-- dump date 20140619_134327 -- class Genbank::misc_feature -- table misc_feature_note -- id note 879089000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 879089000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 879089000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089000004 Walker A motif; other site 879089000005 ATP binding site [chemical binding]; other site 879089000006 Walker B motif; other site 879089000007 arginine finger; other site 879089000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 879089000009 DnaA box-binding interface [nucleotide binding]; other site 879089000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 879089000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 879089000012 putative DNA binding surface [nucleotide binding]; other site 879089000013 dimer interface [polypeptide binding]; other site 879089000014 beta-clamp/clamp loader binding surface; other site 879089000015 beta-clamp/translesion DNA polymerase binding surface; other site 879089000016 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 879089000017 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 879089000018 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 879089000019 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 879089000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 879089000021 Walker A/P-loop; other site 879089000022 ATP binding site [chemical binding]; other site 879089000023 Q-loop/lid; other site 879089000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089000025 ABC transporter signature motif; other site 879089000026 Walker B; other site 879089000027 D-loop; other site 879089000028 H-loop/switch region; other site 879089000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 879089000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089000031 Mg2+ binding site [ion binding]; other site 879089000032 G-X-G motif; other site 879089000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 879089000034 anchoring element; other site 879089000035 dimer interface [polypeptide binding]; other site 879089000036 ATP binding site [chemical binding]; other site 879089000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 879089000038 active site 879089000039 putative metal-binding site [ion binding]; other site 879089000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 879089000041 DNA gyrase subunit A; Validated; Region: PRK05560 879089000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 879089000043 CAP-like domain; other site 879089000044 active site 879089000045 primary dimer interface [polypeptide binding]; other site 879089000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 879089000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 879089000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 879089000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 879089000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 879089000051 cardiolipin synthetase; Reviewed; Region: PRK12452 879089000052 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 879089000053 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 879089000054 putative active site [active] 879089000055 catalytic site [active] 879089000056 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 879089000057 putative active site [active] 879089000058 catalytic site [active] 879089000059 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 879089000060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089000061 Coenzyme A binding pocket [chemical binding]; other site 879089000062 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 879089000063 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 879089000064 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 879089000065 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 879089000066 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 879089000067 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 879089000068 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 879089000069 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 879089000070 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 879089000071 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 879089000072 D-pathway; other site 879089000073 Putative ubiquinol binding site [chemical binding]; other site 879089000074 Low-spin heme (heme b) binding site [chemical binding]; other site 879089000075 Putative water exit pathway; other site 879089000076 Binuclear center (heme o3/CuB) [ion binding]; other site 879089000077 K-pathway; other site 879089000078 Putative proton exit pathway; other site 879089000079 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 879089000080 Subunit I/III interface [polypeptide binding]; other site 879089000081 Subunit III/IV interface [polypeptide binding]; other site 879089000082 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 879089000083 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 879089000084 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 879089000085 putative active site [active] 879089000086 putative metal binding site [ion binding]; other site 879089000087 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 879089000088 beta-galactosidase; Region: BGL; TIGR03356 879089000089 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 879089000090 Bacterial SH3 domain; Region: SH3_3; pfam08239 879089000091 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 879089000092 putative active site [active] 879089000093 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 879089000094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089000095 DNA-binding site [nucleotide binding]; DNA binding site 879089000096 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 879089000097 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 879089000098 active site 879089000099 active pocket/dimerization site; other site 879089000100 phosphorylation site [posttranslational modification] 879089000101 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 879089000102 active site 879089000103 phosphorylation site [posttranslational modification] 879089000104 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 879089000105 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 879089000106 hypothetical protein; Provisional; Region: PRK02947 879089000107 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 879089000108 putative active site [active] 879089000109 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 879089000110 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 879089000111 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 879089000112 active site turn [active] 879089000113 phosphorylation site [posttranslational modification] 879089000114 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 879089000115 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 879089000116 HPr interaction site; other site 879089000117 glycerol kinase (GK) interaction site [polypeptide binding]; other site 879089000118 active site 879089000119 phosphorylation site [posttranslational modification] 879089000120 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 879089000121 putative dimer interface [polypeptide binding]; other site 879089000122 catalytic triad [active] 879089000123 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089000124 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 879089000125 Walker A/P-loop; other site 879089000126 ATP binding site [chemical binding]; other site 879089000127 Q-loop/lid; other site 879089000128 ABC transporter signature motif; other site 879089000129 Walker B; other site 879089000130 D-loop; other site 879089000131 H-loop/switch region; other site 879089000132 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 879089000133 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 879089000134 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 879089000135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089000136 active site 879089000137 motif I; other site 879089000138 motif II; other site 879089000139 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089000140 Transcriptional regulators [Transcription]; Region: PurR; COG1609 879089000141 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 879089000142 DNA binding site [nucleotide binding] 879089000143 domain linker motif; other site 879089000144 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 879089000145 dimerization interface [polypeptide binding]; other site 879089000146 putative ligand binding site [chemical binding]; other site 879089000147 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 879089000148 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 879089000149 nucleotide binding site [chemical binding]; other site 879089000150 Butyrate kinase [Energy production and conversion]; Region: COG3426 879089000151 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 879089000152 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 879089000153 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 879089000154 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 879089000155 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 879089000156 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 879089000157 dimer interface [polypeptide binding]; other site 879089000158 active site 879089000159 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 879089000160 dimer interface [polypeptide binding]; other site 879089000161 active site 879089000162 putrescine carbamoyltransferase; Provisional; Region: PRK02255 879089000163 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 879089000164 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 879089000165 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 879089000166 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 879089000167 agmatine deiminase; Provisional; Region: PRK13551 879089000168 agmatine deiminase; Region: agmatine_aguA; TIGR03380 879089000169 carbamate kinase; Reviewed; Region: PRK12686 879089000170 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 879089000171 putative substrate binding site [chemical binding]; other site 879089000172 nucleotide binding site [chemical binding]; other site 879089000173 nucleotide binding site [chemical binding]; other site 879089000174 homodimer interface [polypeptide binding]; other site 879089000175 agmatine deiminase; Provisional; Region: PRK13551 879089000176 agmatine deiminase; Region: agmatine_aguA; TIGR03380 879089000177 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 879089000178 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 879089000179 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 879089000180 putative active site [active] 879089000181 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 879089000182 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 879089000183 arginine deiminase; Provisional; Region: PRK01388 879089000184 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 879089000185 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 879089000186 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 879089000187 dimer interface [polypeptide binding]; other site 879089000188 ssDNA binding site [nucleotide binding]; other site 879089000189 tetramer (dimer of dimers) interface [polypeptide binding]; other site 879089000190 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 879089000191 Predicted membrane protein [Function unknown]; Region: COG3212 879089000192 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 879089000193 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 879089000194 putative accessory gene regulator protein; Provisional; Region: PRK01100 879089000195 Staphylococcal AgrD protein; Region: AgrD; cl05477 879089000196 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 879089000197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089000198 ATP binding site [chemical binding]; other site 879089000199 Mg2+ binding site [ion binding]; other site 879089000200 G-X-G motif; other site 879089000201 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 879089000202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089000203 active site 879089000204 phosphorylation site [posttranslational modification] 879089000205 intermolecular recognition site; other site 879089000206 LytTr DNA-binding domain; Region: LytTR; pfam04397 879089000207 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 879089000208 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 879089000209 DHH family; Region: DHH; pfam01368 879089000210 DHHA1 domain; Region: DHHA1; pfam02272 879089000211 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 879089000212 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 879089000213 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 879089000214 replicative DNA helicase; Provisional; Region: PRK05748 879089000215 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 879089000216 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 879089000217 Walker A motif; other site 879089000218 ATP binding site [chemical binding]; other site 879089000219 Walker B motif; other site 879089000220 DNA binding loops [nucleotide binding] 879089000221 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 879089000222 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 879089000223 GDP-binding site [chemical binding]; other site 879089000224 ACT binding site; other site 879089000225 IMP binding site; other site 879089000226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 879089000227 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 879089000228 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 879089000229 Predicted membrane protein [Function unknown]; Region: COG1511 879089000230 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 879089000231 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 879089000232 Uncharacterized small protein [Function unknown]; Region: COG5417 879089000233 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 879089000234 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 879089000235 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 879089000236 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 879089000237 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 879089000238 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 879089000239 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 879089000240 Uncharacterized conserved protein [Function unknown]; Region: COG5444 879089000241 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 879089000242 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 879089000243 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 879089000244 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 879089000245 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 879089000246 tetramer interface [polypeptide binding]; other site 879089000247 active site 879089000248 Mg2+/Mn2+ binding site [ion binding]; other site 879089000249 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 879089000250 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 879089000251 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 879089000252 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 879089000253 DNA binding site [nucleotide binding] 879089000254 active site 879089000255 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 879089000256 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 879089000257 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 879089000258 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 879089000259 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 879089000260 putative ligand binding site [chemical binding]; other site 879089000261 putative NAD binding site [chemical binding]; other site 879089000262 catalytic site [active] 879089000263 LXG domain of WXG superfamily; Region: LXG; pfam04740 879089000264 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 879089000265 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 879089000266 DNA binding residues [nucleotide binding] 879089000267 putative dimer interface [polypeptide binding]; other site 879089000268 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 879089000269 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 879089000270 active site 879089000271 catalytic tetrad [active] 879089000272 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089000273 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 879089000274 ATP synthase subunit C; Region: ATP-synt_C; cl00466 879089000275 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 879089000276 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 879089000277 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 879089000278 Walker A motif; other site 879089000279 ATP binding site [chemical binding]; other site 879089000280 Walker B motif; other site 879089000281 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 879089000282 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 879089000283 core domain interface [polypeptide binding]; other site 879089000284 delta subunit interface [polypeptide binding]; other site 879089000285 epsilon subunit interface [polypeptide binding]; other site 879089000286 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 879089000287 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 879089000288 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 879089000289 alpha subunit interaction interface [polypeptide binding]; other site 879089000290 Walker A motif; other site 879089000291 ATP binding site [chemical binding]; other site 879089000292 Walker B motif; other site 879089000293 inhibitor binding site; inhibition site 879089000294 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 879089000295 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 879089000296 gamma subunit interface [polypeptide binding]; other site 879089000297 epsilon subunit interface [polypeptide binding]; other site 879089000298 LBP interface [polypeptide binding]; other site 879089000299 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 879089000300 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 879089000301 active pocket/dimerization site; other site 879089000302 active site 879089000303 phosphorylation site [posttranslational modification] 879089000304 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 879089000305 active site 879089000306 phosphorylation site [posttranslational modification] 879089000307 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 879089000308 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 879089000309 Domain of unknown function (DUF956); Region: DUF956; pfam06115 879089000310 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 879089000311 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 879089000312 dimerization interface [polypeptide binding]; other site 879089000313 putative DNA binding site [nucleotide binding]; other site 879089000314 putative Zn2+ binding site [ion binding]; other site 879089000315 Uncharacterized conserved protein [Function unknown]; Region: COG1359 879089000316 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 879089000317 dimer interface [polypeptide binding]; other site 879089000318 FMN binding site [chemical binding]; other site 879089000319 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 879089000320 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 879089000321 active site 879089000322 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 879089000323 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 879089000324 Interdomain contacts; other site 879089000325 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 879089000326 aromatic chitin/cellulose binding site residues [chemical binding]; other site 879089000327 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 879089000328 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 879089000329 nucleotide binding site [chemical binding]; other site 879089000330 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 879089000331 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 879089000332 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 879089000333 Walker A/P-loop; other site 879089000334 ATP binding site [chemical binding]; other site 879089000335 Q-loop/lid; other site 879089000336 ABC transporter signature motif; other site 879089000337 Walker B; other site 879089000338 D-loop; other site 879089000339 H-loop/switch region; other site 879089000340 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 879089000341 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 879089000342 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 879089000343 Walker A/P-loop; other site 879089000344 ATP binding site [chemical binding]; other site 879089000345 Q-loop/lid; other site 879089000346 ABC transporter signature motif; other site 879089000347 Walker B; other site 879089000348 D-loop; other site 879089000349 H-loop/switch region; other site 879089000350 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 879089000351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 879089000352 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 879089000353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 879089000354 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 879089000355 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 879089000356 substrate binding pocket [chemical binding]; other site 879089000357 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 879089000358 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 879089000359 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089000360 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 879089000361 ligand binding site [chemical binding]; other site 879089000362 flexible hinge region; other site 879089000363 Domain of unknown function (DUF955); Region: DUF955; pfam06114 879089000364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089000365 non-specific DNA binding site [nucleotide binding]; other site 879089000366 salt bridge; other site 879089000367 sequence-specific DNA binding site [nucleotide binding]; other site 879089000368 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 879089000369 Predicted secreted protein [Function unknown]; Region: COG5437 879089000370 Phage-related protein [Function unknown]; Region: COG5412 879089000371 Phage tail protein; Region: Sipho_tail; pfam05709 879089000372 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 879089000373 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 879089000374 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 879089000375 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 879089000376 active site 879089000377 metal binding site [ion binding]; metal-binding site 879089000378 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 879089000379 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 879089000380 putative active site [active] 879089000381 putative metal binding site [ion binding]; other site 879089000382 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 879089000383 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 879089000384 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 879089000385 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 879089000386 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 879089000387 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 879089000388 active site 879089000389 Uncharacterized conserved protein [Function unknown]; Region: COG3592 879089000390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089000391 Coenzyme A binding pocket [chemical binding]; other site 879089000392 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 879089000393 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 879089000394 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 879089000395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089000396 dimer interface [polypeptide binding]; other site 879089000397 conserved gate region; other site 879089000398 putative PBP binding loops; other site 879089000399 ABC-ATPase subunit interface; other site 879089000400 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 879089000401 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 879089000402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089000403 dimer interface [polypeptide binding]; other site 879089000404 conserved gate region; other site 879089000405 putative PBP binding loops; other site 879089000406 ABC-ATPase subunit interface; other site 879089000407 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 879089000408 LXG domain of WXG superfamily; Region: LXG; pfam04740 879089000409 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 879089000410 phosphoenolpyruvate synthase; Validated; Region: PRK06464 879089000411 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 879089000412 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 879089000413 peptide binding site [polypeptide binding]; other site 879089000414 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 879089000415 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 879089000416 metal binding site [ion binding]; metal-binding site 879089000417 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 879089000418 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 879089000419 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 879089000420 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 879089000421 ABC-ATPase subunit interface; other site 879089000422 dimer interface [polypeptide binding]; other site 879089000423 putative PBP binding regions; other site 879089000424 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 879089000425 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089000426 ligand binding site [chemical binding]; other site 879089000427 flexible hinge region; other site 879089000428 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 879089000429 DEAD_2; Region: DEAD_2; pfam06733 879089000430 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 879089000431 sugar phosphate phosphatase; Provisional; Region: PRK10513 879089000432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089000433 active site 879089000434 motif I; other site 879089000435 motif II; other site 879089000436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089000437 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 879089000438 Collagen binding domain; Region: Collagen_bind; pfam05737 879089000439 Cna protein B-type domain; Region: Cna_B; pfam05738 879089000440 Cna protein B-type domain; Region: Cna_B; pfam05738 879089000441 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 879089000442 Collagen binding domain; Region: Collagen_bind; pfam05737 879089000443 Cna protein B-type domain; Region: Cna_B; pfam05738 879089000444 Cna protein B-type domain; Region: Cna_B; pfam05738 879089000445 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 879089000446 DNA polymerase III subunit delta'; Validated; Region: PRK08058 879089000447 DNA polymerase III subunit delta'; Validated; Region: PRK08485 879089000448 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 879089000449 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 879089000450 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 879089000451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089000452 S-adenosylmethionine binding site [chemical binding]; other site 879089000453 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 879089000454 GIY-YIG motif/motif A; other site 879089000455 putative active site [active] 879089000456 putative metal binding site [ion binding]; other site 879089000457 Predicted methyltransferases [General function prediction only]; Region: COG0313 879089000458 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 879089000459 putative SAM binding site [chemical binding]; other site 879089000460 putative homodimer interface [polypeptide binding]; other site 879089000461 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 879089000462 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 879089000463 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 879089000464 Uncharacterized conserved protein [Function unknown]; Region: COG5361 879089000465 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 879089000466 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 879089000467 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089000468 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 879089000469 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 879089000470 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 879089000471 active site 879089000472 HIGH motif; other site 879089000473 KMSKS motif; other site 879089000474 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 879089000475 tRNA binding surface [nucleotide binding]; other site 879089000476 anticodon binding site; other site 879089000477 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 879089000478 dimer interface [polypeptide binding]; other site 879089000479 putative tRNA-binding site [nucleotide binding]; other site 879089000480 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 879089000481 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 879089000482 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 879089000483 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 879089000484 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 879089000485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089000486 dimer interface [polypeptide binding]; other site 879089000487 conserved gate region; other site 879089000488 putative PBP binding loops; other site 879089000489 ABC-ATPase subunit interface; other site 879089000490 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 879089000491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089000492 dimer interface [polypeptide binding]; other site 879089000493 conserved gate region; other site 879089000494 putative PBP binding loops; other site 879089000495 ABC-ATPase subunit interface; other site 879089000496 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 879089000497 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 879089000498 alpha-glucosidase; Provisional; Region: PRK10426 879089000499 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 879089000500 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 879089000501 active site 879089000502 catalytic site [active] 879089000503 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 879089000504 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 879089000505 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 879089000506 trimer interface [polypeptide binding]; other site 879089000507 active site 879089000508 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 879089000509 catalytic site [active] 879089000510 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 879089000511 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 879089000512 Ca binding site [ion binding]; other site 879089000513 active site 879089000514 catalytic site [active] 879089000515 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 879089000516 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 879089000517 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 879089000518 active site 879089000519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 879089000520 Domain of unknown function (DUF348); Region: DUF348; pfam03990 879089000521 Domain of unknown function (DUF348); Region: DUF348; pfam03990 879089000522 G5 domain; Region: G5; pfam07501 879089000523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 879089000524 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 879089000525 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 879089000526 putative active site [active] 879089000527 putative metal binding site [ion binding]; other site 879089000528 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 879089000529 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 879089000530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089000531 S-adenosylmethionine binding site [chemical binding]; other site 879089000532 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 879089000533 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 879089000534 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 879089000535 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 879089000536 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 879089000537 putative active site [active] 879089000538 YdjC motif; other site 879089000539 Mg binding site [ion binding]; other site 879089000540 putative homodimer interface [polypeptide binding]; other site 879089000541 pur operon repressor; Provisional; Region: PRK09213 879089000542 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 879089000543 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 879089000544 active site 879089000545 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 879089000546 HlyD family secretion protein; Region: HlyD_3; pfam13437 879089000547 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 879089000548 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 879089000549 Walker A/P-loop; other site 879089000550 ATP binding site [chemical binding]; other site 879089000551 Q-loop/lid; other site 879089000552 ABC transporter signature motif; other site 879089000553 Walker B; other site 879089000554 D-loop; other site 879089000555 H-loop/switch region; other site 879089000556 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 879089000557 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 879089000558 FtsX-like permease family; Region: FtsX; pfam02687 879089000559 regulatory protein SpoVG; Reviewed; Region: PRK13259 879089000560 regulatory protein SpoVG; Reviewed; Region: PRK13259 879089000561 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 879089000562 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 879089000563 Substrate binding site; other site 879089000564 Mg++ binding site; other site 879089000565 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 879089000566 active site 879089000567 substrate binding site [chemical binding]; other site 879089000568 CoA binding site [chemical binding]; other site 879089000569 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 879089000570 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 879089000571 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 879089000572 active site 879089000573 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089000574 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 879089000575 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 879089000576 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 879089000577 active site 879089000578 catalytic site [active] 879089000579 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 879089000580 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 879089000581 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 879089000582 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 879089000583 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 879089000584 active site 879089000585 Zn binding site [ion binding]; other site 879089000586 ActA Protein; Region: ActA; pfam05058 879089000587 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 879089000588 Zn binding site [ion binding]; other site 879089000589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 879089000590 hypothetical protein; Provisional; Region: PRK01119 879089000591 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 879089000592 A new structural DNA glycosylase; Region: AlkD_like; cd06561 879089000593 active site 879089000594 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 879089000595 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 879089000596 tetramer (dimer of dimers) interface [polypeptide binding]; other site 879089000597 NAD binding site [chemical binding]; other site 879089000598 dimer interface [polypeptide binding]; other site 879089000599 substrate binding site [chemical binding]; other site 879089000600 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 879089000601 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 879089000602 5S rRNA interface [nucleotide binding]; other site 879089000603 CTC domain interface [polypeptide binding]; other site 879089000604 L16 interface [polypeptide binding]; other site 879089000605 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 879089000606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089000607 Coenzyme A binding pocket [chemical binding]; other site 879089000608 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 879089000609 putative active site [active] 879089000610 catalytic residue [active] 879089000611 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 879089000612 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 879089000613 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 879089000614 ATP binding site [chemical binding]; other site 879089000615 putative Mg++ binding site [ion binding]; other site 879089000616 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 879089000617 nucleotide binding region [chemical binding]; other site 879089000618 ATP-binding site [chemical binding]; other site 879089000619 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 879089000620 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 879089000621 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 879089000622 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 879089000623 RNA binding surface [nucleotide binding]; other site 879089000624 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 879089000625 Septum formation initiator; Region: DivIC; pfam04977 879089000626 hypothetical protein; Provisional; Region: PRK08582 879089000627 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 879089000628 RNA binding site [nucleotide binding]; other site 879089000629 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 879089000630 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 879089000631 Ligand Binding Site [chemical binding]; other site 879089000632 TilS substrate C-terminal domain; Region: TilS_C; smart00977 879089000633 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 879089000634 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 879089000635 active site 879089000636 FtsH Extracellular; Region: FtsH_ext; pfam06480 879089000637 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 879089000638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089000639 Walker A motif; other site 879089000640 ATP binding site [chemical binding]; other site 879089000641 Walker B motif; other site 879089000642 arginine finger; other site 879089000643 Peptidase family M41; Region: Peptidase_M41; pfam01434 879089000644 pantothenate kinase; Reviewed; Region: PRK13318 879089000645 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 879089000646 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 879089000647 dimerization interface [polypeptide binding]; other site 879089000648 domain crossover interface; other site 879089000649 redox-dependent activation switch; other site 879089000650 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 879089000651 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 879089000652 dimer interface [polypeptide binding]; other site 879089000653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089000654 catalytic residue [active] 879089000655 dihydropteroate synthase; Region: DHPS; TIGR01496 879089000656 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 879089000657 substrate binding pocket [chemical binding]; other site 879089000658 dimer interface [polypeptide binding]; other site 879089000659 inhibitor binding site; inhibition site 879089000660 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 879089000661 homooctamer interface [polypeptide binding]; other site 879089000662 active site 879089000663 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 879089000664 catalytic center binding site [active] 879089000665 ATP binding site [chemical binding]; other site 879089000666 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 879089000667 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 879089000668 FMN binding site [chemical binding]; other site 879089000669 active site 879089000670 catalytic residues [active] 879089000671 substrate binding site [chemical binding]; other site 879089000672 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 879089000673 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 879089000674 dimer interface [polypeptide binding]; other site 879089000675 putative anticodon binding site; other site 879089000676 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 879089000677 motif 1; other site 879089000678 active site 879089000679 motif 2; other site 879089000680 motif 3; other site 879089000681 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 879089000682 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 879089000683 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 879089000684 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 879089000685 ADP binding site [chemical binding]; other site 879089000686 phosphagen binding site; other site 879089000687 substrate specificity loop; other site 879089000688 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 879089000689 Clp amino terminal domain; Region: Clp_N; pfam02861 879089000690 Clp amino terminal domain; Region: Clp_N; pfam02861 879089000691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089000692 Walker A motif; other site 879089000693 ATP binding site [chemical binding]; other site 879089000694 Walker B motif; other site 879089000695 arginine finger; other site 879089000696 UvrB/uvrC motif; Region: UVR; pfam02151 879089000697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089000698 Walker A motif; other site 879089000699 ATP binding site [chemical binding]; other site 879089000700 Walker B motif; other site 879089000701 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 879089000702 DNA repair protein RadA; Provisional; Region: PRK11823 879089000703 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 879089000704 Walker A motif/ATP binding site; other site 879089000705 ATP binding site [chemical binding]; other site 879089000706 Walker B motif; other site 879089000707 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 879089000708 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 879089000709 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 879089000710 putative active site [active] 879089000711 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 879089000712 substrate binding site; other site 879089000713 dimer interface; other site 879089000714 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 879089000715 homotrimer interaction site [polypeptide binding]; other site 879089000716 zinc binding site [ion binding]; other site 879089000717 CDP-binding sites; other site 879089000718 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 879089000719 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 879089000720 HIGH motif; other site 879089000721 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 879089000722 active site 879089000723 KMSKS motif; other site 879089000724 serine O-acetyltransferase; Region: cysE; TIGR01172 879089000725 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 879089000726 trimer interface [polypeptide binding]; other site 879089000727 active site 879089000728 substrate binding site [chemical binding]; other site 879089000729 CoA binding site [chemical binding]; other site 879089000730 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 879089000731 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 879089000732 active site 879089000733 HIGH motif; other site 879089000734 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 879089000735 KMSKS motif; other site 879089000736 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 879089000737 tRNA binding surface [nucleotide binding]; other site 879089000738 anticodon binding site; other site 879089000739 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 879089000740 active site 879089000741 metal binding site [ion binding]; metal-binding site 879089000742 dimerization interface [polypeptide binding]; other site 879089000743 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 879089000744 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 879089000745 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 879089000746 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 879089000747 RNA polymerase factor sigma-70; Validated; Region: PRK08295 879089000748 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 879089000749 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 879089000750 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 879089000751 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 879089000752 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 879089000753 putative homodimer interface [polypeptide binding]; other site 879089000754 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 879089000755 heterodimer interface [polypeptide binding]; other site 879089000756 homodimer interface [polypeptide binding]; other site 879089000757 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 879089000758 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 879089000759 23S rRNA interface [nucleotide binding]; other site 879089000760 L7/L12 interface [polypeptide binding]; other site 879089000761 putative thiostrepton binding site; other site 879089000762 L25 interface [polypeptide binding]; other site 879089000763 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 879089000764 mRNA/rRNA interface [nucleotide binding]; other site 879089000765 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 879089000766 23S rRNA interface [nucleotide binding]; other site 879089000767 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 879089000768 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 879089000769 core dimer interface [polypeptide binding]; other site 879089000770 peripheral dimer interface [polypeptide binding]; other site 879089000771 L10 interface [polypeptide binding]; other site 879089000772 L11 interface [polypeptide binding]; other site 879089000773 putative EF-Tu interaction site [polypeptide binding]; other site 879089000774 putative EF-G interaction site [polypeptide binding]; other site 879089000775 Methyltransferase domain; Region: Methyltransf_31; pfam13847 879089000776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089000777 S-adenosylmethionine binding site [chemical binding]; other site 879089000778 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 879089000779 Transcriptional regulators [Transcription]; Region: PurR; COG1609 879089000780 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 879089000781 DNA binding site [nucleotide binding] 879089000782 domain linker motif; other site 879089000783 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 879089000784 putative dimerization interface [polypeptide binding]; other site 879089000785 putative ligand binding site [chemical binding]; other site 879089000786 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 879089000787 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 879089000788 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 879089000789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089000790 dimer interface [polypeptide binding]; other site 879089000791 conserved gate region; other site 879089000792 putative PBP binding loops; other site 879089000793 ABC-ATPase subunit interface; other site 879089000794 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 879089000795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089000796 dimer interface [polypeptide binding]; other site 879089000797 conserved gate region; other site 879089000798 putative PBP binding loops; other site 879089000799 ABC-ATPase subunit interface; other site 879089000800 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 879089000801 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 879089000802 Ca binding site [ion binding]; other site 879089000803 active site 879089000804 catalytic site [active] 879089000805 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 879089000806 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 879089000807 active site 879089000808 homodimer interface [polypeptide binding]; other site 879089000809 catalytic site [active] 879089000810 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 879089000811 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 879089000812 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 879089000813 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 879089000814 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 879089000815 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 879089000816 RPB10 interaction site [polypeptide binding]; other site 879089000817 RPB1 interaction site [polypeptide binding]; other site 879089000818 RPB11 interaction site [polypeptide binding]; other site 879089000819 RPB3 interaction site [polypeptide binding]; other site 879089000820 RPB12 interaction site [polypeptide binding]; other site 879089000821 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 879089000822 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 879089000823 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 879089000824 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 879089000825 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 879089000826 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 879089000827 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 879089000828 G-loop; other site 879089000829 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 879089000830 DNA binding site [nucleotide binding] 879089000831 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 879089000832 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 879089000833 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089000834 active site 879089000835 motif I; other site 879089000836 motif II; other site 879089000837 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 879089000838 beta-galactosidase; Region: BGL; TIGR03356 879089000839 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 879089000840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 879089000841 Walker A/P-loop; other site 879089000842 ATP binding site [chemical binding]; other site 879089000843 Q-loop/lid; other site 879089000844 ABC transporter signature motif; other site 879089000845 Walker B; other site 879089000846 D-loop; other site 879089000847 H-loop/switch region; other site 879089000848 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 879089000849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089000850 Walker A/P-loop; other site 879089000851 ATP binding site [chemical binding]; other site 879089000852 Q-loop/lid; other site 879089000853 ABC transporter signature motif; other site 879089000854 Walker B; other site 879089000855 D-loop; other site 879089000856 H-loop/switch region; other site 879089000857 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 879089000858 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 879089000859 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 879089000860 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 879089000861 LRR adjacent; Region: LRR_adjacent; pfam08191 879089000862 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089000863 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089000864 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089000865 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 879089000866 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 879089000867 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000868 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000869 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000870 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000871 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000872 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000873 LRR adjacent; Region: LRR_adjacent; pfam08191 879089000874 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089000875 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089000876 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 879089000877 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000878 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000879 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 879089000880 Leucine-rich repeats; other site 879089000881 Substrate binding site [chemical binding]; other site 879089000882 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000883 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000884 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000885 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000886 LRR adjacent; Region: LRR_adjacent; pfam08191 879089000887 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089000888 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089000889 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 879089000890 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 879089000891 metal binding site [ion binding]; metal-binding site 879089000892 dimer interface [polypeptide binding]; other site 879089000893 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 879089000894 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 879089000895 putative Zn2+ binding site [ion binding]; other site 879089000896 putative DNA binding site [nucleotide binding]; other site 879089000897 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 879089000898 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 879089000899 Zn binding site [ion binding]; other site 879089000900 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 879089000901 Zn binding site [ion binding]; other site 879089000902 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 879089000903 catalytic core [active] 879089000904 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 879089000905 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 879089000906 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 879089000907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089000908 dimer interface [polypeptide binding]; other site 879089000909 conserved gate region; other site 879089000910 ABC-ATPase subunit interface; other site 879089000911 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 879089000912 Substrate binding site [chemical binding]; other site 879089000913 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000914 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000915 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000916 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000917 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089000918 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 879089000919 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 879089000920 beta-galactosidase; Region: BGL; TIGR03356 879089000921 sugar phosphate phosphatase; Provisional; Region: PRK10513 879089000922 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089000923 active site 879089000924 motif I; other site 879089000925 motif II; other site 879089000926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089000927 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089000928 Coenzyme A binding pocket [chemical binding]; other site 879089000929 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089000930 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 879089000931 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 879089000932 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 879089000933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089000934 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 879089000935 active site 879089000936 motif I; other site 879089000937 motif II; other site 879089000938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089000939 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 879089000940 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 879089000941 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 879089000942 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 879089000943 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 879089000944 Walker A/P-loop; other site 879089000945 ATP binding site [chemical binding]; other site 879089000946 Q-loop/lid; other site 879089000947 ABC transporter signature motif; other site 879089000948 Walker B; other site 879089000949 D-loop; other site 879089000950 H-loop/switch region; other site 879089000951 TOBE domain; Region: TOBE; pfam03459 879089000952 ATP cone domain; Region: ATP-cone; pfam03477 879089000953 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 879089000954 Class III ribonucleotide reductase; Region: RNR_III; cd01675 879089000955 effector binding site; other site 879089000956 active site 879089000957 Zn binding site [ion binding]; other site 879089000958 glycine loop; other site 879089000959 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 879089000960 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 879089000961 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089000962 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 879089000963 ligand binding site [chemical binding]; other site 879089000964 flexible hinge region; other site 879089000965 Predicted amidohydrolase [General function prediction only]; Region: COG0388 879089000966 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 879089000967 putative active site [active] 879089000968 catalytic triad [active] 879089000969 putative dimer interface [polypeptide binding]; other site 879089000970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089000971 dimer interface [polypeptide binding]; other site 879089000972 conserved gate region; other site 879089000973 ABC-ATPase subunit interface; other site 879089000974 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 879089000975 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 879089000976 Walker A/P-loop; other site 879089000977 ATP binding site [chemical binding]; other site 879089000978 Q-loop/lid; other site 879089000979 ABC transporter signature motif; other site 879089000980 Walker B; other site 879089000981 D-loop; other site 879089000982 H-loop/switch region; other site 879089000983 NIL domain; Region: NIL; pfam09383 879089000984 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 879089000985 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 879089000986 transaminase; Reviewed; Region: PRK08068 879089000987 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 879089000988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089000989 homodimer interface [polypeptide binding]; other site 879089000990 catalytic residue [active] 879089000991 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 879089000992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089000993 active site 879089000994 phosphorylation site [posttranslational modification] 879089000995 intermolecular recognition site; other site 879089000996 dimerization interface [polypeptide binding]; other site 879089000997 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 879089000998 DNA binding site [nucleotide binding] 879089000999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 879089001000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 879089001001 dimerization interface [polypeptide binding]; other site 879089001002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 879089001003 putative active site [active] 879089001004 heme pocket [chemical binding]; other site 879089001005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 879089001006 dimer interface [polypeptide binding]; other site 879089001007 phosphorylation site [posttranslational modification] 879089001008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089001009 ATP binding site [chemical binding]; other site 879089001010 Mg2+ binding site [ion binding]; other site 879089001011 G-X-G motif; other site 879089001012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 879089001013 YycH protein; Region: YycH; pfam07435 879089001014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 879089001015 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 879089001016 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 879089001017 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 879089001018 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 879089001019 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 879089001020 protein binding site [polypeptide binding]; other site 879089001021 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 879089001022 Transcriptional regulator [Transcription]; Region: LysR; COG0583 879089001023 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 879089001024 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 879089001025 dimerization interface [polypeptide binding]; other site 879089001026 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 879089001027 dimer interface [polypeptide binding]; other site 879089001028 FMN binding site [chemical binding]; other site 879089001029 NADPH bind site [chemical binding]; other site 879089001030 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 879089001031 HTH domain; Region: HTH_11; pfam08279 879089001032 Mga helix-turn-helix domain; Region: Mga; pfam05043 879089001033 PRD domain; Region: PRD; pfam00874 879089001034 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 879089001035 active site 879089001036 P-loop; other site 879089001037 phosphorylation site [posttranslational modification] 879089001038 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089001039 active site 879089001040 phosphorylation site [posttranslational modification] 879089001041 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 879089001042 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 879089001043 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 879089001044 active site 879089001045 P-loop; other site 879089001046 phosphorylation site [posttranslational modification] 879089001047 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 879089001048 beta-galactosidase; Region: BGL; TIGR03356 879089001049 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 879089001050 methionine cluster; other site 879089001051 active site 879089001052 phosphorylation site [posttranslational modification] 879089001053 metal binding site [ion binding]; metal-binding site 879089001054 AAA domain; Region: AAA_11; pfam13086 879089001055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 879089001056 ATP binding site [chemical binding]; other site 879089001057 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 879089001058 AAA domain; Region: AAA_30; pfam13604 879089001059 AAA domain; Region: AAA_12; pfam13087 879089001060 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 879089001061 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 879089001062 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 879089001063 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 879089001064 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 879089001065 catalytic residue [active] 879089001066 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 879089001067 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 879089001068 nucleophilic elbow; other site 879089001069 catalytic triad; other site 879089001070 Uncharacterized conserved protein [Function unknown]; Region: COG1479 879089001071 Protein of unknown function DUF262; Region: DUF262; pfam03235 879089001072 Protein of unknown function DUF262; Region: DUF262; pfam03235 879089001073 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 879089001074 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 879089001075 putative active site [active] 879089001076 YdjC motif; other site 879089001077 Mg binding site [ion binding]; other site 879089001078 putative homodimer interface [polypeptide binding]; other site 879089001079 Putative transcription activator [Transcription]; Region: TenA; COG0819 879089001080 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 879089001081 substrate binding site [chemical binding]; other site 879089001082 multimerization interface [polypeptide binding]; other site 879089001083 ATP binding site [chemical binding]; other site 879089001084 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 879089001085 dimer interface [polypeptide binding]; other site 879089001086 substrate binding site [chemical binding]; other site 879089001087 ATP binding site [chemical binding]; other site 879089001088 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 879089001089 thiamine phosphate binding site [chemical binding]; other site 879089001090 active site 879089001091 pyrophosphate binding site [ion binding]; other site 879089001092 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 879089001093 beta-galactosidase; Region: BGL; TIGR03356 879089001094 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089001095 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 879089001096 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 879089001097 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 879089001098 putative catalytic site [active] 879089001099 putative metal binding site [ion binding]; other site 879089001100 putative phosphate binding site [ion binding]; other site 879089001101 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089001102 non-specific DNA binding site [nucleotide binding]; other site 879089001103 salt bridge; other site 879089001104 sequence-specific DNA binding site [nucleotide binding]; other site 879089001105 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 879089001106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089001107 non-specific DNA binding site [nucleotide binding]; other site 879089001108 salt bridge; other site 879089001109 sequence-specific DNA binding site [nucleotide binding]; other site 879089001110 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 879089001111 Leucine rich repeat; Region: LRR_8; pfam13855 879089001112 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001113 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001114 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001115 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001116 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001117 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001118 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001119 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001120 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001121 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001122 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001123 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001124 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001125 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001126 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001127 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001128 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089001129 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 879089001130 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 879089001131 LRR adjacent; Region: LRR_adjacent; pfam08191 879089001132 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089001133 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 879089001134 Leucine-rich repeats; other site 879089001135 Substrate binding site [chemical binding]; other site 879089001136 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001137 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001138 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001139 Leucine rich repeat; Region: LRR_8; pfam13855 879089001140 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 879089001141 Leucine-rich repeats; other site 879089001142 Leucine rich repeat; Region: LRR_8; pfam13855 879089001143 Substrate binding site [chemical binding]; other site 879089001144 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001145 Leucine rich repeat; Region: LRR_8; pfam13855 879089001146 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001147 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001148 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001149 LRR adjacent; Region: LRR_adjacent; pfam08191 879089001150 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001151 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001152 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001153 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 879089001154 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 879089001155 LXG domain of WXG superfamily; Region: LXG; pfam04740 879089001156 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 879089001157 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 879089001158 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 879089001159 TPP-binding site [chemical binding]; other site 879089001160 dimer interface [polypeptide binding]; other site 879089001161 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 879089001162 PYR/PP interface [polypeptide binding]; other site 879089001163 dimer interface [polypeptide binding]; other site 879089001164 TPP binding site [chemical binding]; other site 879089001165 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 879089001166 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 879089001167 active site 879089001168 intersubunit interactions; other site 879089001169 catalytic residue [active] 879089001170 short chain dehydrogenase; Provisional; Region: PRK06841 879089001171 classical (c) SDRs; Region: SDR_c; cd05233 879089001172 NAD(P) binding site [chemical binding]; other site 879089001173 active site 879089001174 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 879089001175 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 879089001176 substrate binding site [chemical binding]; other site 879089001177 dimer interface [polypeptide binding]; other site 879089001178 catalytic triad [active] 879089001179 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 879089001180 DAK2 domain; Region: Dak2; cl03685 879089001181 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 879089001182 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 879089001183 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 879089001184 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 879089001185 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 879089001186 putative DNA binding site [nucleotide binding]; other site 879089001187 putative Zn2+ binding site [ion binding]; other site 879089001188 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 879089001189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089001190 Coenzyme A binding pocket [chemical binding]; other site 879089001191 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 879089001192 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 879089001193 LRR adjacent; Region: