791 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 932920004792 active site 932920004793 Zn binding site [ion binding]; other site 932920004794 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 932920004795 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 932920004796 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 932920004797 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 932920004798 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 932920004799 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 932920004800 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 932920004801 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 932920004802 Sugar specificity; other site 932920004803 Pyrimidine base specificity; other site 932920004804 ATP-binding site [chemical binding]; other site 932920004805 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 932920004806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920004807 S-adenosylmethionine binding site [chemical binding]; other site 932920004808 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 932920004809 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 932920004810 dimerization interface [polypeptide binding]; other site 932920004811 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 932920004812 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 932920004813 hypothetical protein; Provisional; Region: PRK13678 932920004814 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 932920004815 hypothetical protein; Provisional; Region: PRK05473 932920004816 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 932920004817 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 932920004818 motif 1; other site 932920004819 active site 932920004820 motif 2; other site 932920004821 motif 3; other site 932920004822 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 932920004823 DHHA1 domain; Region: DHHA1; pfam02272 932920004824 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932920004825 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932920004826 Walker A/P-loop; other site 932920004827 ATP binding site [chemical binding]; other site 932920004828 Q-loop/lid; other site 932920004829 ABC transporter signature motif; other site 932920004830 Walker B; other site 932920004831 D-loop; other site 932920004832 H-loop/switch region; other site 932920004833 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932920004834 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 932920004835 FtsX-like permease family; Region: FtsX; pfam02687 932920004836 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932920004837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920004838 active site 932920004839 phosphorylation site [posttranslational modification] 932920004840 intermolecular recognition site; other site 932920004841 dimerization interface [polypeptide binding]; other site 932920004842 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932920004843 DNA binding site [nucleotide binding] 932920004844 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 932920004845 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932920004846 dimerization interface [polypeptide binding]; other site 932920004847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932920004848 dimer interface [polypeptide binding]; other site 932920004849 phosphorylation site [posttranslational modification] 932920004850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920004851 ATP binding site [chemical binding]; other site 932920004852 Mg2+ binding site [ion binding]; other site 932920004853 G-X-G motif; other site 932920004854 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 932920004855 AAA domain; Region: AAA_30; pfam13604 932920004856 Family description; Region: UvrD_C_2; pfam13538 932920004857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932920004858 binding surface 932920004859 TPR motif; other site 932920004860 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 932920004861 TPR repeat; Region: TPR_11; pfam13414 932920004862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932920004863 binding surface 932920004864 TPR motif; other site 932920004865 TPR repeat; Region: TPR_11; pfam13414 932920004866 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 932920004867 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 932920004868 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 932920004869 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 932920004870 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 932920004871 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932920004872 catalytic residue [active] 932920004873 recombination factor protein RarA; Reviewed; Region: PRK13342 932920004874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920004875 Walker A motif; other site 932920004876 ATP binding site [chemical binding]; other site 932920004877 Walker B motif; other site 932920004878 arginine finger; other site 932920004879 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 932920004880 Predicted transcriptional regulator [Transcription]; Region: COG1959 932920004881 Transcriptional regulator; Region: Rrf2; pfam02082 932920004882 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 932920004883 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 932920004884 Nitrogen regulatory protein P-II; Region: P-II; smart00938 932920004885 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 932920004886 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 932920004887 dimer interface [polypeptide binding]; other site 932920004888 anticodon binding site; other site 932920004889 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 932920004890 homodimer interface [polypeptide binding]; other site 932920004891 motif 1; other site 932920004892 active site 932920004893 motif 2; other site 932920004894 GAD domain; Region: GAD; pfam02938 932920004895 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 932920004896 active site 932920004897 motif 3; other site 932920004898 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 932920004899 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 932920004900 dimer interface [polypeptide binding]; other site 932920004901 motif 1; other site 932920004902 active site 932920004903 motif 2; other site 932920004904 motif 3; other site 932920004905 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 932920004906 anticodon binding site; other site 932920004907 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 932920004908 Bacterial SH3 domain; Region: SH3_3; pfam08239 932920004909 Bacterial SH3 domain; Region: SH3_3; pfam08239 932920004910 Bacterial SH3 domain homologues; Region: SH3b; smart00287 932920004911 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 932920004912 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 932920004913 active site 932920004914 metal binding site [ion binding]; metal-binding site 932920004915 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 932920004916 putative active site [active] 932920004917 dimerization interface [polypeptide binding]; other site 932920004918 putative tRNAtyr binding site [nucleotide binding]; other site 932920004919 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 932920004920 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932920004921 Zn2+ binding site [ion binding]; other site 932920004922 Mg2+ binding site [ion binding]; other site 932920004923 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 932920004924 synthetase active site [active] 932920004925 NTP binding site [chemical binding]; other site 932920004926 metal binding site [ion binding]; metal-binding site 932920004927 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 932920004928 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 932920004929 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932920004930 active site 932920004931 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 932920004932 DHH family; Region: DHH; pfam01368 932920004933 DHHA1 domain; Region: DHHA1; pfam02272 932920004934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 932920004935 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 932920004936 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 932920004937 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 932920004938 Protein export membrane protein; Region: SecD_SecF; cl14618 932920004939 Protein export membrane protein; Region: SecD_SecF; pfam02355 932920004940 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 932920004941 Preprotein translocase subunit; Region: YajC; pfam02699 932920004942 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 932920004943 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 932920004944 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 932920004945 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 932920004946 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 932920004947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920004948 Walker A motif; other site 932920004949 ATP binding site [chemical binding]; other site 932920004950 Walker B motif; other site 932920004951 arginine finger; other site 932920004952 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 932920004953 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 932920004954 RuvA N terminal domain; Region: RuvA_N; pfam01330 932920004955 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 932920004956 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 932920004957 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932920004958 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 932920004959 NAD binding site [chemical binding]; other site 932920004960 dimer interface [polypeptide binding]; other site 932920004961 substrate binding site [chemical binding]; other site 932920004962 hypothetical protein; Validated; Region: PRK00110 932920004963 prephenate dehydratase; Provisional; Region: PRK11898 932920004964 Prephenate dehydratase; Region: PDT; pfam00800 932920004965 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 932920004966 putative L-Phe binding site [chemical binding]; other site 932920004967 GTPase CgtA; Reviewed; Region: obgE; PRK12297 932920004968 GTP1/OBG; Region: GTP1_OBG; pfam01018 932920004969 Obg GTPase; Region: Obg; cd01898 932920004970 G1 box; other site 932920004971 GTP/Mg2+ binding site [chemical binding]; other site 932920004972 Switch I region; other site 932920004973 G2 box; other site 932920004974 G3 box; other site 932920004975 Switch II region; other site 932920004976 G4 box; other site 932920004977 G5 box; other site 932920004978 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 932920004979 glycerol kinase; Provisional; Region: glpK; PRK00047 932920004980 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 932920004981 N- and C-terminal domain interface [polypeptide binding]; other site 932920004982 active site 932920004983 MgATP binding site [chemical binding]; other site 932920004984 catalytic site [active] 932920004985 metal binding site [ion binding]; metal-binding site 932920004986 glycerol binding site [chemical binding]; other site 932920004987 homotetramer interface [polypeptide binding]; other site 932920004988 homodimer interface [polypeptide binding]; other site 932920004989 FBP binding site [chemical binding]; other site 932920004990 protein IIAGlc interface [polypeptide binding]; other site 932920004991 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 932920004992 amphipathic channel; other site 932920004993 Asn-Pro-Ala signature motifs; other site 932920004994 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 932920004995 hypothetical protein; Provisional; Region: PRK14553 932920004996 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 932920004997 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 932920004998 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 932920004999 homodimer interface [polypeptide binding]; other site 932920005000 oligonucleotide binding site [chemical binding]; other site 932920005001 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 932920005002 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 932920005003 Switch I; other site 932920005004 Switch II; other site 932920005005 septum formation inhibitor; Reviewed; Region: minC; PRK00513 932920005006 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 932920005007 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 932920005008 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 932920005009 Protein of unknown function (DUF972); Region: DUF972; pfam06156 932920005010 rod shape-determining protein MreC; Region: MreC; pfam04085 932920005011 rod shape-determining protein MreB; Provisional; Region: PRK13927 932920005012 MreB and similar proteins; Region: MreB_like; cd10225 932920005013 nucleotide binding site [chemical binding]; other site 932920005014 Mg binding site [ion binding]; other site 932920005015 putative protofilament interaction site [polypeptide binding]; other site 932920005016 RodZ interaction site [polypeptide binding]; other site 932920005017 hypothetical protein; Reviewed; Region: PRK00024 932920005018 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 932920005019 MPN+ (JAMM) motif; other site 932920005020 Zinc-binding site [ion binding]; other site 932920005021 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 932920005022 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 932920005023 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 932920005024 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932920005025 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 932920005026 AAA domain; Region: AAA_14; pfam13173 932920005027 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 932920005028 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 932920005029 active site 932920005030 HIGH motif; other site 932920005031 nucleotide binding site [chemical binding]; other site 932920005032 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 932920005033 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 932920005034 active site 932920005035 KMSKS motif; other site 932920005036 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 932920005037 tRNA binding surface [nucleotide binding]; other site 932920005038 anticodon binding site; other site 932920005039 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 932920005040 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 932920005041 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 932920005042 inhibitor-cofactor binding pocket; inhibition site 932920005043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920005044 catalytic residue [active] 932920005045 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 932920005046 dimer interface [polypeptide binding]; other site 932920005047 active site 932920005048 Schiff base residues; other site 932920005049 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 932920005050 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 932920005051 active site 932920005052 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 932920005053 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 932920005054 domain interfaces; other site 932920005055 active site 932920005056 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 932920005057 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 932920005058 tRNA; other site 932920005059 putative tRNA binding site [nucleotide binding]; other site 932920005060 putative NADP binding site [chemical binding]; other site 932920005061 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 932920005062 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 932920005063 G1 box; other site 932920005064 GTP/Mg2+ binding site [chemical binding]; other site 932920005065 Switch I region; other site 932920005066 G2 box; other site 932920005067 G3 box; other site 932920005068 Switch II region; other site 932920005069 G4 box; other site 932920005070 G5 box; other site 932920005071 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 932920005072 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 932920005073 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 932920005074 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 932920005075 active site 932920005076 dimer interface [polypeptide binding]; other site 932920005077 motif 1; other site 932920005078 motif 2; other site 932920005079 motif 3; other site 932920005080 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 932920005081 anticodon binding site; other site 932920005082 primosomal protein DnaI; Reviewed; Region: PRK08939 932920005083 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 932920005084 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 932920005085 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 932920005086 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 932920005087 ATP cone domain; Region: ATP-cone; pfam03477 932920005088 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 932920005089 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 932920005090 CoA-binding site [chemical binding]; other site 932920005091 ATP-binding [chemical binding]; other site 932920005092 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 932920005093 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 932920005094 DNA binding site [nucleotide binding] 932920005095 catalytic residue [active] 932920005096 H2TH interface [polypeptide binding]; other site 932920005097 putative catalytic residues [active] 932920005098 turnover-facilitating residue; other site 932920005099 intercalation triad [nucleotide binding]; other site 932920005100 8OG recognition residue [nucleotide binding]; other site 932920005101 putative reading head residues; other site 932920005102 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 932920005103 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 932920005104 DNA polymerase I; Provisional; Region: PRK05755 932920005105 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 932920005106 active site 932920005107 metal binding site 1 [ion binding]; metal-binding site 932920005108 putative 5' ssDNA interaction site; other site 932920005109 metal binding site 3; metal-binding site 932920005110 metal binding site 2 [ion binding]; metal-binding site 932920005111 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 932920005112 putative DNA binding site [nucleotide binding]; other site 932920005113 putative metal binding site [ion binding]; other site 932920005114 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 932920005115 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 932920005116 active site 932920005117 DNA binding site [nucleotide binding] 932920005118 catalytic site [active] 932920005119 isocitrate dehydrogenase; Reviewed; Region: PRK07006 932920005120 isocitrate dehydrogenase; Validated; Region: PRK07362 932920005121 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 932920005122 dimer interface [polypeptide binding]; other site 932920005123 Citrate synthase; Region: Citrate_synt; pfam00285 932920005124 active site 932920005125 citrylCoA binding site [chemical binding]; other site 932920005126 oxalacetate/citrate binding site [chemical binding]; other site 932920005127 coenzyme A binding site [chemical binding]; other site 932920005128 catalytic triad [active] 932920005129 Protein of unknown function (DUF441); Region: DUF441; pfam04284 932920005130 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 932920005131 pyruvate kinase; Provisional; Region: PRK06354 932920005132 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 932920005133 domain interfaces; other site 932920005134 active site 932920005135 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 932920005136 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 932920005137 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 932920005138 active site 932920005139 ADP/pyrophosphate binding site [chemical binding]; other site 932920005140 dimerization interface [polypeptide binding]; other site 932920005141 allosteric effector site; other site 932920005142 fructose-1,6-bisphosphate binding site; other site 932920005143 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 932920005144 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 932920005145 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 932920005146 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 932920005147 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 932920005148 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 932920005149 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 932920005150 active site 932920005151 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 932920005152 generic binding surface I; other site 932920005153 generic binding surface II; other site 932920005154 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 932920005155 DHH family; Region: DHH; pfam01368 932920005156 DHHA1 domain; Region: DHHA1; pfam02272 932920005157 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 932920005158 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 932920005159 active site 2 [active] 932920005160 active site 1 [active] 932920005161 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 932920005162 DNA-binding site [nucleotide binding]; DNA binding site 932920005163 DRTGG domain; Region: DRTGG; pfam07085 932920005164 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 932920005165 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 932920005166 metal-dependent hydrolase; Provisional; Region: PRK00685 932920005167 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 932920005168 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 932920005169 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 932920005170 active site 932920005171 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 932920005172 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 932920005173 hexamer interface [polypeptide binding]; other site 932920005174 ligand binding site [chemical binding]; other site 932920005175 putative active site [active] 932920005176 NAD(P) binding site [chemical binding]; other site 932920005177 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 932920005178 Ligand Binding Site [chemical binding]; other site 932920005179 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 932920005180 propionate/acetate kinase; Provisional; Region: PRK12379 932920005181 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 932920005182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920005183 S-adenosylmethionine binding site [chemical binding]; other site 932920005184 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 932920005185 dimer interface [polypeptide binding]; other site 932920005186 catalytic triad [active] 932920005187 peroxidatic and resolving cysteines [active] 932920005188 RDD family; Region: RDD; pfam06271 932920005189 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 932920005190 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 932920005191 tandem repeat interface [polypeptide binding]; other site 932920005192 oligomer interface [polypeptide binding]; other site 932920005193 active site residues [active] 932920005194 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 932920005195 ATP-NAD kinase; Region: NAD_kinase; pfam01513 932920005196 ornithine carbamoyltransferase; Provisional; Region: PRK00779 932920005197 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 932920005198 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 932920005199 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 932920005200 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 932920005201 inhibitor-cofactor binding pocket; inhibition site 932920005202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920005203 catalytic residue [active] 932920005204 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 932920005205 nucleotide binding site [chemical binding]; other site 932920005206 N-acetyl-L-glutamate binding site [chemical binding]; other site 932920005207 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 932920005208 heterotetramer interface [polypeptide binding]; other site 932920005209 active site pocket [active] 932920005210 cleavage site 932920005211 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 932920005212 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 932920005213 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 932920005214 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 932920005215 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 932920005216 Ligand Binding Site [chemical binding]; other site 932920005217 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 932920005218 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 932920005219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932920005220 catalytic residue [active] 932920005221 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 932920005222 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 932920005223 GAF domain; Region: GAF_2; pfam13185 932920005224 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 932920005225 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 932920005226 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932920005227 RNA binding surface [nucleotide binding]; other site 932920005228 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 932920005229 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 932920005230 active site 932920005231 HIGH motif; other site 932920005232 dimer interface [polypeptide binding]; other site 932920005233 KMSKS motif; other site 932920005234 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932920005235 RNA binding surface [nucleotide binding]; other site 932920005236 catabolite control protein A; Region: ccpA; TIGR01481 932920005237 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932920005238 DNA binding site [nucleotide binding] 932920005239 domain linker motif; other site 932920005240 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 932920005241 dimerization interface [polypeptide binding]; other site 932920005242 effector binding site; other site 932920005243 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 932920005244 Chorismate mutase type II; Region: CM_2; cl00693 932920005245 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 932920005246 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 932920005247 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 932920005248 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 932920005249 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 932920005250 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 932920005251 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 932920005252 dimer interface [polypeptide binding]; other site 932920005253 decamer (pentamer of dimers) interface [polypeptide binding]; other site 932920005254 catalytic triad [active] 932920005255 peroxidatic and resolving cysteines [active] 932920005256 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 932920005257 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 932920005258 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932920005259 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 932920005260 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 932920005261 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 932920005262 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 932920005263 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 932920005264 putative tRNA-binding site [nucleotide binding]; other site 932920005265 hypothetical protein; Provisional; Region: PRK13668 932920005266 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 932920005267 catalytic residues [active] 932920005268 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 932920005269 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 932920005270 oligomer interface [polypeptide binding]; other site 932920005271 active site 932920005272 metal binding site [ion binding]; metal-binding site 932920005273 Predicted small secreted protein [Function unknown]; Region: COG5584 932920005274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 932920005275 putative homodimer interface [polypeptide binding]; other site 932920005276 putative homotetramer interface [polypeptide binding]; other site 932920005277 putative allosteric switch controlling residues; other site 932920005278 putative metal binding site [ion binding]; other site 932920005279 putative homodimer-homodimer interface [polypeptide binding]; other site 932920005280 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932920005281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920005282 S-adenosylmethionine binding site [chemical binding]; other site 932920005283 Phosphotransferase enzyme family; Region: APH; pfam01636 932920005284 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 932920005285 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 932920005286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920005287 putative substrate translocation pore; other site 932920005288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920005289 MarR family; Region: MarR; pfam01047 932920005290 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 932920005291 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 932920005292 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 932920005293 homodimer interface [polypeptide binding]; other site 932920005294 substrate-cofactor binding pocket; other site 932920005295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920005296 catalytic residue [active] 932920005297 dipeptidase PepV; Reviewed; Region: PRK07318 932920005298 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 932920005299 active site 932920005300 metal binding site [ion binding]; metal-binding site 932920005301 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 932920005302 nudix motif; other site 932920005303 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 932920005304 putative substrate binding site [chemical binding]; other site 932920005305 putative ATP binding site [chemical binding]; other site 932920005306 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 932920005307 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 932920005308 active site 932920005309 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 932920005310 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 932920005311 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 932920005312 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 932920005313 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 932920005314 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 932920005315 substrate binding site [chemical binding]; other site 932920005316 active site 932920005317 catalytic residues [active] 932920005318 heterodimer interface [polypeptide binding]; other site 932920005319 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 932920005320 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 932920005321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920005322 catalytic residue [active] 932920005323 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 932920005324 active site 932920005325 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 932920005326 active site 932920005327 ribulose/triose binding site [chemical binding]; other site 932920005328 phosphate binding site [ion binding]; other site 932920005329 substrate (anthranilate) binding pocket [chemical binding]; other site 932920005330 product (indole) binding pocket [chemical binding]; other site 932920005331 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 932920005332 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 932920005333 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 932920005334 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 932920005335 Glutamine amidotransferase class-I; Region: GATase; pfam00117 932920005336 glutamine binding [chemical binding]; other site 932920005337 catalytic triad [active] 932920005338 anthranilate synthase component I; Provisional; Region: PRK13570 932920005339 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 932920005340 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 932920005341 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 932920005342 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 932920005343 putative catalytic cysteine [active] 932920005344 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 932920005345 putative active site [active] 932920005346 metal binding site [ion binding]; metal-binding site 932920005347 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 932920005348 dimer interface [polypeptide binding]; other site 932920005349 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 932920005350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920005351 Walker A/P-loop; other site 932920005352 ATP binding site [chemical binding]; other site 932920005353 Q-loop/lid; other site 932920005354 ABC transporter signature motif; other site 932920005355 Walker B; other site 932920005356 D-loop; other site 932920005357 H-loop/switch region; other site 932920005358 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 932920005359 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 932920005360 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 932920005361 putative dimer interface [polypeptide binding]; other site 932920005362 catalytic triad [active] 932920005363 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 932920005364 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 932920005365 aconitate hydratase; Validated; Region: PRK09277 932920005366 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 932920005367 substrate binding site [chemical binding]; other site 932920005368 ligand binding site [chemical binding]; other site 932920005369 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 932920005370 substrate binding site [chemical binding]; other site 932920005371 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 932920005372 Heat induced stress protein YflT; Region: YflT; pfam11181 932920005373 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 932920005374 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 932920005375 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932920005376 ATP binding site [chemical binding]; other site 932920005377 putative Mg++ binding site [ion binding]; other site 932920005378 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932920005379 nucleotide binding region [chemical binding]; other site 932920005380 ATP-binding site [chemical binding]; other site 932920005381 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 932920005382 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 932920005383 Walker A/P-loop; other site 932920005384 ATP binding site [chemical binding]; other site 932920005385 Q-loop/lid; other site 932920005386 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 932920005387 ABC transporter signature motif; other site 932920005388 Walker B; other site 932920005389 D-loop; other site 932920005390 H-loop/switch region; other site 932920005391 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 932920005392 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 932920005393 active site 932920005394 metal binding site [ion binding]; metal-binding site 932920005395 DNA binding site [nucleotide binding] 932920005396 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 932920005397 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 932920005398 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 932920005399 putative acyl-acceptor binding pocket; other site 932920005400 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 