-- dump date 20140619_133816 -- class Genbank::misc_feature -- table misc_feature_note -- id note 932919000001 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 932919000002 Integrase core domain; Region: rve; pfam00665 932919000003 Integrase core domain; Region: rve_3; pfam13683 932919000004 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 932919000005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919000006 Walker A motif; other site 932919000007 ATP binding site [chemical binding]; other site 932919000008 Walker B motif; other site 932919000009 arginine finger; other site 932919000010 potential frameshift: common BLAST hit: gi|298740848|ref|YP_003727985.1| transposase element 932919000011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 932919000012 Integrase core domain; Region: rve; pfam00665 932919000013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 932919000014 Fic family protein [Function unknown]; Region: COG3177 932919000015 Fic/DOC family; Region: Fic; pfam02661 932919000016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919000017 non-specific DNA binding site [nucleotide binding]; other site 932919000018 salt bridge; other site 932919000019 sequence-specific DNA binding site [nucleotide binding]; other site 932919000020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 932919000021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 932919000022 Integrase core domain; Region: rve; pfam00665 932919000023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 932919000024 Integrase core domain; Region: rve; pfam00665 932919000025 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 932919000026 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932919000027 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 932919000028 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 932919000029 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 932919000030 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 932919000031 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 932919000032 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932919000033 Soluble P-type ATPase [General function prediction only]; Region: COG4087 932919000034 Integrase core domain; Region: rve; pfam00665 932919000035 DDE domain; Region: DDE_Tnp_IS240; pfam13610 932919000036 Domain of unknown function DUF87; Region: DUF87; pfam01935 932919000037 HerA helicase [Replication, recombination, and repair]; Region: COG0433 932919000038 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 932919000039 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 932919000040 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 932919000041 catalytic residues [active] 932919000042 catalytic nucleophile [active] 932919000043 Presynaptic Site I dimer interface [polypeptide binding]; other site 932919000044 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 932919000045 Synaptic Flat tetramer interface [polypeptide binding]; other site 932919000046 Synaptic Site I dimer interface [polypeptide binding]; other site 932919000047 DNA binding site [nucleotide binding] 932919000048 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 932919000049 DNA-binding interface [nucleotide binding]; DNA binding site 932919000050 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 932919000051 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932919000052 Soluble P-type ATPase [General function prediction only]; Region: COG4087 932919000053 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 932919000054 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 932919000055 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 932919000056 multiple promoter invertase; Provisional; Region: mpi; PRK13413 932919000057 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 932919000058 catalytic residues [active] 932919000059 catalytic nucleophile [active] 932919000060 Presynaptic Site I dimer interface [polypeptide binding]; other site 932919000061 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 932919000062 Synaptic Flat tetramer interface [polypeptide binding]; other site 932919000063 Synaptic Site I dimer interface [polypeptide binding]; other site 932919000064 DNA binding site [nucleotide binding] 932919000065 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 932919000066 DNA-binding interface [nucleotide binding]; DNA binding site 932919000067 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932919000068 dimerization interface [polypeptide binding]; other site 932919000069 putative DNA binding site [nucleotide binding]; other site 932919000070 putative Zn2+ binding site [ion binding]; other site 932919000071 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 932919000072 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 932919000073 metal-binding site [ion binding] 932919000074 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932919000075 Soluble P-type ATPase [General function prediction only]; Region: COG4087 932919000076 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 932919000077 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 932919000078 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 932919000079 AP2 domain; Region: AP2; pfam00847 932919000080 putative transposase OrfB; Reviewed; Region: PHA02517 932919000081 HTH-like domain; Region: HTH_21; pfam13276 932919000082 Integrase core domain; Region: rve; pfam00665 932919000083 Integrase core domain; Region: rve_3; pfam13683 932919000084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 932919000085 Transposase; Region: HTH_Tnp_1; cl17663 932919000086 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 932919000087 multiple promoter invertase; Provisional; Region: mpi; PRK13413 932919000088 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 932919000089 catalytic residues [active] 932919000090 catalytic nucleophile [active] 932919000091 Presynaptic Site I dimer interface [polypeptide binding]; other site 932919000092 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 932919000093 Synaptic Flat tetramer interface [polypeptide binding]; other site 932919000094 Synaptic Site I dimer interface [polypeptide binding]; other site 932919000095 DNA binding site [nucleotide binding] 932919000096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919000097 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 932919000098 Walker A motif; other site 932919000099 ATP binding site [chemical binding]; other site 932919000100 Walker B motif; other site 932919000101 arginine finger; other site 932919000102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919000103 Walker A motif; other site 932919000104 ATP binding site [chemical binding]; other site 932919000105 Walker B motif; other site 932919000106 arginine finger; other site 932919000107 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 932919000108 Helix-turn-helix domain; Region: HTH_28; pfam13518 932919000109 putative transposase OrfB; Reviewed; Region: PHA02517 932919000110 HTH-like domain; Region: HTH_21; pfam13276 932919000111 Integrase core domain; Region: rve; pfam00665 932919000112 Integrase core domain; Region: rve_3; pfam13683 932919000113 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 932919000114 P-loop; other site 932919000115 Magnesium ion binding site [ion binding]; other site 932919000116 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 932919000117 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 932919000118 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 932919000119 active site 932919000120 DNA binding site [nucleotide binding] 932919000121 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 932919000122 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 932919000123 P-loop; other site 932919000124 Magnesium ion binding site [ion binding]; other site 932919000125 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 932919000126 Magnesium ion binding site [ion binding]; other site 932919000127 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 932919000128 DnaA N-terminal domain; Region: DnaA_N; pfam11638 932919000129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919000130 Walker A motif; other site 932919000131 ATP binding site [chemical binding]; other site 932919000132 Walker B motif; other site 932919000133 arginine finger; other site 932919000134 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 932919000135 DnaA box-binding interface [nucleotide binding]; other site 932919000136 DNA polymerase III subunit beta; Validated; Region: PRK05643 932919000137 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 932919000138 putative DNA binding surface [nucleotide binding]; other site 932919000139 dimer interface [polypeptide binding]; other site 932919000140 beta-clamp/clamp loader binding surface; other site 932919000141 beta-clamp/translesion DNA polymerase binding surface; other site 932919000142 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 932919000143 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 932919000144 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 932919000145 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 932919000146 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 932919000147 Walker A/P-loop; other site 932919000148 ATP binding site [chemical binding]; other site 932919000149 Q-loop/lid; other site 932919000150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919000151 ABC transporter signature motif; other site 932919000152 Walker B; other site 932919000153 D-loop; other site 932919000154 H-loop/switch region; other site 932919000155 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 932919000156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919000157 Mg2+ binding site [ion binding]; other site 932919000158 G-X-G motif; other site 932919000159 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 932919000160 anchoring element; other site 932919000161 dimer interface [polypeptide binding]; other site 932919000162 ATP binding site [chemical binding]; other site 932919000163 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 932919000164 active site 932919000165 putative metal-binding site [ion binding]; other site 932919000166 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 932919000167 DNA gyrase subunit A; Validated; Region: PRK05560 932919000168 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 932919000169 CAP-like domain; other site 932919000170 active site 932919000171 primary dimer interface [polypeptide binding]; other site 932919000172 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932919000173 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932919000174 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932919000175 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932919000176 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932919000177 cardiolipin synthetase; Reviewed; Region: PRK12452 932919000178 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 932919000179 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 932919000180 putative active site [active] 932919000181 catalytic site [active] 932919000182 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 932919000183 putative active site [active] 932919000184 catalytic site [active] 932919000185 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 932919000186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919000187 Coenzyme A binding pocket [chemical binding]; other site 932919000188 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 932919000189 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 932919000190 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 932919000191 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 932919000192 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 932919000193 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 932919000194 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 932919000195 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 932919000196 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 932919000197 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 932919000198 D-pathway; other site 932919000199 Putative ubiquinol binding site [chemical binding]; other site 932919000200 Low-spin heme (heme b) binding site [chemical binding]; other site 932919000201 Putative water exit pathway; other site 932919000202 Binuclear center (heme o3/CuB) [ion binding]; other site 932919000203 K-pathway; other site 932919000204 Putative proton exit pathway; other site 932919000205 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 932919000206 Subunit I/III interface [polypeptide binding]; other site 932919000207 Subunit III/IV interface [polypeptide binding]; other site 932919000208 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 932919000209 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 932919000210 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 932919000211 putative active site [active] 932919000212 putative metal binding site [ion binding]; other site 932919000213 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 932919000214 beta-galactosidase; Region: BGL; TIGR03356 932919000215 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 932919000216 Bacterial SH3 domain; Region: SH3_3; pfam08239 932919000217 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 932919000218 putative active site [active] 932919000219 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932919000220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919000221 DNA-binding site [nucleotide binding]; DNA binding site 932919000222 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 932919000223 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 932919000224 active site 932919000225 active pocket/dimerization site; other site 932919000226 phosphorylation site [posttranslational modification] 932919000227 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 932919000228 active site 932919000229 phosphorylation site [posttranslational modification] 932919000230 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 932919000231 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 932919000232 hypothetical protein; Provisional; Region: PRK02947 932919000233 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932919000234 putative active site [active] 932919000235 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 932919000236 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 932919000237 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932919000238 active site turn [active] 932919000239 phosphorylation site [posttranslational modification] 932919000240 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932919000241 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 932919000242 HPr interaction site; other site 932919000243 glycerol kinase (GK) interaction site [polypeptide binding]; other site 932919000244 active site 932919000245 phosphorylation site [posttranslational modification] 932919000246 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 932919000247 putative dimer interface [polypeptide binding]; other site 932919000248 catalytic triad [active] 932919000249 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932919000250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919000251 Walker A/P-loop; other site 932919000252 ATP binding site [chemical binding]; other site 932919000253 Q-loop/lid; other site 932919000254 ABC transporter signature motif; other site 932919000255 Walker B; other site 932919000256 D-loop; other site 932919000257 H-loop/switch region; other site 932919000258 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 932919000259 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 932919000260 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932919000261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919000262 active site 932919000263 motif I; other site 932919000264 motif II; other site 932919000265 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919000266 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932919000267 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932919000268 DNA binding site [nucleotide binding] 932919000269 domain linker motif; other site 932919000270 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 932919000271 dimerization interface [polypeptide binding]; other site 932919000272 putative ligand binding site [chemical binding]; other site 932919000273 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932919000274 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932919000275 nucleotide binding site [chemical binding]; other site 932919000276 Butyrate kinase [Energy production and conversion]; Region: COG3426 932919000277 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 932919000278 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 932919000279 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932919000280 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932919000281 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 932919000282 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 932919000283 dimer interface [polypeptide binding]; other site 932919000284 active site 932919000285 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 932919000286 dimer interface [polypeptide binding]; other site 932919000287 active site 932919000288 putrescine carbamoyltransferase; Provisional; Region: PRK02255 932919000289 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 932919000290 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 932919000291 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 932919000292 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 932919000293 agmatine deiminase; Provisional; Region: PRK13551 932919000294 agmatine deiminase; Region: agmatine_aguA; TIGR03380 932919000295 carbamate kinase; Reviewed; Region: PRK12686 932919000296 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 932919000297 putative substrate binding site [chemical binding]; other site 932919000298 nucleotide binding site [chemical binding]; other site 932919000299 nucleotide binding site [chemical binding]; other site 932919000300 homodimer interface [polypeptide binding]; other site 932919000301 agmatine deiminase; Provisional; Region: PRK13551 932919000302 agmatine deiminase; Region: agmatine_aguA; TIGR03380 932919000303 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932919000304 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932919000305 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932919000306 putative active site [active] 932919000307 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 932919000308 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 932919000309 arginine deiminase; Provisional; Region: PRK01388 932919000310 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 932919000311 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 932919000312 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 932919000313 dimer interface [polypeptide binding]; other site 932919000314 ssDNA binding site [nucleotide binding]; other site 932919000315 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932919000316 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 932919000317 Predicted membrane protein [Function unknown]; Region: COG3212 932919000318 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 932919000319 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 932919000320 putative accessory gene regulator protein; Provisional; Region: PRK01100 932919000321 Staphylococcal AgrD protein; Region: AgrD; cl05477 932919000322 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 932919000323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919000324 ATP binding site [chemical binding]; other site 932919000325 Mg2+ binding site [ion binding]; other site 932919000326 G-X-G motif; other site 932919000327 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 932919000328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919000329 active site 932919000330 phosphorylation site [posttranslational modification] 932919000331 intermolecular recognition site; other site 932919000332 LytTr DNA-binding domain; Region: LytTR; pfam04397 932919000333 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 932919000334 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 932919000335 DHH family; Region: DHH; pfam01368 932919000336 DHHA1 domain; Region: DHHA1; pfam02272 932919000337 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 932919000338 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 932919000339 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 932919000340 replicative DNA helicase; Provisional; Region: PRK05748 932919000341 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 932919000342 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 932919000343 Walker A motif; other site 932919000344 ATP binding site [chemical binding]; other site 932919000345 Walker B motif; other site 932919000346 DNA binding loops [nucleotide binding] 932919000347 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 932919000348 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 932919000349 GDP-binding site [chemical binding]; other site 932919000350 ACT binding site; other site 932919000351 IMP binding site; other site 932919000352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 932919000353 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 932919000354 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 932919000355 Predicted membrane protein [Function unknown]; Region: COG1511 932919000356 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 932919000357 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 932919000358 Uncharacterized small protein [Function unknown]; Region: COG5417 932919000359 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 932919000360 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 932919000361 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 932919000362 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 932919000363 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 932919000364 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 932919000365 LXG domain of WXG superfamily; Region: LXG; pfam04740 932919000366 Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013 932919000367 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 932919000368 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 932919000369 tetramer interface [polypeptide binding]; other site 932919000370 active site 932919000371 Mg2+/Mn2+ binding site [ion binding]; other site 932919000372 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 932919000373 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 932919000374 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 932919000375 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 932919000376 DNA binding site [nucleotide binding] 932919000377 active site 932919000378 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 932919000379 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 932919000380 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 932919000381 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 932919000382 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 932919000383 putative ligand binding site [chemical binding]; other site 932919000384 putative NAD binding site [chemical binding]; other site 932919000385 catalytic site [active] 932919000386 LXG domain of WXG superfamily; Region: LXG; pfam04740 932919000387 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 932919000388 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 932919000389 DNA binding residues [nucleotide binding] 932919000390 putative dimer interface [polypeptide binding]; other site 932919000391 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932919000392 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932919000393 active site 932919000394 catalytic tetrad [active] 932919000395 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919000396 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 932919000397 ATP synthase subunit C; Region: ATP-synt_C; cl00466 932919000398 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 932919000399 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 932919000400 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 932919000401 Walker A motif; other site 932919000402 ATP binding site [chemical binding]; other site 932919000403 Walker B motif; other site 932919000404 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 932919000405 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 932919000406 core domain interface [polypeptide binding]; other site 932919000407 delta subunit interface [polypeptide binding]; other site 932919000408 epsilon subunit interface [polypeptide binding]; other site 932919000409 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 932919000410 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 932919000411 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 932919000412 alpha subunit interaction interface [polypeptide binding]; other site 932919000413 Walker A motif; other site 932919000414 ATP binding site [chemical binding]; other site 932919000415 Walker B motif; other site 932919000416 inhibitor binding site; inhibition site 932919000417 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 932919000418 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823 932919000419 gamma subunit interface [polypeptide binding]; other site 932919000420 epsilon subunit interface [polypeptide binding]; other site 932919000421 LBP interface [polypeptide binding]; other site 932919000422 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 932919000423 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 932919000424 active pocket/dimerization site; other site 932919000425 active site 932919000426 phosphorylation site [posttranslational modification] 932919000427 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 932919000428 active site 932919000429 phosphorylation site [posttranslational modification] 932919000430 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 932919000431 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 932919000432 Domain of unknown function (DUF956); Region: DUF956; pfam06115 932919000433 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 932919000434 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932919000435 dimerization interface [polypeptide binding]; other site 932919000436 putative DNA binding site [nucleotide binding]; other site 932919000437 putative Zn2+ binding site [ion binding]; other site 932919000438 Uncharacterized conserved protein [Function unknown]; Region: COG1359 932919000439 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 932919000440 dimer interface [polypeptide binding]; other site 932919000441 FMN binding site [chemical binding]; other site 932919000442 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 932919000443 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 932919000444 active site 932919000445 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 932919000446 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 932919000447 Interdomain contacts; other site 932919000448 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 932919000449 aromatic chitin/cellulose binding site residues [chemical binding]; other site 932919000450 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 932919000451 LXG domain of WXG superfamily; Region: LXG; pfam04740 932919000452 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 932919000453 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932919000454 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932919000455 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 932919000456 Walker A/P-loop; other site 932919000457 ATP binding site [chemical binding]; other site 932919000458 Q-loop/lid; other site 932919000459 ABC transporter signature motif; other site 932919000460 Walker B; other site 932919000461 D-loop; other site 932919000462 H-loop/switch region; other site 932919000463 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932919000464 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932919000465 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 932919000466 Walker A/P-loop; other site 932919000467 ATP binding site [chemical binding]; other site 932919000468 Q-loop/lid; other site 932919000469 ABC transporter signature motif; other site 932919000470 Walker B; other site 932919000471 D-loop; other site 932919000472 H-loop/switch region; other site 932919000473 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 932919000474 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932919000475 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932919000476 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932919000477 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 932919000478 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 932919000479 substrate binding pocket [chemical binding]; other site 932919000480 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 932919000481 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932919000482 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919000483 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 932919000484 ligand binding site [chemical binding]; other site 932919000485 flexible hinge region; other site 932919000486 Domain of unknown function (DUF955); Region: DUF955; pfam06114 932919000487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919000488 non-specific DNA binding site [nucleotide binding]; other site 932919000489 salt bridge; other site 932919000490 sequence-specific DNA binding site [nucleotide binding]; other site 932919000491 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 932919000492 Predicted secreted protein [Function unknown]; Region: COG5437 932919000493 Phage-related protein [Function unknown]; Region: COG5412 932919000494 Phage tail protein; Region: Sipho_tail; pfam05709 932919000495 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 932919000496 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 932919000497 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 932919000498 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 932919000499 active site 932919000500 metal binding site [ion binding]; metal-binding site 932919000501 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 932919000502 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 932919000503 putative active site [active] 932919000504 putative metal binding site [ion binding]; other site 932919000505 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 932919000506 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932919000507 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 932919000508 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 932919000509 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 932919000510 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 932919000511 active site 932919000512 Uncharacterized conserved protein [Function unknown]; Region: COG3592 932919000513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919000514 Coenzyme A binding pocket [chemical binding]; other site 932919000515 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 932919000516 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 932919000517 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 932919000518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919000519 dimer interface [polypeptide binding]; other site 932919000520 conserved gate region; other site 932919000521 putative PBP binding loops; other site 932919000522 ABC-ATPase subunit interface; other site 932919000523 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 932919000524 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 932919000525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919000526 dimer interface [polypeptide binding]; other site 932919000527 conserved gate region; other site 932919000528 putative PBP binding loops; other site 932919000529 ABC-ATPase subunit interface; other site 932919000530 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 932919000531 LXG domain of WXG superfamily; Region: LXG; pfam04740 932919000532 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 932919000533 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 932919000534 peptide binding site [polypeptide binding]; other site 932919000535 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 932919000536 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 932919000537 metal binding site [ion binding]; metal-binding site 932919000538 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 932919000539 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 932919000540 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 932919000541 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932919000542 ABC-ATPase subunit interface; other site 932919000543 dimer interface [polypeptide binding]; other site 932919000544 putative PBP binding regions; other site 932919000545 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 932919000546 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919000547 ligand binding site [chemical binding]; other site 932919000548 flexible hinge region; other site 932919000549 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 932919000550 DEAD_2; Region: DEAD_2; pfam06733 932919000551 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 932919000552 sugar phosphate phosphatase; Provisional; Region: PRK10513 932919000553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919000554 active site 932919000555 motif I; other site 932919000556 motif II; other site 932919000557 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919000558 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 932919000559 Collagen binding domain; Region: Collagen_bind; pfam05737 932919000560 Cna protein B-type domain; Region: Cna_B; pfam05738 932919000561 Cna protein B-type domain; Region: Cna_B; pfam05738 932919000562 Cna protein B-type domain; Region: Cna_B; pfam05738 932919000563 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 932919000564 Collagen binding domain; Region: Collagen_bind; pfam05737 932919000565 Cna protein B-type domain; Region: Cna_B; pfam05738 932919000566 Cna protein B-type domain; Region: Cna_B; pfam05738 932919000567 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 932919000568 DNA polymerase III subunit delta'; Validated; Region: PRK08058 932919000569 DNA polymerase III subunit delta'; Validated; Region: PRK08485 932919000570 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 932919000571 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 932919000572 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 932919000573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919000574 S-adenosylmethionine binding site [chemical binding]; other site 932919000575 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 932919000576 GIY-YIG motif/motif A; other site 932919000577 putative active site [active] 932919000578 putative metal binding site [ion binding]; other site 932919000579 Predicted methyltransferases [General function prediction only]; Region: COG0313 932919000580 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 932919000581 putative SAM binding site [chemical binding]; other site 932919000582 putative homodimer interface [polypeptide binding]; other site 932919000583 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 932919000584 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 932919000585 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 932919000586 Uncharacterized conserved protein [Function unknown]; Region: COG5361 932919000587 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 932919000588 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 932919000589 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919000590 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 932919000591 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 932919000592 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 932919000593 active site 932919000594 HIGH motif; other site 932919000595 KMSKS motif; other site 932919000596 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 932919000597 tRNA binding surface [nucleotide binding]; other site 932919000598 anticodon binding site; other site 932919000599 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 932919000600 dimer interface [polypeptide binding]; other site 932919000601 putative tRNA-binding site [nucleotide binding]; other site 932919000602 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 932919000603 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932919000604 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932919000605 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 932919000606 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 932919000607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919000608 dimer interface [polypeptide binding]; other site 932919000609 conserved gate region; other site 932919000610 putative PBP binding loops; other site 932919000611 ABC-ATPase subunit interface; other site 932919000612 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932919000613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919000614 dimer interface [polypeptide binding]; other site 932919000615 conserved gate region; other site 932919000616 putative PBP binding loops; other site 932919000617 ABC-ATPase subunit interface; other site 932919000618 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 932919000619 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932919000620 alpha-glucosidase; Provisional; Region: PRK10426 932919000621 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 932919000622 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 932919000623 active site 932919000624 catalytic site [active] 932919000625 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 932919000626 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 932919000627 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 932919000628 trimer interface [polypeptide binding]; other site 932919000629 active site 932919000630 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 932919000631 catalytic site [active] 932919000632 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 932919000633 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 932919000634 Ca binding site [ion binding]; other site 932919000635 active site 932919000636 catalytic site [active] 932919000637 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 932919000638 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 932919000639 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 932919000640 active site 932919000641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 932919000642 Domain of unknown function (DUF348); Region: DUF348; pfam03990 932919000643 Domain of unknown function (DUF348); Region: DUF348; pfam03990 932919000644 G5 domain; Region: G5; pfam07501 932919000645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 932919000646 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 932919000647 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 932919000648 putative active site [active] 932919000649 putative metal binding site [ion binding]; other site 932919000650 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 932919000651 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 932919000652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919000653 S-adenosylmethionine binding site [chemical binding]; other site 932919000654 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 932919000655 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 932919000656 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 932919000657 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 932919000658 putative active site [active] 932919000659 YdjC motif; other site 932919000660 Mg binding site [ion binding]; other site 932919000661 putative homodimer interface [polypeptide binding]; other site 932919000662 pur operon repressor; Provisional; Region: PRK09213 932919000663 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 932919000664 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932919000665 active site 932919000666 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 932919000667 HlyD family secretion protein; Region: HlyD_3; pfam13437 932919000668 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932919000669 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932919000670 Walker A/P-loop; other site 932919000671 ATP binding site [chemical binding]; other site 932919000672 Q-loop/lid; other site 932919000673 ABC transporter signature motif; other site 932919000674 Walker B; other site 932919000675 D-loop; other site 932919000676 H-loop/switch region; other site 932919000677 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932919000678 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 932919000679 FtsX-like permease family; Region: FtsX; pfam02687 932919000680 regulatory protein SpoVG; Reviewed; Region: PRK13259 932919000681 regulatory protein SpoVG; Reviewed; Region: PRK13259 932919000682 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 932919000683 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 932919000684 Substrate binding site; other site 932919000685 Mg++ binding site; other site 932919000686 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 932919000687 active site 932919000688 substrate binding site [chemical binding]; other site 932919000689 CoA binding site [chemical binding]; other site 932919000690 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 932919000691 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 932919000692 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932919000693 active site 932919000694 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919000695 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932919000696 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 932919000697 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 932919000698 active site 932919000699 catalytic site [active] 932919000700 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 932919000701 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 932919000702 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 932919000703 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 932919000704 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 932919000705 active site 932919000706 Zn binding site [ion binding]; other site 932919000707 ActA Protein; Region: ActA; pfam05058 932919000708 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 932919000709 Zn binding site [ion binding]; other site 932919000710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 932919000711 hypothetical protein; Provisional; Region: PRK01119 932919000712 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 932919000713 A new structural DNA glycosylase; Region: AlkD_like; cd06561 932919000714 active site 932919000715 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 932919000716 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 932919000717 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932919000718 NAD binding site [chemical binding]; other site 932919000719 dimer interface [polypeptide binding]; other site 932919000720 substrate binding site [chemical binding]; other site 932919000721 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 932919000722 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 932919000723 5S rRNA interface [nucleotide binding]; other site 932919000724 CTC domain interface [polypeptide binding]; other site 932919000725 L16 interface [polypeptide binding]; other site 932919000726 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932919000727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919000728 Coenzyme A binding pocket [chemical binding]; other site 932919000729 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 932919000730 putative active site [active] 932919000731 catalytic residue [active] 932919000732 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 932919000733 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 932919000734 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932919000735 ATP binding site [chemical binding]; other site 932919000736 putative Mg++ binding site [ion binding]; other site 932919000737 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932919000738 nucleotide binding region [chemical binding]; other site 932919000739 ATP-binding site [chemical binding]; other site 932919000740 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 932919000741 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 932919000742 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 932919000743 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932919000744 RNA binding surface [nucleotide binding]; other site 932919000745 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 932919000746 Septum formation initiator; Region: DivIC; pfam04977 932919000747 hypothetical protein; Provisional; Region: PRK08582 932919000748 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 932919000749 RNA binding site [nucleotide binding]; other site 932919000750 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 932919000751 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 932919000752 Ligand Binding Site [chemical binding]; other site 932919000753 TilS substrate C-terminal domain; Region: TilS_C; smart00977 932919000754 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 932919000755 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932919000756 active site 932919000757 FtsH Extracellular; Region: FtsH_ext; pfam06480 932919000758 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 932919000759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919000760 Walker A motif; other site 932919000761 ATP binding site [chemical binding]; other site 932919000762 Walker B motif; other site 932919000763 arginine finger; other site 932919000764 Peptidase family M41; Region: Peptidase_M41; pfam01434 932919000765 pantothenate kinase; Reviewed; Region: PRK13318 932919000766 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 932919000767 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 932919000768 dimerization interface [polypeptide binding]; other site 932919000769 domain crossover interface; other site 932919000770 redox-dependent activation switch; other site 932919000771 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 932919000772 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 932919000773 dimer interface [polypeptide binding]; other site 932919000774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919000775 catalytic residue [active] 932919000776 dihydropteroate synthase; Region: DHPS; TIGR01496 932919000777 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 932919000778 substrate binding pocket [chemical binding]; other site 932919000779 dimer interface [polypeptide binding]; other site 932919000780 inhibitor binding site; inhibition site 932919000781 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 932919000782 homooctamer interface [polypeptide binding]; other site 932919000783 active site 932919000784 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 932919000785 catalytic center binding site [active] 932919000786 ATP binding site [chemical binding]; other site 932919000787 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 932919000788 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 932919000789 FMN binding site [chemical binding]; other site 932919000790 active site 932919000791 catalytic residues [active] 932919000792 substrate binding site [chemical binding]; other site 932919000793 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 932919000794 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 932919000795 dimer interface [polypeptide binding]; other site 932919000796 putative anticodon binding site; other site 932919000797 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 932919000798 motif 1; other site 932919000799 active site 932919000800 motif 2; other site 932919000801 motif 3; other site 932919000802 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 932919000803 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 932919000804 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 932919000805 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 932919000806 ADP binding site [chemical binding]; other site 932919000807 phosphagen binding site; other site 932919000808 substrate specificity loop; other site 932919000809 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 932919000810 Clp amino terminal domain; Region: Clp_N; pfam02861 932919000811 Clp amino terminal domain; Region: Clp_N; pfam02861 932919000812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919000813 Walker A motif; other site 932919000814 ATP binding site [chemical binding]; other site 932919000815 Walker B motif; other site 932919000816 arginine finger; other site 932919000817 UvrB/uvrC motif; Region: UVR; pfam02151 932919000818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919000819 Walker A motif; other site 932919000820 ATP binding site [chemical binding]; other site 932919000821 Walker B motif; other site 932919000822 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 932919000823 DNA repair protein RadA; Provisional; Region: PRK11823 932919000824 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 932919000825 Walker A motif/ATP binding site; other site 932919000826 ATP binding site [chemical binding]; other site 932919000827 Walker B motif; other site 932919000828 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 932919000829 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 932919000830 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 932919000831 putative active site [active] 932919000832 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 932919000833 substrate binding site; other site 932919000834 dimer interface; other site 932919000835 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 932919000836 homotrimer interaction site [polypeptide binding]; other site 932919000837 zinc binding site [ion binding]; other site 932919000838 CDP-binding sites; other site 932919000839 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 932919000840 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 932919000841 HIGH motif; other site 932919000842 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 932919000843 active site 932919000844 KMSKS motif; other site 932919000845 serine O-acetyltransferase; Region: cysE; TIGR01172 932919000846 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 932919000847 trimer interface [polypeptide binding]; other site 932919000848 active site 932919000849 substrate binding site [chemical binding]; other site 932919000850 CoA binding site [chemical binding]; other site 932919000851 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 932919000852 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 932919000853 active site 932919000854 HIGH motif; other site 932919000855 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 932919000856 KMSKS motif; other site 932919000857 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 932919000858 tRNA binding surface [nucleotide binding]; other site 932919000859 anticodon binding site; other site 932919000860 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 932919000861 active site 932919000862 metal binding site [ion binding]; metal-binding site 932919000863 dimerization interface [polypeptide binding]; other site 932919000864 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 932919000865 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 932919000866 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 932919000867 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 932919000868 RNA polymerase factor sigma-70; Validated; Region: PRK08295 932919000869 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932919000870 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 932919000871 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 932919000872 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 932919000873 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 932919000874 putative homodimer interface [polypeptide binding]; other site 932919000875 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 932919000876 heterodimer interface [polypeptide binding]; other site 932919000877 homodimer interface [polypeptide binding]; other site 932919000878 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 932919000879 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 932919000880 23S rRNA interface [nucleotide binding]; other site 932919000881 L7/L12 interface [polypeptide binding]; other site 932919000882 putative thiostrepton binding site; other site 932919000883 L25 interface [polypeptide binding]; other site 932919000884 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 932919000885 mRNA/rRNA interface [nucleotide binding]; other site 932919000886 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 932919000887 23S rRNA interface [nucleotide binding]; other site 932919000888 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 932919000889 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 932919000890 core dimer interface [polypeptide binding]; other site 932919000891 peripheral dimer interface [polypeptide binding]; other site 932919000892 L10 interface [polypeptide binding]; other site 932919000893 L11 interface [polypeptide binding]; other site 932919000894 putative EF-Tu interaction site [polypeptide binding]; other site 932919000895 putative EF-G interaction site [polypeptide binding]; other site 932919000896 Methyltransferase domain; Region: Methyltransf_31; pfam13847 932919000897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919000898 S-adenosylmethionine binding site [chemical binding]; other site 932919000899 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 932919000900 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932919000901 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932919000902 DNA binding site [nucleotide binding] 932919000903 domain linker motif; other site 932919000904 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 932919000905 putative dimerization interface [polypeptide binding]; other site 932919000906 putative ligand binding site [chemical binding]; other site 932919000907 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 932919000908 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932919000909 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 932919000910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919000911 dimer interface [polypeptide binding]; other site 932919000912 conserved gate region; other site 932919000913 putative PBP binding loops; other site 932919000914 ABC-ATPase subunit interface; other site 932919000915 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932919000916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919000917 dimer interface [polypeptide binding]; other site 932919000918 conserved gate region; other site 932919000919 putative PBP binding loops; other site 932919000920 ABC-ATPase subunit interface; other site 932919000921 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 932919000922 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 932919000923 Ca binding site [ion binding]; other site 932919000924 active site 932919000925 catalytic site [active] 932919000926 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 932919000927 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 932919000928 active site 932919000929 homodimer interface [polypeptide binding]; other site 932919000930 catalytic site [active] 932919000931 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 932919000932 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 932919000933 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 932919000934 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 932919000935 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 932919000936 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 932919000937 RPB10 interaction site [polypeptide binding]; other site 932919000938 RPB1 interaction site [polypeptide binding]; other site 932919000939 RPB11 interaction site [polypeptide binding]; other site 932919000940 RPB3 interaction site [polypeptide binding]; other site 932919000941 RPB12 interaction site [polypeptide binding]; other site 932919000942 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 932919000943 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 932919000944 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 932919000945 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 932919000946 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 932919000947 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 932919000948 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 932919000949 G-loop; other site 932919000950 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 932919000951 DNA binding site [nucleotide binding] 932919000952 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 932919000953 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 932919000954 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919000955 active site 932919000956 motif I; other site 932919000957 motif II; other site 932919000958 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932919000959 beta-galactosidase; Region: BGL; TIGR03356 932919000960 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 932919000961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 932919000962 Walker A/P-loop; other site 932919000963 ATP binding site [chemical binding]; other site 932919000964 Q-loop/lid; other site 932919000965 ABC transporter signature motif; other site 932919000966 Walker B; other site 932919000967 D-loop; other site 932919000968 H-loop/switch region; other site 932919000969 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 932919000970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 932919000971 Walker A/P-loop; other site 932919000972 ATP binding site [chemical binding]; other site 932919000973 Q-loop/lid; other site 932919000974 ABC transporter signature motif; other site 932919000975 Walker B; other site 932919000976 D-loop; other site 932919000977 H-loop/switch region; other site 932919000978 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932919000979 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932919000980 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 932919000981 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932919000982 LRR adjacent; Region: LRR_adjacent; pfam08191 932919000983 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919000984 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919000985 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932919000986 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932919000987 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919000988 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919000989 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919000990 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919000991 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919000992 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919000993 LRR adjacent; Region: LRR_adjacent; pfam08191 932919000994 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919000995 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919000996 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932919000997 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919000998 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919000999 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932919001000 Leucine-rich repeats; other site 932919001001 Substrate binding site [chemical binding]; other site 932919001002 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001003 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001004 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001005 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001006 LRR adjacent; Region: LRR_adjacent; pfam08191 932919001007 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919001008 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919001009 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 932919001010 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 932919001011 metal binding site [ion binding]; metal-binding site 932919001012 dimer interface [polypeptide binding]; other site 932919001013 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932919001014 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932919001015 putative Zn2+ binding site [ion binding]; other site 932919001016 putative DNA binding site [nucleotide binding]; other site 932919001017 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 932919001018 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932919001019 Zn binding site [ion binding]; other site 932919001020 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 932919001021 Zn binding site [ion binding]; other site 932919001022 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932919001023 catalytic core [active] 932919001024 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 932919001025 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 932919001026 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 932919001027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919001028 dimer interface [polypeptide binding]; other site 932919001029 conserved gate region; other site 932919001030 ABC-ATPase subunit interface; other site 932919001031 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932919001032 Substrate binding site [chemical binding]; other site 932919001033 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001034 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001035 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001036 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001037 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001038 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 932919001039 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932919001040 beta-galactosidase; Region: BGL; TIGR03356 932919001041 sugar phosphate phosphatase; Provisional; Region: PRK10513 932919001042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919001043 active site 932919001044 motif I; other site 932919001045 motif II; other site 932919001046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919001047 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919001048 Coenzyme A binding pocket [chemical binding]; other site 932919001049 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919001050 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 932919001051 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 932919001052 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 932919001053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919001054 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 932919001055 active site 932919001056 motif I; other site 932919001057 motif II; other site 932919001058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919001059 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932919001060 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932919001061 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932919001062 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 932919001063 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 932919001064 Walker A/P-loop; other site 932919001065 ATP binding site [chemical binding]; other site 932919001066 Q-loop/lid; other site 932919001067 ABC transporter signature motif; other site 932919001068 Walker B; other site 932919001069 D-loop; other site 932919001070 H-loop/switch region; other site 932919001071 TOBE domain; Region: TOBE; pfam03459 932919001072 ATP cone domain; Region: ATP-cone; pfam03477 932919001073 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 932919001074 Class III ribonucleotide reductase; Region: RNR_III; cd01675 932919001075 effector binding site; other site 932919001076 active site 932919001077 Zn binding site [ion binding]; other site 932919001078 glycine loop; other site 932919001079 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 932919001080 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 932919001081 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919001082 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932919001083 ligand binding site [chemical binding]; other site 932919001084 flexible hinge region; other site 932919001085 Predicted amidohydrolase [General function prediction only]; Region: COG0388 932919001086 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 932919001087 putative active site [active] 932919001088 catalytic triad [active] 932919001089 putative dimer interface [polypeptide binding]; other site 932919001090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919001091 dimer interface [polypeptide binding]; other site 932919001092 conserved gate region; other site 932919001093 ABC-ATPase subunit interface; other site 932919001094 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 932919001095 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 932919001096 Walker A/P-loop; other site 932919001097 ATP binding site [chemical binding]; other site 932919001098 Q-loop/lid; other site 932919001099 ABC transporter signature motif; other site 932919001100 Walker B; other site 932919001101 D-loop; other site 932919001102 H-loop/switch region; other site 932919001103 NIL domain; Region: NIL; pfam09383 932919001104 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 932919001105 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 932919001106 transaminase; Reviewed; Region: PRK08068 932919001107 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932919001108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919001109 homodimer interface [polypeptide binding]; other site 932919001110 catalytic residue [active] 932919001111 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932919001112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919001113 active site 932919001114 phosphorylation site [posttranslational modification] 932919001115 intermolecular recognition site; other site 932919001116 dimerization interface [polypeptide binding]; other site 932919001117 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932919001118 DNA binding site [nucleotide binding] 932919001119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 932919001120 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932919001121 dimerization interface [polypeptide binding]; other site 932919001122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932919001123 putative active site [active] 932919001124 heme pocket [chemical binding]; other site 932919001125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932919001126 dimer interface [polypeptide binding]; other site 932919001127 phosphorylation site [posttranslational modification] 932919001128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919001129 ATP binding site [chemical binding]; other site 932919001130 Mg2+ binding site [ion binding]; other site 932919001131 G-X-G motif; other site 932919001132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 932919001133 YycH protein; Region: YycH; pfam07435 932919001134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 932919001135 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 932919001136 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 932919001137 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 932919001138 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 932919001139 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 932919001140 protein binding site [polypeptide binding]; other site 932919001141 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 932919001142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932919001143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932919001144 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 932919001145 dimerization interface [polypeptide binding]; other site 932919001146 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 932919001147 dimer interface [polypeptide binding]; other site 932919001148 FMN binding site [chemical binding]; other site 932919001149 NADPH bind site [chemical binding]; other site 932919001150 DNA adenine methylase (dam); Region: dam; TIGR00571 932919001151 AIPR protein; Region: AIPR; pfam10592 932919001152 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932919001153 HTH domain; Region: HTH_11; pfam08279 932919001154 Mga helix-turn-helix domain; Region: Mga; pfam05043 932919001155 PRD domain; Region: PRD; pfam00874 932919001156 PRD domain; Region: PRD; pfam00874 932919001157 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932919001158 active site 932919001159 P-loop; other site 932919001160 phosphorylation site [posttranslational modification] 932919001161 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919001162 active site 932919001163 phosphorylation site [posttranslational modification] 932919001164 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932919001165 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932919001166 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932919001167 active site 932919001168 P-loop; other site 932919001169 phosphorylation site [posttranslational modification] 