LRR_adjacent; pfam08191 879089001194 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089001195 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089001196 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 879089001197 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 879089001198 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 879089001199 acyl-activating enzyme (AAE) consensus motif; other site 879089001200 acyl-activating enzyme (AAE) consensus motif; other site 879089001201 AMP binding site [chemical binding]; other site 879089001202 active site 879089001203 CoA binding site [chemical binding]; other site 879089001204 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 879089001205 L-aspartate oxidase; Provisional; Region: PRK06175 879089001206 putative oxidoreductase; Provisional; Region: PRK10206 879089001207 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 879089001208 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 879089001209 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089001210 active site 879089001211 phosphorylation site [posttranslational modification] 879089001212 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 879089001213 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 879089001214 active site 879089001215 P-loop; other site 879089001216 phosphorylation site [posttranslational modification] 879089001217 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 879089001218 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 879089001219 intersubunit interface [polypeptide binding]; other site 879089001220 active site 879089001221 zinc binding site [ion binding]; other site 879089001222 Na+ binding site [ion binding]; other site 879089001223 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 879089001224 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 879089001225 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 879089001226 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 879089001227 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 879089001228 Peptidase E [Amino acid transport and metabolism]; Region: PepE; COG3340 879089001229 conserved cys residue [active] 879089001230 Predicted transcriptional regulator [Transcription]; Region: COG2378 879089001231 HTH domain; Region: HTH_11; pfam08279 879089001232 WYL domain; Region: WYL; pfam13280 879089001233 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 879089001234 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 879089001235 Imelysin; Region: Peptidase_M75; pfam09375 879089001236 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 879089001237 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 879089001238 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 879089001239 nudix motif; other site 879089001240 hypothetical protein; Provisional; Region: PRK12378 879089001241 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 879089001242 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 879089001243 PhnA protein; Region: PhnA; pfam03831 879089001244 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 879089001245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089001246 DNA-binding site [nucleotide binding]; DNA binding site 879089001247 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 879089001248 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 879089001249 beta-galactosidase; Region: BGL; TIGR03356 879089001250 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 879089001251 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 879089001252 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 879089001253 active site 879089001254 P-loop; other site 879089001255 phosphorylation site [posttranslational modification] 879089001256 Predicted transcriptional regulator [Transcription]; Region: COG2378 879089001257 HTH domain; Region: HTH_11; pfam08279 879089001258 WYL domain; Region: WYL; pfam13280 879089001259 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 879089001260 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 879089001261 active site 879089001262 NTP binding site [chemical binding]; other site 879089001263 nucleic acid binding site [nucleotide binding]; other site 879089001264 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 879089001265 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 879089001266 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 879089001267 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 879089001268 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 879089001269 tetrameric interface [polypeptide binding]; other site 879089001270 NAD binding site [chemical binding]; other site 879089001271 catalytic residues [active] 879089001272 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 879089001273 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 879089001274 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 879089001275 substrate binding site [chemical binding]; other site 879089001276 ATP binding site [chemical binding]; other site 879089001277 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 879089001278 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 879089001279 PYR/PP interface [polypeptide binding]; other site 879089001280 dimer interface [polypeptide binding]; other site 879089001281 TPP binding site [chemical binding]; other site 879089001282 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 879089001283 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 879089001284 TPP-binding site; other site 879089001285 Uncharacterized conserved protein [Function unknown]; Region: COG5646 879089001286 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 879089001287 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 879089001288 ligand binding site [chemical binding]; other site 879089001289 active site 879089001290 UGI interface [polypeptide binding]; other site 879089001291 catalytic site [active] 879089001292 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 879089001293 hypothetical protein; Provisional; Region: PRK13665 879089001294 Bacterial SH3 domain; Region: SH3_3; cl17532 879089001295 NlpC/P60 family; Region: NLPC_P60; pfam00877 879089001296 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 879089001297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089001298 Coenzyme A binding pocket [chemical binding]; other site 879089001299 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 879089001300 pyrroline-5-carboxylate reductase; Region: PLN02688 879089001301 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089001302 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089001303 Transcriptional regulators [Transcription]; Region: GntR; COG1802 879089001304 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089001305 DNA-binding site [nucleotide binding]; DNA binding site 879089001306 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 879089001307 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 879089001308 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 879089001309 Walker A/P-loop; other site 879089001310 ATP binding site [chemical binding]; other site 879089001311 Q-loop/lid; other site 879089001312 ABC transporter signature motif; other site 879089001313 Walker B; other site 879089001314 D-loop; other site 879089001315 H-loop/switch region; other site 879089001316 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 879089001317 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 879089001318 FtsX-like permease family; Region: FtsX; pfam02687 879089001319 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 879089001320 putative hydrophobic ligand binding site [chemical binding]; other site 879089001321 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089001322 active site 879089001323 phosphorylation site [posttranslational modification] 879089001324 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 879089001325 active site 879089001326 P-loop; other site 879089001327 phosphorylation site [posttranslational modification] 879089001328 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 879089001329 alpha-mannosidase; Provisional; Region: PRK09819 879089001330 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 879089001331 active site 879089001332 metal binding site [ion binding]; metal-binding site 879089001333 catalytic site [active] 879089001334 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 879089001335 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 879089001336 HTH domain; Region: HTH_11; pfam08279 879089001337 Mga helix-turn-helix domain; Region: Mga; pfam05043 879089001338 PRD domain; Region: PRD; pfam00874 879089001339 PRD domain; Region: PRD; pfam00874 879089001340 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 879089001341 active site 879089001342 P-loop; other site 879089001343 phosphorylation site [posttranslational modification] 879089001344 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089001345 active site 879089001346 phosphorylation site [posttranslational modification] 879089001347 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 879089001348 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 879089001349 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 879089001350 putative metal binding site [ion binding]; other site 879089001351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 879089001352 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 879089001353 trimer interface [polypeptide binding]; other site 879089001354 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 879089001355 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001356 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 879089001357 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001358 Leucine-rich repeats; other site 879089001359 Substrate binding site [chemical binding]; other site 879089001360 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001361 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001362 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001363 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001364 LRR adjacent; Region: LRR_adjacent; pfam08191 879089001365 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089001366 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089001367 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089001368 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089001369 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089001370 phosphoenolpyruvate synthase; Validated; Region: PRK06241 879089001371 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 879089001372 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 879089001373 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 879089001374 ZIP Zinc transporter; Region: Zip; pfam02535 879089001375 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 879089001376 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 879089001377 NodB motif; other site 879089001378 active site 879089001379 catalytic site [active] 879089001380 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089001381 non-specific DNA binding site [nucleotide binding]; other site 879089001382 salt bridge; other site 879089001383 sequence-specific DNA binding site [nucleotide binding]; other site 879089001384 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 879089001385 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 879089001386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089001387 active site 879089001388 motif I; other site 879089001389 motif II; other site 879089001390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089001391 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 879089001392 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 879089001393 HTH domain; Region: HTH_11; pfam08279 879089001394 PRD domain; Region: PRD; pfam00874 879089001395 PRD domain; Region: PRD; pfam00874 879089001396 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 879089001397 active site 879089001398 P-loop; other site 879089001399 phosphorylation site [posttranslational modification] 879089001400 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089001401 active site 879089001402 phosphorylation site [posttranslational modification] 879089001403 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089001404 active site 879089001405 phosphorylation site [posttranslational modification] 879089001406 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 879089001407 active site 879089001408 P-loop; other site 879089001409 phosphorylation site [posttranslational modification] 879089001410 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 879089001411 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 879089001412 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 879089001413 active site 879089001414 metal binding site [ion binding]; metal-binding site 879089001415 catalytic site [active] 879089001416 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 879089001417 Transcriptional regulator [Transcription]; Region: LysR; COG0583 879089001418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 879089001419 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 879089001420 dimerization interface [polypeptide binding]; other site 879089001421 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 879089001422 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 879089001423 active site 879089001424 substrate binding site [chemical binding]; other site 879089001425 trimer interface [polypeptide binding]; other site 879089001426 CoA binding site [chemical binding]; other site 879089001427 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 879089001428 classical (c) SDRs; Region: SDR_c; cd05233 879089001429 NAD(P) binding site [chemical binding]; other site 879089001430 active site 879089001431 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 879089001432 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001433 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 879089001434 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001435 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001436 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001437 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001438 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001439 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001440 LRR adjacent; Region: LRR_adjacent; pfam08191 879089001441 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089001442 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089001443 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089001444 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 879089001445 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 879089001446 Leucine rich repeat; Region: LRR_8; pfam13855 879089001447 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 879089001448 Leucine rich repeat; Region: LRR_8; pfam13855 879089001449 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001450 LRR adjacent; Region: LRR_adjacent; pfam08191 879089001451 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089001452 SH3-like domain; Region: SH3_8; pfam13457 879089001453 Predicted transcriptional regulator [Transcription]; Region: COG1959 879089001454 Transcriptional regulator; Region: Rrf2; pfam02082 879089001455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 879089001456 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 879089001457 NAD(P) binding site [chemical binding]; other site 879089001458 active site 879089001459 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 879089001460 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 879089001461 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 879089001462 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 879089001463 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 879089001464 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 879089001465 Transcriptional regulator [Transcription]; Region: LytR; COG1316 879089001466 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 879089001467 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 879089001468 Predicted membrane protein [Function unknown]; Region: COG3619 879089001469 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 879089001470 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 879089001471 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 879089001472 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 879089001473 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 879089001474 Protein of unknown function DUF58; Region: DUF58; pfam01882 879089001475 MoxR-like ATPases [General function prediction only]; Region: COG0714 879089001476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089001477 Walker A motif; other site 879089001478 ATP binding site [chemical binding]; other site 879089001479 Walker B motif; other site 879089001480 arginine finger; other site 879089001481 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 879089001482 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 879089001483 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 879089001484 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 879089001485 Na binding site [ion binding]; other site 879089001486 Uncharacterized conserved protein [Function unknown]; Region: COG3535 879089001487 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 879089001488 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 879089001489 nucleotide binding site [chemical binding]; other site 879089001490 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 879089001491 Mga helix-turn-helix domain; Region: Mga; pfam05043 879089001492 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001493 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 879089001494 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001495 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001496 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001497 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001498 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 879089001499 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001500 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001501 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001502 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001503 Leucine rich repeat; Region: LRR_8; pfam13855 879089001504 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089001505 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 879089001506 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001507 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001508 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 879089001509 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001510 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001511 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001512 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 879089001513 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001514 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001515 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089001516 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089001517 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 879089001518 Zn2+ binding site [ion binding]; other site 879089001519 Mg2+ binding site [ion binding]; other site 879089001520 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 879089001521 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 879089001522 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 879089001523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 879089001524 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 879089001525 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 879089001526 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 879089001527 FeS/SAM binding site; other site 879089001528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 879089001529 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 879089001530 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 879089001531 putative active site [active] 879089001532 putative NTP binding site [chemical binding]; other site 879089001533 putative nucleic acid binding site [nucleotide binding]; other site 879089001534 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 879089001535 putative FMN binding site [chemical binding]; other site 879089001536 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 879089001537 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 879089001538 nudix motif; other site 879089001539 Transcriptional regulator [Transcription]; Region: LysR; COG0583 879089001540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 879089001541 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 879089001542 putative dimerization interface [polypeptide binding]; other site 879089001543 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 879089001544 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 879089001545 active site 879089001546 FMN binding site [chemical binding]; other site 879089001547 substrate binding site [chemical binding]; other site 879089001548 putative catalytic residue [active] 879089001549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 879089001550 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 879089001551 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 879089001552 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 879089001553 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 879089001554 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 879089001555 shikimate binding site; other site 879089001556 NAD(P) binding site [chemical binding]; other site 879089001557 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 879089001558 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 879089001559 active site 879089001560 catalytic residue [active] 879089001561 dimer interface [polypeptide binding]; other site 879089001562 Transcriptional regulator [Transcription]; Region: LysR; COG0583 879089001563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 879089001564 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 879089001565 dimerization interface [polypeptide binding]; other site 879089001566 substrate binding pocket [chemical binding]; other site 879089001567 Predicted acyl esterases [General function prediction only]; Region: COG2936 879089001568 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 879089001569 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 879089001570 active site 879089001571 catalytic triad [active] 879089001572 oxyanion hole [active] 879089001573 EamA-like transporter family; Region: EamA; pfam00892 879089001574 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 879089001575 EamA-like transporter family; Region: EamA; pfam00892 879089001576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 879089001577 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 879089001578 active site 879089001579 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 879089001580 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 879089001581 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 879089001582 substrate binding site [chemical binding]; other site 879089001583 hexamer interface [polypeptide binding]; other site 879089001584 metal binding site [ion binding]; metal-binding site 879089001585 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 879089001586 catalytic residue [active] 879089001587 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 879089001588 PRD domain; Region: PRD; pfam00874 879089001589 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 879089001590 active site 879089001591 P-loop; other site 879089001592 phosphorylation site [posttranslational modification] 879089001593 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089001594 active site 879089001595 phosphorylation site [posttranslational modification] 879089001596 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 879089001597 putative active site [active] 879089001598 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089001599 active site 879089001600 phosphorylation site [posttranslational modification] 879089001601 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 879089001602 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 879089001603 substrate binding site [chemical binding]; other site 879089001604 hexamer interface [polypeptide binding]; other site 879089001605 metal binding site [ion binding]; metal-binding site 879089001606 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 879089001607 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 879089001608 putative NAD(P) binding site [chemical binding]; other site 879089001609 catalytic Zn binding site [ion binding]; other site 879089001610 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 879089001611 active site 879089001612 P-loop; other site 879089001613 phosphorylation site [posttranslational modification] 879089001614 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 879089001615 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 879089001616 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 879089001617 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 879089001618 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 879089001619 active site 879089001620 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 879089001621 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 879089001622 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 879089001623 catalytic triad [active] 879089001624 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 879089001625 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 879089001626 MarR family; Region: MarR_2; pfam12802 879089001627 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001628 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089001629 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 879089001630 Ligand Binding Site [chemical binding]; other site 879089001631 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 879089001632 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 879089001633 putative active site [active] 879089001634 putative metal binding site [ion binding]; other site 879089001635 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 879089001636 catalytic core [active] 879089001637 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 879089001638 Predicted membrane protein [Function unknown]; Region: COG3759 879089001639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089001640 Major Facilitator Superfamily; Region: MFS_1; pfam07690 879089001641 putative substrate translocation pore; other site 879089001642 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 879089001643 non-specific DNA interactions [nucleotide binding]; other site 879089001644 DNA binding site [nucleotide binding] 879089001645 sequence specific DNA binding site [nucleotide binding]; other site 879089001646 putative cAMP binding site [chemical binding]; other site 879089001647 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 879089001648 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 879089001649 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 879089001650 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 879089001651 NAD binding site [chemical binding]; other site 879089001652 sugar binding site [chemical binding]; other site 879089001653 divalent metal binding site [ion binding]; other site 879089001654 tetramer (dimer of dimers) interface [polypeptide binding]; other site 879089001655 dimer interface [polypeptide binding]; other site 879089001656 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 879089001657 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 879089001658 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 879089001659 putative active site [active] 879089001660 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 879089001661 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 879089001662 Sulfate transporter family; Region: Sulfate_transp; pfam00916 879089001663 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 879089001664 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 879089001665 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 879089001666 DNA binding residues [nucleotide binding] 879089001667 dimer interface [polypeptide binding]; other site 879089001668 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 879089001669 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 879089001670 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 879089001671 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 879089001672 DXD motif; other site 879089001673 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 879089001674 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 879089001675 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 879089001676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089001677 S-adenosylmethionine binding site [chemical binding]; other site 879089001678 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 879089001679 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 879089001680 Transcriptional regulators [Transcription]; Region: PurR; COG1609 879089001681 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 879089001682 DNA binding site [nucleotide binding] 879089001683 domain linker motif; other site 879089001684 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 879089001685 putative dimerization interface [polypeptide binding]; other site 879089001686 putative ligand binding site [chemical binding]; other site 879089001687 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 879089001688 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 879089001689 NAD binding site [chemical binding]; other site 879089001690 sugar binding site [chemical binding]; other site 879089001691 divalent metal binding site [ion binding]; other site 879089001692 tetramer (dimer of dimers) interface [polypeptide binding]; other site 879089001693 dimer interface [polypeptide binding]; other site 879089001694 allantoate amidohydrolase; Reviewed; Region: PRK09290 879089001695 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 879089001696 active site 879089001697 metal binding site [ion binding]; metal-binding site 879089001698 dimer interface [polypeptide binding]; other site 879089001699 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 879089001700 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 879089001701 metal binding site [ion binding]; metal-binding site 879089001702 putative dimer interface [polypeptide binding]; other site 879089001703 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 879089001704 Beta-lactamase; Region: Beta-lactamase; pfam00144 879089001705 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 879089001706 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 879089001707 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 879089001708 intersubunit interface [polypeptide binding]; other site 879089001709 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 879089001710 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 879089001711 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 879089001712 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 879089001713 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 879089001714 Glucitol operon activator protein (GutM); Region: GutM; cl01890 879089001715 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 879089001716 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 879089001717 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 879089001718 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 879089001719 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 879089001720 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089001721 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 879089001722 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001723 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001724 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001725 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089001726 WxL domain surface cell wall-binding; Region: WxL; pfam13731 879089001727 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 879089001728 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 879089001729 FOG: CBS domain [General function prediction only]; Region: COG0517 879089001730 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 879089001731 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 879089001732 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 879089001733 dimer interface [polypeptide binding]; other site 879089001734 active site 879089001735 metal binding site [ion binding]; metal-binding site 879089001736 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 879089001737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089001738 putative substrate translocation pore; other site 879089001739 POT family; Region: PTR2; pfam00854 879089001740 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 879089001741 catalytic core [active] 879089001742 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 879089001743 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 879089001744 catalytic core [active] 879089001745 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 879089001746 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 879089001747 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 879089001748 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 879089001749 Cl binding site [ion binding]; other site 879089001750 oligomer interface [polypeptide binding]; other site 879089001751 glutamate dehydrogenase; Provisional; Region: PRK09414 879089001752 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 879089001753 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 879089001754 NAD(P) binding site [chemical binding]; other site 879089001755 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 879089001756 metal binding site [ion binding]; metal-binding site 879089001757 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 879089001758 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 879089001759 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 879089001760 substrate binding site [chemical binding]; other site 879089001761 glutamase interaction surface [polypeptide binding]; other site 879089001762 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 879089001763 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 879089001764 catalytic residues [active] 879089001765 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 879089001766 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 879089001767 putative active site [active] 879089001768 oxyanion strand; other site 879089001769 catalytic triad [active] 879089001770 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 879089001771 putative active site pocket [active] 879089001772 4-fold oligomerization interface [polypeptide binding]; other site 879089001773 metal binding residues [ion binding]; metal-binding site 879089001774 3-fold/trimer interface [polypeptide binding]; other site 879089001775 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 879089001776 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 879089001777 NAD binding site [chemical binding]; other site 879089001778 dimerization interface [polypeptide binding]; other site 879089001779 product binding site; other site 879089001780 substrate binding site [chemical binding]; other site 879089001781 zinc binding site [ion binding]; other site 879089001782 catalytic residues [active] 879089001783 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 879089001784 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 879089001785 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 879089001786 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 879089001787 dimer interface [polypeptide binding]; other site 879089001788 motif 1; other site 879089001789 active site 879089001790 motif 2; other site 879089001791 motif 3; other site 879089001792 histidinol-phosphatase; Reviewed; Region: PRK08123 879089001793 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 879089001794 active site 879089001795 dimer interface [polypeptide binding]; other site 879089001796 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 879089001797 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 879089001798 DNA binding site [nucleotide binding] 879089001799 active site 879089001800 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 879089001801 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 879089001802 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 879089001803 beta-galactosidase; Region: BGL; TIGR03356 879089001804 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 879089001805 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089001806 DNA-binding site [nucleotide binding]; DNA binding site 879089001807 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 879089001808 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001809 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089001810 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 879089001811 Uncharacterized conserved protein [Function unknown]; Region: COG2966 879089001812 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 879089001813 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 879089001814 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 879089001815 Predicted esterase [General function prediction only]; Region: COG0400 879089001816 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 879089001817 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 879089001818 putative RNA binding site [nucleotide binding]; other site 879089001819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089001820 S-adenosylmethionine binding site [chemical binding]; other site 879089001821 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 879089001822 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 879089001823 Bacterial SH3 domain; Region: SH3_3; pfam08239 879089001824 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 879089001825 NlpC/P60 family; Region: NLPC_P60; pfam00877 879089001826 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 879089001827 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 879089001828 ATP binding site [chemical binding]; other site 879089001829 putative Mg++ binding site [ion binding]; other site 879089001830 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 879089001831 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 879089001832 nucleotide binding region [chemical binding]; other site 879089001833 ATP-binding site [chemical binding]; other site 879089001834 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 879089001835 Domain of unknown function DUF20; Region: UPF0118; pfam01594 879089001836 WxL domain surface cell wall-binding; Region: WxL; pfam13731 879089001837 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 879089001838 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 879089001839 UreD urease accessory protein; Region: UreD; cl00530 879089001840 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 879089001841 DNA photolyase; Region: DNA_photolyase; pfam00875 879089001842 Predicted membrane protein [Function unknown]; Region: COG4852 879089001843 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 879089001844 DAK2 domain; Region: Dak2; pfam02734 879089001845 EDD domain protein, DegV family; Region: DegV; TIGR00762 879089001846 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 879089001847 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 879089001848 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 879089001849 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 879089001850 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 879089001851 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 879089001852 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 879089001853 homodimer interface [polypeptide binding]; other site 879089001854 substrate-cofactor binding pocket; other site 879089001855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089001856 catalytic residue [active] 879089001857 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 879089001858 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089001859 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 879089001860 ligand binding site [chemical binding]; other site 879089001861 flexible hinge region; other site 879089001862 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 879089001863 BioY family; Region: BioY; pfam02632 879089001864 Predicted transcriptional regulators [Transcription]; Region: COG1695 879089001865 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 879089001866 Predicted membrane protein [Function unknown]; Region: COG4709 879089001867 Uncharacterized conserved protein [Function unknown]; Region: COG3595 879089001868 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 879089001869 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 879089001870 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 879089001871 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 879089001872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089001873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 879089001874 Coenzyme A binding pocket [chemical binding]; other site 879089001875 Tic20-like protein; Region: Tic20; pfam09685 879089001876 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 879089001877 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 879089001878 Transcriptional regulators [Transcription]; Region: MarR; COG1846 879089001879 MarR family; Region: MarR_2; pfam12802 879089001880 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 879089001881 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 879089001882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089001883 Walker A/P-loop; other site 879089001884 ATP binding site [chemical binding]; other site 879089001885 Q-loop/lid; other site 879089001886 ABC transporter signature motif; other site 879089001887 Walker B; other site 879089001888 D-loop; other site 879089001889 H-loop/switch region; other site 879089001890 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 879089001891 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 879089001892 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 879089001893 Walker A/P-loop; other site 879089001894 ATP binding site [chemical binding]; other site 879089001895 Q-loop/lid; other site 879089001896 ABC transporter signature motif; other site 879089001897 Walker B; other site 879089001898 D-loop; other site 879089001899 H-loop/switch region; other site 879089001900 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 879089001901 active site residue [active] 879089001902 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089001903 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 879089001904 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 879089001905 Transcriptional regulators [Transcription]; Region: MarR; COG1846 879089001906 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 879089001907 putative DNA binding site [nucleotide binding]; other site 879089001908 putative Zn2+ binding site [ion binding]; other site 879089001909 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 879089001910 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 879089001911 putative NAD(P) binding site [chemical binding]; other site 879089001912 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 879089001913 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 879089001914 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 879089001915 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 879089001916 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 879089001917 putative active site [active] 879089001918 catalytic site [active] 879089001919 putative metal binding site [ion binding]; other site 879089001920 Catalytic domain of Protein Kinases; Region: PKc; cd00180 879089001921 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 879089001922 active site 879089001923 ATP binding site [chemical binding]; other site 879089001924 substrate binding site [chemical binding]; other site 879089001925 activation loop (A-loop); other site 879089001926 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 879089001927 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 879089001928 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 879089001929 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 879089001930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089001931 Coenzyme A binding pocket [chemical binding]; other site 879089001932 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 879089001933 active site 879089001934 catalytic triad [active] 879089001935 oxyanion hole [active] 879089001936 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 879089001937 domain interaction interfaces [polypeptide binding]; other site 879089001938 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 879089001939 domain interaction interfaces [polypeptide binding]; other site 879089001940 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 879089001941 domain interaction interfaces [polypeptide binding]; other site 879089001942 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 879089001943 domain interaction interfaces [polypeptide binding]; other site 879089001944 Isochorismatase family; Region: Isochorismatase; pfam00857 879089001945 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 879089001946 catalytic triad [active] 879089001947 conserved cis-peptide bond; other site 879089001948 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 879089001949 PRD domain; Region: PRD; pfam00874 879089001950 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 879089001951 active site 879089001952 P-loop; other site 879089001953 phosphorylation site [posttranslational modification] 879089001954 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089001955 active site 879089001956 phosphorylation site [posttranslational modification] 879089001957 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089001958 active site 879089001959 phosphorylation site [posttranslational modification] 879089001960 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 879089001961 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 879089001962 active site 879089001963 P-loop; other site 879089001964 phosphorylation site [posttranslational modification] 879089001965 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 879089001966 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 879089001967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089001968 motif II; other site 879089001969 Predicted transcriptional regulator [Transcription]; Region: COG1959 879089001970 Transcriptional regulator; Region: Rrf2; pfam02082 879089001971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089001972 S-adenosylmethionine binding site [chemical binding]; other site 879089001973 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 879089001974 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 879089001975 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 879089001976 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 879089001977 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 879089001978 active site 879089001979 catalytic tetrad [active] 879089001980 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 879089001981 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 879089001982 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089001983 motif II; other site 879089001984 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 879089001985 catalytic residue [active] 879089001986 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 879089001987 Sulfatase; Region: Sulfatase; pfam00884 879089001988 amino acid transporter; Region: 2A0306; TIGR00909 879089001989 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 879089001990 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 879089001991 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 879089001992 putative metal binding site [ion binding]; other site 879089001993 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 879089001994 active site 879089001995 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 879089001996 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 879089001997 Cl binding site [ion binding]; other site 879089001998 oligomer interface [polypeptide binding]; other site 879089001999 Transcriptional regulators [Transcription]; Region: GntR; COG1802 879089002000 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089002001 DNA-binding site [nucleotide binding]; DNA binding site 879089002002 Predicted membrane protein [Function unknown]; Region: COG1511 879089002003 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 879089002004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089002005 Transcriptional regulators [Transcription]; Region: GntR; COG1802 879089002006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089002007 DNA-binding site [nucleotide binding]; DNA binding site 879089002008 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 879089002009 Predicted integral membrane protein [Function unknown]; Region: COG5523 879089002010 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 879089002011 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 879089002012 active site 879089002013 metal binding site [ion binding]; metal-binding site 879089002014 Predicted membrane protein [Function unknown]; Region: COG2322 879089002015 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 879089002016 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 879089002017 minor groove reading motif; other site 879089002018 helix-hairpin-helix signature motif; other site 879089002019 substrate binding pocket [chemical binding]; other site 879089002020 active site 879089002021 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089002022 non-specific DNA binding site [nucleotide binding]; other site 879089002023 salt bridge; other site 879089002024 sequence-specific DNA binding site [nucleotide binding]; other site 879089002025 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 879089002026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 879089002027 Transposase; Region: HTH_Tnp_1; cl17663 879089002028 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089002029 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089002030 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089002031 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 879089002032 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 879089002033 dimer interface [polypeptide binding]; other site 879089002034 substrate binding site [chemical binding]; other site 879089002035 ATP binding site [chemical binding]; other site 879089002036 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 879089002037 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089002038 active site 879089002039 motif I; other site 879089002040 motif II; other site 879089002041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089002042 maltose O-acetyltransferase; Provisional; Region: PRK10092 879089002043 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 879089002044 active site 879089002045 substrate binding site [chemical binding]; other site 879089002046 trimer interface [polypeptide binding]; other site 879089002047 CoA binding site [chemical binding]; other site 879089002048 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 879089002049 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 879089002050 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 879089002051 Walker A/P-loop; other site 879089002052 ATP binding site [chemical binding]; other site 879089002053 Q-loop/lid; other site 879089002054 ABC transporter signature motif; other site 879089002055 Walker B; other site 879089002056 D-loop; other site 879089002057 H-loop/switch region; other site 879089002058 inner membrane transport permease; Provisional; Region: PRK15066 879089002059 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 879089002060 oxidoreductase; Provisional; Region: PRK07985 879089002061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 879089002062 NAD(P) binding site [chemical binding]; other site 879089002063 active site 879089002064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 879089002065 Predicted membrane protein [Function unknown]; Region: COG3152 879089002066 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 879089002067 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 879089002068 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 879089002069 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 879089002070 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 879089002071 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 879089002072 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 879089002073 FHIPEP family; Region: FHIPEP; pfam00771 879089002074 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 879089002075 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 879089002076 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 879089002077 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 879089002078 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 879089002079 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 879089002080 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 879089002081 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 879089002082 flagellar motor protein MotA; Validated; Region: PRK08124 879089002083 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 879089002084 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 879089002085 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 879089002086 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 879089002087 ligand binding site [chemical binding]; other site 879089002088 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 879089002089 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 879089002090 putative metal binding site; other site 879089002091 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 879089002092 binding surface 879089002093 TPR motif; other site 879089002094 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 879089002095 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 879089002096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089002097 active site 879089002098 phosphorylation site [posttranslational modification] 879089002099 intermolecular recognition site; other site 879089002100 dimerization interface [polypeptide binding]; other site 879089002101 flagellin; Provisional; Region: PRK12805 879089002102 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 879089002103 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 879089002104 Response regulator receiver domain; Region: Response_reg; pfam00072 879089002105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089002106 active site 879089002107 phosphorylation site [posttranslational modification] 879089002108 intermolecular recognition site; other site 879089002109 dimerization interface [polypeptide binding]; other site 879089002110 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 879089002111 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 879089002112 putative binding surface; other site 879089002113 active site 879089002114 P2 response regulator binding domain; Region: P2; pfam07194 879089002115 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 879089002116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089002117 ATP binding site [chemical binding]; other site 879089002118 Mg2+ binding site [ion binding]; other site 879089002119 G-X-G motif; other site 879089002120 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 879089002121 flagellar motor switch protein; Validated; Region: PRK06788 879089002122 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 879089002123 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 879089002124 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 879089002125 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 879089002126 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 879089002127 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 879089002128 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 879089002129 flagellar motor switch protein; Validated; Region: PRK06789 879089002130 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 879089002131 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 879089002132 flagellar motor switch protein; Reviewed; Region: PRK06782 879089002133 CheC-like family; Region: CheC; pfam04509 879089002134 CheC-like family; Region: CheC; pfam04509 879089002135 Chemotaxis phosphatase CheX; Region: CheX; cl15816 879089002136 CheC-like family; Region: CheC; pfam04509 879089002137 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 879089002138 Protein of unknown function (DUF327); Region: DUF327; pfam03885 879089002139 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 879089002140 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 879089002141 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 879089002142 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 879089002143 flagellar capping protein; Validated; Region: fliD; PRK06798 879089002144 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 879089002145 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 879089002146 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 879089002147 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 879089002148 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 879089002149 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 879089002150 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 879089002151 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 879089002152 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 879089002153 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 879089002154 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 879089002155 FliG C-terminal domain; Region: FliG_C; pfam01706 879089002156 flagellar assembly protein H; Validated; Region: fliH; PRK06800 879089002157 Flagellar assembly protein FliH; Region: FliH; pfam02108 879089002158 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 879089002159 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 879089002160 Walker A motif; other site 879089002161 ATP binding site [chemical binding]; other site 879089002162 Walker B motif; other site 879089002163 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 879089002164 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 879089002165 N-acetyl-D-glucosamine binding site [chemical binding]; other site 879089002166 catalytic residue [active] 879089002167 Predicted transcriptional regulators [Transcription]; Region: COG1695 879089002168 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 879089002169 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 879089002170 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 879089002171 pyruvate oxidase; Provisional; Region: PRK08611 879089002172 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 879089002173 PYR/PP interface [polypeptide binding]; other site 879089002174 dimer interface [polypeptide binding]; other site 879089002175 tetramer interface [polypeptide binding]; other site 879089002176 TPP binding site [chemical binding]; other site 879089002177 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 879089002178 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 879089002179 TPP-binding site [chemical binding]; other site 879089002180 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 879089002181 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 879089002182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 879089002183 dimerization interface [polypeptide binding]; other site 879089002184 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 879089002185 dimer interface [polypeptide binding]; other site 879089002186 putative CheW interface [polypeptide binding]; other site 879089002187 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 879089002188 putative active site [active] 879089002189 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 879089002190 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 879089002191 glutaminase active site [active] 879089002192 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 879089002193 dimer interface [polypeptide binding]; other site 879089002194 active site 879089002195 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 879089002196 dimer interface [polypeptide binding]; other site 879089002197 active site 879089002198 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 879089002199 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 879089002200 active site 879089002201 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 879089002202 GIY-YIG motif/motif A; other site 879089002203 Leucine rich repeat; Region: LRR_8; pfam13855 879089002204 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089002205 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089002206 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089002207 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 879089002208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089002209 non-specific DNA binding site [nucleotide binding]; other site 879089002210 salt bridge; other site 879089002211 sequence-specific DNA binding site [nucleotide binding]; other site 879089002212 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089002213 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 879089002214 ligand binding site [chemical binding]; other site 879089002215 flexible hinge region; other site 879089002216 Predicted transcriptional regulators [Transcription]; Region: COG1725 879089002217 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089002218 DNA-binding site [nucleotide binding]; DNA binding site 879089002219 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 879089002220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089002221 Walker A/P-loop; other site 879089002222 ATP binding site [chemical binding]; other site 879089002223 Q-loop/lid; other site 879089002224 ABC transporter signature motif; other site 879089002225 Walker B; other site 879089002226 D-loop; other site 879089002227 H-loop/switch region; other site 879089002228 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 879089002229 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 879089002230 Walker A/P-loop; other site 879089002231 ATP binding site [chemical binding]; other site 879089002232 Q-loop/lid; other site 879089002233 ABC transporter signature motif; other site 879089002234 Walker B; other site 879089002235 D-loop; other site 879089002236 H-loop/switch region; other site 879089002237 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 879089002238 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 879089002239 FtsX-like permease family; Region: FtsX; pfam02687 879089002240 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 879089002241 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089002242 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 879089002243 ligand binding site [chemical binding]; other site 879089002244 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 879089002245 non-specific DNA interactions [nucleotide binding]; other site 879089002246 DNA binding site [nucleotide binding] 879089002247 sequence specific DNA binding site [nucleotide binding]; other site 879089002248 putative cAMP binding site [chemical binding]; other site 879089002249 SnoaL-like domain; Region: SnoaL_4; pfam13577 879089002250 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 879089002251 active site 879089002252 catalytic triad [active] 879089002253 oxyanion hole [active] 879089002254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089002255 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 879089002256 Walker A/P-loop; other site 879089002257 ATP binding site [chemical binding]; other site 879089002258 Q-loop/lid; other site 879089002259 ABC transporter signature motif; other site 879089002260 Walker B; other site 879089002261 D-loop; other site 879089002262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 879089002263 H-loop/switch region; other site 879089002264 active site 879089002265 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 879089002266 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 879089002267 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 879089002268 Zn binding site [ion binding]; other site 879089002269 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 879089002270 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 879089002271 Zn binding site [ion binding]; other site 879089002272 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 879089002273 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 879089002274 Zn binding site [ion binding]; other site 879089002275 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 879089002276 Zn binding site [ion binding]; other site 879089002277 Predicted esterase [General function prediction only]; Region: COG0400 879089002278 putative hydrolase; Provisional; Region: PRK11460 879089002279 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 879089002280 GTPases [General function prediction only]; Region: HflX; COG2262 879089002281 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 879089002282 HflX GTPase family; Region: HflX; cd01878 879089002283 G1 box; other site 879089002284 GTP/Mg2+ binding site [chemical binding]; other site 879089002285 Switch I region; other site 879089002286 G2 box; other site 879089002287 G3 box; other site 879089002288 Switch II region; other site 879089002289 G4 box; other site 879089002290 G5 box; other site 879089002291 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 879089002292 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 879089002293 putative active site [active] 879089002294 putative metal binding site [ion binding]; other site 879089002295 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 879089002296 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 879089002297 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 879089002298 Uncharacterized conserved protein [Function unknown]; Region: COG3538 879089002299 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 879089002300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 879089002301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089002302 putative PBP binding loops; other site 879089002303 ABC-ATPase subunit interface; other site 879089002304 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 879089002305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089002306 dimer interface [polypeptide binding]; other site 879089002307 conserved gate region; other site 879089002308 putative PBP binding loops; other site 879089002309 ABC-ATPase subunit interface; other site 879089002310 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 879089002311 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 879089002312 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 879089002313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089002314 DNA-binding site [nucleotide binding]; DNA binding site 879089002315 Transcriptional regulators [Transcription]; Region: PurR; COG1609 879089002316 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 879089002317 ligand binding site [chemical binding]; other site 879089002318 dimerization interface [polypeptide binding]; other site 879089002319 Transcriptional regulators [Transcription]; Region: GntR; COG1802 879089002320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089002321 DNA-binding site [nucleotide binding]; DNA binding site 879089002322 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 879089002323 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 879089002324 putative NADP binding site [chemical binding]; other site 879089002325 putative dimer interface [polypeptide binding]; other site 879089002326 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 879089002327 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 879089002328 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 879089002329 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 879089002330 nucleotide binding site [chemical binding]; other site 879089002331 Predicted membrane protein [Function unknown]; Region: COG4811 879089002332 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 879089002333 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 879089002334 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 879089002335 active site 879089002336 phosphorylation site [posttranslational modification] 879089002337 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 879089002338 active pocket/dimerization site; other site 879089002339 active site 879089002340 phosphorylation site [posttranslational modification] 879089002341 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 879089002342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089002343 Walker A motif; other site 879089002344 ATP binding site [chemical binding]; other site 879089002345 Walker B motif; other site 879089002346 arginine finger; other site 879089002347 Transcriptional antiterminator [Transcription]; Region: COG3933 879089002348 PRD domain; Region: PRD; pfam00874 879089002349 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 879089002350 active pocket/dimerization site; other site 879089002351 active site 879089002352 phosphorylation site [posttranslational modification] 879089002353 PRD domain; Region: PRD; pfam00874 879089002354 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 879089002355 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 879089002356 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 879089002357 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 879089002358 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 879089002359 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 879089002360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 879089002361 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 879089002362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 879089002363 Leucine rich repeat; Region: LRR_8; pfam13855 879089002364 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089002365 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089002366 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089002367 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089002368 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089002369 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089002370 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 879089002371 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 879089002372 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 879089002373 putative deacylase