932920005401 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 932920005402 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932920005403 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932920005404 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 932920005405 Walker A/P-loop; other site 932920005406 ATP binding site [chemical binding]; other site 932920005407 Q-loop/lid; other site 932920005408 ABC transporter signature motif; other site 932920005409 Walker B; other site 932920005410 D-loop; other site 932920005411 H-loop/switch region; other site 932920005412 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932920005413 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 932920005414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920005415 Walker A/P-loop; other site 932920005416 ATP binding site [chemical binding]; other site 932920005417 Q-loop/lid; other site 932920005418 ABC transporter signature motif; other site 932920005419 Walker B; other site 932920005420 D-loop; other site 932920005421 H-loop/switch region; other site 932920005422 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 932920005423 active site 932920005424 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 932920005425 elongation factor Ts; Provisional; Region: tsf; PRK09377 932920005426 UBA/TS-N domain; Region: UBA; pfam00627 932920005427 Elongation factor TS; Region: EF_TS; pfam00889 932920005428 Elongation factor TS; Region: EF_TS; pfam00889 932920005429 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 932920005430 rRNA interaction site [nucleotide binding]; other site 932920005431 S8 interaction site; other site 932920005432 putative laminin-1 binding site; other site 932920005433 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 932920005434 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 932920005435 HIGH motif; other site 932920005436 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 932920005437 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 932920005438 active site 932920005439 KMSKS motif; other site 932920005440 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 932920005441 tRNA binding surface [nucleotide binding]; other site 932920005442 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 932920005443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920005444 S-adenosylmethionine binding site [chemical binding]; other site 932920005445 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 932920005446 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 932920005447 active site 932920005448 dimer interface [polypeptide binding]; other site 932920005449 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 932920005450 Ligand Binding Site [chemical binding]; other site 932920005451 Molecular Tunnel; other site 932920005452 S-adenosylmethionine synthetase; Validated; Region: PRK05250 932920005453 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 932920005454 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 932920005455 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 932920005456 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932920005457 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932920005458 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 932920005459 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932920005460 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 932920005461 NAD binding site [chemical binding]; other site 932920005462 dimer interface [polypeptide binding]; other site 932920005463 substrate binding site [chemical binding]; other site 932920005464 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 932920005465 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 932920005466 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 932920005467 nudix motif; other site 932920005468 Uncharacterized conserved protein [Function unknown]; Region: COG0759 932920005469 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 932920005470 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 932920005471 metal binding site [ion binding]; metal-binding site 932920005472 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 932920005473 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 932920005474 acyl-activating enzyme (AAE) consensus motif; other site 932920005475 putative AMP binding site [chemical binding]; other site 932920005476 putative active site [active] 932920005477 putative CoA binding site [chemical binding]; other site 932920005478 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 932920005479 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 932920005480 substrate binding site [chemical binding]; other site 932920005481 oxyanion hole (OAH) forming residues; other site 932920005482 trimer interface [polypeptide binding]; other site 932920005483 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 932920005484 Serine hydrolase (FSH1); Region: FSH1; pfam03959 932920005485 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 932920005486 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 932920005487 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 932920005488 dimer interface [polypeptide binding]; other site 932920005489 tetramer interface [polypeptide binding]; other site 932920005490 PYR/PP interface [polypeptide binding]; other site 932920005491 TPP binding site [chemical binding]; other site 932920005492 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 932920005493 TPP-binding site; other site 932920005494 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 932920005495 chorismate binding enzyme; Region: Chorismate_bind; cl10555 932920005496 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 932920005497 UbiA prenyltransferase family; Region: UbiA; pfam01040 932920005498 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 932920005499 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 932920005500 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 932920005501 FAD binding site [chemical binding]; other site 932920005502 cystathionine beta-lyase; Provisional; Region: PRK08064 932920005503 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 932920005504 homodimer interface [polypeptide binding]; other site 932920005505 substrate-cofactor binding pocket; other site 932920005506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920005507 catalytic residue [active] 932920005508 cystathionine gamma-synthase; Reviewed; Region: PRK08247 932920005509 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 932920005510 homodimer interface [polypeptide binding]; other site 932920005511 substrate-cofactor binding pocket; other site 932920005512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920005513 catalytic residue [active] 932920005514 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 932920005515 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 932920005516 THF binding site; other site 932920005517 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 932920005518 substrate binding site [chemical binding]; other site 932920005519 THF binding site; other site 932920005520 zinc-binding site [ion binding]; other site 932920005521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920005522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920005523 putative substrate translocation pore; other site 932920005524 ferric uptake regulator; Provisional; Region: fur; PRK09462 932920005525 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 932920005526 metal binding site 2 [ion binding]; metal-binding site 932920005527 putative DNA binding helix; other site 932920005528 metal binding site 1 [ion binding]; metal-binding site 932920005529 dimer interface [polypeptide binding]; other site 932920005530 structural Zn2+ binding site [ion binding]; other site 932920005531 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 932920005532 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 932920005533 NAD binding site [chemical binding]; other site 932920005534 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 932920005535 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 932920005536 inhibitor-cofactor binding pocket; inhibition site 932920005537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920005538 catalytic residue [active] 932920005539 Predicted membrane protein [Function unknown]; Region: COG4129 932920005540 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 932920005541 hypothetical protein; Provisional; Region: PRK13662 932920005542 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 932920005543 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 932920005544 putative NAD(P) binding site [chemical binding]; other site 932920005545 active site 932920005546 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 932920005547 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 932920005548 minor groove reading motif; other site 932920005549 helix-hairpin-helix signature motif; other site 932920005550 substrate binding pocket [chemical binding]; other site 932920005551 active site 932920005552 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 932920005553 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 932920005554 DNA binding and oxoG recognition site [nucleotide binding] 932920005555 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 932920005556 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 932920005557 trimer interface [polypeptide binding]; other site 932920005558 active site 932920005559 WVELL protein; Region: WVELL; pfam14043 932920005560 recombination regulator RecX; Provisional; Region: recX; PRK14135 932920005561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932920005562 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 932920005563 NAD(P) binding site [chemical binding]; other site 932920005564 active site 932920005565 Predicted integral membrane protein [Function unknown]; Region: COG0392 932920005566 Uncharacterized conserved protein [Function unknown]; Region: COG2898 932920005567 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 932920005568 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 932920005569 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 932920005570 Cation efflux family; Region: Cation_efflux; pfam01545 932920005571 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 932920005572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 932920005573 PAS fold; Region: PAS_4; pfam08448 932920005574 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932920005575 putative active site [active] 932920005576 heme pocket [chemical binding]; other site 932920005577 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 932920005578 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932920005579 dimer interface [polypeptide binding]; other site 932920005580 putative CheW interface [polypeptide binding]; other site 932920005581 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 932920005582 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 932920005583 dimer interface [polypeptide binding]; other site 932920005584 active site 932920005585 Mn binding site [ion binding]; other site 932920005586 TRAM domain; Region: TRAM; cl01282 932920005587 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 932920005588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920005589 S-adenosylmethionine binding site [chemical binding]; other site 932920005590 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 932920005591 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 932920005592 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 932920005593 Substrate-binding site [chemical binding]; other site 932920005594 Substrate specificity [chemical binding]; other site 932920005595 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 932920005596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 932920005597 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 932920005598 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 932920005599 active site 932920005600 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 932920005601 flavodoxin, short chain; Region: flav_short; TIGR01753 932920005602 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 932920005603 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 932920005604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920005605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920005606 putative substrate translocation pore; other site 932920005607 rod-share determining protein MreBH; Provisional; Region: PRK13929 932920005608 MreB and similar proteins; Region: MreB_like; cd10225 932920005609 nucleotide binding site [chemical binding]; other site 932920005610 Mg binding site [ion binding]; other site 932920005611 putative protofilament interaction site [polypeptide binding]; other site 932920005612 RodZ interaction site [polypeptide binding]; other site 932920005613 Methyltransferase domain; Region: Methyltransf_31; pfam13847 932920005614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920005615 S-adenosylmethionine binding site [chemical binding]; other site 932920005616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932920005617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932920005618 Uncharacterized conserved protein [Function unknown]; Region: COG4748 932920005619 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 932920005620 Uncharacterized conserved protein [Function unknown]; Region: COG3589 932920005621 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 932920005622 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932920005623 methionine cluster; other site 932920005624 active site 932920005625 phosphorylation site [posttranslational modification] 932920005626 metal binding site [ion binding]; metal-binding site 932920005627 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932920005628 active site 932920005629 P-loop; other site 932920005630 phosphorylation site [posttranslational modification] 932920005631 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 932920005632 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 932920005633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920005634 Walker A motif; other site 932920005635 ATP binding site [chemical binding]; other site 932920005636 Walker B motif; other site 932920005637 arginine finger; other site 932920005638 Transcriptional antiterminator [Transcription]; Region: COG3933 932920005639 PRD domain; Region: PRD; pfam00874 932920005640 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 932920005641 active pocket/dimerization site; other site 932920005642 active site 932920005643 phosphorylation site [posttranslational modification] 932920005644 PRD domain; Region: PRD; pfam00874 932920005645 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 932920005646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 932920005647 ATP binding site [chemical binding]; other site 932920005648 putative Mg++ binding site [ion binding]; other site 932920005649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932920005650 nucleotide binding region [chemical binding]; other site 932920005651 ATP-binding site [chemical binding]; other site 932920005652 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 932920005653 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 932920005654 Walker A/P-loop; other site 932920005655 ATP binding site [chemical binding]; other site 932920005656 Q-loop/lid; other site 932920005657 ABC transporter signature motif; other site 932920005658 Walker B; other site 932920005659 D-loop; other site 932920005660 H-loop/switch region; other site 932920005661 Predicted transcriptional regulators [Transcription]; Region: COG1725 932920005662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920005663 DNA-binding site [nucleotide binding]; DNA binding site 932920005664 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932920005665 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932920005666 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932920005667 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932920005668 DNA binding site [nucleotide binding] 932920005669 domain linker motif; other site 932920005670 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 932920005671 dimerization interface [polypeptide binding]; other site 932920005672 ligand binding site [chemical binding]; other site 932920005673 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 932920005674 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 932920005675 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 932920005676 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 932920005677 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 932920005678 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932920005679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920005680 dimer interface [polypeptide binding]; other site 932920005681 conserved gate region; other site 932920005682 putative PBP binding loops; other site 932920005683 ABC-ATPase subunit interface; other site 932920005684 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932920005685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920005686 dimer interface [polypeptide binding]; other site 932920005687 conserved gate region; other site 932920005688 putative PBP binding loops; other site 932920005689 ABC-ATPase subunit interface; other site 932920005690 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 932920005691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 932920005692 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 932920005693 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 932920005694 active site 932920005695 dimer interface [polypeptide binding]; other site 932920005696 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 932920005697 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 932920005698 active site 932920005699 FMN binding site [chemical binding]; other site 932920005700 substrate binding site [chemical binding]; other site 932920005701 3Fe-4S cluster binding site [ion binding]; other site 932920005702 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 932920005703 domain interface; other site 932920005704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932920005705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932920005706 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 932920005707 putative dimerization interface [polypeptide binding]; other site 932920005708 Predicted acetyltransferase [General function prediction only]; Region: COG3153 932920005709 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 932920005710 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 932920005711 putative active site [active] 932920005712 metal binding site [ion binding]; metal-binding site 932920005713 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932920005714 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932920005715 substrate binding pocket [chemical binding]; other site 932920005716 membrane-bound complex binding site; other site 932920005717 hinge residues; other site 932920005718 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932920005719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920005720 Walker A/P-loop; other site 932920005721 ATP binding site [chemical binding]; other site 932920005722 Q-loop/lid; other site 932920005723 ABC transporter signature motif; other site 932920005724 Walker B; other site 932920005725 D-loop; other site 932920005726 H-loop/switch region; other site 932920005727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920005728 dimer interface [polypeptide binding]; other site 932920005729 conserved gate region; other site 932920005730 putative PBP binding loops; other site 932920005731 ABC-ATPase subunit interface; other site 932920005732 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 932920005733 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 932920005734 dimer interface [polypeptide binding]; other site 932920005735 phosphorylation site [posttranslational modification] 932920005736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920005737 ATP binding site [chemical binding]; other site 932920005738 Mg2+ binding site [ion binding]; other site 932920005739 G-X-G motif; other site 932920005740 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 932920005741 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 932920005742 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 932920005743 active site 932920005744 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 932920005745 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 932920005746 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 932920005747 putative NAD(P) binding site [chemical binding]; other site 932920005748 active site 932920005749 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932920005750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920005751 active site 932920005752 phosphorylation site [posttranslational modification] 932920005753 intermolecular recognition site; other site 932920005754 dimerization interface [polypeptide binding]; other site 932920005755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932920005756 DNA binding site [nucleotide binding] 932920005757 FtsX-like permease family; Region: FtsX; pfam02687 932920005758 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 932920005759 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932920005760 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932920005761 Walker A/P-loop; other site 932920005762 ATP binding site [chemical binding]; other site 932920005763 Q-loop/lid; other site 932920005764 ABC transporter signature motif; other site 932920005765 Walker B; other site 932920005766 D-loop; other site 932920005767 H-loop/switch region; other site 932920005768 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 932920005769 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 932920005770 ADP binding site [chemical binding]; other site 932920005771 magnesium binding site [ion binding]; other site 932920005772 putative shikimate binding site; other site 932920005773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 932920005774 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 932920005775 TRAM domain; Region: TRAM; pfam01938 932920005776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920005777 S-adenosylmethionine binding site [chemical binding]; other site 932920005778 putative lipid kinase; Reviewed; Region: PRK13337 932920005779 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 932920005780 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 932920005781 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 932920005782 GatB domain; Region: GatB_Yqey; pfam02637 932920005783 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 932920005784 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 932920005785 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 932920005786 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 932920005787 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 932920005788 putative dimer interface [polypeptide binding]; other site 932920005789 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 932920005790 putative dimer interface [polypeptide binding]; other site 932920005791 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 932920005792 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 932920005793 nucleotide binding pocket [chemical binding]; other site 932920005794 K-X-D-G motif; other site 932920005795 catalytic site [active] 932920005796 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 932920005797 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 932920005798 Dimer interface [polypeptide binding]; other site 932920005799 BRCT sequence motif; other site 932920005800 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 932920005801 Part of AAA domain; Region: AAA_19; pfam13245 932920005802 Family description; Region: UvrD_C_2; pfam13538 932920005803 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 932920005804 PcrB family; Region: PcrB; pfam01884 932920005805 substrate binding site [chemical binding]; other site 932920005806 putative active site [active] 932920005807 dimer interface [polypeptide binding]; other site 932920005808 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 932920005809 Na2 binding site [ion binding]; other site 932920005810 putative substrate binding site 1 [chemical binding]; other site 932920005811 Na binding site 1 [ion binding]; other site 932920005812 putative substrate binding site 2 [chemical binding]; other site 932920005813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 932920005814 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 932920005815 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 932920005816 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 932920005817 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 932920005818 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 932920005819 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 932920005820 purine monophosphate binding site [chemical binding]; other site 932920005821 dimer interface [polypeptide binding]; other site 932920005822 putative catalytic residues [active] 932920005823 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 932920005824 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 932920005825 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 932920005826 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 932920005827 active site 932920005828 substrate binding site [chemical binding]; other site 932920005829 cosubstrate binding site; other site 932920005830 catalytic site [active] 932920005831 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 932920005832 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 932920005833 dimerization interface [polypeptide binding]; other site 932920005834 putative ATP binding site [chemical binding]; other site 932920005835 amidophosphoribosyltransferase; Provisional; Region: PRK06781 932920005836 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 932920005837 active site 932920005838 tetramer interface [polypeptide binding]; other site 932920005839 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932920005840 active site 932920005841 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 932920005842 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 932920005843 dimerization interface [polypeptide binding]; other site 932920005844 ATP binding site [chemical binding]; other site 932920005845 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 932920005846 dimerization interface [polypeptide binding]; other site 932920005847 ATP binding site [chemical binding]; other site 932920005848 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 932920005849 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 932920005850 putative active site [active] 932920005851 catalytic triad [active] 932920005852 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 932920005853 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 932920005854 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 932920005855 ATP binding site [chemical binding]; other site 932920005856 active site 932920005857 substrate binding site [chemical binding]; other site 932920005858 adenylosuccinate lyase; Provisional; Region: PRK07492 932920005859 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 932920005860 tetramer interface [polypeptide binding]; other site 932920005861 active site 932920005862 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 932920005863 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 932920005864 NAD binding site [chemical binding]; other site 932920005865 ATP-grasp domain; Region: ATP-grasp; pfam02222 932920005866 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 932920005867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 932920005868 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 932920005869 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 932920005870 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932920005871 Zn2+ binding site [ion binding]; other site 932920005872 Mg2+ binding site [ion binding]; other site 932920005873 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 932920005874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920005875 Walker A/P-loop; other site 932920005876 ATP binding site [chemical binding]; other site 932920005877 Q-loop/lid; other site 932920005878 ABC transporter signature motif; other site 932920005879 Walker B; other site 932920005880 D-loop; other site 932920005881 H-loop/switch region; other site 932920005882 peptidase T; Region: peptidase-T; TIGR01882 932920005883 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 932920005884 metal binding site [ion binding]; metal-binding site 932920005885 dimer interface [polypeptide binding]; other site 932920005886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 932920005887 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 932920005888 active site 932920005889 putative catalytic site [active] 932920005890 DNA binding site [nucleotide binding] 932920005891 putative phosphate binding site [ion binding]; other site 932920005892 metal binding site A [ion binding]; metal-binding site 932920005893 AP binding site [nucleotide binding]; other site 932920005894 metal binding site B [ion binding]; metal-binding site 932920005895 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 932920005896 23S rRNA binding site [nucleotide binding]; other site 932920005897 L21 binding site [polypeptide binding]; other site 932920005898 L13 binding site [polypeptide binding]; other site 932920005899 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 932920005900 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 932920005901 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 932920005902 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 932920005903 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932920005904 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920005905 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932920005906 Substrate binding site [chemical binding]; other site 932920005907 Leucine rich repeat; Region: LRR_8; pfam13855 932920005908 LRR adjacent; Region: LRR_adjacent; pfam08191 932920005909 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 932920005910 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 932920005911 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 932920005912 DNA binding residues [nucleotide binding] 932920005913 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 932920005914 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 932920005915 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932920005916 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 932920005917 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 932920005918 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 932920005919 RimM N-terminal domain; Region: RimM; pfam01782 932920005920 PRC-barrel domain; Region: PRC; pfam05239 932920005921 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 932920005922 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 932920005923 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 932920005924 catalytic triad [active] 932920005925 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 932920005926 KH domain; Region: KH_4; pfam13083 932920005927 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 932920005928 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 932920005929 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 932920005930 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 932920005931 signal recognition particle protein; Provisional; Region: PRK10867 932920005932 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 932920005933 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 932920005934 P loop; other site 932920005935 GTP binding site [chemical binding]; other site 932920005936 Signal peptide binding domain; Region: SRP_SPB; pfam02978 932920005937 putative DNA-binding protein; Validated; Region: PRK00118 932920005938 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 932920005939 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 932920005940 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 932920005941 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 932920005942 P loop; other site 932920005943 GTP binding site [chemical binding]; other site 932920005944 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 932920005945 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 932920005946 Walker A/P-loop; other site 932920005947 ATP binding site [chemical binding]; other site 932920005948 Q-loop/lid; other site 932920005949 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 932920005950 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 932920005951 ABC transporter signature motif; other site 932920005952 Walker B; other site 932920005953 D-loop; other site 932920005954 H-loop/switch region; other site 932920005955 ribonuclease III; Reviewed; Region: rnc; PRK00102 932920005956 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 932920005957 dimerization interface [polypeptide binding]; other site 932920005958 active site 932920005959 metal binding site [ion binding]; metal-binding site 932920005960 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 932920005961 dsRNA binding site [nucleotide binding]; other site 932920005962 acyl carrier protein; Provisional; Region: acpP; PRK00982 932920005963 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 932920005964 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 932920005965 NAD(P) binding site [chemical binding]; other site 932920005966 homotetramer interface [polypeptide binding]; other site 932920005967 homodimer interface [polypeptide binding]; other site 932920005968 active site 932920005969 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 932920005970 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 932920005971 putative phosphate acyltransferase; Provisional; Region: PRK05331 932920005972 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 932920005973 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 932920005974 active site 2 [active] 932920005975 active site 1 [active] 932920005976 Y-family of DNA polymerases; Region: PolY; cl12025 932920005977 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 932920005978 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 932920005979 generic binding surface II; other site 932920005980 ssDNA binding site; other site 932920005981 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932920005982 ATP binding site [chemical binding]; other site 932920005983 putative Mg++ binding site [ion binding]; other site 932920005984 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932920005985 nucleotide binding region [chemical binding]; other site 932920005986 ATP-binding site [chemical binding]; other site 932920005987 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 932920005988 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 932920005989 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 932920005990 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 932920005991 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 932920005992 putative L-serine binding site [chemical binding]; other site 932920005993 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 932920005994 DAK2 domain; Region: Dak2; pfam02734 932920005995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 932920005996 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 932920005997 