932919001170 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932919001171 beta-galactosidase; Region: BGL; TIGR03356 932919001172 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932919001173 methionine cluster; other site 932919001174 active site 932919001175 phosphorylation site [posttranslational modification] 932919001176 metal binding site [ion binding]; metal-binding site 932919001177 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 932919001178 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 932919001179 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 932919001180 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 932919001181 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932919001182 catalytic residue [active] 932919001183 Peptidase family M48; Region: Peptidase_M48; cl12018 932919001184 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 932919001185 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 932919001186 putative active site [active] 932919001187 YdjC motif; other site 932919001188 Mg binding site [ion binding]; other site 932919001189 putative homodimer interface [polypeptide binding]; other site 932919001190 Putative transcription activator [Transcription]; Region: TenA; COG0819 932919001191 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 932919001192 substrate binding site [chemical binding]; other site 932919001193 multimerization interface [polypeptide binding]; other site 932919001194 ATP binding site [chemical binding]; other site 932919001195 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 932919001196 dimer interface [polypeptide binding]; other site 932919001197 substrate binding site [chemical binding]; other site 932919001198 ATP binding site [chemical binding]; other site 932919001199 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 932919001200 thiamine phosphate binding site [chemical binding]; other site 932919001201 active site 932919001202 pyrophosphate binding site [ion binding]; other site 932919001203 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932919001204 beta-galactosidase; Region: BGL; TIGR03356 932919001205 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919001206 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 932919001207 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 932919001208 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 932919001209 putative catalytic site [active] 932919001210 putative metal binding site [ion binding]; other site 932919001211 putative phosphate binding site [ion binding]; other site 932919001212 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919001213 non-specific DNA binding site [nucleotide binding]; other site 932919001214 salt bridge; other site 932919001215 sequence-specific DNA binding site [nucleotide binding]; other site 932919001216 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 932919001217 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919001218 non-specific DNA binding site [nucleotide binding]; other site 932919001219 salt bridge; other site 932919001220 sequence-specific DNA binding site [nucleotide binding]; other site 932919001221 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 932919001222 Leucine rich repeat; Region: LRR_8; pfam13855 932919001223 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001224 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001225 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001226 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001227 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001228 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001229 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001230 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001231 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001232 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001233 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001234 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001235 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001236 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001237 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001238 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001239 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919001240 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001241 Leucine rich repeat; Region: LRR_8; pfam13855 932919001242 LRR adjacent; Region: LRR_adjacent; pfam08191 932919001243 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919001244 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932919001245 Leucine-rich repeats; other site 932919001246 Substrate binding site [chemical binding]; other site 932919001247 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001248 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001249 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001250 Leucine rich repeat; Region: LRR_8; pfam13855 932919001251 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932919001252 Leucine-rich repeats; other site 932919001253 Leucine rich repeat; Region: LRR_8; pfam13855 932919001254 Substrate binding site [chemical binding]; other site 932919001255 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001256 Leucine rich repeat; Region: LRR_8; pfam13855 932919001257 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001258 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001259 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001260 LRR adjacent; Region: LRR_adjacent; pfam08191 932919001261 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001262 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001263 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001264 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 932919001265 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 932919001266 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 932919001267 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 932919001268 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 932919001269 TPP-binding site [chemical binding]; other site 932919001270 dimer interface [polypeptide binding]; other site 932919001271 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 932919001272 PYR/PP interface [polypeptide binding]; other site 932919001273 dimer interface [polypeptide binding]; other site 932919001274 TPP binding site [chemical binding]; other site 932919001275 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932919001276 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 932919001277 active site 932919001278 intersubunit interactions; other site 932919001279 catalytic residue [active] 932919001280 short chain dehydrogenase; Provisional; Region: PRK06841 932919001281 classical (c) SDRs; Region: SDR_c; cd05233 932919001282 NAD(P) binding site [chemical binding]; other site 932919001283 active site 932919001284 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 932919001285 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 932919001286 substrate binding site [chemical binding]; other site 932919001287 dimer interface [polypeptide binding]; other site 932919001288 catalytic triad [active] 932919001289 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 932919001290 DAK2 domain; Region: Dak2; cl03685 932919001291 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 932919001292 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 932919001293 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 932919001294 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932919001295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932919001296 putative DNA binding site [nucleotide binding]; other site 932919001297 putative Zn2+ binding site [ion binding]; other site 932919001298 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932919001299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919001300 Coenzyme A binding pocket [chemical binding]; other site 932919001301 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932919001302 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 932919001303 LRR adjacent; Region: LRR_adjacent; pfam08191 932919001304 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919001305 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919001306 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 932919001307 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 932919001308 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 932919001309 acyl-activating enzyme (AAE) consensus motif; other site 932919001310 acyl-activating enzyme (AAE) consensus motif; other site 932919001311 AMP binding site [chemical binding]; other site 932919001312 active site 932919001313 CoA binding site [chemical binding]; other site 932919001314 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 932919001315 L-aspartate oxidase; Provisional; Region: PRK06175 932919001316 putative oxidoreductase; Provisional; Region: PRK10206 932919001317 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932919001318 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932919001319 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919001320 active site 932919001321 phosphorylation site [posttranslational modification] 932919001322 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 932919001323 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932919001324 active site 932919001325 P-loop; other site 932919001326 phosphorylation site [posttranslational modification] 932919001327 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 932919001328 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 932919001329 intersubunit interface [polypeptide binding]; other site 932919001330 active site 932919001331 zinc binding site [ion binding]; other site 932919001332 Na+ binding site [ion binding]; other site 932919001333 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932919001334 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 932919001335 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932919001336 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 932919001337 conserved cys residue [active] 932919001338 Predicted transcriptional regulator [Transcription]; Region: COG2378 932919001339 HTH domain; Region: HTH_11; pfam08279 932919001340 WYL domain; Region: WYL; pfam13280 932919001341 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 932919001342 nudix motif; other site 932919001343 hypothetical protein; Provisional; Region: PRK12378 932919001344 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 932919001345 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 932919001346 PhnA protein; Region: PhnA; pfam03831 932919001347 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932919001348 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919001349 DNA-binding site [nucleotide binding]; DNA binding site 932919001350 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 932919001351 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932919001352 beta-galactosidase; Region: BGL; TIGR03356 932919001353 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932919001354 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 932919001355 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932919001356 active site 932919001357 P-loop; other site 932919001358 phosphorylation site [posttranslational modification] 932919001359 Predicted transcriptional regulator [Transcription]; Region: COG2378 932919001360 HTH domain; Region: HTH_11; pfam08279 932919001361 WYL domain; Region: WYL; pfam13280 932919001362 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 932919001363 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932919001364 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 932919001365 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932919001366 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 932919001367 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 932919001368 tetrameric interface [polypeptide binding]; other site 932919001369 NAD binding site [chemical binding]; other site 932919001370 catalytic residues [active] 932919001371 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 932919001372 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932919001373 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 932919001374 substrate binding site [chemical binding]; other site 932919001375 ATP binding site [chemical binding]; other site 932919001376 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 932919001377 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 932919001378 PYR/PP interface [polypeptide binding]; other site 932919001379 dimer interface [polypeptide binding]; other site 932919001380 TPP binding site [chemical binding]; other site 932919001381 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 932919001382 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 932919001383 TPP-binding site; other site 932919001384 Uncharacterized conserved protein [Function unknown]; Region: COG5646 932919001385 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 932919001386 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 932919001387 ligand binding site [chemical binding]; other site 932919001388 active site 932919001389 UGI interface [polypeptide binding]; other site 932919001390 catalytic site [active] 932919001391 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 932919001392 hypothetical protein; Provisional; Region: PRK13665 932919001393 Bacterial SH3 domain; Region: SH3_3; cl17532 932919001394 NlpC/P60 family; Region: NLPC_P60; pfam00877 932919001395 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932919001396 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919001397 Coenzyme A binding pocket [chemical binding]; other site 932919001398 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 932919001399 pyrroline-5-carboxylate reductase; Region: PLN02688 932919001400 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919001401 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919001402 Transcriptional regulators [Transcription]; Region: GntR; COG1802 932919001403 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919001404 DNA-binding site [nucleotide binding]; DNA binding site 932919001405 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 932919001406 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932919001407 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932919001408 Walker A/P-loop; other site 932919001409 ATP binding site [chemical binding]; other site 932919001410 Q-loop/lid; other site 932919001411 ABC transporter signature motif; other site 932919001412 Walker B; other site 932919001413 D-loop; other site 932919001414 H-loop/switch region; other site 932919001415 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932919001416 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 932919001417 FtsX-like permease family; Region: FtsX; pfam02687 932919001418 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 932919001419 putative hydrophobic ligand binding site [chemical binding]; other site 932919001420 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919001421 active site 932919001422 phosphorylation site [posttranslational modification] 932919001423 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932919001424 active site 932919001425 P-loop; other site 932919001426 phosphorylation site [posttranslational modification] 932919001427 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 932919001428 alpha-mannosidase; Provisional; Region: PRK09819 932919001429 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 932919001430 active site 932919001431 metal binding site [ion binding]; metal-binding site 932919001432 catalytic site [active] 932919001433 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 932919001434 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932919001435 HTH domain; Region: HTH_11; pfam08279 932919001436 Mga helix-turn-helix domain; Region: Mga; pfam05043 932919001437 PRD domain; Region: PRD; pfam00874 932919001438 PRD domain; Region: PRD; pfam00874 932919001439 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932919001440 active site 932919001441 P-loop; other site 932919001442 phosphorylation site [posttranslational modification] 932919001443 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919001444 active site 932919001445 phosphorylation site [posttranslational modification] 932919001446 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 932919001447 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 932919001448 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932919001449 putative metal binding site [ion binding]; other site 932919001450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 932919001451 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 932919001452 trimer interface [polypeptide binding]; other site 932919001453 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932919001454 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001455 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932919001456 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001457 Leucine-rich repeats; other site 932919001458 Substrate binding site [chemical binding]; other site 932919001459 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001460 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001461 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001462 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001463 LRR adjacent; Region: LRR_adjacent; pfam08191 932919001464 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919001465 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919001466 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919001467 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919001468 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919001469 phosphoenolpyruvate synthase; Validated; Region: PRK06241 932919001470 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 932919001471 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 932919001472 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 932919001473 ZIP Zinc transporter; Region: Zip; pfam02535 932919001474 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 932919001475 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 932919001476 NodB motif; other site 932919001477 active site 932919001478 catalytic site [active] 932919001479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919001480 non-specific DNA binding site [nucleotide binding]; other site 932919001481 salt bridge; other site 932919001482 sequence-specific DNA binding site [nucleotide binding]; other site 932919001483 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 932919001484 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932919001485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919001486 active site 932919001487 motif I; other site 932919001488 motif II; other site 932919001489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919001490 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 932919001491 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932919001492 HTH domain; Region: HTH_11; pfam08279 932919001493 PRD domain; Region: PRD; pfam00874 932919001494 PRD domain; Region: PRD; pfam00874 932919001495 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932919001496 active site 932919001497 P-loop; other site 932919001498 phosphorylation site [posttranslational modification] 932919001499 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919001500 active site 932919001501 phosphorylation site [posttranslational modification] 932919001502 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919001503 active site 932919001504 phosphorylation site [posttranslational modification] 932919001505 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932919001506 active site 932919001507 P-loop; other site 932919001508 phosphorylation site [posttranslational modification] 932919001509 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 932919001510 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 932919001511 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 932919001512 active site 932919001513 metal binding site [ion binding]; metal-binding site 932919001514 catalytic site [active] 932919001515 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 932919001516 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932919001517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932919001518 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 932919001519 dimerization interface [polypeptide binding]; other site 932919001520 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 932919001521 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 932919001522 active site 932919001523 substrate binding site [chemical binding]; other site 932919001524 trimer interface [polypeptide binding]; other site 932919001525 CoA binding site [chemical binding]; other site 932919001526 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 932919001527 classical (c) SDRs; Region: SDR_c; cd05233 932919001528 NAD(P) binding site [chemical binding]; other site 932919001529 active site 932919001530 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932919001531 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001532 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932919001533 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001534 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001535 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001536 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001537 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001538 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001539 LRR adjacent; Region: LRR_adjacent; pfam08191 932919001540 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919001541 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919001542 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919001543 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 932919001544 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932919001545 Leucine rich repeat; Region: LRR_8; pfam13855 932919001546 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932919001547 Leucine rich repeat; Region: LRR_8; pfam13855 932919001548 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001549 LRR adjacent; Region: LRR_adjacent; pfam08191 932919001550 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919001551 SH3-like domain; Region: SH3_8; pfam13457 932919001552 Predicted transcriptional regulator [Transcription]; Region: COG1959 932919001553 Transcriptional regulator; Region: Rrf2; pfam02082 932919001554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932919001555 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 932919001556 NAD(P) binding site [chemical binding]; other site 932919001557 active site 932919001558 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 932919001559 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 932919001560 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 932919001561 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 932919001562 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 932919001563 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 932919001564 Transcriptional regulator [Transcription]; Region: LytR; COG1316 932919001565 Predicted membrane protein [Function unknown]; Region: COG1511 932919001566 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 932919001567 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 932919001568 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 932919001569 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 932919001570 Mga helix-turn-helix domain; Region: Mga; pfam05043 932919001571 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 932919001572 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 932919001573 active site 932919001574 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 932919001575 L-tyrosine decarboxylase; Provisional; Region: PRK13520 932919001576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919001577 catalytic residue [active] 932919001578 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 932919001579 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 932919001580 Predicted membrane protein [Function unknown]; Region: COG3619 932919001581 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 932919001582 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 932919001583 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 932919001584 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 932919001585 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 932919001586 Protein of unknown function DUF58; Region: DUF58; pfam01882 932919001587 MoxR-like ATPases [General function prediction only]; Region: COG0714 932919001588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919001589 Walker A motif; other site 932919001590 ATP binding site [chemical binding]; other site 932919001591 Walker B motif; other site 932919001592 arginine finger; other site 932919001593 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 932919001594 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 932919001595 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 932919001596 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 932919001597 Na binding site [ion binding]; other site 932919001598 Uncharacterized conserved protein [Function unknown]; Region: COG3535 932919001599 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 932919001600 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932919001601 nucleotide binding site [chemical binding]; other site 932919001602 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 932919001603 Mga helix-turn-helix domain; Region: Mga; pfam05043 932919001604 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 932919001605 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001606 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001607 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001608 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 932919001609 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001610 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001611 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001612 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001613 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919001614 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 932919001615 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001616 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001617 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001618 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 932919001619 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001620 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001621 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001622 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001623 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001624 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919001625 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 932919001626 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001627 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001628 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001629 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919001630 Leucine rich repeat; Region: LRR_8; pfam13855 932919001631 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919001632 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932919001633 Zn2+ binding site [ion binding]; other site 932919001634 Mg2+ binding site [ion binding]; other site 932919001635 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 932919001636 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 932919001637 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 932919001638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932919001639 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 932919001640 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 932919001641 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932919001642 FeS/SAM binding site; other site 932919001643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 932919001644 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 932919001645 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 932919001646 putative active site [active] 932919001647 putative NTP binding site [chemical binding]; other site 932919001648 putative nucleic acid binding site [nucleotide binding]; other site 932919001649 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 932919001650 putative FMN binding site [chemical binding]; other site 932919001651 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 932919001652 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 932919001653 nudix motif; other site 932919001654 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932919001655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932919001656 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 932919001657 putative dimerization interface [polypeptide binding]; other site 932919001658 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 932919001659 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 932919001660 active site 932919001661 FMN binding site [chemical binding]; other site 932919001662 substrate binding site [chemical binding]; other site 932919001663 putative catalytic residue [active] 932919001664 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 932919001665 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932919001666 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932919001667 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 932919001668 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 932919001669 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 932919001670 shikimate binding site; other site 932919001671 NAD(P) binding site [chemical binding]; other site 932919001672 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 932919001673 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 932919001674 active site 932919001675 catalytic residue [active] 932919001676 dimer interface [polypeptide binding]; other site 932919001677 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932919001678 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932919001679 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 932919001680 dimerization interface [polypeptide binding]; other site 932919001681 substrate binding pocket [chemical binding]; other site 932919001682 Predicted acyl esterases [General function prediction only]; Region: COG2936 932919001683 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 932919001684 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 932919001685 active site 932919001686 catalytic triad [active] 932919001687 oxyanion hole [active] 932919001688 EamA-like transporter family; Region: EamA; pfam00892 932919001689 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 932919001690 EamA-like transporter family; Region: EamA; pfam00892 932919001691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 932919001692 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932919001693 active site 932919001694 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 932919001695 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 932919001696 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 932919001697 substrate binding site [chemical binding]; other site 932919001698 hexamer interface [polypeptide binding]; other site 932919001699 metal binding site [ion binding]; metal-binding site 932919001700 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 932919001701 catalytic residue [active] 932919001702 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932919001703 PRD domain; Region: PRD; pfam00874 932919001704 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932919001705 active site 932919001706 P-loop; other site 932919001707 phosphorylation site [posttranslational modification] 932919001708 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919001709 active site 932919001710 phosphorylation site [posttranslational modification] 932919001711 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 932919001712 putative active site [active] 932919001713 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919001714 active site 932919001715 phosphorylation site [posttranslational modification] 932919001716 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 932919001717 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 932919001718 substrate binding site [chemical binding]; other site 932919001719 hexamer interface [polypeptide binding]; other site 932919001720 metal binding site [ion binding]; metal-binding site 932919001721 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 932919001722 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 932919001723 putative NAD(P) binding site [chemical binding]; other site 932919001724 catalytic Zn binding site [ion binding]; other site 932919001725 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 932919001726 active site 932919001727 P-loop; other site 932919001728 phosphorylation site [posttranslational modification] 932919001729 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 932919001730 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 932919001731 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 932919001732 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 932919001733 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932919001734 active site 932919001735 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 932919001736 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 932919001737 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 932919001738 catalytic triad [active] 932919001739 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 932919001740 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932919001741 MarR family; Region: MarR_2; pfam12802 932919001742 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001743 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919001744 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 932919001745 Ligand Binding Site [chemical binding]; other site 932919001746 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 932919001747 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 932919001748 putative active site [active] 932919001749 putative metal binding site [ion binding]; other site 932919001750 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932919001751 catalytic core [active] 932919001752 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932919001753 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 932919001754 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754 932919001755 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 932919001756 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 932919001757 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 932919001758 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 932919001759 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 932919001760 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 932919001761 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 932919001762 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 932919001763 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 932919001764 Predicted membrane protein [Function unknown]; Region: COG3759 932919001765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919001766 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932919001767 putative substrate translocation pore; other site 932919001768 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 932919001769 non-specific DNA interactions [nucleotide binding]; other site 932919001770 DNA binding site [nucleotide binding] 932919001771 sequence specific DNA binding site [nucleotide binding]; other site 932919001772 putative cAMP binding site [chemical binding]; other site 932919001773 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932919001774 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 932919001775 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 932919001776 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 932919001777 NAD binding site [chemical binding]; other site 932919001778 sugar binding site [chemical binding]; other site 932919001779 divalent metal binding site [ion binding]; other site 932919001780 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932919001781 dimer interface [polypeptide binding]; other site 932919001782 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932919001783 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932919001784 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932919001785 putative active site [active] 932919001786 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 932919001787 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 932919001788 Sulfate transporter family; Region: Sulfate_transp; pfam00916 932919001789 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 932919001790 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 932919001791 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 932919001792 DNA binding residues [nucleotide binding] 932919001793 dimer interface [polypeptide binding]; other site 932919001794 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 932919001795 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 932919001796 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 932919001797 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 932919001798 DXD motif; other site 932919001799 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 932919001800 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 932919001801 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932919001802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919001803 S-adenosylmethionine binding site [chemical binding]; other site 932919001804 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 932919001805 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 932919001806 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932919001807 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932919001808 DNA binding site [nucleotide binding] 932919001809 domain linker motif; other site 932919001810 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 932919001811 putative dimerization interface [polypeptide binding]; other site 932919001812 putative ligand binding site [chemical binding]; other site 932919001813 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 932919001814 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 932919001815 NAD binding site [chemical binding]; other site 932919001816 sugar binding site [chemical binding]; other site 932919001817 divalent metal binding site [ion binding]; other site 932919001818 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932919001819 dimer interface [polypeptide binding]; other site 932919001820 allantoate amidohydrolase; Reviewed; Region: PRK09290 932919001821 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 932919001822 active site 932919001823 metal binding site [ion binding]; metal-binding site 932919001824 dimer interface [polypeptide binding]; other site 932919001825 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 932919001826 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 932919001827 metal binding site [ion binding]; metal-binding site 932919001828 putative dimer interface [polypeptide binding]; other site 932919001829 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 932919001830 Beta-lactamase; Region: Beta-lactamase; pfam00144 932919001831 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 932919001832 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 932919001833 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 932919001834 intersubunit interface [polypeptide binding]; other site 932919001835 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 932919001836 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 932919001837 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 932919001838 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 932919001839 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 932919001840 Glucitol operon activator protein (GutM); Region: GutM; cl01890 932919001841 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 932919001842 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932919001843 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 932919001844 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 932919001845 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 932919001846 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919001847 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 932919001848 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001849 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001850 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919001851 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919001852 WxL domain surface cell wall-binding; Region: WxL; pfam13731 932919001853 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 932919001854 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 932919001855 FOG: CBS domain [General function prediction only]; Region: COG0517 932919001856 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 932919001857 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 932919001858 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 932919001859 dimer interface [polypeptide binding]; other site 932919001860 active site 932919001861 metal binding site [ion binding]; metal-binding site 932919001862 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 932919001863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919001864 putative substrate translocation pore; other site 932919001865 POT family; Region: PTR2; pfam00854 932919001866 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932919001867 catalytic core [active] 932919001868 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932919001869 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932919001870 catalytic core [active] 932919001871 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932919001872 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 932919001873 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 932919001874 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 932919001875 Cl binding site [ion binding]; other site 932919001876 oligomer interface [polypeptide binding]; other site 932919001877 glutamate dehydrogenase; Provisional; Region: PRK09414 932919001878 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 932919001879 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 932919001880 NAD(P) binding site [chemical binding]; other site 932919001881 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 932919001882 metal binding site [ion binding]; metal-binding site 932919001883 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 932919001884 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 932919001885 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 932919001886 substrate binding site [chemical binding]; other site 932919001887 glutamase interaction surface [polypeptide binding]; other site 932919001888 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 932919001889 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 932919001890 catalytic residues [active] 932919001891 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 932919001892 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 932919001893 putative active site [active] 932919001894 oxyanion strand; other site 932919001895 catalytic triad [active] 932919001896 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 932919001897 putative active site pocket [active] 932919001898 4-fold oligomerization interface [polypeptide binding]; other site 932919001899 metal binding residues [ion binding]; metal-binding site 932919001900 3-fold/trimer interface [polypeptide binding]; other site 932919001901 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 932919001902 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 932919001903 NAD binding site [chemical binding]; other site 932919001904 dimerization interface [polypeptide binding]; other site 932919001905 product binding site; other site 932919001906 substrate binding site [chemical binding]; other site 932919001907 zinc binding site [ion binding]; other site 932919001908 catalytic residues [active] 932919001909 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 932919001910 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 932919001911 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 932919001912 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 932919001913 dimer interface [polypeptide binding]; other site 932919001914 motif 1; other site 932919001915 active site 932919001916 motif 2; other site 932919001917 motif 3; other site 932919001918 histidinol-phosphatase; Reviewed; Region: PRK08123 932919001919 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 932919001920 active site 932919001921 dimer interface [polypeptide binding]; other site 932919001922 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 932919001923 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 932919001924 DNA binding site [nucleotide binding] 932919001925 active site 932919001926 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 932919001927 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 932919001928 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932919001929 beta-galactosidase; Region: BGL; TIGR03356 932919001930 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932919001931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919001932 DNA-binding site [nucleotide binding]; DNA binding site 932919001933 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 932919001934 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001935 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919001936 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 932919001937 Uncharacterized conserved protein [Function unknown]; Region: COG2966 932919001938 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 932919001939 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 932919001940 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 932919001941 Predicted esterase [General function prediction only]; Region: COG0400 932919001942 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 932919001943 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 932919001944 putative RNA binding site [nucleotide binding]; other site 932919001945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919001946 S-adenosylmethionine binding site [chemical binding]; other site 932919001947 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 932919001948 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932919001949 Bacterial SH3 domain; Region: SH3_3; pfam08239 932919001950 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932919001951 NlpC/P60 family; Region: NLPC_P60; pfam00877 932919001952 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 932919001953 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 932919001954 ATP binding site [chemical binding]; other site 932919001955 putative Mg++ binding site [ion binding]; other site 932919001956 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 932919001957 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 932919001958 nucleotide binding region [chemical binding]; other site 932919001959 ATP-binding site [chemical binding]; other site 932919001960 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 932919001961 Domain of unknown function DUF20; Region: UPF0118; pfam01594 932919001962 WxL domain surface cell wall-binding; Region: WxL; pfam13731 932919001963 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 932919001964 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 932919001965 UreD urease accessory protein; Region: UreD; cl00530 932919001966 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 932919001967 DNA photolyase; Region: DNA_photolyase; pfam00875 932919001968 Predicted membrane protein [Function unknown]; Region: COG4852 932919001969 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 932919001970 DAK2 domain; Region: Dak2; pfam02734 932919001971 EDD domain protein, DegV family; Region: DegV; TIGR00762 932919001972 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 932919001973 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 932919001974 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 932919001975 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 932919001976 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 932919001977 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 932919001978 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 932919001979 homodimer interface [polypeptide binding]; other site 932919001980 substrate-cofactor binding pocket; other site 932919001981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919001982 catalytic residue [active] 932919001983 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 932919001984 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919001985 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 932919001986 ligand binding site [chemical binding]; other site 932919001987 flexible hinge region; other site 932919001988 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 932919001989 BioY family; Region: BioY; pfam02632 932919001990 Predicted transcriptional regulators [Transcription]; Region: COG1695 932919001991 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 932919001992 Predicted membrane protein [Function unknown]; Region: COG4709 932919001993 Uncharacterized conserved protein [Function unknown]; Region: COG3595 932919001994 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 932919001995 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 932919001996 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 932919001997 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 932919001998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919001999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 932919002000 Coenzyme A binding pocket [chemical binding]; other site 932919002001 Tic20-like protein; Region: Tic20; pfam09685 932919002002 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 932919002003 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 932919002004 Transcriptional regulators [Transcription]; Region: MarR; COG1846 932919002005 MarR family; Region: MarR_2; pfam12802 932919002006 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932919002007 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932919002008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919002009 Walker A/P-loop; other site 932919002010 ATP binding site [chemical binding]; other site 932919002011 Q-loop/lid; other site 932919002012 ABC transporter signature motif; other site 932919002013 Walker B; other site 932919002014 D-loop; other site 932919002015 H-loop/switch region; other site 932919002016 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932919002017 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932919002018 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 932919002019 Walker A/P-loop; other site 932919002020 ATP binding site [chemical binding]; other site 932919002021 Q-loop/lid; other site 932919002022 ABC transporter signature motif; other site 932919002023 Walker B; other site 932919002024 D-loop; other site 932919002025 H-loop/switch region; other site 932919002026 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 932919002027 active site residue [active] 932919002028 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919002029 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 932919002030 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 932919002031 Transcriptional regulators [Transcription]; Region: MarR; COG1846 932919002032 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932919002033 putative DNA binding site [nucleotide binding]; other site 932919002034 putative Zn2+ binding site [ion binding]; other site 932919002035 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 932919002036 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 932919002037 putative NAD(P) binding site [chemical binding]; other site 932919002038 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 932919002039 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932919002040 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 932919002041 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 932919002042 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 932919002043 putative active site [active] 932919002044 catalytic site [active] 932919002045 putative metal binding site [ion binding]; other site 932919002046 Catalytic domain of Protein Kinases; Region: PKc; cd00180 932919002047 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 932919002048 active site 932919002049 ATP binding site [chemical binding]; other site 932919002050 substrate binding site [chemical binding]; other site 932919002051 activation loop (A-loop); other site 932919002052 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 932919002053 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 932919002054 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 932919002055 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932919002056 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919002057 Coenzyme A binding pocket [chemical binding]; other site 932919002058 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 932919002059 active site 932919002060 catalytic triad [active] 932919002061 oxyanion hole [active] 932919002062 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 932919002063 domain interaction interfaces [polypeptide binding]; other site 932919002064 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 932919002065 domain interaction interfaces [polypeptide binding]; other site 932919002066 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 932919002067 domain interaction interfaces [polypeptide binding]; other site 932919002068 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 932919002069 domain interaction interfaces [polypeptide binding]; other site 932919002070 Isochorismatase family; Region: Isochorismatase; pfam00857 932919002071 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 932919002072 catalytic triad [active] 932919002073 conserved cis-peptide bond; other site 932919002074 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932919002075 PRD domain; Region: PRD; pfam00874 932919002076 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932919002077 active site 932919002078 P-loop; other site 932919002079 phosphorylation site [posttranslational modification] 932919002080 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919002081 active site 932919002082 phosphorylation site [posttranslational modification] 932919002083 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919002084 active site 932919002085 phosphorylation site [posttranslational modification] 932919002086 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 932919002087 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932919002088 active site 932919002089 P-loop; other site 932919002090 phosphorylation site [posttranslational modification] 932919002091 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 932919002092 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 932919002093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919002094 motif II; other site 932919002095 Predicted transcriptional regulator [Transcription]; Region: COG1959 932919002096 Transcriptional regulator; Region: Rrf2; pfam02082 932919002097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919002098 S-adenosylmethionine binding site [chemical binding]; other site 932919002099 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 932919002100 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 932919002101 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 932919002102 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932919002103 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932919002104 active site 932919002105 catalytic tetrad [active] 932919002106 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 932919002107 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932919002108 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919002109 motif II; other site 932919002110 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 932919002111 catalytic residue [active] 932919002112 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 932919002113 Sulfatase; Region: Sulfatase; pfam00884 932919002114 amino acid transporter; Region: 2A0306; TIGR00909 932919002115 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 932919002116 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 932919002117 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 932919002118 putative metal binding site [ion binding]; other site 932919002119 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 932919002120 active site 932919002121 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 932919002122 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 932919002123 Cl binding site [ion binding]; other site 932919002124 oligomer interface [polypeptide binding]; other site 932919002125 Transcriptional regulators [Transcription]; Region: GntR; COG1802 932919002126 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919002127 DNA-binding site [nucleotide binding]; DNA binding site 932919002128 Predicted membrane protein [Function unknown]; Region: COG1511 932919002129 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 932919002130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919002131 Transcriptional regulators [Transcription]; Region: GntR; COG1802 932919002132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919002133 DNA-binding site [nucleotide binding]; DNA binding site 932919002134 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932919002135 Predicted integral membrane protein [Function unknown]; Region: COG5523 932919002136 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 932919002137 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 932919002138 active site 932919002139 metal binding site [ion binding]; metal-binding site 932919002140 Predicted membrane protein [Function unknown]; Region: COG2322 932919002141 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 932919002142 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 932919002143 minor groove reading motif; other site 932919002144 helix-hairpin-helix signature motif; other site 932919002145 substrate binding pocket [chemical binding]; other site 932919002146 active site 932919002147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919002148 non-specific DNA binding site [nucleotide binding]; other site 932919002149 salt bridge; other site 932919002150 sequence-specific DNA binding site [nucleotide binding]; other site 932919002151 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 932919002152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 932919002153 Transposase; Region: HTH_Tnp_1; cl17663 932919002154 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919002155 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919002156 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919002157 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 932919002158 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 932919002159 dimer interface [polypeptide binding]; other site 932919002160 substrate binding site [chemical binding]; other site 932919002161 ATP binding site [chemical binding]; other site 932919002162 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932919002163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919002164 active site 932919002165 motif I; other site 932919002166 motif II; other site 932919002167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919002168 maltose O-acetyltransferase; Provisional; Region: PRK10092 932919002169 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 932919002170 active site 932919002171 substrate binding site [chemical binding]; other site 932919002172 trimer interface [polypeptide binding]; other site 932919002173 CoA binding site [chemical binding]; other site 932919002174 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 932919002175 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 932919002176 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 932919002177 Walker A/P-loop; other site 932919002178 ATP binding site [chemical binding]; other site 932919002179 Q-loop/lid; other site 932919002180 ABC transporter signature motif; other site 932919002181 Walker B; other site 932919002182 D-loop; other site 932919002183 H-loop/switch region; other site 932919002184 inner membrane transport permease; Provisional; Region: PRK15066 932919002185 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 932919002186 oxidoreductase; Provisional; Region: PRK07985 932919002187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932919002188 NAD(P) binding site [chemical binding]; other site 932919002189 active site 932919002190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 932919002191 Predicted membrane protein [Function unknown]; Region: COG3152 932919002192 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 932919002193 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 932919002194 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 932919002195 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 932919002196 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 932919002197 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 932919002198 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 932919002199 FHIPEP family; Region: FHIPEP; pfam00771 932919002200 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 932919002201 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 932919002202 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 932919002203 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 932919002204 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 932919002205 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 932919002206 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 932919002207 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 932919002208 flagellar motor protein MotA; Validated; Region: PRK08124 932919002209 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 932919002210 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 932919002211 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 932919002212 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 932919002213 ligand binding site [chemical binding]; other site 932919002214 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 932919002215 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 932919002216 putative metal binding site; other site 932919002217 TPR repeat; Region: TPR_11; pfam13414 932919002218 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932919002219 binding surface 932919002220 TPR motif; other site 932919002221 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 932919002222 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 932919002223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919002224 active site 932919002225 phosphorylation site [posttranslational modification] 932919002226 intermolecular recognition site; other site 932919002227 dimerization interface [polypeptide binding]; other site 932919002228 flagellin; Provisional; Region: PRK12805 932919002229 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 932919002230 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 932919002231 Response regulator receiver domain; Region: Response_reg; pfam00072 932919002232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919002233 active site 932919002234 phosphorylation site [posttranslational modification] 932919002235 intermolecular recognition site; other site 932919002236 dimerization interface [polypeptide binding]; other site 932919002237 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 932919002238 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 932919002239 putative binding surface; other site 932919002240 active site 932919002241 P2 response regulator binding domain; Region: P2; pfam07194 932919002242 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 932919002243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919002244 ATP binding site [chemical binding]; other site 932919002245 Mg2+ binding site [ion binding]; other site 932919002246 G-X-G motif; other site 932919002247 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 932919002248 flagellar motor switch protein; Validated; Region: PRK06788 932919002249 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 932919002250 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 932919002251 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 932919002252 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 932919002253 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 932919002254 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 932919002255 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 932919002256 flagellar motor switch protein; Validated; Region: PRK06789 932919002257 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 932919002258 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 932919002259 flagellar motor switch protein; Reviewed; Region: PRK06782 932919002260 CheC-like family; Region: CheC; pfam04509 932919002261 CheC-like family; Region: CheC; pfam04509 932919002262 Chemotaxis phosphatase CheX; Region: CheX; cl15816 932919002263 CheC-like family; Region: CheC; pfam04509 932919002264 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 932919002265 Protein of unknown function (DUF327); Region: DUF327; pfam03885 932919002266 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 932919002267 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 932919002268 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 932919002269 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 932919002270 flagellar capping protein; Validated; Region: fliD; PRK06798 932919002271 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 932919002272 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 932919002273 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 932919002274 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 932919002275 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 932919002276 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 932919002277 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 932919002278 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 932919002279 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 932919002280 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 932919002281 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 932919002282 FliG C-terminal domain; Region: FliG_C; pfam01706 932919002283 flagellar assembly protein H; Validated; Region: fliH; PRK06800 932919002284 Flagellar assembly protein FliH; Region: FliH; pfam02108 932919002285 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 932919002286 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 932919002287 Walker A motif; other site 932919002288 ATP binding site [chemical binding]; other site 932919002289 Walker B motif; other site 932919002290 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 932919002291 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 932919002292 N-acetyl-D-glucosamine binding site [chemical binding]; other site 932919002293 catalytic residue [active] 932919002294 Predicted transcriptional regulators [Transcription]; Region: COG1695 932919002295 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 932919002296 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 932919002297 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 932919002298 pyruvate oxidase; Provisional; Region: PRK08611 932919002299 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 932919002300 PYR/PP interface [polypeptide binding]; other site 932919002301 dimer interface [polypeptide binding]; other site 932919002302 tetramer interface [polypeptide binding]; other site 932919002303 TPP binding site [chemical binding]; other site 932919002304 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 932919002305 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 932919002306 TPP-binding site [chemical binding]; other site 932919002307 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 932919002308 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 932919002309 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932919002310 dimerization interface [polypeptide binding]; other site 932919002311 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932919002312 dimer interface [polypeptide binding]; other site 932919002313 putative CheW interface [polypeptide binding]; other site 932919002314 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 932919002315 putative active site [active] 932919002316 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 932919002317 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 932919002318 glutaminase active site [active] 932919002319 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 932919002320 dimer interface [polypeptide binding]; other site 932919002321 active site 932919002322 