active site [active] 879089002374 Predicted amidohydrolase [General function prediction only]; Region: COG0388 879089002375 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 879089002376 active site 879089002377 catalytic triad [active] 879089002378 dimer interface [polypeptide binding]; other site 879089002379 Protein of unknown function (DUF554); Region: DUF554; pfam04474 879089002380 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 879089002381 NADH(P)-binding; Region: NAD_binding_10; pfam13460 879089002382 NAD binding site [chemical binding]; other site 879089002383 substrate binding site [chemical binding]; other site 879089002384 putative active site [active] 879089002385 Predicted permeases [General function prediction only]; Region: RarD; COG2962 879089002386 EamA-like transporter family; Region: EamA; pfam00892 879089002387 Uncharacterized conserved protein [Function unknown]; Region: COG2353 879089002388 Transcriptional regulators [Transcription]; Region: MarR; COG1846 879089002389 MarR family; Region: MarR_2; pfam12802 879089002390 lysine transporter; Provisional; Region: PRK10836 879089002391 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 879089002392 PAS domain; Region: PAS_9; pfam13426 879089002393 putative active site [active] 879089002394 heme pocket [chemical binding]; other site 879089002395 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 879089002396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 879089002397 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 879089002398 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 879089002399 synthetase active site [active] 879089002400 NTP binding site [chemical binding]; other site 879089002401 metal binding site [ion binding]; metal-binding site 879089002402 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 879089002403 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 879089002404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089002405 non-specific DNA binding site [nucleotide binding]; other site 879089002406 salt bridge; other site 879089002407 sequence-specific DNA binding site [nucleotide binding]; other site 879089002408 Cupin domain; Region: Cupin_2; pfam07883 879089002409 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 879089002410 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 879089002411 Walker A/P-loop; other site 879089002412 ATP binding site [chemical binding]; other site 879089002413 Q-loop/lid; other site 879089002414 ABC transporter signature motif; other site 879089002415 Walker B; other site 879089002416 D-loop; other site 879089002417 H-loop/switch region; other site 879089002418 TOBE domain; Region: TOBE_2; pfam08402 879089002419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 879089002420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089002421 putative PBP binding loops; other site 879089002422 ABC-ATPase subunit interface; other site 879089002423 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 879089002424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089002425 dimer interface [polypeptide binding]; other site 879089002426 conserved gate region; other site 879089002427 putative PBP binding loops; other site 879089002428 ABC-ATPase subunit interface; other site 879089002429 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 879089002430 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 879089002431 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 879089002432 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 879089002433 active site 879089002434 zinc binding site [ion binding]; other site 879089002435 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 879089002436 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 879089002437 Zn2+ binding site [ion binding]; other site 879089002438 Mg2+ binding site [ion binding]; other site 879089002439 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 879089002440 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 879089002441 nucleotide binding site [chemical binding]; other site 879089002442 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 879089002443 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 879089002444 FMN binding site [chemical binding]; other site 879089002445 substrate binding site [chemical binding]; other site 879089002446 putative catalytic residue [active] 879089002447 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 879089002448 MarR family; Region: MarR_2; pfam12802 879089002449 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 879089002450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089002451 Coenzyme A binding pocket [chemical binding]; other site 879089002452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 879089002453 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 879089002454 dimer interface [polypeptide binding]; other site 879089002455 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 879089002456 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 879089002457 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 879089002458 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 879089002459 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 879089002460 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089002461 motif II; other site 879089002462 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 879089002463 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 879089002464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089002465 Coenzyme A binding pocket [chemical binding]; other site 879089002466 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 879089002467 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 879089002468 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 879089002469 DNA binding residues [nucleotide binding] 879089002470 putative dimer interface [polypeptide binding]; other site 879089002471 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 879089002472 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 879089002473 active site 879089002474 catalytic tetrad [active] 879089002475 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 879089002476 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 879089002477 homodimer interface [polypeptide binding]; other site 879089002478 catalytic residues [active] 879089002479 NAD binding site [chemical binding]; other site 879089002480 substrate binding pocket [chemical binding]; other site 879089002481 flexible flap; other site 879089002482 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 879089002483 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 879089002484 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 879089002485 PhoU domain; Region: PhoU; pfam01895 879089002486 PhoU domain; Region: PhoU; pfam01895 879089002487 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 879089002488 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 879089002489 dimer interface [polypeptide binding]; other site 879089002490 PYR/PP interface [polypeptide binding]; other site 879089002491 TPP binding site [chemical binding]; other site 879089002492 substrate binding site [chemical binding]; other site 879089002493 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 879089002494 Domain of unknown function; Region: EKR; smart00890 879089002495 4Fe-4S binding domain; Region: Fer4_6; pfam12837 879089002496 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 879089002497 TPP-binding site [chemical binding]; other site 879089002498 dimer interface [polypeptide binding]; other site 879089002499 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 879089002500 Predicted permeases [General function prediction only]; Region: COG0679 879089002501 Helix-turn-helix domain; Region: HTH_28; pfam13518 879089002502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089002503 non-specific DNA binding site [nucleotide binding]; other site 879089002504 salt bridge; other site 879089002505 sequence-specific DNA binding site [nucleotide binding]; other site 879089002506 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 879089002507 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089002508 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089002509 Predicted membrane protein [Function unknown]; Region: COG3223 879089002510 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 879089002511 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 879089002512 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 879089002513 Walker A/P-loop; other site 879089002514 ATP binding site [chemical binding]; other site 879089002515 Q-loop/lid; other site 879089002516 ABC transporter signature motif; other site 879089002517 Walker B; other site 879089002518 D-loop; other site 879089002519 H-loop/switch region; other site 879089002520 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 879089002521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089002522 putative substrate translocation pore; other site 879089002523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089002524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089002525 Major Facilitator Superfamily; Region: MFS_1; pfam07690 879089002526 putative substrate translocation pore; other site 879089002527 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 879089002528 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 879089002529 putative DNA binding site [nucleotide binding]; other site 879089002530 putative Zn2+ binding site [ion binding]; other site 879089002531 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 879089002532 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 879089002533 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 879089002534 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 879089002535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089002536 motif II; other site 879089002537 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 879089002538 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089002539 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089002540 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089002541 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089002542 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089002543 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089002544 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089002545 Predicted membrane protein [Function unknown]; Region: COG3326 879089002546 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 879089002547 homotrimer interaction site [polypeptide binding]; other site 879089002548 putative active site [active] 879089002549 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 879089002550 substrate binding site [chemical binding]; other site 879089002551 zinc-binding site [ion binding]; other site 879089002552 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 879089002553 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 879089002554 GIY-YIG motif/motif A; other site 879089002555 active site 879089002556 catalytic site [active] 879089002557 putative DNA binding site [nucleotide binding]; other site 879089002558 metal binding site [ion binding]; metal-binding site 879089002559 UvrB/uvrC motif; Region: UVR; pfam02151 879089002560 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 879089002561 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 879089002562 substrate binding pocket [chemical binding]; other site 879089002563 membrane-bound complex binding site; other site 879089002564 hinge residues; other site 879089002565 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 879089002566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089002567 dimer interface [polypeptide binding]; other site 879089002568 conserved gate region; other site 879089002569 putative PBP binding loops; other site 879089002570 ABC-ATPase subunit interface; other site 879089002571 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 879089002572 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 879089002573 Walker A/P-loop; other site 879089002574 ATP binding site [chemical binding]; other site 879089002575 Q-loop/lid; other site 879089002576 ABC transporter signature motif; other site 879089002577 Walker B; other site 879089002578 D-loop; other site 879089002579 H-loop/switch region; other site 879089002580 amidase; Provisional; Region: PRK11910 879089002581 Amidase; Region: Amidase; cl11426 879089002582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 879089002583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 879089002584 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 879089002585 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 879089002586 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 879089002587 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 879089002588 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 879089002589 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 879089002590 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 879089002591 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 879089002592 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 879089002593 Esterase/lipase [General function prediction only]; Region: COG1647 879089002594 Transcriptional regulators [Transcription]; Region: PurR; COG1609 879089002595 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 879089002596 DNA binding site [nucleotide binding] 879089002597 domain linker motif; other site 879089002598 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 879089002599 putative dimerization interface [polypeptide binding]; other site 879089002600 putative ligand binding site [chemical binding]; other site 879089002601 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 879089002602 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 879089002603 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 879089002604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089002605 dimer interface [polypeptide binding]; other site 879089002606 conserved gate region; other site 879089002607 putative PBP binding loops; other site 879089002608 ABC-ATPase subunit interface; other site 879089002609 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 879089002610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089002611 dimer interface [polypeptide binding]; other site 879089002612 conserved gate region; other site 879089002613 ABC-ATPase subunit interface; other site 879089002614 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 879089002615 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 879089002616 Ca binding site [ion binding]; other site 879089002617 active site 879089002618 catalytic site [active] 879089002619 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 879089002620 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 879089002621 active site 879089002622 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 879089002623 active site 879089002624 substrate binding site [chemical binding]; other site 879089002625 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 879089002626 metal binding site [ion binding]; metal-binding site 879089002627 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 879089002628 DEAD-like helicases superfamily; Region: DEXDc; smart00487 879089002629 ATP binding site [chemical binding]; other site 879089002630 Mg++ binding site [ion binding]; other site 879089002631 motif III; other site 879089002632 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 879089002633 nucleotide binding region [chemical binding]; other site 879089002634 ATP-binding site [chemical binding]; other site 879089002635 Predicted membrane protein [Function unknown]; Region: COG4708 879089002636 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 879089002637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 879089002638 Predicted transcriptional regulators [Transcription]; Region: COG1733 879089002639 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 879089002640 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 879089002641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089002642 putative substrate translocation pore; other site 879089002643 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 879089002644 PRD domain; Region: PRD; pfam00874 879089002645 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 879089002646 active site 879089002647 P-loop; other site 879089002648 phosphorylation site [posttranslational modification] 879089002649 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089002650 active site 879089002651 phosphorylation site [posttranslational modification] 879089002652 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 879089002653 methionine cluster; other site 879089002654 active site 879089002655 phosphorylation site [posttranslational modification] 879089002656 metal binding site [ion binding]; metal-binding site 879089002657 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 879089002658 active site 879089002659 P-loop; other site 879089002660 phosphorylation site [posttranslational modification] 879089002661 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 879089002662 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 879089002663 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 879089002664 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 879089002665 active site 879089002666 trimer interface [polypeptide binding]; other site 879089002667 allosteric site; other site 879089002668 active site lid [active] 879089002669 hexamer (dimer of trimers) interface [polypeptide binding]; other site 879089002670 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 879089002671 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 879089002672 active site 879089002673 catalytic tetrad [active] 879089002674 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 879089002675 Collagen binding domain; Region: Collagen_bind; pfam05737 879089002676 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 879089002677 Uncharacterized conserved protein [Function unknown]; Region: COG3402 879089002678 Predicted membrane protein [Function unknown]; Region: COG3428 879089002679 Bacterial PH domain; Region: DUF304; pfam03703 879089002680 Bacterial PH domain; Region: DUF304; pfam03703 879089002681 Bacterial PH domain; Region: DUF304; pfam03703 879089002682 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 879089002683 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 879089002684 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 879089002685 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 879089002686 active site 879089002687 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 879089002688 dimer interface [polypeptide binding]; other site 879089002689 substrate binding site [chemical binding]; other site 879089002690 catalytic residues [active] 879089002691 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 879089002692 PemK-like protein; Region: PemK; pfam02452 879089002693 Rsbr N terminal; Region: Rsbr_N; pfam08678 879089002694 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 879089002695 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 879089002696 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 879089002697 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 879089002698 ATP binding site [chemical binding]; other site 879089002699 Mg2+ binding site [ion binding]; other site 879089002700 G-X-G motif; other site 879089002701 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 879089002702 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 879089002703 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 879089002704 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 879089002705 anti sigma factor interaction site; other site 879089002706 regulatory phosphorylation site [posttranslational modification]; other site 879089002707 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 879089002708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089002709 ATP binding site [chemical binding]; other site 879089002710 Mg2+ binding site [ion binding]; other site 879089002711 G-X-G motif; other site 879089002712 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 879089002713 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 879089002714 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 879089002715 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 879089002716 DNA binding residues [nucleotide binding] 879089002717 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 879089002718 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 879089002719 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 879089002720 Sulfate transporter family; Region: Sulfate_transp; pfam00916 879089002721 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 879089002722 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 879089002723 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 879089002724 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 879089002725 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 879089002726 RNA binding site [nucleotide binding]; other site 879089002727 hypothetical protein; Provisional; Region: PRK04351 879089002728 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 879089002729 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 879089002730 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 879089002731 Uncharacterized conserved protein [Function unknown]; Region: COG5646 879089002732 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 879089002733 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 879089002734 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 879089002735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089002736 DNA-binding site [nucleotide binding]; DNA binding site 879089002737 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 879089002738 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 879089002739 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 879089002740 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 879089002741 glutathione reductase; Validated; Region: PRK06116 879089002742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 879089002743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 879089002744 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 879089002745 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 879089002746 catalytic core [active] 879089002747 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 879089002748 Domain of unknown function DUF20; Region: UPF0118; pfam01594 879089002749 Predicted transcriptional regulators [Transcription]; Region: COG1725 879089002750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089002751 DNA-binding site [nucleotide binding]; DNA binding site 879089002752 Predicted membrane protein [General function prediction only]; Region: COG4194 879089002753 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 879089002754 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 879089002755 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 879089002756 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 879089002757 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 879089002758 tetramerization interface [polypeptide binding]; other site 879089002759 NAD(P) binding site [chemical binding]; other site 879089002760 catalytic residues [active] 879089002761 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 879089002762 active site 879089002763 P-loop; other site 879089002764 phosphorylation site [posttranslational modification] 879089002765 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 879089002766 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 879089002767 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 879089002768 methionine cluster; other site 879089002769 active site 879089002770 phosphorylation site [posttranslational modification] 879089002771 metal binding site [ion binding]; metal-binding site 879089002772 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 879089002773 beta-galactosidase; Region: BGL; TIGR03356 879089002774 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 879089002775 Mga helix-turn-helix domain; Region: Mga; pfam05043 879089002776 PRD domain; Region: PRD; pfam00874 879089002777 PRD domain; Region: PRD; pfam00874 879089002778 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089002779 active site 879089002780 phosphorylation site [posttranslational modification] 879089002781 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 879089002782 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 879089002783 ABC transporter; Region: ABC_tran_2; pfam12848 879089002784 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 879089002785 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 879089002786 Predicted permeases [General function prediction only]; Region: COG0701 879089002787 Predicted membrane protein [Function unknown]; Region: COG3689 879089002788 pantothenate kinase; Provisional; Region: PRK05439 879089002789 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 879089002790 ATP-binding site [chemical binding]; other site 879089002791 CoA-binding site [chemical binding]; other site 879089002792 Mg2+-binding site [ion binding]; other site 879089002793 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 879089002794 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 879089002795 Walker A/P-loop; other site 879089002796 ATP binding site [chemical binding]; other site 879089002797 Q-loop/lid; other site 879089002798 ABC transporter signature motif; other site 879089002799 Walker B; other site 879089002800 D-loop; other site 879089002801 H-loop/switch region; other site 879089002802 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 879089002803 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 879089002804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 879089002805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 879089002806 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 879089002807 Domain of unknown function (DUF373); Region: DUF373; cl12079 879089002808 Sulfatase; Region: Sulfatase; pfam00884 879089002809 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 879089002810 active site 879089002811 DNA binding site [nucleotide binding] 879089002812 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 879089002813 active site 879089002814 catalytic site [active] 879089002815 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 879089002816 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 879089002817 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 879089002818 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 879089002819 Uncharacterized conserved protein [Function unknown]; Region: COG0398 879089002820 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 879089002821 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 879089002822 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 879089002823 Ligand binding site; other site 879089002824 Putative Catalytic site; other site 879089002825 DXD motif; other site 879089002826 epoxyqueuosine reductase; Region: TIGR00276 879089002827 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 879089002828 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 879089002829 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 879089002830 dimer interface [polypeptide binding]; other site 879089002831 FMN binding site [chemical binding]; other site 879089002832 NADPH bind site [chemical binding]; other site 879089002833 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 879089002834 Low molecular weight phosphatase family; Region: LMWPc; cd00115 879089002835 active site 879089002836 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 879089002837 HSP90 family protein; Provisional; Region: PRK14083 879089002838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089002839 ATP binding site [chemical binding]; other site 879089002840 Mg2+ binding site [ion binding]; other site 879089002841 G-X-G motif; other site 879089002842 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 879089002843 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 879089002844 dimerization interface [polypeptide binding]; other site 879089002845 DPS ferroxidase diiron center [ion binding]; other site 879089002846 ion pore; other site 879089002847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 879089002848 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 879089002849 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 879089002850 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 879089002851 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 879089002852 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 879089002853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089002854 putative substrate translocation pore; other site 879089002855 Transcriptional regulators [Transcription]; Region: FadR; COG2186 879089002856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089002857 DNA-binding site [nucleotide binding]; DNA binding site 879089002858 FCD domain; Region: FCD; pfam07729 879089002859 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 879089002860 Domain of unknown function DUF20; Region: UPF0118; pfam01594 879089002861 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 879089002862 PGAP1-like protein; Region: PGAP1; pfam07819 879089002863 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 879089002864 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 879089002865 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 879089002866 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 879089002867 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 879089002868 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 879089002869 active site 879089002870 dimer interface [polypeptide binding]; other site 879089002871 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 879089002872 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 879089002873 active site 879089002874 trimer interface [polypeptide binding]; other site 879089002875 allosteric site; other site 879089002876 active site lid [active] 879089002877 hexamer (dimer of trimers) interface [polypeptide binding]; other site 879089002878 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 879089002879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089002880 DNA-binding site [nucleotide binding]; DNA binding site 879089002881 UTRA domain; Region: UTRA; pfam07702 879089002882 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 879089002883 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 879089002884 Mg++ binding site [ion binding]; other site 879089002885 putative catalytic motif [active] 879089002886 substrate binding site [chemical binding]; other site 879089002887 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 879089002888 Peptidase family U32; Region: Peptidase_U32; pfam01136 879089002889 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 879089002890 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 879089002891 Peptidase family U32; Region: Peptidase_U32; pfam01136 879089002892 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 879089002893 heat shock protein HtpX; Provisional; Region: PRK04897 879089002894 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 879089002895 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 879089002896 catalytic residues [active] 879089002897 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 879089002898 putative active site [active] 879089002899 putative metal binding residues [ion binding]; other site 879089002900 signature motif; other site 879089002901 putative triphosphate binding site [ion binding]; other site 879089002902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 879089002903 TPR motif; other site 879089002904 binding surface 879089002905 Tetratrico peptide repeat; Region: TPR_5; pfam12688 879089002906 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 879089002907 synthetase active site [active] 879089002908 NTP binding site [chemical binding]; other site 879089002909 metal binding site [ion binding]; metal-binding site 879089002910 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 879089002911 ATP-NAD kinase; Region: NAD_kinase; pfam01513 879089002912 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 879089002913 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 879089002914 active site 879089002915 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 879089002916 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 879089002917 NAD binding site [chemical binding]; other site 879089002918 homotetramer interface [polypeptide binding]; other site 879089002919 homodimer interface [polypeptide binding]; other site 879089002920 substrate binding site [chemical binding]; other site 879089002921 active site 879089002922 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 879089002923 DltD N-terminal region; Region: DltD_N; pfam04915 879089002924 DltD central region; Region: DltD_M; pfam04918 879089002925 DltD C-terminal region; Region: DltD_C; pfam04914 879089002926 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 879089002927 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 879089002928 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 879089002929 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 879089002930 acyl-activating enzyme (AAE) consensus motif; other site 879089002931 AMP binding site [chemical binding]; other site 879089002932 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 879089002933 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 879089002934 tetramer (dimer of dimers) interface [polypeptide binding]; other site 879089002935 active site 879089002936 dimer interface [polypeptide binding]; other site 879089002937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089002938 Coenzyme A binding pocket [chemical binding]; other site 879089002939 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 879089002940 Putative esterase; Region: Esterase; pfam00756 879089002941 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 879089002942 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 879089002943 homodimer interface [polypeptide binding]; other site 879089002944 substrate-cofactor binding pocket; other site 879089002945 catalytic residue [active] 879089002946 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 879089002947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089002948 Walker A/P-loop; other site 879089002949 ATP binding site [chemical binding]; other site 879089002950 Q-loop/lid; other site 879089002951 ABC transporter signature motif; other site 879089002952 Walker B; other site 879089002953 D-loop; other site 879089002954 H-loop/switch region; other site 879089002955 ABC-2 type transporter; Region: ABC2_membrane; cl17235 879089002956 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 879089002957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089002958 Major Facilitator Superfamily; Region: MFS_1; pfam07690 879089002959 putative substrate translocation pore; other site 879089002960 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 879089002961 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 879089002962 putative oligomer interface [polypeptide binding]; other site 879089002963 putative active site [active] 879089002964 metal binding site [ion binding]; metal-binding site 879089002965 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 879089002966 catalytic residues [active] 879089002967 dimer interface [polypeptide binding]; other site 879089002968 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 879089002969 LytTr DNA-binding domain; Region: LytTR; pfam04397 879089002970 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 879089002971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089002972 Walker A/P-loop; other site 879089002973 ATP binding site [chemical binding]; other site 879089002974 Q-loop/lid; other site 879089002975 ABC transporter signature motif; other site 879089002976 Walker B; other site 879089002977 D-loop; other site 879089002978 H-loop/switch region; other site 879089002979 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 879089002980 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 879089002981 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 879089002982 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 879089002983 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 879089002984 G1 box; other site 879089002985 putative GEF interaction site [polypeptide binding]; other site 879089002986 GTP/Mg2+ binding site [chemical binding]; other site 879089002987 Switch I region; other site 879089002988 G2 box; other site 879089002989 G3 box; other site 879089002990 Switch II region; other site 879089002991 G4 box; other site 879089002992 G5 box; other site 879089002993 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 879089002994 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 879089002995 MarR family; Region: MarR_2; cl17246 879089002996 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 879089002997 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 879089002998 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 879089002999 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 879089003000 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 879089003001 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 879089003002 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 879089003003 Acyltransferase family; Region: Acyl_transf_3; pfam01757 879089003004 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 879089003005 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 879089003006 DNA binding site [nucleotide binding] 879089003007 active site 879089003008 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 879089003009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089003010 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 879089003011 Walker A motif; other site 879089003012 ATP binding site [chemical binding]; other site 879089003013 Walker B motif; other site 879089003014 arginine finger; other site 879089003015 UvrB/uvrC motif; Region: UVR; pfam02151 879089003016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089003017 Walker A motif; other site 879089003018 ATP binding site [chemical binding]; other site 879089003019 Walker B motif; other site 879089003020 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 879089003021 CAAX protease self-immunity; Region: Abi; pfam02517 879089003022 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 879089003023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 879089003024 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 879089003025 nucleotide binding site [chemical binding]; other site 879089003026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 879089003027 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 879089003028 dimerization domain swap beta strand [polypeptide binding]; other site 879089003029 regulatory protein interface [polypeptide binding]; other site 879089003030 active site 879089003031 regulatory phosphorylation site [posttranslational modification]; other site 879089003032 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 879089003033 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 879089003034 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 879089003035 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 879089003036 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 879089003037 Uncharacterized conserved protein [Function unknown]; Region: COG1434 879089003038 putative active site [active] 879089003039 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 879089003040 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 879089003041 aminotransferase A; Validated; Region: PRK07683 879089003042 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 879089003043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089003044 homodimer interface [polypeptide binding]; other site 879089003045 catalytic residue [active] 879089003046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 879089003047 FOG: CBS domain [General function prediction only]; Region: COG0517 879089003048 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 879089003049 Transcriptional regulator [Transcription]; Region: LysR; COG0583 879089003050 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 879089003051 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 879089003052 dimerization interface [polypeptide binding]; other site 879089003053 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 879089003054 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 879089003055 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 879089003056 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 879089003057 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 879089003058 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 879089003059 metal binding site [ion binding]; metal-binding site 879089003060 putative dimer interface [polypeptide binding]; other site 879089003061 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 879089003062 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 879089003063 Mechanosensitive ion channel; Region: MS_channel; pfam00924 879089003064 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 879089003065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089003066 Walker A/P-loop; other site 879089003067 ATP binding site [chemical binding]; other site 879089003068 Q-loop/lid; other site 879089003069 ABC transporter signature motif; other site 879089003070 Walker B; other site 879089003071 D-loop; other site 879089003072 H-loop/switch region; other site 879089003073 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 879089003074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089003075 dimer interface [polypeptide binding]; other site 879089003076 conserved gate region; other site 879089003077 putative PBP binding loops; other site 879089003078 ABC-ATPase subunit interface; other site 879089003079 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 879089003080 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 879089003081 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 879089003082 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 879089003083 HPr interaction site; other site 879089003084 glycerol kinase (GK) interaction site [polypeptide binding]; other site 879089003085 active site 879089003086 phosphorylation site [posttranslational modification] 879089003087 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 879089003088 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 879089003089 S1 domain; Region: S1_2; pfam13509 879089003090 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 879089003091 RNA binding site [nucleotide binding]; other site 879089003092 Predicted membrane protein [Function unknown]; Region: COG4758 879089003093 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 879089003094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 879089003095 Histidine kinase; Region: HisKA_3; pfam07730 879089003096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089003097 ATP binding site [chemical binding]; other site 879089003098 Mg2+ binding site [ion binding]; other site 879089003099 G-X-G motif; other site 879089003100 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 879089003101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089003102 active site 879089003103 phosphorylation site [posttranslational modification] 879089003104 intermolecular recognition site; other site 879089003105 dimerization interface [polypeptide binding]; other site 879089003106 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 879089003107 DNA binding residues [nucleotide binding] 879089003108 dimerization interface [polypeptide binding]; other site 879089003109 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 879089003110 TrkA-N domain; Region: TrkA_N; pfam02254 879089003111 TrkA-C domain; Region: TrkA_C; pfam02080 879089003112 Predicted membrane protein [Function unknown]; Region: COG1289 879089003113 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 879089003114 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 879089003115 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 879089003116 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 879089003117 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 879089003118 hypothetical protein; Provisional; Region: PRK13667 879089003119 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 879089003120 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089003121 active site 879089003122 motif I; other site 879089003123 motif II; other site 879089003124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089003125 Transcriptional regulators [Transcription]; Region: PurR; COG1609 879089003126 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 879089003127 DNA binding site [nucleotide binding] 879089003128 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 879089003129 ligand binding site [chemical binding]; other site 879089003130 dimerization interface [polypeptide binding]; other site 879089003131 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 879089003132 hexamer (dimer of trimers) interface [polypeptide binding]; other site 879089003133 trimer interface [polypeptide binding]; other site 879089003134 substrate binding site [chemical binding]; other site 879089003135 Mn binding site [ion binding]; other site 879089003136 transketolase; Reviewed; Region: PRK05899 879089003137 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 879089003138 TPP-binding site [chemical binding]; other site 879089003139 dimer interface [polypeptide binding]; other site 879089003140 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 879089003141 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 879089003142 PYR/PP interface [polypeptide binding]; other site 879089003143 dimer interface [polypeptide binding]; other site 879089003144 TPP binding site [chemical binding]; other site 879089003145 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 879089003146 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 879089003147 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 879089003148 nucleotide binding site [chemical binding]; other site 879089003149 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 879089003150 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 879089003151 active site turn [active] 879089003152 phosphorylation site [posttranslational modification] 879089003153 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 879089003154 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 879089003155 HPr interaction site; other site 879089003156 glycerol kinase (GK) interaction site [polypeptide binding]; other site 879089003157 active site 879089003158 phosphorylation site [posttranslational modification] 879089003159 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 879089003160 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 879089003161 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 879089003162 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 879089003163 GTP binding site; other site 879089003164 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 879089003165 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 879089003166 Walker A/P-loop; other site 879089003167 ATP binding site [chemical binding]; other site 879089003168 Q-loop/lid; other site 879089003169 ABC transporter signature motif; other site 879089003170 Walker B; other site 879089003171 D-loop; other site 879089003172 H-loop/switch region; other site 879089003173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089003174 dimer interface [polypeptide binding]; other site 879089003175 conserved gate region; other site 879089003176 putative PBP binding loops; other site 879089003177 ABC-ATPase subunit interface; other site 879089003178 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 879089003179 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 879089003180 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 879089003181 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 879089003182 dimer interface [polypeptide binding]; other site 879089003183 putative functional site; other site 879089003184 putative MPT binding site; other site 879089003185 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 879089003186 Walker A motif; other site 879089003187 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 879089003188 MoaE homodimer interface [polypeptide binding]; other site 879089003189 MoaD interaction [polypeptide binding]; other site 879089003190 active site residues [active] 879089003191 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 879089003192 MoaE interaction surface [polypeptide binding]; other site 879089003193 MoeB interaction surface [polypeptide binding]; other site 879089003194 thiocarboxylated glycine; other site 879089003195 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 879089003196 trimer interface [polypeptide binding]; other site 879089003197 dimer interface [polypeptide binding]; other site 879089003198 putative active site [active] 879089003199 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 879089003200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 879089003201 FeS/SAM binding site; other site 879089003202 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 879089003203 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 879089003204 MPT binding site; other site 879089003205 trimer interface [polypeptide binding]; other site 879089003206 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 879089003207 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 879089003208 ATP binding site [chemical binding]; other site 879089003209 substrate interface [chemical binding]; other site 879089003210 Flavin Reductases; Region: FlaRed; cl00801 879089003211 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 879089003212 active site 879089003213 catalytic residues [active] 879089003214 metal binding site [ion binding]; metal-binding site 879089003215 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 879089003216 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 879089003217 TPP-binding site [chemical binding]; other site 879089003218 tetramer interface [polypeptide binding]; other site 879089003219 heterodimer interface [polypeptide binding]; other site 879089003220 phosphorylation loop region [posttranslational modification] 879089003221 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 879089003222 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 879089003223 alpha subunit interface [polypeptide binding]; other site 879089003224 TPP binding site [chemical binding]; other site 879089003225 heterodimer interface [polypeptide binding]; other site 879089003226 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 879089003227 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 879089003228 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 879089003229 E3 interaction surface; other site 879089003230 lipoyl attachment site [posttranslational modification]; other site 879089003231 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 879089003232 E3 interaction surface; other site 879089003233 lipoyl attachment site [posttranslational modification]; other site 879089003234 e3 binding domain; Region: E3_binding; pfam02817 879089003235 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 879089003236 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 879089003237 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 879089003238 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 879089003239 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 879089003240 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 879089003241 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 879089003242 NAD(P) binding site [chemical binding]; other site 879089003243 LDH/MDH dimer interface [polypeptide binding]; other site 879089003244 substrate binding site [chemical binding]; other site 879089003245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476 879089003246 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 879089003247 Thioredoxin; Region: Thioredoxin_4; pfam13462 879089003248 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 879089003249 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 879089003250 Cl binding site [ion binding]; other site 879089003251 oligomer interface [polypeptide binding]; other site 879089003252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 879089003253 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 879089003254 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 879089003255 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 879089003256 active site 879089003257 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 879089003258 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 879089003259 G1 box; other site 879089003260 putative GEF interaction site [polypeptide binding]; other site 879089003261 GTP/Mg2+ binding site [chemical binding]; other site 879089003262 Switch I region; other site 879089003263 G2 box; other site 879089003264 G3 box; other site 879089003265 Switch II region; other site 879089003266 G4 box; other site 879089003267 G5 box; other site 879089003268 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 879089003269 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 879089003270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 879089003271 hypothetical protein; Provisional; Region: PRK13666 879089003272 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 879089003273 pyruvate carboxylase; Reviewed; Region: PRK12999 879089003274 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 879089003275 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 879089003276 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 879089003277 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 879089003278 active site 879089003279 catalytic residues [active] 879089003280 metal binding site [ion binding]; metal-binding site 879089003281 homodimer binding site [polypeptide binding]; other site 879089003282 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 879089003283 carboxyltransferase (CT) interaction site; other site 879089003284 biotinylation site [posttranslational modification]; other site 879089003285 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 879089003286 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 879089003287 putative binding site residues; other site 879089003288 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 879089003289 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 879089003290 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 879089003291 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 879089003292 Walker A/P-loop; other site 879089003293 ATP binding site [chemical binding]; other site 879089003294 Q-loop/lid; other site 879089003295 ABC transporter signature motif; other site 879089003296 Walker B; other site 879089003297 D-loop; other site 879089003298 H-loop/switch region; other site 879089003299 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 879089003300 SH3-like domain; Region: SH3_8; pfam13457 879089003301 SH3-like domain; Region: SH3_8; pfam13457 879089003302 SH3-like domain; Region: SH3_8; pfam13457 879089003303 SH3-like domain; Region: SH3_8; pfam13457 879089003304 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 879089003305 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 879089003306 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 879089003307 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 879089003308 active site 879089003309 tetramer interface; other site 879089003310 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 879089003311 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 879089003312 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 879089003313 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 879089003314 active site 879089003315 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 879089003316 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 879089003317 substrate binding site; other site 879089003318 tetramer interface; other site 879089003319 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 879089003320 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 879089003321 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 879089003322 NAD binding site [chemical binding]; other site 879089003323 substrate binding site [chemical binding]; other site 879089003324 homodimer interface [polypeptide binding]; other site 879089003325 active site 879089003326 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 879089003327 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 879089003328 NADP binding site [chemical binding]; other site 879089003329 active site 879089003330 putative substrate binding site [chemical binding]; other site 879089003331 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 879089003332 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 879089003333 substrate binding site; other site 879089003334 dimer interface; other site 879089003335 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 879089003336 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 879089003337 putative NAD(P) binding site [chemical binding]; other site 879089003338 putative catalytic Zn binding site [ion binding]; other site 879089003339 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 879089003340 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 879089003341 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 879089003342 active site 879089003343 putative glycosyl transferase; Provisional; Region: PRK10073 879089003344 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 879089003345 active site 879089003346 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 879089003347 active site 879089003348 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 879089003349 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 879089003350 active site 879089003351 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 879089003352 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 879089003353 homodimer interface [polypeptide binding]; other site 879089003354 NAD binding pocket [chemical binding]; other site 879089003355 ATP binding pocket [chemical binding]; other site 879089003356 Mg binding site [ion binding]; other site 879089003357 active-site loop [active] 879089003358 Uncharacterized conserved protein [Function unknown]; Region: COG1359 879089003359 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 879089003360 active site 879089003361 P-loop; other site 879089003362 phosphorylation site [posttranslational modification] 879089003363 GMP synthase; Reviewed; Region: guaA; PRK00074 879089003364 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 879089003365 AMP/PPi binding site [chemical binding]; other site 879089003366 candidate oxyanion hole; other site 879089003367 catalytic triad [active] 879089003368 potential glutamine specificity residues [chemical binding]; other site 879089003369 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 879089003370 ATP Binding subdomain [chemical binding]; other site 879089003371 Dimerization subdomain; other site 879089003372 Protein of unknown function DUF262; Region: DUF262; pfam03235 879089003373 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 879089003374 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 879089003375 cofactor binding site; other site 879089003376 DNA binding site [nucleotide binding] 879089003377 substrate interaction site [chemical binding]; other site 879089003378 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 879089003379 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 879089003380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 879089003381 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 879089003382 Coenzyme A binding pocket [chemical binding]; other site 879089003383 MepB protein; Region: MepB; cl01985 879089003384 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 879089003385 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 879089003386 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 879089003387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089003388 Coenzyme A binding pocket [chemical binding]; other site 879089003389 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 879089003390 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 879089003391 DNA binding residues [nucleotide binding] 879089003392 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 879089003393 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 879089003394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089003395 Walker A/P-loop; other site 879089003396 ATP binding site [chemical binding]; other site 879089003397 Q-loop/lid; other site 879089003398 ABC transporter signature motif; other site 879089003399 Walker B; other site 879089003400 D-loop; other site 879089003401 H-loop/switch region; other site 879089003402 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 879089003403 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 879089003404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089003405 Walker A/P-loop; other site 879089003406 ATP binding site [chemical binding]; other site 879089003407 Q-loop/lid; other site 879089003408 ABC transporter signature motif; other site 879089003409 Walker B; other site 879089003410 D-loop; other site 879089003411 H-loop/switch region; other site 879089003412 Uncharacterized conserved protein [Function unknown]; Region: COG1359 879089003413 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 879089003414 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 879089003415 DNA binding residues [nucleotide binding] 879089003416 putative dimer interface [polypeptide binding]; other site 879089003417 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 879089003418 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 879089003419 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 879089003420 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 879089003421 LRR adjacent; Region: LRR_adjacent; pfam08191 879089003422 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089003423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 879089003424 Clp protease; Region: CLP_protease; pfam00574 879089003425 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 879089003426 oligomer interface [polypeptide binding]; other site 879089003427 active site residues [active] 879089003428 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 879089003429 dimer interface [polypeptide binding]; other site 879089003430 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 879089003431 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 879089003432 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 879089003433 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 879089003434 SLBB domain; Region: SLBB; pfam10531 879089003435 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 879089003436 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 879089003437 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 879089003438 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 879089003439 putative hexamer interface [polypeptide binding]; other site 879089003440 putative hexagonal pore; other site 879089003441 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 879089003442 putative hexamer interface [polypeptide binding]; other site 879089003443 putative hexagonal pore; other site 879089003444 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 879089003445 putative hexamer interface [polypeptide binding]; other site 879089003446 putative hexagonal pore; other site 879089003447 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 879089003448 G1 box; other site 879089003449 GTP/Mg2+ binding site [chemical binding]; other site 879089003450 G2 box; other site 879089003451 Switch I region; other site 879089003452 G3 box; other site 879089003453 Switch II region; other site 879089003454 G4 box; other site 879089003455 G5 box; other site 879089003456 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 879089003457 homotrimer interface [polypeptide binding]; other site 879089003458 Walker A motif; other site 879089003459 GTP binding site [chemical binding]; other site 879089003460 Walker B motif; other site 879089003461 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 879089003462 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 879089003463 catalytic core [active] 879089003464 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 879089003465 Sensory domain found in PocR; Region: PocR; pfam10114 879089003466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 879089003467 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 879089003468 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 879089003469 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 879089003470 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 879089003471 Hexamer interface [polypeptide binding]; other site 879089003472 Hexagonal pore residue; other site 879089003473 propanediol utilization protein PduB; Provisional; Region: PRK15415 879089003474 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 879089003475 putative hexamer interface [polypeptide binding]; other site 879089003476 putative hexagonal pore; other site 879089003477 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 879089003478 putative hexamer interface [polypeptide binding]; other site 879089003479 putative hexagonal pore; other site 879089003480 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 879089003481 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 879089003482 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 879089003483 alpha-beta subunit interface [polypeptide binding]; other site 879089003484 alpha-gamma subunit interface [polypeptide binding]; other site 879089003485 active site 879089003486 substrate and K+ binding site; other site 879089003487 K+ binding site [ion binding]; other site 879089003488 cobalamin binding site [chemical binding]; other site 879089003489 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 879089003490 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 879089003491 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 879089003492 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 879089003493 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 879089003494 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 879089003495 putative hexamer interface [polypeptide binding]; other site 879089003496 putative hexagonal pore; other site 879089003497 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 879089003498 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 879089003499 Hexamer interface [polypeptide binding]; other site 879089003500 Hexagonal pore residue; other site 879089003501 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 879089003502 Propanediol utilisation protein PduL; Region: PduL; pfam06130 879089003503 Propanediol utilisation protein PduL; Region: PduL; pfam06130 879089003504 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 879089003505 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 879089003506 nucleotide binding site [chemical binding]; other site 879089003507 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 879089003508 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 879089003509 Hexamer/Pentamer interface [polypeptide binding]; other site 879089003510 central pore; other site 879089003511 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 879089003512 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 879089003513 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 879089003514 putative catalytic cysteine [active] 879089003515 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 879089003516 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 879089003517 putative active site [active] 879089003518 metal binding site [ion binding]; metal-binding site 879089003519 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 879089003520 amphipathic channel; other site 879089003521 Asn-Pro-Ala signature motifs; other site 879089003522 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 879089003523 propionate/acetate kinase; Provisional; Region: PRK12379 879089003524 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 879089003525 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 879089003526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089003527 homodimer interface [polypeptide binding]; other site 879089003528 catalytic residue [active] 879089003529 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 879089003530 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 879089003531 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 879089003532 putative active site [active] 879089003533 metal binding site [ion binding]; metal-binding site 879089003534 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 879089003535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089003536 active site 879089003537 phosphorylation site [posttranslational modification] 879089003538 intermolecular recognition site; other site 879089003539 dimerization interface [polypeptide binding]; other site 879089003540 ANTAR domain; Region: ANTAR; pfam03861 879089003541 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 879089003542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 879089003543 Histidine kinase; Region: HisKA_2; pfam07568 879089003544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089003545 ATP binding site [chemical binding]; other site 879089003546 Mg2+ binding site [ion binding]; other site 879089003547 G-X-G motif; other site 879089003548 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 879089003549 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 879089003550 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 879089003551 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 879089003552 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 879089003553 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 879089003554 putative hexamer interface [polypeptide binding]; other site 879089003555 putative hexagonal pore; other site 879089003556 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 879089003557 putative hexamer interface [polypeptide binding]; other site 879089003558 putative hexagonal pore; other site 879089003559 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 879089003560 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 879089003561 Hexamer interface [polypeptide binding]; other site 879089003562 Hexagonal pore residue; other site 879089003563 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 879089003564 putative catalytic cysteine [active] 879089003565 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 