-- dump date 20140619_134145 -- class Genbank::misc_feature -- table misc_feature_note -- id note 882097000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 882097000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 882097000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097000004 Walker A motif; other site 882097000005 ATP binding site [chemical binding]; other site 882097000006 Walker B motif; other site 882097000007 arginine finger; other site 882097000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 882097000009 DnaA box-binding interface [nucleotide binding]; other site 882097000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 882097000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 882097000012 putative DNA binding surface [nucleotide binding]; other site 882097000013 dimer interface [polypeptide binding]; other site 882097000014 beta-clamp/clamp loader binding surface; other site 882097000015 beta-clamp/translesion DNA polymerase binding surface; other site 882097000016 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 882097000017 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 882097000018 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 882097000019 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 882097000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 882097000021 Walker A/P-loop; other site 882097000022 ATP binding site [chemical binding]; other site 882097000023 Q-loop/lid; other site 882097000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097000025 ABC transporter signature motif; other site 882097000026 Walker B; other site 882097000027 D-loop; other site 882097000028 H-loop/switch region; other site 882097000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 882097000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097000031 Mg2+ binding site [ion binding]; other site 882097000032 G-X-G motif; other site 882097000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 882097000034 anchoring element; other site 882097000035 dimer interface [polypeptide binding]; other site 882097000036 ATP binding site [chemical binding]; other site 882097000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 882097000038 active site 882097000039 putative metal-binding site [ion binding]; other site 882097000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 882097000041 DNA gyrase subunit A; Validated; Region: PRK05560 882097000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 882097000043 CAP-like domain; other site 882097000044 active site 882097000045 primary dimer interface [polypeptide binding]; other site 882097000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882097000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882097000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882097000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882097000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882097000051 cardiolipin synthetase; Reviewed; Region: PRK12452 882097000052 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 882097000053 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 882097000054 putative active site [active] 882097000055 catalytic site [active] 882097000056 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 882097000057 putative active site [active] 882097000058 catalytic site [active] 882097000059 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 882097000060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097000061 Coenzyme A binding pocket [chemical binding]; other site 882097000062 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 882097000063 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 882097000064 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 882097000065 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 882097000066 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 882097000067 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 882097000068 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 882097000069 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 882097000070 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 882097000071 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 882097000072 D-pathway; other site 882097000073 Putative ubiquinol binding site [chemical binding]; other site 882097000074 Low-spin heme (heme b) binding site [chemical binding]; other site 882097000075 Putative water exit pathway; other site 882097000076 Binuclear center (heme o3/CuB) [ion binding]; other site 882097000077 K-pathway; other site 882097000078 Putative proton exit pathway; other site 882097000079 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 882097000080 Subunit I/III interface [polypeptide binding]; other site 882097000081 Subunit III/IV interface [polypeptide binding]; other site 882097000082 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 882097000083 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 882097000084 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 882097000085 putative active site [active] 882097000086 putative metal binding site [ion binding]; other site 882097000087 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 882097000088 beta-galactosidase; Region: BGL; TIGR03356 882097000089 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 882097000090 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 882097000091 active site flap/lid [active] 882097000092 nucleophilic elbow; other site 882097000093 catalytic triad [active] 882097000094 Peptidase M16C associated; Region: M16C_assoc; pfam08367 882097000095 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 882097000096 Bacterial SH3 domain; Region: SH3_3; pfam08239 882097000097 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 882097000098 putative active site [active] 882097000099 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882097000100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097000101 DNA-binding site [nucleotide binding]; DNA binding site 882097000102 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 882097000103 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882097000104 active site 882097000105 active pocket/dimerization site; other site 882097000106 phosphorylation site [posttranslational modification] 882097000107 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 882097000108 active site 882097000109 phosphorylation site [posttranslational modification] 882097000110 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 882097000111 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 882097000112 hypothetical protein; Provisional; Region: PRK02947 882097000113 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882097000114 putative active site [active] 882097000115 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 882097000116 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 882097000117 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882097000118 active site turn [active] 882097000119 phosphorylation site [posttranslational modification] 882097000120 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882097000121 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 882097000122 HPr interaction site; other site 882097000123 glycerol kinase (GK) interaction site [polypeptide binding]; other site 882097000124 active site 882097000125 phosphorylation site [posttranslational modification] 882097000126 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 882097000127 putative dimer interface [polypeptide binding]; other site 882097000128 catalytic triad [active] 882097000129 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882097000130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097000131 active site 882097000132 motif I; other site 882097000133 motif II; other site 882097000134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097000135 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882097000136 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882097000137 DNA binding site [nucleotide binding] 882097000138 domain linker motif; other site 882097000139 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 882097000140 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882097000141 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882097000142 nucleotide binding site [chemical binding]; other site 882097000143 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 882097000144 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882097000145 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882097000146 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 882097000147 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 882097000148 dimer interface [polypeptide binding]; other site 882097000149 active site 882097000150 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 882097000151 dimer interface [polypeptide binding]; other site 882097000152 active site 882097000153 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 882097000154 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 882097000155 arginine deiminase; Provisional; Region: PRK01388 882097000156 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 882097000157 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 882097000158 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 882097000159 dimer interface [polypeptide binding]; other site 882097000160 ssDNA binding site [nucleotide binding]; other site 882097000161 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882097000162 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 882097000163 Predicted membrane protein [Function unknown]; Region: COG3212 882097000164 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 882097000165 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 882097000166 putative accessory gene regulator protein; Provisional; Region: PRK01100 882097000167 Staphylococcal AgrD protein; Region: AgrD; cl05477 882097000168 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 882097000169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097000170 ATP binding site [chemical binding]; other site 882097000171 Mg2+ binding site [ion binding]; other site 882097000172 G-X-G motif; other site 882097000173 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 882097000174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097000175 active site 882097000176 phosphorylation site [posttranslational modification] 882097000177 intermolecular recognition site; other site 882097000178 dimerization interface [polypeptide binding]; other site 882097000179 LytTr DNA-binding domain; Region: LytTR; pfam04397 882097000180 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 882097000181 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 882097000182 DHH family; Region: DHH; pfam01368 882097000183 DHHA1 domain; Region: DHHA1; pfam02272 882097000184 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 882097000185 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 882097000186 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 882097000187 replicative DNA helicase; Provisional; Region: PRK05748 882097000188 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 882097000189 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 882097000190 Walker A motif; other site 882097000191 ATP binding site [chemical binding]; other site 882097000192 Walker B motif; other site 882097000193 DNA binding loops [nucleotide binding] 882097000194 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 882097000195 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 882097000196 GDP-binding site [chemical binding]; other site 882097000197 ACT binding site; other site 882097000198 IMP binding site; other site 882097000199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 882097000200 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 882097000201 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 882097000202 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 882097000203 Uncharacterized small protein [Function unknown]; Region: COG5417 882097000204 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 882097000205 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 882097000206 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 882097000207 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 882097000208 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 882097000209 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 882097000210 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 882097000211 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 882097000212 tetramer interface [polypeptide binding]; other site 882097000213 active site 882097000214 Mg2+/Mn2+ binding site [ion binding]; other site 882097000215 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 882097000216 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 882097000217 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 882097000218 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 882097000219 DNA binding site [nucleotide binding] 882097000220 active site 882097000221 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 882097000222 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 882097000223 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 882097000224 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 882097000225 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 882097000226 putative ligand binding site [chemical binding]; other site 882097000227 putative NAD binding site [chemical binding]; other site 882097000228 catalytic site [active] 882097000229 LXG domain of WXG superfamily; Region: LXG; pfam04740 882097000230 TM2 domain; Region: TM2; pfam05154 882097000231 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882097000232 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882097000233 DNA binding residues [nucleotide binding] 882097000234 putative dimer interface [polypeptide binding]; other site 882097000235 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882097000236 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882097000237 active site 882097000238 catalytic tetrad [active] 882097000239 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097000240 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 882097000241 ATP synthase subunit C; Region: ATP-synt_C; cl00466 882097000242 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 882097000243 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 882097000244 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 882097000245 Walker A motif; other site 882097000246 ATP binding site [chemical binding]; other site 882097000247 Walker B motif; other site 882097000248 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 882097000249 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 882097000250 core domain interface [polypeptide binding]; other site 882097000251 delta subunit interface [polypeptide binding]; other site 882097000252 epsilon subunit interface [polypeptide binding]; other site 882097000253 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 882097000254 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 882097000255 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 882097000256 alpha subunit interaction interface [polypeptide binding]; other site 882097000257 Walker A motif; other site 882097000258 ATP binding site [chemical binding]; other site 882097000259 Walker B motif; other site 882097000260 inhibitor binding site; inhibition site 882097000261 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 882097000262 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 882097000263 gamma subunit interface [polypeptide binding]; other site 882097000264 epsilon subunit interface [polypeptide binding]; other site 882097000265 LBP interface [polypeptide binding]; other site 882097000266 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882097000267 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882097000268 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882097000269 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882097000270 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882097000271 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882097000272 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882097000273 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097000274 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 882097000275 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882097000276 active pocket/dimerization site; other site 882097000277 active site 882097000278 phosphorylation site [posttranslational modification] 882097000279 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 882097000280 active site 882097000281 phosphorylation site [posttranslational modification] 882097000282 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 882097000283 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 882097000284 Domain of unknown function (DUF956); Region: DUF956; pfam06115 882097000285 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 882097000286 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 882097000287 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 882097000288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882097000289 dimerization interface [polypeptide binding]; other site 882097000290 putative DNA binding site [nucleotide binding]; other site 882097000291 Uncharacterized conserved protein [Function unknown]; Region: COG1359 882097000292 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 882097000293 dimer interface [polypeptide binding]; other site 882097000294 FMN binding site [chemical binding]; other site 882097000295 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 882097000296 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 882097000297 active site 882097000298 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 882097000299 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 882097000300 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 882097000301 aromatic chitin/cellulose binding site residues [chemical binding]; other site 882097000302 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882097000303 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882097000304 nucleotide binding site [chemical binding]; other site 882097000305 butyrate kinase; Region: butyr_kinase; TIGR02707 882097000306 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882097000307 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882097000308 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 882097000309 Walker A/P-loop; other site 882097000310 ATP binding site [chemical binding]; other site 882097000311 Q-loop/lid; other site 882097000312 ABC transporter signature motif; other site 882097000313 Walker B; other site 882097000314 D-loop; other site 882097000315 H-loop/switch region; other site 882097000316 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882097000317 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882097000318 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 882097000319 Walker A/P-loop; other site 882097000320 ATP binding site [chemical binding]; other site 882097000321 Q-loop/lid; other site 882097000322 ABC transporter signature motif; other site 882097000323 Walker B; other site 882097000324 D-loop; other site 882097000325 H-loop/switch region; other site 882097000326 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 882097000327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882097000328 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882097000329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882097000330 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 882097000331 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 882097000332 substrate binding pocket [chemical binding]; other site 882097000333 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 882097000334 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097000335 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 882097000336 ligand binding site [chemical binding]; other site 882097000337 flexible hinge region; other site 882097000338 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882097000339 Domain of unknown function (DUF955); Region: DUF955; pfam06114 882097000340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097000341 non-specific DNA binding site [nucleotide binding]; other site 882097000342 salt bridge; other site 882097000343 sequence-specific DNA binding site [nucleotide binding]; other site 882097000344 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 882097000345 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 882097000346 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 882097000347 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 882097000348 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 882097000349 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 882097000350 putative active site [active] 882097000351 putative metal binding site [ion binding]; other site 882097000352 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 882097000353 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 882097000354 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 882097000355 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 882097000356 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 882097000357 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 882097000358 active site 882097000359 Uncharacterized conserved protein [Function unknown]; Region: COG3592 882097000360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097000361 Coenzyme A binding pocket [chemical binding]; other site 882097000362 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 882097000363 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 882097000364 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 882097000365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097000366 dimer interface [polypeptide binding]; other site 882097000367 conserved gate region; other site 882097000368 putative PBP binding loops; other site 882097000369 ABC-ATPase subunit interface; other site 882097000370 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 882097000371 dipeptide transporter; Provisional; Region: PRK10913 882097000372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097000373 dimer interface [polypeptide binding]; other site 882097000374 conserved gate region; other site 882097000375 putative PBP binding loops; other site 882097000376 ABC-ATPase subunit interface; other site 882097000377 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 882097000378 LXG domain of WXG superfamily; Region: LXG; pfam04740 882097000379 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 882097000380 NAD binding site [chemical binding]; other site 882097000381 phosphoenolpyruvate synthase; Validated; Region: PRK06464 882097000382 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 882097000383 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 882097000384 peptide binding site [polypeptide binding]; other site 882097000385 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 882097000386 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 882097000387 metal binding site [ion binding]; metal-binding site 882097000388 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 882097000389 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 882097000390 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 882097000391 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882097000392 ABC-ATPase subunit interface; other site 882097000393 dimer interface [polypeptide binding]; other site 882097000394 putative PBP binding regions; other site 882097000395 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097000396 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882097000397 ligand binding site [chemical binding]; other site 882097000398 flexible hinge region; other site 882097000399 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 882097000400 DEAD_2; Region: DEAD_2; pfam06733 882097000401 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 882097000402 sugar phosphate phosphatase; Provisional; Region: PRK10513 882097000403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097000404 active site 882097000405 motif I; other site 882097000406 motif II; other site 882097000407 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097000408 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 882097000409 Collagen binding domain; Region: Collagen_bind; pfam05737 882097000410 Cna protein B-type domain; Region: Cna_B; pfam05738 882097000411 Cna protein B-type domain; Region: Cna_B; pfam05738 882097000412 Cna protein B-type domain; Region: Cna_B; pfam05738 882097000413 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 882097000414 Collagen binding domain; Region: Collagen_bind; pfam05737 882097000415 Cna protein B-type domain; Region: Cna_B; pfam05738 882097000416 Cna protein B-type domain; Region: Cna_B; pfam05738 882097000417 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882097000418 DNA polymerase III subunit delta'; Validated; Region: PRK08058 882097000419 DNA polymerase III subunit delta'; Validated; Region: PRK08485 882097000420 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 882097000421 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 882097000422 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 882097000423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097000424 S-adenosylmethionine binding site [chemical binding]; other site 882097000425 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 882097000426 GIY-YIG motif/motif A; other site 882097000427 putative active site [active] 882097000428 putative metal binding site [ion binding]; other site 882097000429 Predicted methyltransferases [General function prediction only]; Region: COG0313 882097000430 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 882097000431 putative SAM binding site [chemical binding]; other site 882097000432 putative homodimer interface [polypeptide binding]; other site 882097000433 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 882097000434 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 882097000435 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 882097000436 Uncharacterized conserved protein [Function unknown]; Region: COG5361 882097000437 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 882097000438 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 882097000439 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097000440 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 882097000441 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 882097000442 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 882097000443 active site 882097000444 HIGH motif; other site 882097000445 KMSKS motif; other site 882097000446 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 882097000447 tRNA binding surface [nucleotide binding]; other site 882097000448 anticodon binding site; other site 882097000449 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 882097000450 dimer interface [polypeptide binding]; other site 882097000451 putative tRNA-binding site [nucleotide binding]; other site 882097000452 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 882097000453 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882097000454 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882097000455 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 882097000456 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 882097000457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097000458 dimer interface [polypeptide binding]; other site 882097000459 conserved gate region; other site 882097000460 putative PBP binding loops; other site 882097000461 ABC-ATPase subunit interface; other site 882097000462 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882097000463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097000464 dimer interface [polypeptide binding]; other site 882097000465 conserved gate region; other site 882097000466 putative PBP binding loops; other site 882097000467 ABC-ATPase subunit interface; other site 882097000468 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 882097000469 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882097000470 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 882097000471 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 882097000472 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 882097000473 active site 882097000474 catalytic site [active] 882097000475 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 882097000476 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 882097000477 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 882097000478 trimer interface [polypeptide binding]; other site 882097000479 active site 882097000480 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 882097000481 catalytic site [active] 882097000482 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 882097000483 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 882097000484 Ca binding site [ion binding]; other site 882097000485 active site 882097000486 catalytic site [active] 882097000487 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 882097000488 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 882097000489 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 882097000490 active site 882097000491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 882097000492 Domain of unknown function (DUF348); Region: DUF348; pfam03990 882097000493 Domain of unknown function (DUF348); Region: DUF348; pfam03990 882097000494 G5 domain; Region: G5; pfam07501 882097000495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 882097000496 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 882097000497 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 882097000498 putative active site [active] 882097000499 putative metal binding site [ion binding]; other site 882097000500 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 882097000501 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 882097000502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097000503 S-adenosylmethionine binding site [chemical binding]; other site 882097000504 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 882097000505 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 882097000506 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 882097000507 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 882097000508 putative active site [active] 882097000509 YdjC motif; other site 882097000510 Mg binding site [ion binding]; other site 882097000511 putative homodimer interface [polypeptide binding]; other site 882097000512 pur operon repressor; Provisional; Region: PRK09213 882097000513 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 882097000514 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882097000515 active site 882097000516 HlyD family secretion protein; Region: HlyD_3; pfam13437 882097000517 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882097000518 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882097000519 Walker A/P-loop; other site 882097000520 ATP binding site [chemical binding]; other site 882097000521 Q-loop/lid; other site 882097000522 ABC transporter signature motif; other site 882097000523 Walker B; other site 882097000524 D-loop; other site 882097000525 H-loop/switch region; other site 882097000526 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882097000527 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882097000528 FtsX-like permease family; Region: FtsX; pfam02687 882097000529 regulatory protein SpoVG; Reviewed; Region: PRK13259 882097000530 regulatory protein SpoVG; Reviewed; Region: PRK13259 882097000531 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 882097000532 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 882097000533 Substrate binding site; other site 882097000534 Mg++ binding site; other site 882097000535 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 882097000536 active site 882097000537 substrate binding site [chemical binding]; other site 882097000538 CoA binding site [chemical binding]; other site 882097000539 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 882097000540 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 882097000541 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882097000542 active site 882097000543 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097000544 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882097000545 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882097000546 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 882097000547 active site 882097000548 catalytic site [active] 882097000549 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 882097000550 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 882097000551 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 882097000552 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 882097000553 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 882097000554 active site 882097000555 Zn binding site [ion binding]; other site 882097000556 ActA Protein; Region: ActA; pfam05058 882097000557 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 882097000558 Zn binding site [ion binding]; other site 882097000559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 882097000560 hypothetical protein; Provisional; Region: PRK01119 882097000561 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 882097000562 A new structural DNA glycosylase; Region: AlkD_like; cd06561 882097000563 active site 882097000564 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 882097000565 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 882097000566 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882097000567 NAD binding site [chemical binding]; other site 882097000568 dimer interface [polypeptide binding]; other site 882097000569 substrate binding site [chemical binding]; other site 882097000570 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 882097000571 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 882097000572 5S rRNA interface [nucleotide binding]; other site 882097000573 CTC domain interface [polypeptide binding]; other site 882097000574 L16 interface [polypeptide binding]; other site 882097000575 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882097000576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097000577 Coenzyme A binding pocket [chemical binding]; other site 882097000578 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 882097000579 putative active site [active] 882097000580 catalytic residue [active] 882097000581 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 882097000582 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 882097000583 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882097000584 ATP binding site [chemical binding]; other site 882097000585 putative Mg++ binding site [ion binding]; other site 882097000586 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882097000587 nucleotide binding region [chemical binding]; other site 882097000588 ATP-binding site [chemical binding]; other site 882097000589 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 882097000590 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 882097000591 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 882097000592 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882097000593 RNA binding surface [nucleotide binding]; other site 882097000594 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 882097000595 Septum formation initiator; Region: DivIC; pfam04977 882097000596 hypothetical protein; Provisional; Region: PRK08582 882097000597 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 882097000598 RNA binding site [nucleotide binding]; other site 882097000599 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 882097000600 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 882097000601 Ligand Binding Site [chemical binding]; other site 882097000602 TilS substrate C-terminal domain; Region: TilS_C; smart00977 882097000603 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 882097000604 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882097000605 active site 882097000606 FtsH Extracellular; Region: FtsH_ext; pfam06480 882097000607 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 882097000608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097000609 Walker A motif; other site 882097000610 ATP binding site [chemical binding]; other site 882097000611 Walker B motif; other site 882097000612 arginine finger; other site 882097000613 Peptidase family M41; Region: Peptidase_M41; pfam01434 882097000614 pantothenate kinase; Reviewed; Region: PRK13318 882097000615 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 882097000616 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 882097000617 dimerization interface [polypeptide binding]; other site 882097000618 domain crossover interface; other site 882097000619 redox-dependent activation switch; other site 882097000620 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 882097000621 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 882097000622 dimer interface [polypeptide binding]; other site 882097000623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097000624 catalytic residue [active] 882097000625 dihydropteroate synthase; Region: DHPS; TIGR01496 882097000626 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 882097000627 substrate binding pocket [chemical binding]; other site 882097000628 dimer interface [polypeptide binding]; other site 882097000629 inhibitor binding site; inhibition site 882097000630 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 882097000631 homooctamer interface [polypeptide binding]; other site 882097000632 active site 882097000633 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 882097000634 catalytic center binding site [active] 882097000635 ATP binding site [chemical binding]; other site 882097000636 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 882097000637 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 882097000638 FMN binding site [chemical binding]; other site 882097000639 active site 882097000640 catalytic residues [active] 882097000641 substrate binding site [chemical binding]; other site 882097000642 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 882097000643 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 882097000644 dimer interface [polypeptide binding]; other site 882097000645 putative anticodon binding site; other site 882097000646 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 882097000647 motif 1; other site 882097000648 active site 882097000649 motif 2; other site 882097000650 motif 3; other site 882097000651 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 882097000652 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 882097000653 UvrB/uvrC motif; Region: UVR; pfam02151 882097000654 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 882097000655 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 882097000656 ADP binding site [chemical binding]; other site 882097000657 phosphagen binding site; other site 882097000658 substrate specificity loop; other site 882097000659 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 882097000660 Clp amino terminal domain; Region: Clp_N; pfam02861 882097000661 Clp amino terminal domain; Region: Clp_N; pfam02861 882097000662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097000663 Walker A motif; other site 882097000664 ATP binding site [chemical binding]; other site 882097000665 Walker B motif; other site 882097000666 arginine finger; other site 882097000667 UvrB/uvrC motif; Region: UVR; pfam02151 882097000668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097000669 Walker A motif; other site 882097000670 ATP binding site [chemical binding]; other site 882097000671 Walker B motif; other site 882097000672 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 882097000673 DNA repair protein RadA; Provisional; Region: PRK11823 882097000674 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 882097000675 Walker A motif/ATP binding site; other site 882097000676 ATP binding site [chemical binding]; other site 882097000677 Walker B motif; other site 882097000678 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 882097000679 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 882097000680 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 882097000681 putative active site [active] 882097000682 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 882097000683 substrate binding site; other site 882097000684 dimer interface; other site 882097000685 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 882097000686 homotrimer interaction site [polypeptide binding]; other site 882097000687 zinc binding site [ion binding]; other site 882097000688 CDP-binding sites; other site 882097000689 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 882097000690 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 882097000691 HIGH motif; other site 882097000692 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 882097000693 active site 882097000694 KMSKS motif; other site 882097000695 serine O-acetyltransferase; Region: cysE; TIGR01172 882097000696 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 882097000697 trimer interface [polypeptide binding]; other site 882097000698 active site 882097000699 substrate binding site [chemical binding]; other site 882097000700 CoA binding site [chemical binding]; other site 882097000701 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 882097000702 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 882097000703 active site 882097000704 HIGH motif; other site 882097000705 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 882097000706 KMSKS motif; other site 882097000707 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 882097000708 tRNA binding surface [nucleotide binding]; other site 882097000709 anticodon binding site; other site 882097000710 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 882097000711 active site 882097000712 metal binding site [ion binding]; metal-binding site 882097000713 dimerization interface [polypeptide binding]; other site 882097000714 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 882097000715 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 882097000716 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 882097000717 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 882097000718 RNA polymerase factor sigma-70; Validated; Region: PRK08295 882097000719 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 882097000720 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 882097000721 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 882097000722 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 882097000723 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 882097000724 putative homodimer interface [polypeptide binding]; other site 882097000725 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 882097000726 heterodimer interface [polypeptide binding]; other site 882097000727 homodimer interface [polypeptide binding]; other site 882097000728 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 882097000729 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 882097000730 23S rRNA interface [nucleotide binding]; other site 882097000731 L7/L12 interface [polypeptide binding]; other site 882097000732 putative thiostrepton binding site; other site 882097000733 L25 interface [polypeptide binding]; other site 882097000734 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 882097000735 mRNA/rRNA interface [nucleotide binding]; other site 882097000736 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 882097000737 23S rRNA interface [nucleotide binding]; other site 882097000738 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 882097000739 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 882097000740 core dimer interface [polypeptide binding]; other site 882097000741 peripheral dimer interface [polypeptide binding]; other site 882097000742 L10 interface [polypeptide binding]; other site 882097000743 L11 interface [polypeptide binding]; other site 882097000744 putative EF-Tu interaction site [polypeptide binding]; other site 882097000745 putative EF-G interaction site [polypeptide binding]; other site 882097000746 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 882097000747 Penicillinase repressor; Region: Pencillinase_R; pfam03965 882097000748 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 882097000749 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 882097000750 Protein of unknown function (DUF1307); Region: DUF1307; pfam06998 882097000751 Methyltransferase domain; Region: Methyltransf_31; pfam13847 882097000752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097000753 S-adenosylmethionine binding site [chemical binding]; other site 882097000754 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 882097000755 Protein of unknown function (DUF2947); Region: DUF2947; pfam11163 882097000756 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 882097000757 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 882097000758 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 882097000759 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 882097000760 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 882097000761 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 882097000762 RPB10 interaction site [polypeptide binding]; other site 882097000763 RPB1 interaction site [polypeptide binding]; other site 882097000764 RPB11 interaction site [polypeptide binding]; other site 882097000765 RPB3 interaction site [polypeptide binding]; other site 882097000766 RPB12 interaction site [polypeptide binding]; other site 882097000767 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 882097000768 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 882097000769 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 882097000770 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 882097000771 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 882097000772 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 882097000773 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 882097000774 G-loop; other site 882097000775 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 882097000776 DNA binding site [nucleotide binding] 882097000777 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 882097000778 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 882097000779 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097000780 active site 882097000781 motif I; other site 882097000782 motif II; other site 882097000783 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882097000784 beta-galactosidase; Region: BGL; TIGR03356 882097000785 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882097000786 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882097000787 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000788 Substrate binding site [chemical binding]; other site 882097000789 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000790 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000791 LRR adjacent; Region: LRR_adjacent; pfam08191 882097000792 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097000793 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097000794 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882097000795 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882097000796 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000797 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000798 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000799 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000800 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000801 LRR adjacent; Region: LRR_adjacent; pfam08191 882097000802 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097000803 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097000804 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882097000805 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882097000806 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000807 Substrate binding site [chemical binding]; other site 882097000808 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000809 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000810 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000811 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000812 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000813 LRR adjacent; Region: LRR_adjacent; pfam08191 882097000814 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097000815 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097000816 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882097000817 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000818 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882097000819 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000820 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000821 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000822 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097000823 LRR adjacent; Region: LRR_adjacent; pfam08191 882097000824 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097000825 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882097000826 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 882097000827 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 882097000828 metal binding site [ion binding]; metal-binding site 882097000829 dimer interface [polypeptide binding]; other site 882097000830 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882097000831 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882097000832 LRR adjacent; Region: LRR_adjacent; pfam08191 882097000833 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097000834 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882097000835 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882097000836 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882097000837 putative Zn2+ binding site [ion binding]; other site 882097000838 putative DNA binding site [nucleotide binding]; other site 882097000839 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 882097000840 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882097000841 Zn binding site [ion binding]; other site 882097000842 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 882097000843 Zn binding site [ion binding]; other site 882097000844 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882097000845 catalytic core [active] 882097000846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 882097000847 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 882097000848 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 882097000849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097000850 dimer interface [polypeptide binding]; other site 882097000851 conserved gate region; other site 882097000852 ABC-ATPase subunit interface; other site 882097000853 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882097000854 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882097000855 Leucine-rich repeats; other site 882097000856 Substrate binding site [chemical binding]; other site 882097000857 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 882097000858 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882097000859 beta-galactosidase; Region: BGL; TIGR03356 882097000860 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 882097000861 sugar phosphate phosphatase; Provisional; Region: PRK10513 882097000862 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097000863 active site 882097000864 motif I; other site 882097000865 motif II; other site 882097000866 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097000867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097000868 Coenzyme A binding pocket [chemical binding]; other site 882097000869 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097000870 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882097000871 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 882097000872 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 882097000873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097000874 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 882097000875 active site 882097000876 motif I; other site 882097000877 motif II; other site 882097000878 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097000879 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882097000880 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882097000881 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 882097000882 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 882097000883 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 882097000884 Walker A/P-loop; other site 882097000885 ATP binding site [chemical binding]; other site 882097000886 Q-loop/lid; other site 882097000887 ABC transporter signature motif; other site 882097000888 Walker B; other site 882097000889 D-loop; other site 882097000890 H-loop/switch region; other site 882097000891 TOBE domain; Region: TOBE; pfam03459 882097000892 ATP cone domain; Region: ATP-cone; pfam03477 882097000893 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 882097000894 Class III ribonucleotide reductase; Region: RNR_III; cd01675 882097000895 effector binding site; other site 882097000896 active site 882097000897 Zn binding site [ion binding]; other site 882097000898 glycine loop; other site 882097000899 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 882097000900 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 882097000901 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 882097000902 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097000903 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882097000904 Predicted amidohydrolase [General function prediction only]; Region: COG0388 882097000905 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 882097000906 putative active site [active] 882097000907 catalytic triad [active] 882097000908 putative dimer interface [polypeptide binding]; other site 882097000909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097000910 dimer interface [polypeptide binding]; other site 882097000911 conserved gate region; other site 882097000912 ABC-ATPase subunit interface; other site 882097000913 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 882097000914 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 882097000915 Walker A/P-loop; other site 882097000916 ATP binding site [chemical binding]; other site 882097000917 Q-loop/lid; other site 882097000918 ABC transporter signature motif; other site 882097000919 Walker B; other site 882097000920 D-loop; other site 882097000921 H-loop/switch region; other site 882097000922 NIL domain; Region: NIL; pfam09383 882097000923 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 882097000924 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 882097000925 transaminase; Reviewed; Region: PRK08068 882097000926 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882097000927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097000928 homodimer interface [polypeptide binding]; other site 882097000929 catalytic residue [active] 882097000930 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882097000931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097000932 active site 882097000933 phosphorylation site [posttranslational modification] 882097000934 intermolecular recognition site; other site 882097000935 dimerization interface [polypeptide binding]; other site 882097000936 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882097000937 DNA binding site [nucleotide binding] 882097000938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 882097000939 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882097000940 dimerization interface [polypeptide binding]; other site 882097000941 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 882097000942 putative active site [active] 882097000943 heme pocket [chemical binding]; other site 882097000944 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882097000945 dimer interface [polypeptide binding]; other site 882097000946 phosphorylation site [posttranslational modification] 882097000947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097000948 ATP binding site [chemical binding]; other site 882097000949 Mg2+ binding site [ion binding]; other site 882097000950 G-X-G motif; other site 882097000951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 882097000952 YycH protein; Region: YycH; pfam07435 882097000953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 882097000954 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 882097000955 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 882097000956 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 882097000957 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 882097000958 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 882097000959 protein binding site [polypeptide binding]; other site 882097000960 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 882097000961 Transglycosylase; Region: Transgly; cl17702 882097000962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097000963 Coenzyme A binding pocket [chemical binding]; other site 882097000964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882097000965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882097000966 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 882097000967 dimerization interface [polypeptide binding]; other site 882097000968 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882097000969 HTH domain; Region: HTH_11; pfam08279 882097000970 Mga helix-turn-helix domain; Region: Mga; pfam05043 882097000971 PRD domain; Region: PRD; pfam00874 882097000972 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882097000973 active site 882097000974 P-loop; other site 882097000975 phosphorylation site [posttranslational modification] 882097000976 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097000977 active site 882097000978 phosphorylation site [posttranslational modification] 882097000979 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882097000980 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882097000981 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882097000982 active site 882097000983 P-loop; other site 882097000984 phosphorylation site [posttranslational modification] 882097000985 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882097000986 beta-galactosidase; Region: BGL; TIGR03356 882097000987 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882097000988 methionine cluster; other site 882097000989 active site 882097000990 phosphorylation site [posttranslational modification] 882097000991 metal binding site [ion binding]; metal-binding site 882097000992 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 882097000993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882097000994 ATP binding site [chemical binding]; other site 882097000995 AAA domain; Region: AAA_30; pfam13604 882097000996 AAA domain; Region: AAA_12; pfam13087 882097000997 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 882097000998 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 882097000999 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 882097001000 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 882097001001 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882097001002 catalytic residue [active] 882097001003 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 882097001004 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 882097001005 nucleophilic elbow; other site 882097001006 catalytic triad; other site 882097001007 Uncharacterized conserved protein [Function unknown]; Region: COG1479 882097001008 Protein of unknown function DUF262; Region: DUF262; pfam03235 882097001009 Protein of unknown function DUF262; Region: DUF262; pfam03235 882097001010 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 882097001011 NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521 882097001012 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 882097001013 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 882097001014 cofactor binding site; other site 882097001015 DNA binding site [nucleotide binding] 882097001016 substrate interaction site [chemical binding]; other site 882097001017 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 882097001018 putative active site [active] 882097001019 YdjC motif; other site 882097001020 Mg binding site [ion binding]; other site 882097001021 putative homodimer interface [polypeptide binding]; other site 882097001022 Putative transcription activator [Transcription]; Region: TenA; COG0819 882097001023 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 882097001024 substrate binding site [chemical binding]; other site 882097001025 multimerization interface [polypeptide binding]; other site 882097001026 ATP binding site [chemical binding]; other site 882097001027 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 882097001028 dimer interface [polypeptide binding]; other site 882097001029 substrate binding site [chemical binding]; other site 882097001030 ATP binding site [chemical binding]; other site 882097001031 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 882097001032 thiamine phosphate binding site [chemical binding]; other site 882097001033 active site 882097001034 pyrophosphate binding site [ion binding]; other site 882097001035 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882097001036 beta-galactosidase; Region: BGL; TIGR03356 882097001037 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 882097001038 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 882097001039 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 882097001040 putative catalytic site [active] 882097001041 putative metal binding site [ion binding]; other site 882097001042 putative phosphate binding site [ion binding]; other site 882097001043 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097001044 non-specific DNA binding site [nucleotide binding]; other site 882097001045 salt bridge; other site 882097001046 sequence-specific DNA binding site [nucleotide binding]; other site 882097001047 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 882097001048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097001049 non-specific DNA binding site [nucleotide binding]; other site 882097001050 salt bridge; other site 882097001051 sequence-specific DNA binding site [nucleotide binding]; other site 882097001052 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 882097001053 Leucine rich repeat; Region: LRR_8; pfam13855 882097001054 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001055 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001056 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001057 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001058 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001059 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001060 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001061 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001062 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001063 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001064 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001065 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001066 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001067 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001068 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097001069 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097001070 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882097001071 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097001072 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882097001073 Leucine-rich repeats; other site 882097001074 Substrate binding site [chemical binding]; other site 882097001075 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097001076 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097001077 Leucine rich repeat; Region: LRR_8; pfam13855 882097001078 Leucine rich repeat; Region: LRR_8; pfam13855 882097001079 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097001080 Leucine rich repeat; Region: LRR_8; pfam13855 882097001081 Leucine rich repeat; Region: LRR_8; pfam13855 882097001082 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097001083 LRR adjacent; Region: LRR_adjacent; pfam08191 882097001084 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001085 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001086 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001087 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 882097001088 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 882097001089 LXG domain of WXG superfamily; Region: LXG; pfam04740 882097001090 LXG domain of WXG superfamily; Region: LXG; pfam04740 882097001091 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 882097001092 Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221 882097001093 Enterocin A Immunity; Region: EntA_Immun; pfam08951 882097001094 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 882097001095 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 882097001096 TPP-binding site [chemical binding]; other site 882097001097 dimer interface [polypeptide binding]; other site 882097001098 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 882097001099 PYR/PP interface [polypeptide binding]; other site 882097001100 dimer interface [polypeptide binding]; other site 882097001101 TPP binding site [chemical binding]; other site 882097001102 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882097001103 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 882097001104 active site 882097001105 intersubunit interactions; other site 882097001106 catalytic residue [active] 882097001107 short chain dehydrogenase; Provisional; Region: PRK06841 882097001108 classical (c) SDRs; Region: SDR_c; cd05233 882097001109 NAD(P) binding site [chemical binding]; other site 882097001110 active site 882097001111 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 882097001112 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 882097001113 substrate binding site [chemical binding]; other site 882097001114 dimer interface [polypeptide binding]; other site 882097001115 catalytic triad [active] 882097001116 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 882097001117 DAK2 domain; Region: Dak2; cl03685 882097001118 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 882097001119 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 882097001120 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 882097001121 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882097001122 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882097001123 putative DNA binding site [nucleotide binding]; other site 882097001124 putative Zn2+ binding site [ion binding]; other site 882097001125 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882097001126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097001127 Coenzyme A binding pocket [chemical binding]; other site 882097001128 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882097001129 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882097001130 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882097001131 Leucine-rich repeats; other site 882097001132 LRR adjacent; Region: LRR_adjacent; pfam08191 882097001133 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097001134 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097001135 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 882097001136 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 882097001137 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 882097001138 acyl-activating enzyme (AAE) consensus motif; other site 882097001139 acyl-activating enzyme (AAE) consensus motif; other site 882097001140 AMP binding site [chemical binding]; other site 882097001141 active site 882097001142 CoA binding site [chemical binding]; other site 882097001143 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 882097001144 L-aspartate oxidase; Provisional; Region: PRK06175 882097001145 putative oxidoreductase; Provisional; Region: PRK10206 882097001146 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882097001147 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 882097001148 