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 932919002323 dimer interface [polypeptide binding]; other site 932919002324 active site 932919002325 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 932919002326 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 932919002327 active site 932919002328 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 932919002329 GIY-YIG motif/motif A; other site 932919002330 Leucine rich repeat; Region: LRR_8; pfam13855 932919002331 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919002332 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919002333 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919002334 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932919002335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919002336 non-specific DNA binding site [nucleotide binding]; other site 932919002337 salt bridge; other site 932919002338 sequence-specific DNA binding site [nucleotide binding]; other site 932919002339 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919002340 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932919002341 ligand binding site [chemical binding]; other site 932919002342 flexible hinge region; other site 932919002343 Predicted transcriptional regulators [Transcription]; Region: COG1725 932919002344 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919002345 DNA-binding site [nucleotide binding]; DNA binding site 932919002346 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 932919002347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919002348 Walker A/P-loop; other site 932919002349 ATP binding site [chemical binding]; other site 932919002350 Q-loop/lid; other site 932919002351 ABC transporter signature motif; other site 932919002352 Walker B; other site 932919002353 D-loop; other site 932919002354 H-loop/switch region; other site 932919002355 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932919002356 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932919002357 Walker A/P-loop; other site 932919002358 ATP binding site [chemical binding]; other site 932919002359 Q-loop/lid; other site 932919002360 ABC transporter signature motif; other site 932919002361 Walker B; other site 932919002362 D-loop; other site 932919002363 H-loop/switch region; other site 932919002364 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932919002365 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 932919002366 FtsX-like permease family; Region: FtsX; pfam02687 932919002367 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 932919002368 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919002369 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 932919002370 ligand binding site [chemical binding]; other site 932919002371 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 932919002372 non-specific DNA interactions [nucleotide binding]; other site 932919002373 DNA binding site [nucleotide binding] 932919002374 sequence specific DNA binding site [nucleotide binding]; other site 932919002375 putative cAMP binding site [chemical binding]; other site 932919002376 SnoaL-like domain; Region: SnoaL_4; pfam13577 932919002377 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 932919002378 active site 932919002379 catalytic triad [active] 932919002380 oxyanion hole [active] 932919002381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919002382 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 932919002383 Walker A/P-loop; other site 932919002384 ATP binding site [chemical binding]; other site 932919002385 Q-loop/lid; other site 932919002386 ABC transporter signature motif; other site 932919002387 Walker B; other site 932919002388 D-loop; other site 932919002389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932919002390 H-loop/switch region; other site 932919002391 active site 932919002392 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 932919002393 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 932919002394 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 932919002395 Zn binding site [ion binding]; other site 932919002396 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 932919002397 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932919002398 Zn binding site [ion binding]; other site 932919002399 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 932919002400 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932919002401 Zn binding site [ion binding]; other site 932919002402 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 932919002403 Zn binding site [ion binding]; other site 932919002404 Predicted esterase [General function prediction only]; Region: COG0400 932919002405 putative hydrolase; Provisional; Region: PRK11460 932919002406 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 932919002407 GTPases [General function prediction only]; Region: HflX; COG2262 932919002408 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 932919002409 HflX GTPase family; Region: HflX; cd01878 932919002410 G1 box; other site 932919002411 GTP/Mg2+ binding site [chemical binding]; other site 932919002412 Switch I region; other site 932919002413 G2 box; other site 932919002414 G3 box; other site 932919002415 Switch II region; other site 932919002416 G4 box; other site 932919002417 G5 box; other site 932919002418 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 932919002419 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 932919002420 putative active site [active] 932919002421 putative metal binding site [ion binding]; other site 932919002422 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 932919002423 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 932919002424 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 932919002425 Uncharacterized conserved protein [Function unknown]; Region: COG3538 932919002426 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 932919002427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 932919002428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919002429 putative PBP binding loops; other site 932919002430 ABC-ATPase subunit interface; other site 932919002431 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932919002432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919002433 dimer interface [polypeptide binding]; other site 932919002434 conserved gate region; other site 932919002435 putative PBP binding loops; other site 932919002436 ABC-ATPase subunit interface; other site 932919002437 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 932919002438 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 932919002439 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 932919002440 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919002441 DNA-binding site [nucleotide binding]; DNA binding site 932919002442 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932919002443 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 932919002444 ligand binding site [chemical binding]; other site 932919002445 dimerization interface [polypeptide binding]; other site 932919002446 Transcriptional regulators [Transcription]; Region: GntR; COG1802 932919002447 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919002448 DNA-binding site [nucleotide binding]; DNA binding site 932919002449 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 932919002450 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 932919002451 putative NADP binding site [chemical binding]; other site 932919002452 putative dimer interface [polypeptide binding]; other site 932919002453 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 932919002454 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 932919002455 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932919002456 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932919002457 nucleotide binding site [chemical binding]; other site 932919002458 Predicted membrane protein [Function unknown]; Region: COG4811 932919002459 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 932919002460 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 932919002461 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 932919002462 active site 932919002463 phosphorylation site [posttranslational modification] 932919002464 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 932919002465 active pocket/dimerization site; other site 932919002466 active site 932919002467 phosphorylation site [posttranslational modification] 932919002468 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 932919002469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919002470 Walker A motif; other site 932919002471 ATP binding site [chemical binding]; other site 932919002472 Walker B motif; other site 932919002473 arginine finger; other site 932919002474 Transcriptional antiterminator [Transcription]; Region: COG3933 932919002475 PRD domain; Region: PRD; pfam00874 932919002476 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 932919002477 active pocket/dimerization site; other site 932919002478 active site 932919002479 phosphorylation site [posttranslational modification] 932919002480 PRD domain; Region: PRD; pfam00874 932919002481 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 932919002482 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 932919002483 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 932919002484 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 932919002485 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 932919002486 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 932919002487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 932919002488 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 932919002489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 932919002490 Leucine rich repeat; Region: LRR_8; pfam13855 932919002491 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919002492 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919002493 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919002494 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919002495 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919002496 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919002497 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 932919002498 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 932919002499 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 932919002500 putative deacylase active site [active] 932919002501 Predicted amidohydrolase [General function prediction only]; Region: COG0388 932919002502 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 932919002503 active site 932919002504 catalytic triad [active] 932919002505 dimer interface [polypeptide binding]; other site 932919002506 Protein of unknown function (DUF554); Region: DUF554; pfam04474 932919002507 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 932919002508 NADH(P)-binding; Region: NAD_binding_10; pfam13460 932919002509 NAD binding site [chemical binding]; other site 932919002510 substrate binding site [chemical binding]; other site 932919002511 putative active site [active] 932919002512 Predicted permeases [General function prediction only]; Region: RarD; COG2962 932919002513 EamA-like transporter family; Region: EamA; pfam00892 932919002514 Uncharacterized conserved protein [Function unknown]; Region: COG2353 932919002515 Transcriptional regulators [Transcription]; Region: MarR; COG1846 932919002516 MarR family; Region: MarR_2; pfam12802 932919002517 lysine transporter; Provisional; Region: PRK10836 932919002518 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932919002519 PAS domain; Region: PAS_9; pfam13426 932919002520 putative active site [active] 932919002521 heme pocket [chemical binding]; other site 932919002522 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 932919002523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 932919002524 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 932919002525 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 932919002526 synthetase active site [active] 932919002527 NTP binding site [chemical binding]; other site 932919002528 metal binding site [ion binding]; metal-binding site 932919002529 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 932919002530 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 932919002531 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932919002532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919002533 non-specific DNA binding site [nucleotide binding]; other site 932919002534 salt bridge; other site 932919002535 sequence-specific DNA binding site [nucleotide binding]; other site 932919002536 Cupin domain; Region: Cupin_2; pfam07883 932919002537 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 932919002538 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 932919002539 Walker A/P-loop; other site 932919002540 ATP binding site [chemical binding]; other site 932919002541 Q-loop/lid; other site 932919002542 ABC transporter signature motif; other site 932919002543 Walker B; other site 932919002544 D-loop; other site 932919002545 H-loop/switch region; other site 932919002546 TOBE domain; Region: TOBE_2; pfam08402 932919002547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 932919002548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919002549 putative PBP binding loops; other site 932919002550 ABC-ATPase subunit interface; other site 932919002551 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 932919002552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919002553 dimer interface [polypeptide binding]; other site 932919002554 conserved gate region; other site 932919002555 putative PBP binding loops; other site 932919002556 ABC-ATPase subunit interface; other site 932919002557 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 932919002558 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 932919002559 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 932919002560 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 932919002561 active site 932919002562 zinc binding site [ion binding]; other site 932919002563 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 932919002564 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932919002565 Zn2+ binding site [ion binding]; other site 932919002566 Mg2+ binding site [ion binding]; other site 932919002567 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932919002568 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932919002569 nucleotide binding site [chemical binding]; other site 932919002570 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 932919002571 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 932919002572 FMN binding site [chemical binding]; other site 932919002573 substrate binding site [chemical binding]; other site 932919002574 putative catalytic residue [active] 932919002575 Transcriptional regulators [Transcription]; Region: MarR; COG1846 932919002576 MarR family; Region: MarR_2; pfam12802 932919002577 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 932919002578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919002579 Coenzyme A binding pocket [chemical binding]; other site 932919002580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 932919002581 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 932919002582 dimer interface [polypeptide binding]; other site 932919002583 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932919002584 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 932919002585 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 932919002586 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932919002587 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 932919002588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919002589 motif II; other site 932919002590 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 932919002591 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932919002592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919002593 Coenzyme A binding pocket [chemical binding]; other site 932919002594 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 932919002595 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 932919002596 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 932919002597 DNA binding residues [nucleotide binding] 932919002598 putative dimer interface [polypeptide binding]; other site 932919002599 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932919002600 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932919002601 active site 932919002602 catalytic tetrad [active] 932919002603 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 932919002604 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 932919002605 homodimer interface [polypeptide binding]; other site 932919002606 catalytic residues [active] 932919002607 NAD binding site [chemical binding]; other site 932919002608 substrate binding pocket [chemical binding]; other site 932919002609 flexible flap; other site 932919002610 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 932919002611 PhoU domain; Region: PhoU; pfam01895 932919002612 PhoU domain; Region: PhoU; pfam01895 932919002613 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 932919002614 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 932919002615 dimer interface [polypeptide binding]; other site 932919002616 PYR/PP interface [polypeptide binding]; other site 932919002617 TPP binding site [chemical binding]; other site 932919002618 substrate binding site [chemical binding]; other site 932919002619 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 932919002620 Domain of unknown function; Region: EKR; smart00890 932919002621 4Fe-4S binding domain; Region: Fer4_6; pfam12837 932919002622 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 932919002623 TPP-binding site [chemical binding]; other site 932919002624 dimer interface [polypeptide binding]; other site 932919002625 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 932919002626 Predicted permeases [General function prediction only]; Region: COG0679 932919002627 Helix-turn-helix domain; Region: HTH_28; pfam13518 932919002628 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919002629 non-specific DNA binding site [nucleotide binding]; other site 932919002630 salt bridge; other site 932919002631 sequence-specific DNA binding site [nucleotide binding]; other site 932919002632 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 932919002633 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919002634 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919002635 Predicted membrane protein [Function unknown]; Region: COG3223 932919002636 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932919002637 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932919002638 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 932919002639 Walker A/P-loop; other site 932919002640 ATP binding site [chemical binding]; other site 932919002641 Q-loop/lid; other site 932919002642 ABC transporter signature motif; other site 932919002643 Walker B; other site 932919002644 D-loop; other site 932919002645 H-loop/switch region; other site 932919002646 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 932919002647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919002648 putative substrate translocation pore; other site 932919002649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919002650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919002651 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932919002652 putative substrate translocation pore; other site 932919002653 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932919002654 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932919002655 putative DNA binding site [nucleotide binding]; other site 932919002656 putative Zn2+ binding site [ion binding]; other site 932919002657 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 932919002658 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 932919002659 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932919002660 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 932919002661 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919002662 motif II; other site 932919002663 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 932919002664 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919002665 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919002666 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919002667 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919002668 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919002669 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919002670 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919002671 Predicted membrane protein [Function unknown]; Region: COG3326 932919002672 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 932919002673 homotrimer interaction site [polypeptide binding]; other site 932919002674 putative active site [active] 932919002675 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 932919002676 substrate binding site [chemical binding]; other site 932919002677 zinc-binding site [ion binding]; other site 932919002678 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 932919002679 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 932919002680 GIY-YIG motif/motif A; other site 932919002681 active site 932919002682 catalytic site [active] 932919002683 putative DNA binding site [nucleotide binding]; other site 932919002684 metal binding site [ion binding]; metal-binding site 932919002685 UvrB/uvrC motif; Region: UVR; pfam02151 932919002686 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932919002687 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932919002688 substrate binding pocket [chemical binding]; other site 932919002689 membrane-bound complex binding site; other site 932919002690 hinge residues; other site 932919002691 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932919002692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919002693 dimer interface [polypeptide binding]; other site 932919002694 conserved gate region; other site 932919002695 putative PBP binding loops; other site 932919002696 ABC-ATPase subunit interface; other site 932919002697 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 932919002698 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 932919002699 Walker A/P-loop; other site 932919002700 ATP binding site [chemical binding]; other site 932919002701 Q-loop/lid; other site 932919002702 ABC transporter signature motif; other site 932919002703 Walker B; other site 932919002704 D-loop; other site 932919002705 H-loop/switch region; other site 932919002706 amidase; Provisional; Region: PRK11910 932919002707 Amidase; Region: Amidase; cl11426 932919002708 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932919002709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932919002710 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 932919002711 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 932919002712 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 932919002713 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 932919002714 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 932919002715 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 932919002716 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 932919002717 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932919002718 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 932919002719 Esterase/lipase [General function prediction only]; Region: COG1647 932919002720 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932919002721 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932919002722 DNA binding site [nucleotide binding] 932919002723 domain linker motif; other site 932919002724 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 932919002725 putative dimerization interface [polypeptide binding]; other site 932919002726 putative ligand binding site [chemical binding]; other site 932919002727 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 932919002728 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932919002729 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 932919002730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919002731 dimer interface [polypeptide binding]; other site 932919002732 conserved gate region; other site 932919002733 putative PBP binding loops; other site 932919002734 ABC-ATPase subunit interface; other site 932919002735 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932919002736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919002737 dimer interface [polypeptide binding]; other site 932919002738 conserved gate region; other site 932919002739 ABC-ATPase subunit interface; other site 932919002740 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 932919002741 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 932919002742 Ca binding site [ion binding]; other site 932919002743 active site 932919002744 catalytic site [active] 932919002745 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 932919002746 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 932919002747 active site 932919002748 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 932919002749 active site 932919002750 substrate binding site [chemical binding]; other site 932919002751 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 932919002752 metal binding site [ion binding]; metal-binding site 932919002753 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 932919002754 DEAD-like helicases superfamily; Region: DEXDc; smart00487 932919002755 ATP binding site [chemical binding]; other site 932919002756 Mg++ binding site [ion binding]; other site 932919002757 motif III; other site 932919002758 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932919002759 nucleotide binding region [chemical binding]; other site 932919002760 ATP-binding site [chemical binding]; other site 932919002761 QueT transporter; Region: QueT; cl01932 932919002762 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 932919002763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 932919002764 Predicted transcriptional regulators [Transcription]; Region: COG1733 932919002765 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 932919002766 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 932919002767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919002768 putative substrate translocation pore; other site 932919002769 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932919002770 PRD domain; Region: PRD; pfam00874 932919002771 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932919002772 active site 932919002773 P-loop; other site 932919002774 phosphorylation site [posttranslational modification] 932919002775 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919002776 active site 932919002777 phosphorylation site [posttranslational modification] 932919002778 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932919002779 methionine cluster; other site 932919002780 active site 932919002781 phosphorylation site [posttranslational modification] 932919002782 metal binding site [ion binding]; metal-binding site 932919002783 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932919002784 active site 932919002785 P-loop; other site 932919002786 phosphorylation site [posttranslational modification] 932919002787 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932919002788 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932919002789 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 932919002790 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 932919002791 active site 932919002792 trimer interface [polypeptide binding]; other site 932919002793 allosteric site; other site 932919002794 active site lid [active] 932919002795 hexamer (dimer of trimers) interface [polypeptide binding]; other site 932919002796 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932919002797 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932919002798 active site 932919002799 catalytic tetrad [active] 932919002800 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 932919002801 Collagen binding domain; Region: Collagen_bind; pfam05737 932919002802 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932919002803 Uncharacterized conserved protein [Function unknown]; Region: COG3402 932919002804 Predicted membrane protein [Function unknown]; Region: COG3428 932919002805 Bacterial PH domain; Region: DUF304; pfam03703 932919002806 Bacterial PH domain; Region: DUF304; pfam03703 932919002807 Bacterial PH domain; Region: DUF304; pfam03703 932919002808 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 932919002809 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 932919002810 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 932919002811 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 932919002812 active site 932919002813 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 932919002814 dimer interface [polypeptide binding]; other site 932919002815 substrate binding site [chemical binding]; other site 932919002816 catalytic residues [active] 932919002817 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 932919002818 PemK-like protein; Region: PemK; pfam02452 932919002819 Rsbr N terminal; Region: Rsbr_N; pfam08678 932919002820 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 932919002821 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 932919002822 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 932919002823 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 932919002824 ATP binding site [chemical binding]; other site 932919002825 Mg2+ binding site [ion binding]; other site 932919002826 G-X-G motif; other site 932919002827 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 932919002828 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 932919002829 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 932919002830 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 932919002831 anti sigma factor interaction site; other site 932919002832 regulatory phosphorylation site [posttranslational modification]; other site 932919002833 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 932919002834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919002835 ATP binding site [chemical binding]; other site 932919002836 Mg2+ binding site [ion binding]; other site 932919002837 G-X-G motif; other site 932919002838 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 932919002839 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932919002840 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 932919002841 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 932919002842 DNA binding residues [nucleotide binding] 932919002843 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 932919002844 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 932919002845 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 932919002846 Sulfate transporter family; Region: Sulfate_transp; pfam00916 932919002847 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 932919002848 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 932919002849 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 932919002850 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 932919002851 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 932919002852 RNA binding site [nucleotide binding]; other site 932919002853 hypothetical protein; Provisional; Region: PRK04351 932919002854 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 932919002855 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 932919002856 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 932919002857 Uncharacterized conserved protein [Function unknown]; Region: COG5646 932919002858 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932919002859 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932919002860 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932919002861 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919002862 DNA-binding site [nucleotide binding]; DNA binding site 932919002863 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 932919002864 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 932919002865 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 932919002866 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 932919002867 glutathione reductase; Validated; Region: PRK06116 932919002868 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932919002869 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932919002870 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 932919002871 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932919002872 catalytic core [active] 932919002873 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 932919002874 Domain of unknown function DUF20; Region: UPF0118; pfam01594 932919002875 Predicted transcriptional regulators [Transcription]; Region: COG1725 932919002876 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919002877 DNA-binding site [nucleotide binding]; DNA binding site 932919002878 Predicted membrane protein [General function prediction only]; Region: COG4194 932919002879 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 932919002880 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 932919002881 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 932919002882 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 932919002883 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 932919002884 tetramerization interface [polypeptide binding]; other site 932919002885 NAD(P) binding site [chemical binding]; other site 932919002886 catalytic residues [active] 932919002887 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 932919002888 active site 932919002889 P-loop; other site 932919002890 phosphorylation site [posttranslational modification] 932919002891 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932919002892 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932919002893 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932919002894 methionine cluster; other site 932919002895 active site 932919002896 phosphorylation site [posttranslational modification] 932919002897 metal binding site [ion binding]; metal-binding site 932919002898 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932919002899 beta-galactosidase; Region: BGL; TIGR03356 932919002900 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932919002901 Mga helix-turn-helix domain; Region: Mga; pfam05043 932919002902 PRD domain; Region: PRD; pfam00874 932919002903 PRD domain; Region: PRD; pfam00874 932919002904 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919002905 active site 932919002906 phosphorylation site [posttranslational modification] 932919002907 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 932919002908 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932919002909 ABC transporter; Region: ABC_tran_2; pfam12848 932919002910 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932919002911 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 932919002912 Predicted permeases [General function prediction only]; Region: COG0701 932919002913 Predicted membrane protein [Function unknown]; Region: COG3689 932919002914 pantothenate kinase; Provisional; Region: PRK05439 932919002915 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 932919002916 ATP-binding site [chemical binding]; other site 932919002917 CoA-binding site [chemical binding]; other site 932919002918 Mg2+-binding site [ion binding]; other site 932919002919 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 932919002920 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 932919002921 Walker A/P-loop; other site 932919002922 ATP binding site [chemical binding]; other site 932919002923 Q-loop/lid; other site 932919002924 ABC transporter signature motif; other site 932919002925 Walker B; other site 932919002926 D-loop; other site 932919002927 H-loop/switch region; other site 932919002928 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 932919002929 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 932919002930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932919002931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932919002932 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 932919002933 Domain of unknown function (DUF373); Region: DUF373; cl12079 932919002934 Sulfatase; Region: Sulfatase; pfam00884 932919002935 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 932919002936 active site 932919002937 DNA binding site [nucleotide binding] 932919002938 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 932919002939 active site 932919002940 catalytic site [active] 932919002941 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 932919002942 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 932919002943 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 932919002944 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 932919002945 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 932919002946 Uncharacterized conserved protein [Function unknown]; Region: COG0398 932919002947 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 932919002948 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 932919002949 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 932919002950 Ligand binding site; other site 932919002951 Putative Catalytic site; other site 932919002952 DXD motif; other site 932919002953 epoxyqueuosine reductase; Region: TIGR00276 932919002954 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 932919002955 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 932919002956 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 932919002957 dimer interface [polypeptide binding]; other site 932919002958 FMN binding site [chemical binding]; other site 932919002959 NADPH bind site [chemical binding]; other site 932919002960 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 932919002961 Low molecular weight phosphatase family; Region: LMWPc; cd00115 932919002962 active site 932919002963 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 932919002964 HSP90 family protein; Provisional; Region: PRK14083 932919002965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919002966 ATP binding site [chemical binding]; other site 932919002967 Mg2+ binding site [ion binding]; other site 932919002968 G-X-G motif; other site 932919002969 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 932919002970 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 932919002971 dimerization interface [polypeptide binding]; other site 932919002972 DPS ferroxidase diiron center [ion binding]; other site 932919002973 ion pore; other site 932919002974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 932919002975 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 932919002976 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932919002977 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 932919002978 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 932919002979 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 932919002980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919002981 putative substrate translocation pore; other site 932919002982 Transcriptional regulators [Transcription]; Region: FadR; COG2186 932919002983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919002984 DNA-binding site [nucleotide binding]; DNA binding site 932919002985 FCD domain; Region: FCD; pfam07729 932919002986 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 932919002987 Domain of unknown function DUF20; Region: UPF0118; pfam01594 932919002988 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 932919002989 PGAP1-like protein; Region: PGAP1; pfam07819 932919002990 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 932919002991 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 932919002992 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 932919002993 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 932919002994 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 932919002995 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 932919002996 active site 932919002997 dimer interface [polypeptide binding]; other site 932919002998 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 932919002999 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 932919003000 active site 932919003001 trimer interface [polypeptide binding]; other site 932919003002 allosteric site; other site 932919003003 active site lid [active] 932919003004 hexamer (dimer of trimers) interface [polypeptide binding]; other site 932919003005 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932919003006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919003007 DNA-binding site [nucleotide binding]; DNA binding site 932919003008 UTRA domain; Region: UTRA; pfam07702 932919003009 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 932919003010 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 932919003011 Mg++ binding site [ion binding]; other site 932919003012 putative catalytic motif [active] 932919003013 substrate binding site [chemical binding]; other site 932919003014 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 932919003015 Peptidase family U32; Region: Peptidase_U32; pfam01136 932919003016 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 932919003017 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 932919003018 Peptidase family U32; Region: Peptidase_U32; pfam01136 932919003019 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 932919003020 heat shock protein HtpX; Provisional; Region: PRK04897 932919003021 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 932919003022 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 932919003023 catalytic residues [active] 932919003024 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 932919003025 putative active site [active] 932919003026 putative metal binding residues [ion binding]; other site 932919003027 signature motif; other site 932919003028 putative triphosphate binding site [ion binding]; other site 932919003029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932919003030 TPR motif; other site 932919003031 binding surface 932919003032 Tetratrico peptide repeat; Region: TPR_5; pfam12688 932919003033 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 932919003034 synthetase active site [active] 932919003035 NTP binding site [chemical binding]; other site 932919003036 metal binding site [ion binding]; metal-binding site 932919003037 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 932919003038 ATP-NAD kinase; Region: NAD_kinase; pfam01513 932919003039 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 932919003040 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 932919003041 active site 932919003042 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 932919003043 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 932919003044 NAD binding site [chemical binding]; other site 932919003045 homotetramer interface [polypeptide binding]; other site 932919003046 homodimer interface [polypeptide binding]; other site 932919003047 substrate binding site [chemical binding]; other site 932919003048 active site 932919003049 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 932919003050 DltD N-terminal region; Region: DltD_N; pfam04915 932919003051 DltD central region; Region: DltD_M; pfam04918 932919003052 DltD C-terminal region; Region: DltD_C; pfam04914 932919003053 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 932919003054 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 932919003055 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 932919003056 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 932919003057 acyl-activating enzyme (AAE) consensus motif; other site 932919003058 AMP binding site [chemical binding]; other site 932919003059 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 932919003060 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 932919003061 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932919003062 active site 932919003063 dimer interface [polypeptide binding]; other site 932919003064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919003065 Coenzyme A binding pocket [chemical binding]; other site 932919003066 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 932919003067 Putative esterase; Region: Esterase; pfam00756 932919003068 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 932919003069 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 932919003070 homodimer interface [polypeptide binding]; other site 932919003071 substrate-cofactor binding pocket; other site 932919003072 catalytic residue [active] 932919003073 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 932919003074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919003075 Walker A/P-loop; other site 932919003076 ATP binding site [chemical binding]; other site 932919003077 Q-loop/lid; other site 932919003078 ABC transporter signature motif; other site 932919003079 Walker B; other site 932919003080 D-loop; other site 932919003081 H-loop/switch region; other site 932919003082 ABC-2 type transporter; Region: ABC2_membrane; cl17235 932919003083 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 932919003084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919003085 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932919003086 putative substrate translocation pore; other site 932919003087 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 932919003088 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 932919003089 putative oligomer interface [polypeptide binding]; other site 932919003090 putative active site [active] 932919003091 metal binding site [ion binding]; metal-binding site 932919003092 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 932919003093 catalytic residues [active] 932919003094 dimer interface [polypeptide binding]; other site 932919003095 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 932919003096 LytTr DNA-binding domain; Region: LytTR; pfam04397 932919003097 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 932919003098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919003099 Walker A/P-loop; other site 932919003100 ATP binding site [chemical binding]; other site 932919003101 Q-loop/lid; other site 932919003102 ABC transporter signature motif; other site 932919003103 Walker B; other site 932919003104 D-loop; other site 932919003105 H-loop/switch region; other site 932919003106 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 932919003107 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 932919003108 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 932919003109 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 932919003110 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 932919003111 G1 box; other site 932919003112 putative GEF interaction site [polypeptide binding]; other site 932919003113 GTP/Mg2+ binding site [chemical binding]; other site 932919003114 Switch I region; other site 932919003115 G2 box; other site 932919003116 G3 box; other site 932919003117 Switch II region; other site 932919003118 G4 box; other site 932919003119 G5 box; other site 932919003120 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 932919003121 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932919003122 MarR family; Region: MarR_2; cl17246 932919003123 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 932919003124 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 932919003125 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 932919003126 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 932919003127 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 932919003128 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 932919003129 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 932919003130 Acyltransferase family; Region: Acyl_transf_3; pfam01757 932919003131 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 932919003132 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 932919003133 DNA binding site [nucleotide binding] 932919003134 active site 932919003135 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 932919003136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919003137 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 932919003138 Walker A motif; other site 932919003139 ATP binding site [chemical binding]; other site 932919003140 Walker B motif; other site 932919003141 arginine finger; other site 932919003142 UvrB/uvrC motif; Region: UVR; pfam02151 932919003143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919003144 Walker A motif; other site 932919003145 ATP binding site [chemical binding]; other site 932919003146 Walker B motif; other site 932919003147 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 932919003148 CAAX protease self-immunity; Region: Abi; pfam02517 932919003149 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 932919003150 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 932919003151 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 932919003152 nucleotide binding site [chemical binding]; other site 932919003153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 932919003154 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 932919003155 dimerization domain swap beta strand [polypeptide binding]; other site 932919003156 regulatory protein interface [polypeptide binding]; other site 932919003157 active site 932919003158 regulatory phosphorylation site [posttranslational modification]; other site 932919003159 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 932919003160 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 932919003161 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 932919003162 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 932919003163 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 932919003164 Uncharacterized conserved protein [Function unknown]; Region: COG1434 932919003165 putative active site [active] 932919003166 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 932919003167 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 932919003168 aminotransferase A; Validated; Region: PRK07683 932919003169 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932919003170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919003171 homodimer interface [polypeptide binding]; other site 932919003172 catalytic residue [active] 932919003173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 932919003174 FOG: CBS domain [General function prediction only]; Region: COG0517 932919003175 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 932919003176 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932919003177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932919003178 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 932919003179 dimerization interface [polypeptide binding]; other site 932919003180 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 932919003181 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 932919003182 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 932919003183 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 932919003184 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 932919003185 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 932919003186 metal binding site [ion binding]; metal-binding site 932919003187 putative dimer interface [polypeptide binding]; other site 932919003188 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 932919003189 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 932919003190 Mechanosensitive ion channel; Region: MS_channel; pfam00924 932919003191 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 932919003192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919003193 Walker A/P-loop; other site 932919003194 ATP binding site [chemical binding]; other site 932919003195 Q-loop/lid; other site 932919003196 ABC transporter signature motif; other site 932919003197 Walker B; other site 932919003198 D-loop; other site 932919003199 H-loop/switch region; other site 932919003200 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 932919003201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919003202 dimer interface [polypeptide binding]; other site 932919003203 conserved gate region; other site 932919003204 putative PBP binding loops; other site 932919003205 ABC-ATPase subunit interface; other site 932919003206 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 932919003207 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 932919003208 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 932919003209 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 932919003210 HPr interaction site; other site 932919003211 glycerol kinase (GK) interaction site [polypeptide binding]; other site 932919003212 active site 932919003213 phosphorylation site [posttranslational modification] 932919003214 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 932919003215 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 932919003216 S1 domain; Region: S1_2; pfam13509 932919003217 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 932919003218 RNA binding site [nucleotide binding]; other site 932919003219 Predicted membrane protein [Function unknown]; Region: COG4758 932919003220 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 932919003221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 932919003222 Histidine kinase; Region: HisKA_3; pfam07730 932919003223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919003224 ATP binding site [chemical binding]; other site 932919003225 Mg2+ binding site [ion binding]; other site 932919003226 G-X-G motif; other site 932919003227 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 932919003228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919003229 active site 932919003230 phosphorylation site [posttranslational modification] 932919003231 intermolecular recognition site; other site 932919003232 dimerization interface [polypeptide binding]; other site 932919003233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 932919003234 DNA binding residues [nucleotide binding] 932919003235 dimerization interface [polypeptide binding]; other site 932919003236 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 932919003237 TrkA-N domain; Region: TrkA_N; pfam02254 932919003238 TrkA-C domain; Region: TrkA_C; pfam02080 932919003239 Predicted membrane protein [Function unknown]; Region: COG1289 932919003240 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 932919003241 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 932919003242 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 932919003243 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 932919003244 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 932919003245 hypothetical protein; Provisional; Region: PRK13667 932919003246 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932919003247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919003248 active site 932919003249 motif I; other site 932919003250 motif II; other site 932919003251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919003252 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932919003253 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932919003254 DNA binding site [nucleotide binding] 932919003255 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 932919003256 ligand binding site [chemical binding]; other site 932919003257 dimerization interface [polypeptide binding]; other site 932919003258 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 932919003259 hexamer (dimer of trimers) interface [polypeptide binding]; other site 932919003260 trimer interface [polypeptide binding]; other site 932919003261 substrate binding site [chemical binding]; other site 932919003262 Mn binding site [ion binding]; other site 932919003263 transketolase; Reviewed; Region: PRK05899 932919003264 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 932919003265 TPP-binding site [chemical binding]; other site 932919003266 dimer interface [polypeptide binding]; other site 932919003267 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 932919003268 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 932919003269 PYR/PP interface [polypeptide binding]; other site 932919003270 dimer interface [polypeptide binding]; other site 932919003271 TPP binding site [chemical binding]; other site 932919003272 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932919003273 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 932919003274 Uncharacterized subgroup; belongs to the glycerol kinases subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK_1; cd10427 932919003275 N- and C-terminal domain interface [polypeptide binding]; other site 932919003276 active site 932919003277 MgATP binding site [chemical binding]; other site 932919003278 catalytic site [active] 932919003279 metal binding site [ion binding]; metal-binding site 932919003280 putative glycerol binding site [chemical binding]; other site 932919003281 putative homotetramer interface [polypeptide binding]; other site 932919003282 putative homodimer interface [polypeptide binding]; other site 932919003283 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 932919003284 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932919003285 active site turn [active] 932919003286 phosphorylation site [posttranslational modification] 932919003287 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932919003288 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 932919003289 HPr interaction site; other site 932919003290 glycerol kinase (GK) interaction site [polypeptide binding]; other site 932919003291 active site 932919003292 phosphorylation site [posttranslational modification] 932919003293 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 932919003294 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 932919003295 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 932919003296 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 932919003297 GTP binding site; other site 932919003298 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 932919003299 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 932919003300 Walker A/P-loop; other site 932919003301 ATP binding site [chemical binding]; other site 932919003302 Q-loop/lid; other site 932919003303 ABC transporter signature motif; other site 932919003304 Walker B; other site 932919003305 D-loop; other site 932919003306 H-loop/switch region; other site 932919003307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919003308 dimer interface [polypeptide binding]; other site 932919003309 conserved gate region; other site 932919003310 putative PBP binding loops; other site 932919003311 ABC-ATPase subunit interface; other site 932919003312 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 932919003313 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 932919003314 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 932919003315 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 932919003316 dimer interface [polypeptide binding]; other site 932919003317 putative functional site; other site 932919003318 putative MPT binding site; other site 932919003319 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 932919003320 Walker A motif; other site 932919003321 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 932919003322 MoaE homodimer interface [polypeptide binding]; other site 932919003323 MoaD interaction [polypeptide binding]; other site 932919003324 active site residues [active] 932919003325 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 932919003326 MoaE interaction surface [polypeptide binding]; other site 932919003327 MoeB interaction surface [polypeptide binding]; other site 932919003328 thiocarboxylated glycine; other site 932919003329 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 932919003330 trimer interface [polypeptide binding]; other site 932919003331 dimer interface [polypeptide binding]; other site 932919003332 putative active site [active] 932919003333 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 932919003334 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932919003335 FeS/SAM binding site; other site 932919003336 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 932919003337 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 932919003338 MPT binding site; other site 932919003339 trimer interface [polypeptide binding]; other site 932919003340 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 932919003341 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 932919003342 ATP binding site [chemical binding]; other site 932919003343 substrate interface [chemical binding]; other site 932919003344 Flavin Reductases; Region: FlaRed; cl00801 932919003345 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 932919003346 active site 932919003347 catalytic residues [active] 932919003348 metal binding site [ion binding]; metal-binding site 932919003349 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 932919003350 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 932919003351 TPP-binding site [chemical binding]; other site 932919003352 tetramer interface [polypeptide binding]; other site 932919003353 heterodimer interface [polypeptide binding]; other site 932919003354 phosphorylation loop region [posttranslational modification] 932919003355 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 932919003356 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 932919003357 alpha subunit interface [polypeptide binding]; other site 932919003358 TPP binding site [chemical binding]; other site 932919003359 heterodimer interface [polypeptide binding]; other site 932919003360 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932919003361 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 932919003362 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 932919003363 E3 interaction surface; other site 932919003364 lipoyl attachment site [posttranslational modification]; other site 932919003365 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 932919003366 E3 interaction surface; other site 932919003367 lipoyl attachment site [posttranslational modification]; other site 932919003368 e3 binding domain; Region: E3_binding; pfam02817 932919003369 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 932919003370 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 932919003371 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 932919003372 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932919003373 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 932919003374 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 932919003375 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 932919003376 NAD(P) binding site [chemical binding]; other site 932919003377 LDH/MDH dimer interface [polypeptide binding]; other site 932919003378 substrate binding site [chemical binding]; other site 932919003379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476 932919003380 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 932919003381 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 932919003382 catalytic residues [active] 932919003383 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 932919003384 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 932919003385 Cl binding site [ion binding]; other site 932919003386 oligomer interface [polypeptide binding]; other site 932919003387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 932919003388 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 932919003389 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 932919003390 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 932919003391 active site 932919003392 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 932919003393 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 932919003394 G1 box; other site 932919003395 putative GEF interaction site [polypeptide binding]; other site 932919003396 GTP/Mg2+ binding site [chemical binding]; other site 932919003397 Switch I region; other site 932919003398 G2 box; other site 932919003399 G3 box; other site 932919003400 Switch II region; other site 932919003401 G4 box; other site 932919003402 G5 box; other site 932919003403 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 932919003404 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 932919003405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 932919003406 hypothetical protein; Provisional; Region: PRK13666 932919003407 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 932919003408 pyruvate carboxylase; Reviewed; Region: PRK12999 932919003409 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 932919003410 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 932919003411 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 932919003412 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 932919003413 active site 932919003414 catalytic residues [active] 932919003415 metal binding site [ion binding]; metal-binding site 932919003416 homodimer binding site [polypeptide binding]; other site 932919003417 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 932919003418 carboxyltransferase (CT) interaction site; other site 932919003419 biotinylation site [posttranslational modification]; other site 932919003420 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 932919003421 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 932919003422 putative binding site residues; other site 932919003423 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 932919003424 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 932919003425 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 932919003426 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 932919003427 Walker A/P-loop; other site 932919003428 ATP binding site [chemical binding]; other site 932919003429 Q-loop/lid; other site 932919003430 ABC transporter signature motif; other site 932919003431 Walker B; other site 932919003432 D-loop; other site 932919003433 H-loop/switch region; other site 932919003434 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 932919003435 SH3-like domain; Region: SH3_8; pfam13457 932919003436 SH3-like domain; Region: SH3_8; pfam13457 932919003437 SH3-like domain; Region: SH3_8; pfam13457 932919003438 SH3-like domain; Region: SH3_8; pfam13457 932919003439 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 932919003440 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 932919003441 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 932919003442 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 932919003443 active site 932919003444 tetramer interface; other site 932919003445 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 932919003446 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 932919003447 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 932919003448 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932919003449 active site 932919003450 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 932919003451 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 932919003452 substrate binding site; other site 932919003453 tetramer interface; other site 932919003454 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 932919003455 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 932919003456 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 932919003457 NAD binding site [chemical binding]; other site 932919003458 substrate binding site [chemical binding]; other site 932919003459 homodimer interface [polypeptide binding]; other site 932919003460 active site 932919003461 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 932919003462 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 932919003463 NADP binding site [chemical binding]; other site 932919003464 active site 932919003465 putative substrate binding site [chemical binding]; other site 932919003466 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 932919003467 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 932919003468 substrate binding site; other site 932919003469 dimer interface; other site 932919003470 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 932919003471 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 932919003472 putative NAD(P) binding site [chemical binding]; other site 932919003473 putative catalytic Zn binding site [ion binding]; other site 932919003474 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 932919003475 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 932919003476 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 932919003477 active site 932919003478 putative glycosyl transferase; Provisional; Region: PRK10073 932919003479 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932919003480 active site 932919003481 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932919003482 active site 932919003483 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 932919003484 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 932919003485 active site 932919003486 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 932919003487 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 932919003488 homodimer interface [polypeptide binding]; other site 932919003489 NAD binding pocket [chemical binding]; other site 932919003490 ATP binding pocket [chemical binding]; other site 932919003491 Mg binding site [ion binding]; other site 932919003492 active-site loop [active] 932919003493 Uncharacterized conserved protein [Function unknown]; Region: COG1359 932919003494 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 932919003495 active site 932919003496 P-loop; other site 932919003497 phosphorylation site [posttranslational modification] 932919003498 GMP synthase; Reviewed; Region: guaA; PRK00074 932919003499 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 932919003500 AMP/PPi binding site [chemical binding]; other site 932919003501 candidate oxyanion hole; other site 932919003502 catalytic triad [active] 932919003503 potential glutamine specificity residues [chemical binding]; other site 932919003504 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 932919003505 ATP Binding subdomain [chemical binding]; other site 932919003506 Dimerization subdomain; other site 932919003507 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 932919003508 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932919003509 active site 932919003510 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 932919003511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919003512 Walker A/P-loop; other site 932919003513 ATP binding site [chemical binding]; other site 932919003514 Q-loop/lid; other site 932919003515 ABC transporter signature motif; other site 932919003516 Walker B; other site 932919003517 D-loop; other site 932919003518 H-loop/switch region; other site 932919003519 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 932919003520 putative FMN binding site [chemical binding]; other site 932919003521 NADPH bind site [chemical binding]; other site 932919003522 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 932919003523 YcaO-like family; Region: YcaO; pfam02624 932919003524 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 932919003525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932919003526 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932919003527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932919003528 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 932919003529 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 932919003530 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 932919003531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 932919003532 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 932919003533 MepB protein; Region: MepB; cl01985 932919003534 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 932919003535 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 932919003536 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932919003537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919003538 Coenzyme A binding pocket [chemical binding]; other site 932919003539 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 932919003540 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 932919003541 DNA binding residues [nucleotide binding] 932919003542 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 932919003543 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932919003544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919003545 Walker A/P-loop; other site 932919003546 ATP binding site [chemical binding]; other site 932919003547 Q-loop/lid; other site 932919003548 ABC transporter signature motif; other site 932919003549 Walker B; other site 932919003550 D-loop; other site 932919003551 H-loop/switch region; other site 932919003552 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932919003553 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932919003554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919003555 Walker A/P-loop; other site 932919003556 ATP binding site [chemical binding]; other site 932919003557 Q-loop/lid; other site 932919003558 ABC transporter signature motif; other site 932919003559 Walker B; other site 932919003560 D-loop; other site 932919003561 H-loop/switch region; other site 932919003562 Uncharacterized conserved protein [Function unknown]; Region: COG1359 932919003563 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 932919003564 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 932919003565 DNA binding residues [nucleotide binding] 932919003566 putative dimer interface [polypeptide binding]; other site 932919003567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932919003568 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 932919003569 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932919003570 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 932919003571 LRR adjacent; Region: LRR_adjacent; pfam08191 932919003572 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919003573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 932919003574 Clp protease; Region: CLP_protease; pfam00574 932919003575 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 932919003576 oligomer interface [polypeptide binding]; other site 932919003577 active site residues [active] 932919003578 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 932919003579 dimer interface [polypeptide binding]; other site 932919003580 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932919003581 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 932919003582 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 932919003583 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 932919003584 SLBB domain; Region: SLBB; pfam10531 932919003585 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 932919003586 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 932919003587 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 932919003588 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 932919003589 putative hexamer interface [polypeptide binding]; other site 932919003590 putative hexagonal pore; other site 932919003591 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 932919003592 putative hexamer interface [polypeptide binding]; other site 932919003593 putative hexagonal pore; other site 932919003594 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 932919003595 putative hexamer interface [polypeptide binding]; other site 932919003596 putative hexagonal pore; other site 932919003597 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 932919003598 G1 box; other site 932919003599 GTP/Mg2+ binding site [chemical binding]; other site 932919003600 G2 box; other site 932919003601 Switch I region; other site 932919003602 G3 box; other site 932919003603 Switch II region; other site 932919003604 G4 box; other site 932919003605 G5 box; other site 932919003606 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 932919003607 homotrimer interface [polypeptide binding]; other site 932919003608 Walker A motif; other site 932919003609 GTP binding site [chemical binding]; other site 932919003610 Walker B motif; other site 932919003611 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 932919003612 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932919003613 catalytic core [active] 932919003614 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 932919003615 Sensory domain found in PocR; Region: PocR; pfam10114 932919003616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932919003617 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932919003618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932919003619 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 932919003620 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 932919003621 Hexamer interface [polypeptide binding]; other site 932919003622 Hexagonal pore residue; other site 932919003623 propanediol utilization protein PduB; Provisional; Region: PRK15415 932919003624 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 932919003625 putative hexamer interface [polypeptide binding]; other site 932919003626 putative hexagonal pore; other site 932919003627 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 932919003628 putative hexamer interface [polypeptide binding]; other site 932919003629 putative hexagonal pore; other site 932919003630 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 932919003631 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 932919003632 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 932919003633 alpha-beta subunit interface [polypeptide binding]; other site 932919003634 alpha-gamma subunit interface [polypeptide binding]; other site 932919003635 active site 932919003636 substrate and K+ binding site; other site 932919003637 K+ binding site [ion binding]; other site 932919003638 cobalamin binding site [chemical binding]; other site 932919003639 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 932919003640 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 932919003641 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 932919003642 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 932919003643 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 932919003644 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 932919003645 putative hexamer interface [polypeptide binding]; other site 932919003646 putative hexagonal pore; other site 932919003647 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 932919003648 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 932919003649 Hexamer interface [polypeptide binding]; other site 932919003650 Hexagonal pore residue; other site 932919003651 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 932919003652 Propanediol utilisation protein PduL; Region: PduL; pfam06130 932919003653 Propanediol utilisation protein PduL; Region: PduL; pfam06130 932919003654 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 932919003655 Cell division protein FtsA; Region: FtsA; cl17206 932919003656 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 932919003657 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 932919003658 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 932919003659 Hexamer/Pentamer interface [polypeptide binding]; other site 932919003660 central pore; other site 932919003661 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 932919003662 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 932919003663 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 932919003664 putative catalytic cysteine [active] 932919003665 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 932919003666 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 932919003667 putative active site [active] 932919003668 metal binding site [ion binding]; metal-binding site 932919003669 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 932919003670 amphipathic channel; other site 932919003671 Asn-Pro-Ala signature motifs; other site 932919003672 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 932919003673 propionate/acetate kinase; Provisional; Region: PRK12379 932919003674 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 932919003675 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932919003676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919003677 homodimer interface [polypeptide binding]; other site 932919003678 catalytic residue [active] 932919003679 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 932919003680 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 932919003681 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 932919003682 putative active site [active] 932919003683 metal binding site [ion binding]; metal-binding site 932919003684 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 932919003685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919003686 active site 932919003687 phosphorylation site [posttranslational modification] 932919003688 intermolecular recognition site; other site 932919003689 dimerization interface [polypeptide binding]; other site 932919003690 ANTAR domain; Region: ANTAR; pfam03861 932919003691 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 932919003692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 932919003693 Histidine kinase; Region: HisKA_2; pfam07568 932919003694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919003695 ATP binding site [chemical binding]; other site 932919003696 Mg2+ binding site [ion binding]; other site 932919003697 G-X-G motif; other site 932919003698 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 932919003699 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 932919003700 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 932919003701 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 932919003702 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 932919003703 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 932919003704 putative hexamer interface [polypeptide binding]; other site 932919003705 putative hexagonal pore; other site 932919003706 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 932919003707 putative hexamer interface [polypeptide binding]; other site 932919003708 putative hexagonal pore; other site 932919003709 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 932919003710 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 932919003711 Hexamer interface [polypeptide binding]; other site 932919003712 Hexagonal pore residue; other site 932919003713 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 932919003714 putative catalytic cysteine [active] 932919003715 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 932919003716 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 932919003717 Hexamer interface [polypeptide binding]; other site 932919003718 Putative hexagonal pore residue; other site 932919003719 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 932919003720 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 932919003721 Propanediol utilisation protein PduL; Region: PduL; pfam06130 932919003722 Propanediol utilisation protein PduL; Region: PduL; pfam06130 932919003723 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 932919003724 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 932919003725 Hexamer/Pentamer interface [polypeptide binding]; other site 932919003726 central pore; other site 932919003727 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 932919003728 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 932919003729 putative hexamer interface [polypeptide binding]; other site 932919003730 putative hexagonal pore; other site 932919003731 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 932919003732 putative hexamer interface [polypeptide binding]; other site 932919003733 putative hexagonal pore; other site 932919003734 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 932919003735 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 932919003736 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 932919003737 hypothetical protein; Region: PHA01818 932919003738 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932919003739 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932919003740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932919003741 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 932919003742 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 932919003743 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 932919003744 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 932919003745 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 932919003746 catalytic triad [active] 932919003747 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 932919003748 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 932919003749 Precorrin-8X methylmutase; Region: CbiC; pfam02570 932919003750 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 932919003751 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 932919003752 active site 932919003753 putative homodimer interface [polypeptide binding]; other site 932919003754 SAM binding site [chemical binding]; other site 932919003755 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 932919003756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919003757 S-adenosylmethionine binding site [chemical binding]; other site 932919003758 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 932919003759 active site 932919003760 SAM binding site [chemical binding]; other site 932919003761 homodimer interface [polypeptide binding]; other site 932919003762 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 932919003763 active site 932919003764 SAM binding site [chemical binding]; other site 932919003765 homodimer interface [polypeptide binding]; other site 932919003766 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 932919003767 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 932919003768 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 932919003769 active site 932919003770 SAM binding site [chemical binding]; other site 932919003771 homodimer interface [polypeptide binding]; other site 932919003772 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 932919003773 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 932919003774 active site 932919003775 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 932919003776 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 932919003777 active site 932919003778 C-terminal domain interface [polypeptide binding]; other site 932919003779 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 932919003780 active site 932919003781 N-terminal domain interface [polypeptide binding]; other site 932919003782 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 932919003783 active site 932919003784 SAM binding site [chemical binding]; other site 932919003785 homodimer interface [polypeptide binding]; other site 932919003786 cobalt transport protein CbiM; Validated; Region: PRK08319 932919003787 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 932919003788 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 932919003789 cobalt transport protein CbiQ; Provisional; Region: PRK15485 932919003790 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 932919003791 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 932919003792 Walker A/P-loop; other site 932919003793 ATP binding site [chemical binding]; other site 932919003794 Q-loop/lid; other site 932919003795 ABC transporter signature motif; other site 932919003796 Walker B; other site 932919003797 D-loop; other site 932919003798 H-loop/switch region; other site 932919003799 cobyric acid synthase; Provisional; Region: PRK00784 932919003800 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 932919003801 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 932919003802 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 932919003803 catalytic triad [active] 932919003804 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 932919003805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 932919003806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 932919003807 AAA domain; Region: AAA_17; cl17253 932919003808 Predicted transcriptional regulators [Transcription]; Region: COG1695 932919003809 Transcriptional regulator PadR-like family; Region: PadR; cl17335 932919003810 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 932919003811 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 932919003812 SH3-like domain; Region: SH3_8; pfam13457 932919003813 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 932919003814 SH3-like domain; Region: SH3_8; pfam13457 932919003815 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 932919003816 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 932919003817 oligomer interface [polypeptide binding]; other site 932919003818 active site 932919003819 metal binding site [ion binding]; metal-binding site 932919003820 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 932919003821 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 932919003822 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 932919003823 Predicted transcriptional regulators [Transcription]; Region: COG1733 932919003824 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 932919003825 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 932919003826 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 932919003827 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 932919003828 dimer interface [polypeptide binding]; other site 932919003829 motif 1; other site 932919003830 active site 932919003831 motif 2; other site 932919003832 motif 3; other site 932919003833 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 932919003834 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 932919003835 putative tRNA-binding site [nucleotide binding]; other site 932919003836 B3/4 domain; Region: B3_4; pfam03483 932919003837 tRNA synthetase B5 domain; Region: B5; smart00874 932919003838 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 932919003839 dimer interface [polypeptide binding]; other site 932919003840 motif 1; other site 932919003841 motif 3; other site 932919003842 motif 2; other site 932919003843 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 932919003844 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932919003845 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932919003846 Walker A/P-loop; other site 932919003847 ATP binding site [chemical binding]; other site 932919003848 Q-loop/lid; other site 932919003849 ABC transporter signature motif; other site 932919003850 Walker B; other site 932919003851 D-loop; other site 932919003852 H-loop/switch region; other site 932919003853 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932919003854 FtsX-like permease family; Region: FtsX; pfam02687 932919003855 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 932919003856 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932919003857 FtsX-like permease family; Region: FtsX; pfam02687 932919003858 Transcriptional regulators [Transcription]; Region: MarR; COG1846 932919003859 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932919003860 putative DNA binding site [nucleotide binding]; other site 932919003861 putative Zn2+ binding site [ion binding]; other site 932919003862 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 932919003863 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 932919003864 ligand binding site [chemical binding]; other site 932919003865 active site 932919003866 UGI interface [polypeptide binding]; other site 932919003867 catalytic site [active] 932919003868 ribonuclease HIII; Provisional; Region: PRK00996 932919003869 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 932919003870 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 932919003871 RNA/DNA hybrid binding site [nucleotide binding]; other site 932919003872 active site 932919003873 Cell division protein ZapA; Region: ZapA; cl01146 932919003874 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 932919003875 Colicin V production protein; Region: Colicin_V; pfam02674 932919003876 hypothetical protein; Provisional; Region: PRK08609 932919003877 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 932919003878 active site 932919003879 primer binding site [nucleotide binding]; other site 932919003880 NTP binding site [chemical binding]; other site 932919003881 metal binding triad [ion binding]; metal-binding site 932919003882 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 932919003883 active site 932919003884 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 932919003885 MutS domain III; Region: MutS_III; pfam05192 932919003886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919003887 Walker A/P-loop; other site 932919003888 ATP binding site [chemical binding]; other site 932919003889 Q-loop/lid; other site 932919003890 ABC transporter signature motif; other site 932919003891 Walker B; other site 932919003892 D-loop; other site 932919003893 H-loop/switch region; other site 932919003894 Smr domain; Region: Smr; pfam01713 932919003895 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 932919003896 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 932919003897 catalytic residues [active] 932919003898 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 932919003899 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 932919003900 GIY-YIG motif/motif A; other site 932919003901 active site 932919003902 catalytic site [active] 932919003903 putative DNA binding site [nucleotide binding]; other site 932919003904 metal binding site [ion binding]; metal-binding site 932919003905 UvrB/uvrC motif; Region: UVR; pfam02151 932919003906 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 932919003907 aspartate kinase; Reviewed; Region: PRK06635 932919003908 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 932919003909 putative nucleotide binding site [chemical binding]; other site 932919003910 putative catalytic residues [active] 932919003911 putative Mg ion binding site [ion binding]; other site 932919003912 putative aspartate binding site [chemical binding]; other site 932919003913 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 932919003914 putative allosteric regulatory site; other site 932919003915 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 932919003916 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 932919003917 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 932919003918 ribonuclease PH; Reviewed; Region: rph; PRK00173 932919003919 Ribonuclease PH; Region: RNase_PH_bact; cd11362 932919003920 hexamer interface [polypeptide binding]; other site 932919003921 active site 932919003922 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 932919003923 active site 932919003924 dimerization interface [polypeptide binding]; other site 932919003925 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 932919003926 active site 932919003927 metal binding site [ion binding]; metal-binding site 932919003928 homotetramer interface [polypeptide binding]; other site 932919003929 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 932919003930 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 932919003931 LRR adjacent; Region: LRR_adjacent; pfam08191 932919003932 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919003933 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919003934 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919003935 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919003936 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919003937 Uncharacterized conserved protein [Function unknown]; Region: COG5361 932919003938 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 932919003939 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 932919003940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 932919003941 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 932919003942 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 932919003943 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 932919003944 dimer interface [polypeptide binding]; other site 932919003945 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932919003946 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932919003947 catalytic core [active] 932919003948 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 932919003949 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 932919003950 ATP binding site [chemical binding]; other site 932919003951 Mg++ binding site [ion binding]; other site 932919003952 motif III; other site 932919003953 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932919003954 nucleotide binding region [chemical binding]; other site 932919003955 ATP-binding site [chemical binding]; other site 932919003956 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 932919003957 RNA binding site [nucleotide binding]; other site 932919003958 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 932919003959 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 932919003960 putative active site [active] 932919003961 nucleotide binding site [chemical binding]; other site 932919003962 nudix motif; other site 932919003963 putative metal binding site [ion binding]; other site 932919003964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919003965 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932919003966 putative substrate translocation pore; other site 932919003967 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919003968 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932919003969 ligand binding site [chemical binding]; other site 932919003970 flexible hinge region; other site 932919003971 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 932919003972 Uncharacterized conserved protein [Function unknown]; Region: COG1284 932919003973 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 932919003974 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 932919003975 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 932919003976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919003977 DNA-binding site [nucleotide binding]; DNA binding site 932919003978 UTRA domain; Region: UTRA; pfam07702 932919003979 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 932919003980 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 932919003981 Ca binding site [ion binding]; other site 932919003982 active site 932919003983 catalytic site [active] 932919003984 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932919003985 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 932919003986 active site turn [active] 932919003987 phosphorylation site [posttranslational modification] 932919003988 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932919003989 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 932919003990 nudix motif; other site 932919003991 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 932919003992 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 932919003993 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 932919003994 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 932919003995 putative catalytic cysteine [active] 932919003996 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 932919003997 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 932919003998 nucleotide binding site [chemical binding]; other site 932919003999 homotetrameric interface [polypeptide binding]; other site 932919004000 putative phosphate binding site [ion binding]; other site 932919004001 putative allosteric binding site; other site 932919004002 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 932919004003 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 932919004004 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932919004005 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919004006 non-specific DNA binding site [nucleotide binding]; other site 932919004007 salt bridge; other site 932919004008 sequence-specific DNA binding site [nucleotide binding]; other site 932919004009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919004010 non-specific DNA binding site [nucleotide binding]; other site 932919004011 salt bridge; other site 932919004012 sequence-specific DNA binding site [nucleotide binding]; other site 932919004013 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 932919004014 active site 932919004015 trigger factor; Provisional; Region: tig; PRK01490 932919004016 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 932919004017 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 932919004018 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 932919004019 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 932919004020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919004021 Walker A motif; other site 932919004022 ATP binding site [chemical binding]; other site 932919004023 Walker B motif; other site 932919004024 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 932919004025 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 932919004026 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 932919004027 Catalytic site [active] 932919004028 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 932919004029 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 932919004030 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 932919004031 Catalytic site [active] 932919004032 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 932919004033 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 932919004034 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 932919004035 Catalytic site [active] 932919004036 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 932919004037 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 932919004038 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 932919004039 GTP/Mg2+ binding site [chemical binding]; other site 932919004040 G4 box; other site 932919004041 G5 box; other site 932919004042 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 932919004043 G1 box; other site 932919004044 G1 box; other site 932919004045 GTP/Mg2+ binding site [chemical binding]; other site 932919004046 Switch I region; other site 932919004047 G2 box; other site 932919004048 G2 box; other site 932919004049 G3 box; other site 932919004050 G3 box; other site 932919004051 Switch II region; other site 932919004052 Switch II region; other site 932919004053 G5 box; other site 932919004054 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 932919004055 RNA/DNA hybrid binding site [nucleotide binding]; other site 932919004056 active site 932919004057 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 932919004058 DNA protecting protein DprA; Region: dprA; TIGR00732 932919004059 DNA topoisomerase I; Validated; Region: PRK05582 932919004060 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 932919004061 active site 932919004062 interdomain interaction site; other site 932919004063 putative metal-binding site [ion binding]; other site 932919004064 nucleotide binding site [chemical binding]; other site 932919004065 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 932919004066 domain I; other site 932919004067 DNA binding groove [nucleotide binding] 932919004068 phosphate binding site [ion binding]; other site 932919004069 domain II; other site 932919004070 domain III; other site 932919004071 nucleotide binding site [chemical binding]; other site 932919004072 catalytic site [active] 932919004073 domain IV; other site 932919004074 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 932919004075 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 932919004076 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 932919004077 Glucose inhibited division protein A; Region: GIDA; pfam01134 932919004078 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 932919004079 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 932919004080 active site 932919004081 DNA binding site [nucleotide binding] 932919004082 Int/Topo IB signature motif; other site 932919004083 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 932919004084 active site 932919004085 HslU subunit interaction site [polypeptide binding]; other site 932919004086 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 932919004087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919004088 Walker A motif; other site 932919004089 ATP binding site [chemical binding]; other site 932919004090 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 932919004091 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 932919004092 transcriptional repressor CodY; Validated; Region: PRK04158 932919004093 CodY GAF-like domain; Region: CodY; pfam06018 932919004094 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 932919004095 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 932919004096 active site 932919004097 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 932919004098 active site 932919004099 catalytic residues [active] 932919004100 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 932919004101 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 932919004102 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 932919004103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919004104 Mg2+ binding site [ion binding]; other site 932919004105 G-X-G motif; other site 932919004106 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 932919004107 anchoring element; other site 932919004108 dimer interface [polypeptide binding]; other site 932919004109 ATP binding site [chemical binding]; other site 932919004110 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 932919004111 active site 932919004112 putative metal-binding site [ion binding]; other site 932919004113 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 932919004114 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 932919004115 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 932919004116 CAP-like domain; other site 932919004117 active site 932919004118 primary dimer interface [polypeptide binding]; other site 932919004119 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932919004120 S-ribosylhomocysteinase; Provisional; Region: PRK02260 932919004121 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 932919004122 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919004123 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 932919004124 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 932919004125 catalytic triad [active] 932919004126 catalytic triad [active] 932919004127 oxyanion hole [active] 932919004128 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 932919004129 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 932919004130 active site 932919004131 catalytic site [active] 932919004132 metal binding site [ion binding]; metal-binding site 932919004133 dimer interface [polypeptide binding]; other site 932919004134 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 932919004135 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 932919004136 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 932919004137 bacterial Hfq-like; Region: Hfq; cd01716 932919004138 hexamer interface [polypeptide binding]; other site 932919004139 Sm1 motif; other site 932919004140 RNA binding site [nucleotide binding]; other site 932919004141 Sm2 motif; other site 932919004142 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 932919004143 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 932919004144 HflX GTPase family; Region: HflX; cd01878 932919004145 G1 box; other site 932919004146 GTP/Mg2+ binding site [chemical binding]; other site 932919004147 Switch I region; other site 932919004148 G2 box; other site 932919004149 G3 box; other site 932919004150 Switch II region; other site 932919004151 G4 box; other site 932919004152 G5 box; other site 932919004153 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 932919004154 Aluminium resistance protein; Region: Alum_res; pfam06838 932919004155 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 932919004156 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 932919004157 DNA binding residues [nucleotide binding] 932919004158 putative dimer interface [polypeptide binding]; other site 932919004159 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 932919004160 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 932919004161 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 932919004162 arsenical pump membrane protein; Provisional; Region: PRK15445 932919004163 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 932919004164 transmembrane helices; other site 932919004165 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932919004166 LexA repressor; Validated; Region: PRK00215 932919004167 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932919004168 putative DNA binding site [nucleotide binding]; other site 932919004169 putative Zn2+ binding site [ion binding]; other site 932919004170 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 932919004171 Catalytic site [active] 932919004172 cell division suppressor protein YneA; Provisional; Region: PRK14125 932919004173 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 932919004174 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 932919004175 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 932919004176 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 932919004177 TPP-binding site [chemical binding]; other site 932919004178 dimer interface [polypeptide binding]; other site 932919004179 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 932919004180 PYR/PP interface [polypeptide binding]; other site 932919004181 dimer interface [polypeptide binding]; other site 932919004182 TPP binding site [chemical binding]; other site 932919004183 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932919004184 hypothetical protein; Provisional; Region: PRK01844 932919004185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 932919004186 Methyltransferase domain; Region: Methyltransf_31; pfam13847 932919004187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919004188 S-adenosylmethionine binding site [chemical binding]; other site 932919004189 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 932919004190 ParB-like nuclease domain; Region: ParBc; pfam02195 932919004191 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 932919004192 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 932919004193 Active Sites [active] 932919004194 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 932919004195 DEAD-like helicases superfamily; Region: DEXDc; smart00487 932919004196 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 932919004197 putative nucleotide binding site [chemical binding]; other site 932919004198 uridine monophosphate binding site [chemical binding]; other site 932919004199 homohexameric interface [polypeptide binding]; other site 932919004200 ribosome recycling factor; Reviewed; Region: frr; PRK00083 932919004201 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 932919004202 hinge region; other site 932919004203 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 932919004204 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 932919004205 catalytic residue [active] 932919004206 putative FPP diphosphate binding site; other site 932919004207 putative FPP binding hydrophobic cleft; other site 932919004208 dimer interface [polypeptide binding]; other site 932919004209 putative IPP diphosphate binding site; other site 932919004210 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 932919004211 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 932919004212 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 932919004213 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 932919004214 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 932919004215 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 932919004216 RIP metalloprotease RseP; Region: TIGR00054 932919004217 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 932919004218 active site 932919004219 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 932919004220 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 932919004221 protein binding site [polypeptide binding]; other site 932919004222 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 932919004223 putative substrate binding region [chemical binding]; other site 932919004224 prolyl-tRNA synthetase; Provisional; Region: PRK09194 932919004225 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 932919004226 dimer interface [polypeptide binding]; other site 932919004227 motif 1; other site 932919004228 active site 932919004229 motif 2; other site 932919004230 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 932919004231 putative deacylase active site [active] 932919004232 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 932919004233 active site 932919004234 motif 3; other site 932919004235 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 932919004236 anticodon binding site; other site 932919004237 DNA polymerase III PolC; Validated; Region: polC; PRK00448 932919004238 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 932919004239 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 932919004240 generic binding surface II; other site 932919004241 generic binding surface I; other site 932919004242 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 932919004243 active site 932919004244 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 932919004245 active site 932919004246 catalytic site [active] 932919004247 substrate binding site [chemical binding]; other site 932919004248 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 932919004249 ribosome maturation protein RimP; Reviewed; Region: PRK00092 932919004250 Sm and related proteins; Region: Sm_like; cl00259 932919004251 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 932919004252 putative oligomer interface [polypeptide binding]; other site 932919004253 putative RNA binding site [nucleotide binding]; other site 932919004254 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 932919004255 NusA N-terminal domain; Region: NusA_N; pfam08529 932919004256 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 932919004257 RNA binding site [nucleotide binding]; other site 932919004258 homodimer interface [polypeptide binding]; other site 932919004259 NusA-like KH domain; Region: KH_5; pfam13184 932919004260 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 932919004261 G-X-X-G motif; other site 932919004262 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 932919004263 putative RNA binding cleft [nucleotide binding]; other site 932919004264 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 932919004265 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 932919004266 translation initiation factor IF-2; Region: IF-2; TIGR00487 932919004267 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 932919004268 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 932919004269 G1 box; other site 932919004270 putative GEF interaction site [polypeptide binding]; other site 932919004271 GTP/Mg2+ binding site [chemical binding]; other site 932919004272 Switch I region; other site 932919004273 G2 box; other site 932919004274 G3 box; other site 932919004275 Switch II region; other site 932919004276 G4 box; other site 932919004277 G5 box; other site 932919004278 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 932919004279 Translation-initiation factor 2; Region: IF-2; pfam11987 932919004280 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 932919004281 Protein of unknown function (DUF503); Region: DUF503; cl00669 932919004282 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 932919004283 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 932919004284 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 932919004285 RNA binding site [nucleotide binding]; other site 932919004286 active site 932919004287 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 932919004288 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 932919004289 active site 932919004290 Riboflavin kinase; Region: Flavokinase; smart00904 932919004291 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 932919004292 16S/18S rRNA binding site [nucleotide binding]; other site 932919004293 S13e-L30e interaction site [polypeptide binding]; other site 932919004294 25S rRNA binding site [nucleotide binding]; other site 932919004295 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 932919004296 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 932919004297 RNase E interface [polypeptide binding]; other site 932919004298 trimer interface [polypeptide binding]; other site 932919004299 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 932919004300 RNase E interface [polypeptide binding]; other site 932919004301 trimer interface [polypeptide binding]; other site 932919004302 active site 932919004303 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 932919004304 putative nucleic acid binding region [nucleotide binding]; other site 932919004305 G-X-X-G motif; other site 932919004306 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 932919004307 RNA binding site [nucleotide binding]; other site 932919004308 domain interface; other site 932919004309 GTPase RsgA; Reviewed; Region: PRK01889 932919004310 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 932919004311 RNA binding site [nucleotide binding]; other site 932919004312 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 932919004313 GTPase/Zn-binding domain interface [polypeptide binding]; other site 932919004314 GTP/Mg2+ binding site [chemical binding]; other site 932919004315 G4 box; other site 932919004316 G5 box; other site 932919004317 G1 box; other site 932919004318 Switch I region; other site 932919004319 G2 box; other site 932919004320 G3 box; other site 932919004321 Switch II region; other site 932919004322 YceG-like family; Region: YceG; pfam02618 932919004323 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 932919004324 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 932919004325 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 932919004326 Rhomboid family; Region: Rhomboid; pfam01694 932919004327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932919004328 TPR motif; other site 932919004329 TPR repeat; Region: TPR_11; pfam13414 932919004330 binding surface 932919004331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 932919004332 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 932919004333 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932919004334 nucleotide binding site [chemical binding]; other site 932919004335 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 932919004336 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 932919004337 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 932919004338 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 932919004339 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 932919004340 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 932919004341 Type II/IV secretion system protein; Region: T2SE; pfam00437 932919004342 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 932919004343 Walker A motif; other site 932919004344 ATP binding site [chemical binding]; other site 932919004345 Walker B motif; other site 932919004346 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 932919004347 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 932919004348 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 932919004349 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 932919004350 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 932919004351 tetramer interface [polypeptide binding]; other site 932919004352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919004353 catalytic residue [active] 932919004354 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 932919004355 tetramer interface [polypeptide binding]; other site 932919004356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919004357 catalytic residue [active] 932919004358 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 932919004359 active site residue [active] 932919004360 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 932919004361 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 932919004362 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 932919004363 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 932919004364 active site 932919004365 elongation factor P; Validated; Region: PRK00529 932919004366 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 932919004367 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 932919004368 RNA binding site [nucleotide binding]; other site 932919004369 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 932919004370 RNA binding site [nucleotide binding]; other site 932919004371 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 932919004372 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 932919004373 carboxyltransferase (CT) interaction site; other site 932919004374 biotinylation site [posttranslational modification]; other site 932919004375 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 932919004376 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 932919004377 ATP-grasp domain; Region: ATP-grasp_4; cl17255 932919004378 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 932919004379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 932919004380 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 932919004381 putative RNA binding site [nucleotide binding]; other site 932919004382 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 932919004383 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 932919004384 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 932919004385 homodimer interface [polypeptide binding]; other site 932919004386 NADP binding site [chemical binding]; other site 932919004387 substrate binding site [chemical binding]; other site 932919004388 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 932919004389 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 932919004390 generic binding surface II; other site 932919004391 generic binding surface I; other site 932919004392 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 932919004393 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 932919004394 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 932919004395 substrate binding pocket [chemical binding]; other site 932919004396 chain length determination region; other site 932919004397 substrate-Mg2+ binding site; other site 932919004398 catalytic residues [active] 932919004399 aspartate-rich region 1; other site 932919004400 active site lid residues [active] 932919004401 aspartate-rich region 2; other site 932919004402 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 932919004403 DNA-binding site [nucleotide binding]; DNA binding site 932919004404 RNA-binding motif; other site 932919004405 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 932919004406 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 932919004407 TPP-binding site; other site 932919004408 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 932919004409 PYR/PP interface [polypeptide binding]; other site 932919004410 dimer interface [polypeptide binding]; other site 932919004411 TPP binding site [chemical binding]; other site 932919004412 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932919004413 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 932919004414 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932919004415 RNA binding surface [nucleotide binding]; other site 932919004416 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 932919004417 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 932919004418 arginine repressor; Provisional; Region: PRK04280 932919004419 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 932919004420 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 932919004421 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 932919004422 Walker A/P-loop; other site 932919004423 ATP binding site [chemical binding]; other site 932919004424 Q-loop/lid; other site 932919004425 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 932919004426 ABC transporter signature motif; other site 932919004427 Walker B; other site 932919004428 D-loop; other site 932919004429 H-loop/switch region; other site 932919004430 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 932919004431 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932919004432 nucleotide binding site [chemical binding]; other site 932919004433 Acetokinase family; Region: Acetate_kinase; cl17229 932919004434 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 932919004435 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932919004436 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 932919004437 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 932919004438 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 932919004439 tetramer interface [polypeptide binding]; other site 932919004440 TPP-binding site [chemical binding]; other site 932919004441 heterodimer interface [polypeptide binding]; other site 932919004442 phosphorylation loop region [posttranslational modification] 932919004443 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 932919004444 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 932919004445 alpha subunit interface [polypeptide binding]; other site 932919004446 TPP binding site [chemical binding]; other site 932919004447 heterodimer interface [polypeptide binding]; other site 932919004448 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932919004449 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 932919004450 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 932919004451 E3 interaction surface; other site 932919004452 lipoyl attachment site [posttranslational modification]; other site 932919004453 e3 binding domain; Region: E3_binding; pfam02817 932919004454 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 932919004455 peptidase T-like protein; Region: PepT-like; TIGR01883 932919004456 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 932919004457 metal binding site [ion binding]; metal-binding site 932919004458 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 932919004459 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 932919004460 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 932919004461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932919004462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919004463 active site 932919004464 phosphorylation site [posttranslational modification] 932919004465 intermolecular recognition site; other site 932919004466 dimerization interface [polypeptide binding]; other site 932919004467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932919004468 DNA binding site [nucleotide binding] 932919004469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 932919004470 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932919004471 dimerization interface [polypeptide binding]; other site 932919004472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932919004473 dimer interface [polypeptide binding]; other site 932919004474 phosphorylation site [posttranslational modification] 932919004475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919004476 ATP binding site [chemical binding]; other site 932919004477 Mg2+ binding site [ion binding]; other site 932919004478 G-X-G motif; other site 932919004479 OxaA-like protein precursor; Validated; Region: PRK01622 932919004480 acylphosphatase; Provisional; Region: PRK14443 932919004481 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 932919004482 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 932919004483 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 932919004484 homotetramer interface [polypeptide binding]; other site 932919004485 FMN binding site [chemical binding]; other site 932919004486 homodimer contacts [polypeptide binding]; other site 932919004487 putative active site [active] 932919004488 putative substrate binding site [chemical binding]; other site 932919004489 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 932919004490 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 932919004491 active site residue [active] 932919004492 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 932919004493 Uncharacterized conserved protein [Function unknown]; Region: COG1284 932919004494 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 932919004495 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 932919004496 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 932919004497 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 932919004498 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 932919004499 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 932919004500 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 932919004501 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 932919004502 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 932919004503 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 932919004504 ligand binding site [chemical binding]; other site 932919004505 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 932919004506 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932919004507 Walker A/P-loop; other site 932919004508 ATP binding site [chemical binding]; other site 932919004509 Q-loop/lid; other site 932919004510 ABC transporter signature motif; other site 932919004511 Walker B; other site 932919004512 D-loop; other site 932919004513 H-loop/switch region; other site 932919004514 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 932919004515 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932919004516 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 932919004517 TM-ABC transporter signature motif; other site 932919004518 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932919004519 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 932919004520 TM-ABC transporter signature motif; other site 932919004521 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 932919004522 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 932919004523 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 932919004524 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 932919004525 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 932919004526 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 932919004527 classical (c) SDRs; Region: SDR_c; cd05233 932919004528 NAD(P) binding site [chemical binding]; other site 932919004529 active site 932919004530 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 932919004531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919004532 non-specific DNA binding site [nucleotide binding]; other site 932919004533 salt bridge; other site 932919004534 sequence-specific DNA binding site [nucleotide binding]; other site 932919004535 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 932919004536 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 932919004537 competence damage-inducible protein A; Provisional; Region: PRK00549 932919004538 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 932919004539 putative MPT binding site; other site 932919004540 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 932919004541 recombinase A; Provisional; Region: recA; PRK09354 932919004542 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 932919004543 hexamer interface [polypeptide binding]; other site 932919004544 Walker A motif; other site 932919004545 ATP binding site [chemical binding]; other site 932919004546 Walker B motif; other site 932919004547 phosphodiesterase; Provisional; Region: PRK12704 932919004548 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932919004549 Zn2+ binding site [ion binding]; other site 932919004550 Mg2+ binding site [ion binding]; other site 932919004551 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 932919004552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919004553 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 932919004554 Coenzyme A binding pocket [chemical binding]; other site 932919004555 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 932919004556 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 932919004557 putative active site [active] 932919004558 metal binding site [ion binding]; metal-binding site 932919004559 homodimer binding site [polypeptide binding]; other site 932919004560 Predicted membrane protein [Function unknown]; Region: COG4550 932919004561 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 932919004562 MutS domain I; Region: MutS_I; pfam01624 932919004563 MutS domain II; Region: MutS_II; pfam05188 932919004564 MutS domain III; Region: MutS_III; pfam05192 932919004565 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 932919004566 Walker A/P-loop; other site 932919004567 ATP binding site [chemical binding]; other site 932919004568 Q-loop/lid; other site 932919004569 ABC transporter signature motif; other site 932919004570 Walker B; other site 932919004571 D-loop; other site 932919004572 H-loop/switch region; other site 932919004573 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 932919004574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919004575 ATP binding site [chemical binding]; other site 932919004576 Mg2+ binding site [ion binding]; other site 932919004577 G-X-G motif; other site 932919004578 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 932919004579 ATP binding site [chemical binding]; other site 932919004580 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 932919004581 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 932919004582 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 932919004583 Pyruvate formate lyase 1; Region: PFL1; cd01678 932919004584 coenzyme A binding site [chemical binding]; other site 932919004585 active site 932919004586 catalytic residues [active] 932919004587 glycine loop; other site 932919004588 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 932919004589 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932919004590 FeS/SAM binding site; other site 932919004591 Predicted transcriptional regulators [Transcription]; Region: COG1695 932919004592 Transcriptional regulator PadR-like family; Region: PadR; cl17335 932919004593 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 932919004594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919004595 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932919004596 putative substrate translocation pore; other site 932919004597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919004598 non-specific DNA binding site [nucleotide binding]; other site 932919004599 salt bridge; other site 932919004600 sequence-specific DNA binding site [nucleotide binding]; other site 932919004601 hypothetical protein; Provisional; Region: PRK06547 932919004602 topology modulation protein; Reviewed; Region: PRK08118 932919004603 AAA domain; Region: AAA_17; pfam13207 932919004604 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919004605 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919004606 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919004607 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919004608 putative acyltransferase; Provisional; Region: PRK05790 932919004609 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 932919004610 dimer interface [polypeptide binding]; other site 932919004611 active site 932919004612 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 932919004613 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 932919004614 dimer interface [polypeptide binding]; other site 932919004615 active site 932919004616 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 932919004617 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 932919004618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919004619 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 932919004620 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 932919004621 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 932919004622 Domain of unknown function DUF20; Region: UPF0118; pfam01594 932919004623 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 932919004624 FAD binding domain; Region: FAD_binding_4; pfam01565 932919004625 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 932919004626 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 932919004627 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 932919004628 Walker A/P-loop; other site 932919004629 ATP binding site [chemical binding]; other site 932919004630 Q-loop/lid; other site 932919004631 ABC transporter signature motif; other site 932919004632 Walker B; other site 932919004633 D-loop; other site 932919004634 H-loop/switch region; other site 932919004635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919004636 dimer interface [polypeptide binding]; other site 932919004637 conserved gate region; other site 932919004638 ABC-ATPase subunit interface; other site 932919004639 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 932919004640 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 932919004641 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 932919004642 manganese transport protein MntH; Reviewed; Region: PRK00701 932919004643 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 932919004644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919004645 dimer interface [polypeptide binding]; other site 932919004646 conserved gate region; other site 932919004647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 932919004648 ABC-ATPase subunit interface; other site 932919004649 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 932919004650 LysR substrate binding domain; Region: LysR_substrate; pfam03466 932919004651 dimerization interface [polypeptide binding]; other site 932919004652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919004653 dimer interface [polypeptide binding]; other site 932919004654 conserved gate region; other site 932919004655 putative PBP binding loops; other site 932919004656 ABC-ATPase subunit interface; other site 932919004657 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 932919004658 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 932919004659 Walker A/P-loop; other site 932919004660 ATP binding site [chemical binding]; other site 932919004661 Q-loop/lid; other site 932919004662 ABC transporter signature motif; other site 932919004663 Walker B; other site 932919004664 D-loop; other site 932919004665 H-loop/switch region; other site 932919004666 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 932919004667 Predicted membrane protein [Function unknown]; Region: COG3859 932919004668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 932919004669 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 932919004670 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932919004671 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932919004672 ABC transporter; Region: ABC_tran_2; pfam12848 932919004673 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932919004674 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 932919004675 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932919004676 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932919004677 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 932919004678 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 932919004679 