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 932920005998 Thiamine pyrophosphokinase; Region: TPK; cd07995 932920005999 active site 932920006000 dimerization interface [polypeptide binding]; other site 932920006001 thiamine binding site [chemical binding]; other site 932920006002 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 932920006003 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 932920006004 substrate binding site [chemical binding]; other site 932920006005 hexamer interface [polypeptide binding]; other site 932920006006 metal binding site [ion binding]; metal-binding site 932920006007 GTPase RsgA; Reviewed; Region: PRK00098 932920006008 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 932920006009 RNA binding site [nucleotide binding]; other site 932920006010 homodimer interface [polypeptide binding]; other site 932920006011 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 932920006012 GTPase/Zn-binding domain interface [polypeptide binding]; other site 932920006013 GTP/Mg2+ binding site [chemical binding]; other site 932920006014 G4 box; other site 932920006015 G1 box; other site 932920006016 Switch I region; other site 932920006017 G2 box; other site 932920006018 G3 box; other site 932920006019 Switch II region; other site 932920006020 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 932920006021 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 932920006022 active site 932920006023 ATP binding site [chemical binding]; other site 932920006024 substrate binding site [chemical binding]; other site 932920006025 activation loop (A-loop); other site 932920006026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 932920006027 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 932920006028 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 932920006029 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 932920006030 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 932920006031 Protein phosphatase 2C; Region: PP2C; pfam00481 932920006032 active site 932920006033 16S rRNA methyltransferase B; Provisional; Region: PRK14902 932920006034 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 932920006035 putative RNA binding site [nucleotide binding]; other site 932920006036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920006037 S-adenosylmethionine binding site [chemical binding]; other site 932920006038 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 932920006039 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 932920006040 putative active site [active] 932920006041 substrate binding site [chemical binding]; other site 932920006042 putative cosubstrate binding site; other site 932920006043 catalytic site [active] 932920006044 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 932920006045 substrate binding site [chemical binding]; other site 932920006046 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 932920006047 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932920006048 ATP binding site [chemical binding]; other site 932920006049 putative Mg++ binding site [ion binding]; other site 932920006050 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932920006051 ATP-binding site [chemical binding]; other site 932920006052 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 932920006053 Flavoprotein; Region: Flavoprotein; pfam02441 932920006054 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 932920006055 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 932920006056 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 932920006057 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 932920006058 catalytic site [active] 932920006059 G-X2-G-X-G-K; other site 932920006060 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 932920006061 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 932920006062 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 932920006063 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 932920006064 Domain of unknown function (DUF814); Region: DUF814; pfam05670 932920006065 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 932920006066 putative NAD(P) binding site [chemical binding]; other site 932920006067 homodimer interface [polypeptide binding]; other site 932920006068 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932920006069 active site 932920006070 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 932920006071 active site 932920006072 dimer interface [polypeptide binding]; other site 932920006073 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 932920006074 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 932920006075 heterodimer interface [polypeptide binding]; other site 932920006076 active site 932920006077 FMN binding site [chemical binding]; other site 932920006078 homodimer interface [polypeptide binding]; other site 932920006079 substrate binding site [chemical binding]; other site 932920006080 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 932920006081 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 932920006082 FAD binding pocket [chemical binding]; other site 932920006083 FAD binding motif [chemical binding]; other site 932920006084 phosphate binding motif [ion binding]; other site 932920006085 beta-alpha-beta structure motif; other site 932920006086 NAD binding pocket [chemical binding]; other site 932920006087 Iron coordination center [ion binding]; other site 932920006088 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 932920006089 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 932920006090 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 932920006091 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 932920006092 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 932920006093 ATP-grasp domain; Region: ATP-grasp_4; cl17255 932920006094 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 932920006095 IMP binding site; other site 932920006096 dimer interface [polypeptide binding]; other site 932920006097 interdomain contacts; other site 932920006098 partial ornithine binding site; other site 932920006099 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 932920006100 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 932920006101 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 932920006102 catalytic site [active] 932920006103 subunit interface [polypeptide binding]; other site 932920006104 dihydroorotase; Validated; Region: pyrC; PRK09357 932920006105 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 932920006106 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 932920006107 active site 932920006108 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 932920006109 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 932920006110 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 932920006111 uracil transporter; Provisional; Region: PRK10720 932920006112 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 932920006113 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932920006114 active site 932920006115 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 932920006116 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 932920006117 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932920006118 RNA binding surface [nucleotide binding]; other site 932920006119 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 932920006120 active site 932920006121 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 932920006122 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 932920006123 Sulfate transporter family; Region: Sulfate_transp; pfam00916 932920006124 multidrug efflux protein; Reviewed; Region: PRK01766 932920006125 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 932920006126 cation binding site [ion binding]; other site 932920006127 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 932920006128 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 932920006129 metal binding site [ion binding]; metal-binding site 932920006130 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 932920006131 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932920006132 ABC-ATPase subunit interface; other site 932920006133 dimer interface [polypeptide binding]; other site 932920006134 putative PBP binding regions; other site 932920006135 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 932920006136 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 932920006137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932920006138 MarR family; Region: MarR; pfam01047 932920006139 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 932920006140 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 932920006141 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 932920006142 protein binding site [polypeptide binding]; other site 932920006143 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 932920006144 Catalytic dyad [active] 932920006145 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 932920006146 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 932920006147 metal-binding site [ion binding] 932920006148 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 932920006149 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 932920006150 metal-binding site [ion binding] 932920006151 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932920006152 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920006153 motif II; other site 932920006154 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 932920006155 putative homodimer interface [polypeptide binding]; other site 932920006156 putative homotetramer interface [polypeptide binding]; other site 932920006157 putative allosteric switch controlling residues; other site 932920006158 putative metal binding site [ion binding]; other site 932920006159 putative homodimer-homodimer interface [polypeptide binding]; other site 932920006160 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 932920006161 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 932920006162 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 932920006163 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 932920006164 hypothetical protein; Provisional; Region: PRK13672 932920006165 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932920006166 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932920006167 methionine sulfoxide reductase B; Provisional; Region: PRK00222 932920006168 SelR domain; Region: SelR; pfam01641 932920006169 methionine sulfoxide reductase A; Provisional; Region: PRK14054 932920006170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 932920006171 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 932920006172 active site 932920006173 catalytic triad [active] 932920006174 oxyanion hole [active] 932920006175 EDD domain protein, DegV family; Region: DegV; TIGR00762 932920006176 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 932920006177 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 932920006178 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 932920006179 HTH domain; Region: HTH_11; pfam08279 932920006180 FOG: CBS domain [General function prediction only]; Region: COG0517 932920006181 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 932920006182 PEP synthetase regulatory protein; Provisional; Region: PRK05339 932920006183 pyruvate phosphate dikinase; Provisional; Region: PRK09279 932920006184 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 932920006185 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 932920006186 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 932920006187 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932920006188 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 932920006189 Predicted membrane protein [Function unknown]; Region: COG4129 932920006190 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 932920006191 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 932920006192 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 932920006193 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 932920006194 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 932920006195 active site 932920006196 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 932920006197 substrate binding site [chemical binding]; other site 932920006198 metal binding site [ion binding]; metal-binding site 932920006199 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 932920006200 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 932920006201 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 932920006202 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 932920006203 folate binding site [chemical binding]; other site 932920006204 NADP+ binding site [chemical binding]; other site 932920006205 thymidylate synthase; Region: thym_sym; TIGR03284 932920006206 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 932920006207 dimerization interface [polypeptide binding]; other site 932920006208 active site 932920006209 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 932920006210 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920006211 Walker A/P-loop; other site 932920006212 ATP binding site [chemical binding]; other site 932920006213 Q-loop/lid; other site 932920006214 ABC transporter signature motif; other site 932920006215 Walker B; other site 932920006216 D-loop; other site 932920006217 H-loop/switch region; other site 932920006218 ABC transporter; Region: ABC_tran_2; pfam12848 932920006219 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932920006220 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 932920006221 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 932920006222 Potassium binding sites [ion binding]; other site 932920006223 Cesium cation binding sites [ion binding]; other site 932920006224 manganese transport transcriptional regulator; Provisional; Region: PRK03902 932920006225 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 932920006226 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 932920006227 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 932920006228 DNA-binding site [nucleotide binding]; DNA binding site 932920006229 RNA-binding motif; other site 932920006230 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 932920006231 RNA/DNA hybrid binding site [nucleotide binding]; other site 932920006232 active site 932920006233 5'-3' exonuclease; Region: 53EXOc; smart00475 932920006234 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 932920006235 active site 932920006236 metal binding site 1 [ion binding]; metal-binding site 932920006237 putative 5' ssDNA interaction site; other site 932920006238 metal binding site 3; metal-binding site 932920006239 metal binding site 2 [ion binding]; metal-binding site 932920006240 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 932920006241 putative DNA binding site [nucleotide binding]; other site 932920006242 putative metal binding site [ion binding]; other site 932920006243 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 932920006244 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 932920006245 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 932920006246 putative active site [active] 932920006247 xanthine permease; Region: pbuX; TIGR03173 932920006248 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932920006249 active site 932920006250 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 932920006251 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 932920006252 active site 932920006253 Zn binding site [ion binding]; other site 932920006254 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 932920006255 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 932920006256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 932920006257 cell division protein GpsB; Provisional; Region: PRK14127 932920006258 DivIVA domain; Region: DivI1A_domain; TIGR03544 932920006259 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 932920006260 hypothetical protein; Provisional; Region: PRK13660 932920006261 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 932920006262 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 932920006263 Transglycosylase; Region: Transgly; pfam00912 932920006264 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 932920006265 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 932920006266 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 932920006267 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 932920006268 minor groove reading motif; other site 932920006269 helix-hairpin-helix signature motif; other site 932920006270 substrate binding pocket [chemical binding]; other site 932920006271 active site 932920006272 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 932920006273 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 932920006274 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 932920006275 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 932920006276 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 932920006277 putative dimer interface [polypeptide binding]; other site 932920006278 putative anticodon binding site; other site 932920006279 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 932920006280 homodimer interface [polypeptide binding]; other site 932920006281 motif 1; other site 932920006282 motif 2; other site 932920006283 active site 932920006284 motif 3; other site 932920006285 aspartate aminotransferase; Provisional; Region: PRK05764 932920006286 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932920006287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920006288 homodimer interface [polypeptide binding]; other site 932920006289 catalytic residue [active] 932920006290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 932920006291 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 932920006292 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 932920006293 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 932920006294 active site 932920006295 catalytic site [active] 932920006296 substrate binding site [chemical binding]; other site 932920006297 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 932920006298 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 932920006299 putative Mg++ binding site [ion binding]; other site 932920006300 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 932920006301 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 932920006302 tetramerization interface [polypeptide binding]; other site 932920006303 active site 932920006304 pantoate--beta-alanine ligase; Region: panC; TIGR00018 932920006305 Pantoate-beta-alanine ligase; Region: PanC; cd00560 932920006306 active site 932920006307 ATP-binding site [chemical binding]; other site 932920006308 pantoate-binding site; other site 932920006309 HXXH motif; other site 932920006310 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 932920006311 active site 932920006312 oligomerization interface [polypeptide binding]; other site 932920006313 metal binding site [ion binding]; metal-binding site 932920006314 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 932920006315 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 932920006316 catalytic residues [active] 932920006317 Biotin operon repressor [Transcription]; Region: BirA; COG1654 932920006318 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 932920006319 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 932920006320 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 932920006321 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 932920006322 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 932920006323 active site 932920006324 NTP binding site [chemical binding]; other site 932920006325 metal binding triad [ion binding]; metal-binding site 932920006326 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 932920006327 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 932920006328 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 932920006329 active site 932920006330 dimer interfaces [polypeptide binding]; other site 932920006331 catalytic residues [active] 932920006332 dihydrodipicolinate reductase; Provisional; Region: PRK00048 932920006333 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 932920006334 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 932920006335 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 932920006336 homodimer interface [polypeptide binding]; other site 932920006337 metal binding site [ion binding]; metal-binding site 932920006338 Uncharacterized conserved protein [Function unknown]; Region: COG1284 932920006339 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 932920006340 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 932920006341 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 932920006342 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 932920006343 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932920006344 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932920006345 metal binding site [ion binding]; metal-binding site 932920006346 active site 932920006347 I-site; other site 932920006348 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 932920006349 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932920006350 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932920006351 metal binding site [ion binding]; metal-binding site 932920006352 active site 932920006353 I-site; other site 932920006354 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932920006355 malate dehydrogenase; Provisional; Region: PRK13529 932920006356 Malic enzyme, N-terminal domain; Region: malic; pfam00390 932920006357 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 932920006358 NAD(P) binding pocket [chemical binding]; other site 932920006359 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 932920006360 Beta-lactamase; Region: Beta-lactamase; pfam00144 932920006361 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 932920006362 Pyruvate formate lyase 1; Region: PFL1; cd01678 932920006363 coenzyme A binding site [chemical binding]; other site 932920006364 active site 932920006365 catalytic residues [active] 932920006366 glycine loop; other site 932920006367 HI0933-like protein; Region: HI0933_like; pfam03486 932920006368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932920006369 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 932920006370 Predicted membrane protein [Function unknown]; Region: COG4347 932920006371 hypothetical protein; Provisional; Region: PRK03636 932920006372 UPF0302 domain; Region: UPF0302; pfam08864 932920006373 IDEAL domain; Region: IDEAL; pfam08858 932920006374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 932920006375 binding surface 932920006376 TPR motif; other site 932920006377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932920006378 binding surface 932920006379 Tetratricopeptide repeat; Region: TPR_16; pfam13432 932920006380 TPR motif; other site 932920006381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 932920006382 binding surface 932920006383 TPR motif; other site 932920006384 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 932920006385 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 932920006386 hinge; other site 932920006387 active site 932920006388 prephenate dehydrogenase; Validated; Region: PRK06545 932920006389 prephenate dehydrogenase; Validated; Region: PRK08507 932920006390 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 932920006391 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 932920006392 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932920006393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920006394 homodimer interface [polypeptide binding]; other site 932920006395 catalytic residue [active] 932920006396 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 932920006397 homotrimer interaction site [polypeptide binding]; other site 932920006398 active site 932920006399 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 932920006400 active site 932920006401 dimer interface [polypeptide binding]; other site 932920006402 metal binding site [ion binding]; metal-binding site 932920006403 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 932920006404 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 932920006405 Tetramer interface [polypeptide binding]; other site 932920006406 active site 932920006407 FMN-binding site [chemical binding]; other site 932920006408 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 932920006409 active site 932920006410 multimer interface [polypeptide binding]; other site 932920006411 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 932920006412 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 932920006413 substrate binding pocket [chemical binding]; other site 932920006414 chain length determination region; other site 932920006415 substrate-Mg2+ binding site; other site 932920006416 catalytic residues [active] 932920006417 aspartate-rich region 1; other site 932920006418 active site lid residues [active] 932920006419 aspartate-rich region 2; other site 932920006420 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 932920006421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920006422 S-adenosylmethionine binding site [chemical binding]; other site 932920006423 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 932920006424 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 932920006425 homodecamer interface [polypeptide binding]; other site 932920006426 GTP cyclohydrolase I; Provisional; Region: PLN03044 932920006427 active site 932920006428 putative catalytic site residues [active] 932920006429 zinc binding site [ion binding]; other site 932920006430 GTP-CH-I/GFRP interaction surface; other site 932920006431 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 932920006432 IHF dimer interface [polypeptide binding]; other site 932920006433 IHF - DNA interface [nucleotide binding]; other site 932920006434 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 932920006435 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 932920006436 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 932920006437 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 932920006438 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 932920006439 GTP-binding protein Der; Reviewed; Region: PRK00093 932920006440 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 932920006441 G1 box; other site 932920006442 GTP/Mg2+ binding site [chemical binding]; other site 932920006443 Switch I region; other site 932920006444 G2 box; other site 932920006445 Switch II region; other site 932920006446 G3 box; other site 932920006447 G4 box; other site 932920006448 G5 box; other site 932920006449 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 932920006450 G1 box; other site 932920006451 GTP/Mg2+ binding site [chemical binding]; other site 932920006452 Switch I region; other site 932920006453 G2 box; other site 932920006454 G3 box; other site 932920006455 Switch II region; other site 932920006456 G4 box; other site 932920006457 G5 box; other site 932920006458 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 932920006459 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 932920006460 RNA binding site [nucleotide binding]; other site 932920006461 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 932920006462 RNA binding site [nucleotide binding]; other site 932920006463 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 932920006464 RNA binding site [nucleotide binding]; other site 932920006465 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 932920006466 RNA binding site [nucleotide binding]; other site 932920006467 cytidylate kinase; Provisional; Region: cmk; PRK00023 932920006468 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 932920006469 CMP-binding site; other site 932920006470 The sites determining sugar specificity; other site 932920006471 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 932920006472 active site 932920006473 homotetramer interface [polypeptide binding]; other site 932920006474 homodimer interface [polypeptide binding]; other site 932920006475 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932920006476 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 932920006477 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 932920006478 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932920006479 ATP binding site [chemical binding]; other site 932920006480 putative Mg++ binding site [ion binding]; other site 932920006481 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932920006482 nucleotide binding region [chemical binding]; other site 932920006483 ATP-binding site [chemical binding]; other site 932920006484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 932920006485 Predicted membrane protein [Function unknown]; Region: COG3601 932920006486 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 932920006487 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 932920006488 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932920006489 dimerization interface [polypeptide binding]; other site 932920006490 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 932920006491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932920006492 dimer interface [polypeptide binding]; other site 932920006493 phosphorylation site [posttranslational modification] 932920006494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920006495 ATP binding site [chemical binding]; other site 932920006496 Mg2+ binding site [ion binding]; other site 932920006497 G-X-G motif; other site 932920006498 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932920006499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920006500 active site 932920006501 phosphorylation site [posttranslational modification] 932920006502 intermolecular recognition site; other site 932920006503 dimerization interface [polypeptide binding]; other site 932920006504 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932920006505 DNA binding site [nucleotide binding] 932920006506 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 932920006507 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932920006508 RNA binding surface [nucleotide binding]; other site 932920006509 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 932920006510 active site 932920006511 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 932920006512 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 932920006513 diaminopimelate decarboxylase; Region: lysA; TIGR01048 932920006514 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 932920006515 active site 932920006516 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 932920006517 substrate binding site [chemical binding]; other site 932920006518 catalytic residues [active] 932920006519 dimer interface [polypeptide binding]; other site 932920006520 purine nucleoside phosphorylase; Provisional; Region: PRK08202 932920006521 phosphopentomutase; Provisional; Region: PRK05362 932920006522 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 932920006523 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 932920006524 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 932920006525 active site 932920006526 Int/Topo IB signature motif; other site 932920006527 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 932920006528 metal binding site 2 [ion binding]; metal-binding site 932920006529 putative DNA binding helix; other site 932920006530 metal binding site 1 [ion binding]; metal-binding site 932920006531 dimer interface [polypeptide binding]; other site 932920006532 structural Zn2+ binding site [ion binding]; other site 932920006533 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 932920006534 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932920006535 ABC-ATPase subunit interface; other site 932920006536 dimer interface [polypeptide binding]; other site 932920006537 putative PBP binding regions; other site 932920006538 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 932920006539 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932920006540 ABC-ATPase subunit interface; other site 932920006541 dimer interface [polypeptide binding]; other site 932920006542 putative PBP binding regions; other site 932920006543 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 932920006544 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 932920006545 putative ligand binding residues [chemical binding]; other site 932920006546 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 932920006547 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 932920006548 Walker A/P-loop; other site 932920006549 ATP binding site [chemical binding]; other site 932920006550 Q-loop/lid; other site 932920006551 ABC transporter signature motif; other site 932920006552 Walker B; other site 932920006553 D-loop; other site 932920006554 H-loop/switch region; other site 932920006555 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 932920006556 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932920006557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932920006558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932920006559 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 932920006560 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 932920006561 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 932920006562 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 932920006563 Walker A/P-loop; other site 932920006564 ATP binding site [chemical binding]; other site 932920006565 Q-loop/lid; other site 932920006566 ABC transporter signature motif; other site 932920006567 Walker B; other site 932920006568 D-loop; other site 932920006569 H-loop/switch region; other site 932920006570 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 932920006571 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 932920006572 dimer interface [polypeptide binding]; other site 932920006573 ADP-ribose binding site [chemical binding]; other site 932920006574 active site 932920006575 nudix motif; other site 932920006576 metal binding site [ion binding]; metal-binding site 932920006577 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 932920006578 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 932920006579 Creatinine amidohydrolase; Region: Creatininase; pfam02633 932920006580 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 932920006581 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 932920006582 active site 932920006583 intersubunit interface [polypeptide binding]; other site 932920006584 catalytic residue [active] 932920006585 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 932920006586 active site 932920006587 substrate binding pocket [chemical binding]; other site 932920006588 homodimer interaction site [polypeptide binding]; other site 932920006589 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 932920006590 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 932920006591 active site 932920006592 P-loop; other site 932920006593 phosphorylation site [posttranslational modification] 932920006594 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920006595 active site 932920006596 phosphorylation site [posttranslational modification] 932920006597 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932920006598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920006599 DNA-binding site [nucleotide binding]; DNA binding site 932920006600 UTRA domain; Region: UTRA; pfam07702 932920006601 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 932920006602 active site 932920006603 DNA polymerase IV; Validated; Region: PRK02406 932920006604 DNA binding site [nucleotide binding] 932920006605 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 932920006606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932920006607 NAD(P) binding site [chemical binding]; other site 