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097001149 active site 882097001150 phosphorylation site [posttranslational modification] 882097001151 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 882097001152 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882097001153 active site 882097001154 P-loop; other site 882097001155 phosphorylation site [posttranslational modification] 882097001156 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882097001157 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 882097001158 intersubunit interface [polypeptide binding]; other site 882097001159 active site 882097001160 zinc binding site [ion binding]; other site 882097001161 Na+ binding site [ion binding]; other site 882097001162 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882097001163 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 882097001164 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882097001165 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 882097001166 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 882097001167 Peptidase E [Amino acid transport and metabolism]; Region: PepE; COG3340 882097001168 conserved cys residue [active] 882097001169 Predicted transcriptional regulator [Transcription]; Region: COG2378 882097001170 HTH domain; Region: HTH_11; pfam08279 882097001171 WYL domain; Region: WYL; pfam13280 882097001172 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 882097001173 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 882097001174 Imelysin; Region: Peptidase_M75; pfam09375 882097001175 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 882097001176 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 882097001177 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 882097001178 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 882097001179 nudix motif; other site 882097001180 hypothetical protein; Provisional; Region: PRK12378 882097001181 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 882097001182 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 882097001183 PhnA protein; Region: PhnA; pfam03831 882097001184 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882097001185 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097001186 DNA-binding site [nucleotide binding]; DNA binding site 882097001187 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 882097001188 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882097001189 beta-galactosidase; Region: BGL; TIGR03356 882097001190 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882097001191 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 882097001192 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882097001193 active site 882097001194 P-loop; other site 882097001195 phosphorylation site [posttranslational modification] 882097001196 Predicted transcriptional regulator [Transcription]; Region: COG2378 882097001197 HTH domain; Region: HTH_11; pfam08279 882097001198 WYL domain; Region: WYL; pfam13280 882097001199 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 882097001200 LXG domain of WXG superfamily; Region: LXG; pfam04740 882097001201 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882097001202 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 882097001203 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882097001204 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 882097001205 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 882097001206 tetrameric interface [polypeptide binding]; other site 882097001207 NAD binding site [chemical binding]; other site 882097001208 catalytic residues [active] 882097001209 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 882097001210 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 882097001211 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 882097001212 substrate binding site [chemical binding]; other site 882097001213 ATP binding site [chemical binding]; other site 882097001214 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 882097001215 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 882097001216 PYR/PP interface [polypeptide binding]; other site 882097001217 dimer interface [polypeptide binding]; other site 882097001218 TPP binding site [chemical binding]; other site 882097001219 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 882097001220 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 882097001221 TPP-binding site; other site 882097001222 Uncharacterized conserved protein [Function unknown]; Region: COG5646 882097001223 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 882097001224 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 882097001225 ligand binding site [chemical binding]; other site 882097001226 active site 882097001227 UGI interface [polypeptide binding]; other site 882097001228 catalytic site [active] 882097001229 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 882097001230 hypothetical protein; Provisional; Region: PRK13665 882097001231 Bacterial SH3 domain; Region: SH3_3; cl17532 882097001232 NlpC/P60 family; Region: NLPC_P60; pfam00877 882097001233 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882097001234 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097001235 Coenzyme A binding pocket [chemical binding]; other site 882097001236 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 882097001237 pyrroline-5-carboxylate reductase; Region: PLN02688 882097001238 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882097001239 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882097001240 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882097001241 Transcriptional regulators [Transcription]; Region: GntR; COG1802 882097001242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097001243 DNA-binding site [nucleotide binding]; DNA binding site 882097001244 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 882097001245 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882097001246 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882097001247 Walker A/P-loop; other site 882097001248 ATP binding site [chemical binding]; other site 882097001249 Q-loop/lid; other site 882097001250 ABC transporter signature motif; other site 882097001251 Walker B; other site 882097001252 D-loop; other site 882097001253 H-loop/switch region; other site 882097001254 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882097001255 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882097001256 FtsX-like permease family; Region: FtsX; pfam02687 882097001257 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 882097001258 putative hydrophobic ligand binding site [chemical binding]; other site 882097001259 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097001260 active site 882097001261 phosphorylation site [posttranslational modification] 882097001262 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882097001263 active site 882097001264 P-loop; other site 882097001265 phosphorylation site [posttranslational modification] 882097001266 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882097001267 alpha-mannosidase; Provisional; Region: PRK09819 882097001268 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 882097001269 active site 882097001270 metal binding site [ion binding]; metal-binding site 882097001271 catalytic site [active] 882097001272 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 882097001273 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882097001274 HTH domain; Region: HTH_11; pfam08279 882097001275 Mga helix-turn-helix domain; Region: Mga; pfam05043 882097001276 PRD domain; Region: PRD; pfam00874 882097001277 PRD domain; Region: PRD; pfam00874 882097001278 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882097001279 active site 882097001280 P-loop; other site 882097001281 phosphorylation site [posttranslational modification] 882097001282 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097001283 active site 882097001284 phosphorylation site [posttranslational modification] 882097001285 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 882097001286 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 882097001287 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882097001288 putative metal binding site [ion binding]; other site 882097001289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 882097001290 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 882097001291 trimer interface [polypeptide binding]; other site 882097001292 phosphoenolpyruvate synthase; Validated; Region: PRK06241 882097001293 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 882097001294 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 882097001295 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 882097001296 ZIP Zinc transporter; Region: Zip; pfam02535 882097001297 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 882097001298 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 882097001299 NodB motif; other site 882097001300 active site 882097001301 catalytic site [active] 882097001302 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097001303 salt bridge; other site 882097001304 non-specific DNA binding site [nucleotide binding]; other site 882097001305 sequence-specific DNA binding site [nucleotide binding]; other site 882097001306 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 882097001307 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882097001308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097001309 active site 882097001310 motif I; other site 882097001311 motif II; other site 882097001312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097001313 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 882097001314 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 882097001315 Predicted transcriptional regulators [Transcription]; Region: COG1695 882097001316 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 882097001317 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 882097001318 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 882097001319 DNA binding residues [nucleotide binding] 882097001320 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 882097001321 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882097001322 HTH domain; Region: HTH_11; pfam08279 882097001323 PRD domain; Region: PRD; pfam00874 882097001324 PRD domain; Region: PRD; pfam00874 882097001325 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882097001326 active site 882097001327 P-loop; other site 882097001328 phosphorylation site [posttranslational modification] 882097001329 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097001330 active site 882097001331 phosphorylation site [posttranslational modification] 882097001332 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097001333 active site 882097001334 phosphorylation site [posttranslational modification] 882097001335 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882097001336 active site 882097001337 P-loop; other site 882097001338 phosphorylation site [posttranslational modification] 882097001339 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882097001340 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 882097001341 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 882097001342 active site 882097001343 metal binding site [ion binding]; metal-binding site 882097001344 catalytic site [active] 882097001345 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 882097001346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882097001347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882097001348 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 882097001349 dimerization interface [polypeptide binding]; other site 882097001350 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 882097001351 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 882097001352 active site 882097001353 substrate binding site [chemical binding]; other site 882097001354 trimer interface [polypeptide binding]; other site 882097001355 CoA binding site [chemical binding]; other site 882097001356 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 882097001357 classical (c) SDRs; Region: SDR_c; cd05233 882097001358 NAD(P) binding site [chemical binding]; other site 882097001359 active site 882097001360 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 882097001361 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 882097001362 RHS Repeat; Region: RHS_repeat; pfam05593 882097001363 RHS Repeat; Region: RHS_repeat; pfam05593 882097001364 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 882097001365 RHS Repeat; Region: RHS_repeat; pfam05593 882097001366 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 882097001367 RHS Repeat; Region: RHS_repeat; pfam05593 882097001368 RHS Repeat; Region: RHS_repeat; pfam05593 882097001369 RHS Repeat; Region: RHS_repeat; pfam05593 882097001370 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 882097001371 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882097001372 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882097001373 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882097001374 Substrate binding site [chemical binding]; other site 882097001375 LRR adjacent; Region: LRR_adjacent; pfam08191 882097001376 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097001377 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097001378 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097001379 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 882097001380 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882097001381 Leucine rich repeat; Region: LRR_8; pfam13855 882097001382 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882097001383 Leucine rich repeat; Region: LRR_8; pfam13855 882097001384 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097001385 LRR adjacent; Region: LRR_adjacent; pfam08191 882097001386 Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543 882097001387 SH3-like domain; Region: SH3_8; pfam13457 882097001388 Predicted transcriptional regulator [Transcription]; Region: COG1959 882097001389 Transcriptional regulator; Region: Rrf2; pfam02082 882097001390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 882097001391 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 882097001392 NAD(P) binding site [chemical binding]; other site 882097001393 active site 882097001394 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 882097001395 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 882097001396 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 882097001397 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 882097001398 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 882097001399 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 882097001400 Transcriptional regulator [Transcription]; Region: LytR; COG1316 882097001401 Predicted membrane protein [Function unknown]; Region: COG1511 882097001402 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 882097001403 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 882097001404 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 882097001405 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 882097001406 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 882097001407 Mga helix-turn-helix domain; Region: Mga; pfam05043 882097001408 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 882097001409 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 882097001410 active site 882097001411 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 882097001412 L-tyrosine decarboxylase; Provisional; Region: PRK13520 882097001413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097001414 catalytic residue [active] 882097001415 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 882097001416 Predicted membrane protein [Function unknown]; Region: COG3619 882097001417 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 882097001418 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 882097001419 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 882097001420 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 882097001421 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 882097001422 Protein of unknown function DUF58; Region: DUF58; pfam01882 882097001423 MoxR-like ATPases [General function prediction only]; Region: COG0714 882097001424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097001425 Walker A motif; other site 882097001426 ATP binding site [chemical binding]; other site 882097001427 Walker B motif; other site 882097001428 arginine finger; other site 882097001429 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 882097001430 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 882097001431 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 882097001432 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 882097001433 Na binding site [ion binding]; other site 882097001434 Uncharacterized conserved protein [Function unknown]; Region: COG3535 882097001435 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 882097001436 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882097001437 nucleotide binding site [chemical binding]; other site 882097001438 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 882097001439 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 882097001440 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 882097001441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882097001442 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 882097001443 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 882097001444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 882097001445 FeS/SAM binding site; other site 882097001446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 882097001447 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 882097001448 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 882097001449 putative active site [active] 882097001450 putative NTP binding site [chemical binding]; other site 882097001451 putative nucleic acid binding site [nucleotide binding]; other site 882097001452 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 882097001453 putative FMN binding site [chemical binding]; other site 882097001454 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 882097001455 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 882097001456 nudix motif; other site 882097001457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882097001458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882097001459 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 882097001460 putative dimerization interface [polypeptide binding]; other site 882097001461 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 882097001462 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 882097001463 active site 882097001464 FMN binding site [chemical binding]; other site 882097001465 substrate binding site [chemical binding]; other site 882097001466 putative catalytic residue [active] 882097001467 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 882097001468 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882097001469 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882097001470 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 882097001471 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 882097001472 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 882097001473 shikimate binding site; other site 882097001474 NAD(P) binding site [chemical binding]; other site 882097001475 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 882097001476 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 882097001477 active site 882097001478 catalytic residue [active] 882097001479 dimer interface [polypeptide binding]; other site 882097001480 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 882097001481 active site 882097001482 catalytic triad [active] 882097001483 oxyanion hole [active] 882097001484 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 882097001485 EamA-like transporter family; Region: EamA; pfam00892 882097001486 EamA-like transporter family; Region: EamA; pfam00892 882097001487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 882097001488 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 882097001489 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 882097001490 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 882097001491 substrate binding site [chemical binding]; other site 882097001492 hexamer interface [polypeptide binding]; other site 882097001493 metal binding site [ion binding]; metal-binding site 882097001494 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 882097001495 catalytic residue [active] 882097001496 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882097001497 PRD domain; Region: PRD; pfam00874 882097001498 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882097001499 active site 882097001500 P-loop; other site 882097001501 phosphorylation site [posttranslational modification] 882097001502 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097001503 active site 882097001504 phosphorylation site [posttranslational modification] 882097001505 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 882097001506 putative active site [active] 882097001507 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097001508 active site 882097001509 phosphorylation site [posttranslational modification] 882097001510 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 882097001511 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 882097001512 substrate binding site [chemical binding]; other site 882097001513 hexamer interface [polypeptide binding]; other site 882097001514 metal binding site [ion binding]; metal-binding site 882097001515 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 882097001516 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 882097001517 putative NAD(P) binding site [chemical binding]; other site 882097001518 catalytic Zn binding site [ion binding]; other site 882097001519 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 882097001520 active site 882097001521 P-loop; other site 882097001522 phosphorylation site [posttranslational modification] 882097001523 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 882097001524 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 882097001525 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 882097001526 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 882097001527 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882097001528 active site 882097001529 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 882097001530 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 882097001531 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 882097001532 catalytic triad [active] 882097001533 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 882097001534 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882097001535 MarR family; Region: MarR_2; pfam12802 882097001536 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097001537 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882097001538 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 882097001539 Ligand Binding Site [chemical binding]; other site 882097001540 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 882097001541 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 882097001542 putative active site [active] 882097001543 putative metal binding site [ion binding]; other site 882097001544 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882097001545 catalytic core [active] 882097001546 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882097001547 Predicted membrane protein [Function unknown]; Region: COG3759 882097001548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097001549 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882097001550 putative substrate translocation pore; other site 882097001551 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 882097001552 non-specific DNA interactions [nucleotide binding]; other site 882097001553 DNA binding site [nucleotide binding] 882097001554 sequence specific DNA binding site [nucleotide binding]; other site 882097001555 putative cAMP binding site [chemical binding]; other site 882097001556 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882097001557 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 882097001558 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 882097001559 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 882097001560 NAD binding site [chemical binding]; other site 882097001561 sugar binding site [chemical binding]; other site 882097001562 divalent metal binding site [ion binding]; other site 882097001563 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882097001564 dimer interface [polypeptide binding]; other site 882097001565 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882097001566 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882097001567 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882097001568 putative active site [active] 882097001569 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 882097001570 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 882097001571 Sulfate transporter family; Region: Sulfate_transp; pfam00916 882097001572 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 882097001573 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 882097001574 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 882097001575 DNA binding residues [nucleotide binding] 882097001576 dimer interface [polypeptide binding]; other site 882097001577 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 882097001578 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 882097001579 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 882097001580 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 882097001581 DXD motif; other site 882097001582 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 882097001583 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 882097001584 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 882097001585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097001586 S-adenosylmethionine binding site [chemical binding]; other site 882097001587 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 882097001588 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 882097001589 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882097001590 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882097001591 DNA binding site [nucleotide binding] 882097001592 domain linker motif; other site 882097001593 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 882097001594 putative dimerization interface [polypeptide binding]; other site 882097001595 putative ligand binding site [chemical binding]; other site 882097001596 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 882097001597 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 882097001598 NAD binding site [chemical binding]; other site 882097001599 sugar binding site [chemical binding]; other site 882097001600 divalent metal binding site [ion binding]; other site 882097001601 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882097001602 dimer interface [polypeptide binding]; other site 882097001603 allantoate amidohydrolase; Reviewed; Region: PRK09290 882097001604 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 882097001605 active site 882097001606 metal binding site [ion binding]; metal-binding site 882097001607 dimer interface [polypeptide binding]; other site 882097001608 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 882097001609 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 882097001610 metal binding site [ion binding]; metal-binding site 882097001611 putative dimer interface [polypeptide binding]; other site 882097001612 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 882097001613 Beta-lactamase; Region: Beta-lactamase; pfam00144 882097001614 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 882097001615 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 882097001616 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 882097001617 intersubunit interface [polypeptide binding]; other site 882097001618 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 882097001619 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 882097001620 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 882097001621 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 882097001622 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 882097001623 Glucitol operon activator protein (GutM); Region: GutM; cl01890 882097001624 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 882097001625 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882097001626 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 882097001627 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 882097001628 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 882097001629 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097001630 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882097001631 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097001632 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097001633 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097001634 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882097001635 WxL domain surface cell wall-binding; Region: WxL; pfam13731 882097001636 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 882097001637 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 882097001638 FOG: CBS domain [General function prediction only]; Region: COG0517 882097001639 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 882097001640 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 882097001641 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 882097001642 dimer interface [polypeptide binding]; other site 882097001643 active site 882097001644 metal binding site [ion binding]; metal-binding site 882097001645 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 882097001646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097001647 putative substrate translocation pore; other site 882097001648 POT family; Region: PTR2; pfam00854 882097001649 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882097001650 catalytic core [active] 882097001651 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882097001652 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882097001653 catalytic core [active] 882097001654 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882097001655 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 882097001656 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 882097001657 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 882097001658 Cl binding site [ion binding]; other site 882097001659 oligomer interface [polypeptide binding]; other site 882097001660 glutamate dehydrogenase; Provisional; Region: PRK09414 882097001661 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 882097001662 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 882097001663 NAD(P) binding site [chemical binding]; other site 882097001664 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 882097001665 metal binding site [ion binding]; metal-binding site 882097001666 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 882097001667 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 882097001668 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 882097001669 substrate binding site [chemical binding]; other site 882097001670 glutamase interaction surface [polypeptide binding]; other site 882097001671 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 882097001672 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 882097001673 catalytic residues [active] 882097001674 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 882097001675 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 882097001676 putative active site [active] 882097001677 oxyanion strand; other site 882097001678 catalytic triad [active] 882097001679 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 882097001680 putative active site pocket [active] 882097001681 4-fold oligomerization interface [polypeptide binding]; other site 882097001682 metal binding residues [ion binding]; metal-binding site 882097001683 3-fold/trimer interface [polypeptide binding]; other site 882097001684 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 882097001685 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 882097001686 NAD binding site [chemical binding]; other site 882097001687 dimerization interface [polypeptide binding]; other site 882097001688 product binding site; other site 882097001689 substrate binding site [chemical binding]; other site 882097001690 zinc binding site [ion binding]; other site 882097001691 catalytic residues [active] 882097001692 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 882097001693 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 882097001694 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 882097001695 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 882097001696 dimer interface [polypeptide binding]; other site 882097001697 motif 1; other site 882097001698 active site 882097001699 motif 2; other site 882097001700 motif 3; other site 882097001701 histidinol-phosphatase; Reviewed; Region: PRK08123 882097001702 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 882097001703 active site 882097001704 dimer interface [polypeptide binding]; other site 882097001705 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 882097001706 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 882097001707 DNA binding site [nucleotide binding] 882097001708 active site 882097001709 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 882097001710 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 882097001711 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882097001712 beta-galactosidase; Region: BGL; TIGR03356 882097001713 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882097001714 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097001715 DNA-binding site [nucleotide binding]; DNA binding site 882097001716 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 882097001717 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001718 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097001719 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 882097001720 Uncharacterized conserved protein [Function unknown]; Region: COG2966 882097001721 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 882097001722 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 882097001723 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 882097001724 Predicted esterase [General function prediction only]; Region: COG0400 882097001725 putative hydrolase; Provisional; Region: PRK11460 882097001726 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 882097001727 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 882097001728 putative RNA binding site [nucleotide binding]; other site 882097001729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097001730 S-adenosylmethionine binding site [chemical binding]; other site 882097001731 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 882097001732 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882097001733 Bacterial SH3 domain; Region: SH3_3; pfam08239 882097001734 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882097001735 NlpC/P60 family; Region: NLPC_P60; pfam00877 882097001736 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 882097001737 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 882097001738 ATP binding site [chemical binding]; other site 882097001739 putative Mg++ binding site [ion binding]; other site 882097001740 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 882097001741 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 882097001742 nucleotide binding region [chemical binding]; other site 882097001743 ATP-binding site [chemical binding]; other site 882097001744 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 882097001745 Domain of unknown function DUF20; Region: UPF0118; pfam01594 882097001746 WxL domain surface cell wall-binding; Region: WxL; pfam13731 882097001747 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 882097001748 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 882097001749 UreD urease accessory protein; Region: UreD; cl00530 882097001750 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 882097001751 DNA photolyase; Region: DNA_photolyase; pfam00875 882097001752 Predicted membrane protein [Function unknown]; Region: COG4852 882097001753 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 882097001754 DAK2 domain; Region: Dak2; pfam02734 882097001755 EDD domain protein, DegV family; Region: DegV; TIGR00762 882097001756 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 882097001757 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 882097001758 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 882097001759 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 882097001760 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 882097001761 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 882097001762 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 882097001763 homodimer interface [polypeptide binding]; other site 882097001764 substrate-cofactor binding pocket; other site 882097001765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097001766 catalytic residue [active] 882097001767 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 882097001768 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 882097001769 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097001770 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 882097001771 ligand binding site [chemical binding]; other site 882097001772 flexible hinge region; other site 882097001773 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882097001774 non-specific DNA interactions [nucleotide binding]; other site 882097001775 DNA binding site [nucleotide binding] 882097001776 sequence specific DNA binding site [nucleotide binding]; other site 882097001777 putative cAMP binding site [chemical binding]; other site 882097001778 BioY family; Region: BioY; pfam02632 882097001779 Predicted transcriptional regulators [Transcription]; Region: COG1695 882097001780 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 882097001781 Predicted membrane protein [Function unknown]; Region: COG4709 882097001782 Uncharacterized conserved protein [Function unknown]; Region: COG3595 882097001783 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 882097001784 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 882097001785 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 882097001786 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 882097001787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097001788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 882097001789 Coenzyme A binding pocket [chemical binding]; other site 882097001790 Tic20-like protein; Region: Tic20; pfam09685 882097001791 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 882097001792 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 882097001793 Transcriptional regulators [Transcription]; Region: MarR; COG1846 882097001794 MarR family; Region: MarR_2; pfam12802 882097001795 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882097001796 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882097001797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097001798 Walker A/P-loop; other site 882097001799 ATP binding site [chemical binding]; other site 882097001800 Q-loop/lid; other site 882097001801 ABC transporter signature motif; other site 882097001802 Walker B; other site 882097001803 D-loop; other site 882097001804 H-loop/switch region; other site 882097001805 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882097001806 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882097001807 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 882097001808 Walker A/P-loop; other site 882097001809 ATP binding site [chemical binding]; other site 882097001810 Q-loop/lid; other site 882097001811 ABC transporter signature motif; other site 882097001812 Walker B; other site 882097001813 D-loop; other site 882097001814 H-loop/switch region; other site 882097001815 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 882097001816 active site residue [active] 882097001817 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 882097001818 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097001819 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 882097001820 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 882097001821 Transcriptional regulators [Transcription]; Region: MarR; COG1846 882097001822 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882097001823 putative DNA binding site [nucleotide binding]; other site 882097001824 putative Zn2+ binding site [ion binding]; other site 882097001825 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 882097001826 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 882097001827 putative NAD(P) binding site [chemical binding]; other site 882097001828 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 882097001829 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 882097001830 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 882097001831 putative active site [active] 882097001832 catalytic site [active] 882097001833 putative metal binding site [ion binding]; other site 882097001834 Catalytic domain of Protein Kinases; Region: PKc; cd00180 882097001835 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 882097001836 active site 882097001837 ATP binding site [chemical binding]; other site 882097001838 substrate binding site [chemical binding]; other site 882097001839 activation loop (A-loop); other site 882097001840 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 882097001841 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 882097001842 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 882097001843 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 882097001844 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097001845 Coenzyme A binding pocket [chemical binding]; other site 882097001846 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 882097001847 active site 882097001848 catalytic triad [active] 882097001849 oxyanion hole [active] 882097001850 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 882097001851 domain interaction interfaces [polypeptide binding]; other site 882097001852 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 882097001853 domain interaction interfaces [polypeptide binding]; other site 882097001854 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 882097001855 domain interaction interfaces [polypeptide binding]; other site 882097001856 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 882097001857 domain interaction interfaces [polypeptide binding]; other site 882097001858 Isochorismatase family; Region: Isochorismatase; pfam00857 882097001859 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 882097001860 catalytic triad [active] 882097001861 conserved cis-peptide bond; other site 882097001862 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 882097001863 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097001864 motif II; other site 882097001865 Predicted transcriptional regulator [Transcription]; Region: COG1959 882097001866 Transcriptional regulator; Region: Rrf2; pfam02082 882097001867 Methyltransferase domain; Region: Methyltransf_31; pfam13847 882097001868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097001869 S-adenosylmethionine binding site [chemical binding]; other site 882097001870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 882097001871 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 882097001872 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882097001873 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882097001874 active site 882097001875 catalytic tetrad [active] 882097001876 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 882097001877 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882097001878 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097001879 motif II; other site 882097001880 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 882097001881 catalytic residue [active] 882097001882 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 882097001883 Sulfatase; Region: Sulfatase; pfam00884 882097001884 amino acid transporter; Region: 2A0306; TIGR00909 882097001885 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 882097001886 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 882097001887 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 882097001888 putative metal binding site [ion binding]; other site 882097001889 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 882097001890 active site 882097001891 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 882097001892 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 882097001893 Cl binding site [ion binding]; other site 882097001894 oligomer interface [polypeptide binding]; other site 882097001895 Transcriptional regulators [Transcription]; Region: GntR; COG1802 882097001896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097001897 DNA-binding site [nucleotide binding]; DNA binding site 882097001898 Predicted membrane protein [Function unknown]; Region: COG1511 882097001899 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 882097001900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097001901 Transcriptional regulators [Transcription]; Region: GntR; COG1802 882097001902 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097001903 DNA-binding site [nucleotide binding]; DNA binding site 882097001904 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 882097001905 Predicted integral membrane protein [Function unknown]; Region: COG5523 882097001906 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 882097001907 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 882097001908 active site 882097001909 metal binding site [ion binding]; metal-binding site 882097001910 Predicted membrane protein [Function unknown]; Region: COG2322 882097001911 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 882097001912 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 882097001913 minor groove reading motif; other site 882097001914 helix-hairpin-helix signature motif; other site 882097001915 substrate binding pocket [chemical binding]; other site 882097001916 active site 882097001917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097001918 non-specific DNA binding site [nucleotide binding]; other site 882097001919 salt bridge; other site 882097001920 sequence-specific DNA binding site [nucleotide binding]; other site 882097001921 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 882097001922 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 882097001923 Transposase; Region: HTH_Tnp_1; cl17663 882097001924 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 882097001925 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 882097001926 dimer interface [polypeptide binding]; other site 882097001927 substrate binding site [chemical binding]; other site 882097001928 ATP binding site [chemical binding]; other site 882097001929 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882097001930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097001931 active site 882097001932 motif I; other site 882097001933 motif II; other site 882097001934 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097001935 maltose O-acetyltransferase; Provisional; Region: PRK10092 882097001936 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 882097001937 active site 882097001938 substrate binding site [chemical binding]; other site 882097001939 trimer interface [polypeptide binding]; other site 882097001940 CoA binding site [chemical binding]; other site 882097001941 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 882097001942 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882097001943 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 882097001944 Walker A/P-loop; other site 882097001945 ATP binding site [chemical binding]; other site 882097001946 Q-loop/lid; other site 882097001947 ABC transporter signature motif; other site 882097001948 Walker B; other site 882097001949 D-loop; other site 882097001950 H-loop/switch region; other site 882097001951 inner membrane transport permease; Provisional; Region: PRK15066 882097001952 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 882097001953 oxidoreductase; Provisional; Region: PRK07985 882097001954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 882097001955 NAD(P) binding site [chemical binding]; other site 882097001956 active site 882097001957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 882097001958 Protein of unknown function (DUF805); Region: DUF805; pfam05656 882097001959 Predicted membrane protein [Function unknown]; Region: COG3152 882097001960 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 882097001961 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 882097001962 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 882097001963 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 882097001964 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 882097001965 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 882097001966 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 882097001967 FHIPEP family; Region: FHIPEP; pfam00771 882097001968 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 882097001969 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 882097001970 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 882097001971 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 882097001972 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 882097001973 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 882097001974 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 882097001975 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 882097001976 flagellar motor protein MotA; Validated; Region: PRK08124 882097001977 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 882097001978 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 882097001979 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 882097001980 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 882097001981 ligand binding site [chemical binding]; other site 882097001982 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 882097001983 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 882097001984 putative metal binding site; other site 882097001985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882097001986 binding surface 882097001987 TPR motif; other site 882097001988 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 882097001989 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 882097001990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097001991 active site 882097001992 phosphorylation site [posttranslational modification] 882097001993 intermolecular recognition site; other site 882097001994 dimerization interface [polypeptide binding]; other site 882097001995 flagellin; Provisional; Region: PRK12805 882097001996 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 882097001997 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 882097001998 Response regulator receiver domain; Region: Response_reg; pfam00072 882097001999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097002000 active site 882097002001 phosphorylation site [posttranslational modification] 882097002002 intermolecular recognition site; other site 882097002003 dimerization interface [polypeptide binding]; other site 882097002004 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 882097002005 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 882097002006 putative binding surface; other site 882097002007 active site 882097002008 P2 response regulator binding domain; Region: P2; pfam07194 882097002009 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 882097002010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097002011 ATP binding site [chemical binding]; other site 882097002012 Mg2+ binding site [ion binding]; other site 882097002013 G-X-G motif; other site 882097002014 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 882097002015 flagellar motor switch protein; Validated; Region: PRK06788 882097002016 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 882097002017 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 882097002018 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 882097002019 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 882097002020 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 882097002021 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 882097002022 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 882097002023 flagellar motor switch protein; Validated; Region: PRK06789 882097002024 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 882097002025 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 882097002026 flagellar motor switch protein; Reviewed; Region: PRK06782 882097002027 CheC-like family; Region: CheC; pfam04509 882097002028 CheC-like family; Region: CheC; pfam04509 882097002029 Chemotaxis phosphatase CheX; Region: CheX; cl15816 882097002030 CheC-like family; Region: CheC; pfam04509 882097002031 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 882097002032 Protein of unknown function (DUF327); Region: DUF327; pfam03885 882097002033 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 882097002034 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 882097002035 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 882097002036 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 882097002037 flagellar capping protein; Validated; Region: fliD; PRK06798 882097002038 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 882097002039 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 882097002040 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 882097002041 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 882097002042 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 882097002043 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 882097002044 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 882097002045 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 882097002046 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 882097002047 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 882097002048 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 882097002049 FliG C-terminal domain; Region: FliG_C; pfam01706 882097002050 flagellar assembly protein H; Validated; Region: fliH; PRK06800 882097002051 Flagellar assembly protein FliH; Region: FliH; pfam02108 882097002052 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 882097002053 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 882097002054 Walker A motif; other site 882097002055 ATP binding site [chemical binding]; other site 882097002056 Walker B motif; other site 882097002057 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 882097002058 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 882097002059 N-acetyl-D-glucosamine binding site [chemical binding]; other site 882097002060 catalytic residue [active] 882097002061 Predicted transcriptional regulators [Transcription]; Region: COG1695 882097002062 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 882097002063 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 882097002064 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 882097002065 pyruvate oxidase; Provisional; Region: PRK08611 882097002066 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 882097002067 PYR/PP interface [polypeptide binding]; other site 882097002068 dimer interface [polypeptide binding]; other site 882097002069 tetramer interface [polypeptide binding]; other site 882097002070 TPP binding site [chemical binding]; other site 882097002071 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 882097002072 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 882097002073 TPP-binding site [chemical binding]; other site 882097002074 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 882097002075 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 882097002076 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882097002077 dimerization interface [polypeptide binding]; other site 882097002078 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 882097002079 dimer interface [polypeptide binding]; other site 882097002080 putative CheW interface [polypeptide binding]; other site 882097002081 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 882097002082 putative active site [active] 882097002083 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 882097002084 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 882097002085 glutaminase active site [active] 882097002086 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 882097002087 dimer interface [polypeptide binding]; other site 882097002088 active site 882097002089 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 882097002090 dimer interface [polypeptide binding]; other site 882097002091 active site 882097002092 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 882097002093 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 882097002094 active site 882097002095 Riboflavin kinase; Region: Flavokinase; cl03312 882097002096 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 882097002097 GIY-YIG motif/motif A; other site 882097002098 Leucine rich repeat; Region: LRR_8; pfam13855 882097002099 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097002100 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097002101 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097002102 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882097002103 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097002104 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097002105 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882097002106 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882097002107 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 882097002108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097002109 non-specific DNA binding site [nucleotide binding]; other site 882097002110 salt bridge; other site 882097002111 sequence-specific DNA binding site [nucleotide binding]; other site 882097002112 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097002113 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 882097002114 ligand binding site [chemical binding]; other site 882097002115 flexible hinge region; other site 882097002116 Predicted transcriptional regulators [Transcription]; Region: COG1725 882097002117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097002118 DNA-binding site [nucleotide binding]; DNA binding site 882097002119 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 882097002120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097002121 Walker A/P-loop; other site 882097002122 ATP binding site [chemical binding]; other site 882097002123 Q-loop/lid; other site 882097002124 ABC transporter signature motif; other site 882097002125 Walker B; other site 882097002126 D-loop; other site 882097002127 H-loop/switch region; other site 882097002128 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882097002129 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 882097002130 Walker A/P-loop; other site 882097002131 ATP binding site [chemical binding]; other site 882097002132 Q-loop/lid; other site 882097002133 ABC transporter signature motif; other site 882097002134 Walker B; other site 882097002135 D-loop; other site 882097002136 H-loop/switch region; other site 882097002137 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882097002138 FtsX-like permease family; Region: FtsX; pfam02687 882097002139 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 882097002140 active site 882097002141 catalytic triad [active] 882097002142 oxyanion hole [active] 882097002143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097002144 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882097002145 Walker A/P-loop; other site 882097002146 ATP binding site [chemical binding]; other site 882097002147 Q-loop/lid; other site 882097002148 ABC transporter signature motif; other site 882097002149 Walker B; other site 882097002150 D-loop; other site 882097002151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 882097002152 H-loop/switch region; other site 882097002153 active site 882097002154 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 882097002155 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 882097002156 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 882097002157 Zn binding site [ion binding]; other site 882097002158 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 882097002159 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882097002160 Zn binding site [ion binding]; other site 882097002161 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 882097002162 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882097002163 Zn binding site [ion binding]; other site 882097002164 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 882097002165 Zn binding site [ion binding]; other site 882097002166 Predicted esterase [General function prediction only]; Region: COG0400 882097002167 putative hydrolase; Provisional; Region: PRK11460 882097002168 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 882097002169 GTPases [General function prediction only]; Region: HflX; COG2262 882097002170 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 882097002171 HflX GTPase family; Region: HflX; cd01878 882097002172 G1 box; other site 882097002173 GTP/Mg2+ binding site [chemical binding]; other site 882097002174 Switch I region; other site 882097002175 G2 box; other site 882097002176 G3 box; other site 882097002177 Switch II region; other site 882097002178 G4 box; other site 882097002179 G5 box; other site 882097002180 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 882097002181 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 882097002182 putative active site [active] 882097002183 putative metal binding site [ion binding]; other site 882097002184 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 882097002185 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 882097002186 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 882097002187 Uncharacterized conserved protein [Function unknown]; Region: COG3538 882097002188 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 882097002189 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 882097002190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097002191 dimer interface [polypeptide binding]; other site 882097002192 conserved gate region; other site 882097002193 putative PBP binding loops; other site 882097002194 ABC-ATPase subunit interface; other site 882097002195 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882097002196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097002197 dimer interface [polypeptide binding]; other site 882097002198 conserved gate region; other site 882097002199 putative PBP binding loops; other site 882097002200 ABC-ATPase subunit interface; other site 882097002201 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 882097002202 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 882097002203 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 882097002204 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097002205 DNA-binding site [nucleotide binding]; DNA binding site 882097002206 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882097002207 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 882097002208 ligand binding site [chemical binding]; other site 882097002209 dimerization interface [polypeptide binding]; other site 882097002210 Transcriptional regulators [Transcription]; Region: GntR; COG1802 882097002211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097002212 DNA-binding site [nucleotide binding]; DNA binding site 882097002213 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 882097002214 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 882097002215 putative NADP binding site [chemical binding]; other site 882097002216 putative dimer interface [polypeptide binding]; other site 882097002217 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 882097002218 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 882097002219 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882097002220 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882097002221 nucleotide binding site [chemical binding]; other site 882097002222 Predicted membrane protein [Function unknown]; Region: COG4811 882097002223 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 882097002224 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 882097002225 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 882097002226 active site 882097002227 phosphorylation site [posttranslational modification] 882097002228 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882097002229 active pocket/dimerization site; other site 882097002230 active site 882097002231 phosphorylation site [posttranslational modification] 882097002232 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 882097002233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097002234 Walker A motif; other site 882097002235 ATP binding site [chemical binding]; other site 882097002236 Walker B motif; other site 882097002237 arginine finger; other site 882097002238 Transcriptional antiterminator [Transcription]; Region: COG3933 882097002239 PRD domain; Region: PRD; pfam00874 882097002240 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882097002241 active pocket/dimerization site; other site 882097002242 active site 882097002243 phosphorylation site [posttranslational modification] 882097002244 PRD domain; Region: PRD; pfam00874 882097002245 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 882097002246 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 882097002247 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 882097002248 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 882097002249 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 882097002250 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 882097002251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 882097002252 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 882097002253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 882097002254 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 882097002255 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 882097002256 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 882097002257 putative deacylase active site [active] 882097002258 Predicted amidohydrolase [General function prediction only]; Region: COG0388 882097002259 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 882097002260 active site 882097002261 catalytic triad [active] 882097002262 dimer interface [polypeptide binding]; other site 882097002263 Protein of unknown function (DUF554); Region: DUF554; pfam04474 882097002264 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 882097002265 NADH(P)-binding; Region: NAD_binding_10; pfam13460 882097002266 NAD binding site [chemical binding]; other site 882097002267 substrate binding site [chemical binding]; other site 882097002268 putative active site [active] 882097002269 Predicted permeases [General function prediction only]; Region: RarD; COG2962 882097002270 EamA-like transporter family; Region: EamA; pfam00892 882097002271 Uncharacterized conserved protein [Function unknown]; Region: COG2353 882097002272 Transcriptional regulators [Transcription]; Region: MarR; COG1846 882097002273 MarR family; Region: MarR_2; pfam12802 882097002274 lysine transporter; Provisional; Region: PRK10836 882097002275 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 882097002276 PAS domain; Region: PAS_9; pfam13426 882097002277 putative active site [active] 882097002278 heme pocket [chemical binding]; other site 882097002279 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882097002280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 882097002281 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 882097002282 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 882097002283 synthetase active site [active] 882097002284 NTP binding site [chemical binding]; other site 882097002285 metal binding site [ion binding]; metal-binding site 882097002286 