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932919004680 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 932919004681 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 932919004682 dihydrodipicolinate synthase; Region: dapA; TIGR00674 932919004683 dimer interface [polypeptide binding]; other site 932919004684 active site 932919004685 catalytic residue [active] 932919004686 aspartate kinase I; Reviewed; Region: PRK08210 932919004687 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 932919004688 nucleotide binding site [chemical binding]; other site 932919004689 substrate binding site [chemical binding]; other site 932919004690 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 932919004691 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 932919004692 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 932919004693 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 932919004694 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 932919004695 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 932919004696 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 932919004697 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 932919004698 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 932919004699 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 932919004700 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 932919004701 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 932919004702 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 932919004703 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 932919004704 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 932919004705 Predicted membrane protein [Function unknown]; Region: COG4392 932919004706 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 932919004707 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 932919004708 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 932919004709 metal binding site 2 [ion binding]; metal-binding site 932919004710 putative DNA binding helix; other site 932919004711 metal binding site 1 [ion binding]; metal-binding site 932919004712 dimer interface [polypeptide binding]; other site 932919004713 structural Zn2+ binding site [ion binding]; other site 932919004714 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 932919004715 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932919004716 ABC-ATPase subunit interface; other site 932919004717 dimer interface [polypeptide binding]; other site 932919004718 putative PBP binding regions; other site 932919004719 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 932919004720 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 932919004721 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 932919004722 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 932919004723 DHHA2 domain; Region: DHHA2; pfam02833 932919004724 endonuclease IV; Provisional; Region: PRK01060 932919004725 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 932919004726 AP (apurinic/apyrimidinic) site pocket; other site 932919004727 DNA interaction; other site 932919004728 Metal-binding active site; metal-binding site 932919004729 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 932919004730 DEAD-like helicases superfamily; Region: DEXDc; smart00487 932919004731 ATP binding site [chemical binding]; other site 932919004732 Mg++ binding site [ion binding]; other site 932919004733 motif III; other site 932919004734 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932919004735 nucleotide binding region [chemical binding]; other site 932919004736 ATP-binding site [chemical binding]; other site 932919004737 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 932919004738 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 932919004739 Uncharacterized conserved protein [Function unknown]; Region: COG0327 932919004740 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 932919004741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 932919004742 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 932919004743 Uncharacterized conserved protein [Function unknown]; Region: COG0327 932919004744 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 932919004745 Family of unknown function (DUF633); Region: DUF633; pfam04816 932919004746 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 932919004747 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 932919004748 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 932919004749 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932919004750 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 932919004751 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 932919004752 DNA binding residues [nucleotide binding] 932919004753 DNA primase; Validated; Region: dnaG; PRK05667 932919004754 CHC2 zinc finger; Region: zf-CHC2; pfam01807 932919004755 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 932919004756 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 932919004757 active site 932919004758 metal binding site [ion binding]; metal-binding site 932919004759 interdomain interaction site; other site 932919004760 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 932919004761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 932919004762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 932919004763 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 932919004764 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 932919004765 DALR anticodon binding domain; Region: DALR_1; pfam05746 932919004766 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 932919004767 dimer interface [polypeptide binding]; other site 932919004768 motif 1; other site 932919004769 active site 932919004770 motif 2; other site 932919004771 motif 3; other site 932919004772 DNA repair protein RecO; Region: reco; TIGR00613 932919004773 Recombination protein O N terminal; Region: RecO_N; pfam11967 932919004774 Recombination protein O C terminal; Region: RecO_C; pfam02565 932919004775 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 932919004776 GTPase Era; Reviewed; Region: era; PRK00089 932919004777 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 932919004778 G1 box; other site 932919004779 GTP/Mg2+ binding site [chemical binding]; other site 932919004780 Switch I region; other site 932919004781 G2 box; other site 932919004782 Switch II region; other site 932919004783 G3 box; other site 932919004784 G4 box; other site 932919004785 G5 box; other site 932919004786 KH domain; Region: KH_2; pfam07650 932919004787 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 932919004788 active site 932919004789 catalytic motif [active] 932919004790 Zn binding site [ion binding]; other site 932919004791 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 932919004792 metal-binding heat shock protein; Provisional; Region: PRK00016 932919004793 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 932919004794 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 932919004795 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932919004796 Zn2+ binding site [ion binding]; other site 932919004797 Mg2+ binding site [ion binding]; other site 932919004798 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 932919004799 PhoH-like protein; Region: PhoH; pfam02562 932919004800 Yqey-like protein; Region: YqeY; pfam09424 932919004801 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 932919004802 RNA methyltransferase, RsmE family; Region: TIGR00046 932919004803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 932919004804 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 932919004805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919004806 S-adenosylmethionine binding site [chemical binding]; other site 932919004807 chaperone protein DnaJ; Provisional; Region: PRK14280 932919004808 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 932919004809 HSP70 interaction site [polypeptide binding]; other site 932919004810 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 932919004811 substrate binding site [polypeptide binding]; other site 932919004812 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 932919004813 Zn binding sites [ion binding]; other site 932919004814 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 932919004815 dimer interface [polypeptide binding]; other site 932919004816 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 932919004817 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 932919004818 nucleotide binding site [chemical binding]; other site 932919004819 NEF interaction site [polypeptide binding]; other site 932919004820 SBD interface [polypeptide binding]; other site 932919004821 heat shock protein GrpE; Provisional; Region: PRK14140 932919004822 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 932919004823 dimer interface [polypeptide binding]; other site 932919004824 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 932919004825 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 932919004826 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 932919004827 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 932919004828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932919004829 FeS/SAM binding site; other site 932919004830 HemN C-terminal domain; Region: HemN_C; pfam06969 932919004831 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 932919004832 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 932919004833 NADP binding site [chemical binding]; other site 932919004834 putative substrate binding site [chemical binding]; other site 932919004835 active site 932919004836 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 932919004837 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 932919004838 DNA binding residues [nucleotide binding] 932919004839 putative dimer interface [polypeptide binding]; other site 932919004840 GTP-binding protein LepA; Provisional; Region: PRK05433 932919004841 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 932919004842 G1 box; other site 932919004843 putative GEF interaction site [polypeptide binding]; other site 932919004844 GTP/Mg2+ binding site [chemical binding]; other site 932919004845 Switch I region; other site 932919004846 G2 box; other site 932919004847 G3 box; other site 932919004848 Switch II region; other site 932919004849 G4 box; other site 932919004850 G5 box; other site 932919004851 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 932919004852 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 932919004853 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 932919004854 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 932919004855 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 932919004856 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 932919004857 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 932919004858 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 932919004859 Competence protein; Region: Competence; pfam03772 932919004860 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932919004861 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 932919004862 catalytic motif [active] 932919004863 Zn binding site [ion binding]; other site 932919004864 SLBB domain; Region: SLBB; pfam10531 932919004865 comEA protein; Region: comE; TIGR01259 932919004866 Helix-hairpin-helix motif; Region: HHH; pfam00633 932919004867 Methyltransferase domain; Region: Methyltransf_23; pfam13489 932919004868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919004869 S-adenosylmethionine binding site [chemical binding]; other site 932919004870 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 932919004871 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 932919004872 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 932919004873 Zn2+ binding site [ion binding]; other site 932919004874 Mg2+ binding site [ion binding]; other site 932919004875 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 932919004876 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 932919004877 active site 932919004878 (T/H)XGH motif; other site 932919004879 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 932919004880 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 932919004881 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 932919004882 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 932919004883 shikimate binding site; other site 932919004884 NAD(P) binding site [chemical binding]; other site 932919004885 GTPase YqeH; Provisional; Region: PRK13796 932919004886 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 932919004887 GTP/Mg2+ binding site [chemical binding]; other site 932919004888 G4 box; other site 932919004889 G5 box; other site 932919004890 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 932919004891 G1 box; other site 932919004892 G1 box; other site 932919004893 GTP/Mg2+ binding site [chemical binding]; other site 932919004894 G2 box; other site 932919004895 Switch I region; other site 932919004896 G2 box; other site 932919004897 Switch I region; other site 932919004898 G3 box; other site 932919004899 G3 box; other site 932919004900 Switch II region; other site 932919004901 Switch II region; other site 932919004902 G4 box; other site 932919004903 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 932919004904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919004905 motif II; other site 932919004906 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 932919004907 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 932919004908 active site 932919004909 Zn binding site [ion binding]; other site 932919004910 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 932919004911 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 932919004912 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 932919004913 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 932919004914 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 932919004915 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 932919004916 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 932919004917 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 932919004918 Sugar specificity; other site 932919004919 Pyrimidine base specificity; other site 932919004920 ATP-binding site [chemical binding]; other site 932919004921 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 932919004922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919004923 S-adenosylmethionine binding site [chemical binding]; other site 932919004924 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 932919004925 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 932919004926 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 932919004927 dimerization interface [polypeptide binding]; other site 932919004928 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 932919004929 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 932919004930 hypothetical protein; Provisional; Region: PRK13678 932919004931 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 932919004932 hypothetical protein; Provisional; Region: PRK05473 932919004933 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 932919004934 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 932919004935 motif 1; other site 932919004936 active site 932919004937 motif 2; other site 932919004938 motif 3; other site 932919004939 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 932919004940 DHHA1 domain; Region: DHHA1; pfam02272 932919004941 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932919004942 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932919004943 Walker A/P-loop; other site 932919004944 ATP binding site [chemical binding]; other site 932919004945 Q-loop/lid; other site 932919004946 ABC transporter signature motif; other site 932919004947 Walker B; other site 932919004948 D-loop; other site 932919004949 H-loop/switch region; other site 932919004950 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932919004951 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 932919004952 FtsX-like permease family; Region: FtsX; pfam02687 932919004953 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932919004954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919004955 active site 932919004956 phosphorylation site [posttranslational modification] 932919004957 intermolecular recognition site; other site 932919004958 dimerization interface [polypeptide binding]; other site 932919004959 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932919004960 DNA binding site [nucleotide binding] 932919004961 sensor kinase CusS; Provisional; Region: PRK09835 932919004962 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932919004963 dimerization interface [polypeptide binding]; other site 932919004964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932919004965 dimer interface [polypeptide binding]; other site 932919004966 phosphorylation site [posttranslational modification] 932919004967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919004968 ATP binding site [chemical binding]; other site 932919004969 Mg2+ binding site [ion binding]; other site 932919004970 G-X-G motif; other site 932919004971 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 932919004972 AAA domain; Region: AAA_30; pfam13604 932919004973 Family description; Region: UvrD_C_2; pfam13538 932919004974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932919004975 binding surface 932919004976 TPR motif; other site 932919004977 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 932919004978 TPR repeat; Region: TPR_11; pfam13414 932919004979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932919004980 binding surface 932919004981 TPR motif; other site 932919004982 TPR repeat; Region: TPR_11; pfam13414 932919004983 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 932919004984 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 932919004985 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 932919004986 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 932919004987 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 932919004988 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932919004989 catalytic residue [active] 932919004990 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 932919004991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919004992 Walker A motif; other site 932919004993 ATP binding site [chemical binding]; other site 932919004994 Walker B motif; other site 932919004995 arginine finger; other site 932919004996 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 932919004997 Predicted transcriptional regulator [Transcription]; Region: COG1959 932919004998 Transcriptional regulator; Region: Rrf2; pfam02082 932919004999 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 932919005000 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 932919005001 Nitrogen regulatory protein P-II; Region: P-II; smart00938 932919005002 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 932919005003 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 932919005004 dimer interface [polypeptide binding]; other site 932919005005 anticodon binding site; other site 932919005006 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 932919005007 homodimer interface [polypeptide binding]; other site 932919005008 motif 1; other site 932919005009 active site 932919005010 motif 2; other site 932919005011 GAD domain; Region: GAD; pfam02938 932919005012 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 932919005013 motif 3; other site 932919005014 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 932919005015 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 932919005016 dimer interface [polypeptide binding]; other site 932919005017 motif 1; other site 932919005018 active site 932919005019 motif 2; other site 932919005020 motif 3; other site 932919005021 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 932919005022 anticodon binding site; other site 932919005023 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 932919005024 Bacterial SH3 domain; Region: SH3_3; pfam08239 932919005025 Bacterial SH3 domain; Region: SH3_3; pfam08239 932919005026 Bacterial SH3 domain homologues; Region: SH3b; smart00287 932919005027 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 932919005028 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 932919005029 active site 932919005030 metal binding site [ion binding]; metal-binding site 932919005031 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 932919005032 putative active site [active] 932919005033 dimerization interface [polypeptide binding]; other site 932919005034 putative tRNAtyr binding site [nucleotide binding]; other site 932919005035 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 932919005036 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932919005037 Zn2+ binding site [ion binding]; other site 932919005038 Mg2+ binding site [ion binding]; other site 932919005039 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 932919005040 synthetase active site [active] 932919005041 NTP binding site [chemical binding]; other site 932919005042 metal binding site [ion binding]; metal-binding site 932919005043 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 932919005044 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 932919005045 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932919005046 active site 932919005047 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 932919005048 DHH family; Region: DHH; pfam01368 932919005049 DHHA1 domain; Region: DHHA1; pfam02272 932919005050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 932919005051 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 932919005052 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 932919005053 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 932919005054 Protein export membrane protein; Region: SecD_SecF; cl14618 932919005055 Protein export membrane protein; Region: SecD_SecF; pfam02355 932919005056 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 932919005057 Preprotein translocase subunit; Region: YajC; pfam02699 932919005058 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 932919005059 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 932919005060 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 932919005061 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 932919005062 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 932919005063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919005064 Walker A motif; other site 932919005065 ATP binding site [chemical binding]; other site 932919005066 Walker B motif; other site 932919005067 arginine finger; other site 932919005068 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 932919005069 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 932919005070 RuvA N terminal domain; Region: RuvA_N; pfam01330 932919005071 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 932919005072 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 932919005073 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932919005074 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 932919005075 NAD binding site [chemical binding]; other site 932919005076 dimer interface [polypeptide binding]; other site 932919005077 substrate binding site [chemical binding]; other site 932919005078 hypothetical protein; Validated; Region: PRK00110 932919005079 prephenate dehydratase; Provisional; Region: PRK11898 932919005080 Prephenate dehydratase; Region: PDT; pfam00800 932919005081 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 932919005082 putative L-Phe binding site [chemical binding]; other site 932919005083 GTPase CgtA; Reviewed; Region: obgE; PRK12297 932919005084 GTP1/OBG; Region: GTP1_OBG; pfam01018 932919005085 Obg GTPase; Region: Obg; cd01898 932919005086 G1 box; other site 932919005087 GTP/Mg2+ binding site [chemical binding]; other site 932919005088 Switch I region; other site 932919005089 G2 box; other site 932919005090 G3 box; other site 932919005091 Switch II region; other site 932919005092 G4 box; other site 932919005093 G5 box; other site 932919005094 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 932919005095 glycerol kinase; Provisional; Region: glpK; PRK00047 932919005096 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 932919005097 N- and C-terminal domain interface [polypeptide binding]; other site 932919005098 active site 932919005099 MgATP binding site [chemical binding]; other site 932919005100 catalytic site [active] 932919005101 metal binding site [ion binding]; metal-binding site 932919005102 glycerol binding site [chemical binding]; other site 932919005103 homotetramer interface [polypeptide binding]; other site 932919005104 homodimer interface [polypeptide binding]; other site 932919005105 FBP binding site [chemical binding]; other site 932919005106 protein IIAGlc interface [polypeptide binding]; other site 932919005107 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 932919005108 amphipathic channel; other site 932919005109 Asn-Pro-Ala signature motifs; other site 932919005110 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 932919005111 hypothetical protein; Provisional; Region: PRK14553 932919005112 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 932919005113 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 932919005114 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 932919005115 homodimer interface [polypeptide binding]; other site 932919005116 oligonucleotide binding site [chemical binding]; other site 932919005117 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 932919005118 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 932919005119 Switch I; other site 932919005120 Switch II; other site 932919005121 septum formation inhibitor; Reviewed; Region: minC; PRK00513 932919005122 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 932919005123 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 932919005124 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 932919005125 Protein of unknown function (DUF972); Region: DUF972; pfam06156 932919005126 rod shape-determining protein MreC; Region: MreC; pfam04085 932919005127 rod shape-determining protein MreB; Provisional; Region: PRK13927 932919005128 MreB and similar proteins; Region: MreB_like; cd10225 932919005129 nucleotide binding site [chemical binding]; other site 932919005130 Mg binding site [ion binding]; other site 932919005131 putative protofilament interaction site [polypeptide binding]; other site 932919005132 RodZ interaction site [polypeptide binding]; other site 932919005133 hypothetical protein; Reviewed; Region: PRK00024 932919005134 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 932919005135 MPN+ (JAMM) motif; other site 932919005136 Zinc-binding site [ion binding]; other site 932919005137 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 932919005138 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 932919005139 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 932919005140 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932919005141 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 932919005142 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 932919005143 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 932919005144 active site 932919005145 HIGH motif; other site 932919005146 nucleotide binding site [chemical binding]; other site 932919005147 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 932919005148 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 932919005149 active site 932919005150 KMSKS motif; other site 932919005151 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 932919005152 tRNA binding surface [nucleotide binding]; other site 932919005153 anticodon binding site; other site 932919005154 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 932919005155 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 932919005156 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 932919005157 inhibitor-cofactor binding pocket; inhibition site 932919005158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919005159 catalytic residue [active] 932919005160 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 932919005161 dimer interface [polypeptide binding]; other site 932919005162 active site 932919005163 Schiff base residues; other site 932919005164 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 932919005165 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 932919005166 active site 932919005167 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 932919005168 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 932919005169 domain interfaces; other site 932919005170 active site 932919005171 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 932919005172 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 932919005173 tRNA; other site 932919005174 putative tRNA binding site [nucleotide binding]; other site 932919005175 putative NADP binding site [chemical binding]; other site 932919005176 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 932919005177 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 932919005178 G1 box; other site 932919005179 GTP/Mg2+ binding site [chemical binding]; other site 932919005180 Switch I region; other site 932919005181 G2 box; other site 932919005182 G3 box; other site 932919005183 Switch II region; other site 932919005184 G4 box; other site 932919005185 G5 box; other site 932919005186 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 932919005187 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 932919005188 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 932919005189 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 932919005190 active site 932919005191 dimer interface [polypeptide binding]; other site 932919005192 motif 1; other site 932919005193 motif 2; other site 932919005194 motif 3; other site 932919005195 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 932919005196 anticodon binding site; other site 932919005197 primosomal protein DnaI; Reviewed; Region: PRK08939 932919005198 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 932919005199 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 932919005200 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 932919005201 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 932919005202 ATP cone domain; Region: ATP-cone; pfam03477 932919005203 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 932919005204 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 932919005205 CoA-binding site [chemical binding]; other site 932919005206 ATP-binding [chemical binding]; other site 932919005207 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 932919005208 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 932919005209 DNA binding site [nucleotide binding] 932919005210 catalytic residue [active] 932919005211 H2TH interface [polypeptide binding]; other site 932919005212 putative catalytic residues [active] 932919005213 turnover-facilitating residue; other site 932919005214 intercalation triad [nucleotide binding]; other site 932919005215 8OG recognition residue [nucleotide binding]; other site 932919005216 putative reading head residues; other site 932919005217 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 932919005218 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 932919005219 DNA polymerase I; Provisional; Region: PRK05755 932919005220 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 932919005221 active site 932919005222 metal binding site 1 [ion binding]; metal-binding site 932919005223 putative 5' ssDNA interaction site; other site 932919005224 metal binding site 3; metal-binding site 932919005225 metal binding site 2 [ion binding]; metal-binding site 932919005226 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 932919005227 putative DNA binding site [nucleotide binding]; other site 932919005228 putative metal binding site [ion binding]; other site 932919005229 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 932919005230 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 932919005231 active site 932919005232 DNA binding site [nucleotide binding] 932919005233 catalytic site [active] 932919005234 isocitrate dehydrogenase; Reviewed; Region: PRK07006 932919005235 isocitrate dehydrogenase; Validated; Region: PRK07362 932919005236 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 932919005237 dimer interface [polypeptide binding]; other site 932919005238 Citrate synthase; Region: Citrate_synt; pfam00285 932919005239 active site 932919005240 citrylCoA binding site [chemical binding]; other site 932919005241 oxalacetate/citrate binding site [chemical binding]; other site 932919005242 coenzyme A binding site [chemical binding]; other site 932919005243 catalytic triad [active] 932919005244 Protein of unknown function (DUF441); Region: DUF441; pfam04284 932919005245 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 932919005246 pyruvate kinase; Provisional; Region: PRK06354 932919005247 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 932919005248 domain interfaces; other site 932919005249 active site 932919005250 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 932919005251 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 932919005252 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 932919005253 active site 932919005254 ADP/pyrophosphate binding site [chemical binding]; other site 932919005255 dimerization interface [polypeptide binding]; other site 932919005256 allosteric effector site; other site 932919005257 fructose-1,6-bisphosphate binding site; other site 932919005258 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 932919005259 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 932919005260 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 932919005261 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 932919005262 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 932919005263 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 932919005264 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 932919005265 active site 932919005266 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 932919005267 generic binding surface I; other site 932919005268 generic binding surface II; other site 932919005269 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 932919005270 DHH family; Region: DHH; pfam01368 932919005271 DHHA1 domain; Region: DHHA1; pfam02272 932919005272 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 932919005273 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 932919005274 DNA-binding site [nucleotide binding]; DNA binding site 932919005275 DRTGG domain; Region: DRTGG; pfam07085 932919005276 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 932919005277 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 932919005278 active site 2 [active] 932919005279 active site 1 [active] 932919005280 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 932919005281 metal-dependent hydrolase; Provisional; Region: PRK00685 932919005282 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 932919005283 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 932919005284 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 932919005285 active site 932919005286 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 932919005287 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 932919005288 hexamer interface [polypeptide binding]; other site 932919005289 ligand binding site [chemical binding]; other site 932919005290 putative active site [active] 932919005291 NAD(P) binding site [chemical binding]; other site 932919005292 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 932919005293 Ligand Binding Site [chemical binding]; other site 932919005294 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 932919005295 propionate/acetate kinase; Provisional; Region: PRK12379 932919005296 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 932919005297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919005298 S-adenosylmethionine binding site [chemical binding]; other site 932919005299 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 932919005300 dimer interface [polypeptide binding]; other site 932919005301 catalytic triad [active] 932919005302 peroxidatic and resolving cysteines [active] 932919005303 RDD family; Region: RDD; pfam06271 932919005304 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 932919005305 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 932919005306 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 932919005307 tandem repeat interface [polypeptide binding]; other site 932919005308 active site residues [active] 932919005309 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 932919005310 ATP-NAD kinase; Region: NAD_kinase; pfam01513 932919005311 ornithine carbamoyltransferase; Provisional; Region: PRK00779 932919005312 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 932919005313 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 932919005314 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 932919005315 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 932919005316 inhibitor-cofactor binding pocket; inhibition site 932919005317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919005318 catalytic residue [active] 932919005319 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 932919005320 nucleotide binding site [chemical binding]; other site 932919005321 N-acetyl-L-glutamate binding site [chemical binding]; other site 932919005322 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 932919005323 heterotetramer interface [polypeptide binding]; other site 932919005324 active site pocket [active] 932919005325 cleavage site 932919005326 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 932919005327 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 932919005328 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 932919005329 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 932919005330 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 932919005331 Ligand Binding Site [chemical binding]; other site 932919005332 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 932919005333 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 932919005334 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932919005335 catalytic residue [active] 932919005336 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 932919005337 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 932919005338 GAF domain; Region: GAF_2; pfam13185 932919005339 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 932919005340 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 932919005341 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932919005342 RNA binding surface [nucleotide binding]; other site 932919005343 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 932919005344 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 932919005345 active site 932919005346 HIGH motif; other site 932919005347 dimer interface [polypeptide binding]; other site 932919005348 KMSKS motif; other site 932919005349 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932919005350 RNA binding surface [nucleotide binding]; other site 932919005351 catabolite control protein A; Region: ccpA; TIGR01481 932919005352 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932919005353 DNA binding site [nucleotide binding] 932919005354 domain linker motif; other site 932919005355 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 932919005356 dimerization interface [polypeptide binding]; other site 932919005357 effector binding site; other site 932919005358 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 932919005359 Chorismate mutase type II; Region: CM_2; cl00693 932919005360 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 932919005361 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 932919005362 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 932919005363 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 932919005364 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 932919005365 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 932919005366 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 932919005367 dimer interface [polypeptide binding]; other site 932919005368 decamer (pentamer of dimers) interface [polypeptide binding]; other site 932919005369 catalytic triad [active] 932919005370 peroxidatic and resolving cysteines [active] 932919005371 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 932919005372 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 932919005373 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932919005374 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 932919005375 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 932919005376 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 932919005377 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 932919005378 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 932919005379 putative tRNA-binding site [nucleotide binding]; other site 932919005380 hypothetical protein; Provisional; Region: PRK13668 932919005381 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 932919005382 catalytic residues [active] 932919005383 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 932919005384 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 932919005385 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 932919005386 oligomer interface [polypeptide binding]; other site 932919005387 active site 932919005388 metal binding site [ion binding]; metal-binding site 932919005389 Predicted small secreted protein [Function unknown]; Region: COG5584 932919005390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 932919005391 putative homodimer interface [polypeptide binding]; other site 932919005392 putative homotetramer interface [polypeptide binding]; other site 932919005393 putative allosteric switch controlling residues; other site 932919005394 putative metal binding site [ion binding]; other site 932919005395 putative homodimer-homodimer interface [polypeptide binding]; other site 932919005396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932919005397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919005398 S-adenosylmethionine binding site [chemical binding]; other site 932919005399 Phosphotransferase enzyme family; Region: APH; pfam01636 932919005400 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 932919005401 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 932919005402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919005403 putative substrate translocation pore; other site 932919005404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919005405 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932919005406 MarR family; Region: MarR; pfam01047 932919005407 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 932919005408 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 932919005409 homodimer interface [polypeptide binding]; other site 932919005410 substrate-cofactor binding pocket; other site 932919005411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919005412 catalytic residue [active] 932919005413 dipeptidase PepV; Reviewed; Region: PRK07318 932919005414 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 932919005415 active site 932919005416 metal binding site [ion binding]; metal-binding site 932919005417 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 932919005418 nudix motif; other site 932919005419 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 932919005420 putative substrate binding site [chemical binding]; other site 932919005421 putative ATP binding site [chemical binding]; other site 932919005422 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 932919005423 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 932919005424 active site 932919005425 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 932919005426 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 932919005427 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 932919005428 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 932919005429 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 932919005430 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 932919005431 substrate binding site [chemical binding]; other site 932919005432 active site 932919005433 catalytic residues [active] 932919005434 heterodimer interface [polypeptide binding]; other site 932919005435 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 932919005436 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 932919005437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919005438 catalytic residue [active] 932919005439 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 932919005440 active site 932919005441 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 932919005442 active site 932919005443 ribulose/triose binding site [chemical binding]; other site 932919005444 phosphate binding site [ion binding]; other site 932919005445 substrate (anthranilate) binding pocket [chemical binding]; other site 932919005446 product (indole) binding pocket [chemical binding]; other site 932919005447 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 932919005448 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 932919005449 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 932919005450 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 932919005451 Glutamine amidotransferase class-I; Region: GATase; pfam00117 932919005452 glutamine binding [chemical binding]; other site 932919005453 catalytic triad [active] 932919005454 anthranilate synthase component I; Provisional; Region: PRK13570 932919005455 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 932919005456 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 932919005457 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 932919005458 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 932919005459 putative catalytic cysteine [active] 932919005460 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 932919005461 putative active site [active] 932919005462 metal binding site [ion binding]; metal-binding site 932919005463 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 932919005464 dimer interface [polypeptide binding]; other site 932919005465 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 932919005466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919005467 Walker A/P-loop; other site 932919005468 ATP binding site [chemical binding]; other site 932919005469 Q-loop/lid; other site 932919005470 ABC transporter signature motif; other site 932919005471 Walker B; other site 932919005472 D-loop; other site 932919005473 H-loop/switch region; other site 932919005474 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 932919005475 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 932919005476 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 932919005477 putative dimer interface [polypeptide binding]; other site 932919005478 catalytic triad [active] 932919005479 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 932919005480 aconitate hydratase; Validated; Region: PRK09277 932919005481 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 932919005482 substrate binding site [chemical binding]; other site 932919005483 ligand binding site [chemical binding]; other site 932919005484 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 932919005485 substrate binding site [chemical binding]; other site 932919005486 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 932919005487 Heat induced stress protein YflT; Region: YflT; pfam11181 932919005488 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 932919005489 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 932919005490 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932919005491 ATP binding site [chemical binding]; other site 932919005492 putative Mg++ binding site [ion binding]; other site 932919005493 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932919005494 nucleotide binding region [chemical binding]; other site 932919005495 ATP-binding site [chemical binding]; other site 932919005496 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 932919005497 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 932919005498 Walker A/P-loop; other site 932919005499 ATP binding site [chemical binding]; other site 932919005500 Q-loop/lid; other site 932919005501 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 932919005502 ABC transporter signature motif; other site 932919005503 Walker B; other site 932919005504 D-loop; other site 932919005505 H-loop/switch region; other site 932919005506 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 932919005507 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 932919005508 active site 932919005509 metal binding site [ion binding]; metal-binding site 932919005510 DNA binding site [nucleotide binding] 932919005511 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 932919005512 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 932919005513 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 932919005514 putative acyl-acceptor binding pocket; other site 932919005515 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 932919005516 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932919005517 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932919005518 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 932919005519 Walker A/P-loop; other site 932919005520 ATP binding site [chemical binding]; other site 932919005521 Q-loop/lid; other site 932919005522 ABC transporter signature motif; other site 932919005523 Walker B; other site 932919005524 D-loop; other site 932919005525 H-loop/switch region; other site 932919005526 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932919005527 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 932919005528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919005529 Walker A/P-loop; other site 932919005530 ATP binding site [chemical binding]; other site 932919005531 Q-loop/lid; other site 932919005532 ABC transporter signature motif; other site 932919005533 Walker B; other site 932919005534 D-loop; other site 932919005535 H-loop/switch region; other site 932919005536 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 932919005537 active site 932919005538 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 932919005539 elongation factor Ts; Provisional; Region: tsf; PRK09377 932919005540 UBA/TS-N domain; Region: UBA; pfam00627 932919005541 Elongation factor TS; Region: EF_TS; pfam00889 932919005542 Elongation factor TS; Region: EF_TS; pfam00889 932919005543 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 932919005544 rRNA interaction site [nucleotide binding]; other site 932919005545 S8 interaction site; other site 932919005546 putative laminin-1 binding site; other site 932919005547 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 932919005548 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932919005549 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 932919005550 active site turn [active] 932919005551 phosphorylation site [posttranslational modification] 932919005552 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932919005553 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 932919005554 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 932919005555 putative active site [active] 932919005556 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932919005557 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932919005558 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932919005559 putative active site [active] 932919005560 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 932919005561 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 932919005562 HIGH motif; other site 932919005563 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 932919005564 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 932919005565 active site 932919005566 KMSKS motif; other site 932919005567 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 932919005568 tRNA binding surface [nucleotide binding]; other site 932919005569 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 932919005570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932919005571 FeS/SAM binding site; other site 932919005572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 932919005573 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 932919005574 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 932919005575 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 932919005576 active site 932919005577 dimer interface [polypeptide binding]; other site 932919005578 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 932919005579 Ligand Binding Site [chemical binding]; other site 932919005580 Molecular Tunnel; other site 932919005581 S-adenosylmethionine synthetase; Validated; Region: PRK05250 932919005582 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 932919005583 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 932919005584 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 932919005585 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932919005586 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932919005587 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 932919005588 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932919005589 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 932919005590 NAD binding site [chemical binding]; other site 932919005591 dimer interface [polypeptide binding]; other site 932919005592 substrate binding site [chemical binding]; other site 932919005593 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 932919005594 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 932919005595 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 932919005596 nudix motif; other site 932919005597 Uncharacterized conserved protein [Function unknown]; Region: COG0759 932919005598 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 932919005599 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 932919005600 metal binding site [ion binding]; metal-binding site 932919005601 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 932919005602 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 932919005603 acyl-activating enzyme (AAE) consensus motif; other site 932919005604 putative AMP binding site [chemical binding]; other site 932919005605 putative active site [active] 932919005606 putative CoA binding site [chemical binding]; other site 932919005607 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 932919005608 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 932919005609 substrate binding site [chemical binding]; other site 932919005610 oxyanion hole (OAH) forming residues; other site 932919005611 trimer interface [polypeptide binding]; other site 932919005612 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 932919005613 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 932919005614 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 932919005615 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 932919005616 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 932919005617 dimer interface [polypeptide binding]; other site 932919005618 tetramer interface [polypeptide binding]; other site 932919005619 PYR/PP interface [polypeptide binding]; other site 932919005620 TPP binding site [chemical binding]; other site 932919005621 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 932919005622 TPP-binding site; other site 932919005623 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 932919005624 chorismate binding enzyme; Region: Chorismate_bind; cl10555 932919005625 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 932919005626 UbiA prenyltransferase family; Region: UbiA; pfam01040 932919005627 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 932919005628 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 932919005629 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 932919005630 FAD binding site [chemical binding]; other site 932919005631 cystathionine beta-lyase; Provisional; Region: PRK08064 932919005632 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 932919005633 homodimer interface [polypeptide binding]; other site 932919005634 substrate-cofactor binding pocket; other site 932919005635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919005636 catalytic residue [active] 932919005637 cystathionine gamma-synthase; Reviewed; Region: PRK08247 932919005638 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 932919005639 homodimer interface [polypeptide binding]; other site 932919005640 substrate-cofactor binding pocket; other site 932919005641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919005642 catalytic residue [active] 932919005643 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 932919005644 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 932919005645 THF binding site; other site 932919005646 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 932919005647 substrate binding site [chemical binding]; other site 932919005648 THF binding site; other site 932919005649 zinc-binding site [ion binding]; other site 932919005650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919005651 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932919005652 putative substrate translocation pore; other site 932919005653 ferric uptake regulator; Provisional; Region: fur; PRK09462 932919005654 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 932919005655 metal binding site 2 [ion binding]; metal-binding site 932919005656 putative DNA binding helix; other site 932919005657 metal binding site 1 [ion binding]; metal-binding site 932919005658 dimer interface [polypeptide binding]; other site 932919005659 structural Zn2+ binding site [ion binding]; other site 932919005660 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 932919005661 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 932919005662 NAD binding site [chemical binding]; other site 932919005663 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 932919005664 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 932919005665 inhibitor-cofactor binding pocket; inhibition site 932919005666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919005667 catalytic residue [active] 932919005668 Predicted membrane protein [Function unknown]; Region: COG4129 932919005669 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 932919005670 hypothetical protein; Provisional; Region: PRK13662 932919005671 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 932919005672 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 932919005673 putative NAD(P) binding site [chemical binding]; other site 932919005674 active site 932919005675 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 932919005676 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 932919005677 minor groove reading motif; other site 932919005678 helix-hairpin-helix signature motif; other site 932919005679 substrate binding pocket [chemical binding]; other site 932919005680 active site 932919005681 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 932919005682 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 932919005683 DNA binding and oxoG recognition site [nucleotide binding] 932919005684 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 932919005685 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 932919005686 trimer interface [polypeptide binding]; other site 932919005687 active site 932919005688 WVELL protein; Region: WVELL; pfam14043 932919005689 recombination regulator RecX; Provisional; Region: recX; PRK14135 932919005690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932919005691 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 932919005692 NAD(P) binding site [chemical binding]; other site 932919005693 active site 932919005694 Predicted integral membrane protein [Function unknown]; Region: COG0392 932919005695 Uncharacterized conserved protein [Function unknown]; Region: COG2898 932919005696 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 932919005697 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 932919005698 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 932919005699 Cation efflux family; Region: Cation_efflux; pfam01545 932919005700 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 932919005701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 932919005702 PAS fold; Region: PAS_4; pfam08448 932919005703 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932919005704 putative active site [active] 932919005705 heme pocket [chemical binding]; other site 932919005706 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 932919005707 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932919005708 dimer interface [polypeptide binding]; other site 932919005709 putative CheW interface [polypeptide binding]; other site 932919005710 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 932919005711 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 932919005712 dimer interface [polypeptide binding]; other site 932919005713 active site 932919005714 Mn binding site [ion binding]; other site 932919005715 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 932919005716 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 932919005717 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 932919005718 catalytic residues [active] 932919005719 catalytic nucleophile [active] 932919005720 Recombinase; Region: Recombinase; pfam07508 932919005721 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 932919005722 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 932919005723 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 932919005724 catalytic residues [active] 932919005725 catalytic nucleophile [active] 932919005726 Recombinase; Region: Recombinase; pfam07508 932919005727 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 932919005728 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 932919005729 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 932919005730 amidase catalytic site [active] 932919005731 Zn binding residues [ion binding]; other site 932919005732 substrate binding site [chemical binding]; other site 932919005733 Holin family; Region: Phage_holin_4; pfam05105 932919005734 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 932919005735 Phage-related protein [Function unknown]; Region: COG4722 932919005736 Phage tail protein; Region: Sipho_tail; cl17486 932919005737 Phage-related protein [Function unknown]; Region: COG5412 932919005738 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 932919005739 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 932919005740 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 932919005741 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 932919005742 oligomerization interface [polypeptide binding]; other site 932919005743 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 932919005744 Phage capsid family; Region: Phage_capsid; pfam05065 932919005745 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 932919005746 oligomer interface [polypeptide binding]; other site 932919005747 active site residues [active] 932919005748 Phage-related protein [Function unknown]; Region: COG4695 932919005749 Phage portal protein; Region: Phage_portal; pfam04860 932919005750 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 932919005751 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 932919005752 ParB-like nuclease domain; Region: ParBc; pfam02195 932919005753 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 932919005754 DNA methylase; Region: N6_N4_Mtase; pfam01555 932919005755 HNH endonuclease; Region: HNH_3; pfam13392 932919005756 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 932919005757 Phage terminase, small subunit; Region: Terminase_4; cl01525 932919005758 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 932919005759 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 932919005760 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932919005761 ATP binding site [chemical binding]; other site 932919005762 putative Mg++ binding site [ion binding]; other site 932919005763 VRR-NUC domain; Region: VRR_NUC; pfam08774 932919005764 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 932919005765 D5 N terminal like; Region: D5_N; pfam08706 932919005766 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 932919005767 Prophage antirepressor [Transcription]; Region: COG3617 932919005768 BRO family, N-terminal domain; Region: Bro-N; pfam02498 932919005769 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 932919005770 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 932919005771 active site 932919005772 DNA binding site [nucleotide binding] 932919005773 catalytic site [active] 932919005774 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 932919005775 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 932919005776 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 932919005777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919005778 Walker A/P-loop; other site 932919005779 ATP binding site [chemical binding]; other site 932919005780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919005781 non-specific DNA binding site [nucleotide binding]; other site 932919005782 salt bridge; other site 932919005783 sequence-specific DNA binding site [nucleotide binding]; other site 932919005784 T5orf172 domain; Region: T5orf172; pfam10544 932919005785 DEAD-like helicases superfamily; Region: DEXDc; smart00487 932919005786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932919005787 ATP binding site [chemical binding]; other site 932919005788 putative Mg++ binding site [ion binding]; other site 932919005789 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 932919005790 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 932919005791 non-specific DNA binding site [nucleotide binding]; other site 932919005792 salt bridge; other site 932919005793 sequence-specific DNA binding site [nucleotide binding]; other site 932919005794 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 932919005795 GIY-YIG motif/motif A; other site 932919005796 putative active site [active] 932919005797 putative metal binding site [ion binding]; other site 932919005798 TRAM domain; Region: TRAM; cl01282 932919005799 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 932919005800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919005801 S-adenosylmethionine binding site [chemical binding]; other site 932919005802 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 932919005803 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 932919005804 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 932919005805 Substrate-binding site [chemical binding]; other site 932919005806 Substrate specificity [chemical binding]; other site 932919005807 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 932919005808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 932919005809 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 932919005810 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 932919005811 active site 932919005812 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 932919005813 flavodoxin, short chain; Region: flav_short; TIGR01753 932919005814 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 932919005815 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 932919005816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919005817 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932919005818 putative substrate translocation pore; other site 932919005819 rod-share determining protein MreBH; Provisional; Region: PRK13929 932919005820 MreB and similar proteins; Region: MreB_like; cd10225 932919005821 nucleotide binding site [chemical binding]; other site 932919005822 Mg binding site [ion binding]; other site 932919005823 putative protofilament interaction site [polypeptide binding]; other site 932919005824 RodZ interaction site [polypeptide binding]; other site 932919005825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919005826 S-adenosylmethionine binding site [chemical binding]; other site 932919005827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932919005828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932919005829 Uncharacterized conserved protein [Function unknown]; Region: COG3589 932919005830 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 932919005831 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932919005832 methionine cluster; other site 932919005833 active site 932919005834 phosphorylation site [posttranslational modification] 932919005835 metal binding site [ion binding]; metal-binding site 932919005836 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932919005837 active site 932919005838 P-loop; other site 932919005839 phosphorylation site [posttranslational modification] 932919005840 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 932919005841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919005842 Walker A motif; other site 932919005843 ATP binding site [chemical binding]; other site 932919005844 Walker B motif; other site 932919005845 arginine finger; other site 932919005846 Transcriptional antiterminator [Transcription]; Region: COG3933 932919005847 PRD domain; Region: PRD; pfam00874 932919005848 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 932919005849 active pocket/dimerization site; other site 932919005850 active site 932919005851 phosphorylation site [posttranslational modification] 932919005852 PRD domain; Region: PRD; pfam00874 932919005853 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 932919005854 DEAD-like helicases superfamily; Region: DEXDc; smart00487 