932920006608 active site 932920006609 ribonuclease Z; Region: RNase_Z; TIGR02651 932920006610 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 932920006611 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 932920006612 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 932920006613 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 932920006614 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932920006615 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932920006616 Coenzyme A binding pocket [chemical binding]; other site 932920006617 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 932920006618 6-phosphogluconate dehydratase; Region: edd; TIGR01196 932920006619 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 932920006620 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 932920006621 PYR/PP interface [polypeptide binding]; other site 932920006622 dimer interface [polypeptide binding]; other site 932920006623 TPP binding site [chemical binding]; other site 932920006624 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 932920006625 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 932920006626 TPP-binding site [chemical binding]; other site 932920006627 dimer interface [polypeptide binding]; other site 932920006628 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 932920006629 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 932920006630 putative valine binding site [chemical binding]; other site 932920006631 dimer interface [polypeptide binding]; other site 932920006632 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 932920006633 ketol-acid reductoisomerase; Provisional; Region: PRK05479 932920006634 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 932920006635 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 932920006636 2-isopropylmalate synthase; Validated; Region: PRK00915 932920006637 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 932920006638 active site 932920006639 catalytic residues [active] 932920006640 metal binding site [ion binding]; metal-binding site 932920006641 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 932920006642 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 932920006643 tartrate dehydrogenase; Region: TTC; TIGR02089 932920006644 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 932920006645 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 932920006646 substrate binding site [chemical binding]; other site 932920006647 ligand binding site [chemical binding]; other site 932920006648 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 932920006649 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 932920006650 substrate binding site [chemical binding]; other site 932920006651 threonine dehydratase; Validated; Region: PRK08639 932920006652 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 932920006653 tetramer interface [polypeptide binding]; other site 932920006654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920006655 catalytic residue [active] 932920006656 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 932920006657 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 932920006658 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 932920006659 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 932920006660 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 932920006661 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 932920006662 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932920006663 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932920006664 DNA binding site [nucleotide binding] 932920006665 domain linker motif; other site 932920006666 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 932920006667 dimerization interface [polypeptide binding]; other site 932920006668 ligand binding site [chemical binding]; other site 932920006669 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 932920006670 intersubunit interface [polypeptide binding]; other site 932920006671 active site 932920006672 catalytic residue [active] 932920006673 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 932920006674 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 932920006675 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 932920006676 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 932920006677 active pocket/dimerization site; other site 932920006678 active site 932920006679 phosphorylation site [posttranslational modification] 932920006680 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 932920006681 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 932920006682 putative active site [active] 932920006683 SIS domain; Region: SIS; pfam01380 932920006684 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 932920006685 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 932920006686 dimer interface [polypeptide binding]; other site 932920006687 active site 932920006688 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 932920006689 dimer interface [polypeptide binding]; other site 932920006690 active site 932920006691 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 932920006692 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 932920006693 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 932920006694 active site 932920006695 phosphorylation site [posttranslational modification] 932920006696 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932920006697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920006698 DNA-binding site [nucleotide binding]; DNA binding site 932920006699 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 932920006700 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932920006701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920006702 DNA-binding site [nucleotide binding]; DNA binding site 932920006703 UTRA domain; Region: UTRA; pfam07702 932920006704 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932920006705 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932920006706 active site 932920006707 catalytic tetrad [active] 932920006708 acetolactate synthase; Reviewed; Region: PRK08617 932920006709 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 932920006710 PYR/PP interface [polypeptide binding]; other site 932920006711 dimer interface [polypeptide binding]; other site 932920006712 TPP binding site [chemical binding]; other site 932920006713 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 932920006714 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 932920006715 TPP-binding site [chemical binding]; other site 932920006716 dimer interface [polypeptide binding]; other site 932920006717 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932920006718 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 932920006719 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 932920006720 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932920006721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920006722 dimer interface [polypeptide binding]; other site 932920006723 conserved gate region; other site 932920006724 ABC-ATPase subunit interface; other site 932920006725 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 932920006726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920006727 dimer interface [polypeptide binding]; other site 932920006728 conserved gate region; other site 932920006729 ABC-ATPase subunit interface; other site 932920006730 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 932920006731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920006732 active site 932920006733 phosphorylation site [posttranslational modification] 932920006734 intermolecular recognition site; other site 932920006735 dimerization interface [polypeptide binding]; other site 932920006736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932920006737 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 932920006738 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932920006739 dimerization interface [polypeptide binding]; other site 932920006740 Histidine kinase; Region: His_kinase; pfam06580 932920006741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920006742 ATP binding site [chemical binding]; other site 932920006743 Mg2+ binding site [ion binding]; other site 932920006744 G-X-G motif; other site 932920006745 Predicted integral membrane protein [Function unknown]; Region: COG5578 932920006746 Uncharacterized conserved protein [Function unknown]; Region: COG3538 932920006747 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 932920006748 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 932920006749 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 932920006750 active site 932920006751 metal binding site [ion binding]; metal-binding site 932920006752 homodimer interface [polypeptide binding]; other site 932920006753 catalytic site [active] 932920006754 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 932920006755 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 932920006756 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 932920006757 active site 932920006758 catalytic site [active] 932920006759 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 932920006760 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 932920006761 DNA-binding site [nucleotide binding]; DNA binding site 932920006762 RNA-binding motif; other site 932920006763 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 932920006764 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 932920006765 active site 932920006766 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 932920006767 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 932920006768 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 932920006769 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 932920006770 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 932920006771 HIGH motif; other site 932920006772 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 932920006773 active site 932920006774 KMSKS motif; other site 932920006775 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 932920006776 tRNA binding surface [nucleotide binding]; other site 932920006777 anticodon binding site; other site 932920006778 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 932920006779 DivIVA protein; Region: DivIVA; pfam05103 932920006780 DivIVA domain; Region: DivI1A_domain; TIGR03544 932920006781 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 932920006782 HTH domain; Region: HTH_11; pfam08279 932920006783 3H domain; Region: 3H; pfam02829 932920006784 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 932920006785 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 932920006786 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932920006787 catalytic residue [active] 932920006788 L-aspartate oxidase; Provisional; Region: PRK08071 932920006789 L-aspartate oxidase; Provisional; Region: PRK06175 932920006790 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 932920006791 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 932920006792 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 932920006793 dimerization interface [polypeptide binding]; other site 932920006794 active site 932920006795 quinolinate synthetase; Provisional; Region: PRK09375 932920006796 Leucine rich repeat; Region: LRR_8; pfam13855 932920006797 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920006798 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920006799 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932920006800 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932920006801 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920006802 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 932920006803 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932920006804 RNA binding surface [nucleotide binding]; other site 932920006805 YGGT family; Region: YGGT; pfam02325 932920006806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 932920006807 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 932920006808 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 932920006809 catalytic residue [active] 932920006810 cell division protein FtsZ; Validated; Region: PRK09330 932920006811 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 932920006812 nucleotide binding site [chemical binding]; other site 932920006813 SulA interaction site; other site 932920006814 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 932920006815 Cell division protein FtsA; Region: FtsA; smart00842 932920006816 Cell division protein FtsA; Region: FtsA; pfam14450 932920006817 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 932920006818 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 932920006819 Cell division protein FtsQ; Region: FtsQ; pfam03799 932920006820 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 932920006821 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 932920006822 active site 932920006823 homodimer interface [polypeptide binding]; other site 932920006824 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 932920006825 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932920006826 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 932920006827 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 932920006828 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 932920006829 Mg++ binding site [ion binding]; other site 932920006830 putative catalytic motif [active] 932920006831 putative substrate binding site [chemical binding]; other site 932920006832 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 932920006833 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 932920006834 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932920006835 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 932920006836 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 932920006837 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 932920006838 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 932920006839 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 932920006840 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 932920006841 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 932920006842 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 932920006843 MraW methylase family; Region: Methyltransf_5; pfam01795 932920006844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 932920006845 MraZ protein; Region: MraZ; pfam02381 932920006846 MraZ protein; Region: MraZ; pfam02381 932920006847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920006848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920006849 putative substrate translocation pore; other site 932920006850 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 932920006851 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 932920006852 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 932920006853 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 932920006854 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 932920006855 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 932920006856 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 932920006857 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 932920006858 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 932920006859 hypothetical protein; Provisional; Region: PRK13670 932920006860 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 932920006861 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 932920006862 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 932920006863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920006864 Walker A/P-loop; other site 932920006865 ATP binding site [chemical binding]; other site 932920006866 Q-loop/lid; other site 932920006867 ABC transporter signature motif; other site 932920006868 Walker B; other site 932920006869 D-loop; other site 932920006870 H-loop/switch region; other site 932920006871 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 932920006872 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 932920006873 protein binding site [polypeptide binding]; other site 932920006874 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 932920006875 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 932920006876 active site 932920006877 (T/H)XGH motif; other site 932920006878 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 932920006879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920006880 S-adenosylmethionine binding site [chemical binding]; other site 932920006881 hypothetical protein; Provisional; Region: PRK02886 932920006882 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 932920006883 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 932920006884 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 932920006885 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 932920006886 UbiA prenyltransferase family; Region: UbiA; pfam01040 932920006887 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 932920006888 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 932920006889 Ion transport protein; Region: Ion_trans; pfam00520 932920006890 Ion channel; Region: Ion_trans_2; pfam07885 932920006891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 932920006892 MOSC domain; Region: MOSC; pfam03473 932920006893 3-alpha domain; Region: 3-alpha; pfam03475 932920006894 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 932920006895 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 932920006896 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 932920006897 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 932920006898 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 932920006899 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 932920006900 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 932920006901 active site 932920006902 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 932920006903 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 932920006904 ring oligomerisation interface [polypeptide binding]; other site 932920006905 ATP/Mg binding site [chemical binding]; other site 932920006906 stacking interactions; other site 932920006907 hinge regions; other site 932920006908 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 932920006909 oligomerisation interface [polypeptide binding]; other site 932920006910 mobile loop; other site 932920006911 roof hairpin; other site 932920006912 CAAX protease self-immunity; Region: Abi; pfam02517 932920006913 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 932920006914 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 932920006915 CoA binding domain; Region: CoA_binding; pfam02629 932920006916 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 932920006917 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932920006918 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932920006919 ABC transporter; Region: ABC_tran_2; pfam12848 932920006920 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932920006921 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 932920006922 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 932920006923 UGMP family protein; Validated; Region: PRK09604 932920006924 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 932920006925 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 932920006926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920006927 Coenzyme A binding pocket [chemical binding]; other site 932920006928 Glycoprotease family; Region: Peptidase_M22; pfam00814 932920006929 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 932920006930 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 932920006931 camphor resistance protein CrcB; Provisional; Region: PRK14214 932920006932 camphor resistance protein CrcB; Provisional; Region: PRK14231 932920006933 Uncharacterized conserved protein [Function unknown]; Region: COG4832 932920006934 Phosphotransferase enzyme family; Region: APH; pfam01636 932920006935 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 932920006936 active site 932920006937 substrate binding site [chemical binding]; other site 932920006938 ATP binding site [chemical binding]; other site 932920006939 Cna protein B-type domain; Region: Cna_B; pfam05738 932920006940 Cna protein B-type domain; Region: Cna_B; pfam05738 932920006941 Cna protein B-type domain; Region: Cna_B; pfam05738 932920006942 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932920006943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920006944 non-specific DNA binding site [nucleotide binding]; other site 932920006945 salt bridge; other site 932920006946 sequence-specific DNA binding site [nucleotide binding]; other site 932920006947 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 932920006948 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 932920006949 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932920006950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932920006951 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 932920006952 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 932920006953 substrate binding pocket [chemical binding]; other site 932920006954 argininosuccinate synthase; Provisional; Region: PRK13820 932920006955 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 932920006956 ANP binding site [chemical binding]; other site 932920006957 Substrate Binding Site II [chemical binding]; other site 932920006958 Substrate Binding Site I [chemical binding]; other site 932920006959 argininosuccinate lyase; Provisional; Region: PRK00855 932920006960 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 932920006961 active sites [active] 932920006962 tetramer interface [polypeptide binding]; other site 932920006963 BCCT family transporter; Region: BCCT; pfam02028 932920006964 hypothetical protein; Provisional; Region: PRK06357 932920006965 active site 932920006966 intersubunit interface [polypeptide binding]; other site 932920006967 Zn2+ binding site [ion binding]; other site 932920006968 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 932920006969 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 932920006970 putative substrate binding site [chemical binding]; other site 932920006971 putative ATP binding site [chemical binding]; other site 932920006972 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 932920006973 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 932920006974 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 932920006975 active site 932920006976 P-loop; other site 932920006977 phosphorylation site [posttranslational modification] 932920006978 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920006979 active site 932920006980 phosphorylation site [posttranslational modification] 932920006981 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932920006982 PRD domain; Region: PRD; pfam00874 932920006983 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932920006984 active site 932920006985 P-loop; other site 932920006986 phosphorylation site [posttranslational modification] 932920006987 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 932920006988 active site 932920006989 phosphorylation site [posttranslational modification] 932920006990 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 932920006991 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920006992 DNA-binding site [nucleotide binding]; DNA binding site 932920006993 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932920006994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920006995 homodimer interface [polypeptide binding]; other site 932920006996 catalytic residue [active] 932920006997 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 932920006998 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 932920006999 active site 932920007000 multimer interface [polypeptide binding]; other site 932920007001 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 932920007002 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 932920007003 predicted active site [active] 932920007004 catalytic triad [active] 932920007005 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 932920007006 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 932920007007 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 932920007008 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 932920007009 G1 box; other site 932920007010 GTP/Mg2+ binding site [chemical binding]; other site 932920007011 Switch I region; other site 932920007012 G2 box; other site 932920007013 G3 box; other site 932920007014 Switch II region; other site 932920007015 G4 box; other site 932920007016 G5 box; other site 932920007017 Nucleoside recognition; Region: Gate; pfam07670 932920007018 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 932920007019 Nucleoside recognition; Region: Gate; pfam07670 932920007020 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 932920007021 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 932920007022 putative active site [active] 932920007023 putative metal binding site [ion binding]; other site 932920007024 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932920007025 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 932920007026 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932920007027 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 932920007028 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 932920007029 active site 932920007030 dimer interface [polypeptide binding]; other site 932920007031 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 932920007032 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 932920007033 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 932920007034 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 932920007035 dimer interface [polypeptide binding]; other site 932920007036 FMN binding site [chemical binding]; other site 932920007037 NADPH bind site [chemical binding]; other site 932920007038 Helix-turn-helix domain; Region: HTH_17; pfam12728 932920007039 putative heme peroxidase; Provisional; Region: PRK12276 932920007040 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932920007041 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932920007042 Walker A/P-loop; other site 932920007043 ATP binding site [chemical binding]; other site 932920007044 Q-loop/lid; other site 932920007045 ABC transporter signature motif; other site 932920007046 Walker B; other site 932920007047 D-loop; other site 932920007048 H-loop/switch region; other site 932920007049 FtsX-like permease family; Region: FtsX; pfam02687 932920007050 FtsX-like permease family; Region: FtsX; pfam02687 932920007051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920007052 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932920007053 Coenzyme A binding pocket [chemical binding]; other site 932920007054 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 932920007055 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 932920007056 active site 932920007057 substrate binding site [chemical binding]; other site 932920007058 metal binding site [ion binding]; metal-binding site 932920007059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 932920007060 YbbR-like protein; Region: YbbR; pfam07949 932920007061 YbbR-like protein; Region: YbbR; pfam07949 932920007062 YbbR-like protein; Region: YbbR; pfam07949 932920007063 Uncharacterized conserved protein [Function unknown]; Region: COG1624 932920007064 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 932920007065 maltose phosphorylase; Provisional; Region: PRK13807 932920007066 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 932920007067 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 932920007068 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 932920007069 Predicted integral membrane protein [Function unknown]; Region: COG5521 932920007070 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932920007071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920007072 dimer interface [polypeptide binding]; other site 932920007073 conserved gate region; other site 932920007074 putative PBP binding loops; other site 932920007075 ABC-ATPase subunit interface; other site 932920007076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920007077 dimer interface [polypeptide binding]; other site 932920007078 conserved gate region; other site 932920007079 putative PBP binding loops; other site 932920007080 ABC-ATPase subunit interface; other site 932920007081 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 932920007082 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932920007083 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 932920007084 homodimer interface [polypeptide binding]; other site 932920007085 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 932920007086 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 932920007087 active site 932920007088 homodimer interface [polypeptide binding]; other site 932920007089 catalytic site [active] 932920007090 CAAX protease self-immunity; Region: Abi; cl00558 932920007091 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932920007092 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932920007093 DNA binding site [nucleotide binding] 932920007094 domain linker motif; other site 932920007095 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 932920007096 ligand binding site [chemical binding]; other site 932920007097 dimerization interface [polypeptide binding]; other site 932920007098 Amino acid permease; Region: AA_permease_2; pfam13520 932920007099 K+ potassium transporter; Region: K_trans; cl15781 932920007100 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920007101 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932920007102 ligand binding site [chemical binding]; other site 932920007103 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920007104 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 932920007105 ligand binding site [chemical binding]; other site 932920007106 flexible hinge region; other site 932920007107 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 932920007108 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 932920007109 intersubunit interface [polypeptide binding]; other site 932920007110 active site 932920007111 zinc binding site [ion binding]; other site 932920007112 Na+ binding site [ion binding]; other site 932920007113 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 932920007114 intersubunit interface [polypeptide binding]; other site 932920007115 active site 932920007116 zinc binding site [ion binding]; other site 932920007117 Na+ binding site [ion binding]; other site 932920007118 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 932920007119 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932920007120 active site 932920007121 P-loop; other site 932920007122 phosphorylation site [posttranslational modification] 932920007123 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920007124 active site 932920007125 phosphorylation site [posttranslational modification] 932920007126 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932920007127 HTH domain; Region: HTH_11; pfam08279 932920007128 Mga helix-turn-helix domain; Region: Mga; pfam05043 932920007129 PRD domain; Region: PRD; pfam00874 932920007130 PRD domain; Region: PRD; pfam00874 932920007131 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932920007132 active site 932920007133 P-loop; other site 932920007134 phosphorylation site [posttranslational modification] 932920007135 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 932920007136 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920007137 Walker A/P-loop; other site 932920007138 ATP binding site [chemical binding]; other site 932920007139 Q-loop/lid; other site 932920007140 ABC transporter signature motif; other site 932920007141 Walker B; other site 932920007142 D-loop; other site 932920007143 H-loop/switch region; other site 932920007144 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 932920007145 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 932920007146 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932920007147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920007148 Coenzyme A binding pocket [chemical binding]; other site 932920007149 Transcriptional regulators [Transcription]; Region: GntR; COG1802 932920007150 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 932920007151 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 932920007152 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932920007153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920007154 DNA-binding site [nucleotide binding]; DNA binding site 932920007155 UTRA domain; Region: UTRA; pfam07702 932920007156 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 932920007157 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 932920007158 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932920007159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932920007160 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 932920007161 putative dimerization interface [polypeptide binding]; other site 932920007162 Predicted membrane protein [Function unknown]; Region: COG2855 932920007163 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 932920007164 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 932920007165 putative metal binding site [ion binding]; other site 932920007166 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 932920007167 homodimer interface [polypeptide binding]; other site 932920007168 chemical substrate binding site [chemical binding]; other site 932920007169 oligomer interface [polypeptide binding]; other site 932920007170 metal binding site [ion binding]; metal-binding site 932920007171 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 932920007172 catalytic residues [active] 932920007173 flavodoxin; Provisional; Region: PRK09271 932920007174 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 932920007175 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 932920007176 dimer interface [polypeptide binding]; other site 932920007177 putative radical transfer pathway; other site 932920007178 diiron center [ion binding]; other site 932920007179 tyrosyl radical; other site 932920007180 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 932920007181 Class I ribonucleotide reductase; Region: RNR_I; cd01679 932920007182 active site 932920007183 dimer interface [polypeptide binding]; other site 932920007184 catalytic residues [active] 932920007185 effector binding site; other site 932920007186 R2 peptide binding site; other site 932920007187 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 932920007188 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 932920007189 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 932920007190 CsbD-like; Region: CsbD; cl17424 932920007191 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932920007192 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932920007193 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932920007194 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 932920007195 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 932920007196 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 932920007197 conserved cys residue [active] 932920007198 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 932920007199 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932920007200 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932920007201 Cupin domain; Region: Cupin_2; cl17218 932920007202 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932920007203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932920007204 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920007205 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 932920007206 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920007207 