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 882097002287 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 882097002288 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 882097002289 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097002290 non-specific DNA binding site [nucleotide binding]; other site 882097002291 salt bridge; other site 882097002292 sequence-specific DNA binding site [nucleotide binding]; other site 882097002293 Cupin domain; Region: Cupin_2; pfam07883 882097002294 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 882097002295 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 882097002296 Walker A/P-loop; other site 882097002297 ATP binding site [chemical binding]; other site 882097002298 Q-loop/lid; other site 882097002299 ABC transporter signature motif; other site 882097002300 Walker B; other site 882097002301 D-loop; other site 882097002302 H-loop/switch region; other site 882097002303 TOBE domain; Region: TOBE_2; pfam08402 882097002304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 882097002305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097002306 putative PBP binding loops; other site 882097002307 ABC-ATPase subunit interface; other site 882097002308 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 882097002309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097002310 dimer interface [polypeptide binding]; other site 882097002311 conserved gate region; other site 882097002312 putative PBP binding loops; other site 882097002313 ABC-ATPase subunit interface; other site 882097002314 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 882097002315 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 882097002316 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 882097002317 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 882097002318 active site 882097002319 zinc binding site [ion binding]; other site 882097002320 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 882097002321 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882097002322 Zn2+ binding site [ion binding]; other site 882097002323 Mg2+ binding site [ion binding]; other site 882097002324 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882097002325 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882097002326 nucleotide binding site [chemical binding]; other site 882097002327 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 882097002328 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 882097002329 FMN binding site [chemical binding]; other site 882097002330 substrate binding site [chemical binding]; other site 882097002331 putative catalytic residue [active] 882097002332 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882097002333 MarR family; Region: MarR_2; pfam12802 882097002334 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 882097002335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097002336 Coenzyme A binding pocket [chemical binding]; other site 882097002337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 882097002338 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 882097002339 dimer interface [polypeptide binding]; other site 882097002340 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882097002341 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 882097002342 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 882097002343 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882097002344 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 882097002345 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097002346 motif II; other site 882097002347 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 882097002348 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882097002349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097002350 Coenzyme A binding pocket [chemical binding]; other site 882097002351 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882097002352 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882097002353 DNA binding residues [nucleotide binding] 882097002354 putative dimer interface [polypeptide binding]; other site 882097002355 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882097002356 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882097002357 active site 882097002358 catalytic tetrad [active] 882097002359 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 882097002360 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 882097002361 homodimer interface [polypeptide binding]; other site 882097002362 catalytic residues [active] 882097002363 NAD binding site [chemical binding]; other site 882097002364 substrate binding pocket [chemical binding]; other site 882097002365 flexible flap; other site 882097002366 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 882097002367 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 882097002368 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 882097002369 PhoU domain; Region: PhoU; pfam01895 882097002370 PhoU domain; Region: PhoU; pfam01895 882097002371 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 882097002372 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 882097002373 dimer interface [polypeptide binding]; other site 882097002374 PYR/PP interface [polypeptide binding]; other site 882097002375 TPP binding site [chemical binding]; other site 882097002376 substrate binding site [chemical binding]; other site 882097002377 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 882097002378 Domain of unknown function; Region: EKR; smart00890 882097002379 4Fe-4S binding domain; Region: Fer4_6; pfam12837 882097002380 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 882097002381 TPP-binding site [chemical binding]; other site 882097002382 dimer interface [polypeptide binding]; other site 882097002383 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 882097002384 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 882097002385 Predicted permeases [General function prediction only]; Region: COG0679 882097002386 Transposase; Region: HTH_Tnp_1; cl17663 882097002387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097002388 non-specific DNA binding site [nucleotide binding]; other site 882097002389 salt bridge; other site 882097002390 sequence-specific DNA binding site [nucleotide binding]; other site 882097002391 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 882097002392 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097002393 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097002394 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097002395 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882097002396 Predicted membrane protein [Function unknown]; Region: COG3223 882097002397 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882097002398 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882097002399 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 882097002400 Walker A/P-loop; other site 882097002401 ATP binding site [chemical binding]; other site 882097002402 Q-loop/lid; other site 882097002403 ABC transporter signature motif; other site 882097002404 Walker B; other site 882097002405 D-loop; other site 882097002406 H-loop/switch region; other site 882097002407 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 882097002408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097002409 putative substrate translocation pore; other site 882097002410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097002411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097002412 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882097002413 putative substrate translocation pore; other site 882097002414 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882097002415 MarR family; Region: MarR; pfam01047 882097002416 MarR family; Region: MarR_2; cl17246 882097002417 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 882097002418 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 882097002419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882097002420 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 882097002421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097002422 motif II; other site 882097002423 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 882097002424 Predicted membrane protein [Function unknown]; Region: COG3326 882097002425 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 882097002426 homotrimer interaction site [polypeptide binding]; other site 882097002427 putative active site [active] 882097002428 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 882097002429 substrate binding site [chemical binding]; other site 882097002430 zinc-binding site [ion binding]; other site 882097002431 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 882097002432 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 882097002433 GIY-YIG motif/motif A; other site 882097002434 active site 882097002435 catalytic site [active] 882097002436 putative DNA binding site [nucleotide binding]; other site 882097002437 metal binding site [ion binding]; metal-binding site 882097002438 UvrB/uvrC motif; Region: UVR; pfam02151 882097002439 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 882097002440 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 882097002441 substrate binding pocket [chemical binding]; other site 882097002442 membrane-bound complex binding site; other site 882097002443 hinge residues; other site 882097002444 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 882097002445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097002446 dimer interface [polypeptide binding]; other site 882097002447 conserved gate region; other site 882097002448 putative PBP binding loops; other site 882097002449 ABC-ATPase subunit interface; other site 882097002450 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 882097002451 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 882097002452 Walker A/P-loop; other site 882097002453 ATP binding site [chemical binding]; other site 882097002454 Q-loop/lid; other site 882097002455 ABC transporter signature motif; other site 882097002456 Walker B; other site 882097002457 D-loop; other site 882097002458 H-loop/switch region; other site 882097002459 amidase; Provisional; Region: PRK11910 882097002460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882097002461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882097002462 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 882097002463 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 882097002464 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 882097002465 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 882097002466 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 882097002467 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 882097002468 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 882097002469 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 882097002470 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 882097002471 Esterase/lipase [General function prediction only]; Region: COG1647 882097002472 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882097002473 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882097002474 DNA binding site [nucleotide binding] 882097002475 domain linker motif; other site 882097002476 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 882097002477 putative dimerization interface [polypeptide binding]; other site 882097002478 putative ligand binding site [chemical binding]; other site 882097002479 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 882097002480 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882097002481 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 882097002482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097002483 dimer interface [polypeptide binding]; other site 882097002484 conserved gate region; other site 882097002485 putative PBP binding loops; other site 882097002486 ABC-ATPase subunit interface; other site 882097002487 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882097002488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097002489 dimer interface [polypeptide binding]; other site 882097002490 conserved gate region; other site 882097002491 ABC-ATPase subunit interface; other site 882097002492 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 882097002493 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 882097002494 Ca binding site [ion binding]; other site 882097002495 active site 882097002496 catalytic site [active] 882097002497 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 882097002498 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 882097002499 active site 882097002500 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 882097002501 active site 882097002502 substrate binding site [chemical binding]; other site 882097002503 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 882097002504 metal binding site [ion binding]; metal-binding site 882097002505 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 882097002506 DEAD-like helicases superfamily; Region: DEXDc; smart00487 882097002507 ATP binding site [chemical binding]; other site 882097002508 Mg++ binding site [ion binding]; other site 882097002509 motif III; other site 882097002510 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882097002511 nucleotide binding region [chemical binding]; other site 882097002512 ATP-binding site [chemical binding]; other site 882097002513 Predicted membrane protein [Function unknown]; Region: COG4708 882097002514 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 882097002515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 882097002516 Predicted transcriptional regulators [Transcription]; Region: COG1733 882097002517 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 882097002518 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 882097002519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097002520 putative substrate translocation pore; other site 882097002521 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882097002522 PRD domain; Region: PRD; pfam00874 882097002523 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882097002524 active site 882097002525 P-loop; other site 882097002526 phosphorylation site [posttranslational modification] 882097002527 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097002528 active site 882097002529 phosphorylation site [posttranslational modification] 882097002530 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882097002531 methionine cluster; other site 882097002532 active site 882097002533 phosphorylation site [posttranslational modification] 882097002534 metal binding site [ion binding]; metal-binding site 882097002535 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882097002536 active site 882097002537 P-loop; other site 882097002538 phosphorylation site [posttranslational modification] 882097002539 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882097002540 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882097002541 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 882097002542 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 882097002543 active site 882097002544 trimer interface [polypeptide binding]; other site 882097002545 allosteric site; other site 882097002546 active site lid [active] 882097002547 hexamer (dimer of trimers) interface [polypeptide binding]; other site 882097002548 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882097002549 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882097002550 active site 882097002551 catalytic tetrad [active] 882097002552 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 882097002553 Collagen binding domain; Region: Collagen_bind; pfam05737 882097002554 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 882097002555 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882097002556 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 882097002557 Uncharacterized conserved protein [Function unknown]; Region: COG3402 882097002558 Predicted membrane protein [Function unknown]; Region: COG3428 882097002559 Bacterial PH domain; Region: DUF304; pfam03703 882097002560 Bacterial PH domain; Region: DUF304; pfam03703 882097002561 Bacterial PH domain; Region: DUF304; pfam03703 882097002562 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 882097002563 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 882097002564 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 882097002565 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 882097002566 active site 882097002567 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 882097002568 dimer interface [polypeptide binding]; other site 882097002569 substrate binding site [chemical binding]; other site 882097002570 catalytic residues [active] 882097002571 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 882097002572 PemK-like protein; Region: PemK; pfam02452 882097002573 Rsbr N terminal; Region: Rsbr_N; pfam08678 882097002574 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882097002575 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882097002576 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 882097002577 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 882097002578 ATP binding site [chemical binding]; other site 882097002579 Mg2+ binding site [ion binding]; other site 882097002580 G-X-G motif; other site 882097002581 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 882097002582 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 882097002583 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 882097002584 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 882097002585 anti sigma factor interaction site; other site 882097002586 regulatory phosphorylation site [posttranslational modification]; other site 882097002587 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 882097002588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097002589 ATP binding site [chemical binding]; other site 882097002590 Mg2+ binding site [ion binding]; other site 882097002591 G-X-G motif; other site 882097002592 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 882097002593 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 882097002594 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 882097002595 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 882097002596 DNA binding residues [nucleotide binding] 882097002597 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 882097002598 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 882097002599 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 882097002600 Sulfate transporter family; Region: Sulfate_transp; pfam00916 882097002601 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 882097002602 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 882097002603 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 882097002604 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 882097002605 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 882097002606 RNA binding site [nucleotide binding]; other site 882097002607 hypothetical protein; Provisional; Region: PRK04351 882097002608 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 882097002609 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 882097002610 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 882097002611 Uncharacterized conserved protein [Function unknown]; Region: COG5646 882097002612 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882097002613 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882097002614 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882097002615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097002616 DNA-binding site [nucleotide binding]; DNA binding site 882097002617 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 882097002618 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 882097002619 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 882097002620 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 882097002621 glutathione reductase; Validated; Region: PRK06116 882097002622 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882097002623 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882097002624 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 882097002625 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882097002626 catalytic core [active] 882097002627 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 882097002628 Domain of unknown function DUF20; Region: UPF0118; pfam01594 882097002629 Predicted transcriptional regulators [Transcription]; Region: COG1725 882097002630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097002631 DNA-binding site [nucleotide binding]; DNA binding site 882097002632 Predicted membrane protein [General function prediction only]; Region: COG4194 882097002633 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 882097002634 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 882097002635 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 882097002636 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 882097002637 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 882097002638 tetramerization interface [polypeptide binding]; other site 882097002639 NAD(P) binding site [chemical binding]; other site 882097002640 catalytic residues [active] 882097002641 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 882097002642 active site 882097002643 P-loop; other site 882097002644 phosphorylation site [posttranslational modification] 882097002645 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882097002646 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882097002647 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882097002648 methionine cluster; other site 882097002649 active site 882097002650 phosphorylation site [posttranslational modification] 882097002651 metal binding site [ion binding]; metal-binding site 882097002652 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882097002653 beta-galactosidase; Region: BGL; TIGR03356 882097002654 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882097002655 Mga helix-turn-helix domain; Region: Mga; pfam05043 882097002656 PRD domain; Region: PRD; pfam00874 882097002657 PRD domain; Region: PRD; pfam00874 882097002658 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 882097002659 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097002660 active site 882097002661 phosphorylation site [posttranslational modification] 882097002662 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882097002663 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 882097002664 ABC transporter; Region: ABC_tran_2; pfam12848 882097002665 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882097002666 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 882097002667 Predicted permeases [General function prediction only]; Region: COG0701 882097002668 Predicted membrane protein [Function unknown]; Region: COG3689 882097002669 pantothenate kinase; Provisional; Region: PRK05439 882097002670 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 882097002671 ATP-binding site [chemical binding]; other site 882097002672 CoA-binding site [chemical binding]; other site 882097002673 Mg2+-binding site [ion binding]; other site 882097002674 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 882097002675 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882097002676 Walker A/P-loop; other site 882097002677 ATP binding site [chemical binding]; other site 882097002678 Q-loop/lid; other site 882097002679 ABC transporter signature motif; other site 882097002680 Walker B; other site 882097002681 D-loop; other site 882097002682 H-loop/switch region; other site 882097002683 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 882097002684 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 882097002685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882097002686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882097002687 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 882097002688 Domain of unknown function (DUF373); Region: DUF373; cl12079 882097002689 Sulfatase; Region: Sulfatase; pfam00884 882097002690 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 882097002691 active site 882097002692 DNA binding site [nucleotide binding] 882097002693 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 882097002694 active site 882097002695 catalytic site [active] 882097002696 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 882097002697 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 882097002698 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 882097002699 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 882097002700 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 882097002701 Uncharacterized conserved protein [Function unknown]; Region: COG0398 882097002702 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 882097002703 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 882097002704 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 882097002705 epoxyqueuosine reductase; Region: TIGR00276 882097002706 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 882097002707 A new structural DNA glycosylase; Region: AlkD_like; cl11434 882097002708 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 882097002709 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 882097002710 dimer interface [polypeptide binding]; other site 882097002711 FMN binding site [chemical binding]; other site 882097002712 NADPH bind site [chemical binding]; other site 882097002713 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 882097002714 Low molecular weight phosphatase family; Region: LMWPc; cd00115 882097002715 active site 882097002716 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 882097002717 HSP90 family protein; Provisional; Region: PRK14083 882097002718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097002719 ATP binding site [chemical binding]; other site 882097002720 Mg2+ binding site [ion binding]; other site 882097002721 G-X-G motif; other site 882097002722 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 882097002723 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 882097002724 dimerization interface [polypeptide binding]; other site 882097002725 DPS ferroxidase diiron center [ion binding]; other site 882097002726 ion pore; other site 882097002727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 882097002728 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 882097002729 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882097002730 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 882097002731 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 882097002732 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 882097002733 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 882097002734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097002735 putative substrate translocation pore; other site 882097002736 Transcriptional regulators [Transcription]; Region: FadR; COG2186 882097002737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097002738 DNA-binding site [nucleotide binding]; DNA binding site 882097002739 FCD domain; Region: FCD; pfam07729 882097002740 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 882097002741 Domain of unknown function DUF20; Region: UPF0118; pfam01594 882097002742 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 882097002743 PGAP1-like protein; Region: PGAP1; pfam07819 882097002744 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 882097002745 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 882097002746 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 882097002747 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 882097002748 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 882097002749 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 882097002750 active site 882097002751 dimer interface [polypeptide binding]; other site 882097002752 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 882097002753 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 882097002754 active site 882097002755 trimer interface [polypeptide binding]; other site 882097002756 allosteric site; other site 882097002757 active site lid [active] 882097002758 hexamer (dimer of trimers) interface [polypeptide binding]; other site 882097002759 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882097002760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097002761 DNA-binding site [nucleotide binding]; DNA binding site 882097002762 UTRA domain; Region: UTRA; pfam07702 882097002763 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 882097002764 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 882097002765 Mg++ binding site [ion binding]; other site 882097002766 putative catalytic motif [active] 882097002767 substrate binding site [chemical binding]; other site 882097002768 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 882097002769 Peptidase family U32; Region: Peptidase_U32; pfam01136 882097002770 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 882097002771 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 882097002772 Peptidase family U32; Region: Peptidase_U32; pfam01136 882097002773 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 882097002774 heat shock protein HtpX; Provisional; Region: PRK04897 882097002775 Thioredoxin; Region: Thioredoxin_5; pfam13743 882097002776 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 882097002777 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 882097002778 putative active site [active] 882097002779 putative metal binding residues [ion binding]; other site 882097002780 signature motif; other site 882097002781 putative triphosphate binding site [ion binding]; other site 882097002782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882097002783 TPR motif; other site 882097002784 binding surface 882097002785 Tetratricopeptide repeat; Region: TPR_16; pfam13432 882097002786 Tetratrico peptide repeat; Region: TPR_5; pfam12688 882097002787 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 882097002788 synthetase active site [active] 882097002789 NTP binding site [chemical binding]; other site 882097002790 metal binding site [ion binding]; metal-binding site 882097002791 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 882097002792 ATP-NAD kinase; Region: NAD_kinase; pfam01513 882097002793 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 882097002794 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 882097002795 active site 882097002796 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 882097002797 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 882097002798 NAD binding site [chemical binding]; other site 882097002799 homotetramer interface [polypeptide binding]; other site 882097002800 homodimer interface [polypeptide binding]; other site 882097002801 substrate binding site [chemical binding]; other site 882097002802 active site 882097002803 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 882097002804 DltD N-terminal region; Region: DltD_N; pfam04915 882097002805 DltD central region; Region: DltD_M; pfam04918 882097002806 DltD C-terminal region; Region: DltD_C; pfam04914 882097002807 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 882097002808 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 882097002809 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 882097002810 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 882097002811 acyl-activating enzyme (AAE) consensus motif; other site 882097002812 AMP binding site [chemical binding]; other site 882097002813 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 882097002814 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 882097002815 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882097002816 active site 882097002817 dimer interface [polypeptide binding]; other site 882097002818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097002819 Coenzyme A binding pocket [chemical binding]; other site 882097002820 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 882097002821 Putative esterase; Region: Esterase; pfam00756 882097002822 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 882097002823 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 882097002824 homodimer interface [polypeptide binding]; other site 882097002825 substrate-cofactor binding pocket; other site 882097002826 catalytic residue [active] 882097002827 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 882097002828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097002829 Walker A/P-loop; other site 882097002830 ATP binding site [chemical binding]; other site 882097002831 Q-loop/lid; other site 882097002832 ABC transporter signature motif; other site 882097002833 Walker B; other site 882097002834 D-loop; other site 882097002835 H-loop/switch region; other site 882097002836 ABC-2 type transporter; Region: ABC2_membrane; cl17235 882097002837 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 882097002838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097002839 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882097002840 putative substrate translocation pore; other site 882097002841 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 882097002842 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 882097002843 putative oligomer interface [polypeptide binding]; other site 882097002844 putative active site [active] 882097002845 metal binding site [ion binding]; metal-binding site 882097002846 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 882097002847 catalytic residues [active] 882097002848 dimer interface [polypeptide binding]; other site 882097002849 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 882097002850 LytTr DNA-binding domain; Region: LytTR; smart00850 882097002851 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882097002852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097002853 Walker A/P-loop; other site 882097002854 ATP binding site [chemical binding]; other site 882097002855 Q-loop/lid; other site 882097002856 ABC transporter signature motif; other site 882097002857 Walker B; other site 882097002858 D-loop; other site 882097002859 H-loop/switch region; other site 882097002860 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 882097002861 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 882097002862 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 882097002863 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 882097002864 G1 box; other site 882097002865 putative GEF interaction site [polypeptide binding]; other site 882097002866 GTP/Mg2+ binding site [chemical binding]; other site 882097002867 Switch I region; other site 882097002868 G2 box; other site 882097002869 G3 box; other site 882097002870 Switch II region; other site 882097002871 G4 box; other site 882097002872 G5 box; other site 882097002873 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 882097002874 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882097002875 MarR family; Region: MarR_2; cl17246 882097002876 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 882097002877 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 882097002878 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 882097002879 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 882097002880 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 882097002881 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 882097002882 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 882097002883 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 882097002884 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 882097002885 DNA binding site [nucleotide binding] 882097002886 active site 882097002887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097002888 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 882097002889 Walker A motif; other site 882097002890 ATP binding site [chemical binding]; other site 882097002891 Walker B motif; other site 882097002892 arginine finger; other site 882097002893 UvrB/uvrC motif; Region: UVR; pfam02151 882097002894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097002895 Walker A motif; other site 882097002896 ATP binding site [chemical binding]; other site 882097002897 Walker B motif; other site 882097002898 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 882097002899 CAAX protease self-immunity; Region: Abi; pfam02517 882097002900 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 882097002901 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 882097002902 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 882097002903 nucleotide binding site [chemical binding]; other site 882097002904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 882097002905 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 882097002906 dimerization domain swap beta strand [polypeptide binding]; other site 882097002907 regulatory protein interface [polypeptide binding]; other site 882097002908 active site 882097002909 regulatory phosphorylation site [posttranslational modification]; other site 882097002910 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 882097002911 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 882097002912 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 882097002913 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 882097002914 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 882097002915 Uncharacterized conserved protein [Function unknown]; Region: COG1434 882097002916 putative active site [active] 882097002917 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 882097002918 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 882097002919 aminotransferase A; Validated; Region: PRK07683 882097002920 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882097002921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097002922 homodimer interface [polypeptide binding]; other site 882097002923 catalytic residue [active] 882097002924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 882097002925 FOG: CBS domain [General function prediction only]; Region: COG0517 882097002926 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 882097002927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882097002928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882097002929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 882097002930 dimerization interface [polypeptide binding]; other site 882097002931 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 882097002932 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 882097002933 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 882097002934 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 882097002935 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 882097002936 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 882097002937 metal binding site [ion binding]; metal-binding site 882097002938 putative dimer interface [polypeptide binding]; other site 882097002939 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 882097002940 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 882097002941 Mechanosensitive ion channel; Region: MS_channel; pfam00924 882097002942 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 882097002943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097002944 Walker A/P-loop; other site 882097002945 ATP binding site [chemical binding]; other site 882097002946 Q-loop/lid; other site 882097002947 ABC transporter signature motif; other site 882097002948 Walker B; other site 882097002949 D-loop; other site 882097002950 H-loop/switch region; other site 882097002951 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 882097002952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097002953 dimer interface [polypeptide binding]; other site 882097002954 conserved gate region; other site 882097002955 putative PBP binding loops; other site 882097002956 ABC-ATPase subunit interface; other site 882097002957 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 882097002958 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 882097002959 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 882097002960 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 882097002961 HPr interaction site; other site 882097002962 glycerol kinase (GK) interaction site [polypeptide binding]; other site 882097002963 active site 882097002964 phosphorylation site [posttranslational modification] 882097002965 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 882097002966 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 882097002967 S1 domain; Region: S1_2; pfam13509 882097002968 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 882097002969 RNA binding site [nucleotide binding]; other site 882097002970 Predicted membrane protein [Function unknown]; Region: COG4758 882097002971 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 882097002972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 882097002973 Histidine kinase; Region: HisKA_3; pfam07730 882097002974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097002975 ATP binding site [chemical binding]; other site 882097002976 Mg2+ binding site [ion binding]; other site 882097002977 G-X-G motif; other site 882097002978 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 882097002979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097002980 active site 882097002981 phosphorylation site [posttranslational modification] 882097002982 intermolecular recognition site; other site 882097002983 dimerization interface [polypeptide binding]; other site 882097002984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 882097002985 DNA binding residues [nucleotide binding] 882097002986 dimerization interface [polypeptide binding]; other site 882097002987 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 882097002988 TrkA-N domain; Region: TrkA_N; pfam02254 882097002989 TrkA-C domain; Region: TrkA_C; pfam02080 882097002990 Predicted membrane protein [Function unknown]; Region: COG1289 882097002991 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 882097002992 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 882097002993 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 882097002994 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 882097002995 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 882097002996 hypothetical protein; Provisional; Region: PRK13667 882097002997 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882097002998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097002999 active site 882097003000 motif I; other site 882097003001 motif II; other site 882097003002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097003003 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882097003004 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882097003005 DNA binding site [nucleotide binding] 882097003006 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 882097003007 ligand binding site [chemical binding]; other site 882097003008 dimerization interface [polypeptide binding]; other site 882097003009 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 882097003010 hexamer (dimer of trimers) interface [polypeptide binding]; other site 882097003011 trimer interface [polypeptide binding]; other site 882097003012 substrate binding site [chemical binding]; other site 882097003013 Mn binding site [ion binding]; other site 882097003014 transketolase; Reviewed; Region: PRK05899 882097003015 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 882097003016 TPP-binding site [chemical binding]; other site 882097003017 dimer interface [polypeptide binding]; other site 882097003018 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 882097003019 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 882097003020 PYR/PP interface [polypeptide binding]; other site 882097003021 dimer interface [polypeptide binding]; other site 882097003022 TPP binding site [chemical binding]; other site 882097003023 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882097003024 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 882097003025 Uncharacterized subgroup; belongs to the glycerol kinases subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK_1; cd10427 882097003026 N- and C-terminal domain interface [polypeptide binding]; other site 882097003027 active site 882097003028 MgATP binding site [chemical binding]; other site 882097003029 catalytic site [active] 882097003030 metal binding site [ion binding]; metal-binding site 882097003031 putative glycerol binding site [chemical binding]; other site 882097003032 putative homotetramer interface [polypeptide binding]; other site 882097003033 putative homodimer interface [polypeptide binding]; other site 882097003034 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 882097003035 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882097003036 active site turn [active] 882097003037 phosphorylation site [posttranslational modification] 882097003038 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882097003039 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 882097003040 HPr interaction site; other site 882097003041 glycerol kinase (GK) interaction site [polypeptide binding]; other site 882097003042 active site 882097003043 phosphorylation site [posttranslational modification] 882097003044 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 882097003045 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 882097003046 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 882097003047 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 882097003048 GTP binding site; other site 882097003049 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 882097003050 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 882097003051 Walker A/P-loop; other site 882097003052 ATP binding site [chemical binding]; other site 882097003053 Q-loop/lid; other site 882097003054 ABC transporter signature motif; other site 882097003055 Walker B; other site 882097003056 D-loop; other site 882097003057 H-loop/switch region; other site 882097003058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097003059 dimer interface [polypeptide binding]; other site 882097003060 conserved gate region; other site 882097003061 putative PBP binding loops; other site 882097003062 ABC-ATPase subunit interface; other site 882097003063 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 882097003064 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 882097003065 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 882097003066 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 882097003067 dimer interface [polypeptide binding]; other site 882097003068 putative functional site; other site 882097003069 putative MPT binding site; other site 882097003070 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 882097003071 Walker A motif; other site 882097003072 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 882097003073 MoaE homodimer interface [polypeptide binding]; other site 882097003074 MoaD interaction [polypeptide binding]; other site 882097003075 active site residues [active] 882097003076 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 882097003077 MoaE interaction surface [polypeptide binding]; other site 882097003078 MoeB interaction surface [polypeptide binding]; other site 882097003079 thiocarboxylated glycine; other site 882097003080 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 882097003081 trimer interface [polypeptide binding]; other site 882097003082 dimer interface [polypeptide binding]; other site 882097003083 putative active site [active] 882097003084 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 882097003085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 882097003086 FeS/SAM binding site; other site 882097003087 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 882097003088 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 882097003089 MPT binding site; other site 882097003090 trimer interface [polypeptide binding]; other site 882097003091 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 882097003092 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 882097003093 ATP binding site [chemical binding]; other site 882097003094 substrate interface [chemical binding]; other site 882097003095 Flavin Reductases; Region: FlaRed; cl00801 882097003096 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 882097003097 active site 882097003098 catalytic residues [active] 882097003099 metal binding site [ion binding]; metal-binding site 882097003100 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 882097003101 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 882097003102 TPP-binding site [chemical binding]; other site 882097003103 tetramer interface [polypeptide binding]; other site 882097003104 heterodimer interface [polypeptide binding]; other site 882097003105 phosphorylation loop region [posttranslational modification] 882097003106 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 882097003107 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 882097003108 alpha subunit interface [polypeptide binding]; other site 882097003109 TPP binding site [chemical binding]; other site 882097003110 heterodimer interface [polypeptide binding]; other site 882097003111 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882097003112 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 882097003113 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 882097003114 E3 interaction surface; other site 882097003115 lipoyl attachment site [posttranslational modification]; other site 882097003116 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 882097003117 E3 interaction surface; other site 882097003118 lipoyl attachment site [posttranslational modification]; other site 882097003119 e3 binding domain; Region: E3_binding; pfam02817 882097003120 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 882097003121 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 882097003122 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 882097003123 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882097003124 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 882097003125 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 882097003126 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 882097003127 NAD(P) binding site [chemical binding]; other site 882097003128 LDH/MDH dimer interface [polypeptide binding]; other site 882097003129 substrate binding site [chemical binding]; other site 882097003130 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 882097003131 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 882097003132 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 882097003133 catalytic residues [active] 882097003134 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 882097003135 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 882097003136 Cl binding site [ion binding]; other site 882097003137 oligomer interface [polypeptide binding]; other site 882097003138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 882097003139 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 882097003140 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 882097003141 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 882097003142 active site 882097003143 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 882097003144 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 882097003145 G1 box; other site 882097003146 putative GEF interaction site [polypeptide binding]; other site 882097003147 GTP/Mg2+ binding site [chemical binding]; other site 882097003148 Switch I region; other site 882097003149 G2 box; other site 882097003150 G3 box; other site 882097003151 Switch II region; other site 882097003152 G4 box; other site 882097003153 G5 box; other site 882097003154 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 882097003155 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 882097003156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 882097003157 hypothetical protein; Provisional; Region: PRK13666 882097003158 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 882097003159 pyruvate carboxylase; Reviewed; Region: PRK12999 882097003160 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 882097003161 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 882097003162 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 882097003163 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 882097003164 active site 882097003165 catalytic residues [active] 882097003166 metal binding site [ion binding]; metal-binding site 882097003167 homodimer binding site [polypeptide binding]; other site 882097003168 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 882097003169 carboxyltransferase (CT) interaction site; other site 882097003170 biotinylation site [posttranslational modification]; other site 882097003171 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 882097003172 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 882097003173 putative binding site residues; other site 882097003174 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 882097003175 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 882097003176 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 882097003177 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 882097003178 Walker A/P-loop; other site 882097003179 ATP binding site [chemical binding]; other site 882097003180 Q-loop/lid; other site 882097003181 ABC transporter signature motif; other site 882097003182 Walker B; other site 882097003183 D-loop; other site 882097003184 H-loop/switch region; other site 882097003185 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882097003186 SH3-like domain; Region: SH3_8; pfam13457 882097003187 SH3-like domain; Region: SH3_8; pfam13457 882097003188 SH3-like domain; Region: SH3_8; pfam13457 882097003189 SH3-like domain; Region: SH3_8; pfam13457 882097003190 SH3-like domain; Region: SH3_8; pfam13457 882097003191 SH3-like domain; Region: SH3_8; pfam13457 882097003192 SH3-like domain; Region: SH3_8; pfam13457 882097003193 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 882097003194 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 882097003195 Ligand binding site; other site 882097003196 Putative Catalytic site; other site 882097003197 DXD motif; other site 882097003198 conserved hypothetical integral membrane protein; Region: TIGR03766 882097003199 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 882097003200 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 882097003201 active site 882097003202 tetramer interface; other site 882097003203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 882097003204 active site 882097003205 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 882097003206 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 882097003207 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 882097003208 substrate binding site; other site 882097003209 dimer interface; other site 882097003210 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 882097003211 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 882097003212 putative NAD(P) binding site [chemical binding]; other site 882097003213 putative catalytic Zn binding site [ion binding]; other site 882097003214 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 882097003215 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 882097003216 active site 882097003217 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 882097003218 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 882097003219 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 882097003220 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 882097003221 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 882097003222 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 882097003223 active site 882097003224 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 882097003225 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 882097003226 active site 882097003227 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 882097003228 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 882097003229 homodimer interface [polypeptide binding]; other site 882097003230 NAD binding pocket [chemical binding]; other site 882097003231 ATP binding pocket [chemical binding]; other site 882097003232 Mg binding site [ion binding]; other site 882097003233 active-site loop [active] 882097003234 Uncharacterized conserved protein [Function unknown]; Region: COG1359 882097003235 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 882097003236 active site 882097003237 P-loop; other site 882097003238 phosphorylation site [posttranslational modification] 882097003239 GMP synthase; Reviewed; Region: guaA; PRK00074 882097003240 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 882097003241 AMP/PPi binding site [chemical binding]; other site 882097003242 candidate oxyanion hole; other site 882097003243 catalytic triad [active] 882097003244 potential glutamine specificity residues [chemical binding]; other site 882097003245 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 882097003246 ATP Binding subdomain [chemical binding]; other site 882097003247 Dimerization subdomain; other site 882097003248 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 882097003249 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882097003250 active site 882097003251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882097003252 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882097003253 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 882097003254 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882097003255 active site 882097003256 AAA ATPase domain; Region: AAA_15; pfam13175 882097003257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097003258 Walker A/P-loop; other site 882097003259 ATP binding site [chemical binding]; other site 882097003260 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 882097003261 putative active site [active] 882097003262 putative metal-binding site [ion binding]; other site 882097003263 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 882097003264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097003265 non-specific DNA binding site [nucleotide binding]; other site 882097003266 salt bridge; other site 882097003267 sequence-specific DNA binding site [nucleotide binding]; other site 882097003268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097003269 non-specific DNA binding site [nucleotide binding]; other site 882097003270 salt bridge; other site 882097003271 sequence-specific DNA binding site [nucleotide binding]; other site 882097003272 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 882097003273 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 882097003274 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097003275 Coenzyme A binding pocket [chemical binding]; other site 882097003276 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882097003277 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 882097003278 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882097003279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097003280 Coenzyme A binding pocket [chemical binding]; other site 882097003281 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882097003282 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 882097003283 DNA binding residues [nucleotide binding] 882097003284 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 882097003285 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882097003286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097003287 Walker A/P-loop; other site 882097003288 ATP binding site [chemical binding]; other site 882097003289 Q-loop/lid; other site 882097003290 ABC transporter signature motif; other site 882097003291 Walker B; other site 882097003292 D-loop; other site 882097003293 H-loop/switch region; other site 882097003294 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882097003295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097003296 Walker A/P-loop; other site 882097003297 ATP binding site [chemical binding]; other site 882097003298 Q-loop/lid; other site 882097003299 ABC transporter signature motif; other site 882097003300 Walker B; other site 882097003301 D-loop; other site 882097003302 H-loop/switch region; other site 882097003303 Uncharacterized conserved protein [Function unknown]; Region: COG1359 882097003304 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882097003305 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882097003306 DNA binding residues [nucleotide binding] 882097003307 putative dimer interface [polypeptide binding]; other site 882097003308 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 882097003309 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 882097003310 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882097003311 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882097003312 LRR adjacent; Region: LRR_adjacent; pfam08191 882097003313 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 882097003314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 882097003315 Clp protease; Region: CLP_protease; pfam00574 882097003316 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 882097003317 oligomer interface [polypeptide binding]; other site 882097003318 active site residues [active] 882097003319 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 882097003320 dimer interface [polypeptide binding]; other site 882097003321 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882097003322 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 882097003323 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 882097003324 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 882097003325 SLBB domain; Region: SLBB; pfam10531 882097003326 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 882097003327 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 882097003328 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882097003329 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 882097003330 putative hexamer interface [polypeptide binding]; other site 882097003331 putative hexagonal pore; other site 882097003332 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 882097003333 putative hexamer interface [polypeptide binding]; other site 882097003334 putative hexagonal pore; other site 882097003335 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 882097003336 putative hexamer interface [polypeptide binding]; other site 882097003337 putative hexagonal pore; other site 882097003338 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 882097003339 G1 box; other site 882097003340 GTP/Mg2+ binding site [chemical binding]; other site 882097003341 G2 box; other site 882097003342 Switch I region; other site 882097003343 G3 box; other site 882097003344 Switch II region; other site 882097003345 G4 box; other site 882097003346 G5 box; other site 882097003347 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 882097003348 homotrimer interface [polypeptide binding]; other site 882097003349 Walker A motif; other site 882097003350 GTP binding site [chemical binding]; other site 882097003351 Walker B motif; other site 882097003352 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 882097003353 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882097003354 catalytic core [active] 882097003355 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 882097003356 Sensory domain found in PocR; Region: PocR; pfam10114 882097003357 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882097003358 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882097003359 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882097003360 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882097003361 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 882097003362 Hexamer interface [polypeptide binding]; other site 882097003363 Hexagonal pore residue; other site 882097003364 propanediol utilization protein PduB; Provisional; Region: PRK15415 882097003365 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 882097003366 putative hexamer interface [polypeptide binding]; other site 882097003367 putative hexagonal pore; other site 882097003368 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 882097003369 putative hexamer interface [polypeptide binding]; other site 882097003370 putative hexagonal pore; other site 882097003371 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 882097003372 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 882097003373 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 882097003374 alpha-beta subunit interface [polypeptide binding]; other site 882097003375 alpha-gamma subunit interface [polypeptide binding]; other site 882097003376 active site 882097003377 substrate and K+ binding site; other site 882097003378 K+ binding site [ion binding]; other site 882097003379 cobalamin binding site [chemical binding]; other site 882097003380 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 882097003381 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 882097003382 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 882097003383 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 882097003384 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882097003385 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 882097003386 putative hexamer interface [polypeptide binding]; other site 882097003387 putative hexagonal pore; other site 882097003388 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882097003389 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 882097003390 Hexamer interface [polypeptide binding]; other site 882097003391 Hexagonal pore residue; other site 882097003392 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 882097003393 Propanediol utilisation protein PduL; Region: PduL; pfam06130 882097003394 Propanediol utilisation protein PduL; Region: PduL; pfam06130 882097003395 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 882097003396 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882097003397 nucleotide binding site [chemical binding]; other site 882097003398 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 882097003399 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 882097003400 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 882097003401 Hexamer/Pentamer interface [polypeptide binding]; other site 882097003402 central pore; other site 882097003403 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 882097003404 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 882097003405 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 882097003406 putative catalytic cysteine [active] 882097003407 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 882097003408 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 882097003409 putative active site [active] 882097003410 metal binding site [ion binding]; metal-binding site 882097003411 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 882097003412 amphipathic channel; other site 882097003413 Asn-Pro-Ala signature motifs; other site 882097003414 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 882097003415 propionate/acetate kinase; Provisional; Region: PRK12379 882097003416 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 882097003417 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882097003418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097003419 homodimer interface [polypeptide binding]; other site 882097003420 catalytic residue [active] 882097003421 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 882097003422 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 882097003423 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 882097003424 putative active site [active] 882097003425 metal binding site [ion binding]; metal-binding site 882097003426 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 882097003427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097003428 active site 882097003429 phosphorylation site [posttranslational modification] 882097003430 intermolecular recognition site; other site 882097003431 dimerization interface [polypeptide binding]; other site 882097003432 ANTAR domain; Region: ANTAR; pfam03861 882097003433 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 882097003434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 882097003435 Histidine kinase; Region: HisKA_2; pfam07568 882097003436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097003437 ATP binding site [chemical binding]; other site 882097003438 Mg2+ binding site [ion binding]; other site 