932919005855 ATP binding site [chemical binding]; other site 932919005856 putative Mg++ binding site [ion binding]; other site 932919005857 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932919005858 nucleotide binding region [chemical binding]; other site 932919005859 ATP-binding site [chemical binding]; other site 932919005860 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932919005861 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932919005862 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932919005863 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932919005864 DNA binding site [nucleotide binding] 932919005865 domain linker motif; other site 932919005866 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 932919005867 dimerization interface [polypeptide binding]; other site 932919005868 ligand binding site [chemical binding]; other site 932919005869 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 932919005870 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 932919005871 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 932919005872 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 932919005873 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 932919005874 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932919005875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919005876 dimer interface [polypeptide binding]; other site 932919005877 conserved gate region; other site 932919005878 putative PBP binding loops; other site 932919005879 ABC-ATPase subunit interface; other site 932919005880 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932919005881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919005882 dimer interface [polypeptide binding]; other site 932919005883 conserved gate region; other site 932919005884 putative PBP binding loops; other site 932919005885 ABC-ATPase subunit interface; other site 932919005886 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 932919005887 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 932919005888 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 932919005889 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 932919005890 active site 932919005891 dimer interface [polypeptide binding]; other site 932919005892 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 932919005893 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 932919005894 active site 932919005895 FMN binding site [chemical binding]; other site 932919005896 substrate binding site [chemical binding]; other site 932919005897 3Fe-4S cluster binding site [ion binding]; other site 932919005898 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 932919005899 domain interface; other site 932919005900 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932919005901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932919005902 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 932919005903 putative dimerization interface [polypeptide binding]; other site 932919005904 Predicted acetyltransferase [General function prediction only]; Region: COG3153 932919005905 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 932919005906 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 932919005907 putative active site [active] 932919005908 metal binding site [ion binding]; metal-binding site 932919005909 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932919005910 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932919005911 substrate binding pocket [chemical binding]; other site 932919005912 membrane-bound complex binding site; other site 932919005913 hinge residues; other site 932919005914 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932919005915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919005916 Walker A/P-loop; other site 932919005917 ATP binding site [chemical binding]; other site 932919005918 Q-loop/lid; other site 932919005919 ABC transporter signature motif; other site 932919005920 Walker B; other site 932919005921 D-loop; other site 932919005922 H-loop/switch region; other site 932919005923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919005924 dimer interface [polypeptide binding]; other site 932919005925 conserved gate region; other site 932919005926 putative PBP binding loops; other site 932919005927 ABC-ATPase subunit interface; other site 932919005928 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 932919005929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 932919005930 dimer interface [polypeptide binding]; other site 932919005931 phosphorylation site [posttranslational modification] 932919005932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919005933 ATP binding site [chemical binding]; other site 932919005934 Mg2+ binding site [ion binding]; other site 932919005935 G-X-G motif; other site 932919005936 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 932919005937 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 932919005938 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 932919005939 active site 932919005940 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 932919005941 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 932919005942 putative NAD(P) binding site [chemical binding]; other site 932919005943 active site 932919005944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932919005945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919005946 active site 932919005947 phosphorylation site [posttranslational modification] 932919005948 intermolecular recognition site; other site 932919005949 dimerization interface [polypeptide binding]; other site 932919005950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932919005951 DNA binding site [nucleotide binding] 932919005952 FtsX-like permease family; Region: FtsX; pfam02687 932919005953 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 932919005954 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932919005955 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932919005956 Walker A/P-loop; other site 932919005957 ATP binding site [chemical binding]; other site 932919005958 Q-loop/lid; other site 932919005959 ABC transporter signature motif; other site 932919005960 Walker B; other site 932919005961 D-loop; other site 932919005962 H-loop/switch region; other site 932919005963 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 932919005964 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 932919005965 ADP binding site [chemical binding]; other site 932919005966 magnesium binding site [ion binding]; other site 932919005967 putative shikimate binding site; other site 932919005968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 932919005969 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 932919005970 TRAM domain; Region: TRAM; pfam01938 932919005971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919005972 S-adenosylmethionine binding site [chemical binding]; other site 932919005973 putative lipid kinase; Reviewed; Region: PRK13337 932919005974 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 932919005975 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 932919005976 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 932919005977 GatB domain; Region: GatB_Yqey; smart00845 932919005978 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 932919005979 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 932919005980 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 932919005981 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 932919005982 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 932919005983 putative dimer interface [polypeptide binding]; other site 932919005984 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 932919005985 putative dimer interface [polypeptide binding]; other site 932919005986 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 932919005987 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 932919005988 nucleotide binding pocket [chemical binding]; other site 932919005989 K-X-D-G motif; other site 932919005990 catalytic site [active] 932919005991 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 932919005992 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 932919005993 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 932919005994 Dimer interface [polypeptide binding]; other site 932919005995 BRCT sequence motif; other site 932919005996 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 932919005997 Part of AAA domain; Region: AAA_19; pfam13245 932919005998 Family description; Region: UvrD_C_2; pfam13538 932919005999 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 932919006000 PcrB family; Region: PcrB; pfam01884 932919006001 substrate binding site [chemical binding]; other site 932919006002 putative active site [active] 932919006003 dimer interface [polypeptide binding]; other site 932919006004 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 932919006005 Na2 binding site [ion binding]; other site 932919006006 putative substrate binding site 1 [chemical binding]; other site 932919006007 Na binding site 1 [ion binding]; other site 932919006008 putative substrate binding site 2 [chemical binding]; other site 932919006009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 932919006010 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 932919006011 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 932919006012 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 932919006013 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 932919006014 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 932919006015 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 932919006016 purine monophosphate binding site [chemical binding]; other site 932919006017 dimer interface [polypeptide binding]; other site 932919006018 putative catalytic residues [active] 932919006019 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 932919006020 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 932919006021 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 932919006022 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 932919006023 active site 932919006024 substrate binding site [chemical binding]; other site 932919006025 cosubstrate binding site; other site 932919006026 catalytic site [active] 932919006027 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 932919006028 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 932919006029 dimerization interface [polypeptide binding]; other site 932919006030 putative ATP binding site [chemical binding]; other site 932919006031 amidophosphoribosyltransferase; Provisional; Region: PRK06781 932919006032 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 932919006033 active site 932919006034 tetramer interface [polypeptide binding]; other site 932919006035 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932919006036 active site 932919006037 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 932919006038 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 932919006039 dimerization interface [polypeptide binding]; other site 932919006040 ATP binding site [chemical binding]; other site 932919006041 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 932919006042 dimerization interface [polypeptide binding]; other site 932919006043 ATP binding site [chemical binding]; other site 932919006044 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 932919006045 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 932919006046 putative active site [active] 932919006047 catalytic triad [active] 932919006048 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 932919006049 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 932919006050 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 932919006051 ATP binding site [chemical binding]; other site 932919006052 active site 932919006053 substrate binding site [chemical binding]; other site 932919006054 adenylosuccinate lyase; Provisional; Region: PRK07492 932919006055 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 932919006056 tetramer interface [polypeptide binding]; other site 932919006057 active site 932919006058 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 932919006059 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 932919006060 NAD binding site [chemical binding]; other site 932919006061 ATP-grasp domain; Region: ATP-grasp; pfam02222 932919006062 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 932919006063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 932919006064 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 932919006065 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 932919006066 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932919006067 Zn2+ binding site [ion binding]; other site 932919006068 Mg2+ binding site [ion binding]; other site 932919006069 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 932919006070 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 932919006071 Walker A/P-loop; other site 932919006072 ATP binding site [chemical binding]; other site 932919006073 Q-loop/lid; other site 932919006074 ABC transporter signature motif; other site 932919006075 Walker B; other site 932919006076 D-loop; other site 932919006077 H-loop/switch region; other site 932919006078 peptidase T; Region: peptidase-T; TIGR01882 932919006079 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 932919006080 metal binding site [ion binding]; metal-binding site 932919006081 dimer interface [polypeptide binding]; other site 932919006082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 932919006083 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 932919006084 active site 932919006085 putative catalytic site [active] 932919006086 DNA binding site [nucleotide binding] 932919006087 putative phosphate binding site [ion binding]; other site 932919006088 metal binding site A [ion binding]; metal-binding site 932919006089 AP binding site [nucleotide binding]; other site 932919006090 metal binding site B [ion binding]; metal-binding site 932919006091 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 932919006092 23S rRNA binding site [nucleotide binding]; other site 932919006093 L21 binding site [polypeptide binding]; other site 932919006094 L13 binding site [polypeptide binding]; other site 932919006095 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 932919006096 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 932919006097 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 932919006098 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 932919006099 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932919006100 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919006101 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932919006102 Substrate binding site [chemical binding]; other site 932919006103 Leucine rich repeat; Region: LRR_8; pfam13855 932919006104 LRR adjacent; Region: LRR_adjacent; pfam08191 932919006105 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 932919006106 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 932919006107 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 932919006108 DNA binding residues [nucleotide binding] 932919006109 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 932919006110 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 932919006111 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932919006112 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 932919006113 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 932919006114 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 932919006115 RimM N-terminal domain; Region: RimM; pfam01782 932919006116 PRC-barrel domain; Region: PRC; pfam05239 932919006117 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 932919006118 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 932919006119 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 932919006120 catalytic triad [active] 932919006121 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 932919006122 KH domain; Region: KH_4; pfam13083 932919006123 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 932919006124 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 932919006125 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 932919006126 signal recognition particle protein; Provisional; Region: PRK10867 932919006127 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 932919006128 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 932919006129 P loop; other site 932919006130 GTP binding site [chemical binding]; other site 932919006131 Signal peptide binding domain; Region: SRP_SPB; pfam02978 932919006132 putative DNA-binding protein; Validated; Region: PRK00118 932919006133 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 932919006134 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 932919006135 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 932919006136 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 932919006137 P loop; other site 932919006138 GTP binding site [chemical binding]; other site 932919006139 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 932919006140 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 932919006141 Walker A/P-loop; other site 932919006142 ATP binding site [chemical binding]; other site 932919006143 Q-loop/lid; other site 932919006144 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 932919006145 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 932919006146 linker region; other site 932919006147 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 932919006148 ABC transporter signature motif; other site 932919006149 Walker B; other site 932919006150 D-loop; other site 932919006151 H-loop/switch region; other site 932919006152 ribonuclease III; Reviewed; Region: rnc; PRK00102 932919006153 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 932919006154 dimerization interface [polypeptide binding]; other site 932919006155 active site 932919006156 metal binding site [ion binding]; metal-binding site 932919006157 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 932919006158 dsRNA binding site [nucleotide binding]; other site 932919006159 acyl carrier protein; Provisional; Region: acpP; PRK00982 932919006160 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 932919006161 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 932919006162 NAD(P) binding site [chemical binding]; other site 932919006163 homotetramer interface [polypeptide binding]; other site 932919006164 homodimer interface [polypeptide binding]; other site 932919006165 active site 932919006166 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 932919006167 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 932919006168 putative phosphate acyltransferase; Provisional; Region: PRK05331 932919006169 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 932919006170 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 932919006171 active site 2 [active] 932919006172 active site 1 [active] 932919006173 Y-family of DNA polymerases; Region: PolY; cl12025 932919006174 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 932919006175 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 932919006176 generic binding surface II; other site 932919006177 ssDNA binding site; other site 932919006178 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932919006179 ATP binding site [chemical binding]; other site 932919006180 putative Mg++ binding site [ion binding]; other site 932919006181 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932919006182 nucleotide binding region [chemical binding]; other site 932919006183 ATP-binding site [chemical binding]; other site 932919006184 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 932919006185 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 932919006186 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 932919006187 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 932919006188 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 932919006189 putative L-serine binding site [chemical binding]; other site 932919006190 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 932919006191 DAK2 domain; Region: Dak2; pfam02734 932919006192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 932919006193 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 932919006194 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 932919006195 Thiamine pyrophosphokinase; Region: TPK; cd07995 932919006196 active site 932919006197 dimerization interface [polypeptide binding]; other site 932919006198 thiamine binding site [chemical binding]; other site 932919006199 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 932919006200 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 932919006201 substrate binding site [chemical binding]; other site 932919006202 hexamer interface [polypeptide binding]; other site 932919006203 metal binding site [ion binding]; metal-binding site 932919006204 GTPase RsgA; Reviewed; Region: PRK00098 932919006205 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 932919006206 RNA binding site [nucleotide binding]; other site 932919006207 homodimer interface [polypeptide binding]; other site 932919006208 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 932919006209 GTPase/Zn-binding domain interface [polypeptide binding]; other site 932919006210 GTP/Mg2+ binding site [chemical binding]; other site 932919006211 G4 box; other site 932919006212 G1 box; other site 932919006213 Switch I region; other site 932919006214 G2 box; other site 932919006215 G3 box; other site 932919006216 Switch II region; other site 932919006217 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 932919006218 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 932919006219 active site 932919006220 ATP binding site [chemical binding]; other site 932919006221 substrate binding site [chemical binding]; other site 932919006222 activation loop (A-loop); other site 932919006223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 932919006224 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 932919006225 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 932919006226 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 932919006227 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 932919006228 Protein phosphatase 2C; Region: PP2C; pfam00481 932919006229 active site 932919006230 16S rRNA methyltransferase B; Provisional; Region: PRK14902 932919006231 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 932919006232 putative RNA binding site [nucleotide binding]; other site 932919006233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919006234 S-adenosylmethionine binding site [chemical binding]; other site 932919006235 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 932919006236 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 932919006237 putative active site [active] 932919006238 substrate binding site [chemical binding]; other site 932919006239 putative cosubstrate binding site; other site 932919006240 catalytic site [active] 932919006241 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 932919006242 substrate binding site [chemical binding]; other site 932919006243 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 932919006244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932919006245 ATP binding site [chemical binding]; other site 932919006246 putative Mg++ binding site [ion binding]; other site 932919006247 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932919006248 ATP-binding site [chemical binding]; other site 932919006249 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 932919006250 Flavoprotein; Region: Flavoprotein; pfam02441 932919006251 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 932919006252 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 932919006253 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 932919006254 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 932919006255 catalytic site [active] 932919006256 G-X2-G-X-G-K; other site 932919006257 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 932919006258 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 932919006259 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 932919006260 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 932919006261 Domain of unknown function (DUF814); Region: DUF814; pfam05670 932919006262 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 932919006263 putative NAD(P) binding site [chemical binding]; other site 932919006264 homodimer interface [polypeptide binding]; other site 932919006265 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932919006266 active site 932919006267 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 932919006268 active site 932919006269 dimer interface [polypeptide binding]; other site 932919006270 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 932919006271 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 932919006272 heterodimer interface [polypeptide binding]; other site 932919006273 active site 932919006274 FMN binding site [chemical binding]; other site 932919006275 homodimer interface [polypeptide binding]; other site 932919006276 substrate binding site [chemical binding]; other site 932919006277 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 932919006278 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 932919006279 FAD binding pocket [chemical binding]; other site 932919006280 FAD binding motif [chemical binding]; other site 932919006281 phosphate binding motif [ion binding]; other site 932919006282 beta-alpha-beta structure motif; other site 932919006283 NAD binding pocket [chemical binding]; other site 932919006284 Iron coordination center [ion binding]; other site 932919006285 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 932919006286 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 932919006287 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 932919006288 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 932919006289 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 932919006290 ATP-grasp domain; Region: ATP-grasp_4; cl17255 932919006291 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 932919006292 IMP binding site; other site 932919006293 dimer interface [polypeptide binding]; other site 932919006294 interdomain contacts; other site 932919006295 partial ornithine binding site; other site 932919006296 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 932919006297 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 932919006298 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 932919006299 catalytic site [active] 932919006300 subunit interface [polypeptide binding]; other site 932919006301 dihydroorotase; Validated; Region: pyrC; PRK09357 932919006302 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 932919006303 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 932919006304 active site 932919006305 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 932919006306 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 932919006307 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 932919006308 uracil transporter; Provisional; Region: PRK10720 932919006309 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 932919006310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932919006311 active site 932919006312 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 932919006313 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 932919006314 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932919006315 RNA binding surface [nucleotide binding]; other site 932919006316 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 932919006317 active site 932919006318 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 932919006319 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 932919006320 Sulfate transporter family; Region: Sulfate_transp; pfam00916 932919006321 multidrug efflux protein; Reviewed; Region: PRK01766 932919006322 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 932919006323 cation binding site [ion binding]; other site 932919006324 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 932919006325 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 932919006326 metal binding site [ion binding]; metal-binding site 932919006327 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 932919006328 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932919006329 ABC-ATPase subunit interface; other site 932919006330 dimer interface [polypeptide binding]; other site 932919006331 putative PBP binding regions; other site 932919006332 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 932919006333 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 932919006334 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932919006335 MarR family; Region: MarR; pfam01047 932919006336 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 932919006337 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 932919006338 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 932919006339 protein binding site [polypeptide binding]; other site 932919006340 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 932919006341 Catalytic dyad [active] 932919006342 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 932919006343 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 932919006344 metal-binding site [ion binding] 932919006345 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 932919006346 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 932919006347 metal-binding site [ion binding] 932919006348 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932919006349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919006350 motif II; other site 932919006351 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 932919006352 putative homodimer interface [polypeptide binding]; other site 932919006353 putative homotetramer interface [polypeptide binding]; other site 932919006354 putative allosteric switch controlling residues; other site 932919006355 putative metal binding site [ion binding]; other site 932919006356 putative homodimer-homodimer interface [polypeptide binding]; other site 932919006357 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 932919006358 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 932919006359 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 932919006360 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 932919006361 hypothetical protein; Provisional; Region: PRK13672 932919006362 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932919006363 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932919006364 methionine sulfoxide reductase B; Provisional; Region: PRK00222 932919006365 SelR domain; Region: SelR; pfam01641 932919006366 methionine sulfoxide reductase A; Provisional; Region: PRK14054 932919006367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 932919006368 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 932919006369 active site 932919006370 catalytic triad [active] 932919006371 oxyanion hole [active] 932919006372 EDD domain protein, DegV family; Region: DegV; TIGR00762 932919006373 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 932919006374 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 932919006375 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 932919006376 HTH domain; Region: HTH_11; pfam08279 932919006377 FOG: CBS domain [General function prediction only]; Region: COG0517 932919006378 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 932919006379 PEP synthetase regulatory protein; Provisional; Region: PRK05339 932919006380 pyruvate phosphate dikinase; Provisional; Region: PRK09279 932919006381 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 932919006382 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 932919006383 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 932919006384 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932919006385 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 932919006386 Predicted membrane protein [Function unknown]; Region: COG4129 932919006387 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 932919006388 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 932919006389 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 932919006390 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 932919006391 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 932919006392 active site 932919006393 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 932919006394 substrate binding site [chemical binding]; other site 932919006395 metal binding site [ion binding]; metal-binding site 932919006396 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 932919006397 Methyltransferase domain; Region: Methyltransf_18; pfam12847 932919006398 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 932919006399 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 932919006400 folate binding site [chemical binding]; other site 932919006401 NADP+ binding site [chemical binding]; other site 932919006402 thymidylate synthase; Region: thym_sym; TIGR03284 932919006403 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 932919006404 dimerization interface [polypeptide binding]; other site 932919006405 active site 932919006406 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 932919006407 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 932919006408 Walker A/P-loop; other site 932919006409 ATP binding site [chemical binding]; other site 932919006410 Q-loop/lid; other site 932919006411 ABC transporter signature motif; other site 932919006412 Walker B; other site 932919006413 D-loop; other site 932919006414 H-loop/switch region; other site 932919006415 ABC transporter; Region: ABC_tran_2; pfam12848 932919006416 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932919006417 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 932919006418 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 932919006419 Potassium binding sites [ion binding]; other site 932919006420 Cesium cation binding sites [ion binding]; other site 932919006421 manganese transport transcriptional regulator; Provisional; Region: PRK03902 932919006422 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 932919006423 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 932919006424 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 932919006425 DNA-binding site [nucleotide binding]; DNA binding site 932919006426 RNA-binding motif; other site 932919006427 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 932919006428 RNA/DNA hybrid binding site [nucleotide binding]; other site 932919006429 active site 932919006430 5'-3' exonuclease; Region: 53EXOc; smart00475 932919006431 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 932919006432 active site 932919006433 metal binding site 1 [ion binding]; metal-binding site 932919006434 putative 5' ssDNA interaction site; other site 932919006435 metal binding site 3; metal-binding site 932919006436 metal binding site 2 [ion binding]; metal-binding site 932919006437 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 932919006438 putative DNA binding site [nucleotide binding]; other site 932919006439 putative metal binding site [ion binding]; other site 932919006440 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 932919006441 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 932919006442 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 932919006443 putative active site [active] 932919006444 xanthine permease; Region: pbuX; TIGR03173 932919006445 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932919006446 active site 932919006447 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 932919006448 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 932919006449 active site 932919006450 Zn binding site [ion binding]; other site 932919006451 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 932919006452 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 932919006453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 932919006454 cell division protein GpsB; Provisional; Region: PRK14127 932919006455 DivIVA domain; Region: DivI1A_domain; TIGR03544 932919006456 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 932919006457 hypothetical protein; Provisional; Region: PRK13660 932919006458 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 932919006459 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 932919006460 Transglycosylase; Region: Transgly; pfam00912 932919006461 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 932919006462 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 932919006463 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 932919006464 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 932919006465 minor groove reading motif; other site 932919006466 helix-hairpin-helix signature motif; other site 932919006467 substrate binding pocket [chemical binding]; other site 932919006468 active site 932919006469 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 932919006470 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 932919006471 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 932919006472 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 932919006473 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 932919006474 putative dimer interface [polypeptide binding]; other site 932919006475 putative anticodon binding site; other site 932919006476 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 932919006477 homodimer interface [polypeptide binding]; other site 932919006478 motif 1; other site 932919006479 motif 2; other site 932919006480 active site 932919006481 motif 3; other site 932919006482 aspartate aminotransferase; Provisional; Region: PRK05764 932919006483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932919006484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919006485 homodimer interface [polypeptide binding]; other site 932919006486 catalytic residue [active] 932919006487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 932919006488 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 932919006489 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 932919006490 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 932919006491 active site 932919006492 catalytic site [active] 932919006493 substrate binding site [chemical binding]; other site 932919006494 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 932919006495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 932919006496 putative Mg++ binding site [ion binding]; other site 932919006497 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 932919006498 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 932919006499 tetramerization interface [polypeptide binding]; other site 932919006500 active site 932919006501 pantoate--beta-alanine ligase; Region: panC; TIGR00018 932919006502 Pantoate-beta-alanine ligase; Region: PanC; cd00560 932919006503 active site 932919006504 ATP-binding site [chemical binding]; other site 932919006505 pantoate-binding site; other site 932919006506 HXXH motif; other site 932919006507 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 932919006508 active site 932919006509 oligomerization interface [polypeptide binding]; other site 932919006510 metal binding site [ion binding]; metal-binding site 932919006511 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 932919006512 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 932919006513 catalytic residues [active] 932919006514 Biotin operon repressor [Transcription]; Region: BirA; COG1654 932919006515 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 932919006516 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 932919006517 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 932919006518 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 932919006519 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 932919006520 active site 932919006521 NTP binding site [chemical binding]; other site 932919006522 metal binding triad [ion binding]; metal-binding site 932919006523 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 932919006524 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 932919006525 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 932919006526 active site 932919006527 dimer interfaces [polypeptide binding]; other site 932919006528 catalytic residues [active] 932919006529 dihydrodipicolinate reductase; Provisional; Region: PRK00048 932919006530 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 932919006531 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 932919006532 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 932919006533 homodimer interface [polypeptide binding]; other site 932919006534 metal binding site [ion binding]; metal-binding site 932919006535 Uncharacterized conserved protein [Function unknown]; Region: COG1284 932919006536 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 932919006537 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 932919006538 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 932919006539 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 932919006540 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932919006541 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932919006542 metal binding site [ion binding]; metal-binding site 932919006543 active site 932919006544 I-site; other site 932919006545 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 932919006546 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932919006547 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932919006548 metal binding site [ion binding]; metal-binding site 932919006549 active site 932919006550 I-site; other site 932919006551 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932919006552 malate dehydrogenase; Provisional; Region: PRK13529 932919006553 Malic enzyme, N-terminal domain; Region: malic; pfam00390 932919006554 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 932919006555 NAD(P) binding pocket [chemical binding]; other site 932919006556 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 932919006557 Beta-lactamase; Region: Beta-lactamase; pfam00144 932919006558 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 932919006559 Pyruvate formate lyase 1; Region: PFL1; cd01678 932919006560 coenzyme A binding site [chemical binding]; other site 932919006561 active site 932919006562 catalytic residues [active] 932919006563 glycine loop; other site 932919006564 HI0933-like protein; Region: HI0933_like; pfam03486 932919006565 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932919006566 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 932919006567 Predicted membrane protein [Function unknown]; Region: COG4347 932919006568 hypothetical protein; Provisional; Region: PRK03636 932919006569 UPF0302 domain; Region: UPF0302; pfam08864 932919006570 IDEAL domain; Region: IDEAL; pfam08858 932919006571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 932919006572 binding surface 932919006573 TPR motif; other site 932919006574 TPR repeat; Region: TPR_11; pfam13414 932919006575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932919006576 binding surface 932919006577 TPR motif; other site 932919006578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 932919006579 binding surface 932919006580 TPR motif; other site 932919006581 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 932919006582 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 932919006583 hinge; other site 932919006584 active site 932919006585 prephenate dehydrogenase; Validated; Region: PRK06545 932919006586 prephenate dehydrogenase; Validated; Region: PRK08507 932919006587 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 932919006588 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 932919006589 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932919006590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919006591 homodimer interface [polypeptide binding]; other site 932919006592 catalytic residue [active] 932919006593 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 932919006594 homotrimer interaction site [polypeptide binding]; other site 932919006595 active site 932919006596 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 932919006597 active site 932919006598 dimer interface [polypeptide binding]; other site 932919006599 metal binding site [ion binding]; metal-binding site 932919006600 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 932919006601 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 932919006602 Tetramer interface [polypeptide binding]; other site 932919006603 active site 932919006604 FMN-binding site [chemical binding]; other site 932919006605 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 932919006606 active site 932919006607 multimer interface [polypeptide binding]; other site 932919006608 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 932919006609 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 932919006610 substrate binding pocket [chemical binding]; other site 932919006611 chain length determination region; other site 932919006612 substrate-Mg2+ binding site; other site 932919006613 catalytic residues [active] 932919006614 aspartate-rich region 1; other site 932919006615 active site lid residues [active] 932919006616 aspartate-rich region 2; other site 932919006617 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 932919006618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919006619 S-adenosylmethionine binding site [chemical binding]; other site 932919006620 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 932919006621 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 932919006622 homodecamer interface [polypeptide binding]; other site 932919006623 GTP cyclohydrolase I; Provisional; Region: PLN03044 932919006624 active site 932919006625 putative catalytic site residues [active] 932919006626 zinc binding site [ion binding]; other site 932919006627 GTP-CH-I/GFRP interaction surface; other site 932919006628 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 932919006629 IHF dimer interface [polypeptide binding]; other site 932919006630 IHF - DNA interface [nucleotide binding]; other site 932919006631 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 932919006632 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 932919006633 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 932919006634 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 932919006635 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 932919006636 GTP-binding protein Der; Reviewed; Region: PRK00093 932919006637 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 932919006638 G1 box; other site 932919006639 GTP/Mg2+ binding site [chemical binding]; other site 932919006640 Switch I region; other site 932919006641 G2 box; other site 932919006642 Switch II region; other site 932919006643 G3 box; other site 932919006644 G4 box; other site 932919006645 G5 box; other site 932919006646 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 932919006647 G1 box; other site 932919006648 GTP/Mg2+ binding site [chemical binding]; other site 932919006649 Switch I region; other site 932919006650 G2 box; other site 932919006651 G3 box; other site 932919006652 Switch II region; other site 932919006653 G4 box; other site 932919006654 G5 box; other site 932919006655 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 932919006656 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 932919006657 RNA binding site [nucleotide binding]; other site 932919006658 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 932919006659 RNA binding site [nucleotide binding]; other site 932919006660 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 932919006661 RNA binding site [nucleotide binding]; other site 932919006662 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 932919006663 RNA binding site [nucleotide binding]; other site 932919006664 cytidylate kinase; Provisional; Region: cmk; PRK00023 932919006665 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 932919006666 CMP-binding site; other site 932919006667 The sites determining sugar specificity; other site 932919006668 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 932919006669 active site 932919006670 homotetramer interface [polypeptide binding]; other site 932919006671 homodimer interface [polypeptide binding]; other site 932919006672 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932919006673 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 932919006674 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 932919006675 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932919006676 ATP binding site [chemical binding]; other site 932919006677 putative Mg++ binding site [ion binding]; other site 932919006678 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932919006679 nucleotide binding region [chemical binding]; other site 932919006680 ATP-binding site [chemical binding]; other site 932919006681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 932919006682 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919006683 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919006684 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919006685 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919006686 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919006687 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919006688 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919006689 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919006690 Predicted membrane protein [Function unknown]; Region: COG3601 932919006691 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 932919006692 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 932919006693 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932919006694 dimerization interface [polypeptide binding]; other site 932919006695 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 932919006696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932919006697 dimer interface [polypeptide binding]; other site 932919006698 phosphorylation site [posttranslational modification] 932919006699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919006700 ATP binding site [chemical binding]; other site 932919006701 Mg2+ binding site [ion binding]; other site 932919006702 G-X-G motif; other site 932919006703 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932919006704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919006705 active site 932919006706 phosphorylation site [posttranslational modification] 932919006707 intermolecular recognition site; other site 932919006708 dimerization interface [polypeptide binding]; other site 932919006709 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932919006710 DNA binding site [nucleotide binding] 932919006711 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 932919006712 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932919006713 RNA binding surface [nucleotide binding]; other site 932919006714 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 932919006715 active site 932919006716 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 932919006717 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 932919006718 diaminopimelate decarboxylase; Region: lysA; TIGR01048 932919006719 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 932919006720 active site 932919006721 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 932919006722 substrate binding site [chemical binding]; other site 932919006723 catalytic residues [active] 932919006724 dimer interface [polypeptide binding]; other site 932919006725 purine nucleoside phosphorylase; Provisional; Region: PRK08202 932919006726 phosphopentomutase; Provisional; Region: PRK05362 932919006727 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 932919006728 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 932919006729 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 932919006730 active site 932919006731 Int/Topo IB signature motif; other site 932919006732 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 932919006733 metal binding site 2 [ion binding]; metal-binding site 932919006734 putative DNA binding helix; other site 932919006735 metal binding site 1 [ion binding]; metal-binding site 932919006736 dimer interface [polypeptide binding]; other site 932919006737 structural Zn2+ binding site [ion binding]; other site 932919006738 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 932919006739 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932919006740 ABC-ATPase subunit interface; other site 932919006741 dimer interface [polypeptide binding]; other site 932919006742 putative PBP binding regions; other site 932919006743 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 932919006744 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932919006745 ABC-ATPase subunit interface; other site 932919006746 dimer interface [polypeptide binding]; other site 932919006747 putative PBP binding regions; other site 932919006748 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 932919006749 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 932919006750 putative ligand binding residues [chemical binding]; other site 932919006751 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 932919006752 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 932919006753 Walker A/P-loop; other site 932919006754 ATP binding site [chemical binding]; other site 932919006755 Q-loop/lid; other site 932919006756 ABC transporter signature motif; other site 932919006757 Walker B; other site 932919006758 D-loop; other site 932919006759 H-loop/switch region; other site 932919006760 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 932919006761 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932919006762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932919006763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932919006764 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 932919006765 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 932919006766 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 932919006767 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 932919006768 Walker A/P-loop; other site 932919006769 ATP binding site [chemical binding]; other site 932919006770 Q-loop/lid; other site 932919006771 ABC transporter signature motif; other site 932919006772 Walker B; other site 932919006773 D-loop; other site 932919006774 H-loop/switch region; other site 932919006775 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 932919006776 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 932919006777 dimer interface [polypeptide binding]; other site 932919006778 ADP-ribose binding site [chemical binding]; other site 932919006779 active site 932919006780 nudix motif; other site 932919006781 metal binding site [ion binding]; metal-binding site 932919006782 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 932919006783 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 932919006784 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 932919006785 active site 932919006786 DNA polymerase IV; Validated; Region: PRK02406 932919006787 DNA binding site [nucleotide binding] 932919006788 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 932919006789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932919006790 NAD(P) binding site [chemical binding]; other site 932919006791 active site 932919006792 ribonuclease Z; Region: RNase_Z; TIGR02651 932919006793 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 932919006794 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 932919006795 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 932919006796 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 932919006797 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932919006798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919006799 Coenzyme A binding pocket [chemical binding]; other site 932919006800 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 932919006801 6-phosphogluconate dehydratase; Region: edd; TIGR01196 932919006802 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 932919006803 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 932919006804 PYR/PP interface [polypeptide binding]; other site 932919006805 dimer interface [polypeptide binding]; other site 932919006806 TPP binding site [chemical binding]; other site 932919006807 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 932919006808 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 932919006809 TPP-binding site [chemical binding]; other site 932919006810 dimer interface [polypeptide binding]; other site 932919006811 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 932919006812 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 932919006813 putative valine binding site [chemical binding]; other site 932919006814 dimer interface [polypeptide binding]; other site 932919006815 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 932919006816 ketol-acid reductoisomerase; Provisional; Region: PRK05479 932919006817 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 932919006818 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 932919006819 2-isopropylmalate synthase; Validated; Region: PRK00915 932919006820 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 932919006821 active site 932919006822 catalytic residues [active] 932919006823 metal binding site [ion binding]; metal-binding site 932919006824 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 932919006825 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 932919006826 tartrate dehydrogenase; Region: TTC; TIGR02089 932919006827 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 932919006828 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 932919006829 substrate binding site [chemical binding]; other site 932919006830 ligand binding site [chemical binding]; other site 932919006831 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 932919006832 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 932919006833 substrate binding site [chemical binding]; other site 932919006834 threonine dehydratase; Validated; Region: PRK08639 932919006835 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 932919006836 tetramer interface [polypeptide binding]; other site 932919006837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919006838 catalytic residue [active] 932919006839 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 932919006840 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 932919006841 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 932919006842 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 932919006843 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 932919006844 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 932919006845 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932919006846 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932919006847 DNA binding site [nucleotide binding] 932919006848 domain linker motif; other site 932919006849 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 932919006850 dimerization interface [polypeptide binding]; other site 932919006851 ligand binding site [chemical binding]; other site 932919006852 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 932919006853 intersubunit interface [polypeptide binding]; other site 932919006854 active site 932919006855 catalytic residue [active] 932919006856 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 932919006857 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 932919006858 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 932919006859 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 932919006860 active pocket/dimerization site; other site 932919006861 active site 932919006862 phosphorylation site [posttranslational modification] 932919006863 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 932919006864 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 932919006865 putative active site [active] 932919006866 SIS domain; Region: SIS; pfam01380 932919006867 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 932919006868 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 932919006869 dimer interface [polypeptide binding]; other site 932919006870 active site 932919006871 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 932919006872 dimer interface [polypeptide binding]; other site 932919006873 active site 932919006874 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 932919006875 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 932919006876 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 932919006877 active site 932919006878 phosphorylation site [posttranslational modification] 932919006879 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932919006880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919006881 DNA-binding site [nucleotide binding]; DNA binding site 932919006882 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 932919006883 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932919006884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919006885 DNA-binding site [nucleotide binding]; DNA binding site 932919006886 UTRA domain; Region: UTRA; pfam07702 932919006887 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932919006888 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932919006889 active site 932919006890 catalytic tetrad [active] 932919006891 acetolactate synthase; Reviewed; Region: PRK08617 932919006892 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 932919006893 PYR/PP interface [polypeptide binding]; other site 932919006894 dimer interface [polypeptide binding]; other site 932919006895 TPP binding site [chemical binding]; other site 932919006896 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 932919006897 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 932919006898 TPP-binding site [chemical binding]; other site 932919006899 dimer interface [polypeptide binding]; other site 932919006900 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932919006901 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 932919006902 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 932919006903 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932919006904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919006905 dimer interface [polypeptide binding]; other site 932919006906 conserved gate region; other site 932919006907 ABC-ATPase subunit interface; other site 932919006908 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 932919006909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919006910 dimer interface [polypeptide binding]; other site 932919006911 conserved gate region; other site 932919006912 ABC-ATPase subunit interface; other site 932919006913 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 932919006914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919006915 active site 932919006916 phosphorylation site [posttranslational modification] 932919006917 intermolecular recognition site; other site 932919006918 dimerization interface [polypeptide binding]; other site 932919006919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932919006920 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 932919006921 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 932919006922 dimerization interface [polypeptide binding]; other site 932919006923 Histidine kinase; Region: His_kinase; pfam06580 932919006924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919006925 ATP binding site [chemical binding]; other site 932919006926 Mg2+ binding site [ion binding]; other site 932919006927 G-X-G motif; other site 932919006928 Predicted integral membrane protein [Function unknown]; Region: COG5578 932919006929 Uncharacterized conserved protein [Function unknown]; Region: COG3538 932919006930 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 932919006931 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 932919006932 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 932919006933 active site 932919006934 metal binding site [ion binding]; metal-binding site 932919006935 homodimer interface [polypeptide binding]; other site 932919006936 catalytic site [active] 932919006937 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 932919006938 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 932919006939 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 932919006940 active site 932919006941 catalytic site [active] 932919006942 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 932919006943 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 932919006944 DNA-binding site [nucleotide binding]; DNA binding site 932919006945 RNA-binding motif; other site 932919006946 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 932919006947 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 932919006948 active site 932919006949 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 932919006950 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 932919006951 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 932919006952 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 932919006953 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 932919006954 active site 932919006955 HIGH motif; other site 932919006956 nucleotide binding site [chemical binding]; other site 932919006957 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 932919006958 active site 932919006959 KMSKS motif; other site 932919006960 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 932919006961 tRNA binding surface [nucleotide binding]; other site 932919006962 anticodon binding site; other site 932919006963 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 932919006964 DivIVA protein; Region: DivIVA; pfam05103 932919006965 DivIVA domain; Region: DivI1A_domain; TIGR03544 932919006966 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 932919006967 HTH domain; Region: HTH_11; pfam08279 932919006968 3H domain; Region: 3H; pfam02829 932919006969 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 932919006970 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 932919006971 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932919006972 catalytic residue [active] 932919006973 L-aspartate oxidase; Provisional; Region: PRK08071 932919006974 L-aspartate oxidase; Provisional; Region: PRK06175 932919006975 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 932919006976 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 932919006977 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 932919006978 dimerization interface [polypeptide binding]; other site 932919006979 active site 932919006980 quinolinate synthetase; Provisional; Region: PRK09375 932919006981 Transposase; Region: HTH_Tnp_1; cl17663 932919006982 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 932919006983 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919006984 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919006985 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919006986 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 932919006987 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919006988 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919006989 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919006990 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919006991 Leucine rich repeat; Region: LRR_8; pfam13855 932919006992 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919006993 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 932919006994 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919006995 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919006996 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919006997 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919006998 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 932919006999 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919007000 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919007001 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919007002 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919007003 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919007004 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 932919007005 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919007006 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919007007 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919007008 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919007009 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 932919007010 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919007011 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919007012 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919007013 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 932919007014 Leucine rich repeat; Region: LRR_8; pfam13855 932919007015 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 932919007016 Mga helix-turn-helix domain; Region: Mga; pfam05043 932919007017 Methyltransferase domain; Region: Methyltransf_31; pfam13847 932919007018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919007019 S-adenosylmethionine binding site [chemical binding]; other site 932919007020 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 932919007021 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932919007022 RNA binding surface [nucleotide binding]; other site 932919007023 YGGT family; Region: YGGT; pfam02325 932919007024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 932919007025 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 932919007026 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 932919007027 catalytic residue [active] 932919007028 cell division protein FtsZ; Validated; Region: PRK09330 932919007029 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 