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932920007208 ligand binding site [chemical binding]; other site 932920007209 flexible hinge region; other site 932920007210 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 932920007211 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932920007212 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932920007213 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 932920007214 dimer interface [polypeptide binding]; other site 932920007215 active site 932920007216 metal binding site [ion binding]; metal-binding site 932920007217 glutathione binding site [chemical binding]; other site 932920007218 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 932920007219 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 932920007220 FMN binding site [chemical binding]; other site 932920007221 substrate binding site [chemical binding]; other site 932920007222 putative catalytic residue [active] 932920007223 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 932920007224 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 932920007225 Coenzyme A transferase; Region: CoA_trans; smart00882 932920007226 Coenzyme A transferase; Region: CoA_trans; cl17247 932920007227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920007228 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 932920007229 Walker A motif; other site 932920007230 ATP binding site [chemical binding]; other site 932920007231 Walker B motif; other site 932920007232 arginine finger; other site 932920007233 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 932920007234 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 932920007235 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932920007236 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932920007237 metal binding site [ion binding]; metal-binding site 932920007238 active site 932920007239 I-site; other site 932920007240 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 932920007241 classical (c) SDRs; Region: SDR_c; cd05233 932920007242 NAD(P) binding site [chemical binding]; other site 932920007243 active site 932920007244 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932920007245 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932920007246 Tic20-like protein; Region: Tic20; pfam09685 932920007247 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 932920007248 Cna protein B-type domain; Region: Cna_B; pfam05738 932920007249 Collagen binding domain; Region: Collagen_bind; pfam05737 932920007250 Cna protein B-type domain; Region: Cna_B; pfam05738 932920007251 Cna protein B-type domain; Region: Cna_B; pfam05738 932920007252 Cna protein B-type domain; Region: Cna_B; pfam05738 932920007253 Cna protein B-type domain; Region: Cna_B; pfam05738 932920007254 Cna protein B-type domain; Region: Cna_B; pfam05738 932920007255 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920007256 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920007257 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920007258 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 932920007259 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 932920007260 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 932920007261 active site 932920007262 catalytic site [active] 932920007263 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 932920007264 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 932920007265 Walker A/P-loop; other site 932920007266 ATP binding site [chemical binding]; other site 932920007267 Q-loop/lid; other site 932920007268 ABC transporter signature motif; other site 932920007269 Walker B; other site 932920007270 D-loop; other site 932920007271 H-loop/switch region; other site 932920007272 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 932920007273 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932920007274 ABC-ATPase subunit interface; other site 932920007275 dimer interface [polypeptide binding]; other site 932920007276 putative PBP binding regions; other site 932920007277 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 932920007278 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 932920007279 putative ligand binding residues [chemical binding]; other site 932920007280 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 932920007281 heme-binding site [chemical binding]; other site 932920007282 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 932920007283 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 932920007284 heme-binding site [chemical binding]; other site 932920007285 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 932920007286 heme-binding site [chemical binding]; other site 932920007287 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 932920007288 heme uptake protein IsdC; Region: IsdC; TIGR03656 932920007289 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 932920007290 heme-binding site [chemical binding]; other site 932920007291 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 932920007292 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 932920007293 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 932920007294 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 932920007295 active site 932920007296 Zn binding site [ion binding]; other site 932920007297 Competence protein CoiA-like family; Region: CoiA; cl11541 932920007298 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 932920007299 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 932920007300 ArsC family; Region: ArsC; pfam03960 932920007301 putative catalytic residues [active] 932920007302 thiol/disulfide switch; other site 932920007303 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 932920007304 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932920007305 Walker A/P-loop; other site 932920007306 ATP binding site [chemical binding]; other site 932920007307 Q-loop/lid; other site 932920007308 ABC transporter signature motif; other site 932920007309 Walker B; other site 932920007310 D-loop; other site 932920007311 H-loop/switch region; other site 932920007312 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 932920007313 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 932920007314 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932920007315 Walker A/P-loop; other site 932920007316 ATP binding site [chemical binding]; other site 932920007317 Q-loop/lid; other site 932920007318 ABC transporter signature motif; other site 932920007319 Walker B; other site 932920007320 D-loop; other site 932920007321 H-loop/switch region; other site 932920007322 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 932920007323 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 932920007324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920007325 dimer interface [polypeptide binding]; other site 932920007326 conserved gate region; other site 932920007327 putative PBP binding loops; other site 932920007328 ABC-ATPase subunit interface; other site 932920007329 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 932920007330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920007331 dimer interface [polypeptide binding]; other site 932920007332 conserved gate region; other site 932920007333 putative PBP binding loops; other site 932920007334 ABC-ATPase subunit interface; other site 932920007335 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 932920007336 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 932920007337 peptide binding site [polypeptide binding]; other site 932920007338 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 932920007339 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 932920007340 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 932920007341 active site 932920007342 HIGH motif; other site 932920007343 dimer interface [polypeptide binding]; other site 932920007344 KMSKS motif; other site 932920007345 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 932920007346 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932920007347 MarR family; Region: MarR; pfam01047 932920007348 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 932920007349 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 932920007350 dimer interface [polypeptide binding]; other site 932920007351 active site 932920007352 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 932920007353 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 932920007354 dimer interface [polypeptide binding]; other site 932920007355 active site 932920007356 CoA binding pocket [chemical binding]; other site 932920007357 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 932920007358 SH3-like domain; Region: SH3_8; pfam13457 932920007359 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 932920007360 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932920007361 catalytic core [active] 932920007362 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932920007363 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 932920007364 Clp amino terminal domain; Region: Clp_N; pfam02861 932920007365 Clp amino terminal domain; Region: Clp_N; pfam02861 932920007366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920007367 Walker A motif; other site 932920007368 ATP binding site [chemical binding]; other site 932920007369 Walker B motif; other site 932920007370 arginine finger; other site 932920007371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920007372 Walker A motif; other site 932920007373 ATP binding site [chemical binding]; other site 932920007374 Walker B motif; other site 932920007375 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 932920007376 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 932920007377 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 932920007378 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932920007379 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920007380 active site 932920007381 motif I; other site 932920007382 motif II; other site 932920007383 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 932920007384 Predicted acetyltransferase [General function prediction only]; Region: COG3393 932920007385 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 932920007386 ferrochelatase; Provisional; Region: PRK12435 932920007387 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 932920007388 C-terminal domain interface [polypeptide binding]; other site 932920007389 active site 932920007390 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 932920007391 active site 932920007392 N-terminal domain interface [polypeptide binding]; other site 932920007393 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 932920007394 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 932920007395 substrate binding site [chemical binding]; other site 932920007396 active site 932920007397 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 932920007398 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 932920007399 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 932920007400 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 932920007401 Walker A/P-loop; other site 932920007402 ATP binding site [chemical binding]; other site 932920007403 Q-loop/lid; other site 932920007404 ABC transporter signature motif; other site 932920007405 Walker B; other site 932920007406 D-loop; other site 932920007407 H-loop/switch region; other site 932920007408 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 932920007409 HIT family signature motif; other site 932920007410 catalytic residue [active] 932920007411 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 932920007412 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 932920007413 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 932920007414 SurA N-terminal domain; Region: SurA_N_3; cl07813 932920007415 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 932920007416 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 932920007417 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 932920007418 generic binding surface II; other site 932920007419 generic binding surface I; other site 932920007420 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932920007421 Zn2+ binding site [ion binding]; other site 932920007422 Mg2+ binding site [ion binding]; other site 932920007423 Uncharacterized conserved protein [Function unknown]; Region: COG4717 932920007424 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 932920007425 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 932920007426 active site 932920007427 metal binding site [ion binding]; metal-binding site 932920007428 DNA binding site [nucleotide binding] 932920007429 hypothetical protein; Provisional; Region: PRK13676 932920007430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 932920007431 fumarate hydratase; Reviewed; Region: fumC; PRK00485 932920007432 Class II fumarases; Region: Fumarase_classII; cd01362 932920007433 active site 932920007434 tetramer interface [polypeptide binding]; other site 932920007435 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 932920007436 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 932920007437 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 932920007438 Walker A/P-loop; other site 932920007439 ATP binding site [chemical binding]; other site 932920007440 Q-loop/lid; other site 932920007441 ABC transporter signature motif; other site 932920007442 Walker B; other site 932920007443 D-loop; other site 932920007444 H-loop/switch region; other site 932920007445 Transglycosylase; Region: Transgly; pfam00912 932920007446 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 932920007447 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 932920007448 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 932920007449 Low molecular weight phosphatase family; Region: LMWPc; cl00105 932920007450 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 932920007451 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 932920007452 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 932920007453 Domain of unknown function DUF21; Region: DUF21; pfam01595 932920007454 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 932920007455 Transporter associated domain; Region: CorC_HlyC; smart01091 932920007456 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932920007457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932920007458 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 932920007459 putative dimerization interface [polypeptide binding]; other site 932920007460 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 932920007461 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 932920007462 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 932920007463 active site 932920007464 FMN binding site [chemical binding]; other site 932920007465 substrate binding site [chemical binding]; other site 932920007466 putative catalytic residue [active] 932920007467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932920007468 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932920007469 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 932920007470 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 932920007471 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 932920007472 shikimate binding site; other site 932920007473 NAD(P) binding site [chemical binding]; other site 932920007474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920007475 putative substrate translocation pore; other site 932920007476 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920007477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920007478 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920007479 putative substrate translocation pore; other site 932920007480 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 932920007481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920007482 Walker A/P-loop; other site 932920007483 ATP binding site [chemical binding]; other site 932920007484 Q-loop/lid; other site 932920007485 ABC transporter signature motif; other site 932920007486 Walker B; other site 932920007487 D-loop; other site 932920007488 H-loop/switch region; other site 932920007489 Predicted transcriptional regulators [Transcription]; Region: COG1725 932920007490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932920007491 DNA-binding site [nucleotide binding]; DNA binding site 932920007492 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 932920007493 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 932920007494 DNA binding site [nucleotide binding] 932920007495 active site 932920007496 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 932920007497 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 932920007498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932920007499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932920007500 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 932920007501 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 932920007502 active site 932920007503 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 932920007504 putative dimer interface [polypeptide binding]; other site 932920007505 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932920007506 ligand binding site [chemical binding]; other site 932920007507 Zn binding site [ion binding]; other site 932920007508 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 932920007509 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 932920007510 active site 932920007511 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932920007512 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932920007513 active site 932920007514 catalytic tetrad [active] 932920007515 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 932920007516 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 932920007517 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932920007518 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932920007519 substrate binding pocket [chemical binding]; other site 932920007520 membrane-bound complex binding site; other site 932920007521 hinge residues; other site 932920007522 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932920007523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920007524 dimer interface [polypeptide binding]; other site 932920007525 conserved gate region; other site 932920007526 putative PBP binding loops; other site 932920007527 ABC-ATPase subunit interface; other site 932920007528 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 932920007529 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 932920007530 Walker A/P-loop; other site 932920007531 ATP binding site [chemical binding]; other site 932920007532 Q-loop/lid; other site 932920007533 ABC transporter signature motif; other site 932920007534 Walker B; other site 932920007535 D-loop; other site 932920007536 H-loop/switch region; other site 932920007537 aspartate aminotransferase; Provisional; Region: PRK06348 932920007538 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932920007539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920007540 homodimer interface [polypeptide binding]; other site 932920007541 catalytic residue [active] 932920007542 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 932920007543 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 932920007544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920007545 motif II; other site 932920007546 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 932920007547 intracellular protease, PfpI family; Region: PfpI; TIGR01382 932920007548 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 932920007549 proposed catalytic triad [active] 932920007550 conserved cys residue [active] 932920007551 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 932920007552 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932920007553 methionine cluster; other site 932920007554 active site 932920007555 phosphorylation site [posttranslational modification] 932920007556 metal binding site [ion binding]; metal-binding site 932920007557 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 932920007558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920007559 Coenzyme A binding pocket [chemical binding]; other site 932920007560 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 932920007561 esterase; Provisional; Region: PRK10566 932920007562 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 932920007563 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932920007564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 932920007565 motif II; other site 932920007566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920007567 Uncharacterized conserved protein [Function unknown]; Region: COG1284 932920007568 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 932920007569 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 932920007570 hypothetical protein; Provisional; Region: PRK13673 932920007571 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 932920007572 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 932920007573 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 932920007574 Part of AAA domain; Region: AAA_19; pfam13245 932920007575 Family description; Region: UvrD_C_2; pfam13538 932920007576 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 932920007577 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 932920007578 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 932920007579 IDEAL domain; Region: IDEAL; pfam08858 932920007580 ComK protein; Region: ComK; cl11560 932920007581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 932920007582 AP2 domain; Region: AP2; pfam00847 932920007583 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 932920007584 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 932920007585 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 932920007586 Bacteriophage holin; Region: Phage_holin_1; pfam04531 932920007587 putative oligopeptide transporter, OPT family; Region: TIGR00733 932920007588 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 932920007589 Phage tail protein; Region: Sipho_tail; cl17486 932920007590 Phage-related tail protein [Function unknown]; Region: COG5283 932920007591 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 932920007592 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 932920007593 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 932920007594 Phage terminase large subunit; Region: Terminase_3; cl12054 932920007595 Terminase-like family; Region: Terminase_6; pfam03237 932920007596 Terminase small subunit; Region: Terminase_2; cl01513 932920007597 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 932920007598 Recombination protein U; Region: RecU; cl01314 932920007599 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 932920007600 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 932920007601 dimer interface [polypeptide binding]; other site 932920007602 ssDNA binding site [nucleotide binding]; other site 932920007603 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932920007604 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 932920007605 Methyltransferase domain; Region: Methyltransf_25; pfam13649 932920007606 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 932920007607 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 932920007608 ERF superfamily; Region: ERF; pfam04404 932920007609 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 932920007610 Protein gp45 of Bacteriophage A118; Region: Phage-A118_gp45; pfam10653 932920007611 AntA/AntB antirepressor; Region: AntA; pfam08346 932920007612 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 932920007613 KTSC domain; Region: KTSC; pfam13619 932920007614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920007615 non-specific DNA binding site [nucleotide binding]; other site 932920007616 salt bridge; other site 932920007617 sequence-specific DNA binding site [nucleotide binding]; other site 932920007618 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932920007619 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920007620 sequence-specific DNA binding site [nucleotide binding]; other site 932920007621 salt bridge; other site 932920007622 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 932920007623 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 932920007624 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 932920007625 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 932920007626 catalytic residues [active] 932920007627 catalytic nucleophile [active] 932920007628 Presynaptic Site I dimer interface [polypeptide binding]; other site 932920007629 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 932920007630 Synaptic Flat tetramer interface [polypeptide binding]; other site 932920007631 Synaptic Site I dimer interface [polypeptide binding]; other site 932920007632 DNA binding site [nucleotide binding] 932920007633 Recombinase; Region: Recombinase; pfam07508 932920007634 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 932920007635 ComK protein; Region: ComK; cl11560 932920007636 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932920007637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920007638 non-specific DNA binding site [nucleotide binding]; other site 932920007639 salt bridge; other site 932920007640 sequence-specific DNA binding site [nucleotide binding]; other site 932920007641 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 932920007642 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920007643 active site 932920007644 phosphorylation site [posttranslational modification] 932920007645 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932920007646 active site 932920007647 P-loop; other site 932920007648 phosphorylation site [posttranslational modification] 932920007649 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 932920007650 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 932920007651 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 932920007652 putative substrate binding site [chemical binding]; other site 932920007653 putative ATP binding site [chemical binding]; other site 932920007654 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932920007655 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 932920007656 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932920007657 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 932920007658 trimer interface [polypeptide binding]; other site 932920007659 active site 932920007660 G bulge; other site 932920007661 Uncharacterized conserved protein [Function unknown]; Region: COG1683 932920007662 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 932920007663 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 932920007664 non-specific DNA interactions [nucleotide binding]; other site 932920007665 DNA binding site [nucleotide binding] 932920007666 sequence specific DNA binding site [nucleotide binding]; other site 932920007667 putative cAMP binding site [chemical binding]; other site 932920007668 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 932920007669 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932920007670 substrate binding site [chemical binding]; other site 932920007671 ATP binding site [chemical binding]; other site 932920007672 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 932920007673 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932920007674 RNA binding surface [nucleotide binding]; other site 932920007675 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 932920007676 active site 932920007677 uracil binding [chemical binding]; other site 932920007678 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 932920007679 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 932920007680 active site 932920007681 non-prolyl cis peptide bond; other site 932920007682 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 932920007683 catalytic residues [active] 932920007684 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 932920007685 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 932920007686 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 932920007687 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 932920007688 Walker A/P-loop; other site 932920007689 ATP binding site [chemical binding]; other site 932920007690 Q-loop/lid; other site 932920007691 ABC transporter signature motif; other site 932920007692 Walker B; other site 932920007693 D-loop; other site 932920007694 H-loop/switch region; other site 932920007695 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932920007696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920007697 dimer interface [polypeptide binding]; other site 932920007698 conserved gate region; other site 932920007699 putative PBP binding loops; other site 932920007700 ABC-ATPase subunit interface; other site 932920007701 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932920007702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920007703 dimer interface [polypeptide binding]; other site 932920007704 conserved gate region; other site 932920007705 putative PBP binding loops; other site 932920007706 ABC-ATPase subunit interface; other site 932920007707 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932920007708 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932920007709 substrate binding pocket [chemical binding]; other site 932920007710 membrane-bound complex binding site; other site 932920007711 hinge residues; other site 932920007712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920007713 Coenzyme A binding pocket [chemical binding]; other site 932920007714 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 932920007715 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 932920007716 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932920007717 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932920007718 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 932920007719 dimerization interface [polypeptide binding]; other site 932920007720 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 932920007721 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 932920007722 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 932920007723 active site 932920007724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920007725 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920007726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920007727 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920007728 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 932920007729 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 932920007730 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 932920007731 active site 932920007732 trimer interface [polypeptide binding]; other site 932920007733 allosteric site; other site 932920007734 active site lid [active] 932920007735 hexamer (dimer of trimers) interface [polypeptide binding]; other site 932920007736 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932920007737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920007738 active site 932920007739 motif I; other site 932920007740 motif II; other site 932920007741 Predicted membrane protein [Function unknown]; Region: COG1511 932920007742 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 932920007743 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 932920007744 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 932920007745 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 932920007746 Predicted transcriptional regulator [Transcription]; Region: COG1959 932920007747 Transcriptional regulator; Region: Rrf2; pfam02082 932920007748 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 932920007749 L-tyrosine decarboxylase; Provisional; Region: PRK13520 932920007750 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 932920007751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920007752 catalytic residue [active] 932920007753 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 932920007754 Mga helix-turn-helix domain; Region: Mga; pfam05043 932920007755 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 932920007756 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932920007757 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 932920007758 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932920007759 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 932920007760 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 932920007761 active site 932920007762 dimer interface [polypeptide binding]; other site 932920007763 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 932920007764 dimer interface [polypeptide binding]; other site 932920007765 active site 932920007766 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 932920007767 nudix motif; other site 932920007768 general stress protein 13; Validated; Region: PRK08059 932920007769 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 932920007770 RNA binding site [nucleotide binding]; other site 932920007771 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 932920007772 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932920007773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920007774 homodimer interface [polypeptide binding]; other site 932920007775 catalytic residue [active] 932920007776 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 932920007777 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932920007778 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932920007779 Walker A/P-loop; other site 932920007780 ATP binding site [chemical binding]; other site 932920007781 Q-loop/lid; other site 932920007782 ABC transporter signature motif; other site 932920007783 Walker B; other site 932920007784 D-loop; other site 932920007785 H-loop/switch region; other site 932920007786 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932920007787 active site 932920007788 P-loop; other site 932920007789 phosphorylation site [posttranslational modification] 932920007790 aspartate kinase; Reviewed; Region: PRK09034 932920007791 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 932920007792 putative catalytic residues [active] 932920007793 putative nucleotide binding site [chemical binding]; other site 932920007794 putative aspartate binding site [chemical binding]; other site 932920007795 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 932920007796 allosteric regulatory residue; other site 932920007797 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 932920007798 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 932920007799 active site 932920007800 drug efflux system protein MdtG; Provisional; Region: PRK09874 932920007801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920007802 putative substrate translocation pore; other site 932920007803 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 932920007804 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 932920007805 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 932920007806 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 932920007807 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 932920007808 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 932920007809 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 932920007810 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 932920007811 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 932920007812 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 932920007813 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 932920007814 CoenzymeA binding site [chemical binding]; other site 932920007815 subunit interaction site [polypeptide binding]; other site 932920007816 PHB binding site; other site 932920007817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 932920007818 