882097003439 G-X-G motif; other site 882097003440 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 882097003441 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 882097003442 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 882097003443 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 882097003444 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 882097003445 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 882097003446 putative hexamer interface [polypeptide binding]; other site 882097003447 putative hexagonal pore; other site 882097003448 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 882097003449 putative hexamer interface [polypeptide binding]; other site 882097003450 putative hexagonal pore; other site 882097003451 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882097003452 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 882097003453 Hexamer interface [polypeptide binding]; other site 882097003454 Hexagonal pore residue; other site 882097003455 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 882097003456 putative catalytic cysteine [active] 882097003457 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882097003458 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 882097003459 Hexamer interface [polypeptide binding]; other site 882097003460 Putative hexagonal pore residue; other site 882097003461 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 882097003462 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 882097003463 Propanediol utilisation protein PduL; Region: PduL; pfam06130 882097003464 Propanediol utilisation protein PduL; Region: PduL; pfam06130 882097003465 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 882097003466 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 882097003467 Hexamer/Pentamer interface [polypeptide binding]; other site 882097003468 central pore; other site 882097003469 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 882097003470 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 882097003471 putative hexamer interface [polypeptide binding]; other site 882097003472 putative hexagonal pore; other site 882097003473 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 882097003474 putative hexamer interface [polypeptide binding]; other site 882097003475 putative hexagonal pore; other site 882097003476 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 882097003477 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 882097003478 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 882097003479 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882097003480 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882097003481 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882097003482 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 882097003483 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 882097003484 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 882097003485 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 882097003486 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 882097003487 catalytic triad [active] 882097003488 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 882097003489 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 882097003490 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 882097003491 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 882097003492 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 882097003493 active site 882097003494 putative homodimer interface [polypeptide binding]; other site 882097003495 SAM binding site [chemical binding]; other site 882097003496 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 882097003497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097003498 S-adenosylmethionine binding site [chemical binding]; other site 882097003499 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 882097003500 active site 882097003501 SAM binding site [chemical binding]; other site 882097003502 homodimer interface [polypeptide binding]; other site 882097003503 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 882097003504 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 882097003505 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 882097003506 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 882097003507 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 882097003508 active site 882097003509 SAM binding site [chemical binding]; other site 882097003510 homodimer interface [polypeptide binding]; other site 882097003511 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 882097003512 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 882097003513 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 882097003514 active site 882097003515 SAM binding site [chemical binding]; other site 882097003516 homodimer interface [polypeptide binding]; other site 882097003517 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 882097003518 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 882097003519 active site 882097003520 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 882097003521 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 882097003522 active site 882097003523 C-terminal domain interface [polypeptide binding]; other site 882097003524 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 882097003525 active site 882097003526 N-terminal domain interface [polypeptide binding]; other site 882097003527 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 882097003528 active site 882097003529 SAM binding site [chemical binding]; other site 882097003530 homodimer interface [polypeptide binding]; other site 882097003531 cobalt transport protein CbiM; Validated; Region: PRK08319 882097003532 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 882097003533 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 882097003534 cobalt transport protein CbiQ; Provisional; Region: PRK15485 882097003535 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 882097003536 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 882097003537 Walker A/P-loop; other site 882097003538 ATP binding site [chemical binding]; other site 882097003539 Q-loop/lid; other site 882097003540 ABC transporter signature motif; other site 882097003541 Walker B; other site 882097003542 D-loop; other site 882097003543 H-loop/switch region; other site 882097003544 cobyric acid synthase; Provisional; Region: PRK00784 882097003545 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 882097003546 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 882097003547 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 882097003548 catalytic triad [active] 882097003549 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 882097003550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 882097003551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 882097003552 AAA domain; Region: AAA_17; pfam13207 882097003553 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882097003554 SH3-like domain; Region: SH3_8; pfam13457 882097003555 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882097003556 SH3-like domain; Region: SH3_8; pfam13457 882097003557 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 882097003558 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 882097003559 oligomer interface [polypeptide binding]; other site 882097003560 active site 882097003561 metal binding site [ion binding]; metal-binding site 882097003562 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 882097003563 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 882097003564 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 882097003565 Predicted transcriptional regulators [Transcription]; Region: COG1733 882097003566 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 882097003567 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 882097003568 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 882097003569 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 882097003570 dimer interface [polypeptide binding]; other site 882097003571 motif 1; other site 882097003572 active site 882097003573 motif 2; other site 882097003574 motif 3; other site 882097003575 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 882097003576 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 882097003577 putative tRNA-binding site [nucleotide binding]; other site 882097003578 B3/4 domain; Region: B3_4; pfam03483 882097003579 tRNA synthetase B5 domain; Region: B5; smart00874 882097003580 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 882097003581 dimer interface [polypeptide binding]; other site 882097003582 motif 1; other site 882097003583 motif 3; other site 882097003584 motif 2; other site 882097003585 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 882097003586 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882097003587 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882097003588 Walker A/P-loop; other site 882097003589 ATP binding site [chemical binding]; other site 882097003590 Q-loop/lid; other site 882097003591 ABC transporter signature motif; other site 882097003592 Walker B; other site 882097003593 D-loop; other site 882097003594 H-loop/switch region; other site 882097003595 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882097003596 FtsX-like permease family; Region: FtsX; pfam02687 882097003597 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 882097003598 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882097003599 FtsX-like permease family; Region: FtsX; pfam02687 882097003600 Transcriptional regulators [Transcription]; Region: MarR; COG1846 882097003601 MarR family; Region: MarR; pfam01047 882097003602 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 882097003603 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 882097003604 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 882097003605 ligand binding site [chemical binding]; other site 882097003606 active site 882097003607 UGI interface [polypeptide binding]; other site 882097003608 catalytic site [active] 882097003609 ribonuclease HIII; Provisional; Region: PRK00996 882097003610 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 882097003611 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 882097003612 RNA/DNA hybrid binding site [nucleotide binding]; other site 882097003613 active site 882097003614 Cell division protein ZapA; Region: ZapA; cl01146 882097003615 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 882097003616 Colicin V production protein; Region: Colicin_V; pfam02674 882097003617 hypothetical protein; Provisional; Region: PRK08609 882097003618 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 882097003619 active site 882097003620 primer binding site [nucleotide binding]; other site 882097003621 NTP binding site [chemical binding]; other site 882097003622 metal binding triad [ion binding]; metal-binding site 882097003623 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 882097003624 active site 882097003625 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 882097003626 MutS domain III; Region: MutS_III; pfam05192 882097003627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097003628 Walker A/P-loop; other site 882097003629 ATP binding site [chemical binding]; other site 882097003630 Q-loop/lid; other site 882097003631 ABC transporter signature motif; other site 882097003632 Walker B; other site 882097003633 D-loop; other site 882097003634 H-loop/switch region; other site 882097003635 Smr domain; Region: Smr; pfam01713 882097003636 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882097003637 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 882097003638 catalytic residues [active] 882097003639 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 882097003640 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 882097003641 GIY-YIG motif/motif A; other site 882097003642 active site 882097003643 catalytic site [active] 882097003644 putative DNA binding site [nucleotide binding]; other site 882097003645 metal binding site [ion binding]; metal-binding site 882097003646 UvrB/uvrC motif; Region: UVR; pfam02151 882097003647 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 882097003648 aspartate kinase; Reviewed; Region: PRK06635 882097003649 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 882097003650 putative nucleotide binding site [chemical binding]; other site 882097003651 putative catalytic residues [active] 882097003652 putative Mg ion binding site [ion binding]; other site 882097003653 putative aspartate binding site [chemical binding]; other site 882097003654 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 882097003655 putative allosteric regulatory site; other site 882097003656 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 882097003657 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 882097003658 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 882097003659 ribonuclease PH; Reviewed; Region: rph; PRK00173 882097003660 Ribonuclease PH; Region: RNase_PH_bact; cd11362 882097003661 hexamer interface [polypeptide binding]; other site 882097003662 active site 882097003663 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 882097003664 active site 882097003665 dimerization interface [polypeptide binding]; other site 882097003666 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 882097003667 active site 882097003668 metal binding site [ion binding]; metal-binding site 882097003669 homotetramer interface [polypeptide binding]; other site 882097003670 Uncharacterized conserved protein [Function unknown]; Region: COG5361 882097003671 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 882097003672 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 882097003673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 882097003674 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 882097003675 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 882097003676 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 882097003677 dimer interface [polypeptide binding]; other site 882097003678 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882097003679 catalytic core [active] 882097003680 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 882097003681 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 882097003682 ATP binding site [chemical binding]; other site 882097003683 Mg++ binding site [ion binding]; other site 882097003684 motif III; other site 882097003685 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882097003686 nucleotide binding region [chemical binding]; other site 882097003687 ATP-binding site [chemical binding]; other site 882097003688 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 882097003689 RNA binding site [nucleotide binding]; other site 882097003690 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 882097003691 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 882097003692 putative active site [active] 882097003693 nucleotide binding site [chemical binding]; other site 882097003694 nudix motif; other site 882097003695 putative metal binding site [ion binding]; other site 882097003696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097003697 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882097003698 putative substrate translocation pore; other site 882097003699 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097003700 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882097003701 ligand binding site [chemical binding]; other site 882097003702 flexible hinge region; other site 882097003703 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882097003704 Uncharacterized conserved protein [Function unknown]; Region: COG1284 882097003705 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882097003706 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882097003707 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 882097003708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097003709 DNA-binding site [nucleotide binding]; DNA binding site 882097003710 UTRA domain; Region: UTRA; pfam07702 882097003711 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 882097003712 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 882097003713 Ca binding site [ion binding]; other site 882097003714 active site 882097003715 catalytic site [active] 882097003716 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882097003717 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 882097003718 active site turn [active] 882097003719 phosphorylation site [posttranslational modification] 882097003720 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882097003721 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 882097003722 nudix motif; other site 882097003723 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 882097003724 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 882097003725 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882097003726 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 882097003727 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 882097003728 putative catalytic cysteine [active] 882097003729 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 882097003730 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 882097003731 nucleotide binding site [chemical binding]; other site 882097003732 homotetrameric interface [polypeptide binding]; other site 882097003733 putative phosphate binding site [ion binding]; other site 882097003734 putative allosteric binding site; other site 882097003735 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 882097003736 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 882097003737 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 882097003738 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097003739 non-specific DNA binding site [nucleotide binding]; other site 882097003740 salt bridge; other site 882097003741 sequence-specific DNA binding site [nucleotide binding]; other site 882097003742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097003743 non-specific DNA binding site [nucleotide binding]; other site 882097003744 salt bridge; other site 882097003745 sequence-specific DNA binding site [nucleotide binding]; other site 882097003746 trigger factor; Provisional; Region: tig; PRK01490 882097003747 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 882097003748 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 882097003749 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 882097003750 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 882097003751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097003752 Walker A motif; other site 882097003753 ATP binding site [chemical binding]; other site 882097003754 Walker B motif; other site 882097003755 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 882097003756 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 882097003757 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 882097003758 Catalytic site [active] 882097003759 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 882097003760 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 882097003761 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 882097003762 Catalytic site [active] 882097003763 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 882097003764 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 882097003765 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 882097003766 Catalytic site [active] 882097003767 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 882097003768 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 882097003769 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 882097003770 GTP/Mg2+ binding site [chemical binding]; other site 882097003771 G4 box; other site 882097003772 G5 box; other site 882097003773 G1 box; other site 882097003774 Switch I region; other site 882097003775 G2 box; other site 882097003776 G3 box; other site 882097003777 Switch II region; other site 882097003778 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 882097003779 RNA/DNA hybrid binding site [nucleotide binding]; other site 882097003780 active site 882097003781 DNA protecting protein DprA; Region: dprA; TIGR00732 882097003782 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 882097003783 DNA topoisomerase I; Validated; Region: PRK05582 882097003784 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 882097003785 active site 882097003786 interdomain interaction site; other site 882097003787 putative metal-binding site [ion binding]; other site 882097003788 nucleotide binding site [chemical binding]; other site 882097003789 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 882097003790 domain I; other site 882097003791 DNA binding groove [nucleotide binding] 882097003792 phosphate binding site [ion binding]; other site 882097003793 domain II; other site 882097003794 domain III; other site 882097003795 nucleotide binding site [chemical binding]; other site 882097003796 catalytic site [active] 882097003797 domain IV; other site 882097003798 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 882097003799 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 882097003800 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 882097003801 Glucose inhibited division protein A; Region: GIDA; pfam01134 882097003802 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 882097003803 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 882097003804 active site 882097003805 DNA binding site [nucleotide binding] 882097003806 Int/Topo IB signature motif; other site 882097003807 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 882097003808 active site 882097003809 HslU subunit interaction site [polypeptide binding]; other site 882097003810 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 882097003811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097003812 Walker A motif; other site 882097003813 ATP binding site [chemical binding]; other site 882097003814 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 882097003815 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 882097003816 transcriptional repressor CodY; Validated; Region: PRK04158 882097003817 CodY GAF-like domain; Region: CodY; pfam06018 882097003818 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 882097003819 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 882097003820 active site 882097003821 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 882097003822 active site 882097003823 catalytic residues [active] 882097003824 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 882097003825 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 882097003826 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 882097003827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097003828 Mg2+ binding site [ion binding]; other site 882097003829 G-X-G motif; other site 882097003830 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 882097003831 anchoring element; other site 882097003832 dimer interface [polypeptide binding]; other site 882097003833 ATP binding site [chemical binding]; other site 882097003834 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 882097003835 active site 882097003836 putative metal-binding site [ion binding]; other site 882097003837 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 882097003838 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 882097003839 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 882097003840 CAP-like domain; other site 882097003841 active site 882097003842 primary dimer interface [polypeptide binding]; other site 882097003843 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882097003844 S-ribosylhomocysteinase; Provisional; Region: PRK02260 882097003845 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097003846 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097003847 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097003848 Leucine rich repeat; Region: LRR_8; pfam13855 882097003849 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097003850 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097003851 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882097003852 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882097003853 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 882097003854 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 882097003855 catalytic triad [active] 882097003856 catalytic triad [active] 882097003857 oxyanion hole [active] 882097003858 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 882097003859 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 882097003860 active site 882097003861 catalytic site [active] 882097003862 metal binding site [ion binding]; metal-binding site 882097003863 dimer interface [polypeptide binding]; other site 882097003864 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 882097003865 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 882097003866 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 882097003867 bacterial Hfq-like; Region: Hfq; cd01716 882097003868 hexamer interface [polypeptide binding]; other site 882097003869 Sm1 motif; other site 882097003870 RNA binding site [nucleotide binding]; other site 882097003871 Sm2 motif; other site 882097003872 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 882097003873 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 882097003874 HflX GTPase family; Region: HflX; cd01878 882097003875 G1 box; other site 882097003876 GTP/Mg2+ binding site [chemical binding]; other site 882097003877 Switch I region; other site 882097003878 G2 box; other site 882097003879 G3 box; other site 882097003880 Switch II region; other site 882097003881 G4 box; other site 882097003882 G5 box; other site 882097003883 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 882097003884 Aluminium resistance protein; Region: Alum_res; pfam06838 882097003885 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 882097003886 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 882097003887 DNA binding residues [nucleotide binding] 882097003888 putative dimer interface [polypeptide binding]; other site 882097003889 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 882097003890 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 882097003891 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 882097003892 arsenical pump membrane protein; Provisional; Region: PRK15445 882097003893 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 882097003894 transmembrane helices; other site 882097003895 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 882097003896 LexA repressor; Validated; Region: PRK00215 882097003897 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882097003898 putative DNA binding site [nucleotide binding]; other site 882097003899 putative Zn2+ binding site [ion binding]; other site 882097003900 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 882097003901 Catalytic site [active] 882097003902 cell division suppressor protein YneA; Provisional; Region: PRK14125 882097003903 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 882097003904 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 882097003905 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 882097003906 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 882097003907 TPP-binding site [chemical binding]; other site 882097003908 dimer interface [polypeptide binding]; other site 882097003909 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 882097003910 PYR/PP interface [polypeptide binding]; other site 882097003911 dimer interface [polypeptide binding]; other site 882097003912 TPP binding site [chemical binding]; other site 882097003913 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882097003914 hypothetical protein; Provisional; Region: PRK01844 882097003915 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 882097003916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 882097003917 Methyltransferase domain; Region: Methyltransf_31; pfam13847 882097003918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097003919 S-adenosylmethionine binding site [chemical binding]; other site 882097003920 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 882097003921 ParB-like nuclease domain; Region: ParBc; pfam02195 882097003922 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 882097003923 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 882097003924 Active Sites [active] 882097003925 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 882097003926 DEAD-like helicases superfamily; Region: DEXDc; smart00487 882097003927 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 882097003928 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 882097003929 putative nucleotide binding site [chemical binding]; other site 882097003930 uridine monophosphate binding site [chemical binding]; other site 882097003931 homohexameric interface [polypeptide binding]; other site 882097003932 ribosome recycling factor; Reviewed; Region: frr; PRK00083 882097003933 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 882097003934 hinge region; other site 882097003935 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 882097003936 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 882097003937 catalytic residue [active] 882097003938 putative FPP diphosphate binding site; other site 882097003939 putative FPP binding hydrophobic cleft; other site 882097003940 dimer interface [polypeptide binding]; other site 882097003941 putative IPP diphosphate binding site; other site 882097003942 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 882097003943 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 882097003944 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 882097003945 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 882097003946 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 882097003947 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 882097003948 RIP metalloprotease RseP; Region: TIGR00054 882097003949 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 882097003950 active site 882097003951 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 882097003952 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 882097003953 protein binding site [polypeptide binding]; other site 882097003954 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 882097003955 putative substrate binding region [chemical binding]; other site 882097003956 prolyl-tRNA synthetase; Provisional; Region: PRK09194 882097003957 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 882097003958 dimer interface [polypeptide binding]; other site 882097003959 motif 1; other site 882097003960 active site 882097003961 motif 2; other site 882097003962 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 882097003963 putative deacylase active site [active] 882097003964 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 882097003965 active site 882097003966 motif 3; other site 882097003967 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 882097003968 anticodon binding site; other site 882097003969 DNA polymerase III PolC; Validated; Region: polC; PRK00448 882097003970 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 882097003971 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 882097003972 generic binding surface II; other site 882097003973 generic binding surface I; other site 882097003974 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 882097003975 active site 882097003976 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 882097003977 active site 882097003978 catalytic site [active] 882097003979 substrate binding site [chemical binding]; other site 882097003980 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 882097003981 ribosome maturation protein RimP; Reviewed; Region: PRK00092 882097003982 Sm and related proteins; Region: Sm_like; cl00259 882097003983 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 882097003984 putative oligomer interface [polypeptide binding]; other site 882097003985 putative RNA binding site [nucleotide binding]; other site 882097003986 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 882097003987 NusA N-terminal domain; Region: NusA_N; pfam08529 882097003988 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 882097003989 RNA binding site [nucleotide binding]; other site 882097003990 homodimer interface [polypeptide binding]; other site 882097003991 NusA-like KH domain; Region: KH_5; pfam13184 882097003992 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 882097003993 G-X-X-G motif; other site 882097003994 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 882097003995 putative RNA binding cleft [nucleotide binding]; other site 882097003996 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 882097003997 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 882097003998 translation initiation factor IF-2; Region: IF-2; TIGR00487 882097003999 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 882097004000 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 882097004001 G1 box; other site 882097004002 putative GEF interaction site [polypeptide binding]; other site 882097004003 GTP/Mg2+ binding site [chemical binding]; other site 882097004004 Switch I region; other site 882097004005 G2 box; other site 882097004006 G3 box; other site 882097004007 Switch II region; other site 882097004008 G4 box; other site 882097004009 G5 box; other site 882097004010 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 882097004011 Translation-initiation factor 2; Region: IF-2; pfam11987 882097004012 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 882097004013 Protein of unknown function (DUF503); Region: DUF503; cl00669 882097004014 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 882097004015 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 882097004016 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 882097004017 RNA binding site [nucleotide binding]; other site 882097004018 active site 882097004019 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 882097004020 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 882097004021 active site 882097004022 Riboflavin kinase; Region: Flavokinase; smart00904 882097004023 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 882097004024 16S/18S rRNA binding site [nucleotide binding]; other site 882097004025 S13e-L30e interaction site [polypeptide binding]; other site 882097004026 25S rRNA binding site [nucleotide binding]; other site 882097004027 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 882097004028 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 882097004029 RNase E interface [polypeptide binding]; other site 882097004030 trimer interface [polypeptide binding]; other site 882097004031 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 882097004032 RNase E interface [polypeptide binding]; other site 882097004033 trimer interface [polypeptide binding]; other site 882097004034 active site 882097004035 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 882097004036 putative nucleic acid binding region [nucleotide binding]; other site 882097004037 G-X-X-G motif; other site 882097004038 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 882097004039 RNA binding site [nucleotide binding]; other site 882097004040 domain interface; other site 882097004041 GTPase RsgA; Reviewed; Region: PRK01889 882097004042 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 882097004043 RNA binding site [nucleotide binding]; other site 882097004044 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 882097004045 GTPase/Zn-binding domain interface [polypeptide binding]; other site 882097004046 GTP/Mg2+ binding site [chemical binding]; other site 882097004047 G4 box; other site 882097004048 G5 box; other site 882097004049 G1 box; other site 882097004050 Switch I region; other site 882097004051 G2 box; other site 882097004052 G3 box; other site 882097004053 Switch II region; other site 882097004054 YceG-like family; Region: YceG; pfam02618 882097004055 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 882097004056 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 882097004057 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 882097004058 Rhomboid family; Region: Rhomboid; pfam01694 882097004059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882097004060 TPR motif; other site 882097004061 binding surface 882097004062 TPR repeat; Region: TPR_11; pfam13414 882097004063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 882097004064 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 882097004065 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882097004066 nucleotide binding site [chemical binding]; other site 882097004067 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 882097004068 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 882097004069 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 882097004070 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 882097004071 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 882097004072 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 882097004073 Type II/IV secretion system protein; Region: T2SE; pfam00437 882097004074 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 882097004075 Walker A motif; other site 882097004076 ATP binding site [chemical binding]; other site 882097004077 Walker B motif; other site 882097004078 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 882097004079 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 882097004080 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 882097004081 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 882097004082 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 882097004083 tetramer interface [polypeptide binding]; other site 882097004084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097004085 catalytic residue [active] 882097004086 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 882097004087 tetramer interface [polypeptide binding]; other site 882097004088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097004089 catalytic residue [active] 882097004090 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 882097004091 active site residue [active] 882097004092 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 882097004093 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 882097004094 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 882097004095 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 882097004096 active site 882097004097 elongation factor P; Validated; Region: PRK00529 882097004098 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 882097004099 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 882097004100 RNA binding site [nucleotide binding]; other site 882097004101 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 882097004102 RNA binding site [nucleotide binding]; other site 882097004103 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 882097004104 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 882097004105 carboxyltransferase (CT) interaction site; other site 882097004106 biotinylation site [posttranslational modification]; other site 882097004107 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 882097004108 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 882097004109 ATP-grasp domain; Region: ATP-grasp_4; cl17255 882097004110 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 882097004111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 882097004112 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 882097004113 putative RNA binding site [nucleotide binding]; other site 882097004114 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 882097004115 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 882097004116 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 882097004117 homodimer interface [polypeptide binding]; other site 882097004118 NADP binding site [chemical binding]; other site 882097004119 substrate binding site [chemical binding]; other site 882097004120 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 882097004121 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 882097004122 generic binding surface II; other site 882097004123 generic binding surface I; other site 882097004124 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 882097004125 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 882097004126 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 882097004127 substrate binding pocket [chemical binding]; other site 882097004128 chain length determination region; other site 882097004129 substrate-Mg2+ binding site; other site 882097004130 catalytic residues [active] 882097004131 aspartate-rich region 1; other site 882097004132 active site lid residues [active] 882097004133 aspartate-rich region 2; other site 882097004134 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 882097004135 DNA-binding site [nucleotide binding]; DNA binding site 882097004136 RNA-binding motif; other site 882097004137 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 882097004138 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 882097004139 TPP-binding site; other site 882097004140 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 882097004141 PYR/PP interface [polypeptide binding]; other site 882097004142 dimer interface [polypeptide binding]; other site 882097004143 TPP binding site [chemical binding]; other site 882097004144 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882097004145 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 882097004146 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882097004147 RNA binding surface [nucleotide binding]; other site 882097004148 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 882097004149 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 882097004150 arginine repressor; Provisional; Region: PRK04280 882097004151 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 882097004152 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 882097004153 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 882097004154 Walker A/P-loop; other site 882097004155 ATP binding site [chemical binding]; other site 882097004156 Q-loop/lid; other site 882097004157 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 882097004158 ABC transporter signature motif; other site 882097004159 Walker B; other site 882097004160 D-loop; other site 882097004161 H-loop/switch region; other site 882097004162 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 882097004163 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882097004164 nucleotide binding site [chemical binding]; other site 882097004165 Acetokinase family; Region: Acetate_kinase; cl17229 882097004166 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 882097004167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882097004168 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 882097004169 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 882097004170 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 882097004171 tetramer interface [polypeptide binding]; other site 882097004172 TPP-binding site [chemical binding]; other site 882097004173 heterodimer interface [polypeptide binding]; other site 882097004174 phosphorylation loop region [posttranslational modification] 882097004175 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 882097004176 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 882097004177 alpha subunit interface [polypeptide binding]; other site 882097004178 TPP binding site [chemical binding]; other site 882097004179 heterodimer interface [polypeptide binding]; other site 882097004180 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882097004181 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 882097004182 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 882097004183 E3 interaction surface; other site 882097004184 lipoyl attachment site [posttranslational modification]; other site 882097004185 e3 binding domain; Region: E3_binding; pfam02817 882097004186 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 882097004187 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 882097004188 peptidase T-like protein; Region: PepT-like; TIGR01883 882097004189 metal binding site [ion binding]; metal-binding site 882097004190 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 882097004191 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 882097004192 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 882097004193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882097004194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097004195 active site 882097004196 phosphorylation site [posttranslational modification] 882097004197 intermolecular recognition site; other site 882097004198 dimerization interface [polypeptide binding]; other site 882097004199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882097004200 DNA binding site [nucleotide binding] 882097004201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 882097004202 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882097004203 dimerization interface [polypeptide binding]; other site 882097004204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882097004205 dimer interface [polypeptide binding]; other site 882097004206 phosphorylation site [posttranslational modification] 882097004207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097004208 ATP binding site [chemical binding]; other site 882097004209 Mg2+ binding site [ion binding]; other site 882097004210 G-X-G motif; other site 882097004211 OxaA-like protein precursor; Validated; Region: PRK01622 882097004212 acylphosphatase; Provisional; Region: PRK14443 882097004213 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 882097004214 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 882097004215 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 882097004216 homotetramer interface [polypeptide binding]; other site 882097004217 FMN binding site [chemical binding]; other site 882097004218 homodimer contacts [polypeptide binding]; other site 882097004219 putative active site [active] 882097004220 putative substrate binding site [chemical binding]; other site 882097004221 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 882097004222 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 882097004223 active site residue [active] 882097004224 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 882097004225 Uncharacterized conserved protein [Function unknown]; Region: COG1284 882097004226 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882097004227 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882097004228 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 882097004229 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 882097004230 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 882097004231 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 882097004232 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 882097004233 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 882097004234 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 882097004235 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 882097004236 ligand binding site [chemical binding]; other site 882097004237 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 882097004238 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 882097004239 Walker A/P-loop; other site 882097004240 ATP binding site [chemical binding]; other site 882097004241 Q-loop/lid; other site 882097004242 ABC transporter signature motif; other site 882097004243 Walker B; other site 882097004244 D-loop; other site 882097004245 H-loop/switch region; other site 882097004246 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 882097004247 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 882097004248 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 882097004249 TM-ABC transporter signature motif; other site 882097004250 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 882097004251 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 882097004252 TM-ABC transporter signature motif; other site 882097004253 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 882097004254 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 882097004255 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 882097004256 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 882097004257 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 882097004258 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 882097004259 classical (c) SDRs; Region: SDR_c; cd05233 882097004260 NAD(P) binding site [chemical binding]; other site 882097004261 active site 882097004262 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 882097004263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097004264 non-specific DNA binding site [nucleotide binding]; other site 882097004265 salt bridge; other site 882097004266 sequence-specific DNA binding site [nucleotide binding]; other site 882097004267 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 882097004268 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 882097004269 competence damage-inducible protein A; Provisional; Region: PRK00549 882097004270 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 882097004271 putative MPT binding site; other site 882097004272 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 882097004273 recombinase A; Provisional; Region: recA; PRK09354 882097004274 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 882097004275 hexamer interface [polypeptide binding]; other site 882097004276 Walker A motif; other site 882097004277 ATP binding site [chemical binding]; other site 882097004278 Walker B motif; other site 882097004279 phosphodiesterase; Provisional; Region: PRK12704 882097004280 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882097004281 Zn2+ binding site [ion binding]; other site 882097004282 Mg2+ binding site [ion binding]; other site 882097004283 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 882097004284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097004285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 882097004286 Coenzyme A binding pocket [chemical binding]; other site 882097004287 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 882097004288 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 882097004289 putative active site [active] 882097004290 metal binding site [ion binding]; metal-binding site 882097004291 homodimer binding site [polypeptide binding]; other site 882097004292 Predicted membrane protein [Function unknown]; Region: COG4550 882097004293 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 882097004294 MutS domain I; Region: MutS_I; pfam01624 882097004295 MutS domain II; Region: MutS_II; pfam05188 882097004296 MutS domain III; Region: MutS_III; pfam05192 882097004297 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 882097004298 Walker A/P-loop; other site 882097004299 ATP binding site [chemical binding]; other site 882097004300 Q-loop/lid; other site 882097004301 ABC transporter signature motif; other site 882097004302 Walker B; other site 882097004303 D-loop; other site 882097004304 H-loop/switch region; other site 882097004305 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 882097004306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097004307 ATP binding site [chemical binding]; other site 882097004308 Mg2+ binding site [ion binding]; other site 882097004309 G-X-G motif; other site 882097004310 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 882097004311 ATP binding site [chemical binding]; other site 882097004312 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 882097004313 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 882097004314 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 882097004315 Pyruvate formate lyase 1; Region: PFL1; cd01678 882097004316 coenzyme A binding site [chemical binding]; other site 882097004317 active site 882097004318 catalytic residues [active] 882097004319 glycine loop; other site 882097004320 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 882097004321 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 882097004322 FeS/SAM binding site; other site 882097004323 Predicted transcriptional regulators [Transcription]; Region: COG1695 882097004324 Transcriptional regulator PadR-like family; Region: PadR; cl17335 882097004325 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 882097004326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097004327 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882097004328 putative substrate translocation pore; other site 882097004329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097004330 non-specific DNA binding site [nucleotide binding]; other site 882097004331 salt bridge; other site 882097004332 sequence-specific DNA binding site [nucleotide binding]; other site 882097004333 AAA domain; Region: AAA_17; pfam13207 882097004334 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097004335 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097004336 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097004337 putative acyltransferase; Provisional; Region: PRK05790 882097004338 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 882097004339 dimer interface [polypeptide binding]; other site 882097004340 active site 882097004341 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 882097004342 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 882097004343 dimer interface [polypeptide binding]; other site 882097004344 active site 882097004345 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 882097004346 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 882097004347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097004348 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 882097004349 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 882097004350 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 882097004351 Domain of unknown function DUF20; Region: UPF0118; pfam01594 882097004352 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 882097004353 FAD binding domain; Region: FAD_binding_4; pfam01565 882097004354 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 882097004355 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 882097004356 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 882097004357 Walker A/P-loop; other site 882097004358 ATP binding site [chemical binding]; other site 882097004359 Q-loop/lid; other site 882097004360 ABC transporter signature motif; other site 882097004361 Walker B; other site 882097004362 D-loop; other site 882097004363 H-loop/switch region; other site 882097004364 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 882097004365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097004366 dimer interface [polypeptide binding]; other site 882097004367 conserved gate region; other site 882097004368 ABC-ATPase subunit interface; other site 882097004369 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 882097004370 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 882097004371 manganese transport protein MntH; Reviewed; Region: PRK00701 882097004372 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 882097004373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097004374 dimer interface [polypeptide binding]; other site 882097004375 conserved gate region; other site 882097004376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 882097004377 ABC-ATPase subunit interface; other site 882097004378 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 882097004379 LysR substrate binding domain; Region: LysR_substrate; pfam03466 882097004380 dimerization interface [polypeptide binding]; other site 882097004381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097004382 dimer interface [polypeptide binding]; other site 882097004383 conserved gate region; other site 882097004384 putative PBP binding loops; other site 882097004385 ABC-ATPase subunit interface; other site 882097004386 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 882097004387 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 882097004388 Walker A/P-loop; other site 882097004389 ATP binding site [chemical binding]; other site 882097004390 Q-loop/lid; other site 882097004391 ABC transporter signature motif; other site 882097004392 Walker B; other site 882097004393 D-loop; other site 882097004394 H-loop/switch region; other site 882097004395 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 882097004396 Predicted membrane protein [Function unknown]; Region: COG3859 882097004397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 882097004398 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 882097004399 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882097004400 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882097004401 ABC transporter; Region: ABC_tran_2; pfam12848 882097004402 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882097004403 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 882097004404 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 882097004405 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882097004406 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882097004407 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 882097004408 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 882097004409 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882097004410 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 882097004411 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 882097004412 dihydrodipicolinate synthase; Region: dapA; TIGR00674 882097004413 dimer interface [polypeptide binding]; other site 882097004414 active site 882097004415 catalytic residue [active] 882097004416 aspartate kinase I; Reviewed; Region: PRK08210 882097004417 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 882097004418 nucleotide binding site [chemical binding]; other site 882097004419 substrate binding site [chemical binding]; other site 882097004420 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 882097004421 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 882097004422 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 882097004423 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 882097004424 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 882097004425 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 882097004426 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 882097004427 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 882097004428 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 882097004429 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 882097004430 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 882097004431 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 882097004432 Predicted membrane protein [Function unknown]; Region: COG4392 882097004433 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 882097004434 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 882097004435 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 882097004436 metal binding site 2 [ion binding]; metal-binding site 882097004437 putative DNA binding helix; other site 882097004438 metal binding site 1 [ion binding]; metal-binding site 882097004439 dimer interface [polypeptide binding]; other site 882097004440 structural Zn2+ binding site [ion binding]; other site 882097004441 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 882097004442 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882097004443 ABC-ATPase subunit interface; other site 882097004444 dimer interface [polypeptide binding]; other site 882097004445 putative PBP binding regions; other site 882097004446 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 882097004447 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 882097004448 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 882097004449 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 882097004450 DHHA2 domain; Region: DHHA2; pfam02833 882097004451 endonuclease IV; Provisional; Region: PRK01060 882097004452 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 882097004453 AP (apurinic/apyrimidinic) site pocket; other site 882097004454 DNA interaction; other site 882097004455 Metal-binding active site; metal-binding site 882097004456 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 882097004457 DEAD-like helicases superfamily; Region: DEXDc; smart00487 882097004458 ATP binding site [chemical binding]; other site 882097004459 Mg++ binding site [ion binding]; other site 882097004460 motif III; other site 882097004461 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882097004462 nucleotide binding region [chemical binding]; other site 882097004463 ATP-binding site [chemical binding]; other site 882097004464 Uncharacterized conserved protein [Function unknown]; Region: COG0327 882097004465 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 882097004466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 882097004467 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 882097004468 Uncharacterized conserved protein [Function unknown]; Region: COG0327 882097004469 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 882097004470 Family of unknown function (DUF633); Region: DUF633; pfam04816 882097004471 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 882097004472 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 882097004473 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 882097004474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 882097004475 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 882097004476 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 882097004477 DNA binding residues [nucleotide binding] 882097004478 DNA primase; Validated; Region: dnaG; PRK05667 882097004479 CHC2 zinc finger; Region: zf-CHC2; pfam01807 882097004480 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 882097004481 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 882097004482 active site 882097004483 metal binding site [ion binding]; metal-binding site 882097004484 interdomain interaction site; other site 882097004485 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 882097004486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 882097004487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 882097004488 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 882097004489 DALR anticodon binding domain; Region: DALR_1; pfam05746 882097004490 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 882097004491 dimer interface [polypeptide binding]; other site 882097004492 motif 1; other site 882097004493 active site 882097004494 motif 2; other site 882097004495 motif 3; other site 882097004496 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 882097004497 Recombination protein O N terminal; Region: RecO_N; pfam11967 882097004498 Recombination protein O C terminal; Region: RecO_C; pfam02565 882097004499 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 882097004500 GTPase Era; Reviewed; Region: era; PRK00089 882097004501 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 882097004502 G1 box; other site 882097004503 GTP/Mg2+ binding site [chemical binding]; other site 882097004504 Switch I region; other site 882097004505 G2 box; other site 882097004506 Switch II region; other site 882097004507 G3 box; other site 882097004508 G4 box; other site 882097004509 G5 box; other site 882097004510 KH domain; Region: KH_2; pfam07650 882097004511 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 882097004512 active site 882097004513 catalytic motif [active] 882097004514 Zn binding site [ion binding]; other site 882097004515 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 882097004516 metal-binding heat shock protein; Provisional; Region: PRK00016 882097004517 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 882097004518 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 882097004519 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882097004520 Zn2+ binding site [ion binding]; other site 882097004521 Mg2+ binding site [ion binding]; other site 882097004522 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 882097004523 PhoH-like protein; Region: PhoH; pfam02562 882097004524 Yqey-like protein; Region: YqeY; pfam09424 882097004525 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 882097004526 RNA methyltransferase, RsmE family; Region: TIGR00046 882097004527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 882097004528 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 882097004529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097004530 S-adenosylmethionine binding site [chemical binding]; other site 882097004531 chaperone protein DnaJ; Provisional; Region: PRK14280 882097004532 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 882097004533 HSP70 interaction site [polypeptide binding]; other site 882097004534 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 882097004535 substrate binding site [polypeptide binding]; other site 882097004536 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 882097004537 Zn binding sites [ion binding]; other site 882097004538 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 882097004539 dimer interface [polypeptide binding]; other site 882097004540 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 882097004541 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 882097004542 nucleotide binding site [chemical binding]; other site 882097004543 NEF interaction site [polypeptide binding]; other site 882097004544 SBD interface [polypeptide binding]; other site 882097004545 heat shock protein GrpE; Provisional; Region: PRK14140 882097004546 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 882097004547 dimer interface [polypeptide binding]; other site 882097004548 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 882097004549 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 882097004550 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 882097004551 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 882097004552 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 882097004553 FeS/SAM binding site; other site 882097004554 HemN C-terminal domain; Region: HemN_C; pfam06969 882097004555 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 882097004556 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 882097004557 NADP binding site [chemical binding]; other site 882097004558 putative substrate binding site [chemical binding]; other site 882097004559 active site 882097004560 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882097004561 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882097004562 DNA binding residues [nucleotide binding] 882097004563 putative dimer interface [polypeptide binding]; other site 882097004564 GTP-binding protein LepA; Provisional; Region: PRK05433 882097004565 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 882097004566 G1 box; other site 882097004567 putative GEF interaction site [polypeptide binding]; other site 882097004568 GTP/Mg2+ binding site [chemical binding]; other site 882097004569 Switch I region; other site 882097004570 G2 box; other site 882097004571 G3 box; other site 882097004572 Switch II region; other site 882097004573 G4 box; other site 882097004574 G5 box; other site 882097004575 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 882097004576 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 882097004577 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 882097004578 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 882097004579 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 882097004580 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 882097004581 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 882097004582 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 882097004583 Competence protein; Region: Competence; pfam03772 882097004584 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882097004585 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 882097004586 catalytic motif [active] 882097004587 Zn binding site [ion binding]; other site 882097004588 SLBB domain; Region: SLBB; pfam10531 882097004589 comEA protein; Region: comE; TIGR01259 882097004590 Helix-hairpin-helix motif; Region: HHH; pfam00633 882097004591 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 882097004592 DNA binding site [nucleotide binding] 882097004593 Methyltransferase domain; Region: Methyltransf_23; pfam13489 882097004594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097004595 S-adenosylmethionine binding site [chemical binding]; other site 882097004596 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 882097004597 