932919007030 nucleotide binding site [chemical binding]; other site 932919007031 SulA interaction site; other site 932919007032 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 932919007033 Cell division protein FtsA; Region: FtsA; smart00842 932919007034 Cell division protein FtsA; Region: FtsA; pfam14450 932919007035 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 932919007036 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 932919007037 Cell division protein FtsQ; Region: FtsQ; pfam03799 932919007038 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 932919007039 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 932919007040 active site 932919007041 homodimer interface [polypeptide binding]; other site 932919007042 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 932919007043 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932919007044 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 932919007045 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 932919007046 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 932919007047 Mg++ binding site [ion binding]; other site 932919007048 putative catalytic motif [active] 932919007049 putative substrate binding site [chemical binding]; other site 932919007050 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 932919007051 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 932919007052 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932919007053 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 932919007054 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 932919007055 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 932919007056 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 932919007057 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 932919007058 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 932919007059 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 932919007060 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 932919007061 MraW methylase family; Region: Methyltransf_5; pfam01795 932919007062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 932919007063 MraZ protein; Region: MraZ; pfam02381 932919007064 MraZ protein; Region: MraZ; pfam02381 932919007065 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932919007066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919007067 putative substrate translocation pore; other site 932919007068 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 932919007069 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 932919007070 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 932919007071 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 932919007072 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 932919007073 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 932919007074 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 932919007075 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 932919007076 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 932919007077 hypothetical protein; Provisional; Region: PRK13670 932919007078 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 932919007079 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 932919007080 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 932919007081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919007082 Walker A/P-loop; other site 932919007083 ATP binding site [chemical binding]; other site 932919007084 Q-loop/lid; other site 932919007085 ABC transporter signature motif; other site 932919007086 Walker B; other site 932919007087 D-loop; other site 932919007088 H-loop/switch region; other site 932919007089 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 932919007090 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 932919007091 protein binding site [polypeptide binding]; other site 932919007092 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 932919007093 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 932919007094 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 932919007095 active site 932919007096 (T/H)XGH motif; other site 932919007097 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 932919007098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919007099 S-adenosylmethionine binding site [chemical binding]; other site 932919007100 hypothetical protein; Provisional; Region: PRK02886 932919007101 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 932919007102 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 932919007103 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 932919007104 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 932919007105 UbiA prenyltransferase family; Region: UbiA; pfam01040 932919007106 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 932919007107 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 932919007108 Ion transport protein; Region: Ion_trans; pfam00520 932919007109 Ion channel; Region: Ion_trans_2; pfam07885 932919007110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 932919007111 MOSC domain; Region: MOSC; pfam03473 932919007112 3-alpha domain; Region: 3-alpha; pfam03475 932919007113 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 932919007114 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 932919007115 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 932919007116 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 932919007117 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 932919007118 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 932919007119 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 932919007120 active site 932919007121 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 932919007122 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 932919007123 ring oligomerisation interface [polypeptide binding]; other site 932919007124 ATP/Mg binding site [chemical binding]; other site 932919007125 stacking interactions; other site 932919007126 hinge regions; other site 932919007127 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 932919007128 oligomerisation interface [polypeptide binding]; other site 932919007129 mobile loop; other site 932919007130 roof hairpin; other site 932919007131 CAAX protease self-immunity; Region: Abi; pfam02517 932919007132 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 932919007133 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 932919007134 CoA binding domain; Region: CoA_binding; pfam02629 932919007135 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 932919007136 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932919007137 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932919007138 ABC transporter; Region: ABC_tran_2; pfam12848 932919007139 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932919007140 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 932919007141 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 932919007142 UGMP family protein; Validated; Region: PRK09604 932919007143 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 932919007144 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 932919007145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919007146 Coenzyme A binding pocket [chemical binding]; other site 932919007147 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 932919007148 Glycoprotease family; Region: Peptidase_M22; pfam00814 932919007149 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 932919007150 camphor resistance protein CrcB; Provisional; Region: PRK14214 932919007151 camphor resistance protein CrcB; Provisional; Region: PRK14231 932919007152 Uncharacterized conserved protein [Function unknown]; Region: COG4832 932919007153 Phosphotransferase enzyme family; Region: APH; pfam01636 932919007154 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 932919007155 active site 932919007156 substrate binding site [chemical binding]; other site 932919007157 ATP binding site [chemical binding]; other site 932919007158 Cna protein B-type domain; Region: Cna_B; pfam05738 932919007159 Cna protein B-type domain; Region: Cna_B; pfam05738 932919007160 Cna protein B-type domain; Region: Cna_B; pfam05738 932919007161 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919007162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919007163 non-specific DNA binding site [nucleotide binding]; other site 932919007164 salt bridge; other site 932919007165 sequence-specific DNA binding site [nucleotide binding]; other site 932919007166 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 932919007167 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 932919007168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932919007169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932919007170 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 932919007171 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 932919007172 substrate binding pocket [chemical binding]; other site 932919007173 argininosuccinate synthase; Provisional; Region: PRK13820 932919007174 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 932919007175 ANP binding site [chemical binding]; other site 932919007176 Substrate Binding Site II [chemical binding]; other site 932919007177 Substrate Binding Site I [chemical binding]; other site 932919007178 argininosuccinate lyase; Provisional; Region: PRK00855 932919007179 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 932919007180 active sites [active] 932919007181 tetramer interface [polypeptide binding]; other site 932919007182 BCCT family transporter; Region: BCCT; pfam02028 932919007183 hypothetical protein; Provisional; Region: PRK06357 932919007184 active site 932919007185 intersubunit interface [polypeptide binding]; other site 932919007186 Zn2+ binding site [ion binding]; other site 932919007187 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 932919007188 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 932919007189 putative substrate binding site [chemical binding]; other site 932919007190 putative ATP binding site [chemical binding]; other site 932919007191 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 932919007192 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 932919007193 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 932919007194 active site 932919007195 P-loop; other site 932919007196 phosphorylation site [posttranslational modification] 932919007197 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919007198 active site 932919007199 phosphorylation site [posttranslational modification] 932919007200 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932919007201 PRD domain; Region: PRD; pfam00874 932919007202 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932919007203 active site 932919007204 P-loop; other site 932919007205 phosphorylation site [posttranslational modification] 932919007206 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 932919007207 active site 932919007208 phosphorylation site [posttranslational modification] 932919007209 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 932919007210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919007211 DNA-binding site [nucleotide binding]; DNA binding site 932919007212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932919007213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919007214 homodimer interface [polypeptide binding]; other site 932919007215 catalytic residue [active] 932919007216 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 932919007217 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 932919007218 active site 932919007219 multimer interface [polypeptide binding]; other site 932919007220 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 932919007221 predicted active site [active] 932919007222 catalytic triad [active] 932919007223 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 932919007224 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 932919007225 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 932919007226 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 932919007227 G1 box; other site 932919007228 GTP/Mg2+ binding site [chemical binding]; other site 932919007229 Switch I region; other site 932919007230 G2 box; other site 932919007231 G3 box; other site 932919007232 Switch II region; other site 932919007233 G4 box; other site 932919007234 G5 box; other site 932919007235 Nucleoside recognition; Region: Gate; pfam07670 932919007236 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 932919007237 Nucleoside recognition; Region: Gate; pfam07670 932919007238 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 932919007239 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 932919007240 putative active site [active] 932919007241 putative metal binding site [ion binding]; other site 932919007242 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932919007243 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 932919007244 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932919007245 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 932919007246 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 932919007247 active site 932919007248 dimer interface [polypeptide binding]; other site 932919007249 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 932919007250 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 932919007251 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 932919007252 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 932919007253 dimer interface [polypeptide binding]; other site 932919007254 FMN binding site [chemical binding]; other site 932919007255 NADPH bind site [chemical binding]; other site 932919007256 Helix-turn-helix domain; Region: HTH_17; pfam12728 932919007257 putative heme peroxidase; Provisional; Region: PRK12276 932919007258 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932919007259 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932919007260 Walker A/P-loop; other site 932919007261 ATP binding site [chemical binding]; other site 932919007262 Q-loop/lid; other site 932919007263 ABC transporter signature motif; other site 932919007264 Walker B; other site 932919007265 D-loop; other site 932919007266 H-loop/switch region; other site 932919007267 FtsX-like permease family; Region: FtsX; pfam02687 932919007268 FtsX-like permease family; Region: FtsX; pfam02687 932919007269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919007270 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932919007271 Coenzyme A binding pocket [chemical binding]; other site 932919007272 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 932919007273 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 932919007274 active site 932919007275 substrate binding site [chemical binding]; other site 932919007276 metal binding site [ion binding]; metal-binding site 932919007277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 932919007278 YbbR-like protein; Region: YbbR; pfam07949 932919007279 YbbR-like protein; Region: YbbR; pfam07949 932919007280 YbbR-like protein; Region: YbbR; pfam07949 932919007281 Uncharacterized conserved protein [Function unknown]; Region: COG1624 932919007282 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 932919007283 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 932919007284 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 932919007285 Predicted integral membrane protein [Function unknown]; Region: COG5521 932919007286 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932919007287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919007288 dimer interface [polypeptide binding]; other site 932919007289 conserved gate region; other site 932919007290 putative PBP binding loops; other site 932919007291 ABC-ATPase subunit interface; other site 932919007292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919007293 dimer interface [polypeptide binding]; other site 932919007294 conserved gate region; other site 932919007295 putative PBP binding loops; other site 932919007296 ABC-ATPase subunit interface; other site 932919007297 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 932919007298 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932919007299 maltodextrin glucosidase; Provisional; Region: PRK10785 932919007300 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 932919007301 homodimer interface [polypeptide binding]; other site 932919007302 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 932919007303 active site 932919007304 homodimer interface [polypeptide binding]; other site 932919007305 catalytic site [active] 932919007306 CAAX protease self-immunity; Region: Abi; cl00558 932919007307 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 932919007308 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 932919007309 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 932919007310 ligand binding site [chemical binding]; other site 932919007311 dimerization interface [polypeptide binding]; other site 932919007312 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932919007313 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932919007314 DNA binding site [nucleotide binding] 932919007315 Amino acid permease; Region: AA_permease_2; pfam13520 932919007316 K+ potassium transporter; Region: K_trans; cl15781 932919007317 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919007318 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932919007319 ligand binding site [chemical binding]; other site 932919007320 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919007321 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932919007322 ligand binding site [chemical binding]; other site 932919007323 flexible hinge region; other site 932919007324 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 932919007325 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 932919007326 intersubunit interface [polypeptide binding]; other site 932919007327 active site 932919007328 zinc binding site [ion binding]; other site 932919007329 Na+ binding site [ion binding]; other site 932919007330 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 932919007331 intersubunit interface [polypeptide binding]; other site 932919007332 active site 932919007333 zinc binding site [ion binding]; other site 932919007334 Na+ binding site [ion binding]; other site 932919007335 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 932919007336 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932919007337 active site 932919007338 P-loop; other site 932919007339 phosphorylation site [posttranslational modification] 932919007340 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919007341 active site 932919007342 phosphorylation site [posttranslational modification] 932919007343 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932919007344 HTH domain; Region: HTH_11; pfam08279 932919007345 Mga helix-turn-helix domain; Region: Mga; pfam05043 932919007346 PRD domain; Region: PRD; pfam00874 932919007347 PRD domain; Region: PRD; pfam00874 932919007348 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932919007349 active site 932919007350 P-loop; other site 932919007351 phosphorylation site [posttranslational modification] 932919007352 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 932919007353 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919007354 Walker A/P-loop; other site 932919007355 ATP binding site [chemical binding]; other site 932919007356 Q-loop/lid; other site 932919007357 ABC transporter signature motif; other site 932919007358 Walker B; other site 932919007359 D-loop; other site 932919007360 H-loop/switch region; other site 932919007361 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 932919007362 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 932919007363 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 932919007364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919007365 Coenzyme A binding pocket [chemical binding]; other site 932919007366 Transcriptional regulators [Transcription]; Region: GntR; COG1802 932919007367 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 932919007368 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 932919007369 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932919007370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919007371 DNA-binding site [nucleotide binding]; DNA binding site 932919007372 UTRA domain; Region: UTRA; pfam07702 932919007373 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 932919007374 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 932919007375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932919007376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932919007377 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 932919007378 putative dimerization interface [polypeptide binding]; other site 932919007379 Predicted membrane protein [Function unknown]; Region: COG2855 932919007380 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 932919007381 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 932919007382 putative metal binding site [ion binding]; other site 932919007383 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 932919007384 homodimer interface [polypeptide binding]; other site 932919007385 chemical substrate binding site [chemical binding]; other site 932919007386 oligomer interface [polypeptide binding]; other site 932919007387 metal binding site [ion binding]; metal-binding site 932919007388 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 932919007389 catalytic residues [active] 932919007390 flavodoxin; Provisional; Region: PRK09271 932919007391 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 932919007392 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 932919007393 dimer interface [polypeptide binding]; other site 932919007394 putative radical transfer pathway; other site 932919007395 diiron center [ion binding]; other site 932919007396 tyrosyl radical; other site 932919007397 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 932919007398 Class I ribonucleotide reductase; Region: RNR_I; cd01679 932919007399 active site 932919007400 dimer interface [polypeptide binding]; other site 932919007401 catalytic residues [active] 932919007402 effector binding site; other site 932919007403 R2 peptide binding site; other site 932919007404 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 932919007405 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 932919007406 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 932919007407 SCP-2 sterol transfer family; Region: SCP2; cl01225 932919007408 CsbD-like; Region: CsbD; cl17424 932919007409 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932919007410 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932919007411 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932919007412 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 932919007413 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 932919007414 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 932919007415 conserved cys residue [active] 932919007416 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 932919007417 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932919007418 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932919007419 Cupin; Region: Cupin_1; pfam00190 932919007420 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932919007421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932919007422 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919007423 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919007424 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932919007425 ligand binding site [chemical binding]; other site 932919007426 flexible hinge region; other site 932919007427 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 932919007428 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932919007429 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932919007430 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 932919007431 dimer interface [polypeptide binding]; other site 932919007432 active site 932919007433 metal binding site [ion binding]; metal-binding site 932919007434 glutathione binding site [chemical binding]; other site 932919007435 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 932919007436 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 932919007437 FMN binding site [chemical binding]; other site 932919007438 substrate binding site [chemical binding]; other site 932919007439 putative catalytic residue [active] 932919007440 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 932919007441 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 932919007442 Coenzyme A transferase; Region: CoA_trans; smart00882 932919007443 Coenzyme A transferase; Region: CoA_trans; cl17247 932919007444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919007445 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 932919007446 Walker A motif; other site 932919007447 ATP binding site [chemical binding]; other site 932919007448 Walker B motif; other site 932919007449 arginine finger; other site 932919007450 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 932919007451 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 932919007452 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 932919007453 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932919007454 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932919007455 metal binding site [ion binding]; metal-binding site 932919007456 active site 932919007457 I-site; other site 932919007458 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 932919007459 classical (c) SDRs; Region: SDR_c; cd05233 932919007460 NAD(P) binding site [chemical binding]; other site 932919007461 active site 932919007462 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932919007463 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932919007464 Tic20-like protein; Region: Tic20; pfam09685 932919007465 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 932919007466 Cna protein B-type domain; Region: Cna_B; pfam05738 932919007467 Collagen binding domain; Region: Collagen_bind; pfam05737 932919007468 Cna protein B-type domain; Region: Cna_B; pfam05738 932919007469 Cna protein B-type domain; Region: Cna_B; pfam05738 932919007470 Cna protein B-type domain; Region: Cna_B; pfam05738 932919007471 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919007472 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 932919007473 Cna protein B-type domain; Region: Cna_B; pfam05738 932919007474 Collagen binding domain; Region: Collagen_bind; pfam05737 932919007475 Cna protein B-type domain; Region: Cna_B; pfam05738 932919007476 Cna protein B-type domain; Region: Cna_B; pfam05738 932919007477 Cna protein B-type domain; Region: Cna_B; pfam05738 932919007478 Cna protein B-type domain; Region: Cna_B; pfam05738 932919007479 Cna protein B-type domain; Region: Cna_B; pfam05738 932919007480 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919007481 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919007482 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919007483 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919007484 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919007485 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 932919007486 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 932919007487 active site 932919007488 catalytic site [active] 932919007489 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 932919007490 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 932919007491 Walker A/P-loop; other site 932919007492 ATP binding site [chemical binding]; other site 932919007493 Q-loop/lid; other site 932919007494 ABC transporter signature motif; other site 932919007495 Walker B; other site 932919007496 D-loop; other site 932919007497 H-loop/switch region; other site 932919007498 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 932919007499 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932919007500 ABC-ATPase subunit interface; other site 932919007501 dimer interface [polypeptide binding]; other site 932919007502 putative PBP binding regions; other site 932919007503 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 932919007504 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 932919007505 intersubunit interface [polypeptide binding]; other site 932919007506 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 932919007507 heme-binding site [chemical binding]; other site 932919007508 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 932919007509 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 932919007510 heme-binding site [chemical binding]; other site 932919007511 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 932919007512 heme-binding site [chemical binding]; other site 932919007513 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 932919007514 heme uptake protein IsdC; Region: IsdC; TIGR03656 932919007515 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 932919007516 heme-binding site [chemical binding]; other site 932919007517 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 932919007518 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 932919007519 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 932919007520 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 932919007521 active site 932919007522 Zn binding site [ion binding]; other site 932919007523 Competence protein CoiA-like family; Region: CoiA; cl11541 932919007524 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 932919007525 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 932919007526 ArsC family; Region: ArsC; pfam03960 932919007527 putative catalytic residues [active] 932919007528 thiol/disulfide switch; other site 932919007529 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 932919007530 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932919007531 Walker A/P-loop; other site 932919007532 ATP binding site [chemical binding]; other site 932919007533 Q-loop/lid; other site 932919007534 ABC transporter signature motif; other site 932919007535 Walker B; other site 932919007536 D-loop; other site 932919007537 H-loop/switch region; other site 932919007538 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 932919007539 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 932919007540 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932919007541 Walker A/P-loop; other site 932919007542 ATP binding site [chemical binding]; other site 932919007543 Q-loop/lid; other site 932919007544 ABC transporter signature motif; other site 932919007545 Walker B; other site 932919007546 D-loop; other site 932919007547 H-loop/switch region; other site 932919007548 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 932919007549 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 932919007550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919007551 dimer interface [polypeptide binding]; other site 932919007552 conserved gate region; other site 932919007553 putative PBP binding loops; other site 932919007554 ABC-ATPase subunit interface; other site 932919007555 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 932919007556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919007557 dimer interface [polypeptide binding]; other site 932919007558 conserved gate region; other site 932919007559 putative PBP binding loops; other site 932919007560 ABC-ATPase subunit interface; other site 932919007561 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 932919007562 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 932919007563 peptide binding site [polypeptide binding]; other site 932919007564 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 932919007565 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 932919007566 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 932919007567 active site 932919007568 HIGH motif; other site 932919007569 dimer interface [polypeptide binding]; other site 932919007570 KMSKS motif; other site 932919007571 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 932919007572 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932919007573 MarR family; Region: MarR; pfam01047 932919007574 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 932919007575 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 932919007576 dimer interface [polypeptide binding]; other site 932919007577 active site 932919007578 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 932919007579 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 932919007580 dimer interface [polypeptide binding]; other site 932919007581 active site 932919007582 CoA binding pocket [chemical binding]; other site 932919007583 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 932919007584 SH3-like domain; Region: SH3_8; pfam13457 932919007585 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 932919007586 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932919007587 catalytic core [active] 932919007588 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932919007589 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 932919007590 Clp amino terminal domain; Region: Clp_N; pfam02861 932919007591 Clp amino terminal domain; Region: Clp_N; pfam02861 932919007592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919007593 Walker A motif; other site 932919007594 ATP binding site [chemical binding]; other site 932919007595 Walker B motif; other site 932919007596 arginine finger; other site 932919007597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919007598 Walker A motif; other site 932919007599 ATP binding site [chemical binding]; other site 932919007600 Walker B motif; other site 932919007601 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 932919007602 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 932919007603 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 932919007604 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932919007605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919007606 active site 932919007607 motif I; other site 932919007608 motif II; other site 932919007609 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 932919007610 Predicted acetyltransferase [General function prediction only]; Region: COG3393 932919007611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 932919007612 ferrochelatase; Provisional; Region: PRK12435 932919007613 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 932919007614 C-terminal domain interface [polypeptide binding]; other site 932919007615 active site 932919007616 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 932919007617 active site 932919007618 N-terminal domain interface [polypeptide binding]; other site 932919007619 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 932919007620 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 932919007621 substrate binding site [chemical binding]; other site 932919007622 active site 932919007623 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 932919007624 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 932919007625 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 932919007626 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 932919007627 Walker A/P-loop; other site 932919007628 ATP binding site [chemical binding]; other site 932919007629 Q-loop/lid; other site 932919007630 ABC transporter signature motif; other site 932919007631 Walker B; other site 932919007632 D-loop; other site 932919007633 H-loop/switch region; other site 932919007634 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 932919007635 HIT family signature motif; other site 932919007636 catalytic residue [active] 932919007637 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 932919007638 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 932919007639 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 932919007640 SurA N-terminal domain; Region: SurA_N_3; cl07813 932919007641 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 932919007642 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 932919007643 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 932919007644 generic binding surface II; other site 932919007645 generic binding surface I; other site 932919007646 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932919007647 Zn2+ binding site [ion binding]; other site 932919007648 Mg2+ binding site [ion binding]; other site 932919007649 Uncharacterized conserved protein [Function unknown]; Region: COG4717 932919007650 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 932919007651 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 932919007652 active site 932919007653 metal binding site [ion binding]; metal-binding site 932919007654 DNA binding site [nucleotide binding] 932919007655 hypothetical protein; Provisional; Region: PRK13676 932919007656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 932919007657 fumarate hydratase; Reviewed; Region: fumC; PRK00485 932919007658 Class II fumarases; Region: Fumarase_classII; cd01362 932919007659 active site 932919007660 tetramer interface [polypeptide binding]; other site 932919007661 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 932919007662 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 932919007663 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 932919007664 Walker A/P-loop; other site 932919007665 ATP binding site [chemical binding]; other site 932919007666 Q-loop/lid; other site 932919007667 ABC transporter signature motif; other site 932919007668 Walker B; other site 932919007669 D-loop; other site 932919007670 H-loop/switch region; other site 932919007671 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 932919007672 Transglycosylase; Region: Transgly; pfam00912 932919007673 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 932919007674 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 932919007675 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 932919007676 Low molecular weight phosphatase family; Region: LMWPc; cl00105 932919007677 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 932919007678 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 932919007679 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 932919007680 Domain of unknown function DUF21; Region: DUF21; pfam01595 932919007681 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 932919007682 Transporter associated domain; Region: CorC_HlyC; smart01091 932919007683 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932919007684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932919007685 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 932919007686 putative dimerization interface [polypeptide binding]; other site 932919007687 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 932919007688 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 932919007689 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 932919007690 active site 932919007691 FMN binding site [chemical binding]; other site 932919007692 substrate binding site [chemical binding]; other site 932919007693 putative catalytic residue [active] 932919007694 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932919007695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932919007696 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 932919007697 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 932919007698 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 932919007699 shikimate binding site; other site 932919007700 NAD(P) binding site [chemical binding]; other site 932919007701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919007702 putative substrate translocation pore; other site 932919007703 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932919007704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919007705 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932919007706 putative substrate translocation pore; other site 932919007707 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 932919007708 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 932919007709 Walker A/P-loop; other site 932919007710 ATP binding site [chemical binding]; other site 932919007711 Q-loop/lid; other site 932919007712 ABC transporter signature motif; other site 932919007713 Walker B; other site 932919007714 D-loop; other site 932919007715 H-loop/switch region; other site 932919007716 Predicted transcriptional regulators [Transcription]; Region: COG1725 932919007717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932919007718 DNA-binding site [nucleotide binding]; DNA binding site 932919007719 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 932919007720 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 932919007721 DNA binding site [nucleotide binding] 932919007722 active site 932919007723 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 932919007724 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 932919007725 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932919007726 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932919007727 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 932919007728 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 932919007729 active site 932919007730 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 932919007731 putative dimer interface [polypeptide binding]; other site 932919007732 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932919007733 ligand binding site [chemical binding]; other site 932919007734 Zn binding site [ion binding]; other site 932919007735 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 932919007736 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 932919007737 active site 932919007738 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932919007739 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932919007740 active site 932919007741 catalytic tetrad [active] 932919007742 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 932919007743 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 932919007744 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932919007745 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932919007746 substrate binding pocket [chemical binding]; other site 932919007747 membrane-bound complex binding site; other site 932919007748 hinge residues; other site 932919007749 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932919007750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919007751 dimer interface [polypeptide binding]; other site 932919007752 conserved gate region; other site 932919007753 putative PBP binding loops; other site 932919007754 ABC-ATPase subunit interface; other site 932919007755 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 932919007756 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 932919007757 Walker A/P-loop; other site 932919007758 ATP binding site [chemical binding]; other site 932919007759 Q-loop/lid; other site 932919007760 ABC transporter signature motif; other site 932919007761 Walker B; other site 932919007762 D-loop; other site 932919007763 H-loop/switch region; other site 932919007764 aspartate aminotransferase; Provisional; Region: PRK06348 932919007765 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932919007766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919007767 homodimer interface [polypeptide binding]; other site 932919007768 catalytic residue [active] 932919007769 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 932919007770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919007771 motif II; other site 932919007772 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 932919007773 intracellular protease, PfpI family; Region: PfpI; TIGR01382 932919007774 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 932919007775 proposed catalytic triad [active] 932919007776 conserved cys residue [active] 932919007777 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932919007778 methionine cluster; other site 932919007779 active site 932919007780 phosphorylation site [posttranslational modification] 932919007781 metal binding site [ion binding]; metal-binding site 932919007782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919007783 Coenzyme A binding pocket [chemical binding]; other site 932919007784 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932919007785 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 932919007786 esterase; Provisional; Region: PRK10566 932919007787 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 932919007788 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932919007789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 932919007790 motif II; other site 932919007791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919007792 Uncharacterized conserved protein [Function unknown]; Region: COG1284 932919007793 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 932919007794 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 932919007795 hypothetical protein; Provisional; Region: PRK13673 932919007796 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 932919007797 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 932919007798 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 932919007799 Part of AAA domain; Region: AAA_19; pfam13245 932919007800 Family description; Region: UvrD_C_2; pfam13538 932919007801 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 932919007802 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 932919007803 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 932919007804 IDEAL domain; Region: IDEAL; pfam08858 932919007805 ComK protein; Region: ComK; cl11560 932919007806 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932919007807 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919007808 non-specific DNA binding site [nucleotide binding]; other site 932919007809 salt bridge; other site 932919007810 sequence-specific DNA binding site [nucleotide binding]; other site 932919007811 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 932919007812 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919007813 active site 932919007814 phosphorylation site [posttranslational modification] 932919007815 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932919007816 active site 932919007817 P-loop; other site 932919007818 phosphorylation site [posttranslational modification] 932919007819 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 932919007820 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 932919007821 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 932919007822 putative substrate binding site [chemical binding]; other site 932919007823 putative ATP binding site [chemical binding]; other site 932919007824 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932919007825 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 932919007826 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932919007827 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 932919007828 trimer interface [polypeptide binding]; other site 932919007829 active site 932919007830 G bulge; other site 932919007831 Uncharacterized conserved protein [Function unknown]; Region: COG1683 932919007832 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 932919007833 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 932919007834 non-specific DNA interactions [nucleotide binding]; other site 932919007835 DNA binding site [nucleotide binding] 932919007836 sequence specific DNA binding site [nucleotide binding]; other site 932919007837 putative cAMP binding site [chemical binding]; other site 932919007838 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 932919007839 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932919007840 substrate binding site [chemical binding]; other site 932919007841 ATP binding site [chemical binding]; other site 932919007842 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 932919007843 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932919007844 RNA binding surface [nucleotide binding]; other site 932919007845 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 932919007846 active site 932919007847 uracil binding [chemical binding]; other site 932919007848 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 932919007849 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 932919007850 active site 932919007851 non-prolyl cis peptide bond; other site 932919007852 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 932919007853 catalytic residues [active] 932919007854 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 932919007855 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 932919007856 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 932919007857 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 932919007858 Walker A/P-loop; other site 932919007859 ATP binding site [chemical binding]; other site 932919007860 Q-loop/lid; other site 932919007861 ABC transporter signature motif; other site 932919007862 Walker B; other site 932919007863 D-loop; other site 932919007864 H-loop/switch region; other site 932919007865 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932919007866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919007867 dimer interface [polypeptide binding]; other site 932919007868 conserved gate region; other site 932919007869 putative PBP binding loops; other site 932919007870 ABC-ATPase subunit interface; other site 932919007871 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932919007872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919007873 dimer interface [polypeptide binding]; other site 932919007874 conserved gate region; other site 932919007875 putative PBP binding loops; other site 932919007876 ABC-ATPase subunit interface; other site 932919007877 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932919007878 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932919007879 substrate binding pocket [chemical binding]; other site 932919007880 membrane-bound complex binding site; other site 932919007881 hinge residues; other site 932919007882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919007883 Coenzyme A binding pocket [chemical binding]; other site 932919007884 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 932919007885 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 932919007886 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932919007887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932919007888 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 932919007889 dimerization interface [polypeptide binding]; other site 932919007890 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 932919007891 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 932919007892 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 932919007893 active site 932919007894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919007895 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932919007896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919007897 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 932919007898 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 932919007899 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 932919007900 active site 932919007901 trimer interface [polypeptide binding]; other site 932919007902 allosteric site; other site 932919007903 active site lid [active] 932919007904 hexamer (dimer of trimers) interface [polypeptide binding]; other site 932919007905 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932919007906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 932919007907 Predicted membrane protein [Function unknown]; Region: COG1511 932919007908 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 932919007909 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 932919007910 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 932919007911 Predicted transcriptional regulator [Transcription]; Region: COG1959 932919007912 Transcriptional regulator; Region: Rrf2; pfam02082 932919007913 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 932919007914 L-tyrosine decarboxylase; Provisional; Region: PRK13520 932919007915 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 932919007916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919007917 catalytic residue [active] 932919007918 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 932919007919 Mga helix-turn-helix domain; Region: Mga; pfam05043 932919007920 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 932919007921 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932919007922 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 932919007923 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932919007924 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 932919007925 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 932919007926 active site 932919007927 dimer interface [polypeptide binding]; other site 932919007928 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 932919007929 dimer interface [polypeptide binding]; other site 932919007930 active site 932919007931 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 932919007932 nudix motif; other site 932919007933 general stress protein 13; Validated; Region: PRK08059 932919007934 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 932919007935 RNA binding site [nucleotide binding]; other site 932919007936 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 932919007937 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932919007938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919007939 homodimer interface [polypeptide binding]; other site 932919007940 catalytic residue [active] 932919007941 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 932919007942 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932919007943 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932919007944 Walker A/P-loop; other site 932919007945 ATP binding site [chemical binding]; other site 932919007946 Q-loop/lid; other site 932919007947 ABC transporter signature motif; other site 932919007948 Walker B; other site 932919007949 D-loop; other site 932919007950 H-loop/switch region; other site 932919007951 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932919007952 active site 932919007953 P-loop; other site 932919007954 phosphorylation site [posttranslational modification] 932919007955 aspartate kinase; Reviewed; Region: PRK09034 932919007956 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 932919007957 putative catalytic residues [active] 932919007958 putative nucleotide binding site [chemical binding]; other site 932919007959 putative aspartate binding site [chemical binding]; other site 932919007960 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 932919007961 allosteric regulatory residue; other site 932919007962 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 932919007963 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 932919007964 active site 932919007965 drug efflux system protein MdtG; Provisional; Region: PRK09874 932919007966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919007967 putative substrate translocation pore; other site 932919007968 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 932919007969 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 932919007970 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 932919007971 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 932919007972 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 932919007973 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 932919007974 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 932919007975 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 932919007976 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 932919007977 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 932919007978 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 932919007979 CoenzymeA binding site [chemical binding]; other site 932919007980 subunit interaction site [polypeptide binding]; other site 932919007981 PHB binding site; other site 932919007982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 932919007983 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 932919007984 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 932919007985 Cl- selectivity filter; other site 932919007986 Cl- binding residues [ion binding]; other site 932919007987 pore gating glutamate residue; other site 932919007988 dimer interface [polypeptide binding]; other site 932919007989 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919007990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 932919007991 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 932919007992 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932919007993 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 932919007994 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932919007995 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932919007996 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 932919007997 NADH(P)-binding; Region: NAD_binding_10; pfam13460 932919007998 NAD(P) binding site [chemical binding]; other site 932919007999 putative active site [active] 932919008000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844 932919008001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 932919008002 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932919008003 Leucine-rich repeats; other site 932919008004 Substrate binding site [chemical binding]; other site 932919008005 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919008006 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919008007 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919008008 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919008009 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919008010 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919008011 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919008012 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919008013 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919008014 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 932919008015 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 932919008016 tetramer interfaces [polypeptide binding]; other site 932919008017 binuclear metal-binding site [ion binding]; other site 932919008018 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 932919008019 Domain of unknown function DUF21; Region: DUF21; pfam01595 932919008020 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 932919008021 Transporter associated domain; Region: CorC_HlyC; smart01091 932919008022 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932919008023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919008024 Coenzyme A binding pocket [chemical binding]; other site 932919008025 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 932919008026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919008027 active site 932919008028 motif I; other site 932919008029 motif II; other site 932919008030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919008031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 932919008032 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 932919008033 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 932919008034 active site 932919008035 metal binding site [ion binding]; metal-binding site 932919008036 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 932919008037 Predicted permeases [General function prediction only]; Region: COG0730 932919008038 Predicted membrane protein [Function unknown]; Region: COG4272 932919008039 Uncharacterized conserved protein [Function unknown]; Region: COG1801 932919008040 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 932919008041 FeS assembly protein SufB; Region: sufB; TIGR01980 932919008042 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 932919008043 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 932919008044 trimerization site [polypeptide binding]; other site 932919008045 active site 932919008046 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 932919008047 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 932919008048 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932919008049 catalytic residue [active] 932919008050 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 932919008051 FeS assembly protein SufD; Region: sufD; TIGR01981 932919008052 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 932919008053 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 932919008054 Walker A/P-loop; other site 932919008055 ATP binding site [chemical binding]; other site 932919008056 Q-loop/lid; other site 932919008057 ABC transporter signature motif; other site 932919008058 Walker B; other site 932919008059 D-loop; other site 932919008060 H-loop/switch region; other site 932919008061 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 932919008062 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 932919008063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919008064 ABC-ATPase subunit interface; other site 932919008065 putative PBP binding loops; other site 932919008066 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 932919008067 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 932919008068 Walker A/P-loop; other site 932919008069 ATP binding site [chemical binding]; other site 932919008070 Q-loop/lid; other site 932919008071 ABC transporter signature motif; other site 932919008072 Walker B; other site 932919008073 D-loop; other site 932919008074 H-loop/switch region; other site 932919008075 NIL domain; Region: NIL; pfam09383 932919008076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932919008077 dimer interface [polypeptide binding]; other site 932919008078 phosphorylation site [posttranslational modification] 932919008079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919008080 ATP binding site [chemical binding]; other site 932919008081 Mg2+ binding site [ion binding]; other site 932919008082 G-X-G motif; other site 932919008083 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932919008084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919008085 active site 932919008086 phosphorylation site [posttranslational modification] 932919008087 intermolecular recognition site; other site 932919008088 dimerization interface [polypeptide binding]; other site 932919008089 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932919008090 DNA binding site [nucleotide binding] 932919008091 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 932919008092 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 932919008093 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 932919008094 catalytic residues [active] 932919008095 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 932919008096 lipoyl attachment site [posttranslational modification]; other site 932919008097 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 932919008098 ArsC family; Region: ArsC; pfam03960 932919008099 putative ArsC-like catalytic residues; other site 932919008100 putative TRX-like catalytic residues [active] 932919008101 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 932919008102 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 932919008103 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 932919008104 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 932919008105 Walker A/P-loop; other site 932919008106 ATP binding site [chemical binding]; other site 932919008107 Q-loop/lid; other site 932919008108 ABC transporter signature motif; other site 932919008109 Walker B; other site 932919008110 D-loop; other site 932919008111 H-loop/switch region; other site 932919008112 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 932919008113 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932919008114 ABC-ATPase subunit interface; other site 932919008115 dimer interface [polypeptide binding]; other site 932919008116 putative PBP binding regions; other site 932919008117 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 932919008118 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 932919008119 intersubunit interface [polypeptide binding]; other site 932919008120 Predicted esterase [General function prediction only]; Region: COG0627 932919008121 S-formylglutathione hydrolase; Region: PLN02442 932919008122 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 932919008123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919008124 catalytic residue [active] 932919008125 SdpI/YhfL protein family; Region: SdpI; pfam13630 932919008126 CAT RNA binding domain; Region: CAT_RBD; smart01061 932919008127 transcriptional antiterminator BglG; Provisional; Region: PRK09772 932919008128 PRD domain; Region: PRD; pfam00874 932919008129 PRD domain; Region: PRD; pfam00874 932919008130 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 932919008131 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 932919008132 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 932919008133 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 932919008134 Predicted transcriptional regulator [Transcription]; Region: COG2378 932919008135 HTH domain; Region: HTH_11; pfam08279 932919008136 WYL domain; Region: WYL; pfam13280 932919008137 Uncharacterized conserved protein [Function unknown]; Region: COG1434 932919008138 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 932919008139 putative active site [active] 932919008140 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932919008141 Leucine rich repeat; Region: LRR_8; pfam13855 932919008142 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 932919008143 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 932919008144 active site 932919008145 catalytic site [active] 932919008146 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 932919008147 putative metal binding site [ion binding]; other site 932919008148 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 932919008149 putative metal binding site [ion binding]; other site 932919008150 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932919008151 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 932919008152 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 932919008153 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 932919008154 active site 932919008155 catalytic site [active] 932919008156 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 932919008157 putative metal binding site [ion binding]; other site 932919008158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919008159 non-specific DNA binding site [nucleotide binding]; other site 932919008160 salt bridge; other site 932919008161 sequence-specific DNA binding site [nucleotide binding]; other site 932919008162 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 932919008163 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 932919008164 SmpB-tmRNA interface; other site 932919008165 ribonuclease R; Region: RNase_R; TIGR02063 932919008166 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 932919008167 RNB domain; Region: RNB; pfam00773 932919008168 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 932919008169 RNA binding site [nucleotide binding]; other site 932919008170 Esterase/lipase [General function prediction only]; Region: COG1647 932919008171 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 932919008172 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 932919008173 Preprotein translocase SecG subunit; Region: SecG; cl09123 932919008174 Esterase/lipase [General function prediction only]; Region: COG1647 932919008175 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 932919008176 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 932919008177 PGAP1-like protein; Region: PGAP1; pfam07819 932919008178 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 932919008179 enolase; Provisional; Region: eno; PRK00077 932919008180 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 932919008181 dimer interface [polypeptide binding]; other site 932919008182 metal binding site [ion binding]; metal-binding site 932919008183 substrate binding pocket [chemical binding]; other site 932919008184 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 932919008185 phosphoglyceromutase; Provisional; Region: PRK05434 932919008186 triosephosphate isomerase; Provisional; Region: PRK14567 932919008187 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 932919008188 substrate binding site [chemical binding]; other site 932919008189 dimer interface [polypeptide binding]; other site 932919008190 catalytic triad [active] 932919008191 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 932919008192 Phosphoglycerate kinase; Region: PGK; pfam00162 932919008193 substrate binding site [chemical binding]; other site 932919008194 hinge regions; other site 932919008195 ADP binding site [chemical binding]; other site 932919008196 catalytic site [active] 932919008197 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 932919008198 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 932919008199 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 932919008200 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 932919008201 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 932919008202 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 932919008203 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 932919008204 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 932919008205 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932919008206 DNA binding site [nucleotide binding] 932919008207 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 932919008208 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 932919008209 active site 932919008210 dimer interface [polypeptide binding]; other site 932919008211 MMPL family; Region: MMPL; pfam03176 