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 932920007819 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 932920007820 Cl- selectivity filter; other site 932920007821 Cl- binding residues [ion binding]; other site 932920007822 pore gating glutamate residue; other site 932920007823 dimer interface [polypeptide binding]; other site 932920007824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 932920007825 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 932920007826 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932920007827 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 932920007828 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932920007829 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932920007830 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 932920007831 NADH(P)-binding; Region: NAD_binding_10; pfam13460 932920007832 NAD(P) binding site [chemical binding]; other site 932920007833 putative active site [active] 932920007834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844 932920007835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 932920007836 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920007837 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920007838 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920007839 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920007840 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920007841 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920007842 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920007843 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920007844 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 932920007845 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 932920007846 tetramer interfaces [polypeptide binding]; other site 932920007847 binuclear metal-binding site [ion binding]; other site 932920007848 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 932920007849 Domain of unknown function DUF21; Region: DUF21; pfam01595 932920007850 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 932920007851 Transporter associated domain; Region: CorC_HlyC; smart01091 932920007852 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932920007853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920007854 Coenzyme A binding pocket [chemical binding]; other site 932920007855 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 932920007856 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920007857 active site 932920007858 motif I; other site 932920007859 motif II; other site 932920007860 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920007861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 932920007862 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 932920007863 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 932920007864 active site 932920007865 metal binding site [ion binding]; metal-binding site 932920007866 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 932920007867 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 932920007868 Predicted membrane protein [Function unknown]; Region: COG4272 932920007869 Uncharacterized conserved protein [Function unknown]; Region: COG1801 932920007870 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920007871 non-specific DNA binding site [nucleotide binding]; other site 932920007872 salt bridge; other site 932920007873 sequence-specific DNA binding site [nucleotide binding]; other site 932920007874 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 932920007875 FeS assembly protein SufB; Region: sufB; TIGR01980 932920007876 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 932920007877 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 932920007878 trimerization site [polypeptide binding]; other site 932920007879 active site 932920007880 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 932920007881 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 932920007882 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932920007883 catalytic residue [active] 932920007884 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 932920007885 FeS assembly protein SufD; Region: sufD; TIGR01981 932920007886 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 932920007887 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 932920007888 Walker A/P-loop; other site 932920007889 ATP binding site [chemical binding]; other site 932920007890 Q-loop/lid; other site 932920007891 ABC transporter signature motif; other site 932920007892 Walker B; other site 932920007893 D-loop; other site 932920007894 H-loop/switch region; other site 932920007895 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 932920007896 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 932920007897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920007898 ABC-ATPase subunit interface; other site 932920007899 putative PBP binding loops; other site 932920007900 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 932920007901 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 932920007902 Walker A/P-loop; other site 932920007903 ATP binding site [chemical binding]; other site 932920007904 Q-loop/lid; other site 932920007905 ABC transporter signature motif; other site 932920007906 Walker B; other site 932920007907 D-loop; other site 932920007908 H-loop/switch region; other site 932920007909 NIL domain; Region: NIL; pfam09383 932920007910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932920007911 dimer interface [polypeptide binding]; other site 932920007912 phosphorylation site [posttranslational modification] 932920007913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920007914 ATP binding site [chemical binding]; other site 932920007915 Mg2+ binding site [ion binding]; other site 932920007916 G-X-G motif; other site 932920007917 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932920007918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920007919 active site 932920007920 phosphorylation site [posttranslational modification] 932920007921 intermolecular recognition site; other site 932920007922 dimerization interface [polypeptide binding]; other site 932920007923 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932920007924 DNA binding site [nucleotide binding] 932920007925 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 932920007926 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 932920007927 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 932920007928 catalytic residues [active] 932920007929 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 932920007930 lipoyl attachment site [posttranslational modification]; other site 932920007931 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 932920007932 ArsC family; Region: ArsC; pfam03960 932920007933 putative ArsC-like catalytic residues; other site 932920007934 putative TRX-like catalytic residues [active] 932920007935 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 932920007936 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 932920007937 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 932920007938 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 932920007939 Walker A/P-loop; other site 932920007940 ATP binding site [chemical binding]; other site 932920007941 Q-loop/lid; other site 932920007942 ABC transporter signature motif; other site 932920007943 Walker B; other site 932920007944 D-loop; other site 932920007945 H-loop/switch region; other site 932920007946 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 932920007947 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932920007948 ABC-ATPase subunit interface; other site 932920007949 dimer interface [polypeptide binding]; other site 932920007950 putative PBP binding regions; other site 932920007951 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 932920007952 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 932920007953 intersubunit interface [polypeptide binding]; other site 932920007954 Predicted esterase [General function prediction only]; Region: COG0627 932920007955 S-formylglutathione hydrolase; Region: PLN02442 932920007956 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 932920007957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920007958 catalytic residue [active] 932920007959 SdpI/YhfL protein family; Region: SdpI; pfam13630 932920007960 CAT RNA binding domain; Region: CAT_RBD; smart01061 932920007961 transcriptional antiterminator BglG; Provisional; Region: PRK09772 932920007962 PRD domain; Region: PRD; pfam00874 932920007963 PRD domain; Region: PRD; pfam00874 932920007964 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 932920007965 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 932920007966 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 932920007967 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 932920007968 Predicted transcriptional regulator [Transcription]; Region: COG2378 932920007969 HTH domain; Region: HTH_11; pfam08279 932920007970 WYL domain; Region: WYL; pfam13280 932920007971 Uncharacterized conserved protein [Function unknown]; Region: COG1434 932920007972 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 932920007973 putative active site [active] 932920007974 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 932920007975 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 932920007976 active site 932920007977 catalytic site [active] 932920007978 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 932920007979 putative metal binding site [ion binding]; other site 932920007980 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 932920007981 putative metal binding site [ion binding]; other site 932920007982 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932920007983 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 932920007984 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 932920007985 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 932920007986 active site 932920007987 catalytic site [active] 932920007988 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 932920007989 putative metal binding site [ion binding]; other site 932920007990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920007991 non-specific DNA binding site [nucleotide binding]; other site 932920007992 salt bridge; other site 932920007993 sequence-specific DNA binding site [nucleotide binding]; other site 932920007994 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 932920007995 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 932920007996 SmpB-tmRNA interface; other site 932920007997 ribonuclease R; Region: RNase_R; TIGR02063 932920007998 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 932920007999 RNB domain; Region: RNB; pfam00773 932920008000 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 932920008001 RNA binding site [nucleotide binding]; other site 932920008002 Esterase/lipase [General function prediction only]; Region: COG1647 932920008003 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 932920008004 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 932920008005 Preprotein translocase SecG subunit; Region: SecG; cl09123 932920008006 Esterase/lipase [General function prediction only]; Region: COG1647 932920008007 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 932920008008 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 932920008009 PGAP1-like protein; Region: PGAP1; pfam07819 932920008010 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 932920008011 enolase; Provisional; Region: eno; PRK00077 932920008012 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 932920008013 dimer interface [polypeptide binding]; other site 932920008014 metal binding site [ion binding]; metal-binding site 932920008015 substrate binding pocket [chemical binding]; other site 932920008016 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 932920008017 phosphoglyceromutase; Provisional; Region: PRK05434 932920008018 triosephosphate isomerase; Provisional; Region: PRK14567 932920008019 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 932920008020 substrate binding site [chemical binding]; other site 932920008021 dimer interface [polypeptide binding]; other site 932920008022 catalytic triad [active] 932920008023 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 932920008024 Phosphoglycerate kinase; Region: PGK; pfam00162 932920008025 substrate binding site [chemical binding]; other site 932920008026 hinge regions; other site 932920008027 ADP binding site [chemical binding]; other site 932920008028 catalytic site [active] 932920008029 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 932920008030 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 932920008031 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 932920008032 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 932920008033 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 932920008034 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 932920008035 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 932920008036 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 932920008037 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932920008038 DNA binding site [nucleotide binding] 932920008039 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 932920008040 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 932920008041 active site 932920008042 dimer interface [polypeptide binding]; other site 932920008043 MMPL family; Region: MMPL; pfam03176 932920008044 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 932920008045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932920008046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932920008047 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 932920008048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 932920008049 Chitin binding domain; Region: Chitin_bind_3; pfam03067 932920008050 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 932920008051 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 932920008052 Interdomain contacts; other site 932920008053 Cytokine receptor motif; other site 932920008054 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 932920008055 aromatic chitin/cellulose binding site residues [chemical binding]; other site 932920008056 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 932920008057 aromatic chitin/cellulose binding site residues [chemical binding]; other site 932920008058 Clp protease; Region: CLP_protease; pfam00574 932920008059 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 932920008060 oligomer interface [polypeptide binding]; other site 932920008061 active site residues [active] 932920008062 amino acid transporter; Region: 2A0306; TIGR00909 932920008063 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 932920008064 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932920008065 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932920008066 Substrate binding site [chemical binding]; other site 932920008067 Leucine rich repeat; Region: LRR_8; pfam13855 932920008068 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920008069 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 932920008070 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 932920008071 active site 932920008072 FMN binding site [chemical binding]; other site 932920008073 substrate binding site [chemical binding]; other site 932920008074 homotetramer interface [polypeptide binding]; other site 932920008075 catalytic residue [active] 932920008076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 932920008077 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 932920008078 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 932920008079 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 932920008080 phosphate binding site [ion binding]; other site 932920008081 putative substrate binding pocket [chemical binding]; other site 932920008082 dimer interface [polypeptide binding]; other site 932920008083 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 932920008084 AAA domain; Region: AAA_18; pfam13238 932920008085 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 932920008086 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 932920008087 active site 932920008088 substrate binding site [chemical binding]; other site 932920008089 metal binding site [ion binding]; metal-binding site 932920008090 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 932920008091 active site 932920008092 catalytic residues [active] 932920008093 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 932920008094 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 932920008095 NAD binding site [chemical binding]; other site 932920008096 homodimer interface [polypeptide binding]; other site 932920008097 active site 932920008098 substrate binding site [chemical binding]; other site 932920008099 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 932920008100 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932920008101 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932920008102 TPR repeat; Region: TPR_11; pfam13414 932920008103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932920008104 binding surface 932920008105 TPR motif; other site 932920008106 Tetratricopeptide repeat; Region: TPR_12; pfam13424 932920008107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932920008108 binding surface 932920008109 TPR motif; other site 932920008110 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 932920008111 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 932920008112 putative trimer interface [polypeptide binding]; other site 932920008113 putative CoA binding site [chemical binding]; other site 932920008114 pyrophosphatase PpaX; Provisional; Region: PRK13288 932920008115 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 932920008116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920008117 motif II; other site 932920008118 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 932920008119 HPr kinase/phosphorylase; Provisional; Region: PRK05428 932920008120 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 932920008121 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 932920008122 Hpr binding site; other site 932920008123 active site 932920008124 homohexamer subunit interaction site [polypeptide binding]; other site 932920008125 Predicted membrane protein [Function unknown]; Region: COG1950 932920008126 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 932920008127 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 932920008128 Uncharacterized conserved protein [Function unknown]; Region: COG3595 932920008129 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 932920008130 Uncharacterized conserved protein [Function unknown]; Region: COG3595 932920008131 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 932920008132 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 932920008133 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 932920008134 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 932920008135 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 932920008136 excinuclease ABC subunit B; Provisional; Region: PRK05298 932920008137 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932920008138 ATP binding site [chemical binding]; other site 932920008139 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932920008140 nucleotide binding region [chemical binding]; other site 932920008141 ATP-binding site [chemical binding]; other site 932920008142 Ultra-violet resistance protein B; Region: UvrB; pfam12344 932920008143 UvrB/uvrC motif; Region: UVR; pfam02151 932920008144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 932920008145 HD containing hydrolase-like enzyme; Region: HD_2; pfam12917 932920008146 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932920008147 dimerization interface [polypeptide binding]; other site 932920008148 putative DNA binding site [nucleotide binding]; other site 932920008149 putative Zn2+ binding site [ion binding]; other site 932920008150 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 932920008151 PhoU domain; Region: PhoU; pfam01895 932920008152 PhoU domain; Region: PhoU; pfam01895 932920008153 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 932920008154 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 932920008155 Walker A/P-loop; other site 932920008156 ATP binding site [chemical binding]; other site 932920008157 Q-loop/lid; other site 932920008158 ABC transporter signature motif; other site 932920008159 Walker B; other site 932920008160 D-loop; other site 932920008161 H-loop/switch region; other site 932920008162 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 932920008163 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 932920008164 Walker A/P-loop; other site 932920008165 ATP binding site [chemical binding]; other site 932920008166 Q-loop/lid; other site 932920008167 ABC transporter signature motif; other site 932920008168 Walker B; other site 932920008169 D-loop; other site 932920008170 H-loop/switch region; other site 932920008171 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 932920008172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920008173 dimer interface [polypeptide binding]; other site 932920008174 conserved gate region; other site 932920008175 putative PBP binding loops; other site 932920008176 ABC-ATPase subunit interface; other site 932920008177 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 932920008178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920008179 dimer interface [polypeptide binding]; other site 932920008180 conserved gate region; other site 932920008181 putative PBP binding loops; other site 932920008182 ABC-ATPase subunit interface; other site 932920008183 PBP superfamily domain; Region: PBP_like_2; cl17296 932920008184 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 932920008185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 932920008186 HAMP domain; Region: HAMP; pfam00672 932920008187 dimerization interface [polypeptide binding]; other site 932920008188 PAS domain; Region: PAS; smart00091 932920008189 putative active site [active] 932920008190 heme pocket [chemical binding]; other site 932920008191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932920008192 dimer interface [polypeptide binding]; other site 932920008193 phosphorylation site [posttranslational modification] 932920008194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920008195 ATP binding site [chemical binding]; other site 932920008196 Mg2+ binding site [ion binding]; other site 932920008197 G-X-G motif; other site 932920008198 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932920008199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920008200 active site 932920008201 phosphorylation site [posttranslational modification] 932920008202 intermolecular recognition site; other site 932920008203 dimerization interface [polypeptide binding]; other site 932920008204 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932920008205 DNA binding site [nucleotide binding] 932920008206 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 932920008207 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 932920008208 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 932920008209 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 932920008210 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 932920008211 putative active site [active] 932920008212 catalytic site [active] 932920008213 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 932920008214 putative active site [active] 932920008215 catalytic site [active] 932920008216 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 932920008217 Peptidase family M23; Region: Peptidase_M23; pfam01551 932920008218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 932920008219 NlpC/P60 family; Region: NLPC_P60; pfam00877 932920008220 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 932920008221 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 932920008222 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 932920008223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920008224 Walker A/P-loop; other site 932920008225 ATP binding site [chemical binding]; other site 932920008226 Q-loop/lid; other site 932920008227 ABC transporter signature motif; other site 932920008228 Walker B; other site 932920008229 D-loop; other site 932920008230 H-loop/switch region; other site 932920008231 Uncharacterized conserved protein [Function unknown]; Region: COG1284 932920008232 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 932920008233 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 932920008234 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 932920008235 peptide chain release factor 2; Validated; Region: prfB; PRK00578 932920008236 This domain is found in peptide chain release factors; Region: PCRF; smart00937 932920008237 RF-1 domain; Region: RF-1; pfam00472 932920008238 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 932920008239 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 932920008240 nucleotide binding region [chemical binding]; other site 932920008241 helicase superfamily c-terminal domain; Region: HELICc; smart00490 932920008242 ATP-binding site [chemical binding]; other site 932920008243 SEC-C motif; Region: SEC-C; pfam02810 932920008244 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 932920008245 30S subunit binding site; other site 932920008246 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 932920008247 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932920008248 active site 932920008249 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 932920008250 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932920008251 ATP binding site [chemical binding]; other site 932920008252 putative Mg++ binding site [ion binding]; other site 932920008253 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932920008254 nucleotide binding region [chemical binding]; other site 932920008255 ATP-binding site [chemical binding]; other site 932920008256 EDD domain protein, DegV family; Region: DegV; TIGR00762 932920008257 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 932920008258 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 932920008259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920008260 active site 932920008261 phosphorylation site [posttranslational modification] 932920008262 intermolecular recognition site; other site 932920008263 dimerization interface [polypeptide binding]; other site 932920008264 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 932920008265 DNA binding residues [nucleotide binding] 932920008266 dimerization interface [polypeptide binding]; other site 932920008267 Uncharacterized conserved protein [Function unknown]; Region: COG1739 932920008268 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 932920008269 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 932920008270 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932920008271 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932920008272 Transcriptional regulator [Transcription]; Region: LytR; COG1316 932920008273 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 932920008274 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 932920008275 Mg++ binding site [ion binding]; other site 932920008276 putative catalytic motif [active] 932920008277 substrate binding site [chemical binding]; other site 932920008278 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 932920008279 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 932920008280 active site 932920008281 octamer interface [polypeptide binding]; other site 932920008282 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 932920008283 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 932920008284 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932920008285 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932920008286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 932920008287 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 932920008288 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 932920008289 dimer interface [polypeptide binding]; other site 932920008290 ssDNA binding site [nucleotide binding]; other site 932920008291 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932920008292 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 932920008293 rod shape-determining protein Mbl; Provisional; Region: PRK13928 932920008294 MreB and similar proteins; Region: MreB_like; cd10225 932920008295 nucleotide binding site [chemical binding]; other site 932920008296 Mg binding site [ion binding]; other site 932920008297 putative protofilament interaction site [polypeptide binding]; other site 932920008298 RodZ interaction site [polypeptide binding]; other site 932920008299 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 932920008300 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 932920008301 hinge; other site 932920008302 active site 932920008303 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 932920008304 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 932920008305 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 932920008306 gamma subunit interface [polypeptide binding]; other site 932920008307 epsilon subunit interface [polypeptide binding]; other site 932920008308 LBP interface [polypeptide binding]; other site 932920008309 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 932920008310 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 932920008311 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 932920008312 alpha subunit interaction interface [polypeptide binding]; other site 932920008313 Walker A motif; other site 932920008314 ATP binding site [chemical binding]; other site 932920008315 Walker B motif; other site 932920008316 inhibitor binding site; inhibition site 932920008317 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 932920008318 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 932920008319 core domain interface [polypeptide binding]; other site 932920008320 delta subunit interface [polypeptide binding]; other site 932920008321 epsilon subunit interface [polypeptide binding]; other site 932920008322 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 932920008323 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 932920008324 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 932920008325 beta subunit interaction interface [polypeptide binding]; other site 932920008326 Walker A motif; other site 932920008327 ATP binding site [chemical binding]; other site 932920008328 Walker B motif; other site 932920008329 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 932920008330 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 932920008331 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 932920008332 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 932920008333 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 932920008334 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 932920008335 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 932920008336 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 932920008337 ATP synthase I chain; Region: ATP_synt_I; pfam03899 932920008338 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 932920008339 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 932920008340 active site 932920008341 homodimer interface [polypeptide binding]; other site 932920008342 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932920008343 active site 932920008344 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 932920008345 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 932920008346 dimer interface [polypeptide binding]; other site 932920008347 active site 932920008348 glycine-pyridoxal phosphate binding site [chemical binding]; other site 932920008349 folate binding site [chemical binding]; other site 932920008350 Low molecular weight phosphatase family; Region: LMWPc; cd00115 932920008351 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 932920008352 active site 932920008353 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 932920008354 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 932920008355 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 932920008356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920008357 S-adenosylmethionine binding site [chemical binding]; other site 932920008358 peptide chain release factor 1; Validated; Region: prfA; PRK00591 932920008359 This domain is found in peptide chain release factors; Region: PCRF; smart00937 932920008360 RF-1 domain; Region: RF-1; pfam00472 932920008361 thymidine kinase; Provisional; Region: PRK04296 932920008362 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 932920008363 ATP binding site [chemical binding]; other site 932920008364 Walker A motif; other site 932920008365 Walker B motif; other site 932920008366 homoserine kinase; Provisional; Region: PRK01212 932920008367 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 932920008368 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 932920008369 threonine synthase; Reviewed; Region: PRK06721 932920008370 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 932920008371 homodimer interface [polypeptide binding]; other site 932920008372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920008373 catalytic residue [active] 932920008374 homoserine dehydrogenase; Provisional; Region: PRK06349 932920008375 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 932920008376 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 932920008377 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 932920008378 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 932920008379 Predicted membrane protein [Function unknown]; Region: COG2246 932920008380 GtrA-like protein; Region: GtrA; pfam04138 932920008381 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 932920008382 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 932920008383 Ligand binding site; other site 932920008384 Putative Catalytic site; other site 932920008385 DXD motif; other site 932920008386 transcription termination factor Rho; Provisional; Region: rho; PRK09376 932920008387 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 932920008388 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 932920008389 RNA binding site [nucleotide binding]; other site 932920008390 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 932920008391 multimer interface [polypeptide binding]; other site 932920008392 Walker A motif; other site 932920008393 ATP binding site [chemical binding]; other site 932920008394 Walker B motif; other site 932920008395 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 932920008396 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 932920008397 hinge; other site 932920008398 active site 932920008399 Predicted integral membrane protein [Function unknown]; Region: COG0392 932920008400 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 932920008401 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 932920008402 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 932920008403 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 932920008404 putative ADP-binding pocket [chemical binding]; other site 932920008405 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 932920008406 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 932920008407 intersubunit interface [polypeptide binding]; other site 932920008408 active site 932920008409 zinc binding site [ion binding]; other site 932920008410 Na+ binding site [ion binding]; other site 932920008411 putative lipid kinase; Reviewed; Region: PRK13055 932920008412 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 932920008413 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 