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882097004598 Zn2+ binding site [ion binding]; other site 882097004599 Mg2+ binding site [ion binding]; other site 882097004600 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 882097004601 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 882097004602 active site 882097004603 (T/H)XGH motif; other site 882097004604 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 882097004605 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 882097004606 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 882097004607 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 882097004608 shikimate binding site; other site 882097004609 NAD(P) binding site [chemical binding]; other site 882097004610 GTPase YqeH; Provisional; Region: PRK13796 882097004611 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 882097004612 GTP/Mg2+ binding site [chemical binding]; other site 882097004613 G4 box; other site 882097004614 G5 box; other site 882097004615 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 882097004616 G1 box; other site 882097004617 G1 box; other site 882097004618 GTP/Mg2+ binding site [chemical binding]; other site 882097004619 G2 box; other site 882097004620 Switch I region; other site 882097004621 G2 box; other site 882097004622 Switch I region; other site 882097004623 G3 box; other site 882097004624 G3 box; other site 882097004625 Switch II region; other site 882097004626 Switch II region; other site 882097004627 G4 box; other site 882097004628 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 882097004629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097004630 motif II; other site 882097004631 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 882097004632 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 882097004633 active site 882097004634 Zn binding site [ion binding]; other site 882097004635 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 882097004636 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 882097004637 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 882097004638 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 882097004639 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 882097004640 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 882097004641 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 882097004642 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 882097004643 Sugar specificity; other site 882097004644 Pyrimidine base specificity; other site 882097004645 ATP-binding site [chemical binding]; other site 882097004646 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 882097004647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097004648 S-adenosylmethionine binding site [chemical binding]; other site 882097004649 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 882097004650 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 882097004651 dimerization interface [polypeptide binding]; other site 882097004652 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 882097004653 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 882097004654 hypothetical protein; Provisional; Region: PRK13678 882097004655 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 882097004656 hypothetical protein; Provisional; Region: PRK05473 882097004657 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 882097004658 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 882097004659 motif 1; other site 882097004660 active site 882097004661 motif 2; other site 882097004662 motif 3; other site 882097004663 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 882097004664 DHHA1 domain; Region: DHHA1; pfam02272 882097004665 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882097004666 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882097004667 Walker A/P-loop; other site 882097004668 ATP binding site [chemical binding]; other site 882097004669 Q-loop/lid; other site 882097004670 ABC transporter signature motif; other site 882097004671 Walker B; other site 882097004672 D-loop; other site 882097004673 H-loop/switch region; other site 882097004674 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882097004675 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882097004676 FtsX-like permease family; Region: FtsX; pfam02687 882097004677 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882097004678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097004679 active site 882097004680 phosphorylation site [posttranslational modification] 882097004681 intermolecular recognition site; other site 882097004682 dimerization interface [polypeptide binding]; other site 882097004683 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882097004684 DNA binding site [nucleotide binding] 882097004685 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 882097004686 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882097004687 dimerization interface [polypeptide binding]; other site 882097004688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882097004689 dimer interface [polypeptide binding]; other site 882097004690 phosphorylation site [posttranslational modification] 882097004691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097004692 ATP binding site [chemical binding]; other site 882097004693 Mg2+ binding site [ion binding]; other site 882097004694 G-X-G motif; other site 882097004695 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 882097004696 AAA domain; Region: AAA_30; pfam13604 882097004697 Family description; Region: UvrD_C_2; pfam13538 882097004698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882097004699 binding surface 882097004700 TPR motif; other site 882097004701 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 882097004702 TPR repeat; Region: TPR_11; pfam13414 882097004703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882097004704 binding surface 882097004705 TPR motif; other site 882097004706 TPR repeat; Region: TPR_11; pfam13414 882097004707 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 882097004708 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 882097004709 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 882097004710 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 882097004711 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 882097004712 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882097004713 catalytic residue [active] 882097004714 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 882097004715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097004716 Walker A motif; other site 882097004717 ATP binding site [chemical binding]; other site 882097004718 Walker B motif; other site 882097004719 arginine finger; other site 882097004720 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 882097004721 Predicted transcriptional regulator [Transcription]; Region: COG1959 882097004722 Transcriptional regulator; Region: Rrf2; pfam02082 882097004723 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 882097004724 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 882097004725 Nitrogen regulatory protein P-II; Region: P-II; smart00938 882097004726 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 882097004727 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 882097004728 dimer interface [polypeptide binding]; other site 882097004729 anticodon binding site; other site 882097004730 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 882097004731 homodimer interface [polypeptide binding]; other site 882097004732 motif 1; other site 882097004733 active site 882097004734 motif 2; other site 882097004735 GAD domain; Region: GAD; pfam02938 882097004736 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 882097004737 active site 882097004738 motif 3; other site 882097004739 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 882097004740 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 882097004741 dimer interface [polypeptide binding]; other site 882097004742 motif 1; other site 882097004743 active site 882097004744 motif 2; other site 882097004745 motif 3; other site 882097004746 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 882097004747 anticodon binding site; other site 882097004748 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 882097004749 Bacterial SH3 domain; Region: SH3_3; pfam08239 882097004750 Bacterial SH3 domain; Region: SH3_3; pfam08239 882097004751 Bacterial SH3 domain homologues; Region: SH3b; smart00287 882097004752 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 882097004753 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 882097004754 active site 882097004755 metal binding site [ion binding]; metal-binding site 882097004756 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 882097004757 putative active site [active] 882097004758 dimerization interface [polypeptide binding]; other site 882097004759 putative tRNAtyr binding site [nucleotide binding]; other site 882097004760 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 882097004761 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882097004762 Zn2+ binding site [ion binding]; other site 882097004763 Mg2+ binding site [ion binding]; other site 882097004764 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 882097004765 synthetase active site [active] 882097004766 NTP binding site [chemical binding]; other site 882097004767 metal binding site [ion binding]; metal-binding site 882097004768 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 882097004769 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 882097004770 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882097004771 active site 882097004772 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 882097004773 DHH family; Region: DHH; pfam01368 882097004774 DHHA1 domain; Region: DHHA1; pfam02272 882097004775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 882097004776 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 882097004777 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 882097004778 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 882097004779 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 882097004780 Protein export membrane protein; Region: SecD_SecF; pfam02355 882097004781 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 882097004782 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 882097004783 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 882097004784 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 882097004785 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 882097004786 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 882097004787 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 882097004788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097004789 Walker A motif; other site 882097004790 ATP binding site [chemical binding]; other site 882097004791 Walker B motif; other site 882097004792 arginine finger; other site 882097004793 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 882097004794 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 882097004795 RuvA N terminal domain; Region: RuvA_N; pfam01330 882097004796 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 882097004797 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 882097004798 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882097004799 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 882097004800 NAD binding site [chemical binding]; other site 882097004801 dimer interface [polypeptide binding]; other site 882097004802 substrate binding site [chemical binding]; other site 882097004803 hypothetical protein; Validated; Region: PRK00110 882097004804 prephenate dehydratase; Provisional; Region: PRK11898 882097004805 Prephenate dehydratase; Region: PDT; pfam00800 882097004806 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 882097004807 putative L-Phe binding site [chemical binding]; other site 882097004808 GTPase CgtA; Reviewed; Region: obgE; PRK12297 882097004809 GTP1/OBG; Region: GTP1_OBG; pfam01018 882097004810 Obg GTPase; Region: Obg; cd01898 882097004811 G1 box; other site 882097004812 GTP/Mg2+ binding site [chemical binding]; other site 882097004813 Switch I region; other site 882097004814 G2 box; other site 882097004815 G3 box; other site 882097004816 Switch II region; other site 882097004817 G4 box; other site 882097004818 G5 box; other site 882097004819 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 882097004820 glycerol kinase; Provisional; Region: glpK; PRK00047 882097004821 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 882097004822 N- and C-terminal domain interface [polypeptide binding]; other site 882097004823 active site 882097004824 MgATP binding site [chemical binding]; other site 882097004825 catalytic site [active] 882097004826 metal binding site [ion binding]; metal-binding site 882097004827 glycerol binding site [chemical binding]; other site 882097004828 homotetramer interface [polypeptide binding]; other site 882097004829 homodimer interface [polypeptide binding]; other site 882097004830 FBP binding site [chemical binding]; other site 882097004831 protein IIAGlc interface [polypeptide binding]; other site 882097004832 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 882097004833 amphipathic channel; other site 882097004834 Asn-Pro-Ala signature motifs; other site 882097004835 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 882097004836 hypothetical protein; Provisional; Region: PRK14553 882097004837 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 882097004838 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 882097004839 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 882097004840 homodimer interface [polypeptide binding]; other site 882097004841 oligonucleotide binding site [chemical binding]; other site 882097004842 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 882097004843 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 882097004844 Switch I; other site 882097004845 Switch II; other site 882097004846 septum formation inhibitor; Reviewed; Region: minC; PRK00513 882097004847 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 882097004848 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 882097004849 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 882097004850 Protein of unknown function (DUF972); Region: DUF972; pfam06156 882097004851 rod shape-determining protein MreC; Region: MreC; pfam04085 882097004852 rod shape-determining protein MreB; Provisional; Region: PRK13927 882097004853 MreB and similar proteins; Region: MreB_like; cd10225 882097004854 nucleotide binding site [chemical binding]; other site 882097004855 Mg binding site [ion binding]; other site 882097004856 putative protofilament interaction site [polypeptide binding]; other site 882097004857 RodZ interaction site [polypeptide binding]; other site 882097004858 hypothetical protein; Reviewed; Region: PRK00024 882097004859 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 882097004860 MPN+ (JAMM) motif; other site 882097004861 Zinc-binding site [ion binding]; other site 882097004862 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 882097004863 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 882097004864 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 882097004865 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 882097004866 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 882097004867 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 882097004868 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 882097004869 active site 882097004870 HIGH motif; other site 882097004871 nucleotide binding site [chemical binding]; other site 882097004872 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 882097004873 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 882097004874 active site 882097004875 KMSKS motif; other site 882097004876 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 882097004877 tRNA binding surface [nucleotide binding]; other site 882097004878 anticodon binding site; other site 882097004879 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 882097004880 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 882097004881 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 882097004882 inhibitor-cofactor binding pocket; inhibition site 882097004883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097004884 catalytic residue [active] 882097004885 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 882097004886 dimer interface [polypeptide binding]; other site 882097004887 active site 882097004888 Schiff base residues; other site 882097004889 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 882097004890 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 882097004891 active site 882097004892 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 882097004893 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 882097004894 domain interfaces; other site 882097004895 active site 882097004896 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 882097004897 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 882097004898 tRNA; other site 882097004899 putative tRNA binding site [nucleotide binding]; other site 882097004900 putative NADP binding site [chemical binding]; other site 882097004901 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 882097004902 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 882097004903 G1 box; other site 882097004904 GTP/Mg2+ binding site [chemical binding]; other site 882097004905 Switch I region; other site 882097004906 G2 box; other site 882097004907 G3 box; other site 882097004908 Switch II region; other site 882097004909 G4 box; other site 882097004910 G5 box; other site 882097004911 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 882097004912 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 882097004913 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 882097004914 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 882097004915 active site 882097004916 dimer interface [polypeptide binding]; other site 882097004917 motif 1; other site 882097004918 motif 2; other site 882097004919 motif 3; other site 882097004920 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 882097004921 anticodon binding site; other site 882097004922 primosomal protein DnaI; Reviewed; Region: PRK08939 882097004923 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 882097004924 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 882097004925 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 882097004926 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 882097004927 ATP cone domain; Region: ATP-cone; pfam03477 882097004928 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 882097004929 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 882097004930 CoA-binding site [chemical binding]; other site 882097004931 ATP-binding [chemical binding]; other site 882097004932 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 882097004933 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 882097004934 DNA binding site [nucleotide binding] 882097004935 catalytic residue [active] 882097004936 H2TH interface [polypeptide binding]; other site 882097004937 putative catalytic residues [active] 882097004938 turnover-facilitating residue; other site 882097004939 intercalation triad [nucleotide binding]; other site 882097004940 8OG recognition residue [nucleotide binding]; other site 882097004941 putative reading head residues; other site 882097004942 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 882097004943 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 882097004944 DNA polymerase I; Provisional; Region: PRK05755 882097004945 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 882097004946 active site 882097004947 metal binding site 1 [ion binding]; metal-binding site 882097004948 putative 5' ssDNA interaction site; other site 882097004949 metal binding site 3; metal-binding site 882097004950 metal binding site 2 [ion binding]; metal-binding site 882097004951 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 882097004952 putative DNA binding site [nucleotide binding]; other site 882097004953 putative metal binding site [ion binding]; other site 882097004954 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 882097004955 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 882097004956 active site 882097004957 DNA binding site [nucleotide binding] 882097004958 catalytic site [active] 882097004959 isocitrate dehydrogenase; Reviewed; Region: PRK07006 882097004960 isocitrate dehydrogenase; Validated; Region: PRK07362 882097004961 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 882097004962 dimer interface [polypeptide binding]; other site 882097004963 Citrate synthase; Region: Citrate_synt; pfam00285 882097004964 active site 882097004965 citrylCoA binding site [chemical binding]; other site 882097004966 oxalacetate/citrate binding site [chemical binding]; other site 882097004967 coenzyme A binding site [chemical binding]; other site 882097004968 catalytic triad [active] 882097004969 Protein of unknown function (DUF441); Region: DUF441; pfam04284 882097004970 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 882097004971 pyruvate kinase; Provisional; Region: PRK06354 882097004972 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 882097004973 domain interfaces; other site 882097004974 active site 882097004975 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 882097004976 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 882097004977 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 882097004978 active site 882097004979 ADP/pyrophosphate binding site [chemical binding]; other site 882097004980 dimerization interface [polypeptide binding]; other site 882097004981 allosteric effector site; other site 882097004982 fructose-1,6-bisphosphate binding site; other site 882097004983 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 882097004984 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 882097004985 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 882097004986 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 882097004987 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 882097004988 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 882097004989 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 882097004990 active site 882097004991 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 882097004992 generic binding surface I; other site 882097004993 generic binding surface II; other site 882097004994 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 882097004995 DHH family; Region: DHH; pfam01368 882097004996 DHHA1 domain; Region: DHHA1; pfam02272 882097004997 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 882097004998 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 882097004999 active site 2 [active] 882097005000 active site 1 [active] 882097005001 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 882097005002 DNA-binding site [nucleotide binding]; DNA binding site 882097005003 DRTGG domain; Region: DRTGG; pfam07085 882097005004 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 882097005005 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 882097005006 metal-dependent hydrolase; Provisional; Region: PRK00685 882097005007 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 882097005008 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 882097005009 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 882097005010 active site 882097005011 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 882097005012 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 882097005013 hexamer interface [polypeptide binding]; other site 882097005014 ligand binding site [chemical binding]; other site 882097005015 putative active site [active] 882097005016 NAD(P) binding site [chemical binding]; other site 882097005017 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 882097005018 Ligand Binding Site [chemical binding]; other site 882097005019 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 882097005020 propionate/acetate kinase; Provisional; Region: PRK12379 882097005021 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 882097005022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097005023 S-adenosylmethionine binding site [chemical binding]; other site 882097005024 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 882097005025 dimer interface [polypeptide binding]; other site 882097005026 catalytic triad [active] 882097005027 peroxidatic and resolving cysteines [active] 882097005028 RDD family; Region: RDD; pfam06271 882097005029 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 882097005030 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 882097005031 tandem repeat interface [polypeptide binding]; other site 882097005032 oligomer interface [polypeptide binding]; other site 882097005033 active site residues [active] 882097005034 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 882097005035 ATP-NAD kinase; Region: NAD_kinase; pfam01513 882097005036 ornithine carbamoyltransferase; Provisional; Region: PRK00779 882097005037 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 882097005038 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 882097005039 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 882097005040 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 882097005041 inhibitor-cofactor binding pocket; inhibition site 882097005042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097005043 catalytic residue [active] 882097005044 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 882097005045 nucleotide binding site [chemical binding]; other site 882097005046 N-acetyl-L-glutamate binding site [chemical binding]; other site 882097005047 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 882097005048 heterotetramer interface [polypeptide binding]; other site 882097005049 active site pocket [active] 882097005050 cleavage site 882097005051 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 882097005052 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 882097005053 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 882097005054 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 882097005055 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 882097005056 Ligand Binding Site [chemical binding]; other site 882097005057 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 882097005058 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 882097005059 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882097005060 catalytic residue [active] 882097005061 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 882097005062 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 882097005063 GAF domain; Region: GAF_2; pfam13185 882097005064 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 882097005065 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 882097005066 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882097005067 RNA binding surface [nucleotide binding]; other site 882097005068 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 882097005069 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 882097005070 active site 882097005071 HIGH motif; other site 882097005072 dimer interface [polypeptide binding]; other site 882097005073 KMSKS motif; other site 882097005074 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882097005075 RNA binding surface [nucleotide binding]; other site 882097005076 catabolite control protein A; Region: ccpA; TIGR01481 882097005077 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882097005078 DNA binding site [nucleotide binding] 882097005079 domain linker motif; other site 882097005080 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 882097005081 dimerization interface [polypeptide binding]; other site 882097005082 effector binding site; other site 882097005083 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 882097005084 Chorismate mutase type II; Region: CM_2; cl00693 882097005085 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 882097005086 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 882097005087 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 882097005088 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 882097005089 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 882097005090 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 882097005091 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 882097005092 dimer interface [polypeptide binding]; other site 882097005093 decamer (pentamer of dimers) interface [polypeptide binding]; other site 882097005094 catalytic triad [active] 882097005095 peroxidatic and resolving cysteines [active] 882097005096 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 882097005097 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 882097005098 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 882097005099 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 882097005100 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 882097005101 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 882097005102 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 882097005103 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 882097005104 putative tRNA-binding site [nucleotide binding]; other site 882097005105 hypothetical protein; Provisional; Region: PRK13668 882097005106 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882097005107 catalytic residues [active] 882097005108 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 882097005109 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 882097005110 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 882097005111 oligomer interface [polypeptide binding]; other site 882097005112 active site 882097005113 metal binding site [ion binding]; metal-binding site 882097005114 Predicted small secreted protein [Function unknown]; Region: COG5584 882097005115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 882097005116 putative homodimer interface [polypeptide binding]; other site 882097005117 putative homotetramer interface [polypeptide binding]; other site 882097005118 putative allosteric switch controlling residues; other site 882097005119 putative metal binding site [ion binding]; other site 882097005120 putative homodimer-homodimer interface [polypeptide binding]; other site 882097005121 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882097005122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097005123 S-adenosylmethionine binding site [chemical binding]; other site 882097005124 Phosphotransferase enzyme family; Region: APH; pfam01636 882097005125 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 882097005126 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 882097005127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097005128 putative substrate translocation pore; other site 882097005129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097005130 MarR family; Region: MarR; pfam01047 882097005131 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 882097005132 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 882097005133 homodimer interface [polypeptide binding]; other site 882097005134 substrate-cofactor binding pocket; other site 882097005135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097005136 catalytic residue [active] 882097005137 dipeptidase PepV; Reviewed; Region: PRK07318 882097005138 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 882097005139 active site 882097005140 metal binding site [ion binding]; metal-binding site 882097005141 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 882097005142 nudix motif; other site 882097005143 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 882097005144 putative substrate binding site [chemical binding]; other site 882097005145 putative ATP binding site [chemical binding]; other site 882097005146 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 882097005147 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 882097005148 active site 882097005149 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 882097005150 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 882097005151 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 882097005152 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 882097005153 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 882097005154 substrate binding site [chemical binding]; other site 882097005155 active site 882097005156 catalytic residues [active] 882097005157 heterodimer interface [polypeptide binding]; other site 882097005158 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 882097005159 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 882097005160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097005161 catalytic residue [active] 882097005162 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 882097005163 active site 882097005164 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 882097005165 active site 882097005166 ribulose/triose binding site [chemical binding]; other site 882097005167 phosphate binding site [ion binding]; other site 882097005168 substrate (anthranilate) binding pocket [chemical binding]; other site 882097005169 product (indole) binding pocket [chemical binding]; other site 882097005170 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 882097005171 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 882097005172 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 882097005173 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 882097005174 Glutamine amidotransferase class-I; Region: GATase; pfam00117 882097005175 glutamine binding [chemical binding]; other site 882097005176 catalytic triad [active] 882097005177 anthranilate synthase component I; Provisional; Region: PRK13570 882097005178 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 882097005179 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 882097005180 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 882097005181 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 882097005182 putative catalytic cysteine [active] 882097005183 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 882097005184 putative active site [active] 882097005185 metal binding site [ion binding]; metal-binding site 882097005186 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 882097005187 dimer interface [polypeptide binding]; other site 882097005188 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882097005189 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 882097005190 Walker A/P-loop; other site 882097005191 ATP binding site [chemical binding]; other site 882097005192 Q-loop/lid; other site 882097005193 ABC transporter signature motif; other site 882097005194 Walker B; other site 882097005195 D-loop; other site 882097005196 H-loop/switch region; other site 882097005197 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 882097005198 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 882097005199 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 882097005200 putative dimer interface [polypeptide binding]; other site 882097005201 catalytic triad [active] 882097005202 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 882097005203 aconitate hydratase; Validated; Region: PRK09277 882097005204 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 882097005205 substrate binding site [chemical binding]; other site 882097005206 ligand binding site [chemical binding]; other site 882097005207 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 882097005208 substrate binding site [chemical binding]; other site 882097005209 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882097005210 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 882097005211 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 882097005212 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882097005213 ATP binding site [chemical binding]; other site 882097005214 putative Mg++ binding site [ion binding]; other site 882097005215 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882097005216 nucleotide binding region [chemical binding]; other site 882097005217 ATP-binding site [chemical binding]; other site 882097005218 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 882097005219 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 882097005220 Walker A/P-loop; other site 882097005221 ATP binding site [chemical binding]; other site 882097005222 Q-loop/lid; other site 882097005223 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 882097005224 ABC transporter signature motif; other site 882097005225 Walker B; other site 882097005226 D-loop; other site 882097005227 H-loop/switch region; other site 882097005228 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 882097005229 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 882097005230 active site 882097005231 metal binding site [ion binding]; metal-binding site 882097005232 DNA binding site [nucleotide binding] 882097005233 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 882097005234 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 882097005235 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 882097005236 putative acyl-acceptor binding pocket; other site 882097005237 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 882097005238 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882097005239 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882097005240 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 882097005241 Walker A/P-loop; other site 882097005242 ATP binding site [chemical binding]; other site 882097005243 Q-loop/lid; other site 882097005244 ABC transporter signature motif; other site 882097005245 Walker B; other site 882097005246 D-loop; other site 882097005247 H-loop/switch region; other site 882097005248 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882097005249 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 882097005250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097005251 Walker A/P-loop; other site 882097005252 ATP binding site [chemical binding]; other site 882097005253 Q-loop/lid; other site 882097005254 ABC transporter signature motif; other site 882097005255 Walker B; other site 882097005256 D-loop; other site 882097005257 H-loop/switch region; other site 882097005258 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 882097005259 active site 882097005260 elongation factor Ts; Provisional; Region: tsf; PRK09377 882097005261 UBA/TS-N domain; Region: UBA; pfam00627 882097005262 Elongation factor TS; Region: EF_TS; pfam00889 882097005263 Elongation factor TS; Region: EF_TS; pfam00889 882097005264 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 882097005265 rRNA interaction site [nucleotide binding]; other site 882097005266 S8 interaction site; other site 882097005267 putative laminin-1 binding site; other site 882097005268 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 882097005269 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882097005270 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 882097005271 active site turn [active] 882097005272 phosphorylation site [posttranslational modification] 882097005273 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882097005274 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 882097005275 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 882097005276 putative active site [active] 882097005277 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882097005278 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882097005279 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882097005280 putative active site [active] 882097005281 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 882097005282 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 882097005283 HIGH motif; other site 882097005284 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 882097005285 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 882097005286 active site 882097005287 KMSKS motif; other site 882097005288 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 882097005289 tRNA binding surface [nucleotide binding]; other site 882097005290 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 882097005291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 882097005292 FeS/SAM binding site; other site 882097005293 Methyltransferase domain; Region: Methyltransf_31; pfam13847 882097005294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097005295 S-adenosylmethionine binding site [chemical binding]; other site 882097005296 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 882097005297 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 882097005298 active site 882097005299 dimer interface [polypeptide binding]; other site 882097005300 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 882097005301 Ligand Binding Site [chemical binding]; other site 882097005302 Molecular Tunnel; other site 882097005303 S-adenosylmethionine synthetase; Validated; Region: PRK05250 882097005304 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 882097005305 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 882097005306 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 882097005307 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 882097005308 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882097005309 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 882097005310 NAD binding site [chemical binding]; other site 882097005311 dimer interface [polypeptide binding]; other site 882097005312 substrate binding site [chemical binding]; other site 882097005313 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 882097005314 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 882097005315 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 882097005316 nudix motif; other site 882097005317 Uncharacterized conserved protein [Function unknown]; Region: COG0759 882097005318 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 882097005319 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 882097005320 metal binding site [ion binding]; metal-binding site 882097005321 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 882097005322 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 882097005323 acyl-activating enzyme (AAE) consensus motif; other site 882097005324 putative AMP binding site [chemical binding]; other site 882097005325 putative active site [active] 882097005326 putative CoA binding site [chemical binding]; other site 882097005327 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 882097005328 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 882097005329 substrate binding site [chemical binding]; other site 882097005330 oxyanion hole (OAH) forming residues; other site 882097005331 trimer interface [polypeptide binding]; other site 882097005332 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 882097005333 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 882097005334 TAP-like protein; Region: Abhydrolase_4; pfam08386 882097005335 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 882097005336 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 882097005337 dimer interface [polypeptide binding]; other site 882097005338 tetramer interface [polypeptide binding]; other site 882097005339 PYR/PP interface [polypeptide binding]; other site 882097005340 TPP binding site [chemical binding]; other site 882097005341 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 882097005342 TPP-binding site; other site 882097005343 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 882097005344 chorismate binding enzyme; Region: Chorismate_bind; cl10555 882097005345 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 882097005346 UbiA prenyltransferase family; Region: UbiA; pfam01040 882097005347 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 882097005348 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 882097005349 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 882097005350 FAD binding site [chemical binding]; other site 882097005351 cystathionine beta-lyase; Provisional; Region: PRK08064 882097005352 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 882097005353 homodimer interface [polypeptide binding]; other site 882097005354 substrate-cofactor binding pocket; other site 882097005355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097005356 catalytic residue [active] 882097005357 cystathionine gamma-synthase; Reviewed; Region: PRK08247 882097005358 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 882097005359 homodimer interface [polypeptide binding]; other site 882097005360 substrate-cofactor binding pocket; other site 882097005361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097005362 catalytic residue [active] 882097005363 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 882097005364 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 882097005365 THF binding site; other site 882097005366 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 882097005367 substrate binding site [chemical binding]; other site 882097005368 THF binding site; other site 882097005369 zinc-binding site [ion binding]; other site 882097005370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097005371 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882097005372 putative substrate translocation pore; other site 882097005373 ferric uptake regulator; Provisional; Region: fur; PRK09462 882097005374 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 882097005375 metal binding site 2 [ion binding]; metal-binding site 882097005376 putative DNA binding helix; other site 882097005377 metal binding site 1 [ion binding]; metal-binding site 882097005378 dimer interface [polypeptide binding]; other site 882097005379 structural Zn2+ binding site [ion binding]; other site 882097005380 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 882097005381 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 882097005382 NAD binding site [chemical binding]; other site 882097005383 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 882097005384 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 882097005385 inhibitor-cofactor binding pocket; inhibition site 882097005386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097005387 catalytic residue [active] 882097005388 Predicted membrane protein [Function unknown]; Region: COG4129 882097005389 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 882097005390 hypothetical protein; Provisional; Region: PRK13662 882097005391 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 882097005392 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 882097005393 putative NAD(P) binding site [chemical binding]; other site 882097005394 active site 882097005395 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 882097005396 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 882097005397 minor groove reading motif; other site 882097005398 helix-hairpin-helix signature motif; other site 882097005399 substrate binding pocket [chemical binding]; other site 882097005400 active site 882097005401 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 882097005402 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 882097005403 DNA binding and oxoG recognition site [nucleotide binding] 882097005404 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 882097005405 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 882097005406 trimer interface [polypeptide binding]; other site 882097005407 active site 882097005408 WVELL protein; Region: WVELL; pfam14043 882097005409 recombination regulator RecX; Provisional; Region: recX; PRK14135 882097005410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 882097005411 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 882097005412 NAD(P) binding site [chemical binding]; other site 882097005413 active site 882097005414 Predicted integral membrane protein [Function unknown]; Region: COG0392 882097005415 Uncharacterized conserved protein [Function unknown]; Region: COG2898 882097005416 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 882097005417 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 882097005418 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 882097005419 Cation efflux family; Region: Cation_efflux; pfam01545 882097005420 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 882097005421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 882097005422 PAS fold; Region: PAS_4; pfam08448 882097005423 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 882097005424 putative active site [active] 882097005425 heme pocket [chemical binding]; other site 882097005426 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 882097005427 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 882097005428 dimer interface [polypeptide binding]; other site 882097005429 putative CheW interface [polypeptide binding]; other site 882097005430 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 882097005431 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 882097005432 dimer interface [polypeptide binding]; other site 882097005433 active site 882097005434 Mn binding site [ion binding]; other site 882097005435 TRAM domain; Region: TRAM; cl01282 882097005436 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 882097005437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097005438 S-adenosylmethionine binding site [chemical binding]; other site 882097005439 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 882097005440 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 882097005441 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 882097005442 Substrate-binding site [chemical binding]; other site 882097005443 Substrate specificity [chemical binding]; other site 882097005444 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 882097005445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 882097005446 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 882097005447 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 882097005448 active site 882097005449 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 882097005450 flavodoxin, short chain; Region: flav_short; TIGR01753 882097005451 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 882097005452 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 882097005453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097005454 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882097005455 putative substrate translocation pore; other site 882097005456 rod-share determining protein MreBH; Provisional; Region: PRK13929 882097005457 MreB and similar proteins; Region: MreB_like; cd10225 882097005458 nucleotide binding site [chemical binding]; other site 882097005459 Mg binding site [ion binding]; other site 882097005460 putative protofilament interaction site [polypeptide binding]; other site 882097005461 RodZ interaction site [polypeptide binding]; other site 882097005462 Methyltransferase domain; Region: Methyltransf_31; pfam13847 882097005463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097005464 S-adenosylmethionine binding site [chemical binding]; other site 882097005465 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882097005466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882097005467 Uncharacterized conserved protein [Function unknown]; Region: COG3589 882097005468 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 882097005469 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882097005470 methionine cluster; other site 882097005471 active site 882097005472 phosphorylation site [posttranslational modification] 882097005473 metal binding site [ion binding]; metal-binding site 882097005474 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882097005475 active site 882097005476 P-loop; other site 882097005477 phosphorylation site [posttranslational modification] 882097005478 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 882097005479 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 882097005480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097005481 Walker A motif; other site 882097005482 ATP binding site [chemical binding]; other site 882097005483 Walker B motif; other site 882097005484 arginine finger; other site 882097005485 Transcriptional antiterminator [Transcription]; Region: COG3933 882097005486 PRD domain; Region: PRD; pfam00874 882097005487 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882097005488 active pocket/dimerization site; other site 882097005489 active site 882097005490 phosphorylation site [posttranslational modification] 882097005491 PRD domain; Region: PRD; pfam00874 882097005492 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 882097005493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 882097005494 ATP binding site [chemical binding]; other site 882097005495 putative Mg++ binding site [ion binding]; other site 882097005496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882097005497 nucleotide binding region [chemical binding]; other site 882097005498 ATP-binding site [chemical binding]; other site 882097005499 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 882097005500 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882097005501 Walker A/P-loop; other site 882097005502 ATP binding site [chemical binding]; other site 882097005503 Q-loop/lid; other site 882097005504 ABC transporter signature motif; other site 882097005505 Walker B; other site 882097005506 D-loop; other site 882097005507 H-loop/switch region; other site 882097005508 Predicted transcriptional regulators [Transcription]; Region: COG1725 882097005509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097005510 DNA-binding site [nucleotide binding]; DNA binding site 882097005511 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882097005512 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882097005513 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882097005514 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882097005515 DNA binding site [nucleotide binding] 882097005516 domain linker motif; other site 882097005517 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 882097005518 dimerization interface [polypeptide binding]; other site 882097005519 ligand binding site [chemical binding]; other site 882097005520 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 882097005521 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 882097005522 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 882097005523 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 882097005524 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 882097005525 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882097005526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097005527 dimer interface [polypeptide binding]; other site 882097005528 conserved gate region; other site 882097005529 putative PBP binding loops; other site 882097005530 ABC-ATPase subunit interface; other site 882097005531 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882097005532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097005533 dimer interface [polypeptide binding]; other site 882097005534 conserved gate region; other site 882097005535 putative PBP binding loops; other site 882097005536 ABC-ATPase subunit interface; other site 882097005537 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 882097005538 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 882097005539 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 882097005540 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 882097005541 active site 882097005542 dimer interface [polypeptide binding]; other site 882097005543 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 882097005544 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 882097005545 active site 882097005546 FMN binding site [chemical binding]; other site 882097005547 substrate binding site [chemical binding]; other site 882097005548 3Fe-4S cluster binding site [ion binding]; other site 882097005549 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 882097005550 domain interface; other site 882097005551 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882097005552 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882097005553 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 882097005554 putative dimerization interface [polypeptide binding]; other site 882097005555 Predicted acetyltransferase [General function prediction only]; Region: COG3153 882097005556 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 882097005557 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 882097005558 putative active site [active] 882097005559 metal binding site [ion binding]; metal-binding site 882097005560 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 882097005561 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 882097005562 substrate binding pocket [chemical binding]; other site 882097005563 membrane-bound complex binding site; other site 882097005564 hinge residues; other site 882097005565 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882097005566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097005567 Walker A/P-loop; other site 882097005568 ATP binding site [chemical binding]; other site 882097005569 Q-loop/lid; other site 882097005570 ABC transporter signature motif; other site 882097005571 Walker B; other site 882097005572 D-loop; other site 882097005573 H-loop/switch region; other site 882097005574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097005575 dimer interface [polypeptide binding]; other site 882097005576 conserved gate region; other site 882097005577 putative PBP binding loops; other site 882097005578 ABC-ATPase subunit interface; other site 882097005579 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 882097005580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 882097005581 dimer interface [polypeptide binding]; other site 882097005582 phosphorylation site [posttranslational modification] 882097005583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097005584 ATP binding site [chemical binding]; other site 882097005585 Mg2+ binding site [ion binding]; other site 882097005586 G-X-G motif; other site 882097005587 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 882097005588 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 882097005589 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 882097005590 active site 882097005591 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 882097005592 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 882097005593 putative NAD(P) binding site [chemical binding]; other site 882097005594 active site 882097005595 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882097005596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097005597 active site 882097005598 phosphorylation site [posttranslational modification] 882097005599 intermolecular recognition site; other site 882097005600 dimerization interface [polypeptide binding]; other site 882097005601 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882097005602 DNA binding site [nucleotide binding] 882097005603 FtsX-like permease family; Region: FtsX; pfam02687 882097005604 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882097005605 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882097005606 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882097005607 Walker A/P-loop; other site 882097005608 ATP binding site [chemical binding]; other site 882097005609 Q-loop/lid; other site 882097005610 ABC transporter signature motif; other site 882097005611 Walker B; other site 882097005612 D-loop; other site 882097005613 H-loop/switch region; other site 882097005614 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 882097005615 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 882097005616 ADP binding site [chemical binding]; other site 882097005617 magnesium binding site [ion binding]; other site 882097005618 putative shikimate binding site; other site 882097005619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 882097005620 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 882097005621 TRAM domain; Region: TRAM; pfam01938 882097005622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097005623 S-adenosylmethionine binding site [chemical binding]; other site 882097005624 putative lipid kinase; Reviewed; Region: PRK13337 882097005625 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 882097005626 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 882097005627 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 882097005628 GatB domain; Region: GatB_Yqey; smart00845 882097005629 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 882097005630 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 882097005631 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 882097005632 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 882097005633 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 882097005634 putative dimer interface [polypeptide binding]; other site 882097005635 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 882097005636 putative dimer interface [polypeptide binding]; other site 882097005637 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 882097005638 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 882097005639 nucleotide binding pocket [chemical binding]; other site 882097005640 K-X-D-G motif; other site 882097005641 catalytic site [active] 882097005642 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 882097005643 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 882097005644 Dimer interface [polypeptide binding]; other site 882097005645 BRCT sequence motif; other site 882097005646 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 882097005647 Part of AAA domain; Region: AAA_19; pfam13245 882097005648 Family description; Region: UvrD_C_2; pfam13538 882097005649 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 882097005650 PcrB family; Region: PcrB; pfam01884 882097005651 substrate binding site [chemical binding]; other site 882097005652 putative active site [active] 882097005653 dimer interface [polypeptide binding]; other site 882097005654 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 882097005655 Na2 binding site [ion binding]; other site 882097005656 putative substrate binding site 1 [chemical binding]; other site 882097005657 Na binding site 1 [ion binding]; other site 882097005658 putative substrate binding site 2 [chemical binding]; other site 882097005659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 882097005660 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 882097005661 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 882097005662 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 882097005663 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 882097005664 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 882097005665 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 882097005666 purine monophosphate binding site [chemical binding]; other site 882097005667 dimer interface [polypeptide binding]; other site 882097005668 putative catalytic residues [active] 882097005669 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 882097005670 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 882097005671 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 882097005672 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 882097005673 active site 882097005674 substrate binding site [chemical binding]; other site 882097005675 cosubstrate binding site; other site 882097005676 catalytic site [active] 882097005677 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 882097005678 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 882097005679 dimerization interface [polypeptide binding]; other site 882097005680 putative ATP binding site [chemical binding]; other site 882097005681 amidophosphoribosyltransferase; Provisional; Region: PRK06781 882097005682 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 882097005683 active site 882097005684 tetramer interface [polypeptide binding]; other site 882097005685 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882097005686 active site 882097005687 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 882097005688 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 882097005689 dimerization interface [polypeptide binding]; other site 882097005690 ATP binding site [chemical binding]; other site 882097005691 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 882097005692 dimerization interface [polypeptide binding]; other site 882097005693 ATP binding site [chemical binding]; other site 882097005694 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 882097005695 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 882097005696 putative active site [active] 882097005697 catalytic triad [active] 882097005698 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 882097005699 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 882097005700 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 882097005701 ATP binding site [chemical binding]; other site 882097005702 active site 882097005703 substrate binding site [chemical binding]; other site 882097005704 adenylosuccinate lyase; Provisional; Region: PRK07492 882097005705 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 882097005706 tetramer interface [polypeptide binding]; other site 882097005707 active site 882097005708 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 882097005709 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 882097005710 NAD binding site [chemical binding]; other site 882097005711 ATP-grasp domain; Region: ATP-grasp; pfam02222 882097005712 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 882097005713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 882097005714 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882097005715 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 882097005716 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882097005717 Zn2+ binding site [ion binding]; other site 882097005718 Mg2+ binding site [ion binding]; other site 882097005719 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 882097005720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 882097005721 Walker A/P-loop; other site 882097005722 ATP binding site [chemical binding]; other site 882097005723 Q-loop/lid; other site 882097005724 ABC transporter signature motif; other site 882097005725 Walker B; other site 882097005726 D-loop; other site 882097005727 H-loop/switch region; other site 882097005728 peptidase T; Region: peptidase-T; TIGR01882 882097005729 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 882097005730 metal binding site [ion binding]; metal-binding site 882097005731 dimer interface [polypeptide binding]; other site 882097005732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 882097005733 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 882097005734 active site 882097005735 putative catalytic site [active] 882097005736 DNA binding site [nucleotide binding] 882097005737 putative phosphate binding site [ion binding]; other site 882097005738 metal binding site A [ion binding]; metal-binding site 882097005739 AP binding site [nucleotide binding]; other site 882097005740 metal binding site B [ion binding]; metal-binding site 882097005741 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 882097005742 23S rRNA binding site [nucleotide binding]; other site 882097005743 L21 binding site [polypeptide binding]; other site 882097005744 L13 binding site [polypeptide binding]; other site 882097005745 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 882097005746 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 882097005747 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 882097005748 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 882097005749 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 882097005750 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 882097005751 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 882097005752 active site 882097005753 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 882097005754 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 882097005755 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 882097005756 DNA binding residues [nucleotide binding] 882097005757 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 882097005758 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 882097005759 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882097005760 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 882097005761 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 882097005762 