879089003566 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 879089003567 Hexamer interface [polypeptide binding]; other site 879089003568 Putative hexagonal pore residue; other site 879089003569 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 879089003570 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 879089003571 Propanediol utilisation protein PduL; Region: PduL; pfam06130 879089003572 Propanediol utilisation protein PduL; Region: PduL; pfam06130 879089003573 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 879089003574 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 879089003575 Hexamer/Pentamer interface [polypeptide binding]; other site 879089003576 central pore; other site 879089003577 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 879089003578 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 879089003579 putative hexamer interface [polypeptide binding]; other site 879089003580 putative hexagonal pore; other site 879089003581 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 879089003582 putative hexamer interface [polypeptide binding]; other site 879089003583 putative hexagonal pore; other site 879089003584 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 879089003585 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 879089003586 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 879089003587 hypothetical protein; Region: PHA01818 879089003588 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 879089003589 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 879089003590 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 879089003591 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 879089003592 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 879089003593 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 879089003594 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 879089003595 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 879089003596 catalytic triad [active] 879089003597 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 879089003598 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 879089003599 Precorrin-8X methylmutase; Region: CbiC; pfam02570 879089003600 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 879089003601 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 879089003602 active site 879089003603 putative homodimer interface [polypeptide binding]; other site 879089003604 SAM binding site [chemical binding]; other site 879089003605 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 879089003606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089003607 S-adenosylmethionine binding site [chemical binding]; other site 879089003608 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 879089003609 active site 879089003610 SAM binding site [chemical binding]; other site 879089003611 homodimer interface [polypeptide binding]; other site 879089003612 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 879089003613 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 879089003614 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 879089003615 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 879089003616 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 879089003617 active site 879089003618 SAM binding site [chemical binding]; other site 879089003619 homodimer interface [polypeptide binding]; other site 879089003620 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 879089003621 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 879089003622 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 879089003623 active site 879089003624 SAM binding site [chemical binding]; other site 879089003625 homodimer interface [polypeptide binding]; other site 879089003626 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 879089003627 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 879089003628 active site 879089003629 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 879089003630 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 879089003631 active site 879089003632 C-terminal domain interface [polypeptide binding]; other site 879089003633 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 879089003634 active site 879089003635 N-terminal domain interface [polypeptide binding]; other site 879089003636 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 879089003637 active site 879089003638 SAM binding site [chemical binding]; other site 879089003639 homodimer interface [polypeptide binding]; other site 879089003640 cobalt transport protein CbiM; Validated; Region: PRK08319 879089003641 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 879089003642 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 879089003643 cobalt transport protein CbiQ; Provisional; Region: PRK15485 879089003644 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 879089003645 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 879089003646 Walker A/P-loop; other site 879089003647 ATP binding site [chemical binding]; other site 879089003648 Q-loop/lid; other site 879089003649 ABC transporter signature motif; other site 879089003650 Walker B; other site 879089003651 D-loop; other site 879089003652 H-loop/switch region; other site 879089003653 cobyric acid synthase; Provisional; Region: PRK00784 879089003654 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 879089003655 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 879089003656 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 879089003657 catalytic triad [active] 879089003658 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 879089003659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 879089003660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 879089003661 AAA domain; Region: AAA_17; cl17253 879089003662 Predicted transcriptional regulators [Transcription]; Region: COG1695 879089003663 Transcriptional regulator PadR-like family; Region: PadR; cl17335 879089003664 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 879089003665 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 879089003666 SH3-like domain; Region: SH3_8; pfam13457 879089003667 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 879089003668 SH3-like domain; Region: SH3_8; pfam13457 879089003669 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 879089003670 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 879089003671 oligomer interface [polypeptide binding]; other site 879089003672 active site 879089003673 metal binding site [ion binding]; metal-binding site 879089003674 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 879089003675 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 879089003676 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 879089003677 Predicted transcriptional regulators [Transcription]; Region: COG1733 879089003678 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 879089003679 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 879089003680 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 879089003681 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 879089003682 dimer interface [polypeptide binding]; other site 879089003683 motif 1; other site 879089003684 active site 879089003685 motif 2; other site 879089003686 motif 3; other site 879089003687 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 879089003688 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 879089003689 putative tRNA-binding site [nucleotide binding]; other site 879089003690 B3/4 domain; Region: B3_4; pfam03483 879089003691 tRNA synthetase B5 domain; Region: B5; smart00874 879089003692 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 879089003693 dimer interface [polypeptide binding]; other site 879089003694 motif 1; other site 879089003695 motif 3; other site 879089003696 motif 2; other site 879089003697 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 879089003698 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 879089003699 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 879089003700 Walker A/P-loop; other site 879089003701 ATP binding site [chemical binding]; other site 879089003702 Q-loop/lid; other site 879089003703 ABC transporter signature motif; other site 879089003704 Walker B; other site 879089003705 D-loop; other site 879089003706 H-loop/switch region; other site 879089003707 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 879089003708 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 879089003709 dimer interface [polypeptide binding]; other site 879089003710 FtsX-like permease family; Region: FtsX; pfam02687 879089003711 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 879089003712 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 879089003713 FtsX-like permease family; Region: FtsX; pfam02687 879089003714 Transcriptional regulators [Transcription]; Region: MarR; COG1846 879089003715 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 879089003716 putative DNA binding site [nucleotide binding]; other site 879089003717 putative Zn2+ binding site [ion binding]; other site 879089003718 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 879089003719 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 879089003720 ligand binding site [chemical binding]; other site 879089003721 active site 879089003722 UGI interface [polypeptide binding]; other site 879089003723 catalytic site [active] 879089003724 ribonuclease HIII; Provisional; Region: PRK00996 879089003725 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 879089003726 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 879089003727 RNA/DNA hybrid binding site [nucleotide binding]; other site 879089003728 active site 879089003729 Cell division protein ZapA; Region: ZapA; cl01146 879089003730 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 879089003731 Colicin V production protein; Region: Colicin_V; pfam02674 879089003732 hypothetical protein; Provisional; Region: PRK08609 879089003733 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 879089003734 active site 879089003735 primer binding site [nucleotide binding]; other site 879089003736 NTP binding site [chemical binding]; other site 879089003737 metal binding triad [ion binding]; metal-binding site 879089003738 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 879089003739 active site 879089003740 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 879089003741 MutS domain III; Region: MutS_III; pfam05192 879089003742 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089003743 Walker A/P-loop; other site 879089003744 ATP binding site [chemical binding]; other site 879089003745 Q-loop/lid; other site 879089003746 ABC transporter signature motif; other site 879089003747 Walker B; other site 879089003748 D-loop; other site 879089003749 H-loop/switch region; other site 879089003750 Smr domain; Region: Smr; pfam01713 879089003751 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 879089003752 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 879089003753 catalytic residues [active] 879089003754 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 879089003755 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 879089003756 GIY-YIG motif/motif A; other site 879089003757 active site 879089003758 catalytic site [active] 879089003759 putative DNA binding site [nucleotide binding]; other site 879089003760 metal binding site [ion binding]; metal-binding site 879089003761 UvrB/uvrC motif; Region: UVR; pfam02151 879089003762 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 879089003763 aspartate kinase; Reviewed; Region: PRK06635 879089003764 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 879089003765 putative nucleotide binding site [chemical binding]; other site 879089003766 putative catalytic residues [active] 879089003767 putative Mg ion binding site [ion binding]; other site 879089003768 putative aspartate binding site [chemical binding]; other site 879089003769 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 879089003770 putative allosteric regulatory site; other site 879089003771 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 879089003772 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 879089003773 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 879089003774 ribonuclease PH; Reviewed; Region: rph; PRK00173 879089003775 Ribonuclease PH; Region: RNase_PH_bact; cd11362 879089003776 hexamer interface [polypeptide binding]; other site 879089003777 active site 879089003778 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 879089003779 active site 879089003780 dimerization interface [polypeptide binding]; other site 879089003781 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 879089003782 active site 879089003783 metal binding site [ion binding]; metal-binding site 879089003784 homotetramer interface [polypeptide binding]; other site 879089003785 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 879089003786 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 879089003787 Int/Topo IB signature motif; other site 879089003788 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 879089003789 Domain of unknown function (DUF955); Region: DUF955; pfam06114 879089003790 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 879089003791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089003792 non-specific DNA binding site [nucleotide binding]; other site 879089003793 salt bridge; other site 879089003794 sequence-specific DNA binding site [nucleotide binding]; other site 879089003795 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 879089003796 salt bridge; other site 879089003797 non-specific DNA binding site [nucleotide binding]; other site 879089003798 sequence-specific DNA binding site [nucleotide binding]; other site 879089003799 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 879089003800 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 879089003801 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 879089003802 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 879089003803 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 879089003804 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 879089003805 AAA domain; Region: AAA_24; pfam13479 879089003806 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 879089003807 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 879089003808 ATP binding site [chemical binding]; other site 879089003809 putative Mg++ binding site [ion binding]; other site 879089003810 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 879089003811 nucleotide binding region [chemical binding]; other site 879089003812 ATP-binding site [chemical binding]; other site 879089003813 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 879089003814 Protein of unknown function (DUF669); Region: DUF669; pfam05037 879089003815 Uncharacterized conserved protein [Function unknown]; Region: COG4983 879089003816 Phage associated DNA primase [General function prediction only]; Region: COG3378 879089003817 D5 N terminal like; Region: D5_N; pfam08706 879089003818 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 879089003819 VRR-NUC domain; Region: VRR_NUC; pfam08774 879089003820 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 879089003821 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 879089003822 Protein of unknown function (DUF722); Region: DUF722; pfam05263 879089003823 Phage terminase, small subunit; Region: Terminase_4; cl01525 879089003824 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 879089003825 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 879089003826 Phage portal protein; Region: Phage_portal; pfam04860 879089003827 Phage-related protein [Function unknown]; Region: COG4695; cl01923 879089003828 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 879089003829 oligomer interface [polypeptide binding]; other site 879089003830 active site residues [active] 879089003831 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 879089003832 Phage capsid family; Region: Phage_capsid; pfam05065 879089003833 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 879089003834 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 879089003835 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 879089003836 N-acetyl-D-glucosamine binding site [chemical binding]; other site 879089003837 catalytic residue [active] 879089003838 Phage tail protein; Region: Sipho_tail; cl17486 879089003839 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 879089003840 Bacteriophage holin; Region: Phage_holin_1; pfam04531 879089003841 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 879089003842 Abi-like protein; Region: Abi_2; pfam07751 879089003843 AP2 domain; Region: AP2; pfam00847 879089003844 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 879089003845 LRR adjacent; Region: LRR_adjacent; pfam08191 879089003846 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089003847 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089003848 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089003849 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089003850 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089003851 Uncharacterized conserved protein [Function unknown]; Region: COG5361 879089003852 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 879089003853 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 879089003854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 879089003855 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 879089003856 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 879089003857 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 879089003858 dimer interface [polypeptide binding]; other site 879089003859 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 879089003860 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 879089003861 catalytic core [active] 879089003862 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 879089003863 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 879089003864 ATP binding site [chemical binding]; other site 879089003865 Mg++ binding site [ion binding]; other site 879089003866 motif III; other site 879089003867 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 879089003868 nucleotide binding region [chemical binding]; other site 879089003869 ATP-binding site [chemical binding]; other site 879089003870 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 879089003871 RNA binding site [nucleotide binding]; other site 879089003872 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 879089003873 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 879089003874 putative active site [active] 879089003875 nucleotide binding site [chemical binding]; other site 879089003876 nudix motif; other site 879089003877 putative metal binding site [ion binding]; other site 879089003878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089003879 Major Facilitator Superfamily; Region: MFS_1; pfam07690 879089003880 putative substrate translocation pore; other site 879089003881 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089003882 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 879089003883 ligand binding site [chemical binding]; other site 879089003884 flexible hinge region; other site 879089003885 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 879089003886 Uncharacterized conserved protein [Function unknown]; Region: COG1284 879089003887 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 879089003888 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 879089003889 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 879089003890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089003891 DNA-binding site [nucleotide binding]; DNA binding site 879089003892 UTRA domain; Region: UTRA; pfam07702 879089003893 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 879089003894 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 879089003895 Ca binding site [ion binding]; other site 879089003896 active site 879089003897 catalytic site [active] 879089003898 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 879089003899 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 879089003900 active site turn [active] 879089003901 phosphorylation site [posttranslational modification] 879089003902 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 879089003903 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 879089003904 nudix motif; other site 879089003905 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 879089003906 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 879089003907 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 879089003908 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 879089003909 putative catalytic cysteine [active] 879089003910 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 879089003911 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 879089003912 nucleotide binding site [chemical binding]; other site 879089003913 homotetrameric interface [polypeptide binding]; other site 879089003914 putative phosphate binding site [ion binding]; other site 879089003915 putative allosteric binding site; other site 879089003916 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 879089003917 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 879089003918 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 879089003919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089003920 non-specific DNA binding site [nucleotide binding]; other site 879089003921 salt bridge; other site 879089003922 sequence-specific DNA binding site [nucleotide binding]; other site 879089003923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089003924 non-specific DNA binding site [nucleotide binding]; other site 879089003925 salt bridge; other site 879089003926 sequence-specific DNA binding site [nucleotide binding]; other site 879089003927 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 879089003928 active site 879089003929 trigger factor; Provisional; Region: tig; PRK01490 879089003930 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 879089003931 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 879089003932 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 879089003933 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 879089003934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089003935 Walker A motif; other site 879089003936 ATP binding site [chemical binding]; other site 879089003937 Walker B motif; other site 879089003938 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 879089003939 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 879089003940 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 879089003941 Catalytic site [active] 879089003942 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 879089003943 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 879089003944 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 879089003945 Catalytic site [active] 879089003946 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 879089003947 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 879089003948 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 879089003949 Catalytic site [active] 879089003950 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 879089003951 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 879089003952 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 879089003953 GTP/Mg2+ binding site [chemical binding]; other site 879089003954 G4 box; other site 879089003955 G5 box; other site 879089003956 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 879089003957 G1 box; other site 879089003958 G1 box; other site 879089003959 GTP/Mg2+ binding site [chemical binding]; other site 879089003960 Switch I region; other site 879089003961 G2 box; other site 879089003962 G2 box; other site 879089003963 G3 box; other site 879089003964 G3 box; other site 879089003965 Switch II region; other site 879089003966 Switch II region; other site 879089003967 G5 box; other site 879089003968 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 879089003969 RNA/DNA hybrid binding site [nucleotide binding]; other site 879089003970 active site 879089003971 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 879089003972 DNA protecting protein DprA; Region: dprA; TIGR00732 879089003973 DNA topoisomerase I; Validated; Region: PRK05582 879089003974 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 879089003975 active site 879089003976 interdomain interaction site; other site 879089003977 putative metal-binding site [ion binding]; other site 879089003978 nucleotide binding site [chemical binding]; other site 879089003979 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 879089003980 domain I; other site 879089003981 DNA binding groove [nucleotide binding] 879089003982 phosphate binding site [ion binding]; other site 879089003983 domain II; other site 879089003984 domain III; other site 879089003985 nucleotide binding site [chemical binding]; other site 879089003986 catalytic site [active] 879089003987 domain IV; other site 879089003988 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 879089003989 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 879089003990 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 879089003991 Glucose inhibited division protein A; Region: GIDA; pfam01134 879089003992 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 879089003993 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 879089003994 active site 879089003995 DNA binding site [nucleotide binding] 879089003996 Int/Topo IB signature motif; other site 879089003997 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 879089003998 active site 879089003999 HslU subunit interaction site [polypeptide binding]; other site 879089004000 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 879089004001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089004002 Walker A motif; other site 879089004003 ATP binding site [chemical binding]; other site 879089004004 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 879089004005 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 879089004006 transcriptional repressor CodY; Validated; Region: PRK04158 879089004007 CodY GAF-like domain; Region: CodY; pfam06018 879089004008 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 879089004009 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 879089004010 active site 879089004011 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 879089004012 active site 879089004013 catalytic residues [active] 879089004014 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 879089004015 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 879089004016 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 879089004017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089004018 Mg2+ binding site [ion binding]; other site 879089004019 G-X-G motif; other site 879089004020 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 879089004021 anchoring element; other site 879089004022 dimer interface [polypeptide binding]; other site 879089004023 ATP binding site [chemical binding]; other site 879089004024 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 879089004025 active site 879089004026 putative metal-binding site [ion binding]; other site 879089004027 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 879089004028 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 879089004029 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 879089004030 CAP-like domain; other site 879089004031 active site 879089004032 primary dimer interface [polypeptide binding]; other site 879089004033 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 879089004034 S-ribosylhomocysteinase; Provisional; Region: PRK02260 879089004035 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 879089004036 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089004037 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 879089004038 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 879089004039 catalytic triad [active] 879089004040 catalytic triad [active] 879089004041 oxyanion hole [active] 879089004042 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 879089004043 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 879089004044 active site 879089004045 catalytic site [active] 879089004046 metal binding site [ion binding]; metal-binding site 879089004047 dimer interface [polypeptide binding]; other site 879089004048 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 879089004049 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 879089004050 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 879089004051 bacterial Hfq-like; Region: Hfq; cd01716 879089004052 hexamer interface [polypeptide binding]; other site 879089004053 Sm1 motif; other site 879089004054 RNA binding site [nucleotide binding]; other site 879089004055 Sm2 motif; other site 879089004056 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 879089004057 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 879089004058 HflX GTPase family; Region: HflX; cd01878 879089004059 G1 box; other site 879089004060 GTP/Mg2+ binding site [chemical binding]; other site 879089004061 Switch I region; other site 879089004062 G2 box; other site 879089004063 G3 box; other site 879089004064 Switch II region; other site 879089004065 G4 box; other site 879089004066 G5 box; other site 879089004067 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 879089004068 Aluminium resistance protein; Region: Alum_res; pfam06838 879089004069 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 879089004070 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 879089004071 DNA binding residues [nucleotide binding] 879089004072 putative dimer interface [polypeptide binding]; other site 879089004073 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 879089004074 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 879089004075 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 879089004076 arsenical pump membrane protein; Provisional; Region: PRK15445 879089004077 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 879089004078 transmembrane helices; other site 879089004079 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 879089004080 LexA repressor; Validated; Region: PRK00215 879089004081 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 879089004082 putative DNA binding site [nucleotide binding]; other site 879089004083 putative Zn2+ binding site [ion binding]; other site 879089004084 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 879089004085 Catalytic site [active] 879089004086 cell division suppressor protein YneA; Provisional; Region: PRK14125 879089004087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 879089004088 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 879089004089 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 879089004090 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 879089004091 TPP-binding site [chemical binding]; other site 879089004092 dimer interface [polypeptide binding]; other site 879089004093 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 879089004094 PYR/PP interface [polypeptide binding]; other site 879089004095 dimer interface [polypeptide binding]; other site 879089004096 TPP binding site [chemical binding]; other site 879089004097 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 879089004098 hypothetical protein; Provisional; Region: PRK01844 879089004099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 879089004100 Methyltransferase domain; Region: Methyltransf_31; pfam13847 879089004101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089004102 S-adenosylmethionine binding site [chemical binding]; other site 879089004103 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 879089004104 ParB-like nuclease domain; Region: ParBc; pfam02195 879089004105 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 879089004106 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 879089004107 Active Sites [active] 879089004108 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 879089004109 DEAD-like helicases superfamily; Region: DEXDc; smart00487 879089004110 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 879089004111 putative nucleotide binding site [chemical binding]; other site 879089004112 uridine monophosphate binding site [chemical binding]; other site 879089004113 homohexameric interface [polypeptide binding]; other site 879089004114 ribosome recycling factor; Reviewed; Region: frr; PRK00083 879089004115 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 879089004116 hinge region; other site 879089004117 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 879089004118 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 879089004119 catalytic residue [active] 879089004120 putative FPP diphosphate binding site; other site 879089004121 putative FPP binding hydrophobic cleft; other site 879089004122 dimer interface [polypeptide binding]; other site 879089004123 putative IPP diphosphate binding site; other site 879089004124 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 879089004125 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 879089004126 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 879089004127 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 879089004128 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 879089004129 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 879089004130 RIP metalloprotease RseP; Region: TIGR00054 879089004131 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 879089004132 active site 879089004133 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 879089004134 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 879089004135 protein binding site [polypeptide binding]; other site 879089004136 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 879089004137 putative substrate binding region [chemical binding]; other site 879089004138 prolyl-tRNA synthetase; Provisional; Region: PRK09194 879089004139 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 879089004140 dimer interface [polypeptide binding]; other site 879089004141 motif 1; other site 879089004142 active site 879089004143 motif 2; other site 879089004144 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 879089004145 putative deacylase active site [active] 879089004146 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 879089004147 active site 879089004148 motif 3; other site 879089004149 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 879089004150 anticodon binding site; other site 879089004151 DNA polymerase III PolC; Validated; Region: polC; PRK00448 879089004152 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 879089004153 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 879089004154 generic binding surface II; other site 879089004155 generic binding surface I; other site 879089004156 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 879089004157 active site 879089004158 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 879089004159 active site 879089004160 catalytic site [active] 879089004161 substrate binding site [chemical binding]; other site 879089004162 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 879089004163 ribosome maturation protein RimP; Reviewed; Region: PRK00092 879089004164 Sm and related proteins; Region: Sm_like; cl00259 879089004165 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 879089004166 putative oligomer interface [polypeptide binding]; other site 879089004167 putative RNA binding site [nucleotide binding]; other site 879089004168 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 879089004169 NusA N-terminal domain; Region: NusA_N; pfam08529 879089004170 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 879089004171 RNA binding site [nucleotide binding]; other site 879089004172 homodimer interface [polypeptide binding]; other site 879089004173 NusA-like KH domain; Region: KH_5; pfam13184 879089004174 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 879089004175 G-X-X-G motif; other site 879089004176 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 879089004177 putative RNA binding cleft [nucleotide binding]; other site 879089004178 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 879089004179 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 879089004180 translation initiation factor IF-2; Region: IF-2; TIGR00487 879089004181 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 879089004182 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 879089004183 G1 box; other site 879089004184 putative GEF interaction site [polypeptide binding]; other site 879089004185 GTP/Mg2+ binding site [chemical binding]; other site 879089004186 Switch I region; other site 879089004187 G2 box; other site 879089004188 G3 box; other site 879089004189 Switch II region; other site 879089004190 G4 box; other site 879089004191 G5 box; other site 879089004192 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 879089004193 Translation-initiation factor 2; Region: IF-2; pfam11987 879089004194 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 879089004195 Protein of unknown function (DUF503); Region: DUF503; cl00669 879089004196 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 879089004197 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 879089004198 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 879089004199 RNA binding site [nucleotide binding]; other site 879089004200 active site 879089004201 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 879089004202 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 879089004203 active site 879089004204 Riboflavin kinase; Region: Flavokinase; smart00904 879089004205 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 879089004206 16S/18S rRNA binding site [nucleotide binding]; other site 879089004207 S13e-L30e interaction site [polypeptide binding]; other site 879089004208 25S rRNA binding site [nucleotide binding]; other site 879089004209 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 879089004210 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 879089004211 RNase E interface [polypeptide binding]; other site 879089004212 trimer interface [polypeptide binding]; other site 879089004213 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 879089004214 RNase E interface [polypeptide binding]; other site 879089004215 trimer interface [polypeptide binding]; other site 879089004216 active site 879089004217 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 879089004218 putative nucleic acid binding region [nucleotide binding]; other site 879089004219 G-X-X-G motif; other site 879089004220 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 879089004221 RNA binding site [nucleotide binding]; other site 879089004222 domain interface; other site 879089004223 GTPase RsgA; Reviewed; Region: PRK01889 879089004224 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 879089004225 RNA binding site [nucleotide binding]; other site 879089004226 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 879089004227 GTPase/Zn-binding domain interface [polypeptide binding]; other site 879089004228 GTP/Mg2+ binding site [chemical binding]; other site 879089004229 G4 box; other site 879089004230 G5 box; other site 879089004231 G1 box; other site 879089004232 Switch I region; other site 879089004233 G2 box; other site 879089004234 G3 box; other site 879089004235 Switch II region; other site 879089004236 YceG-like family; Region: YceG; pfam02618 879089004237 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 879089004238 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 879089004239 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 879089004240 Rhomboid family; Region: Rhomboid; pfam01694 879089004241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 879089004242 TPR motif; other site 879089004243 TPR repeat; Region: TPR_11; pfam13414 879089004244 binding surface 879089004245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 879089004246 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 879089004247 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 879089004248 nucleotide binding site [chemical binding]; other site 879089004249 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 879089004250 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 879089004251 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 879089004252 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 879089004253 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 879089004254 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 879089004255 Type II/IV secretion system protein; Region: T2SE; pfam00437 879089004256 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 879089004257 Walker A motif; other site 879089004258 ATP binding site [chemical binding]; other site 879089004259 Walker B motif; other site 879089004260 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 879089004261 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 879089004262 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 879089004263 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 879089004264 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 879089004265 tetramer interface [polypeptide binding]; other site 879089004266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089004267 catalytic residue [active] 879089004268 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 879089004269 tetramer interface [polypeptide binding]; other site 879089004270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089004271 catalytic residue [active] 879089004272 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 879089004273 active site residue [active] 879089004274 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 879089004275 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 879089004276 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 879089004277 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 879089004278 active site 879089004279 elongation factor P; Validated; Region: PRK00529 879089004280 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 879089004281 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 879089004282 RNA binding site [nucleotide binding]; other site 879089004283 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 879089004284 RNA binding site [nucleotide binding]; other site 879089004285 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 879089004286 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 879089004287 carboxyltransferase (CT) interaction site; other site 879089004288 biotinylation site [posttranslational modification]; other site 879089004289 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 879089004290 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 879089004291 ATP-grasp domain; Region: ATP-grasp_4; cl17255 879089004292 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 879089004293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 879089004294 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 879089004295 putative RNA binding site [nucleotide binding]; other site 879089004296 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 879089004297 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 879089004298 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 879089004299 homodimer interface [polypeptide binding]; other site 879089004300 NADP binding site [chemical binding]; other site 879089004301 substrate binding site [chemical binding]; other site 879089004302 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 879089004303 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 879089004304 generic binding surface II; other site 879089004305 generic binding surface I; other site 879089004306 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 879089004307 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 879089004308 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 879089004309 substrate binding pocket [chemical binding]; other site 879089004310 chain length determination region; other site 879089004311 substrate-Mg2+ binding site; other site 879089004312 catalytic residues [active] 879089004313 aspartate-rich region 1; other site 879089004314 active site lid residues [active] 879089004315 aspartate-rich region 2; other site 879089004316 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 879089004317 DNA-binding site [nucleotide binding]; DNA binding site 879089004318 RNA-binding motif; other site 879089004319 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 879089004320 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 879089004321 TPP-binding site; other site 879089004322 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 879089004323 PYR/PP interface [polypeptide binding]; other site 879089004324 dimer interface [polypeptide binding]; other site 879089004325 TPP binding site [chemical binding]; other site 879089004326 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 879089004327 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 879089004328 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 879089004329 RNA binding surface [nucleotide binding]; other site 879089004330 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 879089004331 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 879089004332 arginine repressor; Provisional; Region: PRK04280 879089004333 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 879089004334 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 879089004335 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 879089004336 Walker A/P-loop; other site 879089004337 ATP binding site [chemical binding]; other site 879089004338 Q-loop/lid; other site 879089004339 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 879089004340 ABC transporter signature motif; other site 879089004341 Walker B; other site 879089004342 D-loop; other site 879089004343 H-loop/switch region; other site 879089004344 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 879089004345 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 879089004346 nucleotide binding site [chemical binding]; other site 879089004347 Acetokinase family; Region: Acetate_kinase; cl17229 879089004348 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 879089004349 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 879089004350 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 879089004351 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 879089004352 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 879089004353 tetramer interface [polypeptide binding]; other site 879089004354 TPP-binding site [chemical binding]; other site 879089004355 heterodimer interface [polypeptide binding]; other site 879089004356 phosphorylation loop region [posttranslational modification] 879089004357 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 879089004358 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 879089004359 alpha subunit interface [polypeptide binding]; other site 879089004360 TPP binding site [chemical binding]; other site 879089004361 heterodimer interface [polypeptide binding]; other site 879089004362 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 879089004363 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 879089004364 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 879089004365 E3 interaction surface; other site 879089004366 lipoyl attachment site [posttranslational modification]; other site 879089004367 e3 binding domain; Region: E3_binding; pfam02817 879089004368 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 879089004369 peptidase T-like protein; Region: PepT-like; TIGR01883 879089004370 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 879089004371 metal binding site [ion binding]; metal-binding site 879089004372 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 879089004373 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 879089004374 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 879089004375 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 879089004376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089004377 active site 879089004378 phosphorylation site [posttranslational modification] 879089004379 intermolecular recognition site; other site 879089004380 dimerization interface [polypeptide binding]; other site 879089004381 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 879089004382 DNA binding site [nucleotide binding] 879089004383 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 879089004384 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 879089004385 dimerization interface [polypeptide binding]; other site 879089004386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 879089004387 dimer interface [polypeptide binding]; other site 879089004388 phosphorylation site [posttranslational modification] 879089004389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089004390 ATP binding site [chemical binding]; other site 879089004391 Mg2+ binding site [ion binding]; other site 879089004392 G-X-G motif; other site 879089004393 OxaA-like protein precursor; Validated; Region: PRK01622 879089004394 acylphosphatase; Provisional; Region: PRK14443 879089004395 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 879089004396 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 879089004397 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 879089004398 homotetramer interface [polypeptide binding]; other site 879089004399 FMN binding site [chemical binding]; other site 879089004400 homodimer contacts [polypeptide binding]; other site 879089004401 putative active site [active] 879089004402 putative substrate binding site [chemical binding]; other site 879089004403 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 879089004404 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 879089004405 active site residue [active] 879089004406 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 879089004407 Uncharacterized conserved protein [Function unknown]; Region: COG1284 879089004408 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 879089004409 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 879089004410 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 879089004411 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 879089004412 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 879089004413 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 879089004414 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 879089004415 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 879089004416 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 879089004417 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 879089004418 ligand binding site [chemical binding]; other site 879089004419 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 879089004420 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 879089004421 Walker A/P-loop; other site 879089004422 ATP binding site [chemical binding]; other site 879089004423 Q-loop/lid; other site 879089004424 ABC transporter signature motif; other site 879089004425 Walker B; other site 879089004426 D-loop; other site 879089004427 H-loop/switch region; other site 879089004428 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 879089004429 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 879089004430 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 879089004431 TM-ABC transporter signature motif; other site 879089004432 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 879089004433 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 879089004434 TM-ABC transporter signature motif; other site 879089004435 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 879089004436 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 879089004437 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 879089004438 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 879089004439 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 879089004440 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 879089004441 classical (c) SDRs; Region: SDR_c; cd05233 879089004442 NAD(P) binding site [chemical binding]; other site 879089004443 active site 879089004444 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 879089004445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089004446 non-specific DNA binding site [nucleotide binding]; other site 879089004447 salt bridge; other site 879089004448 sequence-specific DNA binding site [nucleotide binding]; other site 879089004449 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 879089004450 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 879089004451 competence damage-inducible protein A; Provisional; Region: PRK00549 879089004452 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 879089004453 putative MPT binding site; other site 879089004454 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 879089004455 recombinase A; Provisional; Region: recA; PRK09354 879089004456 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 879089004457 hexamer interface [polypeptide binding]; other site 879089004458 Walker A motif; other site 879089004459 ATP binding site [chemical binding]; other site 879089004460 Walker B motif; other site 879089004461 phosphodiesterase; Provisional; Region: PRK12704 879089004462 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 879089004463 Zn2+ binding site [ion binding]; other site 879089004464 Mg2+ binding site [ion binding]; other site 879089004465 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 879089004466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089004467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 879089004468 Coenzyme A binding pocket [chemical binding]; other site 879089004469 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 879089004470 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 879089004471 putative active site [active] 879089004472 metal binding site [ion binding]; metal-binding site 879089004473 homodimer binding site [polypeptide binding]; other site 879089004474 Predicted membrane protein [Function unknown]; Region: COG4550 879089004475 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 879089004476 MutS domain I; Region: MutS_I; pfam01624 879089004477 MutS domain II; Region: MutS_II; pfam05188 879089004478 MutS domain III; Region: MutS_III; pfam05192 879089004479 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 879089004480 Walker A/P-loop; other site 879089004481 ATP binding site [chemical binding]; other site 879089004482 Q-loop/lid; other site 879089004483 ABC transporter signature motif; other site 879089004484 Walker B; other site 879089004485 D-loop; other site 879089004486 H-loop/switch region; other site 879089004487 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 879089004488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089004489 ATP binding site [chemical binding]; other site 879089004490 Mg2+ binding site [ion binding]; other site 879089004491 G-X-G motif; other site 879089004492 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 879089004493 ATP binding site [chemical binding]; other site 879089004494 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 879089004495 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 879089004496 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 879089004497 Pyruvate formate lyase 1; Region: PFL1; cd01678 879089004498 coenzyme A binding site [chemical binding]; other site 879089004499 active site 879089004500 catalytic residues [active] 879089004501 glycine loop; other site 879089004502 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 879089004503 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 879089004504 FeS/SAM binding site; other site 879089004505 Predicted transcriptional regulators [Transcription]; Region: COG1695 879089004506 Transcriptional regulator PadR-like family; Region: PadR; cl17335 879089004507 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 879089004508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089004509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 879089004510 putative substrate translocation pore; other site 879089004511 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089004512 non-specific DNA binding site [nucleotide binding]; other site 879089004513 salt bridge; other site 879089004514 sequence-specific DNA binding site [nucleotide binding]; other site 879089004515 AAA domain; Region: AAA_17; pfam13207 879089004516 topology modulation protein; Reviewed; Region: PRK08118 879089004517 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 879089004518 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 879089004519 active site 879089004520 DNA binding site [nucleotide binding] 879089004521 Int/Topo IB signature motif; other site 879089004522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089004523 non-specific DNA binding site [nucleotide binding]; other site 879089004524 salt bridge; other site 879089004525 sequence-specific DNA binding site [nucleotide binding]; other site 879089004526 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 879089004527 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 879089004528 Peptidase family M23; Region: Peptidase_M23; pfam01551 879089004529 Domain of unknown function (DUF1874); Region: DUF1874; cl07531 879089004530 AAA-like domain; Region: AAA_10; pfam12846 879089004531 TcpE family; Region: TcpE; pfam12648 879089004532 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 879089004533 Cna protein B-type domain; Region: Cna_B; pfam05738 879089004534 Cna protein B-type domain; Region: Cna_B; pfam05738 879089004535 Cna protein B-type domain; Region: Cna_B; pfam05738 879089004536 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089004537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 879089004538 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 879089004539 Replication initiation factor; Region: Rep_trans; pfam02486 879089004540 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 879089004541 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 879089004542 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 879089004543 Antirestriction protein (ArdA); Region: ArdA; cl01953 879089004544 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089004545 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089004546 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089004547 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089004548 putative acyltransferase; Provisional; Region: PRK05790 879089004549 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 879089004550 dimer interface [polypeptide binding]; other site 879089004551 active site 879089004552 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 879089004553 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 879089004554 dimer interface [polypeptide binding]; other site 879089004555 active site 879089004556 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 879089004557 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 879089004558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089004559 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 879089004560 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 879089004561 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 879089004562 Domain of unknown function DUF20; Region: UPF0118; pfam01594 879089004563 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 879089004564 FAD binding domain; Region: FAD_binding_4; pfam01565 879089004565 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 879089004566 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 879089004567 Walker A/P-loop; other site 879089004568 ATP binding site [chemical binding]; other site 879089004569 Q-loop/lid; other site 879089004570 ABC transporter signature motif; other site 879089004571 Walker B; other site 879089004572 D-loop; other site 879089004573 H-loop/switch region; other site 879089004574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089004575 dimer interface [polypeptide binding]; other site 879089004576 conserved gate region; other site 879089004577 ABC-ATPase subunit interface; other site 879089004578 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 879089004579 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 879089004580 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 879089004581 manganese transport protein MntH; Reviewed; Region: PRK00701 879089004582 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 879089004583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089004584 dimer interface [polypeptide binding]; other site 879089004585 conserved gate region; other site 879089004586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 879089004587 ABC-ATPase subunit interface; other site 879089004588 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 879089004589 LysR substrate binding domain; Region: LysR_substrate; pfam03466 879089004590 dimerization interface [polypeptide binding]; other site 879089004591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089004592 dimer interface [polypeptide binding]; other site 879089004593 conserved gate region; other site 879089004594 putative PBP binding loops; other site 879089004595 ABC-ATPase subunit interface; other site 879089004596 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 879089004597 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 879089004598 Walker A/P-loop; other site 879089004599 ATP binding site [chemical binding]; other site 879089004600 Q-loop/lid; other site 879089004601 ABC transporter signature motif; other site 879089004602 Walker B; other site 879089004603 D-loop; other site 879089004604 H-loop/switch region; other site 879089004605 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 879089004606 Predicted membrane protein [Function unknown]; Region: COG3859 879089004607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 879089004608 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 879089004609 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 879089004610 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 879089004611 ABC transporter; Region: ABC_tran_2; pfam12848 879089004612 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 879089004613 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 879089004614 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 879089004615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 879089004616 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 879089004617 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 879089004618 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 879089004619 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 879089004620 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 879089004621 dihydrodipicolinate synthase; Region: dapA; TIGR00674 879089004622 dimer interface [polypeptide binding]; other site 879089004623 active site 879089004624 catalytic residue [active] 879089004625 aspartate kinase I; Reviewed; Region: PRK08210 879089004626 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 879089004627 nucleotide binding site [chemical binding]; other site 879089004628 substrate binding site [chemical binding]; other site 879089004629 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 879089004630 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 879089004631 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 879089004632 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 879089004633 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 879089004634 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 879089004635 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 879089004636 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 879089004637 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 879089004638 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 879089004639 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 879089004640 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 879089004641 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 879089004642 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 879089004643 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 879089004644 Predicted membrane protein [Function unknown]; Region: COG4392 879089004645 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 879089004646 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 879089004647 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 879089004648 metal binding site 2 [ion binding]; metal-binding site 879089004649 putative DNA binding helix; other site 879089004650 metal binding site 1 [ion binding]; metal-binding site 879089004651 dimer interface [polypeptide binding]; other site 879089004652 structural Zn2+ binding site [ion binding]; other site 879089004653 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 879089004654 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 879089004655 ABC-ATPase subunit interface; other site 879089004656 dimer interface [polypeptide binding]; other site 879089004657 putative PBP binding regions; other site 879089004658 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 879089004659 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 879089004660 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 879089004661 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 879089004662 DHHA2 domain; Region: DHHA2; pfam02833 879089004663 endonuclease IV; Provisional; Region: PRK01060 879089004664 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 879089004665 AP (apurinic/apyrimidinic) site pocket; other site 879089004666 DNA interaction; other site 879089004667 Metal-binding active site; metal-binding site 879089004668 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 879089004669 DEAD-like helicases superfamily; Region: DEXDc; smart00487 879089004670 ATP binding site [chemical binding]; other site 879089004671 Mg++ binding site [ion binding]; other site 879089004672 motif III; other site 879089004673 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 879089004674 nucleotide binding region [chemical binding]; other site 879089004675 ATP-binding site [chemical binding]; other site 879089004676 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 879089004677 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 879089004678 Uncharacterized conserved protein [Function unknown]; Region: COG0327 879089004679 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 879089004680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 879089004681 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 879089004682 Uncharacterized conserved protein [Function unknown]; Region: COG0327 879089004683 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 879089004684 Family of unknown function (DUF633); Region: DUF633; pfam04816 879089004685 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 879089004686 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 879089004687 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 879089004688 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 879089004689 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 879089004690 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 879089004691 DNA binding residues [nucleotide binding] 879089004692 DNA primase; Validated; Region: dnaG; PRK05667 879089004693 CHC2 zinc finger; Region: zf-CHC2; pfam01807 879089004694 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 879089004695 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 879089004696 active site 879089004697 metal binding site [ion binding]; metal-binding site 879089004698 interdomain interaction site; other site 879089004699 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 879089004700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 879089004701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 879089004702 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 879089004703 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 879089004704 DALR anticodon binding domain; Region: DALR_1; pfam05746 879089004705 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 879089004706 dimer interface [polypeptide binding]; other site 879089004707 motif 1; other site 879089004708 active site 879089004709 motif 2; other site 879089004710 motif 3; other site 879089004711 DNA repair protein RecO; Region: reco; TIGR00613 879089004712 Recombination protein O N terminal; Region: RecO_N; pfam11967 879089004713 Recombination protein O C terminal; Region: RecO_C; pfam02565 879089004714 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 879089004715 GTPase Era; Reviewed; Region: era; PRK00089 879089004716 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 879089004717 G1 box; other site 879089004718 GTP/Mg2+ binding site [chemical binding]; other site 879089004719 Switch I region; other site 879089004720 G2 box; other site 879089004721 Switch II region; other site 879089004722 G3 box; other site 879089004723 G4 box; other site 879089004724 G5 box; other site 879089004725 KH domain; Region: KH_2; pfam07650 879089004726 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 879089004727 active site 879089004728 catalytic motif [active] 879089004729 Zn binding site [ion binding]; other site 879089004730 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 879089004731 metal-binding heat shock protein; Provisional; Region: PRK00016 879089004732 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 879089004733 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 879089004734 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 879089004735 Zn2+ binding site [ion binding]; other site 879089004736 Mg2+ binding site [ion binding]; other site 879089004737 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 879089004738 PhoH-like protein; Region: PhoH; pfam02562 879089004739 Yqey-like protein; Region: YqeY; pfam09424 879089004740 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 879089004741 RNA methyltransferase, RsmE family; Region: TIGR00046 879089004742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 879089004743 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 879089004744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089004745 S-adenosylmethionine binding site [chemical binding]; other site 879089004746 chaperone protein DnaJ; Provisional; Region: PRK14280 879089004747 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 879089004748 HSP70 interaction site [polypeptide binding]; other site 879089004749 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 879089004750 substrate binding site [polypeptide binding]; other site 879089004751 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 879089004752 Zn binding sites [ion binding]; other site 879089004753 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 879089004754 dimer interface [polypeptide binding]; other site 879089004755 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 879089004756 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 879089004757 nucleotide binding site [chemical binding]; other site 879089004758 NEF interaction site [polypeptide binding]; other site 