932920008414 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 932920008415 amidase catalytic site [active] 932920008416 Zn binding residues [ion binding]; other site 932920008417 substrate binding site [chemical binding]; other site 932920008418 SH3-like domain; Region: SH3_8; pfam13457 932920008419 SH3-like domain; Region: SH3_8; pfam13457 932920008420 SH3-like domain; Region: SH3_8; pfam13457 932920008421 SH3-like domain; Region: SH3_8; pfam13457 932920008422 CTP synthetase; Validated; Region: pyrG; PRK05380 932920008423 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 932920008424 Catalytic site [active] 932920008425 active site 932920008426 UTP binding site [chemical binding]; other site 932920008427 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 932920008428 active site 932920008429 putative oxyanion hole; other site 932920008430 catalytic triad [active] 932920008431 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 932920008432 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 932920008433 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 932920008434 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 932920008435 active site 932920008436 HIGH motif; other site 932920008437 KMSK motif region; other site 932920008438 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 932920008439 tRNA binding surface [nucleotide binding]; other site 932920008440 anticodon binding site; other site 932920008441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 932920008442 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 932920008443 Peptidase family M50; Region: Peptidase_M50; pfam02163 932920008444 active site 932920008445 putative substrate binding region [chemical binding]; other site 932920008446 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 932920008447 active site 1 [active] 932920008448 dimer interface [polypeptide binding]; other site 932920008449 hexamer interface [polypeptide binding]; other site 932920008450 active site 2 [active] 932920008451 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 932920008452 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932920008453 Zn2+ binding site [ion binding]; other site 932920008454 Mg2+ binding site [ion binding]; other site 932920008455 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 932920008456 conserved hypothetical protein TIGR01655; Region: yxeA_fam 932920008457 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 932920008458 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 932920008459 peptide binding site [polypeptide binding]; other site 932920008460 Predicted integral membrane protein [Function unknown]; Region: COG5658 932920008461 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 932920008462 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 932920008463 catalytic triad [active] 932920008464 metal binding site [ion binding]; metal-binding site 932920008465 conserved cis-peptide bond; other site 932920008466 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 932920008467 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 932920008468 folate binding site [chemical binding]; other site 932920008469 NADP+ binding site [chemical binding]; other site 932920008470 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 932920008471 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 932920008472 putative NAD(P) binding site [chemical binding]; other site 932920008473 dimer interface [polypeptide binding]; other site 932920008474 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 932920008475 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 932920008476 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 932920008477 Collagen binding domain; Region: Collagen_bind; pfam05737 932920008478 Collagen binding domain; Region: Collagen_bind; pfam05737 932920008479 Collagen binding domain; Region: Collagen_bind; pfam05737 932920008480 Cna protein B-type domain; Region: Cna_B; pfam05738 932920008481 Cna protein B-type domain; Region: Cna_B; pfam05738 932920008482 Cna protein B-type domain; Region: Cna_B; pfam05738 932920008483 Cna protein B-type domain; Region: Cna_B; pfam05738 932920008484 Cna protein B-type domain; Region: Cna_B; pfam05738 932920008485 Cna protein B-type domain; Region: Cna_B; pfam05738 932920008486 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932920008487 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932920008488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920008489 active site 932920008490 motif I; other site 932920008491 motif II; other site 932920008492 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 932920008493 Uncharacterized conserved protein [Function unknown]; Region: COG1359 932920008494 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932920008495 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932920008496 Walker A/P-loop; other site 932920008497 ATP binding site [chemical binding]; other site 932920008498 Q-loop/lid; other site 932920008499 ABC transporter signature motif; other site 932920008500 Walker B; other site 932920008501 D-loop; other site 932920008502 H-loop/switch region; other site 932920008503 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932920008504 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 932920008505 FtsX-like permease family; Region: FtsX; pfam02687 932920008506 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932920008507 dimerization interface [polypeptide binding]; other site 932920008508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932920008509 dimer interface [polypeptide binding]; other site 932920008510 phosphorylation site [posttranslational modification] 932920008511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920008512 ATP binding site [chemical binding]; other site 932920008513 Mg2+ binding site [ion binding]; other site 932920008514 G-X-G motif; other site 932920008515 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932920008516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920008517 active site 932920008518 phosphorylation site [posttranslational modification] 932920008519 intermolecular recognition site; other site 932920008520 dimerization interface [polypeptide binding]; other site 932920008521 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932920008522 DNA binding site [nucleotide binding] 932920008523 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 932920008524 Uncharacterized conserved protein [Function unknown]; Region: COG2427 932920008525 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 932920008526 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 932920008527 catalytic loop [active] 932920008528 iron binding site [ion binding]; other site 932920008529 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 932920008530 4Fe-4S binding domain; Region: Fer4; pfam00037 932920008531 4Fe-4S binding domain; Region: Fer4; pfam00037 932920008532 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 932920008533 [4Fe-4S] binding site [ion binding]; other site 932920008534 molybdopterin cofactor binding site; other site 932920008535 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 932920008536 molybdopterin cofactor binding site; other site 932920008537 Uncharacterized conserved protein [Function unknown]; Region: COG1912 932920008538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920008539 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920008540 putative substrate translocation pore; other site 932920008541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932920008542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932920008543 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 932920008544 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 932920008545 Walker A motif; other site 932920008546 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 932920008547 SH3-like domain; Region: SH3_8; pfam13457 932920008548 SH3-like domain; Region: SH3_8; pfam13457 932920008549 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932920008550 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932920008551 active site 932920008552 catalytic tetrad [active] 932920008553 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 932920008554 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 932920008555 DNA binding residues [nucleotide binding] 932920008556 putative dimer interface [polypeptide binding]; other site 932920008557 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 932920008558 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 932920008559 23S rRNA interface [nucleotide binding]; other site 932920008560 L3 interface [polypeptide binding]; other site 932920008561 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 932920008562 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 932920008563 dimerization interface 3.5A [polypeptide binding]; other site 932920008564 active site 932920008565 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 932920008566 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 932920008567 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 932920008568 Walker A/P-loop; other site 932920008569 ATP binding site [chemical binding]; other site 932920008570 Q-loop/lid; other site 932920008571 ABC transporter signature motif; other site 932920008572 Walker B; other site 932920008573 D-loop; other site 932920008574 H-loop/switch region; other site 932920008575 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 932920008576 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 932920008577 Walker A/P-loop; other site 932920008578 ATP binding site [chemical binding]; other site 932920008579 Q-loop/lid; other site 932920008580 ABC transporter signature motif; other site 932920008581 Walker B; other site 932920008582 D-loop; other site 932920008583 H-loop/switch region; other site 932920008584 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 932920008585 MgtC family; Region: MgtC; pfam02308 932920008586 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 932920008587 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 932920008588 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 932920008589 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 932920008590 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 932920008591 alphaNTD - beta interaction site [polypeptide binding]; other site 932920008592 alphaNTD homodimer interface [polypeptide binding]; other site 932920008593 alphaNTD - beta' interaction site [polypeptide binding]; other site 932920008594 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 932920008595 30S ribosomal protein S11; Validated; Region: PRK05309 932920008596 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 932920008597 30S ribosomal protein S13; Region: bact_S13; TIGR03631 932920008598 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 932920008599 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 932920008600 rRNA binding site [nucleotide binding]; other site 932920008601 predicted 30S ribosome binding site; other site 932920008602 adenylate kinase; Reviewed; Region: adk; PRK00279 932920008603 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 932920008604 AMP-binding site [chemical binding]; other site 932920008605 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 932920008606 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 932920008607 SecY translocase; Region: SecY; pfam00344 932920008608 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 932920008609 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 932920008610 23S rRNA binding site [nucleotide binding]; other site 932920008611 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 932920008612 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 932920008613 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 932920008614 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 932920008615 5S rRNA interface [nucleotide binding]; other site 932920008616 L27 interface [polypeptide binding]; other site 932920008617 23S rRNA interface [nucleotide binding]; other site 932920008618 L5 interface [polypeptide binding]; other site 932920008619 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 932920008620 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 932920008621 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 932920008622 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 932920008623 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 932920008624 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 932920008625 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 932920008626 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 932920008627 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 932920008628 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 932920008629 RNA binding site [nucleotide binding]; other site 932920008630 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 932920008631 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 932920008632 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 932920008633 23S rRNA interface [nucleotide binding]; other site 932920008634 putative translocon interaction site; other site 932920008635 signal recognition particle (SRP54) interaction site; other site 932920008636 L23 interface [polypeptide binding]; other site 932920008637 trigger factor interaction site; other site 932920008638 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 932920008639 23S rRNA interface [nucleotide binding]; other site 932920008640 5S rRNA interface [nucleotide binding]; other site 932920008641 putative antibiotic binding site [chemical binding]; other site 932920008642 L25 interface [polypeptide binding]; other site 932920008643 L27 interface [polypeptide binding]; other site 932920008644 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 932920008645 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 932920008646 G-X-X-G motif; other site 932920008647 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 932920008648 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 932920008649 putative translocon binding site; other site 932920008650 protein-rRNA interface [nucleotide binding]; other site 932920008651 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 932920008652 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 932920008653 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 932920008654 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 932920008655 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 932920008656 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 932920008657 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 932920008658 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 932920008659 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 932920008660 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 932920008661 UbiA prenyltransferase family; Region: UbiA; pfam01040 932920008662 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 932920008663 ApbE family; Region: ApbE; pfam02424 932920008664 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 932920008665 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 932920008666 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 932920008667 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 932920008668 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932920008669 Predicted membrane protein [Function unknown]; Region: COG2259 932920008670 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 932920008671 trimer interface [polypeptide binding]; other site 932920008672 Predicted membrane protein [Function unknown]; Region: COG4769 932920008673 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 932920008674 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 932920008675 substrate binding pocket [chemical binding]; other site 932920008676 chain length determination region; other site 932920008677 substrate-Mg2+ binding site; other site 932920008678 catalytic residues [active] 932920008679 aspartate-rich region 1; other site 932920008680 active site lid residues [active] 932920008681 aspartate-rich region 2; other site 932920008682 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 932920008683 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 932920008684 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 932920008685 active site 932920008686 metal binding site [ion binding]; metal-binding site 932920008687 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 932920008688 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 932920008689 hypothetical protein; Provisional; Region: PRK02947 932920008690 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932920008691 putative active site [active] 932920008692 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 932920008693 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 932920008694 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 932920008695 active site 932920008696 substrate binding pocket [chemical binding]; other site 932920008697 homodimer interaction site [polypeptide binding]; other site 932920008698 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 932920008699 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 932920008700 active site 932920008701 P-loop; other site 932920008702 phosphorylation site [posttranslational modification] 932920008703 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920008704 active site 932920008705 phosphorylation site [posttranslational modification] 932920008706 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932920008707 Mga helix-turn-helix domain; Region: Mga; pfam05043 932920008708 PRD domain; Region: PRD; pfam00874 932920008709 PRD domain; Region: PRD; pfam00874 932920008710 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932920008711 active site 932920008712 P-loop; other site 932920008713 phosphorylation site [posttranslational modification] 932920008714 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920008715 active site 932920008716 phosphorylation site [posttranslational modification] 932920008717 elongation factor Tu; Reviewed; Region: PRK00049 932920008718 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 932920008719 G1 box; other site 932920008720 GEF interaction site [polypeptide binding]; other site 932920008721 GTP/Mg2+ binding site [chemical binding]; other site 932920008722 Switch I region; other site 932920008723 G2 box; other site 932920008724 G3 box; other site 932920008725 Switch II region; other site 932920008726 G4 box; other site 932920008727 G5 box; other site 932920008728 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 932920008729 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 932920008730 Antibiotic Binding Site [chemical binding]; other site 932920008731 elongation factor G; Reviewed; Region: PRK00007 932920008732 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 932920008733 G1 box; other site 932920008734 putative GEF interaction site [polypeptide binding]; other site 932920008735 GTP/Mg2+ binding site [chemical binding]; other site 932920008736 Switch I region; other site 932920008737 G2 box; other site 932920008738 G3 box; other site 932920008739 Switch II region; other site 932920008740 G4 box; other site 932920008741 G5 box; other site 932920008742 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 932920008743 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 932920008744 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 932920008745 30S ribosomal protein S7; Validated; Region: PRK05302 932920008746 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 932920008747 S17 interaction site [polypeptide binding]; other site 932920008748 S8 interaction site; other site 932920008749 16S rRNA interaction site [nucleotide binding]; other site 932920008750 streptomycin interaction site [chemical binding]; other site 932920008751 23S rRNA interaction site [nucleotide binding]; other site 932920008752 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 932920008753 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 932920008754 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932920008755 Zn2+ binding site [ion binding]; other site 932920008756 Mg2+ binding site [ion binding]; other site 932920008757 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 932920008758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920008759 Coenzyme A binding pocket [chemical binding]; other site 932920008760 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 932920008761 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 932920008762 substrate binding site [chemical binding]; other site 932920008763 hexamer interface [polypeptide binding]; other site 932920008764 metal binding site [ion binding]; metal-binding site 932920008765 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 932920008766 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 932920008767 TPP-binding site [chemical binding]; other site 932920008768 dimer interface [polypeptide binding]; other site 932920008769 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 932920008770 PYR/PP interface [polypeptide binding]; other site 932920008771 dimer interface [polypeptide binding]; other site 932920008772 TPP binding site [chemical binding]; other site 932920008773 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 932920008774 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 932920008775 substrate binding site [chemical binding]; other site 932920008776 hexamer interface [polypeptide binding]; other site 932920008777 metal binding site [ion binding]; metal-binding site 932920008778 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 932920008779 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 932920008780 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 932920008781 putative NAD(P) binding site [chemical binding]; other site 932920008782 catalytic Zn binding site [ion binding]; other site 932920008783 structural Zn binding site [ion binding]; other site 932920008784 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 932920008785 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 932920008786 putative NAD(P) binding site [chemical binding]; other site 932920008787 catalytic Zn binding site [ion binding]; other site 932920008788 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 932920008789 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 932920008790 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 932920008791 active site 932920008792 P-loop; other site 932920008793 phosphorylation site [posttranslational modification] 932920008794 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920008795 active site 932920008796 phosphorylation site [posttranslational modification] 932920008797 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932920008798 PRD domain; Region: PRD; pfam00874 932920008799 PRD domain; Region: PRD; pfam00874 932920008800 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932920008801 active site 932920008802 P-loop; other site 932920008803 phosphorylation site [posttranslational modification] 932920008804 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920008805 active site 932920008806 phosphorylation site [posttranslational modification] 932920008807 Predicted membrane protein [Function unknown]; Region: COG4905 932920008808 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 932920008809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 932920008810 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 932920008811 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932920008812 active site 932920008813 Helix-turn-helix domain; Region: HTH_18; pfam12833 932920008814 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 932920008815 Ligand Binding Site [chemical binding]; other site 932920008816 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 932920008817 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 932920008818 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 932920008819 active site 932920008820 DNA binding site [nucleotide binding] 932920008821 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 932920008822 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 932920008823 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 932920008824 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 932920008825 active site 932920008826 DNA binding site [nucleotide binding] 932920008827 Int/Topo IB signature motif; other site 932920008828 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 932920008829 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 932920008830 active site 932920008831 DNA binding site [nucleotide binding] 932920008832 Int/Topo IB signature motif; other site 932920008833 Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; Region: Cby_like; cd07429 932920008834 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 932920008835 DNA polymerase IV; Reviewed; Region: PRK03103 932920008836 active site 932920008837 DNA binding site [nucleotide binding] 932920008838 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 932920008839 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 932920008840 Low molecular weight phosphatase family; Region: LMWPc; cd00115 932920008841 active site 932920008842 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 932920008843 Sodium Bile acid symporter family; Region: SBF; cl17470 932920008844 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 932920008845 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 932920008846 P loop; other site 932920008847 Nucleotide binding site [chemical binding]; other site 932920008848 DTAP/Switch II; other site 932920008849 Switch I; other site 932920008850 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 932920008851 P loop; other site 932920008852 Nucleotide binding site [chemical binding]; other site 932920008853 DTAP/Switch II; other site 932920008854 Switch I; other site 932920008855 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 932920008856 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932920008857 dimerization interface [polypeptide binding]; other site 932920008858 putative DNA binding site [nucleotide binding]; other site 932920008859 putative Zn2+ binding site [ion binding]; other site 932920008860 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 932920008861 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932920008862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932920008863 active site 932920008864 phosphorylation site [posttranslational modification] 932920008865 intermolecular recognition site; other site 932920008866 dimerization interface [polypeptide binding]; other site 932920008867 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932920008868 DNA binding site [nucleotide binding] 932920008869 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 932920008870 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 932920008871 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 932920008872 Ligand Binding Site [chemical binding]; other site 932920008873 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 932920008874 GAF domain; Region: GAF_3; pfam13492 932920008875 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932920008876 dimer interface [polypeptide binding]; other site 932920008877 phosphorylation site [posttranslational modification] 932920008878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932920008879 ATP binding site [chemical binding]; other site 932920008880 Mg2+ binding site [ion binding]; other site 932920008881 G-X-G motif; other site 932920008882 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 932920008883 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 932920008884 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932920008885 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 932920008886 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932920008887 active site 932920008888 P-loop; other site 932920008889 phosphorylation site [posttranslational modification] 932920008890 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932920008891 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932920008892 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932920008893 methionine cluster; other site 932920008894 active site 932920008895 phosphorylation site [posttranslational modification] 932920008896 metal binding site [ion binding]; metal-binding site 932920008897 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 932920008898 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 932920008899 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 932920008900 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 932920008901 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932920008902 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 932920008903 Soluble P-type ATPase [General function prediction only]; Region: COG4087 932920008904 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 932920008905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932920008906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932920008907 autolysin; Reviewed; Region: PRK06347 932920008908 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 932920008909 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932920008910 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932920008911 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932920008912 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932920008913 Protein of unknown function (DUF970); Region: DUF970; pfam06153 932920008914 thymidylate kinase; Validated; Region: tmk; PRK00698 932920008915 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 932920008916 TMP-binding site; other site 932920008917 ATP-binding site [chemical binding]; other site 932920008918 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 932920008919 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 932920008920 homodimer interface [polypeptide binding]; other site 932920008921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920008922 catalytic residue [active] 932920008923 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 932920008924 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 932920008925 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 932920008926 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 932920008927 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 932920008928 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 932920008929 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932920008930 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932920008931 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932920008932 putative active site [active] 932920008933 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932920008934 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920008935 active site 932920008936 motif I; other site 932920008937 motif II; other site 932920008938 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 932920008939 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932920008940 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932920008941 active site 932920008942 catalytic tetrad [active] 932920008943 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 932920008944 recombination protein RecR; Reviewed; Region: recR; PRK00076 932920008945 RecR protein; Region: RecR; pfam02132 932920008946 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 932920008947 putative active site [active] 932920008948 putative metal-binding site [ion binding]; other site 932920008949 tetramer interface [polypeptide binding]; other site 932920008950 hypothetical protein; Validated; Region: PRK00153 932920008951 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 932920008952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920008953 Walker A motif; other site 932920008954 ATP binding site [chemical binding]; other site 932920008955 Walker B motif; other site 932920008956 arginine finger; other site 932920008957 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 932920008958 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 932920008959 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 932920008960 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932920008961 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932920008962 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 932920008963 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 932920008964 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 932920008965 N- and C-terminal domain interface [polypeptide binding]; other site 932920008966 active site 932920008967 catalytic site [active] 932920008968 metal binding site [ion binding]; metal-binding site 932920008969 carbohydrate binding site [chemical binding]; other site 932920008970 ATP binding site [chemical binding]; other site 932920008971 SH3-like domain; Region: SH3_8; pfam13457 932920008972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 932920008973 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 932920008974 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932920008975 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 932920008976 Walker A/P-loop; other site 932920008977 ATP binding site [chemical binding]; other site 932920008978 Q-loop/lid; other site 932920008979 ABC transporter signature motif; other site 932920008980 Walker B; other site 932920008981 D-loop; other site 932920008982 H-loop/switch region; other site 932920008983 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 932920008984 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932920008985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920008986 Walker A/P-loop; other site 932920008987 ATP binding site [chemical binding]; other site 932920008988 Q-loop/lid; other site 932920008989 ABC transporter signature motif; other site 932920008990 Walker B; other site 932920008991 D-loop; other site 932920008992 H-loop/switch region; other site 932920008993 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 932920008994 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 932920008995 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 932920008996 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 932920008997 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 932920008998 nucleoside/Zn binding site; other site 932920008999 dimer interface [polypeptide binding]; other site 932920009000 catalytic motif [active] 932920009001 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 932920009002 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 932920009003 active site 932920009004 acyl-activating enzyme (AAE) consensus motif; other site 932920009005 putative CoA binding site [chemical binding]; other site 932920009006 AMP binding site [chemical binding]; other site 932920009007 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 932920009008 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 932920009009 active site 932920009010 trimer interface [polypeptide binding]; other site 932920009011 allosteric site; other site 932920009012 active site lid [active] 932920009013 hexamer (dimer of trimers) interface [polypeptide binding]; other site 932920009014 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 932920009015 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 932920009016 DNA binding residues [nucleotide binding] 932920009017 drug binding residues [chemical binding]; other site 932920009018 dimer interface [polypeptide binding]; other site 932920009019 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 932920009020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932920009021 Coenzyme A binding pocket [chemical binding]; other site 932920009022 