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 882097005763 RimM N-terminal domain; Region: RimM; pfam01782 882097005764 PRC-barrel domain; Region: PRC; pfam05239 882097005765 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 882097005766 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 882097005767 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 882097005768 catalytic triad [active] 882097005769 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 882097005770 KH domain; Region: KH_4; pfam13083 882097005771 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 882097005772 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 882097005773 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 882097005774 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 882097005775 signal recognition particle protein; Provisional; Region: PRK10867 882097005776 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 882097005777 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 882097005778 P loop; other site 882097005779 GTP binding site [chemical binding]; other site 882097005780 Signal peptide binding domain; Region: SRP_SPB; pfam02978 882097005781 putative DNA-binding protein; Validated; Region: PRK00118 882097005782 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 882097005783 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 882097005784 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 882097005785 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 882097005786 P loop; other site 882097005787 GTP binding site [chemical binding]; other site 882097005788 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 882097005789 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 882097005790 Walker A/P-loop; other site 882097005791 ATP binding site [chemical binding]; other site 882097005792 Q-loop/lid; other site 882097005793 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 882097005794 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 882097005795 linker region; other site 882097005796 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 882097005797 ABC transporter signature motif; other site 882097005798 Walker B; other site 882097005799 D-loop; other site 882097005800 H-loop/switch region; other site 882097005801 ribonuclease III; Reviewed; Region: rnc; PRK00102 882097005802 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 882097005803 dimerization interface [polypeptide binding]; other site 882097005804 active site 882097005805 metal binding site [ion binding]; metal-binding site 882097005806 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 882097005807 dsRNA binding site [nucleotide binding]; other site 882097005808 acyl carrier protein; Provisional; Region: acpP; PRK00982 882097005809 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 882097005810 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 882097005811 NAD(P) binding site [chemical binding]; other site 882097005812 homotetramer interface [polypeptide binding]; other site 882097005813 homodimer interface [polypeptide binding]; other site 882097005814 active site 882097005815 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 882097005816 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 882097005817 putative phosphate acyltransferase; Provisional; Region: PRK05331 882097005818 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 882097005819 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 882097005820 active site 2 [active] 882097005821 active site 1 [active] 882097005822 Y-family of DNA polymerases; Region: PolY; cl12025 882097005823 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 882097005824 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 882097005825 generic binding surface II; other site 882097005826 ssDNA binding site; other site 882097005827 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882097005828 ATP binding site [chemical binding]; other site 882097005829 putative Mg++ binding site [ion binding]; other site 882097005830 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882097005831 nucleotide binding region [chemical binding]; other site 882097005832 ATP-binding site [chemical binding]; other site 882097005833 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 882097005834 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 882097005835 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 882097005836 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 882097005837 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 882097005838 putative L-serine binding site [chemical binding]; other site 882097005839 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 882097005840 DAK2 domain; Region: Dak2; pfam02734 882097005841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 882097005842 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 882097005843 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 882097005844 Thiamine pyrophosphokinase; Region: TPK; cd07995 882097005845 active site 882097005846 dimerization interface [polypeptide binding]; other site 882097005847 thiamine binding site [chemical binding]; other site 882097005848 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 882097005849 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 882097005850 substrate binding site [chemical binding]; other site 882097005851 hexamer interface [polypeptide binding]; other site 882097005852 metal binding site [ion binding]; metal-binding site 882097005853 GTPase RsgA; Reviewed; Region: PRK00098 882097005854 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 882097005855 RNA binding site [nucleotide binding]; other site 882097005856 homodimer interface [polypeptide binding]; other site 882097005857 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 882097005858 GTPase/Zn-binding domain interface [polypeptide binding]; other site 882097005859 GTP/Mg2+ binding site [chemical binding]; other site 882097005860 G4 box; other site 882097005861 G1 box; other site 882097005862 Switch I region; other site 882097005863 G2 box; other site 882097005864 G3 box; other site 882097005865 Switch II region; other site 882097005866 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 882097005867 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 882097005868 active site 882097005869 ATP binding site [chemical binding]; other site 882097005870 substrate binding site [chemical binding]; other site 882097005871 activation loop (A-loop); other site 882097005872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 882097005873 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 882097005874 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 882097005875 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 882097005876 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 882097005877 Protein phosphatase 2C; Region: PP2C; pfam00481 882097005878 active site 882097005879 16S rRNA methyltransferase B; Provisional; Region: PRK14902 882097005880 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 882097005881 putative RNA binding site [nucleotide binding]; other site 882097005882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097005883 S-adenosylmethionine binding site [chemical binding]; other site 882097005884 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 882097005885 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 882097005886 putative active site [active] 882097005887 substrate binding site [chemical binding]; other site 882097005888 putative cosubstrate binding site; other site 882097005889 catalytic site [active] 882097005890 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 882097005891 substrate binding site [chemical binding]; other site 882097005892 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 882097005893 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882097005894 ATP binding site [chemical binding]; other site 882097005895 putative Mg++ binding site [ion binding]; other site 882097005896 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882097005897 ATP-binding site [chemical binding]; other site 882097005898 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 882097005899 Flavoprotein; Region: Flavoprotein; pfam02441 882097005900 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 882097005901 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 882097005902 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 882097005903 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 882097005904 catalytic site [active] 882097005905 G-X2-G-X-G-K; other site 882097005906 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 882097005907 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 882097005908 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 882097005909 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 882097005910 Domain of unknown function (DUF814); Region: DUF814; pfam05670 882097005911 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 882097005912 putative NAD(P) binding site [chemical binding]; other site 882097005913 homodimer interface [polypeptide binding]; other site 882097005914 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882097005915 active site 882097005916 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 882097005917 active site 882097005918 dimer interface [polypeptide binding]; other site 882097005919 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 882097005920 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 882097005921 heterodimer interface [polypeptide binding]; other site 882097005922 active site 882097005923 FMN binding site [chemical binding]; other site 882097005924 homodimer interface [polypeptide binding]; other site 882097005925 substrate binding site [chemical binding]; other site 882097005926 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 882097005927 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 882097005928 FAD binding pocket [chemical binding]; other site 882097005929 FAD binding motif [chemical binding]; other site 882097005930 phosphate binding motif [ion binding]; other site 882097005931 beta-alpha-beta structure motif; other site 882097005932 NAD binding pocket [chemical binding]; other site 882097005933 Iron coordination center [ion binding]; other site 882097005934 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 882097005935 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 882097005936 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 882097005937 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 882097005938 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 882097005939 ATP-grasp domain; Region: ATP-grasp_4; cl17255 882097005940 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 882097005941 IMP binding site; other site 882097005942 dimer interface [polypeptide binding]; other site 882097005943 interdomain contacts; other site 882097005944 partial ornithine binding site; other site 882097005945 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 882097005946 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 882097005947 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 882097005948 catalytic site [active] 882097005949 subunit interface [polypeptide binding]; other site 882097005950 dihydroorotase; Validated; Region: pyrC; PRK09357 882097005951 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 882097005952 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 882097005953 active site 882097005954 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 882097005955 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 882097005956 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 882097005957 uracil transporter; Provisional; Region: PRK10720 882097005958 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 882097005959 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882097005960 active site 882097005961 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882097005962 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 882097005963 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882097005964 RNA binding surface [nucleotide binding]; other site 882097005965 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 882097005966 active site 882097005967 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 882097005968 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 882097005969 Sulfate transporter family; Region: Sulfate_transp; pfam00916 882097005970 multidrug efflux protein; Reviewed; Region: PRK01766 882097005971 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 882097005972 cation binding site [ion binding]; other site 882097005973 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 882097005974 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 882097005975 metal binding site [ion binding]; metal-binding site 882097005976 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 882097005977 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882097005978 ABC-ATPase subunit interface; other site 882097005979 dimer interface [polypeptide binding]; other site 882097005980 putative PBP binding regions; other site 882097005981 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 882097005982 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 882097005983 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882097005984 MarR family; Region: MarR; pfam01047 882097005985 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 882097005986 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 882097005987 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 882097005988 protein binding site [polypeptide binding]; other site 882097005989 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 882097005990 Catalytic dyad [active] 882097005991 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 882097005992 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 882097005993 metal-binding site [ion binding] 882097005994 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 882097005995 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 882097005996 metal-binding site [ion binding] 882097005997 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882097005998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097005999 motif II; other site 882097006000 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 882097006001 putative homodimer interface [polypeptide binding]; other site 882097006002 putative homotetramer interface [polypeptide binding]; other site 882097006003 putative allosteric switch controlling residues; other site 882097006004 putative metal binding site [ion binding]; other site 882097006005 putative homodimer-homodimer interface [polypeptide binding]; other site 882097006006 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 882097006007 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 882097006008 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 882097006009 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 882097006010 hypothetical protein; Provisional; Region: PRK13672 882097006011 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882097006012 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882097006013 methionine sulfoxide reductase B; Provisional; Region: PRK00222 882097006014 SelR domain; Region: SelR; pfam01641 882097006015 methionine sulfoxide reductase A; Provisional; Region: PRK14054 882097006016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 882097006017 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 882097006018 active site 882097006019 catalytic triad [active] 882097006020 oxyanion hole [active] 882097006021 EDD domain protein, DegV family; Region: DegV; TIGR00762 882097006022 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 882097006023 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 882097006024 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 882097006025 HTH domain; Region: HTH_11; pfam08279 882097006026 FOG: CBS domain [General function prediction only]; Region: COG0517 882097006027 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 882097006028 PEP synthetase regulatory protein; Provisional; Region: PRK05339 882097006029 pyruvate phosphate dikinase; Provisional; Region: PRK09279 882097006030 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 882097006031 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 882097006032 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 882097006033 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882097006034 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 882097006035 Predicted membrane protein [Function unknown]; Region: COG4129 882097006036 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 882097006037 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 882097006038 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 882097006039 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 882097006040 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 882097006041 active site 882097006042 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 882097006043 substrate binding site [chemical binding]; other site 882097006044 metal binding site [ion binding]; metal-binding site 882097006045 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 882097006046 Methyltransferase domain; Region: Methyltransf_18; pfam12847 882097006047 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 882097006048 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 882097006049 folate binding site [chemical binding]; other site 882097006050 NADP+ binding site [chemical binding]; other site 882097006051 thymidylate synthase; Region: thym_sym; TIGR03284 882097006052 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 882097006053 dimerization interface [polypeptide binding]; other site 882097006054 active site 882097006055 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 882097006056 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 882097006057 Walker A/P-loop; other site 882097006058 ATP binding site [chemical binding]; other site 882097006059 Q-loop/lid; other site 882097006060 ABC transporter signature motif; other site 882097006061 Walker B; other site 882097006062 D-loop; other site 882097006063 H-loop/switch region; other site 882097006064 ABC transporter; Region: ABC_tran_2; pfam12848 882097006065 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882097006066 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 882097006067 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 882097006068 Potassium binding sites [ion binding]; other site 882097006069 Cesium cation binding sites [ion binding]; other site 882097006070 manganese transport transcriptional regulator; Provisional; Region: PRK03902 882097006071 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 882097006072 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 882097006073 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 882097006074 DNA-binding site [nucleotide binding]; DNA binding site 882097006075 RNA-binding motif; other site 882097006076 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 882097006077 RNA/DNA hybrid binding site [nucleotide binding]; other site 882097006078 active site 882097006079 5'-3' exonuclease; Region: 53EXOc; smart00475 882097006080 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 882097006081 active site 882097006082 metal binding site 1 [ion binding]; metal-binding site 882097006083 putative 5' ssDNA interaction site; other site 882097006084 metal binding site 3; metal-binding site 882097006085 metal binding site 2 [ion binding]; metal-binding site 882097006086 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 882097006087 putative DNA binding site [nucleotide binding]; other site 882097006088 putative metal binding site [ion binding]; other site 882097006089 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 882097006090 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 882097006091 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 882097006092 putative active site [active] 882097006093 xanthine permease; Region: pbuX; TIGR03173 882097006094 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882097006095 active site 882097006096 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 882097006097 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 882097006098 active site 882097006099 Zn binding site [ion binding]; other site 882097006100 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 882097006101 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 882097006102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 882097006103 cell division protein GpsB; Provisional; Region: PRK14127 882097006104 DivIVA domain; Region: DivI1A_domain; TIGR03544 882097006105 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 882097006106 hypothetical protein; Provisional; Region: PRK13660 882097006107 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 882097006108 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 882097006109 Transglycosylase; Region: Transgly; pfam00912 882097006110 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 882097006111 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 882097006112 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 882097006113 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 882097006114 minor groove reading motif; other site 882097006115 helix-hairpin-helix signature motif; other site 882097006116 substrate binding pocket [chemical binding]; other site 882097006117 active site 882097006118 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 882097006119 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 882097006120 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 882097006121 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 882097006122 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 882097006123 putative dimer interface [polypeptide binding]; other site 882097006124 putative anticodon binding site; other site 882097006125 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 882097006126 homodimer interface [polypeptide binding]; other site 882097006127 motif 1; other site 882097006128 motif 2; other site 882097006129 active site 882097006130 motif 3; other site 882097006131 aspartate aminotransferase; Provisional; Region: PRK05764 882097006132 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882097006133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097006134 homodimer interface [polypeptide binding]; other site 882097006135 catalytic residue [active] 882097006136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 882097006137 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 882097006138 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 882097006139 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 882097006140 active site 882097006141 catalytic site [active] 882097006142 substrate binding site [chemical binding]; other site 882097006143 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 882097006144 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 882097006145 putative Mg++ binding site [ion binding]; other site 882097006146 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 882097006147 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 882097006148 tetramerization interface [polypeptide binding]; other site 882097006149 active site 882097006150 pantoate--beta-alanine ligase; Region: panC; TIGR00018 882097006151 Pantoate-beta-alanine ligase; Region: PanC; cd00560 882097006152 active site 882097006153 ATP-binding site [chemical binding]; other site 882097006154 pantoate-binding site; other site 882097006155 HXXH motif; other site 882097006156 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 882097006157 active site 882097006158 oligomerization interface [polypeptide binding]; other site 882097006159 metal binding site [ion binding]; metal-binding site 882097006160 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882097006161 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 882097006162 catalytic residues [active] 882097006163 Biotin operon repressor [Transcription]; Region: BirA; COG1654 882097006164 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 882097006165 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 882097006166 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 882097006167 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 882097006168 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 882097006169 active site 882097006170 NTP binding site [chemical binding]; other site 882097006171 metal binding triad [ion binding]; metal-binding site 882097006172 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 882097006173 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 882097006174 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 882097006175 active site 882097006176 dimer interfaces [polypeptide binding]; other site 882097006177 catalytic residues [active] 882097006178 dihydrodipicolinate reductase; Provisional; Region: PRK00048 882097006179 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 882097006180 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 882097006181 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 882097006182 homodimer interface [polypeptide binding]; other site 882097006183 metal binding site [ion binding]; metal-binding site 882097006184 Uncharacterized conserved protein [Function unknown]; Region: COG1284 882097006185 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882097006186 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882097006187 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882097006188 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 882097006189 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 882097006190 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 882097006191 metal binding site [ion binding]; metal-binding site 882097006192 active site 882097006193 I-site; other site 882097006194 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 882097006195 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 882097006196 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 882097006197 metal binding site [ion binding]; metal-binding site 882097006198 active site 882097006199 I-site; other site 882097006200 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 882097006201 malate dehydrogenase; Provisional; Region: PRK13529 882097006202 Malic enzyme, N-terminal domain; Region: malic; pfam00390 882097006203 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 882097006204 NAD(P) binding pocket [chemical binding]; other site 882097006205 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 882097006206 Beta-lactamase; Region: Beta-lactamase; pfam00144 882097006207 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 882097006208 Pyruvate formate lyase 1; Region: PFL1; cd01678 882097006209 coenzyme A binding site [chemical binding]; other site 882097006210 active site 882097006211 catalytic residues [active] 882097006212 glycine loop; other site 882097006213 HI0933-like protein; Region: HI0933_like; pfam03486 882097006214 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882097006215 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 882097006216 Predicted membrane protein [Function unknown]; Region: COG4347 882097006217 hypothetical protein; Provisional; Region: PRK03636 882097006218 UPF0302 domain; Region: UPF0302; pfam08864 882097006219 IDEAL domain; Region: IDEAL; pfam08858 882097006220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 882097006221 binding surface 882097006222 TPR motif; other site 882097006223 TPR repeat; Region: TPR_11; pfam13414 882097006224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882097006225 binding surface 882097006226 TPR motif; other site 882097006227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 882097006228 binding surface 882097006229 TPR motif; other site 882097006230 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 882097006231 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 882097006232 hinge; other site 882097006233 active site 882097006234 prephenate dehydrogenase; Validated; Region: PRK06545 882097006235 prephenate dehydrogenase; Validated; Region: PRK08507 882097006236 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 882097006237 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 882097006238 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882097006239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097006240 homodimer interface [polypeptide binding]; other site 882097006241 catalytic residue [active] 882097006242 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 882097006243 homotrimer interaction site [polypeptide binding]; other site 882097006244 active site 882097006245 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 882097006246 active site 882097006247 dimer interface [polypeptide binding]; other site 882097006248 metal binding site [ion binding]; metal-binding site 882097006249 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 882097006250 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 882097006251 Tetramer interface [polypeptide binding]; other site 882097006252 active site 882097006253 FMN-binding site [chemical binding]; other site 882097006254 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 882097006255 active site 882097006256 multimer interface [polypeptide binding]; other site 882097006257 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 882097006258 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 882097006259 substrate binding pocket [chemical binding]; other site 882097006260 chain length determination region; other site 882097006261 substrate-Mg2+ binding site; other site 882097006262 catalytic residues [active] 882097006263 aspartate-rich region 1; other site 882097006264 active site lid residues [active] 882097006265 aspartate-rich region 2; other site 882097006266 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 882097006267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097006268 S-adenosylmethionine binding site [chemical binding]; other site 882097006269 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 882097006270 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 882097006271 homodecamer interface [polypeptide binding]; other site 882097006272 GTP cyclohydrolase I; Provisional; Region: PLN03044 882097006273 active site 882097006274 putative catalytic site residues [active] 882097006275 zinc binding site [ion binding]; other site 882097006276 GTP-CH-I/GFRP interaction surface; other site 882097006277 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 882097006278 IHF dimer interface [polypeptide binding]; other site 882097006279 IHF - DNA interface [nucleotide binding]; other site 882097006280 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 882097006281 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 882097006282 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 882097006283 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 882097006284 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 882097006285 GTP-binding protein Der; Reviewed; Region: PRK00093 882097006286 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 882097006287 G1 box; other site 882097006288 GTP/Mg2+ binding site [chemical binding]; other site 882097006289 Switch I region; other site 882097006290 G2 box; other site 882097006291 Switch II region; other site 882097006292 G3 box; other site 882097006293 G4 box; other site 882097006294 G5 box; other site 882097006295 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 882097006296 G1 box; other site 882097006297 GTP/Mg2+ binding site [chemical binding]; other site 882097006298 Switch I region; other site 882097006299 G2 box; other site 882097006300 G3 box; other site 882097006301 Switch II region; other site 882097006302 G4 box; other site 882097006303 G5 box; other site 882097006304 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 882097006305 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 882097006306 RNA binding site [nucleotide binding]; other site 882097006307 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 882097006308 RNA binding site [nucleotide binding]; other site 882097006309 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 882097006310 RNA binding site [nucleotide binding]; other site 882097006311 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 882097006312 RNA binding site [nucleotide binding]; other site 882097006313 cytidylate kinase; Provisional; Region: cmk; PRK00023 882097006314 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 882097006315 CMP-binding site; other site 882097006316 The sites determining sugar specificity; other site 882097006317 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 882097006318 active site 882097006319 homotetramer interface [polypeptide binding]; other site 882097006320 homodimer interface [polypeptide binding]; other site 882097006321 DEAD-like helicases superfamily; Region: DEXDc; smart00487 882097006322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882097006323 ATP binding site [chemical binding]; other site 882097006324 putative Mg++ binding site [ion binding]; other site 882097006325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882097006326 nucleotide binding region [chemical binding]; other site 882097006327 ATP-binding site [chemical binding]; other site 882097006328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 882097006329 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 882097006330 Predicted membrane protein [Function unknown]; Region: COG3601 882097006331 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 882097006332 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 882097006333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 882097006334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882097006335 dimerization interface [polypeptide binding]; other site 882097006336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882097006337 dimer interface [polypeptide binding]; other site 882097006338 phosphorylation site [posttranslational modification] 882097006339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097006340 ATP binding site [chemical binding]; other site 882097006341 Mg2+ binding site [ion binding]; other site 882097006342 G-X-G motif; other site 882097006343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882097006344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097006345 active site 882097006346 phosphorylation site [posttranslational modification] 882097006347 intermolecular recognition site; other site 882097006348 dimerization interface [polypeptide binding]; other site 882097006349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882097006350 DNA binding site [nucleotide binding] 882097006351 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 882097006352 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882097006353 RNA binding surface [nucleotide binding]; other site 882097006354 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 882097006355 active site 882097006356 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 882097006357 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 882097006358 diaminopimelate decarboxylase; Region: lysA; TIGR01048 882097006359 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 882097006360 active site 882097006361 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 882097006362 substrate binding site [chemical binding]; other site 882097006363 catalytic residues [active] 882097006364 dimer interface [polypeptide binding]; other site 882097006365 purine nucleoside phosphorylase; Provisional; Region: PRK08202 882097006366 phosphopentomutase; Provisional; Region: PRK05362 882097006367 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 882097006368 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 882097006369 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 882097006370 active site 882097006371 Int/Topo IB signature motif; other site 882097006372 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 882097006373 metal binding site 2 [ion binding]; metal-binding site 882097006374 putative DNA binding helix; other site 882097006375 metal binding site 1 [ion binding]; metal-binding site 882097006376 dimer interface [polypeptide binding]; other site 882097006377 structural Zn2+ binding site [ion binding]; other site 882097006378 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 882097006379 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882097006380 ABC-ATPase subunit interface; other site 882097006381 dimer interface [polypeptide binding]; other site 882097006382 putative PBP binding regions; other site 882097006383 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 882097006384 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882097006385 ABC-ATPase subunit interface; other site 882097006386 dimer interface [polypeptide binding]; other site 882097006387 putative PBP binding regions; other site 882097006388 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 882097006389 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 882097006390 putative ligand binding residues [chemical binding]; other site 882097006391 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 882097006392 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 882097006393 Walker A/P-loop; other site 882097006394 ATP binding site [chemical binding]; other site 882097006395 Q-loop/lid; other site 882097006396 ABC transporter signature motif; other site 882097006397 Walker B; other site 882097006398 D-loop; other site 882097006399 H-loop/switch region; other site 882097006400 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 882097006401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882097006402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882097006403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882097006404 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 882097006405 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 882097006406 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882097006407 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882097006408 Walker A/P-loop; other site 882097006409 ATP binding site [chemical binding]; other site 882097006410 Q-loop/lid; other site 882097006411 ABC transporter signature motif; other site 882097006412 Walker B; other site 882097006413 D-loop; other site 882097006414 H-loop/switch region; other site 882097006415 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 882097006416 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 882097006417 dimer interface [polypeptide binding]; other site 882097006418 ADP-ribose binding site [chemical binding]; other site 882097006419 active site 882097006420 nudix motif; other site 882097006421 metal binding site [ion binding]; metal-binding site 882097006422 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 882097006423 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 882097006424 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 882097006425 active site 882097006426 DNA polymerase IV; Validated; Region: PRK02406 882097006427 DNA binding site [nucleotide binding] 882097006428 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 882097006429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 882097006430 NAD(P) binding site [chemical binding]; other site 882097006431 active site 882097006432 ribonuclease Z; Region: RNase_Z; TIGR02651 882097006433 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 882097006434 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 882097006435 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 882097006436 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 882097006437 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 882097006438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097006439 Coenzyme A binding pocket [chemical binding]; other site 882097006440 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 882097006441 6-phosphogluconate dehydratase; Region: edd; TIGR01196 882097006442 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 882097006443 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 882097006444 PYR/PP interface [polypeptide binding]; other site 882097006445 dimer interface [polypeptide binding]; other site 882097006446 TPP binding site [chemical binding]; other site 882097006447 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 882097006448 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 882097006449 TPP-binding site [chemical binding]; other site 882097006450 dimer interface [polypeptide binding]; other site 882097006451 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 882097006452 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 882097006453 putative valine binding site [chemical binding]; other site 882097006454 dimer interface [polypeptide binding]; other site 882097006455 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 882097006456 ketol-acid reductoisomerase; Provisional; Region: PRK05479 882097006457 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 882097006458 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 882097006459 2-isopropylmalate synthase; Validated; Region: PRK00915 882097006460 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 882097006461 active site 882097006462 catalytic residues [active] 882097006463 metal binding site [ion binding]; metal-binding site 882097006464 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 882097006465 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 882097006466 tartrate dehydrogenase; Region: TTC; TIGR02089 882097006467 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 882097006468 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 882097006469 substrate binding site [chemical binding]; other site 882097006470 ligand binding site [chemical binding]; other site 882097006471 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 882097006472 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 882097006473 substrate binding site [chemical binding]; other site 882097006474 threonine dehydratase; Validated; Region: PRK08639 882097006475 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 882097006476 tetramer interface [polypeptide binding]; other site 882097006477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097006478 catalytic residue [active] 882097006479 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 882097006480 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 882097006481 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 882097006482 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 882097006483 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 882097006484 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 882097006485 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882097006486 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882097006487 DNA binding site [nucleotide binding] 882097006488 domain linker motif; other site 882097006489 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 882097006490 dimerization interface [polypeptide binding]; other site 882097006491 ligand binding site [chemical binding]; other site 882097006492 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 882097006493 intersubunit interface [polypeptide binding]; other site 882097006494 active site 882097006495 catalytic residue [active] 882097006496 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 882097006497 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 882097006498 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 882097006499 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882097006500 active pocket/dimerization site; other site 882097006501 active site 882097006502 phosphorylation site [posttranslational modification] 882097006503 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 882097006504 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 882097006505 putative active site [active] 882097006506 SIS domain; Region: SIS; pfam01380 882097006507 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449 882097006508 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 882097006509 dimer interface [polypeptide binding]; other site 882097006510 active site 882097006511 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 882097006512 dimer interface [polypeptide binding]; other site 882097006513 active site 882097006514 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 882097006515 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 882097006516 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 882097006517 active site 882097006518 phosphorylation site [posttranslational modification] 882097006519 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882097006520 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097006521 DNA-binding site [nucleotide binding]; DNA binding site 882097006522 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 882097006523 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882097006524 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097006525 DNA-binding site [nucleotide binding]; DNA binding site 882097006526 UTRA domain; Region: UTRA; pfam07702 882097006527 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882097006528 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882097006529 active site 882097006530 catalytic tetrad [active] 882097006531 acetolactate synthase; Reviewed; Region: PRK08617 882097006532 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 882097006533 PYR/PP interface [polypeptide binding]; other site 882097006534 dimer interface [polypeptide binding]; other site 882097006535 TPP binding site [chemical binding]; other site 882097006536 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 882097006537 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 882097006538 TPP-binding site [chemical binding]; other site 882097006539 dimer interface [polypeptide binding]; other site 882097006540 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882097006541 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 882097006542 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 882097006543 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882097006544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097006545 dimer interface [polypeptide binding]; other site 882097006546 conserved gate region; other site 882097006547 ABC-ATPase subunit interface; other site 882097006548 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 882097006549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097006550 dimer interface [polypeptide binding]; other site 882097006551 conserved gate region; other site 882097006552 ABC-ATPase subunit interface; other site 882097006553 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 882097006554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097006555 active site 882097006556 phosphorylation site [posttranslational modification] 882097006557 intermolecular recognition site; other site 882097006558 dimerization interface [polypeptide binding]; other site 882097006559 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882097006560 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 882097006561 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882097006562 dimerization interface [polypeptide binding]; other site 882097006563 Histidine kinase; Region: His_kinase; pfam06580 882097006564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097006565 ATP binding site [chemical binding]; other site 882097006566 Mg2+ binding site [ion binding]; other site 882097006567 G-X-G motif; other site 882097006568 Predicted integral membrane protein [Function unknown]; Region: COG5578 882097006569 Uncharacterized conserved protein [Function unknown]; Region: COG3538 882097006570 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 882097006571 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 882097006572 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 882097006573 active site 882097006574 metal binding site [ion binding]; metal-binding site 882097006575 homodimer interface [polypeptide binding]; other site 882097006576 catalytic site [active] 882097006577 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 882097006578 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 882097006579 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 882097006580 active site 882097006581 catalytic site [active] 882097006582 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 882097006583 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 882097006584 DNA-binding site [nucleotide binding]; DNA binding site 882097006585 RNA-binding motif; other site 882097006586 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 882097006587 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 882097006588 active site 882097006589 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 882097006590 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 882097006591 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 882097006592 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 882097006593 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 882097006594 HIGH motif; other site 882097006595 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 882097006596 active site 882097006597 KMSKS motif; other site 882097006598 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 882097006599 tRNA binding surface [nucleotide binding]; other site 882097006600 anticodon binding site; other site 882097006601 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 882097006602 DivIVA protein; Region: DivIVA; pfam05103 882097006603 DivIVA domain; Region: DivI1A_domain; TIGR03544 882097006604 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 882097006605 HTH domain; Region: HTH_11; pfam08279 882097006606 3H domain; Region: 3H; pfam02829 882097006607 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 882097006608 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 882097006609 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882097006610 catalytic residue [active] 882097006611 L-aspartate oxidase; Provisional; Region: PRK08071 882097006612 L-aspartate oxidase; Provisional; Region: PRK06175 882097006613 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 882097006614 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 882097006615 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 882097006616 dimerization interface [polypeptide binding]; other site 882097006617 active site 882097006618 quinolinate synthetase; Provisional; Region: PRK09375 882097006619 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 882097006620 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882097006621 RNA binding surface [nucleotide binding]; other site 882097006622 YGGT family; Region: YGGT; pfam02325 882097006623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 882097006624 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 882097006625 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 882097006626 catalytic residue [active] 882097006627 cell division protein FtsZ; Validated; Region: PRK09330 882097006628 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 882097006629 nucleotide binding site [chemical binding]; other site 882097006630 SulA interaction site; other site 882097006631 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 882097006632 Cell division protein FtsA; Region: FtsA; smart00842 882097006633 Cell division protein FtsA; Region: FtsA; pfam14450 882097006634 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 882097006635 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 882097006636 Cell division protein FtsQ; Region: FtsQ; pfam03799 882097006637 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 882097006638 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 882097006639 active site 882097006640 homodimer interface [polypeptide binding]; other site 882097006641 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 882097006642 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 882097006643 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 882097006644 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 882097006645 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 882097006646 Mg++ binding site [ion binding]; other site 882097006647 putative catalytic motif [active] 882097006648 putative substrate binding site [chemical binding]; other site 882097006649 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 882097006650 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 882097006651 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 882097006652 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 882097006653 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 882097006654 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 882097006655 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 882097006656 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 882097006657 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 882097006658 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 882097006659 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 882097006660 MraW methylase family; Region: Methyltransf_5; pfam01795 882097006661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 882097006662 MraZ protein; Region: MraZ; pfam02381 882097006663 MraZ protein; Region: MraZ; pfam02381 882097006664 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882097006665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097006666 putative substrate translocation pore; other site 882097006667 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 882097006668 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 882097006669 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 882097006670 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 882097006671 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 882097006672 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 882097006673 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 882097006674 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 882097006675 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 882097006676 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 882097006677 hypothetical protein; Provisional; Region: PRK13670 882097006678 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 882097006679 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 882097006680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097006681 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14267 882097006682 Walker A/P-loop; other site 882097006683 ATP binding site [chemical binding]; other site 882097006684 Q-loop/lid; other site 882097006685 ABC transporter signature motif; other site 882097006686 Walker B; other site 882097006687 D-loop; other site 882097006688 H-loop/switch region; other site 882097006689 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 882097006690 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 882097006691 protein binding site [polypeptide binding]; other site 882097006692 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 882097006693 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 882097006694 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 882097006695 active site 882097006696 (T/H)XGH motif; other site 882097006697 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 882097006698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097006699 S-adenosylmethionine binding site [chemical binding]; other site 882097006700 hypothetical protein; Provisional; Region: PRK02886 882097006701 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 882097006702 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 882097006703 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 882097006704 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 882097006705 UbiA prenyltransferase family; Region: UbiA; pfam01040 882097006706 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 882097006707 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 882097006708 Ion transport protein; Region: Ion_trans; pfam00520 882097006709 Ion channel; Region: Ion_trans_2; pfam07885 882097006710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 882097006711 MOSC domain; Region: MOSC; pfam03473 882097006712 3-alpha domain; Region: 3-alpha; pfam03475 882097006713 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 882097006714 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 882097006715 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 882097006716 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 882097006717 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 882097006718 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 882097006719 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 882097006720 active site 882097006721 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 882097006722 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 882097006723 ring oligomerisation interface [polypeptide binding]; other site 882097006724 ATP/Mg binding site [chemical binding]; other site 882097006725 stacking interactions; other site 882097006726 hinge regions; other site 882097006727 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 882097006728 oligomerisation interface [polypeptide binding]; other site 882097006729 mobile loop; other site 882097006730 roof hairpin; other site 882097006731 CAAX protease self-immunity; Region: Abi; pfam02517 882097006732 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 882097006733 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 882097006734 CoA binding domain; Region: CoA_binding; pfam02629 882097006735 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 882097006736 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882097006737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097006738 Q-loop/lid; other site 882097006739 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882097006740 ABC transporter signature motif; other site 882097006741 Walker B; other site 882097006742 D-loop; other site 882097006743 ABC transporter; Region: ABC_tran_2; pfam12848 882097006744 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882097006745 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882097006746 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 882097006747 UGMP family protein; Validated; Region: PRK09604 882097006748 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 882097006749 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 882097006750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097006751 Coenzyme A binding pocket [chemical binding]; other site 882097006752 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 882097006753 Glycoprotease family; Region: Peptidase_M22; pfam00814 882097006754 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 882097006755 camphor resistance protein CrcB; Provisional; Region: PRK14214 882097006756 camphor resistance protein CrcB; Provisional; Region: PRK14231 882097006757 Uncharacterized conserved protein [Function unknown]; Region: COG4832 882097006758 Phosphotransferase enzyme family; Region: APH; pfam01636 882097006759 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 882097006760 active site 882097006761 substrate binding site [chemical binding]; other site 882097006762 ATP binding site [chemical binding]; other site 882097006763 Cna protein B-type domain; Region: Cna_B; pfam05738 882097006764 Cna protein B-type domain; Region: Cna_B; pfam05738 882097006765 Cna protein B-type domain; Region: Cna_B; pfam05738 882097006766 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882097006767 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097006768 non-specific DNA binding site [nucleotide binding]; other site 882097006769 salt bridge; other site 882097006770 sequence-specific DNA binding site [nucleotide binding]; other site 882097006771 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 882097006772 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 882097006773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882097006774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882097006775 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 882097006776 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 882097006777 substrate binding pocket [chemical binding]; other site 882097006778 argininosuccinate synthase; Provisional; Region: PRK13820 882097006779 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 882097006780 ANP binding site [chemical binding]; other site 882097006781 Substrate Binding Site II [chemical binding]; other site 882097006782 Substrate Binding Site I [chemical binding]; other site 882097006783 argininosuccinate lyase; Provisional; Region: PRK00855 882097006784 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 882097006785 active sites [active] 882097006786 tetramer interface [polypeptide binding]; other site 882097006787 BCCT family transporter; Region: BCCT; pfam02028 882097006788 hypothetical protein; Provisional; Region: PRK06357 882097006789 active site 882097006790 intersubunit interface [polypeptide binding]; other site 882097006791 Zn2+ binding site [ion binding]; other site 882097006792 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 882097006793 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 882097006794 putative substrate binding site [chemical binding]; other site 882097006795 putative ATP binding site [chemical binding]; other site 882097006796 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 882097006797 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 882097006798 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 882097006799 active site 882097006800 P-loop; other site 882097006801 phosphorylation site [posttranslational modification] 882097006802 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097006803 active site 882097006804 phosphorylation site [posttranslational modification] 882097006805 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882097006806 PRD domain; Region: PRD; pfam00874 882097006807 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882097006808 active site 882097006809 P-loop; other site 882097006810 phosphorylation site [posttranslational modification] 882097006811 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 882097006812 active site 882097006813 phosphorylation site [posttranslational modification] 882097006814 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 882097006815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097006816 DNA-binding site [nucleotide binding]; DNA binding site 882097006817 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882097006818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097006819 homodimer interface [polypeptide binding]; other site 882097006820 catalytic residue [active] 882097006821 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 882097006822 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 882097006823 active site 882097006824 multimer interface [polypeptide binding]; other site 882097006825 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 882097006826 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 882097006827 predicted active site [active] 882097006828 catalytic triad [active] 882097006829 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 882097006830 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 882097006831 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 882097006832 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 882097006833 G1 box; other site 882097006834 GTP/Mg2+ binding site [chemical binding]; other site 882097006835 Switch I region; other site 882097006836 G2 box; other site 882097006837 G3 box; other site 882097006838 Switch II region; other site 882097006839 G4 box; other site 882097006840 G5 box; other site 882097006841 Nucleoside recognition; Region: Gate; pfam07670 882097006842 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 882097006843 Nucleoside recognition; Region: Gate; pfam07670 882097006844 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 882097006845 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 882097006846 putative active site [active] 882097006847 putative metal binding site [ion binding]; other site 882097006848 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882097006849 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 882097006850 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882097006851 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 882097006852 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 882097006853 active site 882097006854 dimer interface [polypeptide binding]; other site 882097006855 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 882097006856 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 882097006857 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 882097006858 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 882097006859 dimer interface [polypeptide binding]; other site 882097006860 FMN binding site [chemical binding]; other site 882097006861 NADPH bind site [chemical binding]; other site 882097006862 Helix-turn-helix domain; Region: HTH_17; pfam12728 882097006863 putative heme peroxidase; Provisional; Region: PRK12276 882097006864 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882097006865 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882097006866 Walker A/P-loop; other site 882097006867 ATP binding site [chemical binding]; other site 882097006868 Q-loop/lid; other site 882097006869 ABC transporter signature motif; other site 882097006870 Walker B; other site 882097006871 D-loop; other site 882097006872 H-loop/switch region; other site 882097006873 FtsX-like permease family; Region: FtsX; pfam02687 882097006874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097006875 Coenzyme A binding pocket [chemical binding]; other site 882097006876 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 882097006877 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 882097006878 active site 882097006879 substrate binding site [chemical binding]; other site 882097006880 metal binding site [ion binding]; metal-binding site 882097006881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 882097006882 YbbR-like protein; Region: YbbR; pfam07949 882097006883 YbbR-like protein; Region: YbbR; pfam07949 882097006884 YbbR-like protein; Region: YbbR; pfam07949 882097006885 Uncharacterized conserved protein [Function unknown]; Region: COG1624 882097006886 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 882097006887 maltose phosphorylase; Provisional; Region: PRK13807 882097006888 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 882097006889 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 882097006890 Predicted integral membrane protein [Function unknown]; Region: COG5521 882097006891 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882097006892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097006893 dimer interface [polypeptide binding]; other site 882097006894 conserved gate region; other site 882097006895 putative PBP binding loops; other site 882097006896 ABC-ATPase subunit interface; other site 882097006897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097006898 dimer interface [polypeptide binding]; other site 882097006899 conserved gate region; other site 882097006900 putative PBP binding loops; other site 882097006901 ABC-ATPase subunit interface; other site 882097006902 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 882097006903 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882097006904 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 882097006905 homodimer interface [polypeptide binding]; other site 882097006906 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 882097006907 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 882097006908 active site 882097006909 homodimer interface [polypeptide binding]; other site 882097006910 catalytic site [active] 882097006911 Amino acid permease; Region: AA_permease_2; pfam13520 882097006912 K+ potassium transporter; Region: K_trans; cl15781 882097006913 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097006914 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882097006915 ligand binding site [chemical binding]; other site 882097006916 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097006917 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 882097006918 ligand binding site [chemical binding]; other site 882097006919 flexible hinge region; other site 882097006920 