879089004759 SBD interface [polypeptide binding]; other site 879089004760 heat shock protein GrpE; Provisional; Region: PRK14140 879089004761 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 879089004762 dimer interface [polypeptide binding]; other site 879089004763 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 879089004764 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 879089004765 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 879089004766 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 879089004767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 879089004768 FeS/SAM binding site; other site 879089004769 HemN C-terminal domain; Region: HemN_C; pfam06969 879089004770 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 879089004771 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 879089004772 NADP binding site [chemical binding]; other site 879089004773 putative substrate binding site [chemical binding]; other site 879089004774 active site 879089004775 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 879089004776 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 879089004777 DNA binding residues [nucleotide binding] 879089004778 putative dimer interface [polypeptide binding]; other site 879089004779 GTP-binding protein LepA; Provisional; Region: PRK05433 879089004780 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 879089004781 G1 box; other site 879089004782 putative GEF interaction site [polypeptide binding]; other site 879089004783 GTP/Mg2+ binding site [chemical binding]; other site 879089004784 Switch I region; other site 879089004785 G2 box; other site 879089004786 G3 box; other site 879089004787 Switch II region; other site 879089004788 G4 box; other site 879089004789 G5 box; other site 879089004790 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 879089004791 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 879089004792 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 879089004793 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 879089004794 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 879089004795 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 879089004796 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 879089004797 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 879089004798 Competence protein; Region: Competence; pfam03772 879089004799 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 879089004800 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 879089004801 catalytic motif [active] 879089004802 Zn binding site [ion binding]; other site 879089004803 SLBB domain; Region: SLBB; pfam10531 879089004804 comEA protein; Region: comE; TIGR01259 879089004805 Helix-hairpin-helix motif; Region: HHH; pfam00633 879089004806 Methyltransferase domain; Region: Methyltransf_23; pfam13489 879089004807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089004808 S-adenosylmethionine binding site [chemical binding]; other site 879089004809 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 879089004810 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 879089004811 Zn2+ binding site [ion binding]; other site 879089004812 Mg2+ binding site [ion binding]; other site 879089004813 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 879089004814 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 879089004815 active site 879089004816 (T/H)XGH motif; other site 879089004817 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 879089004818 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 879089004819 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 879089004820 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 879089004821 shikimate binding site; other site 879089004822 NAD(P) binding site [chemical binding]; other site 879089004823 GTPase YqeH; Provisional; Region: PRK13796 879089004824 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 879089004825 GTP/Mg2+ binding site [chemical binding]; other site 879089004826 G4 box; other site 879089004827 G5 box; other site 879089004828 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 879089004829 G1 box; other site 879089004830 G1 box; other site 879089004831 GTP/Mg2+ binding site [chemical binding]; other site 879089004832 G2 box; other site 879089004833 Switch I region; other site 879089004834 G2 box; other site 879089004835 Switch I region; other site 879089004836 G3 box; other site 879089004837 G3 box; other site 879089004838 Switch II region; other site 879089004839 Switch II region; other site 879089004840 G4 box; other site 879089004841 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 879089004842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089004843 motif II; other site 879089004844 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 879089004845 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 879089004846 active site 879089004847 Zn binding site [ion binding]; other site 879089004848 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 879089004849 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 879089004850 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 879089004851 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 879089004852 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 879089004853 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 879089004854 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 879089004855 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 879089004856 Sugar specificity; other site 879089004857 Pyrimidine base specificity; other site 879089004858 ATP-binding site [chemical binding]; other site 879089004859 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 879089004860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089004861 S-adenosylmethionine binding site [chemical binding]; other site 879089004862 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 879089004863 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 879089004864 dimerization interface [polypeptide binding]; other site 879089004865 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 879089004866 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 879089004867 hypothetical protein; Provisional; Region: PRK13678 879089004868 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 879089004869 hypothetical protein; Provisional; Region: PRK05473 879089004870 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 879089004871 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 879089004872 motif 1; other site 879089004873 active site 879089004874 motif 2; other site 879089004875 motif 3; other site 879089004876 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 879089004877 DHHA1 domain; Region: DHHA1; pfam02272 879089004878 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 879089004879 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 879089004880 Walker A/P-loop; other site 879089004881 ATP binding site [chemical binding]; other site 879089004882 Q-loop/lid; other site 879089004883 ABC transporter signature motif; other site 879089004884 Walker B; other site 879089004885 D-loop; other site 879089004886 H-loop/switch region; other site 879089004887 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 879089004888 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 879089004889 FtsX-like permease family; Region: FtsX; pfam02687 879089004890 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 879089004891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089004892 active site 879089004893 phosphorylation site [posttranslational modification] 879089004894 intermolecular recognition site; other site 879089004895 dimerization interface [polypeptide binding]; other site 879089004896 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 879089004897 DNA binding site [nucleotide binding] 879089004898 sensor kinase CusS; Provisional; Region: PRK09835 879089004899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 879089004900 dimerization interface [polypeptide binding]; other site 879089004901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 879089004902 dimer interface [polypeptide binding]; other site 879089004903 phosphorylation site [posttranslational modification] 879089004904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089004905 ATP binding site [chemical binding]; other site 879089004906 Mg2+ binding site [ion binding]; other site 879089004907 G-X-G motif; other site 879089004908 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 879089004909 AAA domain; Region: AAA_30; pfam13604 879089004910 Family description; Region: UvrD_C_2; pfam13538 879089004911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 879089004912 binding surface 879089004913 TPR motif; other site 879089004914 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 879089004915 TPR repeat; Region: TPR_11; pfam13414 879089004916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 879089004917 binding surface 879089004918 TPR motif; other site 879089004919 TPR repeat; Region: TPR_11; pfam13414 879089004920 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 879089004921 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 879089004922 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 879089004923 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 879089004924 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 879089004925 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 879089004926 catalytic residue [active] 879089004927 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 879089004928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089004929 Walker A motif; other site 879089004930 ATP binding site [chemical binding]; other site 879089004931 Walker B motif; other site 879089004932 arginine finger; other site 879089004933 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 879089004934 Predicted transcriptional regulator [Transcription]; Region: COG1959 879089004935 Transcriptional regulator; Region: Rrf2; pfam02082 879089004936 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 879089004937 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 879089004938 Nitrogen regulatory protein P-II; Region: P-II; smart00938 879089004939 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 879089004940 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 879089004941 dimer interface [polypeptide binding]; other site 879089004942 anticodon binding site; other site 879089004943 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 879089004944 homodimer interface [polypeptide binding]; other site 879089004945 motif 1; other site 879089004946 active site 879089004947 motif 2; other site 879089004948 GAD domain; Region: GAD; pfam02938 879089004949 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 879089004950 motif 3; other site 879089004951 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 879089004952 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 879089004953 dimer interface [polypeptide binding]; other site 879089004954 motif 1; other site 879089004955 active site 879089004956 motif 2; other site 879089004957 motif 3; other site 879089004958 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 879089004959 anticodon binding site; other site 879089004960 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 879089004961 Bacterial SH3 domain; Region: SH3_3; pfam08239 879089004962 Bacterial SH3 domain; Region: SH3_3; pfam08239 879089004963 Bacterial SH3 domain homologues; Region: SH3b; smart00287 879089004964 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 879089004965 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 879089004966 active site 879089004967 metal binding site [ion binding]; metal-binding site 879089004968 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 879089004969 putative active site [active] 879089004970 dimerization interface [polypeptide binding]; other site 879089004971 putative tRNAtyr binding site [nucleotide binding]; other site 879089004972 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 879089004973 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 879089004974 Zn2+ binding site [ion binding]; other site 879089004975 Mg2+ binding site [ion binding]; other site 879089004976 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 879089004977 synthetase active site [active] 879089004978 NTP binding site [chemical binding]; other site 879089004979 metal binding site [ion binding]; metal-binding site 879089004980 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 879089004981 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 879089004982 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 879089004983 active site 879089004984 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 879089004985 DHH family; Region: DHH; pfam01368 879089004986 DHHA1 domain; Region: DHHA1; pfam02272 879089004987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 879089004988 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 879089004989 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 879089004990 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 879089004991 Protein export membrane protein; Region: SecD_SecF; cl14618 879089004992 Protein export membrane protein; Region: SecD_SecF; pfam02355 879089004993 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 879089004994 Preprotein translocase subunit; Region: YajC; pfam02699 879089004995 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 879089004996 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 879089004997 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 879089004998 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 879089004999 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 879089005000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089005001 Walker A motif; other site 879089005002 ATP binding site [chemical binding]; other site 879089005003 Walker B motif; other site 879089005004 arginine finger; other site 879089005005 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 879089005006 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 879089005007 RuvA N terminal domain; Region: RuvA_N; pfam01330 879089005008 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 879089005009 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 879089005010 tetramer (dimer of dimers) interface [polypeptide binding]; other site 879089005011 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 879089005012 NAD binding site [chemical binding]; other site 879089005013 dimer interface [polypeptide binding]; other site 879089005014 substrate binding site [chemical binding]; other site 879089005015 hypothetical protein; Validated; Region: PRK00110 879089005016 prephenate dehydratase; Provisional; Region: PRK11898 879089005017 Prephenate dehydratase; Region: PDT; pfam00800 879089005018 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 879089005019 putative L-Phe binding site [chemical binding]; other site 879089005020 GTPase CgtA; Reviewed; Region: obgE; PRK12297 879089005021 GTP1/OBG; Region: GTP1_OBG; pfam01018 879089005022 Obg GTPase; Region: Obg; cd01898 879089005023 G1 box; other site 879089005024 GTP/Mg2+ binding site [chemical binding]; other site 879089005025 Switch I region; other site 879089005026 G2 box; other site 879089005027 G3 box; other site 879089005028 Switch II region; other site 879089005029 G4 box; other site 879089005030 G5 box; other site 879089005031 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 879089005032 glycerol kinase; Provisional; Region: glpK; PRK00047 879089005033 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 879089005034 N- and C-terminal domain interface [polypeptide binding]; other site 879089005035 active site 879089005036 MgATP binding site [chemical binding]; other site 879089005037 catalytic site [active] 879089005038 metal binding site [ion binding]; metal-binding site 879089005039 glycerol binding site [chemical binding]; other site 879089005040 homotetramer interface [polypeptide binding]; other site 879089005041 homodimer interface [polypeptide binding]; other site 879089005042 FBP binding site [chemical binding]; other site 879089005043 protein IIAGlc interface [polypeptide binding]; other site 879089005044 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 879089005045 amphipathic channel; other site 879089005046 Asn-Pro-Ala signature motifs; other site 879089005047 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 879089005048 hypothetical protein; Provisional; Region: PRK14553 879089005049 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 879089005050 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 879089005051 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 879089005052 homodimer interface [polypeptide binding]; other site 879089005053 oligonucleotide binding site [chemical binding]; other site 879089005054 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 879089005055 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 879089005056 Switch I; other site 879089005057 Switch II; other site 879089005058 septum formation inhibitor; Reviewed; Region: minC; PRK00513 879089005059 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 879089005060 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 879089005061 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 879089005062 Protein of unknown function (DUF972); Region: DUF972; pfam06156 879089005063 rod shape-determining protein MreC; Region: MreC; pfam04085 879089005064 rod shape-determining protein MreB; Provisional; Region: PRK13927 879089005065 MreB and similar proteins; Region: MreB_like; cd10225 879089005066 nucleotide binding site [chemical binding]; other site 879089005067 Mg binding site [ion binding]; other site 879089005068 putative protofilament interaction site [polypeptide binding]; other site 879089005069 RodZ interaction site [polypeptide binding]; other site 879089005070 hypothetical protein; Reviewed; Region: PRK00024 879089005071 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 879089005072 MPN+ (JAMM) motif; other site 879089005073 Zinc-binding site [ion binding]; other site 879089005074 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 879089005075 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 879089005076 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 879089005077 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 879089005078 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 879089005079 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 879089005080 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 879089005081 active site 879089005082 HIGH motif; other site 879089005083 nucleotide binding site [chemical binding]; other site 879089005084 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 879089005085 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 879089005086 active site 879089005087 KMSKS motif; other site 879089005088 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 879089005089 tRNA binding surface [nucleotide binding]; other site 879089005090 anticodon binding site; other site 879089005091 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 879089005092 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 879089005093 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 879089005094 inhibitor-cofactor binding pocket; inhibition site 879089005095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089005096 catalytic residue [active] 879089005097 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 879089005098 dimer interface [polypeptide binding]; other site 879089005099 active site 879089005100 Schiff base residues; other site 879089005101 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 879089005102 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 879089005103 active site 879089005104 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 879089005105 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 879089005106 domain interfaces; other site 879089005107 active site 879089005108 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 879089005109 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 879089005110 tRNA; other site 879089005111 putative tRNA binding site [nucleotide binding]; other site 879089005112 putative NADP binding site [chemical binding]; other site 879089005113 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 879089005114 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 879089005115 G1 box; other site 879089005116 GTP/Mg2+ binding site [chemical binding]; other site 879089005117 Switch I region; other site 879089005118 G2 box; other site 879089005119 G3 box; other site 879089005120 Switch II region; other site 879089005121 G4 box; other site 879089005122 G5 box; other site 879089005123 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 879089005124 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 879089005125 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 879089005126 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 879089005127 active site 879089005128 dimer interface [polypeptide binding]; other site 879089005129 motif 1; other site 879089005130 motif 2; other site 879089005131 motif 3; other site 879089005132 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 879089005133 anticodon binding site; other site 879089005134 primosomal protein DnaI; Reviewed; Region: PRK08939 879089005135 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 879089005136 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 879089005137 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 879089005138 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 879089005139 ATP cone domain; Region: ATP-cone; pfam03477 879089005140 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 879089005141 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 879089005142 CoA-binding site [chemical binding]; other site 879089005143 ATP-binding [chemical binding]; other site 879089005144 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 879089005145 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 879089005146 DNA binding site [nucleotide binding] 879089005147 catalytic residue [active] 879089005148 H2TH interface [polypeptide binding]; other site 879089005149 putative catalytic residues [active] 879089005150 turnover-facilitating residue; other site 879089005151 intercalation triad [nucleotide binding]; other site 879089005152 8OG recognition residue [nucleotide binding]; other site 879089005153 putative reading head residues; other site 879089005154 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 879089005155 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 879089005156 DNA polymerase I; Provisional; Region: PRK05755 879089005157 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 879089005158 active site 879089005159 metal binding site 1 [ion binding]; metal-binding site 879089005160 putative 5' ssDNA interaction site; other site 879089005161 metal binding site 3; metal-binding site 879089005162 metal binding site 2 [ion binding]; metal-binding site 879089005163 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 879089005164 putative DNA binding site [nucleotide binding]; other site 879089005165 putative metal binding site [ion binding]; other site 879089005166 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 879089005167 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 879089005168 active site 879089005169 DNA binding site [nucleotide binding] 879089005170 catalytic site [active] 879089005171 isocitrate dehydrogenase; Reviewed; Region: PRK07006 879089005172 isocitrate dehydrogenase; Validated; Region: PRK07362 879089005173 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 879089005174 dimer interface [polypeptide binding]; other site 879089005175 Citrate synthase; Region: Citrate_synt; pfam00285 879089005176 active site 879089005177 citrylCoA binding site [chemical binding]; other site 879089005178 oxalacetate/citrate binding site [chemical binding]; other site 879089005179 coenzyme A binding site [chemical binding]; other site 879089005180 catalytic triad [active] 879089005181 Protein of unknown function (DUF441); Region: DUF441; pfam04284 879089005182 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 879089005183 pyruvate kinase; Provisional; Region: PRK06354 879089005184 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 879089005185 domain interfaces; other site 879089005186 active site 879089005187 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 879089005188 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 879089005189 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 879089005190 active site 879089005191 ADP/pyrophosphate binding site [chemical binding]; other site 879089005192 dimerization interface [polypeptide binding]; other site 879089005193 allosteric effector site; other site 879089005194 fructose-1,6-bisphosphate binding site; other site 879089005195 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 879089005196 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 879089005197 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 879089005198 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 879089005199 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 879089005200 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 879089005201 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 879089005202 active site 879089005203 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 879089005204 generic binding surface I; other site 879089005205 generic binding surface II; other site 879089005206 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 879089005207 DHH family; Region: DHH; pfam01368 879089005208 DHHA1 domain; Region: DHHA1; pfam02272 879089005209 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 879089005210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 879089005211 DNA-binding site [nucleotide binding]; DNA binding site 879089005212 DRTGG domain; Region: DRTGG; pfam07085 879089005213 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 879089005214 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 879089005215 active site 2 [active] 879089005216 active site 1 [active] 879089005217 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 879089005218 metal-dependent hydrolase; Provisional; Region: PRK00685 879089005219 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 879089005220 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 879089005221 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 879089005222 active site 879089005223 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 879089005224 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 879089005225 hexamer interface [polypeptide binding]; other site 879089005226 ligand binding site [chemical binding]; other site 879089005227 putative active site [active] 879089005228 NAD(P) binding site [chemical binding]; other site 879089005229 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 879089005230 Ligand Binding Site [chemical binding]; other site 879089005231 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 879089005232 propionate/acetate kinase; Provisional; Region: PRK12379 879089005233 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 879089005234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089005235 S-adenosylmethionine binding site [chemical binding]; other site 879089005236 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 879089005237 dimer interface [polypeptide binding]; other site 879089005238 catalytic triad [active] 879089005239 peroxidatic and resolving cysteines [active] 879089005240 RDD family; Region: RDD; pfam06271 879089005241 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 879089005242 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 879089005243 tandem repeat interface [polypeptide binding]; other site 879089005244 oligomer interface [polypeptide binding]; other site 879089005245 active site residues [active] 879089005246 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 879089005247 ATP-NAD kinase; Region: NAD_kinase; pfam01513 879089005248 ornithine carbamoyltransferase; Provisional; Region: PRK00779 879089005249 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 879089005250 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 879089005251 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 879089005252 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 879089005253 inhibitor-cofactor binding pocket; inhibition site 879089005254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089005255 catalytic residue [active] 879089005256 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 879089005257 nucleotide binding site [chemical binding]; other site 879089005258 N-acetyl-L-glutamate binding site [chemical binding]; other site 879089005259 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 879089005260 heterotetramer interface [polypeptide binding]; other site 879089005261 active site pocket [active] 879089005262 cleavage site 879089005263 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 879089005264 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 879089005265 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 879089005266 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 879089005267 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 879089005268 Ligand Binding Site [chemical binding]; other site 879089005269 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 879089005270 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 879089005271 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 879089005272 catalytic residue [active] 879089005273 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 879089005274 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 879089005275 GAF domain; Region: GAF_2; pfam13185 879089005276 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 879089005277 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 879089005278 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 879089005279 RNA binding surface [nucleotide binding]; other site 879089005280 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 879089005281 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 879089005282 active site 879089005283 HIGH motif; other site 879089005284 dimer interface [polypeptide binding]; other site 879089005285 KMSKS motif; other site 879089005286 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 879089005287 RNA binding surface [nucleotide binding]; other site 879089005288 catabolite control protein A; Region: ccpA; TIGR01481 879089005289 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 879089005290 DNA binding site [nucleotide binding] 879089005291 domain linker motif; other site 879089005292 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 879089005293 dimerization interface [polypeptide binding]; other site 879089005294 effector binding site; other site 879089005295 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 879089005296 Chorismate mutase type II; Region: CM_2; cl00693 879089005297 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 879089005298 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 879089005299 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 879089005300 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 879089005301 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 879089005302 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 879089005303 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 879089005304 dimer interface [polypeptide binding]; other site 879089005305 decamer (pentamer of dimers) interface [polypeptide binding]; other site 879089005306 catalytic triad [active] 879089005307 peroxidatic and resolving cysteines [active] 879089005308 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 879089005309 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 879089005310 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 879089005311 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 879089005312 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 879089005313 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 879089005314 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 879089005315 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 879089005316 putative tRNA-binding site [nucleotide binding]; other site 879089005317 hypothetical protein; Provisional; Region: PRK13668 879089005318 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 879089005319 catalytic residues [active] 879089005320 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 879089005321 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 879089005322 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 879089005323 oligomer interface [polypeptide binding]; other site 879089005324 active site 879089005325 metal binding site [ion binding]; metal-binding site 879089005326 Predicted small secreted protein [Function unknown]; Region: COG5584 879089005327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 879089005328 putative homodimer interface [polypeptide binding]; other site 879089005329 putative homotetramer interface [polypeptide binding]; other site 879089005330 putative allosteric switch controlling residues; other site 879089005331 putative metal binding site [ion binding]; other site 879089005332 putative homodimer-homodimer interface [polypeptide binding]; other site 879089005333 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 879089005334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089005335 S-adenosylmethionine binding site [chemical binding]; other site 879089005336 Phosphotransferase enzyme family; Region: APH; pfam01636 879089005337 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 879089005338 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 879089005339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089005340 putative substrate translocation pore; other site 879089005341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089005342 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 879089005343 MarR family; Region: MarR; pfam01047 879089005344 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 879089005345 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 879089005346 homodimer interface [polypeptide binding]; other site 879089005347 substrate-cofactor binding pocket; other site 879089005348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089005349 catalytic residue [active] 879089005350 dipeptidase PepV; Reviewed; Region: PRK07318 879089005351 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 879089005352 active site 879089005353 metal binding site [ion binding]; metal-binding site 879089005354 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 879089005355 nudix motif; other site 879089005356 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 879089005357 putative substrate binding site [chemical binding]; other site 879089005358 putative ATP binding site [chemical binding]; other site 879089005359 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 879089005360 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 879089005361 active site 879089005362 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 879089005363 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 879089005364 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 879089005365 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 879089005366 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 879089005367 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 879089005368 substrate binding site [chemical binding]; other site 879089005369 active site 879089005370 catalytic residues [active] 879089005371 heterodimer interface [polypeptide binding]; other site 879089005372 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 879089005373 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 879089005374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089005375 catalytic residue [active] 879089005376 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 879089005377 active site 879089005378 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 879089005379 active site 879089005380 ribulose/triose binding site [chemical binding]; other site 879089005381 phosphate binding site [ion binding]; other site 879089005382 substrate (anthranilate) binding pocket [chemical binding]; other site 879089005383 product (indole) binding pocket [chemical binding]; other site 879089005384 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 879089005385 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 879089005386 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 879089005387 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 879089005388 Glutamine amidotransferase class-I; Region: GATase; pfam00117 879089005389 glutamine binding [chemical binding]; other site 879089005390 catalytic triad [active] 879089005391 anthranilate synthase component I; Provisional; Region: PRK13570 879089005392 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 879089005393 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 879089005394 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 879089005395 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 879089005396 putative catalytic cysteine [active] 879089005397 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 879089005398 putative active site [active] 879089005399 metal binding site [ion binding]; metal-binding site 879089005400 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 879089005401 dimer interface [polypeptide binding]; other site 879089005402 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 879089005403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089005404 Walker A/P-loop; other site 879089005405 ATP binding site [chemical binding]; other site 879089005406 Q-loop/lid; other site 879089005407 ABC transporter signature motif; other site 879089005408 Walker B; other site 879089005409 D-loop; other site 879089005410 H-loop/switch region; other site 879089005411 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 879089005412 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 879089005413 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 879089005414 putative dimer interface [polypeptide binding]; other site 879089005415 catalytic triad [active] 879089005416 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 879089005417 aconitate hydratase; Validated; Region: PRK09277 879089005418 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 879089005419 substrate binding site [chemical binding]; other site 879089005420 ligand binding site [chemical binding]; other site 879089005421 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 879089005422 substrate binding site [chemical binding]; other site 879089005423 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 879089005424 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 879089005425 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 879089005426 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 879089005427 ATP binding site [chemical binding]; other site 879089005428 putative Mg++ binding site [ion binding]; other site 879089005429 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 879089005430 nucleotide binding region [chemical binding]; other site 879089005431 ATP-binding site [chemical binding]; other site 879089005432 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 879089005433 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 879089005434 Walker A/P-loop; other site 879089005435 ATP binding site [chemical binding]; other site 879089005436 Q-loop/lid; other site 879089005437 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 879089005438 ABC transporter signature motif; other site 879089005439 Walker B; other site 879089005440 D-loop; other site 879089005441 H-loop/switch region; other site 879089005442 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 879089005443 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 879089005444 active site 879089005445 metal binding site [ion binding]; metal-binding site 879089005446 DNA binding site [nucleotide binding] 879089005447 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 879089005448 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 879089005449 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 879089005450 putative acyl-acceptor binding pocket; other site 879089005451 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 879089005452 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 879089005453 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 879089005454 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 879089005455 Walker A/P-loop; other site 879089005456 ATP binding site [chemical binding]; other site 879089005457 Q-loop/lid; other site 879089005458 ABC transporter signature motif; other site 879089005459 Walker B; other site 879089005460 D-loop; other site 879089005461 H-loop/switch region; other site 879089005462 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 879089005463 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 879089005464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089005465 Walker A/P-loop; other site 879089005466 ATP binding site [chemical binding]; other site 879089005467 Q-loop/lid; other site 879089005468 ABC transporter signature motif; other site 879089005469 Walker B; other site 879089005470 D-loop; other site 879089005471 H-loop/switch region; other site 879089005472 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 879089005473 active site 879089005474 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 879089005475 elongation factor Ts; Provisional; Region: tsf; PRK09377 879089005476 UBA/TS-N domain; Region: UBA; pfam00627 879089005477 Elongation factor TS; Region: EF_TS; pfam00889 879089005478 Elongation factor TS; Region: EF_TS; pfam00889 879089005479 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 879089005480 rRNA interaction site [nucleotide binding]; other site 879089005481 S8 interaction site; other site 879089005482 putative laminin-1 binding site; other site 879089005483 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 879089005484 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 879089005485 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 879089005486 active site turn [active] 879089005487 phosphorylation site [posttranslational modification] 879089005488 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 879089005489 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 879089005490 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 879089005491 putative active site [active] 879089005492 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 879089005493 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 879089005494 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 879089005495 putative active site [active] 879089005496 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 879089005497 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 879089005498 HIGH motif; other site 879089005499 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 879089005500 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 879089005501 active site 879089005502 KMSKS motif; other site 879089005503 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 879089005504 tRNA binding surface [nucleotide binding]; other site 879089005505 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 879089005506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 879089005507 FeS/SAM binding site; other site 879089005508 Methyltransferase domain; Region: Methyltransf_31; pfam13847 879089005509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089005510 S-adenosylmethionine binding site [chemical binding]; other site 879089005511 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 879089005512 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 879089005513 active site 879089005514 dimer interface [polypeptide binding]; other site 879089005515 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 879089005516 Ligand Binding Site [chemical binding]; other site 879089005517 Molecular Tunnel; other site 879089005518 S-adenosylmethionine synthetase; Validated; Region: PRK05250 879089005519 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 879089005520 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 879089005521 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 879089005522 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 879089005523 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 879089005524 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 879089005525 tetramer (dimer of dimers) interface [polypeptide binding]; other site 879089005526 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 879089005527 NAD binding site [chemical binding]; other site 879089005528 dimer interface [polypeptide binding]; other site 879089005529 substrate binding site [chemical binding]; other site 879089005530 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 879089005531 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 879089005532 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 879089005533 nudix motif; other site 879089005534 Uncharacterized conserved protein [Function unknown]; Region: COG0759 879089005535 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 879089005536 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 879089005537 metal binding site [ion binding]; metal-binding site 879089005538 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 879089005539 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 879089005540 acyl-activating enzyme (AAE) consensus motif; other site 879089005541 putative AMP binding site [chemical binding]; other site 879089005542 putative active site [active] 879089005543 putative CoA binding site [chemical binding]; other site 879089005544 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 879089005545 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 879089005546 substrate binding site [chemical binding]; other site 879089005547 oxyanion hole (OAH) forming residues; other site 879089005548 trimer interface [polypeptide binding]; other site 879089005549 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 879089005550 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 879089005551 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 879089005552 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 879089005553 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 879089005554 dimer interface [polypeptide binding]; other site 879089005555 tetramer interface [polypeptide binding]; other site 879089005556 PYR/PP interface [polypeptide binding]; other site 879089005557 TPP binding site [chemical binding]; other site 879089005558 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 879089005559 TPP-binding site; other site 879089005560 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 879089005561 chorismate binding enzyme; Region: Chorismate_bind; cl10555 879089005562 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 879089005563 UbiA prenyltransferase family; Region: UbiA; pfam01040 879089005564 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 879089005565 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 879089005566 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 879089005567 FAD binding site [chemical binding]; other site 879089005568 cystathionine beta-lyase; Provisional; Region: PRK08064 879089005569 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 879089005570 homodimer interface [polypeptide binding]; other site 879089005571 substrate-cofactor binding pocket; other site 879089005572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089005573 catalytic residue [active] 879089005574 cystathionine gamma-synthase; Reviewed; Region: PRK08247 879089005575 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 879089005576 homodimer interface [polypeptide binding]; other site 879089005577 substrate-cofactor binding pocket; other site 879089005578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089005579 catalytic residue [active] 879089005580 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 879089005581 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 879089005582 THF binding site; other site 879089005583 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 879089005584 substrate binding site [chemical binding]; other site 879089005585 THF binding site; other site 879089005586 zinc-binding site [ion binding]; other site 879089005587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089005588 Major Facilitator Superfamily; Region: MFS_1; pfam07690 879089005589 putative substrate translocation pore; other site 879089005590 ferric uptake regulator; Provisional; Region: fur; PRK09462 879089005591 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 879089005592 metal binding site 2 [ion binding]; metal-binding site 879089005593 putative DNA binding helix; other site 879089005594 metal binding site 1 [ion binding]; metal-binding site 879089005595 dimer interface [polypeptide binding]; other site 879089005596 structural Zn2+ binding site [ion binding]; other site 879089005597 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 879089005598 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 879089005599 NAD binding site [chemical binding]; other site 879089005600 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 879089005601 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 879089005602 inhibitor-cofactor binding pocket; inhibition site 879089005603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089005604 catalytic residue [active] 879089005605 Predicted membrane protein [Function unknown]; Region: COG4129 879089005606 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 879089005607 hypothetical protein; Provisional; Region: PRK13662 879089005608 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 879089005609 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 879089005610 putative NAD(P) binding site [chemical binding]; other site 879089005611 active site 879089005612 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 879089005613 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 879089005614 minor groove reading motif; other site 879089005615 helix-hairpin-helix signature motif; other site 879089005616 substrate binding pocket [chemical binding]; other site 879089005617 active site 879089005618 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 879089005619 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 879089005620 DNA binding and oxoG recognition site [nucleotide binding] 879089005621 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 879089005622 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 879089005623 trimer interface [polypeptide binding]; other site 879089005624 active site 879089005625 WVELL protein; Region: WVELL; pfam14043 879089005626 recombination regulator RecX; Provisional; Region: recX; PRK14135 879089005627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 879089005628 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 879089005629 NAD(P) binding site [chemical binding]; other site 879089005630 active site 879089005631 Predicted integral membrane protein [Function unknown]; Region: COG0392 879089005632 Uncharacterized conserved protein [Function unknown]; Region: COG2898 879089005633 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 879089005634 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 879089005635 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 879089005636 Cation efflux family; Region: Cation_efflux; pfam01545 879089005637 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 879089005638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 879089005639 PAS fold; Region: PAS_4; pfam08448 879089005640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 879089005641 putative active site [active] 879089005642 heme pocket [chemical binding]; other site 879089005643 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 879089005644 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 879089005645 dimer interface [polypeptide binding]; other site 879089005646 putative CheW interface [polypeptide binding]; other site 879089005647 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 879089005648 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 879089005649 dimer interface [polypeptide binding]; other site 879089005650 active site 879089005651 Mn binding site [ion binding]; other site 879089005652 TRAM domain; Region: TRAM; cl01282 879089005653 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 879089005654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089005655 S-adenosylmethionine binding site [chemical binding]; other site 879089005656 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 879089005657 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 879089005658 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 879089005659 Substrate-binding site [chemical binding]; other site 879089005660 Substrate specificity [chemical binding]; other site 879089005661 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 879089005662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 879089005663 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 879089005664 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 879089005665 active site 879089005666 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 879089005667 flavodoxin, short chain; Region: flav_short; TIGR01753 879089005668 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 879089005669 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 879089005670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089005671 Major Facilitator Superfamily; Region: MFS_1; pfam07690 879089005672 putative substrate translocation pore; other site 879089005673 rod-share determining protein MreBH; Provisional; Region: PRK13929 879089005674 MreB and similar proteins; Region: MreB_like; cd10225 879089005675 nucleotide binding site [chemical binding]; other site 879089005676 Mg binding site [ion binding]; other site 879089005677 putative protofilament interaction site [polypeptide binding]; other site 879089005678 RodZ interaction site [polypeptide binding]; other site 879089005679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089005680 S-adenosylmethionine binding site [chemical binding]; other site 879089005681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 879089005682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 879089005683 Uncharacterized conserved protein [Function unknown]; Region: COG4748 879089005684 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 879089005685 Uncharacterized conserved protein [Function unknown]; Region: COG3589 879089005686 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 879089005687 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 879089005688 methionine cluster; other site 879089005689 active site 879089005690 phosphorylation site [posttranslational modification] 879089005691 metal binding site [ion binding]; metal-binding site 879089005692 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 879089005693 active site 879089005694 P-loop; other site 879089005695 phosphorylation site [posttranslational modification] 879089005696 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 879089005697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089005698 Walker A motif; other site 879089005699 ATP binding site [chemical binding]; other site 879089005700 Walker B motif; other site 879089005701 arginine finger; other site 879089005702 Transcriptional antiterminator [Transcription]; Region: COG3933 879089005703 PRD domain; Region: PRD; pfam00874 879089005704 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 879089005705 active pocket/dimerization site; other site 879089005706 active site 879089005707 phosphorylation site [posttranslational modification] 879089005708 PRD domain; Region: PRD; pfam00874 879089005709 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 879089005710 DEAD-like helicases superfamily; Region: DEXDc; smart00487 879089005711 ATP binding site [chemical binding]; other site 879089005712 putative Mg++ binding site [ion binding]; other site 879089005713 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 879089005714 nucleotide binding region [chemical binding]; other site 879089005715 ATP-binding site [chemical binding]; other site 879089005716 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 879089005717 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 879089005718 Transcriptional regulators [Transcription]; Region: PurR; COG1609 879089005719 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 879089005720 DNA binding site [nucleotide binding] 879089005721 domain linker motif; other site 879089005722 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 879089005723 dimerization interface [polypeptide binding]; other site 879089005724 ligand binding site [chemical binding]; other site 879089005725 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 879089005726 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 879089005727 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 879089005728 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 879089005729 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 879089005730 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 879089005731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089005732 dimer interface [polypeptide binding]; other site 879089005733 conserved gate region; other site 879089005734 putative PBP binding loops; other site 879089005735 ABC-ATPase subunit interface; other site 879089005736 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 879089005737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089005738 dimer interface [polypeptide binding]; other site 879089005739 conserved gate region; other site 879089005740 putative PBP binding loops; other site 879089005741 ABC-ATPase subunit interface; other site 879089005742 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 879089005743 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 879089005744 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 879089005745 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 879089005746 active site 879089005747 dimer interface [polypeptide binding]; other site 879089005748 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 879089005749 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 879089005750 active site 879089005751 FMN binding site [chemical binding]; other site 879089005752 substrate binding site [chemical binding]; other site 879089005753 3Fe-4S cluster binding site [ion binding]; other site 879089005754 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 879089005755 domain interface; other site 879089005756 Transcriptional regulator [Transcription]; Region: LysR; COG0583 879089005757 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 879089005758 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 879089005759 putative dimerization interface [polypeptide binding]; other site 879089005760 Predicted acetyltransferase [General function prediction only]; Region: COG3153 879089005761 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 879089005762 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 879089005763 putative active site [active] 879089005764 metal binding site [ion binding]; metal-binding site 879089005765 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 879089005766 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 879089005767 substrate binding pocket [chemical binding]; other site 879089005768 membrane-bound complex binding site; other site 879089005769 hinge residues; other site 879089005770 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 879089005771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089005772 Walker A/P-loop; other site 879089005773 ATP binding site [chemical binding]; other site 879089005774 Q-loop/lid; other site 879089005775 ABC transporter signature motif; other site 879089005776 Walker B; other site 879089005777 D-loop; other site 879089005778 H-loop/switch region; other site 879089005779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089005780 dimer interface [polypeptide binding]; other site 879089005781 conserved gate region; other site 879089005782 putative PBP binding loops; other site 879089005783 ABC-ATPase subunit interface; other site 879089005784 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 879089005785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 879089005786 dimer interface [polypeptide binding]; other site 879089005787 phosphorylation site [posttranslational modification] 879089005788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089005789 ATP binding site [chemical binding]; other site 879089005790 Mg2+ binding site [ion binding]; other site 879089005791 G-X-G motif; other site 879089005792 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 879089005793 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 879089005794 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 879089005795 active site 879089005796 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 879089005797 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 879089005798 putative NAD(P) binding site [chemical binding]; other site 879089005799 active site 879089005800 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 879089005801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089005802 active site 879089005803 phosphorylation site [posttranslational modification] 879089005804 intermolecular recognition site; other site 879089005805 dimerization interface [polypeptide binding]; other site 879089005806 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 879089005807 DNA binding site [nucleotide binding] 879089005808 FtsX-like permease family; Region: FtsX; pfam02687 879089005809 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 879089005810 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 879089005811 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 879089005812 Walker A/P-loop; other site 879089005813 ATP binding site [chemical binding]; other site 879089005814 Q-loop/lid; other site 879089005815 ABC transporter signature motif; other site 879089005816 Walker B; other site 879089005817 D-loop; other site 879089005818 H-loop/switch region; other site 879089005819 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 879089005820 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 879089005821 ADP binding site [chemical binding]; other site 879089005822 magnesium binding site [ion binding]; other site 879089005823 putative shikimate binding site; other site 879089005824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 879089005825 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 879089005826 TRAM domain; Region: TRAM; pfam01938 879089005827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089005828 S-adenosylmethionine binding site [chemical binding]; other site 879089005829 putative lipid kinase; Reviewed; Region: PRK13337 879089005830 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 879089005831 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 879089005832 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 879089005833 GatB domain; Region: GatB_Yqey; smart00845 879089005834 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 879089005835 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 879089005836 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 879089005837 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 879089005838 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 879089005839 putative dimer interface [polypeptide binding]; other site 879089005840 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 879089005841 putative dimer interface [polypeptide binding]; other site 879089005842 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 879089005843 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 879089005844 nucleotide binding pocket [chemical binding]; other site 879089005845 K-X-D-G motif; other site 879089005846 catalytic site [active] 879089005847 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 879089005848 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 879089005849 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 879089005850 Dimer interface [polypeptide binding]; other site 879089005851 BRCT sequence motif; other site 879089005852 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 879089005853 Part of AAA domain; Region: AAA_19; pfam13245 879089005854 Family description; Region: UvrD_C_2; pfam13538 879089005855 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 879089005856 PcrB family; Region: PcrB; pfam01884 879089005857 substrate binding site [chemical binding]; other site 879089005858 putative active site [active] 879089005859 dimer interface [polypeptide binding]; other site 879089005860 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 879089005861 Na2 binding site [ion binding]; other site 879089005862 putative substrate binding site 1 [chemical binding]; other site 879089005863 Na binding site 1 [ion binding]; other site 879089005864 putative substrate binding site 2 [chemical binding]; other site 879089005865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 879089005866 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 879089005867 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 879089005868 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 879089005869 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 879089005870 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 879089005871 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 879089005872 purine monophosphate binding site [chemical binding]; other site 879089005873 dimer interface [polypeptide binding]; other site 879089005874 putative catalytic residues [active] 879089005875 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 879089005876 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 879089005877 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 879089005878 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 879089005879 active site 879089005880 substrate binding site [chemical binding]; other site 879089005881 cosubstrate binding site; other site 879089005882 catalytic site [active] 879089005883 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 879089005884 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 879089005885 dimerization interface [polypeptide binding]; other site 879089005886 putative ATP binding site [chemical binding]; other site 879089005887 amidophosphoribosyltransferase; Provisional; Region: PRK06781 879089005888 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 879089005889 active site 879089005890 tetramer interface [polypeptide binding]; other site 879089005891 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 879089005892 active site 879089005893 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 879089005894 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 879089005895 dimerization interface [polypeptide binding]; other site 879089005896 ATP binding site [chemical binding]; other site 879089005897 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 879089005898 dimerization interface [polypeptide binding]; other site 879089005899 ATP binding site [chemical binding]; other site 879089005900 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 879089005901 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 879089005902 putative active site [active] 879089005903 catalytic triad [active] 879089005904 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 879089005905 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 879089005906 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 879089005907 ATP binding site [chemical binding]; other site 879089005908 active site 879089005909 substrate binding site [chemical binding]; other site 879089005910 adenylosuccinate lyase; Provisional; Region: PRK07492 879089005911 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 879089005912 tetramer interface [polypeptide binding]; other site 879089005913 active site 879089005914 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 879089005915 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 879089005916 NAD binding site [chemical binding]; other site 879089005917 ATP-grasp domain; Region: ATP-grasp; pfam02222 879089005918 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 879089005919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 879089005920 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 879089005921 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 879089005922 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 879089005923 Zn2+ binding site [ion binding]; other site 879089005924 Mg2+ binding site [ion binding]; other site 879089005925 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 879089005926 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 879089005927 Walker A/P-loop; other site 879089005928 ATP binding site [chemical binding]; other site 879089005929 Q-loop/lid; other site 879089005930 ABC transporter signature motif; other site 879089005931 Walker B; other site 879089005932 D-loop; other site 879089005933 H-loop/switch region; other site 879089005934 peptidase T; Region: peptidase-T; TIGR01882 879089005935 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 879089005936 metal binding site [ion binding]; metal-binding site 879089005937 dimer interface [polypeptide binding]; other site 879089005938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 879089005939 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 879089005940 active site 879089005941 putative catalytic site [active] 879089005942 DNA binding site [nucleotide binding] 879089005943 putative phosphate binding site [ion binding]; other site 879089005944 metal binding site A [ion binding]; metal-binding site 879089005945 AP binding site [nucleotide binding]; other site 879089005946 metal binding site B [ion binding]; metal-binding site 879089005947 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 879089005948 23S rRNA binding site [nucleotide binding]; other site 879089005949 L21 binding site [polypeptide binding]; other site 879089005950 L13 binding site [polypeptide binding]; other site 879089005951 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 879089005952 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 879089005953 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 879089005954 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 879089005955 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 879089005956 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089005957 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 879089005958 Substrate binding site [chemical binding]; other site 879089005959 Leucine rich repeat; Region: LRR_8; pfam13855 879089005960 LRR adjacent; Region: LRR_adjacent; pfam08191 879089005961 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 