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 932920009023 dimer interface [polypeptide binding]; other site 932920009024 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 932920009025 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 932920009026 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932920009027 MarR family; Region: MarR; pfam01047 932920009028 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 932920009029 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 932920009030 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 932920009031 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 932920009032 DNA binding residues [nucleotide binding] 932920009033 putative dimer interface [polypeptide binding]; other site 932920009034 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 932920009035 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 932920009036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920009037 active site 932920009038 motif I; other site 932920009039 motif II; other site 932920009040 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932920009041 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932920009042 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932920009043 putative active site [active] 932920009044 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 932920009045 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920009046 active site 932920009047 phosphorylation site [posttranslational modification] 932920009048 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932920009049 active site 932920009050 P-loop; other site 932920009051 phosphorylation site [posttranslational modification] 932920009052 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 932920009053 alpha-mannosidase; Provisional; Region: PRK09819 932920009054 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 932920009055 active site 932920009056 metal binding site [ion binding]; metal-binding site 932920009057 catalytic site [active] 932920009058 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 932920009059 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 932920009060 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 932920009061 active site 932920009062 homodimer interface [polypeptide binding]; other site 932920009063 catalytic site [active] 932920009064 glycerate kinase; Region: TIGR00045 932920009065 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932920009066 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932920009067 DNA binding site [nucleotide binding] 932920009068 domain linker motif; other site 932920009069 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 932920009070 putative dimerization interface [polypeptide binding]; other site 932920009071 putative ligand binding site [chemical binding]; other site 932920009072 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 932920009073 Domain of unknown function DUF21; Region: DUF21; pfam01595 932920009074 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 932920009075 Transporter associated domain; Region: CorC_HlyC; pfam03471 932920009076 NAD-dependent deacetylase; Provisional; Region: PRK00481 932920009077 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 932920009078 NAD+ binding site [chemical binding]; other site 932920009079 substrate binding site [chemical binding]; other site 932920009080 putative Zn binding site [ion binding]; other site 932920009081 Pathogenicity locus; Region: Cdd1; pfam11731 932920009082 drug efflux system protein MdtG; Provisional; Region: PRK09874 932920009083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920009084 putative substrate translocation pore; other site 932920009085 Src Homology 3 domain superfamily; Region: SH3; cl17036 932920009086 Variant SH3 domain; Region: SH3_2; pfam07653 932920009087 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 932920009088 active site 932920009089 intersubunit interactions; other site 932920009090 catalytic residue [active] 932920009091 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932920009092 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932920009093 ligand binding site [chemical binding]; other site 932920009094 flexible hinge region; other site 932920009095 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 932920009096 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932920009097 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932920009098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920009099 Walker A/P-loop; other site 932920009100 ATP binding site [chemical binding]; other site 932920009101 Q-loop/lid; other site 932920009102 ABC transporter signature motif; other site 932920009103 Walker B; other site 932920009104 D-loop; other site 932920009105 H-loop/switch region; other site 932920009106 TfoX C-terminal domain; Region: TfoX_C; pfam04994 932920009107 seryl-tRNA synthetase; Provisional; Region: PRK05431 932920009108 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 932920009109 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 932920009110 dimer interface [polypeptide binding]; other site 932920009111 active site 932920009112 motif 1; other site 932920009113 motif 2; other site 932920009114 motif 3; other site 932920009115 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 932920009116 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 932920009117 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 932920009118 Glutamine amidotransferase class-I; Region: GATase; pfam00117 932920009119 glutamine binding [chemical binding]; other site 932920009120 catalytic triad [active] 932920009121 aminodeoxychorismate synthase; Provisional; Region: PRK07508 932920009122 chorismate binding enzyme; Region: Chorismate_bind; cl10555 932920009123 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 932920009124 substrate-cofactor binding pocket; other site 932920009125 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 932920009126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932920009127 catalytic residue [active] 932920009128 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932920009129 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932920009130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920009131 Walker A/P-loop; other site 932920009132 ATP binding site [chemical binding]; other site 932920009133 Q-loop/lid; other site 932920009134 ABC transporter signature motif; other site 932920009135 Walker B; other site 932920009136 D-loop; other site 932920009137 H-loop/switch region; other site 932920009138 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932920009139 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932920009140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932920009141 Walker A/P-loop; other site 932920009142 ATP binding site [chemical binding]; other site 932920009143 Q-loop/lid; other site 932920009144 ABC transporter signature motif; other site 932920009145 Walker B; other site 932920009146 D-loop; other site 932920009147 H-loop/switch region; other site 932920009148 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 932920009149 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 932920009150 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 932920009151 Predicted acyl esterases [General function prediction only]; Region: COG2936 932920009152 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 932920009153 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 932920009154 DNA topoisomerase III; Provisional; Region: PRK07726 932920009155 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 932920009156 active site 932920009157 putative interdomain interaction site [polypeptide binding]; other site 932920009158 putative metal-binding site [ion binding]; other site 932920009159 putative nucleotide binding site [chemical binding]; other site 932920009160 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 932920009161 domain I; other site 932920009162 DNA binding groove [nucleotide binding] 932920009163 phosphate binding site [ion binding]; other site 932920009164 domain II; other site 932920009165 domain III; other site 932920009166 nucleotide binding site [chemical binding]; other site 932920009167 catalytic site [active] 932920009168 domain IV; other site 932920009169 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 932920009170 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 932920009171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932920009172 ATP binding site [chemical binding]; other site 932920009173 putative Mg++ binding site [ion binding]; other site 932920009174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932920009175 nucleotide binding region [chemical binding]; other site 932920009176 ATP-binding site [chemical binding]; other site 932920009177 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 932920009178 HRDC domain; Region: HRDC; pfam00570 932920009179 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 932920009180 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 932920009181 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 932920009182 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 932920009183 active site 932920009184 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 932920009185 putative ADP-ribose binding site [chemical binding]; other site 932920009186 putative active site [active] 932920009187 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 932920009188 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932920009189 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932920009190 ABC transporter; Region: ABC_tran_2; pfam12848 932920009191 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932920009192 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932920009193 beta-galactosidase; Region: BGL; TIGR03356 932920009194 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932920009195 active site 932920009196 P-loop; other site 932920009197 phosphorylation site [posttranslational modification] 932920009198 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932920009199 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932920009200 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932920009201 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932920009202 nucleotide binding site [chemical binding]; other site 932920009203 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932920009204 methionine cluster; other site 932920009205 active site 932920009206 phosphorylation site [posttranslational modification] 932920009207 metal binding site [ion binding]; metal-binding site 932920009208 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932920009209 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932920009210 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932920009211 putative active site [active] 932920009212 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 932920009213 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 932920009214 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 932920009215 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 932920009216 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 932920009217 Walker A/P-loop; other site 932920009218 ATP binding site [chemical binding]; other site 932920009219 Q-loop/lid; other site 932920009220 ABC transporter signature motif; other site 932920009221 Walker B; other site 932920009222 D-loop; other site 932920009223 H-loop/switch region; other site 932920009224 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 932920009225 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 932920009226 ATP-grasp domain; Region: ATP-grasp_4; cl17255 932920009227 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 932920009228 beta-galactosidase; Region: BGL; TIGR03356 932920009229 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 932920009230 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932920009231 active site turn [active] 932920009232 phosphorylation site [posttranslational modification] 932920009233 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932920009234 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 932920009235 HPr interaction site; other site 932920009236 glycerol kinase (GK) interaction site [polypeptide binding]; other site 932920009237 active site 932920009238 phosphorylation site [posttranslational modification] 932920009239 transcriptional antiterminator BglG; Provisional; Region: PRK09772 932920009240 CAT RNA binding domain; Region: CAT_RBD; smart01061 932920009241 PRD domain; Region: PRD; pfam00874 932920009242 PRD domain; Region: PRD; pfam00874 932920009243 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932920009244 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 932920009245 Walker A/P-loop; other site 932920009246 ATP binding site [chemical binding]; other site 932920009247 Q-loop/lid; other site 932920009248 ABC transporter signature motif; other site 932920009249 Walker B; other site 932920009250 D-loop; other site 932920009251 H-loop/switch region; other site 932920009252 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 932920009253 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 932920009254 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 932920009255 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 932920009256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920009257 putative substrate translocation pore; other site 932920009258 GTP-binding protein YchF; Reviewed; Region: PRK09601 932920009259 YchF GTPase; Region: YchF; cd01900 932920009260 G1 box; other site 932920009261 GTP/Mg2+ binding site [chemical binding]; other site 932920009262 Switch I region; other site 932920009263 G2 box; other site 932920009264 Switch II region; other site 932920009265 G3 box; other site 932920009266 G4 box; other site 932920009267 G5 box; other site 932920009268 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 932920009269 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932920009270 methionine cluster; other site 932920009271 active site 932920009272 phosphorylation site [posttranslational modification] 932920009273 metal binding site [ion binding]; metal-binding site 932920009274 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 932920009275 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 932920009276 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 932920009277 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932920009278 active site 932920009279 P-loop; other site 932920009280 phosphorylation site [posttranslational modification] 932920009281 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932920009282 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 932920009283 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932920009284 HTH domain; Region: HTH_11; pfam08279 932920009285 Mga helix-turn-helix domain; Region: Mga; pfam05043 932920009286 PRD domain; Region: PRD; pfam00874 932920009287 PRD domain; Region: PRD; pfam00874 932920009288 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932920009289 active site 932920009290 P-loop; other site 932920009291 phosphorylation site [posttranslational modification] 932920009292 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920009293 active site 932920009294 phosphorylation site [posttranslational modification] 932920009295 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 932920009296 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 932920009297 tetramer interface [polypeptide binding]; other site 932920009298 heme binding pocket [chemical binding]; other site 932920009299 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 932920009300 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 932920009301 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932920009302 active site turn [active] 932920009303 phosphorylation site [posttranslational modification] 932920009304 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932920009305 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 932920009306 HPr interaction site; other site 932920009307 glycerol kinase (GK) interaction site [polypeptide binding]; other site 932920009308 active site 932920009309 phosphorylation site [posttranslational modification] 932920009310 transcriptional antiterminator BglG; Provisional; Region: PRK09772 932920009311 CAT RNA binding domain; Region: CAT_RBD; pfam03123 932920009312 PRD domain; Region: PRD; pfam00874 932920009313 PRD domain; Region: PRD; pfam00874 932920009314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 932920009315 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 932920009316 ParB-like nuclease domain; Region: ParB; smart00470 932920009317 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 932920009318 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 932920009319 P-loop; other site 932920009320 Magnesium ion binding site [ion binding]; other site 932920009321 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 932920009322 Magnesium ion binding site [ion binding]; other site 932920009323 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 932920009324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920009325 non-specific DNA binding site [nucleotide binding]; other site 932920009326 salt bridge; other site 932920009327 sequence-specific DNA binding site [nucleotide binding]; other site 932920009328 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 932920009329 ParB-like nuclease domain; Region: ParBc; pfam02195 932920009330 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932920009331 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932920009332 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932920009333 putative active site [active] 932920009334 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932920009335 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932920009336 nucleotide binding site [chemical binding]; other site 932920009337 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932920009338 active site 932920009339 phosphorylation site [posttranslational modification] 932920009340 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 932920009341 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920009342 motif II; other site 932920009343 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 932920009344 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 932920009345 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 932920009346 active site 932920009347 P-loop; other site 932920009348 phosphorylation site [posttranslational modification] 932920009349 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932920009350 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932920009351 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932920009352 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 932920009353 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 932920009354 putative active site cavity [active] 932920009355 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 932920009356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932920009357 S-adenosylmethionine binding site [chemical binding]; other site 932920009358 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 932920009359 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 932920009360 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 932920009361 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 932920009362 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 932920009363 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 932920009364 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 932920009365 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 932920009366 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 932920009367 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 932920009368 trmE is a tRNA modification GTPase; Region: trmE; cd04164 932920009369 G1 box; other site 932920009370 GTP/Mg2+ binding site [chemical binding]; other site 932920009371 Switch I region; other site 932920009372 G2 box; other site 932920009373 Switch II region; other site 932920009374 G3 box; other site 932920009375 G4 box; other site 932920009376 G5 box; other site 932920009377 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 932920009378 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 932920009379 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 932920009380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932920009381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932920009382 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 932920009383 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 932920009384 NADP binding site [chemical binding]; other site 932920009385 homodimer interface [polypeptide binding]; other site 932920009386 active site 932920009387 substrate binding site [chemical binding]; other site 932920009388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920009389 D-galactonate transporter; Region: 2A0114; TIGR00893 932920009390 putative substrate translocation pore; other site 932920009391 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 932920009392 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 932920009393 metal binding site [ion binding]; metal-binding site 932920009394 dimer interface [polypeptide binding]; other site 932920009395 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 932920009396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 932920009397 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 932920009398 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 932920009399 metal binding site [ion binding]; metal-binding site 932920009400 dimer interface [polypeptide binding]; other site 932920009401 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932920009402 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932920009403 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 932920009404 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932920009405 Leucine-rich repeats; other site 932920009406 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920009407 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920009408 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932920009409 Substrate binding site [chemical binding]; other site 932920009410 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920009411 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920009412 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920009413 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932920009414 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932920009415 Uncharacterized conserved protein [Function unknown]; Region: COG4198 932920009416 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 932920009417 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 932920009418 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 932920009419 putative ligand binding site [chemical binding]; other site 932920009420 putative NAD binding site [chemical binding]; other site 932920009421 putative catalytic site [active] 932920009422 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 932920009423 L-serine binding site [chemical binding]; other site 932920009424 ACT domain interface; other site 932920009425 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 932920009426 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932920009427 catalytic residue [active] 932920009428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920009429 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920009430 putative substrate translocation pore; other site 932920009431 Transcriptional regulators [Transcription]; Region: MarR; COG1846 932920009432 MarR family; Region: MarR_2; pfam12802 932920009433 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 932920009434 dimer interface [polypeptide binding]; other site 932920009435 FMN binding site [chemical binding]; other site 932920009436 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 932920009437 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 932920009438 catalytic residues [active] 932920009439 beta-phosphoglucomutase; Region: bPGM; TIGR01990 932920009440 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 932920009441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932920009442 motif II; other site 932920009443 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 932920009444 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 932920009445 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 932920009446 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 932920009447 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 932920009448 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932920009449 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932920009450 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932920009451 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 932920009452 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 932920009453 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 932920009454 putative NAD(P) binding site [chemical binding]; other site 932920009455 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932920009456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920009457 dimer interface [polypeptide binding]; other site 932920009458 conserved gate region; other site 932920009459 putative PBP binding loops; other site 932920009460 ABC-ATPase subunit interface; other site 932920009461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932920009462 dimer interface [polypeptide binding]; other site 932920009463 conserved gate region; other site 932920009464 putative PBP binding loops; other site 932920009465 ABC-ATPase subunit interface; other site 932920009466 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 932920009467 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932920009468 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 932920009469 sucrose phosphorylase; Provisional; Region: PRK13840 932920009470 active site 932920009471 homodimer interface [polypeptide binding]; other site 932920009472 catalytic site [active] 932920009473 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932920009474 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932920009475 DNA binding site [nucleotide binding] 932920009476 domain linker motif; other site 932920009477 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 932920009478 putative dimerization interface [polypeptide binding]; other site 932920009479 putative ligand binding site [chemical binding]; other site 932920009480 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 932920009481 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 932920009482 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932920009483 Coenzyme A binding pocket [chemical binding]; other site 932920009484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920009485 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920009486 putative substrate translocation pore; other site 932920009487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920009488 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 932920009489 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 932920009490 intersubunit interface [polypeptide binding]; other site 932920009491 active site 932920009492 Zn2+ binding site [ion binding]; other site 932920009493 L-rhamnose isomerase; Provisional; Region: PRK01076 932920009494 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 932920009495 N- and C-terminal domain interface [polypeptide binding]; other site 932920009496 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 932920009497 active site 932920009498 putative catalytic site [active] 932920009499 metal binding site [ion binding]; metal-binding site 932920009500 ATP binding site [chemical binding]; other site 932920009501 carbohydrate binding site [chemical binding]; other site 932920009502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932920009503 putative substrate translocation pore; other site 932920009504 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932920009505 Cupin domain; Region: Cupin_2; pfam07883 932920009506 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932920009507 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 932920009508 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 932920009509 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 932920009510 G-X-X-G motif; other site 932920009511 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 932920009512 RxxxH motif; other site 932920009513 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 932920009514 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 932920009515 ribonuclease P; Reviewed; Region: rnpA; PRK00499 932920009516 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 932920009517 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 932920009518 Integrase core domain; Region: rve; pfam00665 932920009519 Integrase core domain; Region: rve_3; pfam13683 932920009520 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 932920009521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920009522 Walker A motif; other site 932920009523 ATP binding site [chemical binding]; other site 932920009524 Walker B motif; other site 932920009525 arginine finger; other site 932920009526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 932920009527 Integrase core domain; Region: rve; pfam00665 932920009528 Fic family protein [Function unknown]; Region: COG3177 932920009529 Fic/DOC family; Region: Fic; pfam02661 932920009530 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932920009531 non-specific DNA binding site [nucleotide binding]; other site 932920009532 salt bridge; other site 932920009533 sequence-specific DNA binding site [nucleotide binding]; other site 932920009534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 932920009535 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 932920009536 Integrase core domain; Region: rve; pfam00665 932920009537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 932920009538 Integrase core domain; Region: rve; pfam00665 932920009539 Domain of unknown function DUF87; Region: DUF87; pfam01935 932920009540 HerA helicase [Replication, recombination, and repair]; Region: COG0433 932920009541 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 932920009542 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 932920009543 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 932920009544 catalytic residues [active] 932920009545 catalytic nucleophile [active] 932920009546 Presynaptic Site I dimer interface [polypeptide binding]; other site 932920009547 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 932920009548 Synaptic Flat tetramer interface [polypeptide binding]; other site 932920009549 Synaptic Site I dimer interface [polypeptide binding]; other site 932920009550 DNA binding site [nucleotide binding] 932920009551 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 932920009552 DNA-binding interface [nucleotide binding]; DNA binding site 932920009553 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 932920009554 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932920009555 Soluble P-type ATPase [General function prediction only]; Region: COG4087 932920009556 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 932920009557 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 932920009558 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 932920009559 multiple promoter invertase; Provisional; Region: mpi; PRK13413 932920009560 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 932920009561 catalytic residues [active] 932920009562 catalytic nucleophile [active] 932920009563 Presynaptic Site I dimer interface [polypeptide binding]; other site 932920009564 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 932920009565 Synaptic Flat tetramer interface [polypeptide binding]; other site 932920009566 Synaptic Site I dimer interface [polypeptide binding]; other site 932920009567 DNA binding site [nucleotide binding] 932920009568 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 932920009569 DNA-binding interface [nucleotide binding]; DNA binding site 932920009570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932920009571 dimerization interface [polypeptide binding]; other site 932920009572 putative DNA binding site [nucleotide binding]; other site 932920009573 putative Zn2+ binding site [ion binding]; other site 932920009574 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 932920009575 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 932920009576 metal-binding site [ion binding] 932920009577 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932920009578 Soluble P-type ATPase [General function prediction only]; Region: COG4087 932920009579 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 932920009580 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 932920009581 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 932920009582 AP2 domain; Region: AP2; pfam00847 932920009583 putative transposase OrfB; Reviewed; Region: PHA02517 932920009584 HTH-like domain; Region: HTH_21; pfam13276 932920009585 Integrase core domain; Region: rve; pfam00665 932920009586 Integrase core domain; Region: rve_3; pfam13683 932920009587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 932920009588 Transposase; Region: HTH_Tnp_1; cl17663 932920009589 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 932920009590 multiple promoter invertase; Provisional; Region: mpi; PRK13413 932920009591 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 932920009592 catalytic residues [active] 932920009593 catalytic nucleophile [active] 932920009594 Presynaptic Site I dimer interface [polypeptide binding]; other site 932920009595 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 932920009596 Synaptic Flat tetramer interface [polypeptide binding]; other site 932920009597 Synaptic Site I dimer interface [polypeptide binding]; other site 932920009598 DNA binding site [nucleotide binding] 932920009599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920009600 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 932920009601 Walker A motif; other site 932920009602 ATP binding site [chemical binding]; other site 932920009603 Walker B motif; other site 932920009604 arginine finger; other site 932920009605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932920009606 Walker A motif; other site 932920009607 ATP binding site [chemical binding]; other site 932920009608 Walker B motif; other site 932920009609 arginine finger; other site 932920009610 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 932920009611 Helix-turn-helix domain; Region: HTH_28; pfam13518 932920009612 putative transposase OrfB; Reviewed; Region: PHA02517 932920009613 HTH-like domain; Region: HTH_21; pfam13276 932920009614 Integrase core domain; Region: rve; pfam00665 932920009615 Integrase core domain; Region: rve_3; pfam13683 932920009616 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 932920009617 P-loop; other site 932920009618 Magnesium ion binding site [ion binding]; other site 932920009619 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 932920009620 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 932920009621 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 932920009622 active site 932920009623 DNA binding site [nucleotide binding] 932920009624 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 932920009625 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 932920009626 P-loop; other site 932920009627 Magnesium ion binding site [ion binding]; other site 932920009628 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 932920009629 Magnesium ion binding site [ion binding]; other site