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882097006921 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 882097006922 intersubunit interface [polypeptide binding]; other site 882097006923 active site 882097006924 zinc binding site [ion binding]; other site 882097006925 Na+ binding site [ion binding]; other site 882097006926 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 882097006927 intersubunit interface [polypeptide binding]; other site 882097006928 active site 882097006929 zinc binding site [ion binding]; other site 882097006930 Na+ binding site [ion binding]; other site 882097006931 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882097006932 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882097006933 active site 882097006934 P-loop; other site 882097006935 phosphorylation site [posttranslational modification] 882097006936 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097006937 active site 882097006938 phosphorylation site [posttranslational modification] 882097006939 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882097006940 HTH domain; Region: HTH_11; pfam08279 882097006941 Mga helix-turn-helix domain; Region: Mga; pfam05043 882097006942 PRD domain; Region: PRD; pfam00874 882097006943 PRD domain; Region: PRD; pfam00874 882097006944 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882097006945 active site 882097006946 P-loop; other site 882097006947 phosphorylation site [posttranslational modification] 882097006948 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 882097006949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097006950 Walker A/P-loop; other site 882097006951 ATP binding site [chemical binding]; other site 882097006952 Q-loop/lid; other site 882097006953 ABC transporter signature motif; other site 882097006954 Walker B; other site 882097006955 D-loop; other site 882097006956 H-loop/switch region; other site 882097006957 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 882097006958 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 882097006959 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 882097006960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097006961 Coenzyme A binding pocket [chemical binding]; other site 882097006962 Transcriptional regulators [Transcription]; Region: GntR; COG1802 882097006963 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 882097006964 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 882097006965 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882097006966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097006967 DNA-binding site [nucleotide binding]; DNA binding site 882097006968 UTRA domain; Region: UTRA; pfam07702 882097006969 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 882097006970 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 882097006971 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882097006972 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882097006973 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 882097006974 putative dimerization interface [polypeptide binding]; other site 882097006975 Predicted membrane protein [Function unknown]; Region: COG2855 882097006976 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 882097006977 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 882097006978 putative metal binding site [ion binding]; other site 882097006979 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 882097006980 homodimer interface [polypeptide binding]; other site 882097006981 chemical substrate binding site [chemical binding]; other site 882097006982 oligomer interface [polypeptide binding]; other site 882097006983 metal binding site [ion binding]; metal-binding site 882097006984 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882097006985 catalytic residues [active] 882097006986 flavodoxin; Provisional; Region: PRK09271 882097006987 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 882097006988 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 882097006989 dimer interface [polypeptide binding]; other site 882097006990 putative radical transfer pathway; other site 882097006991 diiron center [ion binding]; other site 882097006992 tyrosyl radical; other site 882097006993 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 882097006994 Class I ribonucleotide reductase; Region: RNR_I; cd01679 882097006995 active site 882097006996 dimer interface [polypeptide binding]; other site 882097006997 catalytic residues [active] 882097006998 effector binding site; other site 882097006999 R2 peptide binding site; other site 882097007000 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 882097007001 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 882097007002 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 882097007003 SCP-2 sterol transfer family; Region: SCP2; cl01225 882097007004 CsbD-like; Region: CsbD; cl17424 882097007005 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882097007006 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882097007007 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 882097007008 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 882097007009 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 882097007010 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 882097007011 conserved cys residue [active] 882097007012 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 882097007013 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882097007014 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882097007015 Cupin domain; Region: Cupin_2; pfam07883 882097007016 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882097007017 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882097007018 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097007019 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 882097007020 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097007021 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882097007022 ligand binding site [chemical binding]; other site 882097007023 flexible hinge region; other site 882097007024 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 882097007025 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882097007026 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882097007027 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 882097007028 dimer interface [polypeptide binding]; other site 882097007029 active site 882097007030 metal binding site [ion binding]; metal-binding site 882097007031 glutathione binding site [chemical binding]; other site 882097007032 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 882097007033 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 882097007034 FMN binding site [chemical binding]; other site 882097007035 substrate binding site [chemical binding]; other site 882097007036 putative catalytic residue [active] 882097007037 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 882097007038 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 882097007039 Coenzyme A transferase; Region: CoA_trans; smart00882 882097007040 Coenzyme A transferase; Region: CoA_trans; cl17247 882097007041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097007042 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 882097007043 Walker A motif; other site 882097007044 ATP binding site [chemical binding]; other site 882097007045 Walker B motif; other site 882097007046 arginine finger; other site 882097007047 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 882097007048 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 882097007049 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 882097007050 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 882097007051 metal binding site [ion binding]; metal-binding site 882097007052 active site 882097007053 I-site; other site 882097007054 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 882097007055 classical (c) SDRs; Region: SDR_c; cd05233 882097007056 NAD(P) binding site [chemical binding]; other site 882097007057 active site 882097007058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882097007059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882097007060 Tic20-like protein; Region: Tic20; pfam09685 882097007061 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 882097007062 Collagen binding domain; Region: Collagen_bind; pfam05737 882097007063 Cna protein B-type domain; Region: Cna_B; pfam05738 882097007064 Cna protein B-type domain; Region: Cna_B; pfam05738 882097007065 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 882097007066 Cna protein B-type domain; Region: Cna_B; pfam05738 882097007067 Cna protein B-type domain; Region: Cna_B; pfam05738 882097007068 Cna protein B-type domain; Region: Cna_B; pfam05738 882097007069 Cna protein B-type domain; Region: Cna_B; pfam05738 882097007070 Cna protein B-type domain; Region: Cna_B; pfam05738 882097007071 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097007072 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 882097007073 Cna protein B-type domain; Region: Cna_B; pfam05738 882097007074 Collagen binding domain; Region: Collagen_bind; pfam05737 882097007075 Cna protein B-type domain; Region: Cna_B; pfam05738 882097007076 Cna protein B-type domain; Region: Cna_B; pfam05738 882097007077 Cna protein B-type domain; Region: Cna_B; pfam05738 882097007078 Cna protein B-type domain; Region: Cna_B; pfam05738 882097007079 Cna protein B-type domain; Region: Cna_B; pfam05738 882097007080 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097007081 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097007082 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097007083 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882097007084 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 882097007085 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 882097007086 active site 882097007087 catalytic site [active] 882097007088 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 882097007089 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 882097007090 Walker A/P-loop; other site 882097007091 ATP binding site [chemical binding]; other site 882097007092 Q-loop/lid; other site 882097007093 ABC transporter signature motif; other site 882097007094 Walker B; other site 882097007095 D-loop; other site 882097007096 H-loop/switch region; other site 882097007097 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 882097007098 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882097007099 ABC-ATPase subunit interface; other site 882097007100 dimer interface [polypeptide binding]; other site 882097007101 putative PBP binding regions; other site 882097007102 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 882097007103 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 882097007104 intersubunit interface [polypeptide binding]; other site 882097007105 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 882097007106 heme-binding site [chemical binding]; other site 882097007107 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 882097007108 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 882097007109 heme-binding site [chemical binding]; other site 882097007110 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 882097007111 heme-binding site [chemical binding]; other site 882097007112 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 882097007113 heme uptake protein IsdC; Region: IsdC; TIGR03656 882097007114 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 882097007115 heme-binding site [chemical binding]; other site 882097007116 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 882097007117 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 882097007118 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 882097007119 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 882097007120 active site 882097007121 Zn binding site [ion binding]; other site 882097007122 Competence protein CoiA-like family; Region: CoiA; cl11541 882097007123 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 882097007124 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 882097007125 ArsC family; Region: ArsC; pfam03960 882097007126 putative catalytic residues [active] 882097007127 thiol/disulfide switch; other site 882097007128 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 882097007129 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 882097007130 Walker A/P-loop; other site 882097007131 ATP binding site [chemical binding]; other site 882097007132 Q-loop/lid; other site 882097007133 ABC transporter signature motif; other site 882097007134 Walker B; other site 882097007135 D-loop; other site 882097007136 H-loop/switch region; other site 882097007137 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 882097007138 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 882097007139 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 882097007140 Walker A/P-loop; other site 882097007141 ATP binding site [chemical binding]; other site 882097007142 Q-loop/lid; other site 882097007143 ABC transporter signature motif; other site 882097007144 Walker B; other site 882097007145 D-loop; other site 882097007146 H-loop/switch region; other site 882097007147 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 882097007148 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 882097007149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097007150 dimer interface [polypeptide binding]; other site 882097007151 conserved gate region; other site 882097007152 putative PBP binding loops; other site 882097007153 ABC-ATPase subunit interface; other site 882097007154 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 882097007155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097007156 dimer interface [polypeptide binding]; other site 882097007157 conserved gate region; other site 882097007158 putative PBP binding loops; other site 882097007159 ABC-ATPase subunit interface; other site 882097007160 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 882097007161 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 882097007162 peptide binding site [polypeptide binding]; other site 882097007163 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 882097007164 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 882097007165 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 882097007166 active site 882097007167 HIGH motif; other site 882097007168 dimer interface [polypeptide binding]; other site 882097007169 KMSKS motif; other site 882097007170 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 882097007171 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882097007172 MarR family; Region: MarR; pfam01047 882097007173 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 882097007174 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 882097007175 dimer interface [polypeptide binding]; other site 882097007176 active site 882097007177 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 882097007178 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 882097007179 dimer interface [polypeptide binding]; other site 882097007180 active site 882097007181 CoA binding pocket [chemical binding]; other site 882097007182 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882097007183 SH3-like domain; Region: SH3_8; pfam13457 882097007184 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 882097007185 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882097007186 catalytic core [active] 882097007187 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882097007188 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 882097007189 Clp amino terminal domain; Region: Clp_N; pfam02861 882097007190 Clp amino terminal domain; Region: Clp_N; pfam02861 882097007191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097007192 Walker A motif; other site 882097007193 ATP binding site [chemical binding]; other site 882097007194 Walker B motif; other site 882097007195 arginine finger; other site 882097007196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097007197 Walker A motif; other site 882097007198 ATP binding site [chemical binding]; other site 882097007199 Walker B motif; other site 882097007200 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 882097007201 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 882097007202 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 882097007203 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882097007204 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097007205 active site 882097007206 motif I; other site 882097007207 motif II; other site 882097007208 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 882097007209 Predicted acetyltransferase [General function prediction only]; Region: COG3393 882097007210 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 882097007211 ferrochelatase; Provisional; Region: PRK12435 882097007212 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 882097007213 C-terminal domain interface [polypeptide binding]; other site 882097007214 active site 882097007215 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 882097007216 active site 882097007217 N-terminal domain interface [polypeptide binding]; other site 882097007218 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 882097007219 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 882097007220 substrate binding site [chemical binding]; other site 882097007221 active site 882097007222 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 882097007223 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 882097007224 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 882097007225 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882097007226 Walker A/P-loop; other site 882097007227 ATP binding site [chemical binding]; other site 882097007228 Q-loop/lid; other site 882097007229 ABC transporter signature motif; other site 882097007230 Walker B; other site 882097007231 D-loop; other site 882097007232 H-loop/switch region; other site 882097007233 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 882097007234 HIT family signature motif; other site 882097007235 catalytic residue [active] 882097007236 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 882097007237 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 882097007238 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 882097007239 SurA N-terminal domain; Region: SurA_N_3; cl07813 882097007240 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 882097007241 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 882097007242 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 882097007243 generic binding surface II; other site 882097007244 generic binding surface I; other site 882097007245 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882097007246 Zn2+ binding site [ion binding]; other site 882097007247 Mg2+ binding site [ion binding]; other site 882097007248 Uncharacterized conserved protein [Function unknown]; Region: COG4717 882097007249 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 882097007250 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 882097007251 active site 882097007252 metal binding site [ion binding]; metal-binding site 882097007253 DNA binding site [nucleotide binding] 882097007254 hypothetical protein; Provisional; Region: PRK13676 882097007255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 882097007256 fumarate hydratase; Reviewed; Region: fumC; PRK00485 882097007257 Class II fumarases; Region: Fumarase_classII; cd01362 882097007258 active site 882097007259 tetramer interface [polypeptide binding]; other site 882097007260 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 882097007261 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882097007262 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882097007263 Walker A/P-loop; other site 882097007264 ATP binding site [chemical binding]; other site 882097007265 Q-loop/lid; other site 882097007266 ABC transporter signature motif; other site 882097007267 Walker B; other site 882097007268 D-loop; other site 882097007269 H-loop/switch region; other site 882097007270 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 882097007271 Transglycosylase; Region: Transgly; pfam00912 882097007272 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 882097007273 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 882097007274 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 882097007275 Low molecular weight phosphatase family; Region: LMWPc; cl00105 882097007276 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 882097007277 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 882097007278 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 882097007279 Domain of unknown function DUF21; Region: DUF21; pfam01595 882097007280 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 882097007281 Transporter associated domain; Region: CorC_HlyC; smart01091 882097007282 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882097007283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882097007284 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 882097007285 putative dimerization interface [polypeptide binding]; other site 882097007286 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 882097007287 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 882097007288 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 882097007289 active site 882097007290 FMN binding site [chemical binding]; other site 882097007291 substrate binding site [chemical binding]; other site 882097007292 putative catalytic residue [active] 882097007293 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882097007294 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882097007295 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 882097007296 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 882097007297 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 882097007298 shikimate binding site; other site 882097007299 NAD(P) binding site [chemical binding]; other site 882097007300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097007301 putative substrate translocation pore; other site 882097007302 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882097007303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097007304 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882097007305 putative substrate translocation pore; other site 882097007306 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882097007307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097007308 Walker A/P-loop; other site 882097007309 ATP binding site [chemical binding]; other site 882097007310 Q-loop/lid; other site 882097007311 ABC transporter signature motif; other site 882097007312 Walker B; other site 882097007313 D-loop; other site 882097007314 H-loop/switch region; other site 882097007315 Predicted transcriptional regulators [Transcription]; Region: COG1725 882097007316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882097007317 DNA-binding site [nucleotide binding]; DNA binding site 882097007318 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 882097007319 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 882097007320 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 882097007321 DNA binding site [nucleotide binding] 882097007322 active site 882097007323 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 882097007324 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 882097007325 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882097007326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882097007327 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 882097007328 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 882097007329 active site 882097007330 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 882097007331 putative dimer interface [polypeptide binding]; other site 882097007332 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882097007333 ligand binding site [chemical binding]; other site 882097007334 Zn binding site [ion binding]; other site 882097007335 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 882097007336 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 882097007337 active site 882097007338 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882097007339 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882097007340 active site 882097007341 catalytic tetrad [active] 882097007342 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 882097007343 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 882097007344 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 882097007345 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 882097007346 substrate binding pocket [chemical binding]; other site 882097007347 membrane-bound complex binding site; other site 882097007348 hinge residues; other site 882097007349 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 882097007350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097007351 dimer interface [polypeptide binding]; other site 882097007352 conserved gate region; other site 882097007353 putative PBP binding loops; other site 882097007354 ABC-ATPase subunit interface; other site 882097007355 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 882097007356 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 882097007357 Walker A/P-loop; other site 882097007358 ATP binding site [chemical binding]; other site 882097007359 Q-loop/lid; other site 882097007360 ABC transporter signature motif; other site 882097007361 Walker B; other site 882097007362 D-loop; other site 882097007363 H-loop/switch region; other site 882097007364 aspartate aminotransferase; Provisional; Region: PRK06348 882097007365 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882097007366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097007367 homodimer interface [polypeptide binding]; other site 882097007368 catalytic residue [active] 882097007369 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 882097007370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097007371 motif II; other site 882097007372 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 882097007373 intracellular protease, PfpI family; Region: PfpI; TIGR01382 882097007374 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 882097007375 proposed catalytic triad [active] 882097007376 conserved cys residue [active] 882097007377 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882097007378 methionine cluster; other site 882097007379 active site 882097007380 phosphorylation site [posttranslational modification] 882097007381 metal binding site [ion binding]; metal-binding site 882097007382 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 882097007383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097007384 Coenzyme A binding pocket [chemical binding]; other site 882097007385 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 882097007386 esterase; Provisional; Region: PRK10566 882097007387 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 882097007388 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882097007389 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 882097007390 motif II; other site 882097007391 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097007392 Uncharacterized conserved protein [Function unknown]; Region: COG1284 882097007393 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882097007394 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882097007395 hypothetical protein; Provisional; Region: PRK13673 882097007396 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 882097007397 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 882097007398 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 882097007399 Part of AAA domain; Region: AAA_19; pfam13245 882097007400 Family description; Region: UvrD_C_2; pfam13538 882097007401 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 882097007402 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 882097007403 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 882097007404 IDEAL domain; Region: IDEAL; pfam08858 882097007405 ComK protein; Region: ComK; cl11560 882097007406 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 882097007407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097007408 non-specific DNA binding site [nucleotide binding]; other site 882097007409 salt bridge; other site 882097007410 sequence-specific DNA binding site [nucleotide binding]; other site 882097007411 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 882097007412 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097007413 active site 882097007414 phosphorylation site [posttranslational modification] 882097007415 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882097007416 active site 882097007417 P-loop; other site 882097007418 phosphorylation site [posttranslational modification] 882097007419 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882097007420 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 882097007421 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 882097007422 putative substrate binding site [chemical binding]; other site 882097007423 putative ATP binding site [chemical binding]; other site 882097007424 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882097007425 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 882097007426 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882097007427 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 882097007428 trimer interface [polypeptide binding]; other site 882097007429 active site 882097007430 G bulge; other site 882097007431 Uncharacterized conserved protein [Function unknown]; Region: COG1683 882097007432 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 882097007433 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 882097007434 non-specific DNA interactions [nucleotide binding]; other site 882097007435 DNA binding site [nucleotide binding] 882097007436 sequence specific DNA binding site [nucleotide binding]; other site 882097007437 putative cAMP binding site [chemical binding]; other site 882097007438 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 882097007439 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 882097007440 substrate binding site [chemical binding]; other site 882097007441 ATP binding site [chemical binding]; other site 882097007442 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 882097007443 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882097007444 RNA binding surface [nucleotide binding]; other site 882097007445 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 882097007446 active site 882097007447 uracil binding [chemical binding]; other site 882097007448 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 882097007449 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 882097007450 active site 882097007451 non-prolyl cis peptide bond; other site 882097007452 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 882097007453 catalytic residues [active] 882097007454 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 882097007455 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 882097007456 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 882097007457 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 882097007458 Walker A/P-loop; other site 882097007459 ATP binding site [chemical binding]; other site 882097007460 Q-loop/lid; other site 882097007461 ABC transporter signature motif; other site 882097007462 Walker B; other site 882097007463 D-loop; other site 882097007464 H-loop/switch region; other site 882097007465 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 882097007466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097007467 dimer interface [polypeptide binding]; other site 882097007468 conserved gate region; other site 882097007469 putative PBP binding loops; other site 882097007470 ABC-ATPase subunit interface; other site 882097007471 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 882097007472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097007473 dimer interface [polypeptide binding]; other site 882097007474 conserved gate region; other site 882097007475 putative PBP binding loops; other site 882097007476 ABC-ATPase subunit interface; other site 882097007477 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 882097007478 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 882097007479 substrate binding pocket [chemical binding]; other site 882097007480 membrane-bound complex binding site; other site 882097007481 hinge residues; other site 882097007482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097007483 Coenzyme A binding pocket [chemical binding]; other site 882097007484 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 882097007485 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 882097007486 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882097007487 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882097007488 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 882097007489 dimerization interface [polypeptide binding]; other site 882097007490 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 882097007491 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 882097007492 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 882097007493 active site 882097007494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097007495 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882097007496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097007497 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 882097007498 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 882097007499 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 882097007500 active site 882097007501 trimer interface [polypeptide binding]; other site 882097007502 allosteric site; other site 882097007503 active site lid [active] 882097007504 hexamer (dimer of trimers) interface [polypeptide binding]; other site 882097007505 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882097007506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 882097007507 Predicted membrane protein [Function unknown]; Region: COG1511 882097007508 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 882097007509 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 882097007510 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 882097007511 Predicted transcriptional regulator [Transcription]; Region: COG1959 882097007512 Transcriptional regulator; Region: Rrf2; pfam02082 882097007513 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 882097007514 L-tyrosine decarboxylase; Provisional; Region: PRK13520 882097007515 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 882097007516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097007517 catalytic residue [active] 882097007518 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 882097007519 Mga helix-turn-helix domain; Region: Mga; pfam05043 882097007520 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 882097007521 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 882097007522 ADP-ribose binding site [chemical binding]; other site 882097007523 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882097007524 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 882097007525 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882097007526 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 882097007527 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 882097007528 active site 882097007529 dimer interface [polypeptide binding]; other site 882097007530 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 882097007531 dimer interface [polypeptide binding]; other site 882097007532 active site 882097007533 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 882097007534 nudix motif; other site 882097007535 general stress protein 13; Validated; Region: PRK08059 882097007536 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 882097007537 RNA binding site [nucleotide binding]; other site 882097007538 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 882097007539 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882097007540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097007541 homodimer interface [polypeptide binding]; other site 882097007542 catalytic residue [active] 882097007543 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 882097007544 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882097007545 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882097007546 Walker A/P-loop; other site 882097007547 ATP binding site [chemical binding]; other site 882097007548 Q-loop/lid; other site 882097007549 ABC transporter signature motif; other site 882097007550 Walker B; other site 882097007551 D-loop; other site 882097007552 H-loop/switch region; other site 882097007553 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882097007554 active site 882097007555 P-loop; other site 882097007556 phosphorylation site [posttranslational modification] 882097007557 aspartate kinase; Reviewed; Region: PRK09034 882097007558 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 882097007559 putative catalytic residues [active] 882097007560 putative nucleotide binding site [chemical binding]; other site 882097007561 putative aspartate binding site [chemical binding]; other site 882097007562 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 882097007563 allosteric regulatory residue; other site 882097007564 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 882097007565 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 882097007566 active site 882097007567 drug efflux system protein MdtG; Provisional; Region: PRK09874 882097007568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097007569 putative substrate translocation pore; other site 882097007570 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 882097007571 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 882097007572 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 882097007573 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 882097007574 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 882097007575 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 882097007576 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 882097007577 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 882097007578 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 882097007579 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 882097007580 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 882097007581 CoenzymeA binding site [chemical binding]; other site 882097007582 subunit interaction site [polypeptide binding]; other site 882097007583 PHB binding site; other site 882097007584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 882097007585 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 882097007586 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 882097007587 Cl- selectivity filter; other site 882097007588 Cl- binding residues [ion binding]; other site 882097007589 pore gating glutamate residue; other site 882097007590 dimer interface [polypeptide binding]; other site 882097007591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 882097007592 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 882097007593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882097007594 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 882097007595 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882097007596 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882097007597 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 882097007598 NADH(P)-binding; Region: NAD_binding_10; pfam13460 882097007599 NAD(P) binding site [chemical binding]; other site 882097007600 putative active site [active] 882097007601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844 882097007602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 882097007603 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097007604 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097007605 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097007606 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097007607 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097007608 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097007609 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097007610 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097007611 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097007612 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 882097007613 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 882097007614 tetramer interfaces [polypeptide binding]; other site 882097007615 binuclear metal-binding site [ion binding]; other site 882097007616 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 882097007617 Domain of unknown function DUF21; Region: DUF21; pfam01595 882097007618 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 882097007619 Transporter associated domain; Region: CorC_HlyC; smart01091 882097007620 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882097007621 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097007622 Coenzyme A binding pocket [chemical binding]; other site 882097007623 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 882097007624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097007625 active site 882097007626 motif I; other site 882097007627 motif II; other site 882097007628 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097007629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 882097007630 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 882097007631 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 882097007632 active site 882097007633 metal binding site [ion binding]; metal-binding site 882097007634 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 882097007635 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 882097007636 Predicted membrane protein [Function unknown]; Region: COG4272 882097007637 Uncharacterized conserved protein [Function unknown]; Region: COG1801 882097007638 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 882097007639 FeS assembly protein SufB; Region: sufB; TIGR01980 882097007640 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 882097007641 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 882097007642 trimerization site [polypeptide binding]; other site 882097007643 active site 882097007644 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 882097007645 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 882097007646 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882097007647 catalytic residue [active] 882097007648 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 882097007649 FeS assembly protein SufD; Region: sufD; TIGR01981 882097007650 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 882097007651 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 882097007652 Walker A/P-loop; other site 882097007653 ATP binding site [chemical binding]; other site 882097007654 Q-loop/lid; other site 882097007655 ABC transporter signature motif; other site 882097007656 Walker B; other site 882097007657 D-loop; other site 882097007658 H-loop/switch region; other site 882097007659 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 882097007660 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 882097007661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097007662 ABC-ATPase subunit interface; other site 882097007663 putative PBP binding loops; other site 882097007664 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 882097007665 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 882097007666 Walker A/P-loop; other site 882097007667 ATP binding site [chemical binding]; other site 882097007668 Q-loop/lid; other site 882097007669 ABC transporter signature motif; other site 882097007670 Walker B; other site 882097007671 D-loop; other site 882097007672 H-loop/switch region; other site 882097007673 NIL domain; Region: NIL; pfam09383 882097007674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882097007675 dimer interface [polypeptide binding]; other site 882097007676 phosphorylation site [posttranslational modification] 882097007677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097007678 ATP binding site [chemical binding]; other site 882097007679 Mg2+ binding site [ion binding]; other site 882097007680 G-X-G motif; other site 882097007681 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882097007682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097007683 active site 882097007684 phosphorylation site [posttranslational modification] 882097007685 intermolecular recognition site; other site 882097007686 dimerization interface [polypeptide binding]; other site 882097007687 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882097007688 DNA binding site [nucleotide binding] 882097007689 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 882097007690 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 882097007691 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882097007692 catalytic residues [active] 882097007693 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 882097007694 lipoyl attachment site [posttranslational modification]; other site 882097007695 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 882097007696 ArsC family; Region: ArsC; pfam03960 882097007697 putative ArsC-like catalytic residues; other site 882097007698 putative TRX-like catalytic residues [active] 882097007699 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 882097007700 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 882097007701 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 882097007702 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 882097007703 Walker A/P-loop; other site 882097007704 ATP binding site [chemical binding]; other site 882097007705 Q-loop/lid; other site 882097007706 ABC transporter signature motif; other site 882097007707 Walker B; other site 882097007708 D-loop; other site 882097007709 H-loop/switch region; other site 882097007710 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 882097007711 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882097007712 ABC-ATPase subunit interface; other site 882097007713 dimer interface [polypeptide binding]; other site 882097007714 putative PBP binding regions; other site 882097007715 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 882097007716 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 882097007717 intersubunit interface [polypeptide binding]; other site 882097007718 Predicted esterase [General function prediction only]; Region: COG0627 882097007719 S-formylglutathione hydrolase; Region: PLN02442 882097007720 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 882097007721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097007722 catalytic residue [active] 882097007723 SdpI/YhfL protein family; Region: SdpI; pfam13630 882097007724 CAT RNA binding domain; Region: CAT_RBD; smart01061 882097007725 transcriptional antiterminator BglG; Provisional; Region: PRK09772 882097007726 PRD domain; Region: PRD; pfam00874 882097007727 PRD domain; Region: PRD; pfam00874 882097007728 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 882097007729 Uncharacterized conserved protein [Function unknown]; Region: COG4283 882097007730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 882097007731 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 882097007732 Predicted transcriptional regulator [Transcription]; Region: COG2378 882097007733 HTH domain; Region: HTH_11; pfam08279 882097007734 WYL domain; Region: WYL; pfam13280 882097007735 Uncharacterized conserved protein [Function unknown]; Region: COG1434 882097007736 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 882097007737 putative active site [active] 882097007738 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882097007739 Leucine rich repeat; Region: LRR_8; pfam13855 882097007740 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 882097007741 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 882097007742 active site 882097007743 catalytic site [active] 882097007744 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 882097007745 putative metal binding site [ion binding]; other site 882097007746 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 882097007747 putative metal binding site [ion binding]; other site 882097007748 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882097007749 Leucine rich repeat; Region: LRR_8; pfam13855 882097007750 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 882097007751 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 882097007752 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 882097007753 active site 882097007754 catalytic site [active] 882097007755 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 882097007756 putative metal binding site [ion binding]; other site 882097007757 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 882097007758 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097007759 non-specific DNA binding site [nucleotide binding]; other site 882097007760 salt bridge; other site 882097007761 sequence-specific DNA binding site [nucleotide binding]; other site 882097007762 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 882097007763 Tetratricopeptide repeat; Region: TPR_12; pfam13424 882097007764 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 882097007765 SmpB-tmRNA interface; other site 882097007766 ribonuclease R; Region: RNase_R; TIGR02063 882097007767 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 882097007768 RNB domain; Region: RNB; pfam00773 882097007769 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 882097007770 RNA binding site [nucleotide binding]; other site 882097007771 Esterase/lipase [General function prediction only]; Region: COG1647 882097007772 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882097007773 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 882097007774 Preprotein translocase SecG subunit; Region: SecG; cl09123 882097007775 Esterase/lipase [General function prediction only]; Region: COG1647 882097007776 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882097007777 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 882097007778 PGAP1-like protein; Region: PGAP1; pfam07819 882097007779 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 882097007780 enolase; Provisional; Region: eno; PRK00077 882097007781 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 882097007782 dimer interface [polypeptide binding]; other site 882097007783 metal binding site [ion binding]; metal-binding site 882097007784 substrate binding pocket [chemical binding]; other site 882097007785 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 882097007786 phosphoglyceromutase; Provisional; Region: PRK05434 882097007787 triosephosphate isomerase; Provisional; Region: PRK14567 882097007788 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 882097007789 substrate binding site [chemical binding]; other site 882097007790 dimer interface [polypeptide binding]; other site 882097007791 catalytic triad [active] 882097007792 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 882097007793 Phosphoglycerate kinase; Region: PGK; pfam00162 882097007794 substrate binding site [chemical binding]; other site 882097007795 hinge regions; other site 882097007796 ADP binding site [chemical binding]; other site 882097007797 catalytic site [active] 882097007798 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 882097007799 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 882097007800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 882097007801 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 882097007802 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 882097007803 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 882097007804 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 882097007805 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 882097007806 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882097007807 DNA binding site [nucleotide binding] 882097007808 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 882097007809 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 882097007810 active site 882097007811 dimer interface [polypeptide binding]; other site 882097007812 MMPL family; Region: MMPL; pfam03176 882097007813 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 882097007814 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882097007815 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882097007816 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 882097007817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 882097007818 Chitin binding domain; Region: Chitin_bind_3; pfam03067 882097007819 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 882097007820 Interdomain contacts; other site 882097007821 Cytokine receptor motif; other site 882097007822 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 882097007823 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 882097007824 Interdomain contacts; other site 882097007825 Cytokine receptor motif; other site 882097007826 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 882097007827 aromatic chitin/cellulose binding site residues [chemical binding]; other site 882097007828 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 882097007829 aromatic chitin/cellulose binding site residues [chemical binding]; other site 882097007830 Clp protease; Region: CLP_protease; pfam00574 882097007831 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 882097007832 oligomer interface [polypeptide binding]; other site 882097007833 active site residues [active] 882097007834 amino acid transporter; Region: 2A0306; TIGR00909 882097007835 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 882097007836 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882097007837 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882097007838 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097007839 Substrate binding site [chemical binding]; other site 882097007840 Leucine rich repeat; Region: LRR_8; pfam13855 882097007841 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 882097007842 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 882097007843 active site 882097007844 FMN binding site [chemical binding]; other site 882097007845 substrate binding site [chemical binding]; other site 882097007846 homotetramer interface [polypeptide binding]; other site 882097007847 catalytic residue [active] 882097007848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 882097007849 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 882097007850 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 882097007851 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 882097007852 phosphate binding site [ion binding]; other site 882097007853 putative substrate binding pocket [chemical binding]; other site 882097007854 dimer interface [polypeptide binding]; other site 882097007855 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 882097007856 AAA domain; Region: AAA_18; pfam13238 882097007857 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 882097007858 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 882097007859 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 882097007860 active site 882097007861 substrate binding site [chemical binding]; other site 882097007862 metal binding site [ion binding]; metal-binding site 882097007863 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 882097007864 active site 882097007865 catalytic residues [active] 882097007866 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 882097007867 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 882097007868 NAD binding site [chemical binding]; other site 882097007869 homodimer interface [polypeptide binding]; other site 882097007870 active site 882097007871 substrate binding site [chemical binding]; other site 882097007872 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 882097007873 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882097007874 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882097007875 TPR repeat; Region: TPR_11; pfam13414 882097007876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882097007877 binding surface 882097007878 TPR motif; other site 882097007879 Tetratricopeptide repeat; Region: TPR_12; pfam13424 882097007880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882097007881 binding surface 882097007882 TPR motif; other site 882097007883 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 882097007884 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 882097007885 trimer interface [polypeptide binding]; other site 882097007886 active site 882097007887 substrate binding site [chemical binding]; other site 882097007888 CoA binding site [chemical binding]; other site 882097007889 pyrophosphatase PpaX; Provisional; Region: PRK13288 882097007890 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 882097007891 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097007892 motif II; other site 882097007893 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 882097007894 HPr kinase/phosphorylase; Provisional; Region: PRK05428 882097007895 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 882097007896 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 882097007897 Hpr binding site; other site 882097007898 active site 882097007899 homohexamer subunit interaction site [polypeptide binding]; other site 882097007900 Predicted membrane protein [Function unknown]; Region: COG1950 882097007901 PspC domain; Region: PspC; pfam04024 882097007902 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 882097007903 Uncharacterized conserved protein [Function unknown]; Region: COG3595 882097007904 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 882097007905 Uncharacterized conserved protein [Function unknown]; Region: COG3595 882097007906 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 882097007907 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 882097007908 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 882097007909 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 882097007910 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 882097007911 excinuclease ABC subunit B; Provisional; Region: PRK05298 882097007912 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882097007913 ATP binding site [chemical binding]; other site 882097007914 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882097007915 nucleotide binding region [chemical binding]; other site 882097007916 ATP-binding site [chemical binding]; other site 882097007917 Ultra-violet resistance protein B; Region: UvrB; pfam12344 882097007918 UvrB/uvrC motif; Region: UVR; pfam02151 882097007919 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 882097007920 HD containing hydrolase-like enzyme; Region: HD_2; pfam12917 882097007921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882097007922 dimerization interface [polypeptide binding]; other site 882097007923 putative DNA binding site [nucleotide binding]; other site 882097007924 putative Zn2+ binding site [ion binding]; other site 882097007925 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 882097007926 PhoU domain; Region: PhoU; pfam01895 882097007927 PhoU domain; Region: PhoU; pfam01895 882097007928 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 882097007929 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 882097007930 Walker A/P-loop; other site 882097007931 ATP binding site [chemical binding]; other site 882097007932 Q-loop/lid; other site 882097007933 ABC transporter signature motif; other site 882097007934 Walker B; other site 882097007935 D-loop; other site 882097007936 H-loop/switch region; other site 882097007937 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 882097007938 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 882097007939 Walker A/P-loop; other site 882097007940 ATP binding site [chemical binding]; other site 882097007941 Q-loop/lid; other site 882097007942 ABC transporter signature motif; other site 882097007943 Walker B; other site 882097007944 D-loop; other site 882097007945 H-loop/switch region; other site 882097007946 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 882097007947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097007948 dimer interface [polypeptide binding]; other site 882097007949 conserved gate region; other site 882097007950 putative PBP binding loops; other site 882097007951 ABC-ATPase subunit interface; other site 882097007952 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 882097007953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097007954 dimer interface [polypeptide binding]; other site 882097007955 conserved gate region; other site 882097007956 putative PBP binding loops; other site 882097007957 ABC-ATPase subunit interface; other site 882097007958 PBP superfamily domain; Region: PBP_like_2; cl17296 882097007959 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 882097007960 HAMP domain; Region: HAMP; pfam00672 882097007961 dimerization interface [polypeptide binding]; other site 882097007962 PAS domain; Region: PAS; smart00091 882097007963 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 882097007964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882097007965 dimer interface [polypeptide binding]; other site 882097007966 phosphorylation site [posttranslational modification] 882097007967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097007968 ATP binding site [chemical binding]; other site 882097007969 Mg2+ binding site [ion binding]; other site 882097007970 G-X-G motif; other site 882097007971 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882097007972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097007973 active site 882097007974 phosphorylation site [posttranslational modification] 882097007975 intermolecular recognition site; other site 882097007976 dimerization interface [polypeptide binding]; other site 882097007977 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882097007978 DNA binding site [nucleotide binding] 882097007979 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 882097007980 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 882097007981 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 882097007982 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 882097007983 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 882097007984 putative active site [active] 882097007985 catalytic site [active] 882097007986 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 882097007987 putative active site [active] 882097007988 catalytic site [active] 882097007989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 882097007990 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 882097007991 Peptidase family M23; Region: Peptidase_M23; pfam01551 882097007992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 882097007993 NlpC/P60 family; Region: NLPC_P60; pfam00877 882097007994 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 882097007995 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 882097007996 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 882097007997 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097007998 Walker A/P-loop; other site 882097007999 ATP binding site [chemical binding]; other site 882097008000 Q-loop/lid; other site 882097008001 ABC transporter signature motif; other site 882097008002 Walker B; other site 882097008003 D-loop; other site 882097008004 H-loop/switch region; other site 882097008005 Uncharacterized conserved protein [Function unknown]; Region: COG1284 882097008006 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882097008007 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882097008008 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882097008009 peptide chain release factor 2; Validated; Region: prfB; PRK00578 882097008010 This domain is found in peptide chain release factors; Region: PCRF; smart00937 882097008011 RF-1 domain; Region: RF-1; pfam00472 882097008012 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 882097008013 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 882097008014 nucleotide binding region [chemical binding]; other site 882097008015 helicase superfamily c-terminal domain; Region: HELICc; smart00490 882097008016 ATP-binding site [chemical binding]; other site 882097008017 SEC-C motif; Region: SEC-C; pfam02810 882097008018 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 882097008019 30S subunit binding site; other site 882097008020 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 882097008021 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882097008022 active site 882097008023 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 882097008024 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882097008025 ATP binding site [chemical binding]; other site 882097008026 putative Mg++ binding site [ion binding]; other site 882097008027 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 882097008028 nucleotide binding region [chemical binding]; other site 882097008029 ATP-binding site [chemical binding]; other site 882097008030 EDD domain protein, DegV family; Region: DegV; TIGR00762 882097008031 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 882097008032 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 882097008033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097008034 active site 882097008035 phosphorylation site [posttranslational modification] 882097008036 intermolecular recognition site; other site 882097008037 dimerization interface [polypeptide binding]; other site 882097008038 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 882097008039 DNA binding residues [nucleotide binding] 882097008040 dimerization interface [polypeptide binding]; other site 882097008041 Uncharacterized conserved protein [Function unknown]; Region: COG1739 882097008042 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 882097008043 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 882097008044 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 882097008045 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 882097008046 Transcriptional regulator [Transcription]; Region: LytR; COG1316 882097008047 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 882097008048 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 882097008049 Mg++ binding site [ion binding]; other site 882097008050 putative catalytic motif [active] 882097008051 substrate binding site [chemical binding]; other site 882097008052 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 882097008053 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 882097008054 active site 882097008055 octamer interface [polypeptide binding]; other site 882097008056 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 882097008057 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 882097008058 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882097008059 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 882097008060 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882097008061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 882097008062 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 882097008063 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 882097008064 dimer interface [polypeptide binding]; other site 882097008065 ssDNA binding site [nucleotide binding]; other site 882097008066 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882097008067 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 882097008068 rod shape-determining protein Mbl; Provisional; Region: PRK13928 882097008069 MreB and similar proteins; Region: MreB_like; cd10225 882097008070 nucleotide binding site [chemical binding]; other site 882097008071 Mg binding site [ion binding]; other site 882097008072 putative protofilament interaction site [polypeptide binding]; other site 882097008073 RodZ interaction site [polypeptide binding]; other site 882097008074 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 882097008075 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 882097008076 hinge; other site 882097008077 active site 882097008078 Predicted membrane protein [Function unknown]; Region: COG4836 882097008079 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 882097008080 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 882097008081 gamma subunit interface [polypeptide binding]; other site 882097008082 epsilon subunit interface [polypeptide binding]; other site 882097008083 LBP interface [polypeptide binding]; other site 882097008084 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 882097008085 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 882097008086 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 882097008087 alpha subunit interaction interface [polypeptide binding]; other site 882097008088 Walker A motif; other site 882097008089 ATP binding site [chemical binding]; other site 882097008090 Walker B motif; other site 882097008091 inhibitor binding site; inhibition site 882097008092 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 882097008093 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 882097008094 core domain interface [polypeptide binding]; other site 882097008095 delta subunit interface [polypeptide binding]; other site 882097008096 epsilon subunit interface [polypeptide binding]; other site 882097008097 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 882097008098 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 882097008099 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 882097008100 beta subunit interaction interface [polypeptide binding]; other site 882097008101 Walker A motif; other site 882097008102 ATP binding site [chemical binding]; other site 882097008103 Walker B motif; other site 882097008104 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 882097008105 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 882097008106 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 882097008107 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 882097008108 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 882097008109 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 882097008110 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 882097008111 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 882097008112 ATP synthase I chain; Region: ATP_synt_I; pfam03899 882097008113 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 882097008114 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 882097008115 active site 882097008116 homodimer interface [polypeptide binding]; other site 882097008117 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882097008118 active site 882097008119 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 882097008120 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 882097008121 dimer interface [polypeptide binding]; other site 882097008122 active site 882097008123 glycine-pyridoxal phosphate binding site [chemical binding]; other site 882097008124 folate binding site [chemical binding]; other site 882097008125 Low molecular weight phosphatase family; Region: LMWPc; cd00115 882097008126 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 882097008127 active site 882097008128 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 882097008129 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 882097008130 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 882097008131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097008132 S-adenosylmethionine binding site [chemical binding]; other site 882097008133 peptide chain release factor 1; Validated; Region: prfA; PRK00591 882097008134 This domain is found in peptide chain release factors; Region: PCRF; smart00937 882097008135 RF-1 domain; Region: RF-1; pfam00472 882097008136 thymidine kinase; Provisional; Region: PRK04296 882097008137 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 882097008138 ATP binding site [chemical binding]; other site 882097008139 Walker A motif; other site 882097008140 Walker B motif; other site 882097008141 homoserine kinase; Provisional; Region: PRK01212 882097008142 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 882097008143 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 882097008144 threonine synthase; Reviewed; Region: PRK06721 882097008145 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 882097008146 homodimer interface [polypeptide binding]; other site 882097008147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097008148 catalytic residue [active] 882097008149 homoserine dehydrogenase; Provisional; Region: PRK06349 882097008150 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 882097008151 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 882097008152 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 882097008153 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 882097008154 Predicted membrane protein [Function unknown]; Region: COG2246 882097008155 GtrA-like protein; Region: GtrA; pfam04138 882097008156 transcription termination factor Rho; Provisional; Region: rho; PRK09376 882097008157 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 882097008158 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 882097008159 RNA binding site [nucleotide binding]; other site 882097008160 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 882097008161 multimer interface [polypeptide binding]; other site 882097008162 Walker A motif; other site 882097008163 ATP binding site [chemical binding]; other site 882097008164 Walker B motif; other site 882097008165 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 882097008166 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 882097008167 hinge; other site 882097008168 active site 882097008169 Predicted integral membrane protein [Function unknown]; Region: COG0392 882097008170 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 882097008171 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 882097008172 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 882097008173 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 882097008174 putative ADP-binding pocket [chemical binding]; other site 882097008175 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 882097008176 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 882097008177 intersubunit interface [polypeptide binding]; other site 882097008178 active site 882097008179 zinc binding site [ion binding]; other site 882097008180 Na+ binding site [ion binding]; other site 882097008181 putative lipid kinase; Reviewed; Region: PRK13055 882097008182 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 882097008183 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 882097008184 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 882097008185 amidase catalytic site [active] 882097008186 Zn binding residues [ion binding]; other site 882097008187 substrate binding site [chemical binding]; other site 882097008188 SH3-like domain; Region: SH3_8; pfam13457 882097008189 SH3-like domain; Region: SH3_8; pfam13457 882097008190 SH3-like domain; Region: SH3_8; pfam13457 882097008191 SH3-like domain; Region: SH3_8; pfam13457 882097008192 CTP synthetase; Validated; Region: pyrG; PRK05380 882097008193 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 882097008194 Catalytic site [active] 882097008195 active site 882097008196 UTP binding site [chemical binding]; other site 882097008197 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 882097008198 active site 882097008199 putative oxyanion hole; other site 882097008200 catalytic triad [active] 882097008201 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 882097008202 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 882097008203 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 882097008204 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 882097008205 active site 882097008206 HIGH motif; other site 882097008207 KMSK motif region; other site 882097008208 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 882097008209 tRNA binding surface [nucleotide binding]; other site 882097008210 anticodon binding site; other site 882097008211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 882097008212 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 882097008213 Peptidase family M50; Region: Peptidase_M50; pfam02163 882097008214 active site 882097008215 putative substrate binding region [chemical binding]; other site 882097008216 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 882097008217 active site 1 [active] 882097008218 dimer interface [polypeptide binding]; other site 882097008219 hexamer interface [polypeptide binding]; other site 882097008220 active site 2 [active] 882097008221 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 882097008222 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882097008223 Zn2+ binding site [ion binding]; other site 882097008224 Mg2+ binding site [ion binding]; other site 882097008225 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 882097008226 conserved hypothetical protein TIGR01655; Region: yxeA_fam 882097008227 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 882097008228 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 882097008229 peptide binding site [polypeptide binding]; other site 882097008230 Predicted integral membrane protein [Function unknown]; Region: COG5658 882097008231 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 882097008232 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 882097008233 catalytic triad [active] 882097008234 metal binding site [ion binding]; metal-binding site 882097008235 conserved cis-peptide bond; other site 882097008236 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 882097008237 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 882097008238 folate binding site [chemical binding]; other site 882097008239 NADP+ binding site [chemical binding]; other site 882097008240 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 882097008241 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 882097008242 putative NAD(P) binding site [chemical binding]; other site 882097008243 dimer interface [polypeptide binding]; other site 882097008244 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 882097008245 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 882097008246 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 882097008247 Collagen binding domain; Region: Collagen_bind; pfam05737 882097008248 Collagen binding domain; Region: Collagen_bind; pfam05737 882097008249 Collagen binding domain; Region: Collagen_bind; pfam05737 882097008250 Cna protein B-type domain; Region: Cna_B; pfam05738 882097008251 Cna protein B-type domain; Region: Cna_B; pfam05738 882097008252 Cna protein B-type domain; Region: Cna_B; pfam05738 882097008253 Cna protein B-type domain; Region: Cna_B; pfam05738 882097008254 Cna protein B-type domain; Region: Cna_B; pfam05738 882097008255 Cna protein B-type domain; Region: Cna_B; pfam05738 882097008256 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882097008257 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097008258 active site 882097008259 motif I; other site 882097008260 motif II; other site 882097008261 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 882097008262 Uncharacterized conserved protein [Function unknown]; Region: COG1359 882097008263 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882097008264 LRR adjacent; Region: LRR_adjacent; pfam08191 882097008265 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097008266 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097008267 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882097008268 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882097008269 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882097008270 Walker A/P-loop; other site 882097008271 ATP binding site [chemical binding]; other site 882097008272 Q-loop/lid; other site 882097008273 ABC transporter signature motif; other site 882097008274 Walker B; other site 882097008275 D-loop; other site 882097008276 H-loop/switch region; other site 882097008277 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882097008278 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882097008279 FtsX-like permease family; Region: FtsX; pfam02687 882097008280 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882097008281 dimerization interface [polypeptide binding]; other site 882097008282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882097008283 dimer interface [polypeptide binding]; other site 882097008284 phosphorylation site [posttranslational modification] 882097008285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097008286 ATP binding site [chemical binding]; other site 882097008287 Mg2+ binding site [ion binding]; other site 882097008288 G-X-G motif; other site 882097008289 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882097008290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097008291 active site 882097008292 phosphorylation site [posttranslational modification] 882097008293 intermolecular recognition site; other site 882097008294 dimerization interface [polypeptide binding]; other site 882097008295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882097008296 DNA binding site [nucleotide binding] 882097008297 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 882097008298 Uncharacterized conserved protein [Function unknown]; Region: COG2427 882097008299 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 882097008300 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 882097008301 catalytic loop [active] 882097008302 iron binding site [ion binding]; other site 882097008303 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 882097008304 4Fe-4S binding domain; Region: Fer4; pfam00037 882097008305 4Fe-4S binding domain; Region: Fer4; pfam00037 882097008306 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 882097008307 [4Fe-4S] binding site [ion binding]; other site 882097008308 molybdopterin cofactor binding site; other site 882097008309 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 882097008310 molybdopterin cofactor binding site; other site 882097008311 Uncharacterized conserved protein [Function unknown]; Region: COG1912 882097008312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097008313 putative substrate translocation pore; other site 882097008314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097008315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882097008316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882097008317 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 882097008318 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 882097008319 Walker A motif; other site 882097008320 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882097008321 SH3-like domain; Region: SH3_8; pfam13457 882097008322 SH3-like domain; Region: SH3_8; pfam13457 882097008323 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882097008324 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882097008325 active site 882097008326 catalytic tetrad [active] 882097008327 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882097008328 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882097008329 DNA binding residues [nucleotide binding] 882097008330 putative dimer interface [polypeptide binding]; other site 882097008331 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 882097008332 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 882097008333 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 882097008334 23S rRNA interface [nucleotide binding]; other site 882097008335 L3 interface [polypeptide binding]; other site 882097008336 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 882097008337 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 882097008338 dimerization interface 3.5A [polypeptide binding]; other site 882097008339 active site 882097008340 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 882097008341 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 882097008342 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 882097008343 Walker A/P-loop; other site 882097008344 ATP binding site [chemical binding]; other site 882097008345 Q-loop/lid; other site 882097008346 ABC transporter signature motif; other site 882097008347 Walker B; other site 882097008348 D-loop; other site 882097008349 H-loop/switch region; other site 882097008350 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 882097008351 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 882097008352 Walker A/P-loop; other site 882097008353 ATP binding site [chemical binding]; other site 882097008354 Q-loop/lid; other site 882097008355 ABC transporter signature motif; other site 882097008356 Walker B; other site 882097008357 D-loop; other site 882097008358 H-loop/switch region; other site 882097008359 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 882097008360 MgtC family; Region: MgtC; pfam02308 882097008361 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 882097008362 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 882097008363 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 882097008364 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 882097008365 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 882097008366 alphaNTD - beta interaction site [polypeptide binding]; other site 882097008367 alphaNTD homodimer interface [polypeptide binding]; other site 882097008368 alphaNTD - beta' interaction site [polypeptide binding]; other site 882097008369 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 882097008370 30S ribosomal protein S11; Validated; Region: PRK05309 882097008371 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 882097008372 30S ribosomal protein S13; Region: bact_S13; TIGR03631 882097008373 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 882097008374 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 882097008375 rRNA binding site [nucleotide binding]; other site 882097008376 predicted 30S ribosome binding site; other site 882097008377 adenylate kinase; Reviewed; Region: adk; PRK00279 882097008378 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 882097008379 AMP-binding site [chemical binding]; other site 882097008380 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 882097008381 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 882097008382 SecY translocase; Region: SecY; pfam00344 882097008383 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 882097008384 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 882097008385 23S rRNA binding site [nucleotide binding]; other site 882097008386 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 882097008387 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 882097008388 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 882097008389 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 882097008390 5S rRNA interface [nucleotide binding]; other site 882097008391 L27 interface [polypeptide binding]; other site 882097008392 23S rRNA interface [nucleotide binding]; other site 882097008393 L5 interface [polypeptide binding]; other site 882097008394 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 882097008395 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 882097008396 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 882097008397 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 882097008398 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 882097008399 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 882097008400 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 882097008401 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 882097008402 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 882097008403 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 882097008404 RNA binding site [nucleotide binding]; other site 882097008405 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 882097008406 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 882097008407 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 882097008408 23S rRNA interface [nucleotide binding]; other site 882097008409 putative translocon interaction site; other site 882097008410 signal recognition particle (SRP54) interaction site; other site 882097008411 L23 interface [polypeptide binding]; other site 882097008412 trigger factor interaction site; other site 882097008413 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 882097008414 23S rRNA interface [nucleotide binding]; other site 882097008415 5S rRNA interface [nucleotide binding]; other site 882097008416 putative antibiotic binding site [chemical binding]; other site 882097008417 L25 interface [polypeptide binding]; other site 882097008418 L27 interface [polypeptide binding]; other site 882097008419 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 882097008420 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 882097008421 G-X-X-G motif; other site 882097008422 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 882097008423 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 882097008424 putative translocon binding site; other site 882097008425 protein-rRNA interface [nucleotide binding]; other site 882097008426 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 882097008427 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 882097008428 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 882097008429 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 882097008430 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 882097008431 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 882097008432 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 882097008433 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 882097008434 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 882097008435 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 882097008436 UbiA prenyltransferase family; Region: UbiA; pfam01040 882097008437 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 882097008438 ApbE family; Region: ApbE; pfam02424 882097008439 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 882097008440 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 882097008441 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 882097008442 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 882097008443 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882097008444 Predicted membrane protein [Function unknown]; Region: COG2259 882097008445 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 882097008446 trimer interface [polypeptide binding]; other site 882097008447 Predicted membrane protein [Function unknown]; Region: COG4769 882097008448 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 882097008449 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 882097008450 substrate binding pocket [chemical binding]; other site 882097008451 chain length determination region; other site 882097008452 substrate-Mg2+ binding site; other site 882097008453 catalytic residues [active] 882097008454 aspartate-rich region 1; other site 882097008455 active site lid residues [active] 882097008456 aspartate-rich region 2; other site 882097008457 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 882097008458 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 882097008459 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 882097008460 active site 882097008461 metal binding site [ion binding]; metal-binding site 882097008462 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 882097008463 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 882097008464 hypothetical protein; Provisional; Region: PRK02947 882097008465 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882097008466 putative active site [active] 882097008467 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 882097008468 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 882097008469 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 882097008470 active site 882097008471 substrate binding pocket [chemical binding]; other site 882097008472 homodimer interaction site [polypeptide binding]; other site 882097008473 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 882097008474 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 882097008475 active site 882097008476 P-loop; other site 882097008477 phosphorylation site [posttranslational modification] 882097008478 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097008479 active site 882097008480 phosphorylation site [posttranslational modification] 882097008481 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882097008482 Mga helix-turn-helix domain; Region: Mga; pfam05043 882097008483 PRD domain; Region: PRD; pfam00874 882097008484 PRD domain; Region: PRD; pfam00874 882097008485 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882097008486 active site 882097008487 P-loop; other site 882097008488 phosphorylation site [posttranslational modification] 882097008489 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097008490 active site 882097008491 phosphorylation site [posttranslational modification] 882097008492 elongation factor Tu; Reviewed; Region: PRK00049 882097008493 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 882097008494 G1 box; other site 882097008495 GEF interaction site [polypeptide binding]; other site 882097008496 GTP/Mg2+ binding site [chemical binding]; other site 882097008497 Switch I region; other site 882097008498 G2 box; other site 882097008499 G3 box; other site 882097008500 Switch II region; other site 882097008501 G4 box; other site 882097008502 G5 box; other site 882097008503 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 882097008504 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 882097008505 Antibiotic Binding Site [chemical binding]; other site 882097008506 elongation factor G; Reviewed; Region: PRK00007 882097008507 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 882097008508 G1 box; other site 882097008509 putative GEF interaction site [polypeptide binding]; other site 882097008510 GTP/Mg2+ binding site [chemical binding]; other site 882097008511 Switch I region; other site 882097008512 G2 box; other site 882097008513 G3 box; other site 882097008514 Switch II region; other site 882097008515 G4 box; other site 882097008516 G5 box; other site 882097008517 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 882097008518 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 882097008519 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 882097008520 30S ribosomal protein S7; Validated; Region: PRK05302 882097008521 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 882097008522 S17 interaction site [polypeptide binding]; other site 882097008523 S8 interaction site; other site 882097008524 16S rRNA interaction site [nucleotide binding]; other site 882097008525 streptomycin interaction site [chemical binding]; other site 882097008526 23S rRNA interaction site [nucleotide binding]; other site 882097008527 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 882097008528 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 882097008529 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882097008530 Zn2+ binding site [ion binding]; other site 882097008531 Mg2+ binding site [ion binding]; other site 882097008532 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 882097008533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097008534 Coenzyme A binding pocket [chemical binding]; other site 882097008535 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 882097008536 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 882097008537 substrate binding site [chemical binding]; other site 882097008538 hexamer interface [polypeptide binding]; other site 882097008539 metal binding site [ion binding]; metal-binding site 882097008540 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 882097008541 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 882097008542 TPP-binding site [chemical binding]; other site 882097008543 dimer interface [polypeptide binding]; other site 882097008544 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 882097008545 PYR/PP interface [polypeptide binding]; other site 882097008546 dimer interface [polypeptide binding]; other site 882097008547 TPP binding site [chemical binding]; other site 882097008548 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 882097008549 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 882097008550 substrate binding site [chemical binding]; other site 882097008551 hexamer interface [polypeptide binding]; other site 882097008552 metal binding site [ion binding]; metal-binding site 882097008553 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 882097008554 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 882097008555 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 882097008556 putative NAD(P) binding site [chemical binding]; other site 882097008557 catalytic Zn binding site [ion binding]; other site 882097008558 structural Zn binding site [ion binding]; other site 882097008559 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 882097008560 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 882097008561 putative NAD(P) binding site [chemical binding]; other site 882097008562 catalytic Zn binding site [ion binding]; other site 882097008563 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 882097008564 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 882097008565 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 882097008566 active site 882097008567 P-loop; other site 882097008568 phosphorylation site [posttranslational modification] 882097008569 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097008570 active site 882097008571 phosphorylation site [posttranslational modification] 882097008572 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882097008573 PRD domain; Region: PRD; pfam00874 882097008574 PRD domain; Region: PRD; pfam00874 882097008575 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882097008576 active site 882097008577 P-loop; other site 882097008578 phosphorylation site [posttranslational modification] 882097008579 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097008580 active site 882097008581 phosphorylation site [posttranslational modification] 882097008582 Predicted membrane protein [Function unknown]; Region: COG4905 882097008583 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 882097008584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 882097008585 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 882097008586 Ligand Binding Site [chemical binding]; other site 882097008587 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 882097008588 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 882097008589 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 882097008590 active site 882097008591 DNA binding site [nucleotide binding] 882097008592 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 882097008593 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 882097008594 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882097008595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882097008596 active site 882097008597 phosphorylation site [posttranslational modification] 882097008598 intermolecular recognition site; other site 882097008599 dimerization interface [polypeptide binding]; other site 882097008600 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882097008601 DNA binding site [nucleotide binding] 882097008602 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 882097008603 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 882097008604 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 882097008605 Ligand Binding Site [chemical binding]; other site 882097008606 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 882097008607 GAF domain; Region: GAF_3; pfam13492 882097008608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882097008609 dimer interface [polypeptide binding]; other site 882097008610 phosphorylation site [posttranslational modification] 882097008611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882097008612 ATP binding site [chemical binding]; other site 882097008613 Mg2+ binding site [ion binding]; other site 882097008614 G-X-G motif; other site 882097008615 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 882097008616 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 882097008617 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882097008618 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 882097008619 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882097008620 active site 882097008621 P-loop; other site 882097008622 phosphorylation site [posttranslational modification] 882097008623 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882097008624 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882097008625 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882097008626 methionine cluster; other site 882097008627 active site 882097008628 phosphorylation site [posttranslational modification] 882097008629 metal binding site [ion binding]; metal-binding site 882097008630 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 882097008631 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 882097008632 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 882097008633 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 882097008634 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882097008635 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 882097008636 Soluble P-type ATPase [General function prediction only]; Region: COG4087 882097008637 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 882097008638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882097008639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882097008640 autolysin; Reviewed; Region: PRK06347 882097008641 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882097008642 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882097008643 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882097008644 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882097008645 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882097008646 Protein of unknown function (DUF970); Region: DUF970; pfam06153 882097008647 thymidylate kinase; Validated; Region: tmk; PRK00698 882097008648 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 882097008649 TMP-binding site; other site 882097008650 ATP-binding site [chemical binding]; other site 882097008651 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 882097008652 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 882097008653 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882097008654 catalytic residue [active] 882097008655 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 882097008656 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 882097008657 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 882097008658 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 882097008659 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 882097008660 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 882097008661 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882097008662 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882097008663 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882097008664 putative active site [active] 882097008665 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882097008666 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097008667 active site 882097008668 motif I; other site 882097008669 motif II; other site 882097008670 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 882097008671 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882097008672 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882097008673 active site 882097008674 catalytic tetrad [active] 882097008675 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 882097008676 recombination protein RecR; Reviewed; Region: recR; PRK00076 882097008677 RecR protein; Region: RecR; pfam02132 882097008678 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 882097008679 putative active site [active] 882097008680 putative metal-binding site [ion binding]; other site 882097008681 tetramer interface [polypeptide binding]; other site 882097008682 hypothetical protein; Validated; Region: PRK00153 882097008683 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 882097008684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882097008685 Walker A motif; other site 882097008686 ATP binding site [chemical binding]; other site 882097008687 Walker B motif; other site 882097008688 arginine finger; other site 882097008689 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 882097008690 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 882097008691 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 882097008692 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882097008693 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882097008694 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 882097008695 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 882097008696 N- and C-terminal domain interface [polypeptide binding]; other site 882097008697 active site 882097008698 catalytic site [active] 882097008699 metal binding site [ion binding]; metal-binding site 882097008700 carbohydrate binding site [chemical binding]; other site 882097008701 ATP binding site [chemical binding]; other site 882097008702 SH3-like domain; Region: SH3_8; pfam13457 882097008703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 882097008704 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 882097008705 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882097008706 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 882097008707 Walker A/P-loop; other site 882097008708 ATP binding site [chemical binding]; other site 882097008709 Q-loop/lid; other site 882097008710 ABC transporter signature motif; other site 882097008711 Walker B; other site 882097008712 D-loop; other site 882097008713 H-loop/switch region; other site 882097008714 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 882097008715 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882097008716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097008717 Walker A/P-loop; other site 882097008718 ATP binding site [chemical binding]; other site 882097008719 Q-loop/lid; other site 882097008720 ABC transporter signature motif; other site 882097008721 Walker B; other site 882097008722 D-loop; other site 882097008723 H-loop/switch region; other site 882097008724 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 882097008725 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 882097008726 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 882097008727 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 882097008728 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 882097008729 nucleoside/Zn binding site; other site 882097008730 dimer interface [polypeptide binding]; other site 882097008731 catalytic motif [active] 882097008732 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 882097008733 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 882097008734 active site 882097008735 acyl-activating enzyme (AAE) consensus motif; other site 882097008736 putative CoA binding site [chemical binding]; other site 882097008737 AMP binding site [chemical binding]; other site 882097008738 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 882097008739 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 882097008740 active site 882097008741 trimer interface [polypeptide binding]; other site 882097008742 allosteric site; other site 882097008743 active site lid [active] 882097008744 hexamer (dimer of trimers) interface [polypeptide binding]; other site 882097008745 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 882097008746 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 882097008747 DNA binding residues [nucleotide binding] 882097008748 drug binding residues [chemical binding]; other site 882097008749 dimer interface [polypeptide binding]; other site 882097008750 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 882097008751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097008752 Coenzyme A binding pocket [chemical binding]; other site 882097008753 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 882097008754 dimer interface [polypeptide binding]; other site 882097008755 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 882097008756 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 882097008757 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882097008758 MarR family; Region: MarR; pfam01047 882097008759 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 882097008760 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 882097008761 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882097008762 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882097008763 DNA binding residues [nucleotide binding] 882097008764 putative dimer interface [polypeptide binding]; other site 882097008765 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 882097008766 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 882097008767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097008768 active site 882097008769 motif I; other site 882097008770 motif II; other site 882097008771 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882097008772 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882097008773 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882097008774 putative active site [active] 882097008775 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 882097008776 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097008777 active site 882097008778 phosphorylation site [posttranslational modification] 882097008779 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882097008780 active site 882097008781 P-loop; other site 882097008782 phosphorylation site [posttranslational modification] 882097008783 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882097008784 alpha-mannosidase; Provisional; Region: PRK09819 882097008785 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 882097008786 active site 882097008787 metal binding site [ion binding]; metal-binding site 882097008788 catalytic site [active] 882097008789 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 882097008790 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 882097008791 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 882097008792 active site 882097008793 homodimer interface [polypeptide binding]; other site 882097008794 catalytic site [active] 882097008795 glycerate kinase; Region: TIGR00045 882097008796 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 882097008797 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882097008798 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882097008799 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882097008800 DNA binding site [nucleotide binding] 882097008801 domain linker motif; other site 882097008802 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 882097008803 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 882097008804 Domain of unknown function DUF21; Region: DUF21; pfam01595 882097008805 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 882097008806 Transporter associated domain; Region: CorC_HlyC; pfam03471 882097008807 NAD-dependent deacetylase; Provisional; Region: PRK00481 882097008808 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 882097008809 NAD+ binding site [chemical binding]; other site 882097008810 substrate binding site [chemical binding]; other site 882097008811 putative Zn binding site [ion binding]; other site 882097008812 Pathogenicity locus; Region: Cdd1; pfam11731 882097008813 drug efflux system protein MdtG; Provisional; Region: PRK09874 882097008814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097008815 putative substrate translocation pore; other site 882097008816 Variant SH3 domain; Region: SH3_2; pfam07653 882097008817 Variant SH3 domain; Region: SH3_2; pfam07653 882097008818 peptide ligand binding site [polypeptide binding]; other site 882097008819 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 882097008820 active site 882097008821 intersubunit interactions; other site 882097008822 catalytic residue [active] 882097008823 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882097008824 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882097008825 ligand binding site [chemical binding]; other site 882097008826 flexible hinge region; other site 882097008827 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882097008828 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882097008829 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882097008830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097008831 Walker A/P-loop; other site 882097008832 ATP binding site [chemical binding]; other site 882097008833 Q-loop/lid; other site 882097008834 ABC transporter signature motif; other site 882097008835 Walker B; other site 882097008836 D-loop; other site 882097008837 H-loop/switch region; other site 882097008838 TfoX C-terminal domain; Region: TfoX_C; pfam04994 882097008839 seryl-tRNA synthetase; Provisional; Region: PRK05431 882097008840 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 882097008841 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 882097008842 dimer interface [polypeptide binding]; other site 882097008843 active site 882097008844 motif 1; other site 882097008845 motif 2; other site 882097008846 motif 3; other site 882097008847 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 882097008848 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 882097008849 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 882097008850 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 882097008851 glutamine binding [chemical binding]; other site 882097008852 catalytic triad [active] 882097008853 aminodeoxychorismate synthase; Provisional; Region: PRK07508 882097008854 chorismate binding enzyme; Region: Chorismate_bind; cl10555 882097008855 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 882097008856 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 882097008857 substrate-cofactor binding pocket; other site 882097008858 homodimer interface [polypeptide binding]; other site 882097008859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882097008860 catalytic residue [active] 882097008861 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882097008862 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882097008863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097008864 Walker A/P-loop; other site 882097008865 ATP binding site [chemical binding]; other site 882097008866 Q-loop/lid; other site 882097008867 ABC transporter signature motif; other site 882097008868 Walker B; other site 882097008869 D-loop; other site 882097008870 H-loop/switch region; other site 882097008871 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882097008872 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882097008873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882097008874 Walker A/P-loop; other site 882097008875 ATP binding site [chemical binding]; other site 882097008876 Q-loop/lid; other site 882097008877 ABC transporter signature motif; other site 882097008878 Walker B; other site 882097008879 D-loop; other site 882097008880 H-loop/switch region; other site 882097008881 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 882097008882 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 882097008883 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 882097008884 Predicted acyl esterases [General function prediction only]; Region: COG2936 882097008885 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 882097008886 DNA topoisomerase III; Provisional; Region: PRK07726 882097008887 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 882097008888 active site 882097008889 putative interdomain interaction site [polypeptide binding]; other site 882097008890 putative metal-binding site [ion binding]; other site 882097008891 putative nucleotide binding site [chemical binding]; other site 882097008892 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 882097008893 domain I; other site 882097008894 DNA binding groove [nucleotide binding] 882097008895 phosphate binding site [ion binding]; other site 882097008896 domain II; other site 882097008897 domain III; other site 882097008898 nucleotide binding site [chemical binding]; other site 882097008899 catalytic site [active] 882097008900 domain IV; other site 882097008901 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 882097008902 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 882097008903 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882097008904 ATP binding site [chemical binding]; other site 882097008905 putative Mg++ binding site [ion binding]; other site 882097008906 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882097008907 nucleotide binding region [chemical binding]; other site 882097008908 ATP-binding site [chemical binding]; other site 882097008909 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 882097008910 HRDC domain; Region: HRDC; pfam00570 882097008911 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 882097008912 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 882097008913 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 882097008914 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 882097008915 active site 882097008916 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 882097008917 putative ADP-ribose binding site [chemical binding]; other site 882097008918 putative active site [active] 882097008919 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 882097008920 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882097008921 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882097008922 ABC transporter; Region: ABC_tran_2; pfam12848 882097008923 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882097008924 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882097008925 beta-galactosidase; Region: BGL; TIGR03356 882097008926 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882097008927 active site 882097008928 P-loop; other site 882097008929 phosphorylation site [posttranslational modification] 882097008930 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882097008931 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882097008932 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882097008933 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882097008934 nucleotide binding site [chemical binding]; other site 882097008935 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882097008936 methionine cluster; other site 882097008937 active site 882097008938 phosphorylation site [posttranslational modification] 882097008939 metal binding site [ion binding]; metal-binding site 882097008940 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882097008941 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882097008942 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882097008943 putative active site [active] 882097008944 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 882097008945 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 882097008946 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 882097008947 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882097008948 Walker A/P-loop; other site 882097008949 ATP binding site [chemical binding]; other site 882097008950 Q-loop/lid; other site 882097008951 ABC transporter signature motif; other site 882097008952 Walker B; other site 882097008953 D-loop; other site 882097008954 H-loop/switch region; other site 882097008955 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 882097008956 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 882097008957 ATP-grasp domain; Region: ATP-grasp_4; cl17255 882097008958 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 882097008959 beta-galactosidase; Region: BGL; TIGR03356 882097008960 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 882097008961 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882097008962 active site turn [active] 882097008963 phosphorylation site [posttranslational modification] 882097008964 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882097008965 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 882097008966 HPr interaction site; other site 882097008967 glycerol kinase (GK) interaction site [polypeptide binding]; other site 882097008968 active site 882097008969 phosphorylation site [posttranslational modification] 882097008970 transcriptional antiterminator BglG; Provisional; Region: PRK09772 882097008971 CAT RNA binding domain; Region: CAT_RBD; smart01061 882097008972 PRD domain; Region: PRD; pfam00874 882097008973 PRD domain; Region: PRD; pfam00874 882097008974 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882097008975 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 882097008976 Walker A/P-loop; other site 882097008977 ATP binding site [chemical binding]; other site 882097008978 Q-loop/lid; other site 882097008979 ABC transporter signature motif; other site 882097008980 Walker B; other site 882097008981 D-loop; other site 882097008982 H-loop/switch region; other site 882097008983 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 882097008984 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 882097008985 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 882097008986 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 882097008987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097008988 putative substrate translocation pore; other site 882097008989 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 882097008990 GTP-binding protein YchF; Reviewed; Region: PRK09601 882097008991 YchF GTPase; Region: YchF; cd01900 882097008992 G1 box; other site 882097008993 GTP/Mg2+ binding site [chemical binding]; other site 882097008994 Switch I region; other site 882097008995 G2 box; other site 882097008996 Switch II region; other site 882097008997 G3 box; other site 882097008998 G4 box; other site 882097008999 G5 box; other site 882097009000 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 882097009001 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882097009002 methionine cluster; other site 882097009003 active site 882097009004 phosphorylation site [posttranslational modification] 882097009005 metal binding site [ion binding]; metal-binding site 882097009006 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 882097009007 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 882097009008 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 882097009009 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882097009010 active site 882097009011 P-loop; other site 882097009012 phosphorylation site [posttranslational modification] 882097009013 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882097009014 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 882097009015 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882097009016 HTH domain; Region: HTH_11; pfam08279 882097009017 Mga helix-turn-helix domain; Region: Mga; pfam05043 882097009018 PRD domain; Region: PRD; pfam00874 882097009019 PRD domain; Region: PRD; pfam00874 882097009020 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882097009021 active site 882097009022 P-loop; other site 882097009023 phosphorylation site [posttranslational modification] 882097009024 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097009025 active site 882097009026 phosphorylation site [posttranslational modification] 882097009027 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 882097009028 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 882097009029 tetramer interface [polypeptide binding]; other site 882097009030 heme binding pocket [chemical binding]; other site 882097009031 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 882097009032 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 882097009033 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882097009034 active site turn [active] 882097009035 phosphorylation site [posttranslational modification] 882097009036 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882097009037 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 882097009038 HPr interaction site; other site 882097009039 glycerol kinase (GK) interaction site [polypeptide binding]; other site 882097009040 active site 882097009041 phosphorylation site [posttranslational modification] 882097009042 transcriptional antiterminator BglG; Provisional; Region: PRK09772 882097009043 CAT RNA binding domain; Region: CAT_RBD; pfam03123 882097009044 PRD domain; Region: PRD; pfam00874 882097009045 PRD domain; Region: PRD; pfam00874 882097009046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 882097009047 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 882097009048 ParB-like nuclease domain; Region: ParB; smart00470 882097009049 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 882097009050 salt bridge; other site 882097009051 non-specific DNA binding site [nucleotide binding]; other site 882097009052 sequence-specific DNA binding site [nucleotide binding]; other site 882097009053 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 882097009054 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 882097009055 P-loop; other site 882097009056 Magnesium ion binding site [ion binding]; other site 882097009057 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 882097009058 Magnesium ion binding site [ion binding]; other site 882097009059 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 882097009060 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882097009061 non-specific DNA binding site [nucleotide binding]; other site 882097009062 salt bridge; other site 882097009063 sequence-specific DNA binding site [nucleotide binding]; other site 882097009064 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 882097009065 ParB-like nuclease domain; Region: ParBc; pfam02195 882097009066 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882097009067 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882097009068 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882097009069 putative active site [active] 882097009070 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882097009071 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882097009072 nucleotide binding site [chemical binding]; other site 882097009073 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882097009074 active site 882097009075 phosphorylation site [posttranslational modification] 882097009076 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 882097009077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097009078 motif II; other site 882097009079 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 882097009080 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 882097009081 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 882097009082 active site 882097009083 P-loop; other site 882097009084 phosphorylation site [posttranslational modification] 882097009085 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882097009086 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882097009087 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 882097009088 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 882097009089 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 882097009090 putative active site cavity [active] 882097009091 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 882097009092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882097009093 S-adenosylmethionine binding site [chemical binding]; other site 882097009094 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 882097009095 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 882097009096 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 882097009097 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 882097009098 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 882097009099 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 882097009100 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 882097009101 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 882097009102 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 882097009103 trmE is a tRNA modification GTPase; Region: trmE; cd04164 882097009104 G1 box; other site 882097009105 GTP/Mg2+ binding site [chemical binding]; other site 882097009106 Switch I region; other site 882097009107 G2 box; other site 882097009108 Switch II region; other site 882097009109 G3 box; other site 882097009110 G4 box; other site 882097009111 G5 box; other site 882097009112 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 882097009113 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 882097009114 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 882097009115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882097009116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882097009117 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 882097009118 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 882097009119 NADP binding site [chemical binding]; other site 882097009120 homodimer interface [polypeptide binding]; other site 882097009121 active site 882097009122 substrate binding site [chemical binding]; other site 882097009123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097009124 D-galactonate transporter; Region: 2A0114; TIGR00893 882097009125 putative substrate translocation pore; other site 882097009126 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 882097009127 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 882097009128 metal binding site [ion binding]; metal-binding site 882097009129 dimer interface [polypeptide binding]; other site 882097009130 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 882097009131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 882097009132 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 882097009133 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 882097009134 metal binding site [ion binding]; metal-binding site 882097009135 dimer interface [polypeptide binding]; other site 882097009136 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882097009137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882097009138 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 882097009139 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097009140 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882097009141 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097009142 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097009143 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097009144 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882097009145 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882097009146 Uncharacterized conserved protein [Function unknown]; Region: COG4198 882097009147 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 882097009148 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 882097009149 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 882097009150 putative ligand binding site [chemical binding]; other site 882097009151 putative NAD binding site [chemical binding]; other site 882097009152 putative catalytic site [active] 882097009153 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 882097009154 L-serine binding site [chemical binding]; other site 882097009155 ACT domain interface; other site 882097009156 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 882097009157 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882097009158 catalytic residue [active] 882097009159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097009160 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882097009161 putative substrate translocation pore; other site 882097009162 Transcriptional regulators [Transcription]; Region: MarR; COG1846 882097009163 MarR family; Region: MarR_2; pfam12802 882097009164 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 882097009165 dimer interface [polypeptide binding]; other site 882097009166 FMN binding site [chemical binding]; other site 882097009167 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882097009168 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 882097009169 catalytic residues [active] 882097009170 beta-phosphoglucomutase; Region: bPGM; TIGR01990 882097009171 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 882097009172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882097009173 motif II; other site 882097009174 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 882097009175 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 882097009176 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 882097009177 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 882097009178 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 882097009179 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882097009180 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882097009181 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 882097009182 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 882097009183 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 882097009184 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 882097009185 putative NAD(P) binding site [chemical binding]; other site 882097009186 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882097009187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097009188 dimer interface [polypeptide binding]; other site 882097009189 conserved gate region; other site 882097009190 putative PBP binding loops; other site 882097009191 ABC-ATPase subunit interface; other site 882097009192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882097009193 dimer interface [polypeptide binding]; other site 882097009194 conserved gate region; other site 882097009195 putative PBP binding loops; other site 882097009196 ABC-ATPase subunit interface; other site 882097009197 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 882097009198 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882097009199 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 882097009200 sucrose phosphorylase; Provisional; Region: PRK13840 882097009201 active site 882097009202 homodimer interface [polypeptide binding]; other site 882097009203 catalytic site [active] 882097009204 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882097009205 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882097009206 DNA binding site [nucleotide binding] 882097009207 domain linker motif; other site 882097009208 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 882097009209 putative dimerization interface [polypeptide binding]; other site 882097009210 putative ligand binding site [chemical binding]; other site 882097009211 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 882097009212 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 882097009213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882097009214 Coenzyme A binding pocket [chemical binding]; other site 882097009215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097009216 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882097009217 putative substrate translocation pore; other site 882097009218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097009219 Domain of unknown function (DUF718); Region: DUF718; cl01281 882097009220 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 882097009221 intersubunit interface [polypeptide binding]; other site 882097009222 active site 882097009223 Zn2+ binding site [ion binding]; other site 882097009224 L-rhamnose isomerase; Provisional; Region: PRK01076 882097009225 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 882097009226 N- and C-terminal domain interface [polypeptide binding]; other site 882097009227 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 882097009228 active site 882097009229 putative catalytic site [active] 882097009230 metal binding site [ion binding]; metal-binding site 882097009231 ATP binding site [chemical binding]; other site 882097009232 carbohydrate binding site [chemical binding]; other site 882097009233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882097009234 putative substrate translocation pore; other site 882097009235 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882097009236 Cupin domain; Region: Cupin_2; pfam07883 882097009237 Helix-turn-helix domain; Region: HTH_18; pfam12833 882097009238 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 882097009239 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 882097009240 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 882097009241 G-X-X-G motif; other site 882097009242 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 882097009243 RxxxH motif; other site 882097009244 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 882097009245 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 882097009246 ribonuclease P; Reviewed; Region: rnpA; PRK00499 882097009247 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399