879089005962 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 879089005963 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 879089005964 DNA binding residues [nucleotide binding] 879089005965 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 879089005966 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 879089005967 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 879089005968 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 879089005969 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 879089005970 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 879089005971 RimM N-terminal domain; Region: RimM; pfam01782 879089005972 PRC-barrel domain; Region: PRC; pfam05239 879089005973 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 879089005974 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 879089005975 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 879089005976 catalytic triad [active] 879089005977 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 879089005978 KH domain; Region: KH_4; pfam13083 879089005979 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 879089005980 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 879089005981 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 879089005982 signal recognition particle protein; Provisional; Region: PRK10867 879089005983 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 879089005984 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 879089005985 P loop; other site 879089005986 GTP binding site [chemical binding]; other site 879089005987 Signal peptide binding domain; Region: SRP_SPB; pfam02978 879089005988 putative DNA-binding protein; Validated; Region: PRK00118 879089005989 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 879089005990 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 879089005991 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 879089005992 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 879089005993 P loop; other site 879089005994 GTP binding site [chemical binding]; other site 879089005995 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 879089005996 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 879089005997 Walker A/P-loop; other site 879089005998 ATP binding site [chemical binding]; other site 879089005999 Q-loop/lid; other site 879089006000 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 879089006001 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 879089006002 linker region; other site 879089006003 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 879089006004 ABC transporter signature motif; other site 879089006005 Walker B; other site 879089006006 D-loop; other site 879089006007 H-loop/switch region; other site 879089006008 ribonuclease III; Reviewed; Region: rnc; PRK00102 879089006009 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 879089006010 dimerization interface [polypeptide binding]; other site 879089006011 active site 879089006012 metal binding site [ion binding]; metal-binding site 879089006013 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 879089006014 dsRNA binding site [nucleotide binding]; other site 879089006015 acyl carrier protein; Provisional; Region: acpP; PRK00982 879089006016 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 879089006017 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 879089006018 NAD(P) binding site [chemical binding]; other site 879089006019 homotetramer interface [polypeptide binding]; other site 879089006020 homodimer interface [polypeptide binding]; other site 879089006021 active site 879089006022 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 879089006023 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 879089006024 putative phosphate acyltransferase; Provisional; Region: PRK05331 879089006025 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 879089006026 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 879089006027 active site 2 [active] 879089006028 active site 1 [active] 879089006029 Y-family of DNA polymerases; Region: PolY; cl12025 879089006030 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 879089006031 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 879089006032 generic binding surface II; other site 879089006033 ssDNA binding site; other site 879089006034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 879089006035 ATP binding site [chemical binding]; other site 879089006036 putative Mg++ binding site [ion binding]; other site 879089006037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 879089006038 nucleotide binding region [chemical binding]; other site 879089006039 ATP-binding site [chemical binding]; other site 879089006040 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 879089006041 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 879089006042 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 879089006043 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 879089006044 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 879089006045 putative L-serine binding site [chemical binding]; other site 879089006046 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 879089006047 DAK2 domain; Region: Dak2; pfam02734 879089006048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 879089006049 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 879089006050 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 879089006051 Thiamine pyrophosphokinase; Region: TPK; cd07995 879089006052 active site 879089006053 dimerization interface [polypeptide binding]; other site 879089006054 thiamine binding site [chemical binding]; other site 879089006055 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 879089006056 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 879089006057 substrate binding site [chemical binding]; other site 879089006058 hexamer interface [polypeptide binding]; other site 879089006059 metal binding site [ion binding]; metal-binding site 879089006060 GTPase RsgA; Reviewed; Region: PRK00098 879089006061 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 879089006062 RNA binding site [nucleotide binding]; other site 879089006063 homodimer interface [polypeptide binding]; other site 879089006064 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 879089006065 GTPase/Zn-binding domain interface [polypeptide binding]; other site 879089006066 GTP/Mg2+ binding site [chemical binding]; other site 879089006067 G4 box; other site 879089006068 G1 box; other site 879089006069 Switch I region; other site 879089006070 G2 box; other site 879089006071 G3 box; other site 879089006072 Switch II region; other site 879089006073 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 879089006074 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 879089006075 active site 879089006076 ATP binding site [chemical binding]; other site 879089006077 substrate binding site [chemical binding]; other site 879089006078 activation loop (A-loop); other site 879089006079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 879089006080 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 879089006081 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 879089006082 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 879089006083 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 879089006084 Protein phosphatase 2C; Region: PP2C; pfam00481 879089006085 active site 879089006086 16S rRNA methyltransferase B; Provisional; Region: PRK14902 879089006087 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 879089006088 putative RNA binding site [nucleotide binding]; other site 879089006089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089006090 S-adenosylmethionine binding site [chemical binding]; other site 879089006091 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 879089006092 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 879089006093 putative active site [active] 879089006094 substrate binding site [chemical binding]; other site 879089006095 putative cosubstrate binding site; other site 879089006096 catalytic site [active] 879089006097 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 879089006098 substrate binding site [chemical binding]; other site 879089006099 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 879089006100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 879089006101 ATP binding site [chemical binding]; other site 879089006102 putative Mg++ binding site [ion binding]; other site 879089006103 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 879089006104 ATP-binding site [chemical binding]; other site 879089006105 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 879089006106 Flavoprotein; Region: Flavoprotein; pfam02441 879089006107 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 879089006108 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 879089006109 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 879089006110 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 879089006111 catalytic site [active] 879089006112 G-X2-G-X-G-K; other site 879089006113 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 879089006114 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 879089006115 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 879089006116 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 879089006117 Domain of unknown function (DUF814); Region: DUF814; pfam05670 879089006118 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 879089006119 putative NAD(P) binding site [chemical binding]; other site 879089006120 homodimer interface [polypeptide binding]; other site 879089006121 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 879089006122 active site 879089006123 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 879089006124 active site 879089006125 dimer interface [polypeptide binding]; other site 879089006126 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 879089006127 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 879089006128 heterodimer interface [polypeptide binding]; other site 879089006129 active site 879089006130 FMN binding site [chemical binding]; other site 879089006131 homodimer interface [polypeptide binding]; other site 879089006132 substrate binding site [chemical binding]; other site 879089006133 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 879089006134 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 879089006135 FAD binding pocket [chemical binding]; other site 879089006136 FAD binding motif [chemical binding]; other site 879089006137 phosphate binding motif [ion binding]; other site 879089006138 beta-alpha-beta structure motif; other site 879089006139 NAD binding pocket [chemical binding]; other site 879089006140 Iron coordination center [ion binding]; other site 879089006141 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 879089006142 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 879089006143 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 879089006144 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 879089006145 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 879089006146 ATP-grasp domain; Region: ATP-grasp_4; cl17255 879089006147 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 879089006148 IMP binding site; other site 879089006149 dimer interface [polypeptide binding]; other site 879089006150 interdomain contacts; other site 879089006151 partial ornithine binding site; other site 879089006152 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 879089006153 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 879089006154 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 879089006155 catalytic site [active] 879089006156 subunit interface [polypeptide binding]; other site 879089006157 dihydroorotase; Validated; Region: pyrC; PRK09357 879089006158 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 879089006159 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 879089006160 active site 879089006161 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 879089006162 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 879089006163 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 879089006164 uracil transporter; Provisional; Region: PRK10720 879089006165 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 879089006166 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 879089006167 active site 879089006168 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 879089006169 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 879089006170 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 879089006171 RNA binding surface [nucleotide binding]; other site 879089006172 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 879089006173 active site 879089006174 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 879089006175 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 879089006176 Sulfate transporter family; Region: Sulfate_transp; pfam00916 879089006177 multidrug efflux protein; Reviewed; Region: PRK01766 879089006178 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 879089006179 cation binding site [ion binding]; other site 879089006180 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 879089006181 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 879089006182 metal binding site [ion binding]; metal-binding site 879089006183 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 879089006184 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 879089006185 ABC-ATPase subunit interface; other site 879089006186 dimer interface [polypeptide binding]; other site 879089006187 putative PBP binding regions; other site 879089006188 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 879089006189 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 879089006190 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 879089006191 MarR family; Region: MarR; pfam01047 879089006192 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 879089006193 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 879089006194 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 879089006195 protein binding site [polypeptide binding]; other site 879089006196 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 879089006197 Catalytic dyad [active] 879089006198 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 879089006199 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 879089006200 metal-binding site [ion binding] 879089006201 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 879089006202 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 879089006203 metal-binding site [ion binding] 879089006204 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 879089006205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089006206 motif II; other site 879089006207 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 879089006208 putative homodimer interface [polypeptide binding]; other site 879089006209 putative homotetramer interface [polypeptide binding]; other site 879089006210 putative allosteric switch controlling residues; other site 879089006211 putative metal binding site [ion binding]; other site 879089006212 putative homodimer-homodimer interface [polypeptide binding]; other site 879089006213 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 879089006214 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 879089006215 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 879089006216 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 879089006217 hypothetical protein; Provisional; Region: PRK13672 879089006218 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 879089006219 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 879089006220 methionine sulfoxide reductase B; Provisional; Region: PRK00222 879089006221 SelR domain; Region: SelR; pfam01641 879089006222 methionine sulfoxide reductase A; Provisional; Region: PRK14054 879089006223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 879089006224 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 879089006225 active site 879089006226 catalytic triad [active] 879089006227 oxyanion hole [active] 879089006228 EDD domain protein, DegV family; Region: DegV; TIGR00762 879089006229 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 879089006230 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 879089006231 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 879089006232 HTH domain; Region: HTH_11; pfam08279 879089006233 FOG: CBS domain [General function prediction only]; Region: COG0517 879089006234 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 879089006235 PEP synthetase regulatory protein; Provisional; Region: PRK05339 879089006236 pyruvate phosphate dikinase; Provisional; Region: PRK09279 879089006237 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 879089006238 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 879089006239 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 879089006240 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 879089006241 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 879089006242 Predicted membrane protein [Function unknown]; Region: COG4129 879089006243 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 879089006244 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 879089006245 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 879089006246 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 879089006247 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 879089006248 active site 879089006249 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 879089006250 substrate binding site [chemical binding]; other site 879089006251 metal binding site [ion binding]; metal-binding site 879089006252 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 879089006253 Methyltransferase domain; Region: Methyltransf_18; pfam12847 879089006254 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 879089006255 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 879089006256 folate binding site [chemical binding]; other site 879089006257 NADP+ binding site [chemical binding]; other site 879089006258 thymidylate synthase; Region: thym_sym; TIGR03284 879089006259 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 879089006260 dimerization interface [polypeptide binding]; other site 879089006261 active site 879089006262 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 879089006263 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 879089006264 Walker A/P-loop; other site 879089006265 ATP binding site [chemical binding]; other site 879089006266 Q-loop/lid; other site 879089006267 ABC transporter signature motif; other site 879089006268 Walker B; other site 879089006269 D-loop; other site 879089006270 H-loop/switch region; other site 879089006271 ABC transporter; Region: ABC_tran_2; pfam12848 879089006272 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 879089006273 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 879089006274 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 879089006275 Potassium binding sites [ion binding]; other site 879089006276 Cesium cation binding sites [ion binding]; other site 879089006277 manganese transport transcriptional regulator; Provisional; Region: PRK03902 879089006278 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 879089006279 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 879089006280 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 879089006281 DNA-binding site [nucleotide binding]; DNA binding site 879089006282 RNA-binding motif; other site 879089006283 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 879089006284 RNA/DNA hybrid binding site [nucleotide binding]; other site 879089006285 active site 879089006286 5'-3' exonuclease; Region: 53EXOc; smart00475 879089006287 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 879089006288 active site 879089006289 metal binding site 1 [ion binding]; metal-binding site 879089006290 putative 5' ssDNA interaction site; other site 879089006291 metal binding site 3; metal-binding site 879089006292 metal binding site 2 [ion binding]; metal-binding site 879089006293 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 879089006294 putative DNA binding site [nucleotide binding]; other site 879089006295 putative metal binding site [ion binding]; other site 879089006296 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 879089006297 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 879089006298 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 879089006299 putative active site [active] 879089006300 xanthine permease; Region: pbuX; TIGR03173 879089006301 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 879089006302 active site 879089006303 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 879089006304 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 879089006305 active site 879089006306 Zn binding site [ion binding]; other site 879089006307 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 879089006308 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 879089006309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 879089006310 cell division protein GpsB; Provisional; Region: PRK14127 879089006311 DivIVA domain; Region: DivI1A_domain; TIGR03544 879089006312 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 879089006313 hypothetical protein; Provisional; Region: PRK13660 879089006314 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 879089006315 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 879089006316 Transglycosylase; Region: Transgly; pfam00912 879089006317 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 879089006318 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 879089006319 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 879089006320 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 879089006321 minor groove reading motif; other site 879089006322 helix-hairpin-helix signature motif; other site 879089006323 substrate binding pocket [chemical binding]; other site 879089006324 active site 879089006325 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 879089006326 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 879089006327 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 879089006328 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 879089006329 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 879089006330 putative dimer interface [polypeptide binding]; other site 879089006331 putative anticodon binding site; other site 879089006332 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 879089006333 homodimer interface [polypeptide binding]; other site 879089006334 motif 1; other site 879089006335 motif 2; other site 879089006336 active site 879089006337 motif 3; other site 879089006338 aspartate aminotransferase; Provisional; Region: PRK05764 879089006339 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 879089006340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089006341 homodimer interface [polypeptide binding]; other site 879089006342 catalytic residue [active] 879089006343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 879089006344 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 879089006345 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 879089006346 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 879089006347 active site 879089006348 catalytic site [active] 879089006349 substrate binding site [chemical binding]; other site 879089006350 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 879089006351 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 879089006352 putative Mg++ binding site [ion binding]; other site 879089006353 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 879089006354 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 879089006355 tetramerization interface [polypeptide binding]; other site 879089006356 active site 879089006357 pantoate--beta-alanine ligase; Region: panC; TIGR00018 879089006358 Pantoate-beta-alanine ligase; Region: PanC; cd00560 879089006359 active site 879089006360 ATP-binding site [chemical binding]; other site 879089006361 pantoate-binding site; other site 879089006362 HXXH motif; other site 879089006363 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 879089006364 active site 879089006365 oligomerization interface [polypeptide binding]; other site 879089006366 metal binding site [ion binding]; metal-binding site 879089006367 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 879089006368 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 879089006369 catalytic residues [active] 879089006370 Biotin operon repressor [Transcription]; Region: BirA; COG1654 879089006371 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 879089006372 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 879089006373 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 879089006374 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 879089006375 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 879089006376 active site 879089006377 NTP binding site [chemical binding]; other site 879089006378 metal binding triad [ion binding]; metal-binding site 879089006379 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 879089006380 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 879089006381 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 879089006382 active site 879089006383 dimer interfaces [polypeptide binding]; other site 879089006384 catalytic residues [active] 879089006385 dihydrodipicolinate reductase; Provisional; Region: PRK00048 879089006386 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 879089006387 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 879089006388 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 879089006389 homodimer interface [polypeptide binding]; other site 879089006390 metal binding site [ion binding]; metal-binding site 879089006391 Uncharacterized conserved protein [Function unknown]; Region: COG1284 879089006392 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 879089006393 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 879089006394 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 879089006395 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 879089006396 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 879089006397 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 879089006398 metal binding site [ion binding]; metal-binding site 879089006399 active site 879089006400 I-site; other site 879089006401 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 879089006402 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 879089006403 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 879089006404 metal binding site [ion binding]; metal-binding site 879089006405 active site 879089006406 I-site; other site 879089006407 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 879089006408 malate dehydrogenase; Provisional; Region: PRK13529 879089006409 Malic enzyme, N-terminal domain; Region: malic; pfam00390 879089006410 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 879089006411 NAD(P) binding pocket [chemical binding]; other site 879089006412 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 879089006413 Beta-lactamase; Region: Beta-lactamase; pfam00144 879089006414 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 879089006415 Pyruvate formate lyase 1; Region: PFL1; cd01678 879089006416 coenzyme A binding site [chemical binding]; other site 879089006417 active site 879089006418 catalytic residues [active] 879089006419 glycine loop; other site 879089006420 HI0933-like protein; Region: HI0933_like; pfam03486 879089006421 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 879089006422 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 879089006423 Predicted membrane protein [Function unknown]; Region: COG4347 879089006424 hypothetical protein; Provisional; Region: PRK03636 879089006425 UPF0302 domain; Region: UPF0302; pfam08864 879089006426 IDEAL domain; Region: IDEAL; pfam08858 879089006427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 879089006428 binding surface 879089006429 TPR motif; other site 879089006430 TPR repeat; Region: TPR_11; pfam13414 879089006431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 879089006432 binding surface 879089006433 TPR motif; other site 879089006434 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 879089006435 binding surface 879089006436 TPR motif; other site 879089006437 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 879089006438 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 879089006439 hinge; other site 879089006440 active site 879089006441 prephenate dehydrogenase; Validated; Region: PRK06545 879089006442 prephenate dehydrogenase; Validated; Region: PRK08507 879089006443 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 879089006444 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 879089006445 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 879089006446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089006447 homodimer interface [polypeptide binding]; other site 879089006448 catalytic residue [active] 879089006449 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 879089006450 homotrimer interaction site [polypeptide binding]; other site 879089006451 active site 879089006452 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 879089006453 active site 879089006454 dimer interface [polypeptide binding]; other site 879089006455 metal binding site [ion binding]; metal-binding site 879089006456 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 879089006457 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 879089006458 Tetramer interface [polypeptide binding]; other site 879089006459 active site 879089006460 FMN-binding site [chemical binding]; other site 879089006461 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 879089006462 active site 879089006463 multimer interface [polypeptide binding]; other site 879089006464 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 879089006465 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 879089006466 substrate binding pocket [chemical binding]; other site 879089006467 chain length determination region; other site 879089006468 substrate-Mg2+ binding site; other site 879089006469 catalytic residues [active] 879089006470 aspartate-rich region 1; other site 879089006471 active site lid residues [active] 879089006472 aspartate-rich region 2; other site 879089006473 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 879089006474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089006475 S-adenosylmethionine binding site [chemical binding]; other site 879089006476 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 879089006477 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 879089006478 homodecamer interface [polypeptide binding]; other site 879089006479 GTP cyclohydrolase I; Provisional; Region: PLN03044 879089006480 active site 879089006481 putative catalytic site residues [active] 879089006482 zinc binding site [ion binding]; other site 879089006483 GTP-CH-I/GFRP interaction surface; other site 879089006484 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 879089006485 IHF dimer interface [polypeptide binding]; other site 879089006486 IHF - DNA interface [nucleotide binding]; other site 879089006487 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 879089006488 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 879089006489 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 879089006490 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 879089006491 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 879089006492 GTP-binding protein Der; Reviewed; Region: PRK00093 879089006493 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 879089006494 G1 box; other site 879089006495 GTP/Mg2+ binding site [chemical binding]; other site 879089006496 Switch I region; other site 879089006497 G2 box; other site 879089006498 Switch II region; other site 879089006499 G3 box; other site 879089006500 G4 box; other site 879089006501 G5 box; other site 879089006502 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 879089006503 G1 box; other site 879089006504 GTP/Mg2+ binding site [chemical binding]; other site 879089006505 Switch I region; other site 879089006506 G2 box; other site 879089006507 G3 box; other site 879089006508 Switch II region; other site 879089006509 G4 box; other site 879089006510 G5 box; other site 879089006511 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 879089006512 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 879089006513 RNA binding site [nucleotide binding]; other site 879089006514 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 879089006515 RNA binding site [nucleotide binding]; other site 879089006516 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 879089006517 RNA binding site [nucleotide binding]; other site 879089006518 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 879089006519 RNA binding site [nucleotide binding]; other site 879089006520 cytidylate kinase; Provisional; Region: cmk; PRK00023 879089006521 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 879089006522 CMP-binding site; other site 879089006523 The sites determining sugar specificity; other site 879089006524 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 879089006525 active site 879089006526 homotetramer interface [polypeptide binding]; other site 879089006527 homodimer interface [polypeptide binding]; other site 879089006528 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 879089006529 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 879089006530 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 879089006531 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 879089006532 ATP binding site [chemical binding]; other site 879089006533 putative Mg++ binding site [ion binding]; other site 879089006534 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 879089006535 nucleotide binding region [chemical binding]; other site 879089006536 ATP-binding site [chemical binding]; other site 879089006537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 879089006538 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089006539 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089006540 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089006541 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089006542 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089006543 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089006544 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089006545 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089006546 Predicted membrane protein [Function unknown]; Region: COG3601 879089006547 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 879089006548 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 879089006549 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 879089006550 dimerization interface [polypeptide binding]; other site 879089006551 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 879089006552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 879089006553 dimer interface [polypeptide binding]; other site 879089006554 phosphorylation site [posttranslational modification] 879089006555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089006556 ATP binding site [chemical binding]; other site 879089006557 Mg2+ binding site [ion binding]; other site 879089006558 G-X-G motif; other site 879089006559 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 879089006560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089006561 active site 879089006562 phosphorylation site [posttranslational modification] 879089006563 intermolecular recognition site; other site 879089006564 dimerization interface [polypeptide binding]; other site 879089006565 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 879089006566 DNA binding site [nucleotide binding] 879089006567 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 879089006568 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 879089006569 RNA binding surface [nucleotide binding]; other site 879089006570 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 879089006571 active site 879089006572 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 879089006573 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 879089006574 diaminopimelate decarboxylase; Region: lysA; TIGR01048 879089006575 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 879089006576 active site 879089006577 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 879089006578 substrate binding site [chemical binding]; other site 879089006579 catalytic residues [active] 879089006580 dimer interface [polypeptide binding]; other site 879089006581 purine nucleoside phosphorylase; Provisional; Region: PRK08202 879089006582 phosphopentomutase; Provisional; Region: PRK05362 879089006583 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 879089006584 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 879089006585 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 879089006586 active site 879089006587 Int/Topo IB signature motif; other site 879089006588 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 879089006589 metal binding site 2 [ion binding]; metal-binding site 879089006590 putative DNA binding helix; other site 879089006591 metal binding site 1 [ion binding]; metal-binding site 879089006592 dimer interface [polypeptide binding]; other site 879089006593 structural Zn2+ binding site [ion binding]; other site 879089006594 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 879089006595 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 879089006596 ABC-ATPase subunit interface; other site 879089006597 dimer interface [polypeptide binding]; other site 879089006598 putative PBP binding regions; other site 879089006599 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 879089006600 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 879089006601 ABC-ATPase subunit interface; other site 879089006602 dimer interface [polypeptide binding]; other site 879089006603 putative PBP binding regions; other site 879089006604 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 879089006605 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 879089006606 putative ligand binding residues [chemical binding]; other site 879089006607 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 879089006608 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 879089006609 Walker A/P-loop; other site 879089006610 ATP binding site [chemical binding]; other site 879089006611 Q-loop/lid; other site 879089006612 ABC transporter signature motif; other site 879089006613 Walker B; other site 879089006614 D-loop; other site 879089006615 H-loop/switch region; other site 879089006616 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 879089006617 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 879089006618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 879089006619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 879089006620 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 879089006621 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 879089006622 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 879089006623 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 879089006624 Walker A/P-loop; other site 879089006625 ATP binding site [chemical binding]; other site 879089006626 Q-loop/lid; other site 879089006627 ABC transporter signature motif; other site 879089006628 Walker B; other site 879089006629 D-loop; other site 879089006630 H-loop/switch region; other site 879089006631 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 879089006632 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 879089006633 dimer interface [polypeptide binding]; other site 879089006634 ADP-ribose binding site [chemical binding]; other site 879089006635 active site 879089006636 nudix motif; other site 879089006637 metal binding site [ion binding]; metal-binding site 879089006638 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 879089006639 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 879089006640 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 879089006641 active site 879089006642 DNA polymerase IV; Validated; Region: PRK02406 879089006643 DNA binding site [nucleotide binding] 879089006644 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 879089006645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 879089006646 NAD(P) binding site [chemical binding]; other site 879089006647 active site 879089006648 ribonuclease Z; Region: RNase_Z; TIGR02651 879089006649 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 879089006650 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 879089006651 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 879089006652 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 879089006653 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 879089006654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089006655 Coenzyme A binding pocket [chemical binding]; other site 879089006656 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 879089006657 6-phosphogluconate dehydratase; Region: edd; TIGR01196 879089006658 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 879089006659 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 879089006660 PYR/PP interface [polypeptide binding]; other site 879089006661 dimer interface [polypeptide binding]; other site 879089006662 TPP binding site [chemical binding]; other site 879089006663 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 879089006664 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 879089006665 TPP-binding site [chemical binding]; other site 879089006666 dimer interface [polypeptide binding]; other site 879089006667 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 879089006668 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 879089006669 putative valine binding site [chemical binding]; other site 879089006670 dimer interface [polypeptide binding]; other site 879089006671 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 879089006672 ketol-acid reductoisomerase; Provisional; Region: PRK05479 879089006673 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 879089006674 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 879089006675 2-isopropylmalate synthase; Validated; Region: PRK00915 879089006676 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 879089006677 active site 879089006678 catalytic residues [active] 879089006679 metal binding site [ion binding]; metal-binding site 879089006680 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 879089006681 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 879089006682 tartrate dehydrogenase; Region: TTC; TIGR02089 879089006683 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 879089006684 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 879089006685 substrate binding site [chemical binding]; other site 879089006686 ligand binding site [chemical binding]; other site 879089006687 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 879089006688 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 879089006689 substrate binding site [chemical binding]; other site 879089006690 threonine dehydratase; Validated; Region: PRK08639 879089006691 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 879089006692 tetramer interface [polypeptide binding]; other site 879089006693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089006694 catalytic residue [active] 879089006695 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 879089006696 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 879089006697 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 879089006698 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 879089006699 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 879089006700 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 879089006701 Transcriptional regulators [Transcription]; Region: PurR; COG1609 879089006702 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 879089006703 DNA binding site [nucleotide binding] 879089006704 domain linker motif; other site 879089006705 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 879089006706 dimerization interface [polypeptide binding]; other site 879089006707 ligand binding site [chemical binding]; other site 879089006708 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 879089006709 intersubunit interface [polypeptide binding]; other site 879089006710 active site 879089006711 catalytic residue [active] 879089006712 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 879089006713 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 879089006714 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 879089006715 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 879089006716 active pocket/dimerization site; other site 879089006717 active site 879089006718 phosphorylation site [posttranslational modification] 879089006719 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 879089006720 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 879089006721 putative active site [active] 879089006722 SIS domain; Region: SIS; pfam01380 879089006723 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 879089006724 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 879089006725 dimer interface [polypeptide binding]; other site 879089006726 active site 879089006727 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 879089006728 dimer interface [polypeptide binding]; other site 879089006729 active site 879089006730 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 879089006731 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 879089006732 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 879089006733 active site 879089006734 phosphorylation site [posttranslational modification] 879089006735 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 879089006736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089006737 DNA-binding site [nucleotide binding]; DNA binding site 879089006738 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 879089006739 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 879089006740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089006741 DNA-binding site [nucleotide binding]; DNA binding site 879089006742 UTRA domain; Region: UTRA; pfam07702 879089006743 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 879089006744 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 879089006745 active site 879089006746 catalytic tetrad [active] 879089006747 acetolactate synthase; Reviewed; Region: PRK08617 879089006748 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 879089006749 PYR/PP interface [polypeptide binding]; other site 879089006750 dimer interface [polypeptide binding]; other site 879089006751 TPP binding site [chemical binding]; other site 879089006752 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 879089006753 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 879089006754 TPP-binding site [chemical binding]; other site 879089006755 dimer interface [polypeptide binding]; other site 879089006756 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 879089006757 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 879089006758 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 879089006759 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 879089006760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089006761 dimer interface [polypeptide binding]; other site 879089006762 conserved gate region; other site 879089006763 ABC-ATPase subunit interface; other site 879089006764 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 879089006765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089006766 dimer interface [polypeptide binding]; other site 879089006767 conserved gate region; other site 879089006768 ABC-ATPase subunit interface; other site 879089006769 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 879089006770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089006771 active site 879089006772 phosphorylation site [posttranslational modification] 879089006773 intermolecular recognition site; other site 879089006774 dimerization interface [polypeptide binding]; other site 879089006775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 879089006776 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 879089006777 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 879089006778 dimerization interface [polypeptide binding]; other site 879089006779 Histidine kinase; Region: His_kinase; pfam06580 879089006780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089006781 ATP binding site [chemical binding]; other site 879089006782 Mg2+ binding site [ion binding]; other site 879089006783 G-X-G motif; other site 879089006784 Predicted integral membrane protein [Function unknown]; Region: COG5578 879089006785 Uncharacterized conserved protein [Function unknown]; Region: COG3538 879089006786 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 879089006787 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 879089006788 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 879089006789 active site 879089006790 metal binding site [ion binding]; metal-binding site 879089006791 homodimer interface [polypeptide binding]; other site 879089006792 catalytic site [active] 879089006793 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 879089006794 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 879089006795 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 879089006796 active site 879089006797 catalytic site [active] 879089006798 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 879089006799 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 879089006800 DNA-binding site [nucleotide binding]; DNA binding site 879089006801 RNA-binding motif; other site 879089006802 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 879089006803 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 879089006804 active site 879089006805 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 879089006806 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 879089006807 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 879089006808 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 879089006809 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 879089006810 active site 879089006811 HIGH motif; other site 879089006812 nucleotide binding site [chemical binding]; other site 879089006813 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 879089006814 active site 879089006815 KMSKS motif; other site 879089006816 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 879089006817 tRNA binding surface [nucleotide binding]; other site 879089006818 anticodon binding site; other site 879089006819 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 879089006820 DivIVA protein; Region: DivIVA; pfam05103 879089006821 DivIVA domain; Region: DivI1A_domain; TIGR03544 879089006822 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 879089006823 HTH domain; Region: HTH_11; pfam08279 879089006824 3H domain; Region: 3H; pfam02829 879089006825 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 879089006826 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 879089006827 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 879089006828 catalytic residue [active] 879089006829 L-aspartate oxidase; Provisional; Region: PRK08071 879089006830 L-aspartate oxidase; Provisional; Region: PRK06175 879089006831 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 879089006832 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 879089006833 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 879089006834 dimerization interface [polypeptide binding]; other site 879089006835 active site 879089006836 quinolinate synthetase; Provisional; Region: PRK09375 879089006837 Transposase; Region: HTH_Tnp_1; cl17663 879089006838 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 879089006839 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006840 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006841 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006842 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006843 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006844 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 879089006845 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006846 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089006847 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006848 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 879089006849 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006850 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006851 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006852 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006853 Leucine rich repeat; Region: LRR_8; pfam13855 879089006854 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089006855 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089006856 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 879089006857 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006858 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006859 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006860 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 879089006861 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006862 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006863 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006864 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006865 Leucine rich repeat; Region: LRR_8; pfam13855 879089006866 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006867 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 879089006868 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006869 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006870 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006871 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006872 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 879089006873 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006874 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006875 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006876 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 879089006877 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089006878 Mga helix-turn-helix domain; Region: Mga; pfam05043 879089006879 Methyltransferase domain; Region: Methyltransf_31; pfam13847 879089006880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089006881 S-adenosylmethionine binding site [chemical binding]; other site 879089006882 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 879089006883 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 879089006884 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 879089006885 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 879089006886 LRR adjacent; Region: LRR_adjacent; pfam08191 879089006887 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089006888 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089006889 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089006890 Transposase; Region: HTH_Tnp_1; cl17663 879089006891 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 879089006892 Leucine-rich repeats; other site 879089006893 Leucine rich repeat; Region: LRR_8; pfam13855 879089006894 Substrate binding site [chemical binding]; other site 879089006895 Leucine rich repeat; Region: LRR_8; pfam13855 879089006896 LRR adjacent; Region: LRR_adjacent; pfam08191 879089006897 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089006898 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089006899 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089006900 Uncharacterized conserved protein [Function unknown]; Region: COG5361 879089006901 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 879089006902 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 879089006903 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 879089006904 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089006905 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089006906 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089006907 LRR adjacent; Region: LRR_adjacent; pfam08191 879089006908 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089006909 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089006910 Transposase; Region: HTH_Tnp_1; cl17663 879089006911 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 879089006912 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 879089006913 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 879089006914 Leucine-rich repeats; other site 879089006915 Substrate binding site [chemical binding]; other site 879089006916 LRR adjacent; Region: LRR_adjacent; pfam08191 879089006917 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 879089006918 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 879089006919 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 879089006920 RNA binding surface [nucleotide binding]; other site 879089006921 YGGT family; Region: YGGT; pfam02325 879089006922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 879089006923 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 879089006924 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 879089006925 catalytic residue [active] 879089006926 cell division protein FtsZ; Validated; Region: PRK09330 879089006927 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 879089006928 nucleotide binding site [chemical binding]; other site 879089006929 SulA interaction site; other site 879089006930 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 879089006931 Cell division protein FtsA; Region: FtsA; smart00842 879089006932 Cell division protein FtsA; Region: FtsA; pfam14450 879089006933 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 879089006934 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 879089006935 Cell division protein FtsQ; Region: FtsQ; pfam03799 879089006936 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 879089006937 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 879089006938 active site 879089006939 homodimer interface [polypeptide binding]; other site 879089006940 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 879089006941 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 879089006942 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 879089006943 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 879089006944 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 879089006945 Mg++ binding site [ion binding]; other site 879089006946 putative catalytic motif [active] 879089006947 putative substrate binding site [chemical binding]; other site 879089006948 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 879089006949 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 879089006950 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 879089006951 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 879089006952 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 879089006953 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 879089006954 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 879089006955 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 879089006956 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 879089006957 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 879089006958 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 879089006959 MraW methylase family; Region: Methyltransf_5; pfam01795 879089006960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 879089006961 MraZ protein; Region: MraZ; pfam02381 879089006962 MraZ protein; Region: MraZ; pfam02381 879089006963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 879089006964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089006965 putative substrate translocation pore; other site 879089006966 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 879089006967 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 879089006968 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 879089006969 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 879089006970 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 879089006971 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 879089006972 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 879089006973 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 879089006974 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 879089006975 hypothetical protein; Provisional; Region: PRK13670 879089006976 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 879089006977 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 879089006978 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 879089006979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089006980 Walker A/P-loop; other site 879089006981 ATP binding site [chemical binding]; other site 879089006982 Q-loop/lid; other site 879089006983 ABC transporter signature motif; other site 879089006984 Walker B; other site 879089006985 D-loop; other site 879089006986 H-loop/switch region; other site 879089006987 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 879089006988 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 879089006989 protein binding site [polypeptide binding]; other site 879089006990 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 879089006991 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 879089006992 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 879089006993 active site 879089006994 (T/H)XGH motif; other site 879089006995 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 879089006996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089006997 S-adenosylmethionine binding site [chemical binding]; other site 879089006998 hypothetical protein; Provisional; Region: PRK02886 879089006999 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 879089007000 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 879089007001 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 879089007002 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 879089007003 UbiA prenyltransferase family; Region: UbiA; pfam01040 879089007004 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 879089007005 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 879089007006 Ion transport protein; Region: Ion_trans; pfam00520 879089007007 Ion channel; Region: Ion_trans_2; pfam07885 879089007008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 879089007009 MOSC domain; Region: MOSC; pfam03473 879089007010 3-alpha domain; Region: 3-alpha; pfam03475 879089007011 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 879089007012 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 879089007013 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 879089007014 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 879089007015 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 879089007016 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 879089007017 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 879089007018 active site 879089007019 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 879089007020 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 879089007021 ring oligomerisation interface [polypeptide binding]; other site 879089007022 ATP/Mg binding site [chemical binding]; other site 879089007023 stacking interactions; other site 879089007024 hinge regions; other site 879089007025 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 879089007026 oligomerisation interface [polypeptide binding]; other site 879089007027 mobile loop; other site 879089007028 roof hairpin; other site 879089007029 CAAX protease self-immunity; Region: Abi; pfam02517 879089007030 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 879089007031 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 879089007032 CoA binding domain; Region: CoA_binding; pfam02629 879089007033 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 879089007034 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 879089007035 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 879089007036 ABC transporter; Region: ABC_tran_2; pfam12848 879089007037 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 879089007038 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 879089007039 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 879089007040 UGMP family protein; Validated; Region: PRK09604 879089007041 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 879089007042 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 879089007043 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089007044 Coenzyme A binding pocket [chemical binding]; other site 879089007045 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 879089007046 Glycoprotease family; Region: Peptidase_M22; pfam00814 879089007047 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 879089007048 camphor resistance protein CrcB; Provisional; Region: PRK14214 879089007049 camphor resistance protein CrcB; Provisional; Region: PRK14231 879089007050 Uncharacterized conserved protein [Function unknown]; Region: COG4832 879089007051 Phosphotransferase enzyme family; Region: APH; pfam01636 879089007052 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 879089007053 substrate binding site [chemical binding]; other site 879089007054 Phosphotransferase enzyme family; Region: APH; pfam01636 879089007055 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 879089007056 active site 879089007057 ATP binding site [chemical binding]; other site 879089007058 Cna protein B-type domain; Region: Cna_B; pfam05738 879089007059 Cna protein B-type domain; Region: Cna_B; pfam05738 879089007060 Cna protein B-type domain; Region: Cna_B; pfam05738 879089007061 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089007062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089007063 non-specific DNA binding site [nucleotide binding]; other site 879089007064 salt bridge; other site 879089007065 sequence-specific DNA binding site [nucleotide binding]; other site 879089007066 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 879089007067 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 879089007068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 879089007069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 879089007070 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 879089007071 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 879089007072 substrate binding pocket [chemical binding]; other site 879089007073 argininosuccinate synthase; Provisional; Region: PRK13820 879089007074 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 879089007075 ANP binding site [chemical binding]; other site 879089007076 Substrate Binding Site II [chemical binding]; other site 879089007077 Substrate Binding Site I [chemical binding]; other site 879089007078 argininosuccinate lyase; Provisional; Region: PRK00855 879089007079 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 879089007080 active sites [active] 879089007081 tetramer interface [polypeptide binding]; other site 879089007082 BCCT family transporter; Region: BCCT; pfam02028 879089007083 hypothetical protein; Provisional; Region: PRK06357 879089007084 active site 879089007085 intersubunit interface [polypeptide binding]; other site 879089007086 Zn2+ binding site [ion binding]; other site 879089007087 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 879089007088 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 879089007089 putative substrate binding site [chemical binding]; other site 879089007090 putative ATP binding site [chemical binding]; other site 879089007091 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 879089007092 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 879089007093 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 879089007094 active site 879089007095 P-loop; other site 879089007096 phosphorylation site [posttranslational modification] 879089007097 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089007098 active site 879089007099 phosphorylation site [posttranslational modification] 879089007100 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 879089007101 PRD domain; Region: PRD; pfam00874 879089007102 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 879089007103 active site 879089007104 P-loop; other site 879089007105 phosphorylation site [posttranslational modification] 879089007106 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 879089007107 active site 879089007108 phosphorylation site [posttranslational modification] 879089007109 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 879089007110 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089007111 DNA-binding site [nucleotide binding]; DNA binding site 879089007112 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 879089007113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089007114 homodimer interface [polypeptide binding]; other site 879089007115 catalytic residue [active] 879089007116 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 879089007117 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 879089007118 active site 879089007119 multimer interface [polypeptide binding]; other site 879089007120 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 879089007121 predicted active site [active] 879089007122 catalytic triad [active] 879089007123 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 879089007124 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 879089007125 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 879089007126 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 879089007127 G1 box; other site 879089007128 GTP/Mg2+ binding site [chemical binding]; other site 879089007129 Switch I region; other site 879089007130 G2 box; other site 879089007131 G3 box; other site 879089007132 Switch II region; other site 879089007133 G4 box; other site 879089007134 G5 box; other site 879089007135 Nucleoside recognition; Region: Gate; pfam07670 879089007136 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 879089007137 Nucleoside recognition; Region: Gate; pfam07670 879089007138 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 879089007139 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 879089007140 putative active site [active] 879089007141 putative metal binding site [ion binding]; other site 879089007142 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 879089007143 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 879089007144 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 879089007145 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 879089007146 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 879089007147 active site 879089007148 dimer interface [polypeptide binding]; other site 879089007149 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 879089007150 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 879089007151 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 879089007152 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 879089007153 dimer interface [polypeptide binding]; other site 879089007154 FMN binding site [chemical binding]; other site 879089007155 NADPH bind site [chemical binding]; other site 879089007156 Helix-turn-helix domain; Region: HTH_17; pfam12728 879089007157 putative heme peroxidase; Provisional; Region: PRK12276 879089007158 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 879089007159 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 879089007160 Walker A/P-loop; other site 879089007161 ATP binding site [chemical binding]; other site 879089007162 Q-loop/lid; other site 879089007163 ABC transporter signature motif; other site 879089007164 Walker B; other site 879089007165 D-loop; other site 879089007166 H-loop/switch region; other site 879089007167 FtsX-like permease family; Region: FtsX; pfam02687 879089007168 FtsX-like permease family; Region: FtsX; pfam02687 879089007169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089007170 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 879089007171 Coenzyme A binding pocket [chemical binding]; other site 879089007172 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 879089007173 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 879089007174 active site 879089007175 substrate binding site [chemical binding]; other site 879089007176 metal binding site [ion binding]; metal-binding site 879089007177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 879089007178 YbbR-like protein; Region: YbbR; pfam07949 879089007179 YbbR-like protein; Region: YbbR; pfam07949 879089007180 YbbR-like protein; Region: YbbR; pfam07949 879089007181 Uncharacterized conserved protein [Function unknown]; Region: COG1624 879089007182 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 879089007183 maltose phosphorylase; Provisional; Region: PRK13807 879089007184 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 879089007185 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 879089007186 Predicted integral membrane protein [Function unknown]; Region: COG5521 879089007187 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 879089007188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089007189 dimer interface [polypeptide binding]; other site 879089007190 conserved gate region; other site 879089007191 putative PBP binding loops; other site 879089007192 ABC-ATPase subunit interface; other site 879089007193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089007194 dimer interface [polypeptide binding]; other site 879089007195 conserved gate region; other site 879089007196 putative PBP binding loops; other site 879089007197 ABC-ATPase subunit interface; other site 879089007198 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 879089007199 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 879089007200 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 879089007201 homodimer interface [polypeptide binding]; other site 879089007202 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 879089007203 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 879089007204 active site 879089007205 homodimer interface [polypeptide binding]; other site 879089007206 catalytic site [active] 879089007207 CAAX protease self-immunity; Region: Abi; cl00558 879089007208 Transcriptional regulators [Transcription]; Region: PurR; COG1609 879089007209 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 879089007210 DNA binding site [nucleotide binding] 879089007211 domain linker motif; other site 879089007212 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 879089007213 ligand binding site [chemical binding]; other site 879089007214 dimerization interface [polypeptide binding]; other site 879089007215 Amino acid permease; Region: AA_permease_2; pfam13520 879089007216 K+ potassium transporter; Region: K_trans; cl15781 879089007217 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089007218 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 879089007219 ligand binding site [chemical binding]; other site 879089007220 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089007221 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 879089007222 ligand binding site [chemical binding]; other site 879089007223 flexible hinge region; other site 879089007224 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 879089007225 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 879089007226 intersubunit interface [polypeptide binding]; other site 879089007227 active site 879089007228 zinc binding site [ion binding]; other site 879089007229 Na+ binding site [ion binding]; other site 879089007230 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 879089007231 intersubunit interface [polypeptide binding]; other site 879089007232 active site 879089007233 zinc binding site [ion binding]; other site 879089007234 Na+ binding site [ion binding]; other site 879089007235 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 879089007236 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 879089007237 active site 879089007238 P-loop; other site 879089007239 phosphorylation site [posttranslational modification] 879089007240 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089007241 active site 879089007242 phosphorylation site [posttranslational modification] 879089007243 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 879089007244 HTH domain; Region: HTH_11; pfam08279 879089007245 Mga helix-turn-helix domain; Region: Mga; pfam05043 879089007246 PRD domain; Region: PRD; pfam00874 879089007247 PRD domain; Region: PRD; pfam00874 879089007248 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 879089007249 active site 879089007250 P-loop; other site 879089007251 phosphorylation site [posttranslational modification] 879089007252 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 879089007253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089007254 Walker A/P-loop; other site 879089007255 ATP binding site [chemical binding]; other site 879089007256 Q-loop/lid; other site 879089007257 ABC transporter signature motif; other site 879089007258 Walker B; other site 879089007259 D-loop; other site 879089007260 H-loop/switch region; other site 879089007261 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 879089007262 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 879089007263 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 879089007264 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089007265 Coenzyme A binding pocket [chemical binding]; other site 879089007266 Transcriptional regulators [Transcription]; Region: GntR; COG1802 879089007267 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 879089007268 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 879089007269 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 879089007270 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089007271 DNA-binding site [nucleotide binding]; DNA binding site 879089007272 UTRA domain; Region: UTRA; pfam07702 879089007273 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 879089007274 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 879089007275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 879089007276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 879089007277 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 879089007278 putative dimerization interface [polypeptide binding]; other site 879089007279 Predicted membrane protein [Function unknown]; Region: COG2855 879089007280 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 879089007281 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 879089007282 putative metal binding site [ion binding]; other site 879089007283 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 879089007284 homodimer interface [polypeptide binding]; other site 879089007285 chemical substrate binding site [chemical binding]; other site 879089007286 oligomer interface [polypeptide binding]; other site 879089007287 metal binding site [ion binding]; metal-binding site 879089007288 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 879089007289 catalytic residues [active] 879089007290 flavodoxin; Provisional; Region: PRK09271 879089007291 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 879089007292 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 879089007293 dimer interface [polypeptide binding]; other site 879089007294 putative radical transfer pathway; other site 879089007295 diiron center [ion binding]; other site 879089007296 tyrosyl radical; other site 879089007297 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 879089007298 Class I ribonucleotide reductase; Region: RNR_I; cd01679 879089007299 active site 879089007300 dimer interface [polypeptide binding]; other site 879089007301 catalytic residues [active] 879089007302 effector binding site; other site 879089007303 R2 peptide binding site; other site 879089007304 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 879089007305 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 879089007306 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 879089007307 SCP-2 sterol transfer family; Region: SCP2; cl01225 879089007308 CsbD-like; Region: CsbD; cl17424 879089007309 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 879089007310 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 879089007311 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 879089007312 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 879089007313 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 879089007314 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 879089007315 conserved cys residue [active] 879089007316 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 879089007317 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 879089007318 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 879089007319 Cupin; Region: Cupin_1; pfam00190 879089007320 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 879089007321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 879089007322 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089007323 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089007324 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 879089007325 ligand binding site [chemical binding]; other site 879089007326 flexible hinge region; other site 879089007327 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 879089007328 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 879089007329 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 879089007330 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 879089007331 dimer interface [polypeptide binding]; other site 879089007332 active site 879089007333 metal binding site [ion binding]; metal-binding site 879089007334 glutathione binding site [chemical binding]; other site 879089007335 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 879089007336 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 879089007337 FMN binding site [chemical binding]; other site 879089007338 substrate binding site [chemical binding]; other site 879089007339 putative catalytic residue [active] 879089007340 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 879089007341 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 879089007342 Coenzyme A transferase; Region: CoA_trans; smart00882 879089007343 Coenzyme A transferase; Region: CoA_trans; cl17247 879089007344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089007345 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 879089007346 Walker A motif; other site 879089007347 ATP binding site [chemical binding]; other site 879089007348 Walker B motif; other site 879089007349 arginine finger; other site 879089007350 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 879089007351 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 879089007352 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 879089007353 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 879089007354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 879089007355 metal binding site [ion binding]; metal-binding site 879089007356 active site 879089007357 I-site; other site 879089007358 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 879089007359 classical (c) SDRs; Region: SDR_c; cd05233 879089007360 NAD(P) binding site [chemical binding]; other site 879089007361 active site 879089007362 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 879089007363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 879089007364 Tic20-like protein; Region: Tic20; pfam09685 879089007365 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 879089007366 Cna protein B-type domain; Region: Cna_B; pfam05738 879089007367 Collagen binding domain; Region: Collagen_bind; pfam05737 879089007368 Cna protein B-type domain; Region: Cna_B; pfam05738 879089007369 Cna protein B-type domain; Region: Cna_B; pfam05738 879089007370 Cna protein B-type domain; Region: Cna_B; pfam05738 879089007371 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089007372 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 879089007373 Cna protein B-type domain; Region: Cna_B; pfam05738 879089007374 Collagen binding domain; Region: Collagen_bind; pfam05737 879089007375 Cna protein B-type domain; Region: Cna_B; pfam05738 879089007376 Cna protein B-type domain; Region: Cna_B; pfam05738 879089007377 Cna protein B-type domain; Region: Cna_B; pfam05738 879089007378 Cna protein B-type domain; Region: Cna_B; pfam05738 879089007379 Cna protein B-type domain; Region: Cna_B; pfam05738 879089007380 Cna protein B-type domain; Region: Cna_B; pfam05738 879089007381 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089007382 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089007383 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089007384 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089007385 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089007386 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 879089007387 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 879089007388 active site 879089007389 catalytic site [active] 879089007390 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 879089007391 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 879089007392 Walker A/P-loop; other site 879089007393 ATP binding site [chemical binding]; other site 879089007394 Q-loop/lid; other site 879089007395 ABC transporter signature motif; other site 879089007396 Walker B; other site 879089007397 D-loop; other site 879089007398 H-loop/switch region; other site 879089007399 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 879089007400 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 879089007401 ABC-ATPase subunit interface; other site 879089007402 dimer interface [polypeptide binding]; other site 879089007403 putative PBP binding regions; other site 879089007404 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 879089007405 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 879089007406 intersubunit interface [polypeptide binding]; other site 879089007407 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 879089007408 heme-binding site [chemical binding]; other site 879089007409 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 879089007410 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 879089007411 heme-binding site [chemical binding]; other site 879089007412 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 879089007413 heme-binding site [chemical binding]; other site 879089007414 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 879089007415 heme uptake protein IsdC; Region: IsdC; TIGR03656 879089007416 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 879089007417 heme-binding site [chemical binding]; other site 879089007418 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 879089007419 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 879089007420 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 879089007421 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 879089007422 active site 879089007423 Zn binding site [ion binding]; other site 879089007424 Competence protein CoiA-like family; Region: CoiA; cl11541 879089007425 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 879089007426 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 879089007427 ArsC family; Region: ArsC; pfam03960 879089007428 putative catalytic residues [active] 879089007429 thiol/disulfide switch; other site 879089007430 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 879089007431 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 879089007432 Walker A/P-loop; other site 879089007433 ATP binding site [chemical binding]; other site 879089007434 Q-loop/lid; other site 879089007435 ABC transporter signature motif; other site 879089007436 Walker B; other site 879089007437 D-loop; other site 879089007438 H-loop/switch region; other site 879089007439 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 879089007440 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 879089007441 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 879089007442 Walker A/P-loop; other site 879089007443 ATP binding site [chemical binding]; other site 879089007444 Q-loop/lid; other site 879089007445 ABC transporter signature motif; other site 879089007446 Walker B; other site 879089007447 D-loop; other site 879089007448 H-loop/switch region; other site 879089007449 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 879089007450 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 879089007451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089007452 dimer interface [polypeptide binding]; other site 879089007453 conserved gate region; other site 879089007454 putative PBP binding loops; other site 879089007455 ABC-ATPase subunit interface; other site 879089007456 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 879089007457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089007458 dimer interface [polypeptide binding]; other site 879089007459 conserved gate region; other site 879089007460 putative PBP binding loops; other site 879089007461 ABC-ATPase subunit interface; other site 879089007462 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 879089007463 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 879089007464 peptide binding site [polypeptide binding]; other site 879089007465 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 879089007466 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 879089007467 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 879089007468 active site 879089007469 HIGH motif; other site 879089007470 dimer interface [polypeptide binding]; other site 879089007471 KMSKS motif; other site 879089007472 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 879089007473 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 879089007474 MarR family; Region: MarR; pfam01047 879089007475 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 879089007476 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 879089007477 dimer interface [polypeptide binding]; other site 879089007478 active site 879089007479 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 879089007480 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 879089007481 dimer interface [polypeptide binding]; other site 879089007482 active site 879089007483 CoA binding pocket [chemical binding]; other site 879089007484 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 879089007485 SH3-like domain; Region: SH3_8; pfam13457 879089007486 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 879089007487 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 879089007488 catalytic core [active] 879089007489 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 879089007490 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 879089007491 Clp amino terminal domain; Region: Clp_N; pfam02861 879089007492 Clp amino terminal domain; Region: Clp_N; pfam02861 879089007493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089007494 Walker A motif; other site 879089007495 ATP binding site [chemical binding]; other site 879089007496 Walker B motif; other site 879089007497 arginine finger; other site 879089007498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089007499 Walker A motif; other site 879089007500 ATP binding site [chemical binding]; other site 879089007501 Walker B motif; other site 879089007502 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 879089007503 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 879089007504 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 879089007505 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 879089007506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089007507 active site 879089007508 motif I; other site 879089007509 motif II; other site 879089007510 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 879089007511 Predicted acetyltransferase [General function prediction only]; Region: COG3393 879089007512 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 879089007513 ferrochelatase; Provisional; Region: PRK12435 879089007514 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 879089007515 C-terminal domain interface [polypeptide binding]; other site 879089007516 active site 879089007517 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 879089007518 active site 879089007519 N-terminal domain interface [polypeptide binding]; other site 879089007520 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 879089007521 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 879089007522 substrate binding site [chemical binding]; other site 879089007523 active site 879089007524 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 879089007525 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 879089007526 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 879089007527 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 879089007528 Walker A/P-loop; other site 879089007529 ATP binding site [chemical binding]; other site 879089007530 Q-loop/lid; other site 879089007531 ABC transporter signature motif; other site 879089007532 Walker B; other site 879089007533 D-loop; other site 879089007534 H-loop/switch region; other site 879089007535 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 879089007536 HIT family signature motif; other site 879089007537 catalytic residue [active] 879089007538 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 879089007539 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 879089007540 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 879089007541 SurA N-terminal domain; Region: SurA_N_3; cl07813 879089007542 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 879089007543 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 879089007544 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 879089007545 generic binding surface II; other site 879089007546 generic binding surface I; other site 879089007547 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 879089007548 Zn2+ binding site [ion binding]; other site 879089007549 Mg2+ binding site [ion binding]; other site 879089007550 Uncharacterized conserved protein [Function unknown]; Region: COG4717 879089007551 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 879089007552 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 879089007553 active site 879089007554 metal binding site [ion binding]; metal-binding site 879089007555 DNA binding site [nucleotide binding] 879089007556 hypothetical protein; Provisional; Region: PRK13676 879089007557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 879089007558 fumarate hydratase; Reviewed; Region: fumC; PRK00485 879089007559 Class II fumarases; Region: Fumarase_classII; cd01362 879089007560 active site 879089007561 tetramer interface [polypeptide binding]; other site 879089007562 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 879089007563 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 879089007564 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 879089007565 Walker A/P-loop; other site 879089007566 ATP binding site [chemical binding]; other site 879089007567 Q-loop/lid; other site 879089007568 ABC transporter signature motif; other site 879089007569 Walker B; other site 879089007570 D-loop; other site 879089007571 H-loop/switch region; other site 879089007572 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 879089007573 Transglycosylase; Region: Transgly; pfam00912 879089007574 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 879089007575 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 879089007576 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 879089007577 Low molecular weight phosphatase family; Region: LMWPc; cl00105 879089007578 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 879089007579 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 879089007580 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 879089007581 Domain of unknown function DUF21; Region: DUF21; pfam01595 879089007582 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 879089007583 Transporter associated domain; Region: CorC_HlyC; smart01091 879089007584 Transcriptional regulator [Transcription]; Region: LysR; COG0583 879089007585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 879089007586 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 879089007587 putative dimerization interface [polypeptide binding]; other site 879089007588 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 879089007589 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 879089007590 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 879089007591 active site 879089007592 FMN binding site [chemical binding]; other site 879089007593 substrate binding site [chemical binding]; other site 879089007594 putative catalytic residue [active] 879089007595 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 879089007596 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 879089007597 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 879089007598 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 879089007599 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 879089007600 shikimate binding site; other site 879089007601 NAD(P) binding site [chemical binding]; other site 879089007602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089007603 putative substrate translocation pore; other site 879089007604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 879089007605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089007606 Major Facilitator Superfamily; Region: MFS_1; pfam07690 879089007607 putative substrate translocation pore; other site 879089007608 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 879089007609 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 879089007610 Walker A/P-loop; other site 879089007611 ATP binding site [chemical binding]; other site 879089007612 Q-loop/lid; other site 879089007613 ABC transporter signature motif; other site 879089007614 Walker B; other site 879089007615 D-loop; other site 879089007616 H-loop/switch region; other site 879089007617 Predicted transcriptional regulators [Transcription]; Region: COG1725 879089007618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 879089007619 DNA-binding site [nucleotide binding]; DNA binding site 879089007620 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 879089007621 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 879089007622 DNA binding site [nucleotide binding] 879089007623 active site 879089007624 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 879089007625 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 879089007626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 879089007627 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 879089007628 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 879089007629 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 879089007630 active site 879089007631 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 879089007632 putative dimer interface [polypeptide binding]; other site 879089007633 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 879089007634 ligand binding site [chemical binding]; other site 879089007635 Zn binding site [ion binding]; other site 879089007636 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 879089007637 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 879089007638 active site 879089007639 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 879089007640 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 879089007641 active site 879089007642 catalytic tetrad [active] 879089007643 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 879089007644 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 879089007645 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 879089007646 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 879089007647 substrate binding pocket [chemical binding]; other site 879089007648 membrane-bound complex binding site; other site 879089007649 hinge residues; other site 879089007650 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 879089007651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089007652 dimer interface [polypeptide binding]; other site 879089007653 conserved gate region; other site 879089007654 putative PBP binding loops; other site 879089007655 ABC-ATPase subunit interface; other site 879089007656 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 879089007657 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 879089007658 Walker A/P-loop; other site 879089007659 ATP binding site [chemical binding]; other site 879089007660 Q-loop/lid; other site 879089007661 ABC transporter signature motif; other site 879089007662 Walker B; other site 879089007663 D-loop; other site 879089007664 H-loop/switch region; other site 879089007665 aspartate aminotransferase; Provisional; Region: PRK06348 879089007666 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 879089007667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089007668 homodimer interface [polypeptide binding]; other site 879089007669 catalytic residue [active] 879089007670 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 879089007671 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089007672 motif II; other site 879089007673 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 879089007674 intracellular protease, PfpI family; Region: PfpI; TIGR01382 879089007675 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 879089007676 proposed catalytic triad [active] 879089007677 conserved cys residue [active] 879089007678 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 879089007679 methionine cluster; other site 879089007680 active site 879089007681 phosphorylation site [posttranslational modification] 879089007682 metal binding site [ion binding]; metal-binding site 879089007683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089007684 Coenzyme A binding pocket [chemical binding]; other site 879089007685 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 879089007686 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 879089007687 esterase; Provisional; Region: PRK10566 879089007688 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 879089007689 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 879089007690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 879089007691 motif II; other site 879089007692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089007693 Uncharacterized conserved protein [Function unknown]; Region: COG1284 879089007694 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 879089007695 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 879089007696 hypothetical protein; Provisional; Region: PRK13673 879089007697 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 879089007698 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 879089007699 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 879089007700 Part of AAA domain; Region: AAA_19; pfam13245 879089007701 Family description; Region: UvrD_C_2; pfam13538 879089007702 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 879089007703 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 879089007704 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 879089007705 IDEAL domain; Region: IDEAL; pfam08858 879089007706 ComK protein; Region: ComK; cl11560 879089007707 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 879089007708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089007709 non-specific DNA binding site [nucleotide binding]; other site 879089007710 salt bridge; other site 879089007711 sequence-specific DNA binding site [nucleotide binding]; other site 879089007712 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 879089007713 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089007714 active site 879089007715 phosphorylation site [posttranslational modification] 879089007716 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 879089007717 active site 879089007718 P-loop; other site 879089007719 phosphorylation site [posttranslational modification] 879089007720 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 879089007721 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 879089007722 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 879089007723 putative substrate binding site [chemical binding]; other site 879089007724 putative ATP binding site [chemical binding]; other site 879089007725 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 879089007726 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 879089007727 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 879089007728 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 879089007729 trimer interface [polypeptide binding]; other site 879089007730 active site 879089007731 G bulge; other site 879089007732 Uncharacterized conserved protein [Function unknown]; Region: COG1683 879089007733 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 879089007734 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 879089007735 non-specific DNA interactions [nucleotide binding]; other site 879089007736 DNA binding site [nucleotide binding] 879089007737 sequence specific DNA binding site [nucleotide binding]; other site 879089007738 putative cAMP binding site [chemical binding]; other site 879089007739 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 879089007740 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 879089007741 substrate binding site [chemical binding]; other site 879089007742 ATP binding site [chemical binding]; other site 879089007743 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 879089007744 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 879089007745 RNA binding surface [nucleotide binding]; other site 879089007746 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 879089007747 active site 879089007748 uracil binding [chemical binding]; other site 879089007749 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 879089007750 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 879089007751 active site 879089007752 non-prolyl cis peptide bond; other site 879089007753 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 879089007754 catalytic residues [active] 879089007755 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 879089007756 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 879089007757 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 879089007758 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 879089007759 Walker A/P-loop; other site 879089007760 ATP binding site [chemical binding]; other site 879089007761 Q-loop/lid; other site 879089007762 ABC transporter signature motif; other site 879089007763 Walker B; other site 879089007764 D-loop; other site 879089007765 H-loop/switch region; other site 879089007766 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 879089007767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089007768 dimer interface [polypeptide binding]; other site 879089007769 conserved gate region; other site 879089007770 putative PBP binding loops; other site 879089007771 ABC-ATPase subunit interface; other site 879089007772 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 879089007773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089007774 dimer interface [polypeptide binding]; other site 879089007775 conserved gate region; other site 879089007776 putative PBP binding loops; other site 879089007777 ABC-ATPase subunit interface; other site 879089007778 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 879089007779 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 879089007780 substrate binding pocket [chemical binding]; other site 879089007781 membrane-bound complex binding site; other site 879089007782 hinge residues; other site 879089007783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089007784 Coenzyme A binding pocket [chemical binding]; other site 879089007785 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 879089007786 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 879089007787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 879089007788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 879089007789 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 879089007790 dimerization interface [polypeptide binding]; other site 879089007791 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 879089007792 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 879089007793 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 879089007794 active site 879089007795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089007796 Major Facilitator Superfamily; Region: MFS_1; pfam07690 879089007797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089007798 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 879089007799 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 879089007800 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 879089007801 active site 879089007802 trimer interface [polypeptide binding]; other site 879089007803 allosteric site; other site 879089007804 active site lid [active] 879089007805 hexamer (dimer of trimers) interface [polypeptide binding]; other site 879089007806 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 879089007807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 879089007808 Predicted membrane protein [Function unknown]; Region: COG1511 879089007809 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 879089007810 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 879089007811 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 879089007812 Predicted transcriptional regulator [Transcription]; Region: COG1959 879089007813 Transcriptional regulator; Region: Rrf2; pfam02082 879089007814 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 879089007815 L-tyrosine decarboxylase; Provisional; Region: PRK13520 879089007816 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 879089007817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089007818 catalytic residue [active] 879089007819 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 879089007820 Mga helix-turn-helix domain; Region: Mga; pfam05043 879089007821 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 879089007822 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 879089007823 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 879089007824 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 879089007825 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 879089007826 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 879089007827 active site 879089007828 dimer interface [polypeptide binding]; other site 879089007829 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 879089007830 dimer interface [polypeptide binding]; other site 879089007831 active site 879089007832 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 879089007833 nudix motif; other site 879089007834 general stress protein 13; Validated; Region: PRK08059 879089007835 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 879089007836 RNA binding site [nucleotide binding]; other site 879089007837 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 879089007838 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 879089007839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089007840 homodimer interface [polypeptide binding]; other site 879089007841 catalytic residue [active] 879089007842 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 879089007843 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 879089007844 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 879089007845 Walker A/P-loop; other site 879089007846 ATP binding site [chemical binding]; other site 879089007847 Q-loop/lid; other site 879089007848 ABC transporter signature motif; other site 879089007849 Walker B; other site 879089007850 D-loop; other site 879089007851 H-loop/switch region; other site 879089007852 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 879089007853 active site 879089007854 P-loop; other site 879089007855 phosphorylation site [posttranslational modification] 879089007856 aspartate kinase; Reviewed; Region: PRK09034 879089007857 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 879089007858 putative catalytic residues [active] 879089007859 putative nucleotide binding site [chemical binding]; other site 879089007860 putative aspartate binding site [chemical binding]; other site 879089007861 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 879089007862 allosteric regulatory residue; other site 879089007863 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 879089007864 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 879089007865 active site 879089007866 drug efflux system protein MdtG; Provisional; Region: PRK09874 879089007867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089007868 putative substrate translocation pore; other site 879089007869 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 879089007870 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 879089007871 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 879089007872 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 879089007873 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 879089007874 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 879089007875 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 879089007876 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 879089007877 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 879089007878 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 879089007879 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 879089007880 CoenzymeA binding site [chemical binding]; other site 879089007881 subunit interaction site [polypeptide binding]; other site 879089007882 PHB binding site; other site 879089007883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 879089007884 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 879089007885 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 879089007886 Cl- selectivity filter; other site 879089007887 Cl- binding residues [ion binding]; other site 879089007888 pore gating glutamate residue; other site 879089007889 dimer interface [polypeptide binding]; other site 879089007890 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089007891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 879089007892 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 879089007893 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 879089007894 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 879089007895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 879089007896 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 879089007897 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 879089007898 NADH(P)-binding; Region: NAD_binding_10; pfam13460 879089007899 NAD(P) binding site [chemical binding]; other site 879089007900 putative active site [active] 879089007901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844 879089007902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 879089007903 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089007904 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089007905 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089007906 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089007907 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089007908 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089007909 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089007910 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089007911 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 879089007912 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 879089007913 tetramer interfaces [polypeptide binding]; other site 879089007914 binuclear metal-binding site [ion binding]; other site 879089007915 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 879089007916 Domain of unknown function DUF21; Region: DUF21; pfam01595 879089007917 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 879089007918 Transporter associated domain; Region: CorC_HlyC; smart01091 879089007919 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 879089007920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089007921 Coenzyme A binding pocket [chemical binding]; other site 879089007922 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 879089007923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089007924 active site 879089007925 motif I; other site 879089007926 motif II; other site 879089007927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089007928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 879089007929 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 879089007930 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 879089007931 active site 879089007932 metal binding site [ion binding]; metal-binding site 879089007933 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 879089007934 Predicted permeases [General function prediction only]; Region: COG0730 879089007935 Predicted membrane protein [Function unknown]; Region: COG4272 879089007936 Uncharacterized conserved protein [Function unknown]; Region: COG1801 879089007937 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 879089007938 FeS assembly protein SufB; Region: sufB; TIGR01980 879089007939 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 879089007940 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 879089007941 trimerization site [polypeptide binding]; other site 879089007942 active site 879089007943 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 879089007944 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 879089007945 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 879089007946 catalytic residue [active] 879089007947 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 879089007948 FeS assembly protein SufD; Region: sufD; TIGR01981 879089007949 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 879089007950 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 879089007951 Walker A/P-loop; other site 879089007952 ATP binding site [chemical binding]; other site 879089007953 Q-loop/lid; other site 879089007954 ABC transporter signature motif; other site 879089007955 Walker B; other site 879089007956 D-loop; other site 879089007957 H-loop/switch region; other site 879089007958 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 879089007959 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 879089007960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089007961 ABC-ATPase subunit interface; other site 879089007962 putative PBP binding loops; other site 879089007963 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 879089007964 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 879089007965 Walker A/P-loop; other site 879089007966 ATP binding site [chemical binding]; other site 879089007967 Q-loop/lid; other site 879089007968 ABC transporter signature motif; other site 879089007969 Walker B; other site 879089007970 D-loop; other site 879089007971 H-loop/switch region; other site 879089007972 NIL domain; Region: NIL; pfam09383 879089007973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 879089007974 dimer interface [polypeptide binding]; other site 879089007975 phosphorylation site [posttranslational modification] 879089007976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089007977 ATP binding site [chemical binding]; other site 879089007978 Mg2+ binding site [ion binding]; other site 879089007979 G-X-G motif; other site 879089007980 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 879089007981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089007982 active site 879089007983 phosphorylation site [posttranslational modification] 879089007984 intermolecular recognition site; other site 879089007985 dimerization interface [polypeptide binding]; other site 879089007986 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 879089007987 DNA binding site [nucleotide binding] 879089007988 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 879089007989 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 879089007990 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 879089007991 catalytic residues [active] 879089007992 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 879089007993 lipoyl attachment site [posttranslational modification]; other site 879089007994 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 879089007995 ArsC family; Region: ArsC; pfam03960 879089007996 putative ArsC-like catalytic residues; other site 879089007997 putative TRX-like catalytic residues [active] 879089007998 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 879089007999 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 879089008000 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 879089008001 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 879089008002 Walker A/P-loop; other site 879089008003 ATP binding site [chemical binding]; other site 879089008004 Q-loop/lid; other site 879089008005 ABC transporter signature motif; other site 879089008006 Walker B; other site 879089008007 D-loop; other site 879089008008 H-loop/switch region; other site 879089008009 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 879089008010 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 879089008011 ABC-ATPase subunit interface; other site 879089008012 dimer interface [polypeptide binding]; other site 879089008013 putative PBP binding regions; other site 879089008014 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 879089008015 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 879089008016 intersubunit interface [polypeptide binding]; other site 879089008017 Predicted esterase [General function prediction only]; Region: COG0627 879089008018 S-formylglutathione hydrolase; Region: PLN02442 879089008019 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 879089008020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089008021 catalytic residue [active] 879089008022 SdpI/YhfL protein family; Region: SdpI; pfam13630 879089008023 CAT RNA binding domain; Region: CAT_RBD; smart01061 879089008024 transcriptional antiterminator BglG; Provisional; Region: PRK09772 879089008025 PRD domain; Region: PRD; pfam00874 879089008026 PRD domain; Region: PRD; pfam00874 879089008027 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 879089008028 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 879089008029 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 879089008030 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 879089008031 Predicted transcriptional regulator [Transcription]; Region: COG2378 879089008032 HTH domain; Region: HTH_11; pfam08279 879089008033 WYL domain; Region: WYL; pfam13280 879089008034 Uncharacterized conserved protein [Function unknown]; Region: COG1434 879089008035 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 879089008036 putative active site [active] 879089008037 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 879089008038 Leucine rich repeat; Region: LRR_8; pfam13855 879089008039 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 879089008040 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 879089008041 active site 879089008042 catalytic site [active] 879089008043 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 879089008044 putative metal binding site [ion binding]; other site 879089008045 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 879089008046 putative metal binding site [ion binding]; other site 879089008047 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 879089008048 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 879089008049 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 879089008050 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 879089008051 active site 879089008052 catalytic site [active] 879089008053 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 879089008054 putative metal binding site [ion binding]; other site 879089008055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089008056 non-specific DNA binding site [nucleotide binding]; other site 879089008057 salt bridge; other site 879089008058 sequence-specific DNA binding site [nucleotide binding]; other site 879089008059 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 879089008060 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 879089008061 SmpB-tmRNA interface; other site 879089008062 ribonuclease R; Region: RNase_R; TIGR02063 879089008063 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 879089008064 RNB domain; Region: RNB; pfam00773 879089008065 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 879089008066 RNA binding site [nucleotide binding]; other site 879089008067 Esterase/lipase [General function prediction only]; Region: COG1647 879089008068 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 879089008069 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 879089008070 Preprotein translocase SecG subunit; Region: SecG; cl09123 879089008071 Esterase/lipase [General function prediction only]; Region: COG1647 879089008072 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 879089008073 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 879089008074 PGAP1-like protein; Region: PGAP1; pfam07819 879089008075 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 879089008076 enolase; Provisional; Region: eno; PRK00077 879089008077 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 879089008078 dimer interface [polypeptide binding]; other site 879089008079 metal binding site [ion binding]; metal-binding site 879089008080 substrate binding pocket [chemical binding]; other site 879089008081 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 879089008082 phosphoglyceromutase; Provisional; Region: PRK05434 879089008083 triosephosphate isomerase; Provisional; Region: PRK14567 879089008084 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 879089008085 substrate binding site [chemical binding]; other site 879089008086 dimer interface [polypeptide binding]; other site 879089008087 catalytic triad [active] 879089008088 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 879089008089 Phosphoglycerate kinase; Region: PGK; pfam00162 879089008090 substrate binding site [chemical binding]; other site 879089008091 hinge regions; other site 879089008092 ADP binding site [chemical binding]; other site 879089008093 catalytic site [active] 879089008094 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 879089008095 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 879089008096 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 879089008097 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 879089008098 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 879089008099 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 879089008100 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 879089008101 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 879089008102 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 879089008103 DNA binding site [nucleotide binding] 879089008104 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 879089008105 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 879089008106 active site 879089008107 dimer interface [polypeptide binding]; other site 879089008108 MMPL family; Region: MMPL; pfam03176 879089008109 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 879089008110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 879089008111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 879089008112 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 879089008113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 879089008114 Chitin binding domain; Region: Chitin_bind_3; pfam03067 879089008115 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 879089008116 Interdomain contacts; other site 879089008117 Cytokine receptor motif; other site 879089008118 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 879089008119 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 879089008120 Interdomain contacts; other site 879089008121 Cytokine receptor motif; other site 879089008122 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 879089008123 aromatic chitin/cellulose binding site residues [chemical binding]; other site 879089008124 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 879089008125 aromatic chitin/cellulose binding site residues [chemical binding]; other site 879089008126 Clp protease; Region: CLP_protease; pfam00574 879089008127 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 879089008128 oligomer interface [polypeptide binding]; other site 879089008129 active site residues [active] 879089008130 amino acid transporter; Region: 2A0306; TIGR00909 879089008131 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 879089008132 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 879089008133 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 879089008134 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089008135 Substrate binding site [chemical binding]; other site 879089008136 Leucine rich repeat; Region: LRR_8; pfam13855 879089008137 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089008138 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 879089008139 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 879089008140 active site 879089008141 FMN binding site [chemical binding]; other site 879089008142 substrate binding site [chemical binding]; other site 879089008143 homotetramer interface [polypeptide binding]; other site 879089008144 catalytic residue [active] 879089008145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 879089008146 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 879089008147 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 879089008148 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 879089008149 phosphate binding site [ion binding]; other site 879089008150 putative substrate binding pocket [chemical binding]; other site 879089008151 dimer interface [polypeptide binding]; other site 879089008152 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 879089008153 AAA domain; Region: AAA_18; pfam13238 879089008154 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 879089008155 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 879089008156 active site 879089008157 substrate binding site [chemical binding]; other site 879089008158 metal binding site [ion binding]; metal-binding site 879089008159 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 879089008160 active site 879089008161 catalytic residues [active] 879089008162 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 879089008163 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 879089008164 NAD binding site [chemical binding]; other site 879089008165 homodimer interface [polypeptide binding]; other site 879089008166 active site 879089008167 substrate binding site [chemical binding]; other site 879089008168 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 879089008169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 879089008170 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 879089008171 TPR repeat; Region: TPR_11; pfam13414 879089008172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 879089008173 binding surface 879089008174 TPR motif; other site 879089008175 Tetratricopeptide repeat; Region: TPR_12; pfam13424 879089008176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 879089008177 binding surface 879089008178 TPR motif; other site 879089008179 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 879089008180 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 879089008181 putative trimer interface [polypeptide binding]; other site 879089008182 putative CoA binding site [chemical binding]; other site 879089008183 pyrophosphatase PpaX; Provisional; Region: PRK13288 879089008184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089008185 motif II; other site 879089008186 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 879089008187 HPr kinase/phosphorylase; Provisional; Region: PRK05428 879089008188 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 879089008189 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 879089008190 Hpr binding site; other site 879089008191 active site 879089008192 homohexamer subunit interaction site [polypeptide binding]; other site 879089008193 Predicted membrane protein [Function unknown]; Region: COG1950 879089008194 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 879089008195 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 879089008196 Uncharacterized conserved protein [Function unknown]; Region: COG3595 879089008197 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 879089008198 Uncharacterized conserved protein [Function unknown]; Region: COG3595 879089008199 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 879089008200 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 879089008201 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 879089008202 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 879089008203 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 879089008204 excinuclease ABC subunit B; Provisional; Region: PRK05298 879089008205 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 879089008206 ATP binding site [chemical binding]; other site 879089008207 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 879089008208 nucleotide binding region [chemical binding]; other site 879089008209 ATP-binding site [chemical binding]; other site 879089008210 Ultra-violet resistance protein B; Region: UvrB; pfam12344 879089008211 UvrB/uvrC motif; Region: UVR; pfam02151 879089008212 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 879089008213 HD containing hydrolase-like enzyme; Region: HD_2; pfam12917 879089008214 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 879089008215 dimerization interface [polypeptide binding]; other site 879089008216 putative DNA binding site [nucleotide binding]; other site 879089008217 putative Zn2+ binding site [ion binding]; other site 879089008218 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 879089008219 PhoU domain; Region: PhoU; pfam01895 879089008220 PhoU domain; Region: PhoU; pfam01895 879089008221 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 879089008222 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 879089008223 Walker A/P-loop; other site 879089008224 ATP binding site [chemical binding]; other site 879089008225 Q-loop/lid; other site 879089008226 ABC transporter signature motif; other site 879089008227 Walker B; other site 879089008228 D-loop; other site 879089008229 H-loop/switch region; other site 879089008230 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 879089008231 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 879089008232 Walker A/P-loop; other site 879089008233 ATP binding site [chemical binding]; other site 879089008234 Q-loop/lid; other site 879089008235 ABC transporter signature motif; other site 879089008236 Walker B; other site 879089008237 D-loop; other site 879089008238 H-loop/switch region; other site 879089008239 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 879089008240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089008241 dimer interface [polypeptide binding]; other site 879089008242 conserved gate region; other site 879089008243 putative PBP binding loops; other site 879089008244 ABC-ATPase subunit interface; other site 879089008245 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 879089008246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089008247 dimer interface [polypeptide binding]; other site 879089008248 conserved gate region; other site 879089008249 putative PBP binding loops; other site 879089008250 ABC-ATPase subunit interface; other site 879089008251 PBP superfamily domain; Region: PBP_like_2; cl17296 879089008252 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 879089008253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 879089008254 HAMP domain; Region: HAMP; pfam00672 879089008255 dimerization interface [polypeptide binding]; other site 879089008256 PAS domain; Region: PAS; smart00091 879089008257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 879089008258 dimer interface [polypeptide binding]; other site 879089008259 phosphorylation site [posttranslational modification] 879089008260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089008261 ATP binding site [chemical binding]; other site 879089008262 Mg2+ binding site [ion binding]; other site 879089008263 G-X-G motif; other site 879089008264 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 879089008265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089008266 active site 879089008267 phosphorylation site [posttranslational modification] 879089008268 intermolecular recognition site; other site 879089008269 dimerization interface [polypeptide binding]; other site 879089008270 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 879089008271 DNA binding site [nucleotide binding] 879089008272 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 879089008273 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 879089008274 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 879089008275 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 879089008276 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 879089008277 putative active site [active] 879089008278 catalytic site [active] 879089008279 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 879089008280 putative active site [active] 879089008281 catalytic site [active] 879089008282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 879089008283 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 879089008284 Peptidase family M23; Region: Peptidase_M23; pfam01551 879089008285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 879089008286 NlpC/P60 family; Region: NLPC_P60; pfam00877 879089008287 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 879089008288 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 879089008289 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 879089008290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089008291 Walker A/P-loop; other site 879089008292 ATP binding site [chemical binding]; other site 879089008293 Q-loop/lid; other site 879089008294 ABC transporter signature motif; other site 879089008295 Walker B; other site 879089008296 D-loop; other site 879089008297 H-loop/switch region; other site 879089008298 Uncharacterized conserved protein [Function unknown]; Region: COG1284 879089008299 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 879089008300 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 879089008301 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 879089008302 peptide chain release factor 2; Validated; Region: prfB; PRK00578 879089008303 This domain is found in peptide chain release factors; Region: PCRF; smart00937 879089008304 RF-1 domain; Region: RF-1; pfam00472 879089008305 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 879089008306 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 879089008307 nucleotide binding region [chemical binding]; other site 879089008308 helicase superfamily c-terminal domain; Region: HELICc; smart00490 879089008309 ATP-binding site [chemical binding]; other site 879089008310 SEC-C motif; Region: SEC-C; pfam02810 879089008311 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 879089008312 30S subunit binding site; other site 879089008313 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 879089008314 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 879089008315 active site 879089008316 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 879089008317 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 879089008318 ATP binding site [chemical binding]; other site 879089008319 putative Mg++ binding site [ion binding]; other site 879089008320 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 879089008321 nucleotide binding region [chemical binding]; other site 879089008322 ATP-binding site [chemical binding]; other site 879089008323 EDD domain protein, DegV family; Region: DegV; TIGR00762 879089008324 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 879089008325 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 879089008326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089008327 active site 879089008328 phosphorylation site [posttranslational modification] 879089008329 intermolecular recognition site; other site 879089008330 dimerization interface [polypeptide binding]; other site 879089008331 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 879089008332 DNA binding residues [nucleotide binding] 879089008333 dimerization interface [polypeptide binding]; other site 879089008334 Uncharacterized conserved protein [Function unknown]; Region: COG1739 879089008335 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 879089008336 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 879089008337 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 879089008338 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 879089008339 Transcriptional regulator [Transcription]; Region: LytR; COG1316 879089008340 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 879089008341 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 879089008342 Mg++ binding site [ion binding]; other site 879089008343 putative catalytic motif [active] 879089008344 substrate binding site [chemical binding]; other site 879089008345 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 879089008346 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 879089008347 active site 879089008348 octamer interface [polypeptide binding]; other site 879089008349 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 879089008350 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 879089008351 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 879089008352 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 879089008353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 879089008354 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 879089008355 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 879089008356 dimer interface [polypeptide binding]; other site 879089008357 ssDNA binding site [nucleotide binding]; other site 879089008358 tetramer (dimer of dimers) interface [polypeptide binding]; other site 879089008359 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 879089008360 rod shape-determining protein Mbl; Provisional; Region: PRK13928 879089008361 MreB and similar proteins; Region: MreB_like; cd10225 879089008362 nucleotide binding site [chemical binding]; other site 879089008363 Mg binding site [ion binding]; other site 879089008364 putative protofilament interaction site [polypeptide binding]; other site 879089008365 RodZ interaction site [polypeptide binding]; other site 879089008366 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 879089008367 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 879089008368 hinge; other site 879089008369 active site 879089008370 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 879089008371 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 879089008372 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 879089008373 gamma subunit interface [polypeptide binding]; other site 879089008374 epsilon subunit interface [polypeptide binding]; other site 879089008375 LBP interface [polypeptide binding]; other site 879089008376 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 879089008377 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 879089008378 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 879089008379 alpha subunit interaction interface [polypeptide binding]; other site 879089008380 Walker A motif; other site 879089008381 ATP binding site [chemical binding]; other site 879089008382 Walker B motif; other site 879089008383 inhibitor binding site; inhibition site 879089008384 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 879089008385 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 879089008386 core domain interface [polypeptide binding]; other site 879089008387 delta subunit interface [polypeptide binding]; other site 879089008388 epsilon subunit interface [polypeptide binding]; other site 879089008389 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 879089008390 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 879089008391 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 879089008392 beta subunit interaction interface [polypeptide binding]; other site 879089008393 Walker A motif; other site 879089008394 ATP binding site [chemical binding]; other site 879089008395 Walker B motif; other site 879089008396 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 879089008397 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 879089008398 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 879089008399 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 879089008400 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 879089008401 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 879089008402 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 879089008403 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 879089008404 ATP synthase I chain; Region: ATP_synt_I; pfam03899 879089008405 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 879089008406 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 879089008407 active site 879089008408 homodimer interface [polypeptide binding]; other site 879089008409 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 879089008410 active site 879089008411 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 879089008412 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 879089008413 dimer interface [polypeptide binding]; other site 879089008414 active site 879089008415 glycine-pyridoxal phosphate binding site [chemical binding]; other site 879089008416 folate binding site [chemical binding]; other site 879089008417 Low molecular weight phosphatase family; Region: LMWPc; cd00115 879089008418 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 879089008419 active site 879089008420 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 879089008421 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 879089008422 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 879089008423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089008424 S-adenosylmethionine binding site [chemical binding]; other site 879089008425 peptide chain release factor 1; Validated; Region: prfA; PRK00591 879089008426 This domain is found in peptide chain release factors; Region: PCRF; smart00937 879089008427 RF-1 domain; Region: RF-1; pfam00472 879089008428 thymidine kinase; Provisional; Region: PRK04296 879089008429 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 879089008430 ATP binding site [chemical binding]; other site 879089008431 Walker A motif; other site 879089008432 Walker B motif; other site 879089008433 homoserine kinase; Provisional; Region: PRK01212 879089008434 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 879089008435 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 879089008436 threonine synthase; Reviewed; Region: PRK06721 879089008437 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 879089008438 homodimer interface [polypeptide binding]; other site 879089008439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089008440 catalytic residue [active] 879089008441 homoserine dehydrogenase; Provisional; Region: PRK06349 879089008442 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 879089008443 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 879089008444 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 879089008445 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 879089008446 Predicted membrane protein [Function unknown]; Region: COG2246 879089008447 GtrA-like protein; Region: GtrA; pfam04138 879089008448 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 879089008449 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 879089008450 Ligand binding site; other site 879089008451 Putative Catalytic site; other site 879089008452 DXD motif; other site 879089008453 transcription termination factor Rho; Provisional; Region: rho; PRK09376 879089008454 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 879089008455 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 879089008456 RNA binding site [nucleotide binding]; other site 879089008457 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 879089008458 multimer interface [polypeptide binding]; other site 879089008459 Walker A motif; other site 879089008460 ATP binding site [chemical binding]; other site 879089008461 Walker B motif; other site 879089008462 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 879089008463 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 879089008464 hinge; other site 879089008465 active site 879089008466 Predicted integral membrane protein [Function unknown]; Region: COG0392 879089008467 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 879089008468 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 879089008469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 879089008470 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 879089008471 putative ADP-binding pocket [chemical binding]; other site 879089008472 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 879089008473 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 879089008474 intersubunit interface [polypeptide binding]; other site 879089008475 active site 879089008476 zinc binding site [ion binding]; other site 879089008477 Na+ binding site [ion binding]; other site 879089008478 putative lipid kinase; Reviewed; Region: PRK13055 879089008479 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 879089008480 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 879089008481 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 879089008482 amidase catalytic site [active] 879089008483 Zn binding residues [ion binding]; other site 879089008484 substrate binding site [chemical binding]; other site 879089008485 SH3-like domain; Region: SH3_8; pfam13457 879089008486 SH3-like domain; Region: SH3_8; pfam13457 879089008487 SH3-like domain; Region: SH3_8; pfam13457 879089008488 SH3-like domain; Region: SH3_8; pfam13457 879089008489 CTP synthetase; Validated; Region: pyrG; PRK05380 879089008490 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 879089008491 Catalytic site [active] 879089008492 active site 879089008493 UTP binding site [chemical binding]; other site 879089008494 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 879089008495 active site 879089008496 putative oxyanion hole; other site 879089008497 catalytic triad [active] 879089008498 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 879089008499 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 879089008500 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 879089008501 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 879089008502 active site 879089008503 HIGH motif; other site 879089008504 KMSK motif region; other site 879089008505 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 879089008506 tRNA binding surface [nucleotide binding]; other site 879089008507 anticodon binding site; other site 879089008508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 879089008509 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 879089008510 Peptidase family M50; Region: Peptidase_M50; pfam02163 879089008511 active site 879089008512 putative substrate binding region [chemical binding]; other site 879089008513 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 879089008514 active site 1 [active] 879089008515 dimer interface [polypeptide binding]; other site 879089008516 hexamer interface [polypeptide binding]; other site 879089008517 active site 2 [active] 879089008518 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 879089008519 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 879089008520 Zn2+ binding site [ion binding]; other site 879089008521 Mg2+ binding site [ion binding]; other site 879089008522 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 879089008523 conserved hypothetical protein TIGR01655; Region: yxeA_fam 879089008524 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 879089008525 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 879089008526 peptide binding site [polypeptide binding]; other site 879089008527 Predicted integral membrane protein [Function unknown]; Region: COG5658 879089008528 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 879089008529 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 879089008530 catalytic triad [active] 879089008531 metal binding site [ion binding]; metal-binding site 879089008532 conserved cis-peptide bond; other site 879089008533 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 879089008534 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 879089008535 folate binding site [chemical binding]; other site 879089008536 NADP+ binding site [chemical binding]; other site 879089008537 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 879089008538 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 879089008539 putative NAD(P) binding site [chemical binding]; other site 879089008540 dimer interface [polypeptide binding]; other site 879089008541 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 879089008542 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 879089008543 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 879089008544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089008545 active site 879089008546 motif I; other site 879089008547 motif II; other site 879089008548 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 879089008549 Uncharacterized conserved protein [Function unknown]; Region: COG1359 879089008550 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 879089008551 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 879089008552 Walker A/P-loop; other site 879089008553 ATP binding site [chemical binding]; other site 879089008554 Q-loop/lid; other site 879089008555 ABC transporter signature motif; other site 879089008556 Walker B; other site 879089008557 D-loop; other site 879089008558 H-loop/switch region; other site 879089008559 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 879089008560 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 879089008561 FtsX-like permease family; Region: FtsX; pfam02687 879089008562 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 879089008563 dimerization interface [polypeptide binding]; other site 879089008564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 879089008565 dimer interface [polypeptide binding]; other site 879089008566 phosphorylation site [posttranslational modification] 879089008567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089008568 ATP binding site [chemical binding]; other site 879089008569 Mg2+ binding site [ion binding]; other site 879089008570 G-X-G motif; other site 879089008571 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 879089008572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089008573 active site 879089008574 phosphorylation site [posttranslational modification] 879089008575 intermolecular recognition site; other site 879089008576 dimerization interface [polypeptide binding]; other site 879089008577 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 879089008578 DNA binding site [nucleotide binding] 879089008579 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 879089008580 Uncharacterized conserved protein [Function unknown]; Region: COG2427 879089008581 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 879089008582 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 879089008583 catalytic loop [active] 879089008584 iron binding site [ion binding]; other site 879089008585 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 879089008586 4Fe-4S binding domain; Region: Fer4; pfam00037 879089008587 4Fe-4S binding domain; Region: Fer4; pfam00037 879089008588 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 879089008589 [4Fe-4S] binding site [ion binding]; other site 879089008590 molybdopterin cofactor binding site; other site 879089008591 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 879089008592 molybdopterin cofactor binding site; other site 879089008593 Uncharacterized conserved protein [Function unknown]; Region: COG1912 879089008594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089008595 Major Facilitator Superfamily; Region: MFS_1; pfam07690 879089008596 putative substrate translocation pore; other site 879089008597 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 879089008598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 879089008599 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 879089008600 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 879089008601 Walker A motif; other site 879089008602 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 879089008603 SH3-like domain; Region: SH3_8; pfam13457 879089008604 SH3-like domain; Region: SH3_8; pfam13457 879089008605 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 879089008606 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 879089008607 active site 879089008608 catalytic tetrad [active] 879089008609 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 879089008610 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 879089008611 DNA binding residues [nucleotide binding] 879089008612 putative dimer interface [polypeptide binding]; other site 879089008613 CRISPR/Cas system-associated protein Csn2; Region: Csn2_like; cl09913 879089008614 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 879089008615 tetramer interface [polypeptide binding]; other site 879089008616 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 879089008617 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 879089008618 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 879089008619 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 879089008620 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 879089008621 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 879089008622 23S rRNA interface [nucleotide binding]; other site 879089008623 L3 interface [polypeptide binding]; other site 879089008624 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 879089008625 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 879089008626 dimerization interface 3.5A [polypeptide binding]; other site 879089008627 active site 879089008628 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 879089008629 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 879089008630 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 879089008631 Walker A/P-loop; other site 879089008632 ATP binding site [chemical binding]; other site 879089008633 Q-loop/lid; other site 879089008634 ABC transporter signature motif; other site 879089008635 Walker B; other site 879089008636 D-loop; other site 879089008637 H-loop/switch region; other site 879089008638 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 879089008639 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 879089008640 Walker A/P-loop; other site 879089008641 ATP binding site [chemical binding]; other site 879089008642 Q-loop/lid; other site 879089008643 ABC transporter signature motif; other site 879089008644 Walker B; other site 879089008645 D-loop; other site 879089008646 H-loop/switch region; other site 879089008647 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 879089008648 MgtC family; Region: MgtC; pfam02308 879089008649 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 879089008650 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 879089008651 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 879089008652 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 879089008653 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 879089008654 alphaNTD - beta interaction site [polypeptide binding]; other site 879089008655 alphaNTD homodimer interface [polypeptide binding]; other site 879089008656 alphaNTD - beta' interaction site [polypeptide binding]; other site 879089008657 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 879089008658 30S ribosomal protein S11; Validated; Region: PRK05309 879089008659 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 879089008660 30S ribosomal protein S13; Region: bact_S13; TIGR03631 879089008661 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 879089008662 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 879089008663 rRNA binding site [nucleotide binding]; other site 879089008664 predicted 30S ribosome binding site; other site 879089008665 adenylate kinase; Reviewed; Region: adk; PRK00279 879089008666 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 879089008667 AMP-binding site [chemical binding]; other site 879089008668 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 879089008669 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 879089008670 SecY translocase; Region: SecY; pfam00344 879089008671 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 879089008672 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 879089008673 23S rRNA binding site [nucleotide binding]; other site 879089008674 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 879089008675 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 879089008676 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 879089008677 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 879089008678 5S rRNA interface [nucleotide binding]; other site 879089008679 L27 interface [polypeptide binding]; other site 879089008680 23S rRNA interface [nucleotide binding]; other site 879089008681 L5 interface [polypeptide binding]; other site 879089008682 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 879089008683 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 879089008684 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 879089008685 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 879089008686 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 879089008687 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 879089008688 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 879089008689 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 879089008690 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 879089008691 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 879089008692 RNA binding site [nucleotide binding]; other site 879089008693 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 879089008694 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 879089008695 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 879089008696 23S rRNA interface [nucleotide binding]; other site 879089008697 putative translocon interaction site; other site 879089008698 signal recognition particle (SRP54) interaction site; other site 879089008699 L23 interface [polypeptide binding]; other site 879089008700 trigger factor interaction site; other site 879089008701 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 879089008702 23S rRNA interface [nucleotide binding]; other site 879089008703 5S rRNA interface [nucleotide binding]; other site 879089008704 putative antibiotic binding site [chemical binding]; other site 879089008705 L25 interface [polypeptide binding]; other site 879089008706 L27 interface [polypeptide binding]; other site 879089008707 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 879089008708 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 879089008709 G-X-X-G motif; other site 879089008710 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 879089008711 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 879089008712 putative translocon binding site; other site 879089008713 protein-rRNA interface [nucleotide binding]; other site 879089008714 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 879089008715 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 879089008716 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 879089008717 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 879089008718 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 879089008719 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 879089008720 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 879089008721 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 879089008722 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 879089008723 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 879089008724 UbiA prenyltransferase family; Region: UbiA; pfam01040 879089008725 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 879089008726 ApbE family; Region: ApbE; pfam02424 879089008727 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 879089008728 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 879089008729 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 879089008730 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 879089008731 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 879089008732 Predicted membrane protein [Function unknown]; Region: COG2259 879089008733 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 879089008734 trimer interface [polypeptide binding]; other site 879089008735 Predicted membrane protein [Function unknown]; Region: COG4769 879089008736 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 879089008737 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 879089008738 substrate binding pocket [chemical binding]; other site 879089008739 chain length determination region; other site 879089008740 substrate-Mg2+ binding site; other site 879089008741 catalytic residues [active] 879089008742 aspartate-rich region 1; other site 879089008743 active site lid residues [active] 879089008744 aspartate-rich region 2; other site 879089008745 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 879089008746 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 879089008747 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 879089008748 active site 879089008749 metal binding site [ion binding]; metal-binding site 879089008750 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 879089008751 hypothetical protein; Provisional; Region: PRK02947 879089008752 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 879089008753 putative active site [active] 879089008754 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 879089008755 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 879089008756 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 879089008757 active site 879089008758 substrate binding pocket [chemical binding]; other site 879089008759 homodimer interaction site [polypeptide binding]; other site 879089008760 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 879089008761 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 879089008762 active site 879089008763 P-loop; other site 879089008764 phosphorylation site [posttranslational modification] 879089008765 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089008766 active site 879089008767 phosphorylation site [posttranslational modification] 879089008768 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 879089008769 Mga helix-turn-helix domain; Region: Mga; pfam05043 879089008770 PRD domain; Region: PRD; pfam00874 879089008771 PRD domain; Region: PRD; pfam00874 879089008772 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 879089008773 active site 879089008774 P-loop; other site 879089008775 phosphorylation site [posttranslational modification] 879089008776 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089008777 active site 879089008778 phosphorylation site [posttranslational modification] 879089008779 elongation factor Tu; Reviewed; Region: PRK00049 879089008780 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 879089008781 G1 box; other site 879089008782 GEF interaction site [polypeptide binding]; other site 879089008783 GTP/Mg2+ binding site [chemical binding]; other site 879089008784 Switch I region; other site 879089008785 G2 box; other site 879089008786 G3 box; other site 879089008787 Switch II region; other site 879089008788 G4 box; other site 879089008789 G5 box; other site 879089008790 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 879089008791 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 879089008792 Antibiotic Binding Site [chemical binding]; other site 879089008793 elongation factor G; Reviewed; Region: PRK00007 879089008794 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 879089008795 G1 box; other site 879089008796 putative GEF interaction site [polypeptide binding]; other site 879089008797 GTP/Mg2+ binding site [chemical binding]; other site 879089008798 Switch I region; other site 879089008799 G2 box; other site 879089008800 G3 box; other site 879089008801 Switch II region; other site 879089008802 G4 box; other site 879089008803 G5 box; other site 879089008804 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 879089008805 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 879089008806 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 879089008807 30S ribosomal protein S7; Validated; Region: PRK05302 879089008808 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 879089008809 S17 interaction site [polypeptide binding]; other site 879089008810 S8 interaction site; other site 879089008811 16S rRNA interaction site [nucleotide binding]; other site 879089008812 streptomycin interaction site [chemical binding]; other site 879089008813 23S rRNA interaction site [nucleotide binding]; other site 879089008814 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 879089008815 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 879089008816 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 879089008817 Zn2+ binding site [ion binding]; other site 879089008818 Mg2+ binding site [ion binding]; other site 879089008819 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 879089008820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089008821 Coenzyme A binding pocket [chemical binding]; other site 879089008822 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 879089008823 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089008824 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089008825 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 879089008826 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 879089008827 substrate binding site [chemical binding]; other site 879089008828 hexamer interface [polypeptide binding]; other site 879089008829 metal binding site [ion binding]; metal-binding site 879089008830 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 879089008831 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 879089008832 TPP-binding site [chemical binding]; other site 879089008833 dimer interface [polypeptide binding]; other site 879089008834 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 879089008835 PYR/PP interface [polypeptide binding]; other site 879089008836 dimer interface [polypeptide binding]; other site 879089008837 TPP binding site [chemical binding]; other site 879089008838 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 879089008839 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 879089008840 substrate binding site [chemical binding]; other site 879089008841 hexamer interface [polypeptide binding]; other site 879089008842 metal binding site [ion binding]; metal-binding site 879089008843 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 879089008844 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 879089008845 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 879089008846 putative NAD(P) binding site [chemical binding]; other site 879089008847 catalytic Zn binding site [ion binding]; other site 879089008848 structural Zn binding site [ion binding]; other site 879089008849 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 879089008850 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 879089008851 putative NAD(P) binding site [chemical binding]; other site 879089008852 catalytic Zn binding site [ion binding]; other site 879089008853 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 879089008854 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 879089008855 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 879089008856 active site 879089008857 P-loop; other site 879089008858 phosphorylation site [posttranslational modification] 879089008859 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089008860 active site 879089008861 phosphorylation site [posttranslational modification] 879089008862 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 879089008863 PRD domain; Region: PRD; pfam00874 879089008864 PRD domain; Region: PRD; pfam00874 879089008865 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 879089008866 active site 879089008867 P-loop; other site 879089008868 phosphorylation site [posttranslational modification] 879089008869 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 879089008870 active site 879089008871 phosphorylation site [posttranslational modification] 879089008872 Predicted membrane protein [Function unknown]; Region: COG4905 879089008873 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 879089008874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 879089008875 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 879089008876 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 879089008877 active site 879089008878 Helix-turn-helix domain; Region: HTH_18; pfam12833 879089008879 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 879089008880 Ligand Binding Site [chemical binding]; other site 879089008881 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 879089008882 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 879089008883 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 879089008884 active site 879089008885 DNA binding site [nucleotide binding] 879089008886 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 879089008887 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 879089008888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 879089008889 active site 879089008890 phosphorylation site [posttranslational modification] 879089008891 intermolecular recognition site; other site 879089008892 dimerization interface [polypeptide binding]; other site 879089008893 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 879089008894 DNA binding site [nucleotide binding] 879089008895 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 879089008896 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 879089008897 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 879089008898 Ligand Binding Site [chemical binding]; other site 879089008899 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 879089008900 GAF domain; Region: GAF_3; pfam13492 879089008901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 879089008902 dimer interface [polypeptide binding]; other site 879089008903 phosphorylation site [posttranslational modification] 879089008904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 879089008905 ATP binding site [chemical binding]; other site 879089008906 Mg2+ binding site [ion binding]; other site 879089008907 G-X-G motif; other site 879089008908 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 879089008909 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 879089008910 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 879089008911 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 879089008912 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 879089008913 active site 879089008914 P-loop; other site 879089008915 phosphorylation site [posttranslational modification] 879089008916 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 879089008917 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 879089008918 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 879089008919 methionine cluster; other site 879089008920 active site 879089008921 phosphorylation site [posttranslational modification] 879089008922 metal binding site [ion binding]; metal-binding site 879089008923 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 879089008924 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 879089008925 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 879089008926 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 879089008927 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 879089008928 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 879089008929 Soluble P-type ATPase [General function prediction only]; Region: COG4087 879089008930 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 879089008931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 879089008932 autolysin; Reviewed; Region: PRK06347 879089008933 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 879089008934 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 879089008935 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 879089008936 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 879089008937 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 879089008938 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 879089008939 catalytic residues [active] 879089008940 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 879089008941 catalytic residues [active] 879089008942 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 879089008943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089008944 Walker A/P-loop; other site 879089008945 ATP binding site [chemical binding]; other site 879089008946 Q-loop/lid; other site 879089008947 ABC transporter signature motif; other site 879089008948 Walker B; other site 879089008949 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 879089008950 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 879089008951 putative active site [active] 879089008952 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 879089008953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089008954 Walker A/P-loop; other site 879089008955 ATP binding site [chemical binding]; other site 879089008956 Q-loop/lid; other site 879089008957 ABC transporter signature motif; other site 879089008958 Walker B; other site 879089008959 D-loop; other site 879089008960 H-loop/switch region; other site 879089008961 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 879089008962 putative metal binding site; other site 879089008963 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 879089008964 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 879089008965 Protein of unknown function (DUF970); Region: DUF970; pfam06153 879089008966 thymidylate kinase; Validated; Region: tmk; PRK00698 879089008967 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 879089008968 TMP-binding site; other site 879089008969 ATP-binding site [chemical binding]; other site 879089008970 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 879089008971 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 879089008972 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 879089008973 catalytic residue [active] 879089008974 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 879089008975 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 879089008976 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 879089008977 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 879089008978 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 879089008979 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 879089008980 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 879089008981 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 879089008982 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 879089008983 putative active site [active] 879089008984 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 879089008985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089008986 active site 879089008987 motif I; other site 879089008988 motif II; other site 879089008989 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 879089008990 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089008991 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089008992 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089008993 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089008994 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089008995 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089008996 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089008997 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 879089008998 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 879089008999 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 879089009000 active site 879089009001 catalytic tetrad [active] 879089009002 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 879089009003 recombination protein RecR; Reviewed; Region: recR; PRK00076 879089009004 RecR protein; Region: RecR; pfam02132 879089009005 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 879089009006 putative active site [active] 879089009007 putative metal-binding site [ion binding]; other site 879089009008 tetramer interface [polypeptide binding]; other site 879089009009 hypothetical protein; Validated; Region: PRK00153 879089009010 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 879089009011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 879089009012 Walker A motif; other site 879089009013 ATP binding site [chemical binding]; other site 879089009014 Walker B motif; other site 879089009015 arginine finger; other site 879089009016 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 879089009017 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 879089009018 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 879089009019 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 879089009020 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 879089009021 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 879089009022 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 879089009023 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 879089009024 N- and C-terminal domain interface [polypeptide binding]; other site 879089009025 active site 879089009026 catalytic site [active] 879089009027 metal binding site [ion binding]; metal-binding site 879089009028 carbohydrate binding site [chemical binding]; other site 879089009029 ATP binding site [chemical binding]; other site 879089009030 SH3-like domain; Region: SH3_8; pfam13457 879089009031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 879089009032 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 879089009033 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 879089009034 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 879089009035 Walker A/P-loop; other site 879089009036 ATP binding site [chemical binding]; other site 879089009037 Q-loop/lid; other site 879089009038 ABC transporter signature motif; other site 879089009039 Walker B; other site 879089009040 D-loop; other site 879089009041 H-loop/switch region; other site 879089009042 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 879089009043 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 879089009044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089009045 Walker A/P-loop; other site 879089009046 ATP binding site [chemical binding]; other site 879089009047 Q-loop/lid; other site 879089009048 ABC transporter signature motif; other site 879089009049 Walker B; other site 879089009050 D-loop; other site 879089009051 H-loop/switch region; other site 879089009052 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 879089009053 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 879089009054 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 879089009055 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 879089009056 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 879089009057 nucleoside/Zn binding site; other site 879089009058 dimer interface [polypeptide binding]; other site 879089009059 catalytic motif [active] 879089009060 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 879089009061 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 879089009062 active site 879089009063 acyl-activating enzyme (AAE) consensus motif; other site 879089009064 putative CoA binding site [chemical binding]; other site 879089009065 AMP binding site [chemical binding]; other site 879089009066 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 879089009067 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 879089009068 active site 879089009069 trimer interface [polypeptide binding]; other site 879089009070 allosteric site; other site 879089009071 active site lid [active] 879089009072 hexamer (dimer of trimers) interface [polypeptide binding]; other site 879089009073 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 879089009074 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 879089009075 DNA binding residues [nucleotide binding] 879089009076 drug binding residues [chemical binding]; other site 879089009077 dimer interface [polypeptide binding]; other site 879089009078 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 879089009079 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 879089009080 Coenzyme A binding pocket [chemical binding]; other site 879089009081 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 879089009082 dimer interface [polypeptide binding]; other site 879089009083 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 879089009084 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 879089009085 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 879089009086 MarR family; Region: MarR; pfam01047 879089009087 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 879089009088 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 879089009089 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 879089009090 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 879089009091 DNA binding residues [nucleotide binding] 879089009092 putative dimer interface [polypeptide binding]; other site 879089009093 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 879089009094 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 879089009095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089009096 active site 879089009097 motif I; other site 879089009098 motif II; other site 879089009099 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 879089009100 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 879089009101 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 879089009102 putative active site [active] 879089009103 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 879089009104 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089009105 active site 879089009106 phosphorylation site [posttranslational modification] 879089009107 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 879089009108 active site 879089009109 P-loop; other site 879089009110 phosphorylation site [posttranslational modification] 879089009111 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 879089009112 alpha-mannosidase; Provisional; Region: PRK09819 879089009113 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 879089009114 active site 879089009115 catalytic site [active] 879089009116 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 879089009117 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 879089009118 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 879089009119 active site 879089009120 homodimer interface [polypeptide binding]; other site 879089009121 catalytic site [active] 879089009122 glycerate kinase; Region: TIGR00045 879089009123 Transcriptional regulators [Transcription]; Region: PurR; COG1609 879089009124 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 879089009125 DNA binding site [nucleotide binding] 879089009126 domain linker motif; other site 879089009127 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 879089009128 putative dimerization interface [polypeptide binding]; other site 879089009129 putative ligand binding site [chemical binding]; other site 879089009130 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 879089009131 Domain of unknown function DUF21; Region: DUF21; pfam01595 879089009132 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 879089009133 Transporter associated domain; Region: CorC_HlyC; pfam03471 879089009134 NAD-dependent deacetylase; Provisional; Region: PRK00481 879089009135 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 879089009136 NAD+ binding site [chemical binding]; other site 879089009137 substrate binding site [chemical binding]; other site 879089009138 putative Zn binding site [ion binding]; other site 879089009139 Pathogenicity locus; Region: Cdd1; pfam11731 879089009140 drug efflux system protein MdtG; Provisional; Region: PRK09874 879089009141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089009142 putative substrate translocation pore; other site 879089009143 Variant SH3 domain; Region: SH3_2; pfam07653 879089009144 Variant SH3 domain; Region: SH3_2; pfam07653 879089009145 peptide ligand binding site [polypeptide binding]; other site 879089009146 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 879089009147 active site 879089009148 intersubunit interactions; other site 879089009149 catalytic residue [active] 879089009150 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 879089009151 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 879089009152 ligand binding site [chemical binding]; other site 879089009153 flexible hinge region; other site 879089009154 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 879089009155 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 879089009156 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 879089009157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089009158 Walker A/P-loop; other site 879089009159 ATP binding site [chemical binding]; other site 879089009160 Q-loop/lid; other site 879089009161 ABC transporter signature motif; other site 879089009162 Walker B; other site 879089009163 D-loop; other site 879089009164 H-loop/switch region; other site 879089009165 TfoX C-terminal domain; Region: TfoX_C; pfam04994 879089009166 seryl-tRNA synthetase; Provisional; Region: PRK05431 879089009167 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 879089009168 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 879089009169 dimer interface [polypeptide binding]; other site 879089009170 active site 879089009171 motif 1; other site 879089009172 motif 2; other site 879089009173 motif 3; other site 879089009174 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 879089009175 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 879089009176 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 879089009177 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 879089009178 glutamine binding [chemical binding]; other site 879089009179 catalytic triad [active] 879089009180 aminodeoxychorismate synthase; Provisional; Region: PRK07508 879089009181 chorismate binding enzyme; Region: Chorismate_bind; cl10555 879089009182 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 879089009183 substrate-cofactor binding pocket; other site 879089009184 homodimer interface [polypeptide binding]; other site 879089009185 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 879089009186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 879089009187 catalytic residue [active] 879089009188 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 879089009189 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 879089009190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089009191 Walker A/P-loop; other site 879089009192 ATP binding site [chemical binding]; other site 879089009193 Q-loop/lid; other site 879089009194 ABC transporter signature motif; other site 879089009195 Walker B; other site 879089009196 D-loop; other site 879089009197 H-loop/switch region; other site 879089009198 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 879089009199 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 879089009200 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 879089009201 Walker A/P-loop; other site 879089009202 ATP binding site [chemical binding]; other site 879089009203 Q-loop/lid; other site 879089009204 ABC transporter signature motif; other site 879089009205 Walker B; other site 879089009206 D-loop; other site 879089009207 H-loop/switch region; other site 879089009208 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 879089009209 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 879089009210 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 879089009211 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 879089009212 Predicted acyl esterases [General function prediction only]; Region: COG2936 879089009213 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 879089009214 DNA topoisomerase III; Provisional; Region: PRK07726 879089009215 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 879089009216 active site 879089009217 putative interdomain interaction site [polypeptide binding]; other site 879089009218 putative metal-binding site [ion binding]; other site 879089009219 putative nucleotide binding site [chemical binding]; other site 879089009220 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 879089009221 domain I; other site 879089009222 DNA binding groove [nucleotide binding] 879089009223 phosphate binding site [ion binding]; other site 879089009224 domain II; other site 879089009225 domain III; other site 879089009226 nucleotide binding site [chemical binding]; other site 879089009227 catalytic site [active] 879089009228 domain IV; other site 879089009229 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 879089009230 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 879089009231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 879089009232 ATP binding site [chemical binding]; other site 879089009233 putative Mg++ binding site [ion binding]; other site 879089009234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 879089009235 nucleotide binding region [chemical binding]; other site 879089009236 ATP-binding site [chemical binding]; other site 879089009237 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 879089009238 HRDC domain; Region: HRDC; pfam00570 879089009239 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 879089009240 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 879089009241 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 879089009242 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 879089009243 active site 879089009244 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 879089009245 putative ADP-ribose binding site [chemical binding]; other site 879089009246 putative active site [active] 879089009247 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 879089009248 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 879089009249 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 879089009250 ABC transporter; Region: ABC_tran_2; pfam12848 879089009251 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 879089009252 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 879089009253 beta-galactosidase; Region: BGL; TIGR03356 879089009254 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 879089009255 active site 879089009256 P-loop; other site 879089009257 phosphorylation site [posttranslational modification] 879089009258 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 879089009259 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 879089009260 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 879089009261 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 879089009262 nucleotide binding site [chemical binding]; other site 879089009263 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 879089009264 methionine cluster; other site 879089009265 active site 879089009266 phosphorylation site [posttranslational modification] 879089009267 metal binding site [ion binding]; metal-binding site 879089009268 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 879089009269 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 879089009270 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 879089009271 putative active site [active] 879089009272 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 879089009273 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 879089009274 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 879089009275 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 879089009276 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 879089009277 Walker A/P-loop; other site 879089009278 ATP binding site [chemical binding]; other site 879089009279 Q-loop/lid; other site 879089009280 ABC transporter signature motif; other site 879089009281 Walker B; other site 879089009282 D-loop; other site 879089009283 H-loop/switch region; other site 879089009284 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 879089009285 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 879089009286 ATP-grasp domain; Region: ATP-grasp_4; cl17255 879089009287 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 879089009288 beta-galactosidase; Region: BGL; TIGR03356 879089009289 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 879089009290 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 879089009291 active site turn [active] 879089009292 phosphorylation site [posttranslational modification] 879089009293 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 879089009294 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 879089009295 HPr interaction site; other site 879089009296 glycerol kinase (GK) interaction site [polypeptide binding]; other site 879089009297 active site 879089009298 phosphorylation site [posttranslational modification] 879089009299 transcriptional antiterminator BglG; Provisional; Region: PRK09772 879089009300 CAT RNA binding domain; Region: CAT_RBD; smart01061 879089009301 PRD domain; Region: PRD; pfam00874 879089009302 PRD domain; Region: PRD; pfam00874 879089009303 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 879089009304 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 879089009305 Walker A/P-loop; other site 879089009306 ATP binding site [chemical binding]; other site 879089009307 Q-loop/lid; other site 879089009308 ABC transporter signature motif; other site 879089009309 Walker B; other site 879089009310 D-loop; other site 879089009311 H-loop/switch region; other site 879089009312 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 879089009313 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 879089009314 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 879089009315 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 879089009316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089009317 putative substrate translocation pore; other site 879089009318 GTP-binding protein YchF; Reviewed; Region: PRK09601 879089009319 YchF GTPase; Region: YchF; cd01900 879089009320 G1 box; other site 879089009321 GTP/Mg2+ binding site [chemical binding]; other site 879089009322 Switch I region; other site 879089009323 G2 box; other site 879089009324 Switch II region; other site 879089009325 G3 box; other site 879089009326 G4 box; other site 879089009327 G5 box; other site 879089009328 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 879089009329 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 879089009330 methionine cluster; other site 879089009331 active site 879089009332 phosphorylation site [posttranslational modification] 879089009333 metal binding site [ion binding]; metal-binding site 879089009334 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 879089009335 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 879089009336 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 879089009337 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 879089009338 active site 879089009339 P-loop; other site 879089009340 phosphorylation site [posttranslational modification] 879089009341 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 879089009342 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 879089009343 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 879089009344 HTH domain; Region: HTH_11; pfam08279 879089009345 Mga helix-turn-helix domain; Region: Mga; pfam05043 879089009346 PRD domain; Region: PRD; pfam00874 879089009347 PRD domain; Region: PRD; pfam00874 879089009348 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 879089009349 active site 879089009350 P-loop; other site 879089009351 phosphorylation site [posttranslational modification] 879089009352 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089009353 active site 879089009354 phosphorylation site [posttranslational modification] 879089009355 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 879089009356 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 879089009357 tetramer interface [polypeptide binding]; other site 879089009358 heme binding pocket [chemical binding]; other site 879089009359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 879089009360 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 879089009361 ParB-like nuclease domain; Region: ParB; smart00470 879089009362 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 879089009363 salt bridge; other site 879089009364 non-specific DNA binding site [nucleotide binding]; other site 879089009365 sequence-specific DNA binding site [nucleotide binding]; other site 879089009366 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 879089009367 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 879089009368 P-loop; other site 879089009369 Magnesium ion binding site [ion binding]; other site 879089009370 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 879089009371 Magnesium ion binding site [ion binding]; other site 879089009372 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 879089009373 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 879089009374 non-specific DNA binding site [nucleotide binding]; other site 879089009375 salt bridge; other site 879089009376 sequence-specific DNA binding site [nucleotide binding]; other site 879089009377 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 879089009378 ParB-like nuclease domain; Region: ParBc; pfam02195 879089009379 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 879089009380 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 879089009381 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 879089009382 putative active site [active] 879089009383 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 879089009384 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 879089009385 nucleotide binding site [chemical binding]; other site 879089009386 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 879089009387 active site 879089009388 phosphorylation site [posttranslational modification] 879089009389 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 879089009390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089009391 motif II; other site 879089009392 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 879089009393 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 879089009394 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 879089009395 active site 879089009396 P-loop; other site 879089009397 phosphorylation site [posttranslational modification] 879089009398 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 879089009399 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 879089009400 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 879089009401 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 879089009402 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 879089009403 putative active site cavity [active] 879089009404 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 879089009405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 879089009406 S-adenosylmethionine binding site [chemical binding]; other site 879089009407 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 879089009408 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 879089009409 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 879089009410 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 879089009411 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 879089009412 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 879089009413 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 879089009414 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 879089009415 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 879089009416 trmE is a tRNA modification GTPase; Region: trmE; cd04164 879089009417 G1 box; other site 879089009418 GTP/Mg2+ binding site [chemical binding]; other site 879089009419 Switch I region; other site 879089009420 G2 box; other site 879089009421 Switch II region; other site 879089009422 G3 box; other site 879089009423 G4 box; other site 879089009424 G5 box; other site 879089009425 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 879089009426 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 879089009427 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 879089009428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 879089009429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 879089009430 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 879089009431 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 879089009432 NADP binding site [chemical binding]; other site 879089009433 homodimer interface [polypeptide binding]; other site 879089009434 active site 879089009435 substrate binding site [chemical binding]; other site 879089009436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089009437 D-galactonate transporter; Region: 2A0114; TIGR00893 879089009438 putative substrate translocation pore; other site 879089009439 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 879089009440 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 879089009441 metal binding site [ion binding]; metal-binding site 879089009442 dimer interface [polypeptide binding]; other site 879089009443 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 879089009444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 879089009445 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 879089009446 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 879089009447 metal binding site [ion binding]; metal-binding site 879089009448 dimer interface [polypeptide binding]; other site 879089009449 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 879089009450 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 879089009451 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 879089009452 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 879089009453 Leucine-rich repeats; other site 879089009454 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089009455 Substrate binding site [chemical binding]; other site 879089009456 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 879089009457 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089009458 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089009459 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089009460 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089009461 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 879089009462 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 879089009463 Uncharacterized conserved protein [Function unknown]; Region: COG4198 879089009464 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 879089009465 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 879089009466 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 879089009467 putative ligand binding site [chemical binding]; other site 879089009468 putative NAD binding site [chemical binding]; other site 879089009469 putative catalytic site [active] 879089009470 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 879089009471 L-serine binding site [chemical binding]; other site 879089009472 ACT domain interface; other site 879089009473 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 879089009474 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 879089009475 catalytic residue [active] 879089009476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089009477 Major Facilitator Superfamily; Region: MFS_1; pfam07690 879089009478 putative substrate translocation pore; other site 879089009479 Transcriptional regulators [Transcription]; Region: MarR; COG1846 879089009480 MarR family; Region: MarR_2; pfam12802 879089009481 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 879089009482 dimer interface [polypeptide binding]; other site 879089009483 FMN binding site [chemical binding]; other site 879089009484 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 879089009485 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 879089009486 catalytic residues [active] 879089009487 beta-phosphoglucomutase; Region: bPGM; TIGR01990 879089009488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 879089009489 motif II; other site 879089009490 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 879089009491 Glycerate kinase family; Region: Gly_kinase; cl00841 879089009492 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 879089009493 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 879089009494 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 879089009495 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 879089009496 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 879089009497 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 879089009498 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 879089009499 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 879089009500 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 879089009501 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 879089009502 putative NAD(P) binding site [chemical binding]; other site 879089009503 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 879089009504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089009505 dimer interface [polypeptide binding]; other site 879089009506 conserved gate region; other site 879089009507 putative PBP binding loops; other site 879089009508 ABC-ATPase subunit interface; other site 879089009509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 879089009510 dimer interface [polypeptide binding]; other site 879089009511 conserved gate region; other site 879089009512 putative PBP binding loops; other site 879089009513 ABC-ATPase subunit interface; other site 879089009514 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 879089009515 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 879089009516 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 879089009517 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 879089009518 active site 879089009519 homodimer interface [polypeptide binding]; other site 879089009520 catalytic site [active] 879089009521 Transcriptional regulators [Transcription]; Region: PurR; COG1609 879089009522 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 879089009523 DNA binding site [nucleotide binding] 879089009524 domain linker motif; other site 879089009525 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 879089009526 putative dimerization interface [polypeptide binding]; other site 879089009527 putative ligand binding site [chemical binding]; other site 879089009528 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 879089009529 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 879089009530 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 879089009531 Coenzyme A binding pocket [chemical binding]; other site 879089009532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089009533 Major Facilitator Superfamily; Region: MFS_1; pfam07690 879089009534 putative substrate translocation pore; other site 879089009535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089009536 Domain of unknown function (DUF718); Region: DUF718; cl01281 879089009537 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 879089009538 intersubunit interface [polypeptide binding]; other site 879089009539 active site 879089009540 Zn2+ binding site [ion binding]; other site 879089009541 L-rhamnose isomerase; Provisional; Region: PRK01076 879089009542 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 879089009543 N- and C-terminal domain interface [polypeptide binding]; other site 879089009544 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 879089009545 active site 879089009546 putative catalytic site [active] 879089009547 metal binding site [ion binding]; metal-binding site 879089009548 ATP binding site [chemical binding]; other site 879089009549 carbohydrate binding site [chemical binding]; other site 879089009550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 879089009551 putative substrate translocation pore; other site 879089009552 Major Facilitator Superfamily; Region: MFS_1; pfam07690 879089009553 Cupin domain; Region: Cupin_2; pfam07883 879089009554 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 879089009555 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 879089009556 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 879089009557 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 879089009558 G-X-X-G motif; other site 879089009559 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 879089009560 RxxxH motif; other site 879089009561 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 879089009562 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 879089009563 ribonuclease P; Reviewed; Region: rnpA; PRK00499 879089009564 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399