932919008212 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 932919008213 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932919008214 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932919008215 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 932919008216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 932919008217 Chitin binding domain; Region: Chitin_bind_3; pfam03067 932919008218 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 932919008219 Interdomain contacts; other site 932919008220 Cytokine receptor motif; other site 932919008221 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 932919008222 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 932919008223 Interdomain contacts; other site 932919008224 Cytokine receptor motif; other site 932919008225 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 932919008226 aromatic chitin/cellulose binding site residues [chemical binding]; other site 932919008227 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 932919008228 aromatic chitin/cellulose binding site residues [chemical binding]; other site 932919008229 Clp protease; Region: CLP_protease; pfam00574 932919008230 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 932919008231 oligomer interface [polypeptide binding]; other site 932919008232 active site residues [active] 932919008233 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 932919008234 amino acid transporter; Region: 2A0306; TIGR00909 932919008235 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 932919008236 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932919008237 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919008238 Substrate binding site [chemical binding]; other site 932919008239 Leucine rich repeat; Region: LRR_8; pfam13855 932919008240 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919008241 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 932919008242 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 932919008243 active site 932919008244 FMN binding site [chemical binding]; other site 932919008245 substrate binding site [chemical binding]; other site 932919008246 homotetramer interface [polypeptide binding]; other site 932919008247 catalytic residue [active] 932919008248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 932919008249 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 932919008250 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 932919008251 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 932919008252 phosphate binding site [ion binding]; other site 932919008253 putative substrate binding pocket [chemical binding]; other site 932919008254 dimer interface [polypeptide binding]; other site 932919008255 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 932919008256 AAA domain; Region: AAA_18; pfam13238 932919008257 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 932919008258 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 932919008259 active site 932919008260 substrate binding site [chemical binding]; other site 932919008261 metal binding site [ion binding]; metal-binding site 932919008262 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 932919008263 active site 932919008264 catalytic residues [active] 932919008265 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 932919008266 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 932919008267 NAD binding site [chemical binding]; other site 932919008268 homodimer interface [polypeptide binding]; other site 932919008269 active site 932919008270 substrate binding site [chemical binding]; other site 932919008271 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 932919008272 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932919008273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932919008274 TPR repeat; Region: TPR_11; pfam13414 932919008275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932919008276 binding surface 932919008277 TPR motif; other site 932919008278 Tetratricopeptide repeat; Region: TPR_12; pfam13424 932919008279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932919008280 binding surface 932919008281 TPR motif; other site 932919008282 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 932919008283 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 932919008284 putative trimer interface [polypeptide binding]; other site 932919008285 putative CoA binding site [chemical binding]; other site 932919008286 pyrophosphatase PpaX; Provisional; Region: PRK13288 932919008287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919008288 motif II; other site 932919008289 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 932919008290 HPr kinase/phosphorylase; Provisional; Region: PRK05428 932919008291 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 932919008292 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 932919008293 Hpr binding site; other site 932919008294 active site 932919008295 homohexamer subunit interaction site [polypeptide binding]; other site 932919008296 Predicted membrane protein [Function unknown]; Region: COG1950 932919008297 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 932919008298 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 932919008299 Uncharacterized conserved protein [Function unknown]; Region: COG3595 932919008300 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 932919008301 Uncharacterized conserved protein [Function unknown]; Region: COG3595 932919008302 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 932919008303 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 932919008304 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 932919008305 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 932919008306 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 932919008307 excinuclease ABC subunit B; Provisional; Region: PRK05298 932919008308 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932919008309 ATP binding site [chemical binding]; other site 932919008310 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932919008311 nucleotide binding region [chemical binding]; other site 932919008312 ATP-binding site [chemical binding]; other site 932919008313 Ultra-violet resistance protein B; Region: UvrB; pfam12344 932919008314 UvrB/uvrC motif; Region: UVR; pfam02151 932919008315 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 932919008316 HD containing hydrolase-like enzyme; Region: HD_2; pfam12917 932919008317 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932919008318 dimerization interface [polypeptide binding]; other site 932919008319 putative DNA binding site [nucleotide binding]; other site 932919008320 putative Zn2+ binding site [ion binding]; other site 932919008321 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 932919008322 PhoU domain; Region: PhoU; pfam01895 932919008323 PhoU domain; Region: PhoU; pfam01895 932919008324 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 932919008325 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 932919008326 Walker A/P-loop; other site 932919008327 ATP binding site [chemical binding]; other site 932919008328 Q-loop/lid; other site 932919008329 ABC transporter signature motif; other site 932919008330 Walker B; other site 932919008331 D-loop; other site 932919008332 H-loop/switch region; other site 932919008333 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 932919008334 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 932919008335 Walker A/P-loop; other site 932919008336 ATP binding site [chemical binding]; other site 932919008337 Q-loop/lid; other site 932919008338 ABC transporter signature motif; other site 932919008339 Walker B; other site 932919008340 D-loop; other site 932919008341 H-loop/switch region; other site 932919008342 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 932919008343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919008344 dimer interface [polypeptide binding]; other site 932919008345 conserved gate region; other site 932919008346 putative PBP binding loops; other site 932919008347 ABC-ATPase subunit interface; other site 932919008348 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 932919008349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919008350 dimer interface [polypeptide binding]; other site 932919008351 conserved gate region; other site 932919008352 putative PBP binding loops; other site 932919008353 ABC-ATPase subunit interface; other site 932919008354 PBP superfamily domain; Region: PBP_like_2; cl17296 932919008355 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 932919008356 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 932919008357 HAMP domain; Region: HAMP; pfam00672 932919008358 dimerization interface [polypeptide binding]; other site 932919008359 PAS domain; Region: PAS; smart00091 932919008360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932919008361 dimer interface [polypeptide binding]; other site 932919008362 phosphorylation site [posttranslational modification] 932919008363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919008364 ATP binding site [chemical binding]; other site 932919008365 Mg2+ binding site [ion binding]; other site 932919008366 G-X-G motif; other site 932919008367 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932919008368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919008369 active site 932919008370 phosphorylation site [posttranslational modification] 932919008371 intermolecular recognition site; other site 932919008372 dimerization interface [polypeptide binding]; other site 932919008373 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932919008374 DNA binding site [nucleotide binding] 932919008375 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 932919008376 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 932919008377 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 932919008378 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 932919008379 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 932919008380 putative active site [active] 932919008381 catalytic site [active] 932919008382 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 932919008383 putative active site [active] 932919008384 catalytic site [active] 932919008385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 932919008386 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 932919008387 Peptidase family M23; Region: Peptidase_M23; pfam01551 932919008388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 932919008389 NlpC/P60 family; Region: NLPC_P60; pfam00877 932919008390 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 932919008391 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 932919008392 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 932919008393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919008394 Walker A/P-loop; other site 932919008395 ATP binding site [chemical binding]; other site 932919008396 Q-loop/lid; other site 932919008397 ABC transporter signature motif; other site 932919008398 Walker B; other site 932919008399 D-loop; other site 932919008400 H-loop/switch region; other site 932919008401 Uncharacterized conserved protein [Function unknown]; Region: COG1284 932919008402 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 932919008403 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 932919008404 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 932919008405 peptide chain release factor 2; Validated; Region: prfB; PRK00578 932919008406 This domain is found in peptide chain release factors; Region: PCRF; smart00937 932919008407 RF-1 domain; Region: RF-1; pfam00472 932919008408 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 932919008409 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 932919008410 nucleotide binding region [chemical binding]; other site 932919008411 helicase superfamily c-terminal domain; Region: HELICc; smart00490 932919008412 ATP-binding site [chemical binding]; other site 932919008413 SEC-C motif; Region: SEC-C; pfam02810 932919008414 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 932919008415 30S subunit binding site; other site 932919008416 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 932919008417 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932919008418 active site 932919008419 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 932919008420 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932919008421 ATP binding site [chemical binding]; other site 932919008422 putative Mg++ binding site [ion binding]; other site 932919008423 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932919008424 nucleotide binding region [chemical binding]; other site 932919008425 ATP-binding site [chemical binding]; other site 932919008426 EDD domain protein, DegV family; Region: DegV; TIGR00762 932919008427 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 932919008428 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 932919008429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919008430 active site 932919008431 phosphorylation site [posttranslational modification] 932919008432 intermolecular recognition site; other site 932919008433 dimerization interface [polypeptide binding]; other site 932919008434 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 932919008435 DNA binding residues [nucleotide binding] 932919008436 dimerization interface [polypeptide binding]; other site 932919008437 Uncharacterized conserved protein [Function unknown]; Region: COG1739 932919008438 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 932919008439 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 932919008440 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932919008441 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932919008442 Transcriptional regulator [Transcription]; Region: LytR; COG1316 932919008443 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 932919008444 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 932919008445 Mg++ binding site [ion binding]; other site 932919008446 putative catalytic motif [active] 932919008447 substrate binding site [chemical binding]; other site 932919008448 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 932919008449 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 932919008450 active site 932919008451 octamer interface [polypeptide binding]; other site 932919008452 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 932919008453 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 932919008454 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932919008455 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932919008456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 932919008457 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 932919008458 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 932919008459 dimer interface [polypeptide binding]; other site 932919008460 ssDNA binding site [nucleotide binding]; other site 932919008461 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932919008462 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 932919008463 rod shape-determining protein Mbl; Provisional; Region: PRK13928 932919008464 MreB and similar proteins; Region: MreB_like; cd10225 932919008465 nucleotide binding site [chemical binding]; other site 932919008466 Mg binding site [ion binding]; other site 932919008467 putative protofilament interaction site [polypeptide binding]; other site 932919008468 RodZ interaction site [polypeptide binding]; other site 932919008469 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 932919008470 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 932919008471 hinge; other site 932919008472 active site 932919008473 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 932919008474 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 932919008475 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 932919008476 gamma subunit interface [polypeptide binding]; other site 932919008477 epsilon subunit interface [polypeptide binding]; other site 932919008478 LBP interface [polypeptide binding]; other site 932919008479 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 932919008480 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 932919008481 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 932919008482 alpha subunit interaction interface [polypeptide binding]; other site 932919008483 Walker A motif; other site 932919008484 ATP binding site [chemical binding]; other site 932919008485 Walker B motif; other site 932919008486 inhibitor binding site; inhibition site 932919008487 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 932919008488 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 932919008489 core domain interface [polypeptide binding]; other site 932919008490 delta subunit interface [polypeptide binding]; other site 932919008491 epsilon subunit interface [polypeptide binding]; other site 932919008492 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 932919008493 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 932919008494 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 932919008495 beta subunit interaction interface [polypeptide binding]; other site 932919008496 Walker A motif; other site 932919008497 ATP binding site [chemical binding]; other site 932919008498 Walker B motif; other site 932919008499 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 932919008500 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 932919008501 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 932919008502 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 932919008503 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 932919008504 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 932919008505 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 932919008506 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 932919008507 ATP synthase I chain; Region: ATP_synt_I; pfam03899 932919008508 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 932919008509 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 932919008510 active site 932919008511 homodimer interface [polypeptide binding]; other site 932919008512 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932919008513 active site 932919008514 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 932919008515 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 932919008516 dimer interface [polypeptide binding]; other site 932919008517 active site 932919008518 glycine-pyridoxal phosphate binding site [chemical binding]; other site 932919008519 folate binding site [chemical binding]; other site 932919008520 Low molecular weight phosphatase family; Region: LMWPc; cd00115 932919008521 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 932919008522 active site 932919008523 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 932919008524 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 932919008525 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 932919008526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919008527 S-adenosylmethionine binding site [chemical binding]; other site 932919008528 peptide chain release factor 1; Validated; Region: prfA; PRK00591 932919008529 This domain is found in peptide chain release factors; Region: PCRF; smart00937 932919008530 RF-1 domain; Region: RF-1; pfam00472 932919008531 thymidine kinase; Provisional; Region: PRK04296 932919008532 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 932919008533 ATP binding site [chemical binding]; other site 932919008534 Walker A motif; other site 932919008535 Walker B motif; other site 932919008536 homoserine kinase; Provisional; Region: PRK01212 932919008537 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 932919008538 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 932919008539 threonine synthase; Reviewed; Region: PRK06721 932919008540 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 932919008541 homodimer interface [polypeptide binding]; other site 932919008542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919008543 catalytic residue [active] 932919008544 homoserine dehydrogenase; Provisional; Region: PRK06349 932919008545 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 932919008546 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 932919008547 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 932919008548 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 932919008549 Predicted membrane protein [Function unknown]; Region: COG2246 932919008550 GtrA-like protein; Region: GtrA; pfam04138 932919008551 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 932919008552 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 932919008553 Ligand binding site; other site 932919008554 Putative Catalytic site; other site 932919008555 DXD motif; other site 932919008556 transcription termination factor Rho; Provisional; Region: rho; PRK09376 932919008557 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 932919008558 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 932919008559 RNA binding site [nucleotide binding]; other site 932919008560 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 932919008561 multimer interface [polypeptide binding]; other site 932919008562 Walker A motif; other site 932919008563 ATP binding site [chemical binding]; other site 932919008564 Walker B motif; other site 932919008565 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 932919008566 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 932919008567 hinge; other site 932919008568 active site 932919008569 Predicted integral membrane protein [Function unknown]; Region: COG0392 932919008570 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 932919008571 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 932919008572 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 932919008573 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 932919008574 putative ADP-binding pocket [chemical binding]; other site 932919008575 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 932919008576 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 932919008577 intersubunit interface [polypeptide binding]; other site 932919008578 active site 932919008579 zinc binding site [ion binding]; other site 932919008580 Na+ binding site [ion binding]; other site 932919008581 putative lipid kinase; Reviewed; Region: PRK13055 932919008582 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 932919008583 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 932919008584 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 932919008585 amidase catalytic site [active] 932919008586 Zn binding residues [ion binding]; other site 932919008587 substrate binding site [chemical binding]; other site 932919008588 SH3-like domain; Region: SH3_8; pfam13457 932919008589 SH3-like domain; Region: SH3_8; pfam13457 932919008590 SH3-like domain; Region: SH3_8; pfam13457 932919008591 SH3-like domain; Region: SH3_8; pfam13457 932919008592 CTP synthetase; Validated; Region: pyrG; PRK05380 932919008593 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 932919008594 Catalytic site [active] 932919008595 active site 932919008596 UTP binding site [chemical binding]; other site 932919008597 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 932919008598 active site 932919008599 putative oxyanion hole; other site 932919008600 catalytic triad [active] 932919008601 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 932919008602 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 932919008603 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 932919008604 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 932919008605 active site 932919008606 HIGH motif; other site 932919008607 KMSK motif region; other site 932919008608 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 932919008609 tRNA binding surface [nucleotide binding]; other site 932919008610 anticodon binding site; other site 932919008611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 932919008612 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 932919008613 Peptidase family M50; Region: Peptidase_M50; pfam02163 932919008614 active site 932919008615 putative substrate binding region [chemical binding]; other site 932919008616 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 932919008617 active site 1 [active] 932919008618 dimer interface [polypeptide binding]; other site 932919008619 hexamer interface [polypeptide binding]; other site 932919008620 active site 2 [active] 932919008621 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 932919008622 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932919008623 Zn2+ binding site [ion binding]; other site 932919008624 Mg2+ binding site [ion binding]; other site 932919008625 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 932919008626 conserved hypothetical protein TIGR01655; Region: yxeA_fam 932919008627 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 932919008628 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 932919008629 peptide binding site [polypeptide binding]; other site 932919008630 Predicted integral membrane protein [Function unknown]; Region: COG5658 932919008631 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 932919008632 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 932919008633 catalytic triad [active] 932919008634 metal binding site [ion binding]; metal-binding site 932919008635 conserved cis-peptide bond; other site 932919008636 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 932919008637 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 932919008638 folate binding site [chemical binding]; other site 932919008639 NADP+ binding site [chemical binding]; other site 932919008640 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 932919008641 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 932919008642 putative NAD(P) binding site [chemical binding]; other site 932919008643 dimer interface [polypeptide binding]; other site 932919008644 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 932919008645 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 932919008646 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932919008647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919008648 active site 932919008649 motif I; other site 932919008650 motif II; other site 932919008651 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 932919008652 Uncharacterized conserved protein [Function unknown]; Region: COG1359 932919008653 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932919008654 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932919008655 Walker A/P-loop; other site 932919008656 ATP binding site [chemical binding]; other site 932919008657 Q-loop/lid; other site 932919008658 ABC transporter signature motif; other site 932919008659 Walker B; other site 932919008660 D-loop; other site 932919008661 H-loop/switch region; other site 932919008662 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932919008663 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 932919008664 FtsX-like permease family; Region: FtsX; pfam02687 932919008665 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932919008666 dimerization interface [polypeptide binding]; other site 932919008667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932919008668 dimer interface [polypeptide binding]; other site 932919008669 phosphorylation site [posttranslational modification] 932919008670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919008671 ATP binding site [chemical binding]; other site 932919008672 Mg2+ binding site [ion binding]; other site 932919008673 G-X-G motif; other site 932919008674 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932919008675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919008676 active site 932919008677 phosphorylation site [posttranslational modification] 932919008678 intermolecular recognition site; other site 932919008679 dimerization interface [polypeptide binding]; other site 932919008680 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932919008681 DNA binding site [nucleotide binding] 932919008682 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 932919008683 Uncharacterized conserved protein [Function unknown]; Region: COG2427 932919008684 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 932919008685 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 932919008686 catalytic loop [active] 932919008687 iron binding site [ion binding]; other site 932919008688 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 932919008689 4Fe-4S binding domain; Region: Fer4; pfam00037 932919008690 4Fe-4S binding domain; Region: Fer4; pfam00037 932919008691 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 932919008692 [4Fe-4S] binding site [ion binding]; other site 932919008693 molybdopterin cofactor binding site; other site 932919008694 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 932919008695 molybdopterin cofactor binding site; other site 932919008696 Uncharacterized conserved protein [Function unknown]; Region: COG1912 932919008697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919008698 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932919008699 putative substrate translocation pore; other site 932919008700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932919008701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932919008702 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 932919008703 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 932919008704 Walker A motif; other site 932919008705 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 932919008706 SH3-like domain; Region: SH3_8; pfam13457 932919008707 SH3-like domain; Region: SH3_8; pfam13457 932919008708 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932919008709 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932919008710 active site 932919008711 catalytic tetrad [active] 932919008712 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 932919008713 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 932919008714 DNA binding residues [nucleotide binding] 932919008715 putative dimer interface [polypeptide binding]; other site 932919008716 CRISPR/Cas system-associated protein Csn2; Region: Csn2_like; cl09913 932919008717 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 932919008718 tetramer interface [polypeptide binding]; other site 932919008719 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 932919008720 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 932919008721 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 932919008722 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 932919008723 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 932919008724 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 932919008725 23S rRNA interface [nucleotide binding]; other site 932919008726 L3 interface [polypeptide binding]; other site 932919008727 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 932919008728 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 932919008729 dimerization interface 3.5A [polypeptide binding]; other site 932919008730 active site 932919008731 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 932919008732 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 932919008733 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 932919008734 Walker A/P-loop; other site 932919008735 ATP binding site [chemical binding]; other site 932919008736 Q-loop/lid; other site 932919008737 ABC transporter signature motif; other site 932919008738 Walker B; other site 932919008739 D-loop; other site 932919008740 H-loop/switch region; other site 932919008741 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 932919008742 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 932919008743 Walker A/P-loop; other site 932919008744 ATP binding site [chemical binding]; other site 932919008745 Q-loop/lid; other site 932919008746 ABC transporter signature motif; other site 932919008747 Walker B; other site 932919008748 D-loop; other site 932919008749 H-loop/switch region; other site 932919008750 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 932919008751 MgtC family; Region: MgtC; pfam02308 932919008752 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 932919008753 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 932919008754 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 932919008755 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 932919008756 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 932919008757 alphaNTD - beta interaction site [polypeptide binding]; other site 932919008758 alphaNTD homodimer interface [polypeptide binding]; other site 932919008759 alphaNTD - beta' interaction site [polypeptide binding]; other site 932919008760 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 932919008761 30S ribosomal protein S11; Validated; Region: PRK05309 932919008762 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 932919008763 30S ribosomal protein S13; Region: bact_S13; TIGR03631 932919008764 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 932919008765 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 932919008766 rRNA binding site [nucleotide binding]; other site 932919008767 predicted 30S ribosome binding site; other site 932919008768 adenylate kinase; Reviewed; Region: adk; PRK00279 932919008769 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 932919008770 AMP-binding site [chemical binding]; other site 932919008771 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 932919008772 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 932919008773 SecY translocase; Region: SecY; pfam00344 932919008774 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 932919008775 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 932919008776 23S rRNA binding site [nucleotide binding]; other site 932919008777 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 932919008778 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 932919008779 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 932919008780 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 932919008781 5S rRNA interface [nucleotide binding]; other site 932919008782 L27 interface [polypeptide binding]; other site 932919008783 23S rRNA interface [nucleotide binding]; other site 932919008784 L5 interface [polypeptide binding]; other site 932919008785 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 932919008786 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 932919008787 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 932919008788 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 932919008789 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 932919008790 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 932919008791 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 932919008792 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 932919008793 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 932919008794 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 932919008795 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 932919008796 RNA binding site [nucleotide binding]; other site 932919008797 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 932919008798 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 932919008799 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 932919008800 23S rRNA interface [nucleotide binding]; other site 932919008801 putative translocon interaction site; other site 932919008802 signal recognition particle (SRP54) interaction site; other site 932919008803 L23 interface [polypeptide binding]; other site 932919008804 trigger factor interaction site; other site 932919008805 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 932919008806 23S rRNA interface [nucleotide binding]; other site 932919008807 5S rRNA interface [nucleotide binding]; other site 932919008808 putative antibiotic binding site [chemical binding]; other site 932919008809 L25 interface [polypeptide binding]; other site 932919008810 L27 interface [polypeptide binding]; other site 932919008811 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 932919008812 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 932919008813 G-X-X-G motif; other site 932919008814 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 932919008815 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 932919008816 putative translocon binding site; other site 932919008817 protein-rRNA interface [nucleotide binding]; other site 932919008818 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 932919008819 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 932919008820 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 932919008821 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 932919008822 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 932919008823 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 932919008824 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 932919008825 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 932919008826 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 932919008827 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 932919008828 UbiA prenyltransferase family; Region: UbiA; pfam01040 932919008829 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 932919008830 ApbE family; Region: ApbE; pfam02424 932919008831 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 932919008832 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 932919008833 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 932919008834 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 932919008835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932919008836 Predicted membrane protein [Function unknown]; Region: COG2259 932919008837 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 932919008838 trimer interface [polypeptide binding]; other site 932919008839 Predicted membrane protein [Function unknown]; Region: COG4769 932919008840 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 932919008841 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 932919008842 substrate binding pocket [chemical binding]; other site 932919008843 chain length determination region; other site 932919008844 substrate-Mg2+ binding site; other site 932919008845 catalytic residues [active] 932919008846 aspartate-rich region 1; other site 932919008847 active site lid residues [active] 932919008848 aspartate-rich region 2; other site 932919008849 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 932919008850 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 932919008851 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 932919008852 active site 932919008853 metal binding site [ion binding]; metal-binding site 932919008854 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 932919008855 hypothetical protein; Provisional; Region: PRK02947 932919008856 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932919008857 putative active site [active] 932919008858 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 932919008859 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 932919008860 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 932919008861 active site 932919008862 substrate binding pocket [chemical binding]; other site 932919008863 homodimer interaction site [polypeptide binding]; other site 932919008864 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 932919008865 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 932919008866 active site 932919008867 P-loop; other site 932919008868 phosphorylation site [posttranslational modification] 932919008869 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919008870 active site 932919008871 phosphorylation site [posttranslational modification] 932919008872 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932919008873 Mga helix-turn-helix domain; Region: Mga; pfam05043 932919008874 PRD domain; Region: PRD; pfam00874 932919008875 PRD domain; Region: PRD; pfam00874 932919008876 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932919008877 active site 932919008878 P-loop; other site 932919008879 phosphorylation site [posttranslational modification] 932919008880 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919008881 active site 932919008882 phosphorylation site [posttranslational modification] 932919008883 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 932919008884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919008885 Walker A/P-loop; other site 932919008886 ATP binding site [chemical binding]; other site 932919008887 Q-loop/lid; other site 932919008888 ABC transporter signature motif; other site 932919008889 Walker B; other site 932919008890 D-loop; other site 932919008891 H-loop/switch region; other site 932919008892 elongation factor Tu; Reviewed; Region: PRK00049 932919008893 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 932919008894 G1 box; other site 932919008895 GEF interaction site [polypeptide binding]; other site 932919008896 GTP/Mg2+ binding site [chemical binding]; other site 932919008897 Switch I region; other site 932919008898 G2 box; other site 932919008899 G3 box; other site 932919008900 Switch II region; other site 932919008901 G4 box; other site 932919008902 G5 box; other site 932919008903 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 932919008904 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 932919008905 Antibiotic Binding Site [chemical binding]; other site 932919008906 elongation factor G; Reviewed; Region: PRK00007 932919008907 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 932919008908 G1 box; other site 932919008909 putative GEF interaction site [polypeptide binding]; other site 932919008910 GTP/Mg2+ binding site [chemical binding]; other site 932919008911 Switch I region; other site 932919008912 G2 box; other site 932919008913 G3 box; other site 932919008914 Switch II region; other site 932919008915 G4 box; other site 932919008916 G5 box; other site 932919008917 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 932919008918 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 932919008919 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 932919008920 30S ribosomal protein S7; Validated; Region: PRK05302 932919008921 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 932919008922 S17 interaction site [polypeptide binding]; other site 932919008923 S8 interaction site; other site 932919008924 16S rRNA interaction site [nucleotide binding]; other site 932919008925 streptomycin interaction site [chemical binding]; other site 932919008926 23S rRNA interaction site [nucleotide binding]; other site 932919008927 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 932919008928 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 932919008929 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932919008930 Zn2+ binding site [ion binding]; other site 932919008931 Mg2+ binding site [ion binding]; other site 932919008932 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 932919008933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919008934 Coenzyme A binding pocket [chemical binding]; other site 932919008935 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 932919008936 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919008937 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919008938 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 932919008939 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 932919008940 substrate binding site [chemical binding]; other site 932919008941 hexamer interface [polypeptide binding]; other site 932919008942 metal binding site [ion binding]; metal-binding site 932919008943 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 932919008944 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 932919008945 TPP-binding site [chemical binding]; other site 932919008946 dimer interface [polypeptide binding]; other site 932919008947 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 932919008948 PYR/PP interface [polypeptide binding]; other site 932919008949 dimer interface [polypeptide binding]; other site 932919008950 TPP binding site [chemical binding]; other site 932919008951 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932919008952 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 932919008953 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 932919008954 substrate binding site [chemical binding]; other site 932919008955 hexamer interface [polypeptide binding]; other site 932919008956 metal binding site [ion binding]; metal-binding site 932919008957 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 932919008958 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 932919008959 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 932919008960 putative NAD(P) binding site [chemical binding]; other site 932919008961 catalytic Zn binding site [ion binding]; other site 932919008962 structural Zn binding site [ion binding]; other site 932919008963 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 932919008964 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 932919008965 putative NAD(P) binding site [chemical binding]; other site 932919008966 catalytic Zn binding site [ion binding]; other site 932919008967 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 932919008968 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 932919008969 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 932919008970 active site 932919008971 P-loop; other site 932919008972 phosphorylation site [posttranslational modification] 932919008973 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919008974 active site 932919008975 phosphorylation site [posttranslational modification] 932919008976 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932919008977 PRD domain; Region: PRD; pfam00874 932919008978 PRD domain; Region: PRD; pfam00874 932919008979 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932919008980 active site 932919008981 P-loop; other site 932919008982 phosphorylation site [posttranslational modification] 932919008983 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 932919008984 active site 932919008985 phosphorylation site [posttranslational modification] 932919008986 Predicted membrane protein [Function unknown]; Region: COG4905 932919008987 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 932919008988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 932919008989 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 932919008990 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932919008991 active site 932919008992 Helix-turn-helix domain; Region: HTH_18; pfam12833 932919008993 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 932919008994 Ligand Binding Site [chemical binding]; other site 932919008995 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 932919008996 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 932919008997 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 932919008998 active site 932919008999 DNA binding site [nucleotide binding] 932919009000 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 932919009001 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932919009002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932919009003 active site 932919009004 phosphorylation site [posttranslational modification] 932919009005 intermolecular recognition site; other site 932919009006 dimerization interface [polypeptide binding]; other site 932919009007 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932919009008 DNA binding site [nucleotide binding] 932919009009 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 932919009010 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 932919009011 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 932919009012 Ligand Binding Site [chemical binding]; other site 932919009013 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 932919009014 GAF domain; Region: GAF_3; pfam13492 932919009015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932919009016 dimer interface [polypeptide binding]; other site 932919009017 phosphorylation site [posttranslational modification] 932919009018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932919009019 ATP binding site [chemical binding]; other site 932919009020 Mg2+ binding site [ion binding]; other site 932919009021 G-X-G motif; other site 932919009022 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 932919009023 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 932919009024 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932919009025 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 932919009026 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932919009027 active site 932919009028 P-loop; other site 932919009029 phosphorylation site [posttranslational modification] 932919009030 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932919009031 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932919009032 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932919009033 methionine cluster; other site 932919009034 active site 932919009035 phosphorylation site [posttranslational modification] 932919009036 metal binding site [ion binding]; metal-binding site 932919009037 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 932919009038 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 932919009039 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 932919009040 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 932919009041 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932919009042 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 932919009043 Soluble P-type ATPase [General function prediction only]; Region: COG4087 932919009044 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 932919009045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932919009046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932919009047 autolysin; Reviewed; Region: PRK06347 932919009048 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 932919009049 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932919009050 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932919009051 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932919009052 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932919009053 Protein of unknown function (DUF970); Region: DUF970; pfam06153 932919009054 thymidylate kinase; Validated; Region: tmk; PRK00698 932919009055 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 932919009056 TMP-binding site; other site 932919009057 ATP-binding site [chemical binding]; other site 932919009058 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 932919009059 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 932919009060 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932919009061 catalytic residue [active] 932919009062 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 932919009063 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 932919009064 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 932919009065 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 932919009066 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 932919009067 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 932919009068 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932919009069 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932919009070 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932919009071 putative active site [active] 932919009072 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 932919009073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919009074 active site 932919009075 motif I; other site 932919009076 motif II; other site 932919009077 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 932919009078 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919009079 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919009080 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919009081 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919009082 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919009083 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919009084 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919009085 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 932919009086 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932919009087 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932919009088 active site 932919009089 catalytic tetrad [active] 932919009090 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 932919009091 recombination protein RecR; Reviewed; Region: recR; PRK00076 932919009092 RecR protein; Region: RecR; pfam02132 932919009093 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 932919009094 putative active site [active] 932919009095 putative metal-binding site [ion binding]; other site 932919009096 tetramer interface [polypeptide binding]; other site 932919009097 hypothetical protein; Validated; Region: PRK00153 932919009098 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 932919009099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932919009100 Walker A motif; other site 932919009101 ATP binding site [chemical binding]; other site 932919009102 Walker B motif; other site 932919009103 arginine finger; other site 932919009104 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 932919009105 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 932919009106 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 932919009107 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932919009108 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932919009109 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 932919009110 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 932919009111 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 932919009112 N- and C-terminal domain interface [polypeptide binding]; other site 932919009113 active site 932919009114 catalytic site [active] 932919009115 metal binding site [ion binding]; metal-binding site 932919009116 carbohydrate binding site [chemical binding]; other site 932919009117 ATP binding site [chemical binding]; other site 932919009118 SH3-like domain; Region: SH3_8; pfam13457 932919009119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 932919009120 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 932919009121 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932919009122 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 932919009123 Walker A/P-loop; other site 932919009124 ATP binding site [chemical binding]; other site 932919009125 Q-loop/lid; other site 932919009126 ABC transporter signature motif; other site 932919009127 Walker B; other site 932919009128 D-loop; other site 932919009129 H-loop/switch region; other site 932919009130 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 932919009131 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932919009132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919009133 Walker A/P-loop; other site 932919009134 ATP binding site [chemical binding]; other site 932919009135 Q-loop/lid; other site 932919009136 ABC transporter signature motif; other site 932919009137 Walker B; other site 932919009138 D-loop; other site 932919009139 H-loop/switch region; other site 932919009140 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 932919009141 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 932919009142 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 932919009143 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 932919009144 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 932919009145 nucleoside/Zn binding site; other site 932919009146 dimer interface [polypeptide binding]; other site 932919009147 catalytic motif [active] 932919009148 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 932919009149 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 932919009150 active site 932919009151 acyl-activating enzyme (AAE) consensus motif; other site 932919009152 putative CoA binding site [chemical binding]; other site 932919009153 AMP binding site [chemical binding]; other site 932919009154 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 932919009155 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 932919009156 active site 932919009157 trimer interface [polypeptide binding]; other site 932919009158 allosteric site; other site 932919009159 active site lid [active] 932919009160 hexamer (dimer of trimers) interface [polypeptide binding]; other site 932919009161 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 932919009162 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 932919009163 DNA binding residues [nucleotide binding] 932919009164 drug binding residues [chemical binding]; other site 932919009165 dimer interface [polypeptide binding]; other site 932919009166 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 932919009167 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 932919009168 Coenzyme A binding pocket [chemical binding]; other site 932919009169 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 932919009170 dimer interface [polypeptide binding]; other site 932919009171 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 932919009172 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 932919009173 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932919009174 MarR family; Region: MarR; pfam01047 932919009175 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 932919009176 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 932919009177 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 932919009178 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 932919009179 DNA binding residues [nucleotide binding] 932919009180 putative dimer interface [polypeptide binding]; other site 932919009181 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 932919009182 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 932919009183 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919009184 active site 932919009185 motif I; other site 932919009186 motif II; other site 932919009187 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932919009188 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932919009189 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932919009190 putative active site [active] 932919009191 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 932919009192 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919009193 active site 932919009194 phosphorylation site [posttranslational modification] 932919009195 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932919009196 active site 932919009197 P-loop; other site 932919009198 phosphorylation site [posttranslational modification] 932919009199 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 932919009200 alpha-mannosidase; Provisional; Region: PRK09819 932919009201 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 932919009202 active site 932919009203 metal binding site [ion binding]; metal-binding site 932919009204 catalytic site [active] 932919009205 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 932919009206 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 932919009207 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 932919009208 active site 932919009209 homodimer interface [polypeptide binding]; other site 932919009210 catalytic site [active] 932919009211 glycerate kinase; Region: TIGR00045 932919009212 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932919009213 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932919009214 DNA binding site [nucleotide binding] 932919009215 domain linker motif; other site 932919009216 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 932919009217 putative dimerization interface [polypeptide binding]; other site 932919009218 putative ligand binding site [chemical binding]; other site 932919009219 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 932919009220 Domain of unknown function DUF21; Region: DUF21; pfam01595 932919009221 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 932919009222 Transporter associated domain; Region: CorC_HlyC; pfam03471 932919009223 NAD-dependent deacetylase; Provisional; Region: PRK00481 932919009224 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 932919009225 NAD+ binding site [chemical binding]; other site 932919009226 substrate binding site [chemical binding]; other site 932919009227 putative Zn binding site [ion binding]; other site 932919009228 Pathogenicity locus; Region: Cdd1; pfam11731 932919009229 drug efflux system protein MdtG; Provisional; Region: PRK09874 932919009230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919009231 putative substrate translocation pore; other site 932919009232 Src Homology 3 domain superfamily; Region: SH3; cl17036 932919009233 Variant SH3 domain; Region: SH3_2; pfam07653 932919009234 peptide ligand binding site [polypeptide binding]; other site 932919009235 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 932919009236 active site 932919009237 intersubunit interactions; other site 932919009238 catalytic residue [active] 932919009239 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 932919009240 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 932919009241 ligand binding site [chemical binding]; other site 932919009242 flexible hinge region; other site 932919009243 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 932919009244 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932919009245 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932919009246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919009247 Walker A/P-loop; other site 932919009248 ATP binding site [chemical binding]; other site 932919009249 Q-loop/lid; other site 932919009250 ABC transporter signature motif; other site 932919009251 Walker B; other site 932919009252 D-loop; other site 932919009253 H-loop/switch region; other site 932919009254 TfoX C-terminal domain; Region: TfoX_C; pfam04994 932919009255 seryl-tRNA synthetase; Provisional; Region: PRK05431 932919009256 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 932919009257 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 932919009258 dimer interface [polypeptide binding]; other site 932919009259 active site 932919009260 motif 1; other site 932919009261 motif 2; other site 932919009262 motif 3; other site 932919009263 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 932919009264 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 932919009265 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 932919009266 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 932919009267 glutamine binding [chemical binding]; other site 932919009268 catalytic triad [active] 932919009269 aminodeoxychorismate synthase; Provisional; Region: PRK07508 932919009270 chorismate binding enzyme; Region: Chorismate_bind; cl10555 932919009271 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 932919009272 substrate-cofactor binding pocket; other site 932919009273 homodimer interface [polypeptide binding]; other site 932919009274 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 932919009275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932919009276 catalytic residue [active] 932919009277 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932919009278 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932919009279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919009280 Walker A/P-loop; other site 932919009281 ATP binding site [chemical binding]; other site 932919009282 Q-loop/lid; other site 932919009283 ABC transporter signature motif; other site 932919009284 Walker B; other site 932919009285 D-loop; other site 932919009286 H-loop/switch region; other site 932919009287 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932919009288 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932919009289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932919009290 Walker A/P-loop; other site 932919009291 ATP binding site [chemical binding]; other site 932919009292 Q-loop/lid; other site 932919009293 ABC transporter signature motif; other site 932919009294 Walker B; other site 932919009295 D-loop; other site 932919009296 H-loop/switch region; other site 932919009297 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 932919009298 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 932919009299 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 932919009300 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 932919009301 Predicted acyl esterases [General function prediction only]; Region: COG2936 932919009302 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 932919009303 DNA topoisomerase III; Provisional; Region: PRK07726 932919009304 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 932919009305 active site 932919009306 putative interdomain interaction site [polypeptide binding]; other site 932919009307 putative metal-binding site [ion binding]; other site 932919009308 putative nucleotide binding site [chemical binding]; other site 932919009309 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 932919009310 domain I; other site 932919009311 DNA binding groove [nucleotide binding] 932919009312 phosphate binding site [ion binding]; other site 932919009313 domain II; other site 932919009314 domain III; other site 932919009315 nucleotide binding site [chemical binding]; other site 932919009316 catalytic site [active] 932919009317 domain IV; other site 932919009318 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 932919009319 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 932919009320 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932919009321 ATP binding site [chemical binding]; other site 932919009322 putative Mg++ binding site [ion binding]; other site 932919009323 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932919009324 nucleotide binding region [chemical binding]; other site 932919009325 ATP-binding site [chemical binding]; other site 932919009326 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 932919009327 HRDC domain; Region: HRDC; pfam00570 932919009328 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 932919009329 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 932919009330 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 932919009331 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 932919009332 active site 932919009333 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 932919009334 putative ADP-ribose binding site [chemical binding]; other site 932919009335 putative active site [active] 932919009336 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 932919009337 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932919009338 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932919009339 ABC transporter; Region: ABC_tran_2; pfam12848 932919009340 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932919009341 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932919009342 beta-galactosidase; Region: BGL; TIGR03356 932919009343 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932919009344 active site 932919009345 P-loop; other site 932919009346 phosphorylation site [posttranslational modification] 932919009347 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932919009348 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932919009349 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932919009350 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932919009351 nucleotide binding site [chemical binding]; other site 932919009352 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932919009353 methionine cluster; other site 932919009354 active site 932919009355 phosphorylation site [posttranslational modification] 932919009356 metal binding site [ion binding]; metal-binding site 932919009357 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932919009358 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932919009359 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932919009360 putative active site [active] 932919009361 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 932919009362 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 932919009363 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 932919009364 Walker A/P-loop; other site 932919009365 ATP binding site [chemical binding]; other site 932919009366 Q-loop/lid; other site 932919009367 ABC transporter signature motif; other site 932919009368 Walker B; other site 932919009369 D-loop; other site 932919009370 H-loop/switch region; other site 932919009371 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 932919009372 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 932919009373 ATP-grasp domain; Region: ATP-grasp_4; cl17255 932919009374 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 932919009375 beta-galactosidase; Region: BGL; TIGR03356 932919009376 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 932919009377 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932919009378 active site turn [active] 932919009379 phosphorylation site [posttranslational modification] 932919009380 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932919009381 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 932919009382 HPr interaction site; other site 932919009383 glycerol kinase (GK) interaction site [polypeptide binding]; other site 932919009384 active site 932919009385 phosphorylation site [posttranslational modification] 932919009386 transcriptional antiterminator BglG; Provisional; Region: PRK09772 932919009387 CAT RNA binding domain; Region: CAT_RBD; smart01061 932919009388 PRD domain; Region: PRD; pfam00874 932919009389 PRD domain; Region: PRD; pfam00874 932919009390 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932919009391 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 932919009392 Walker A/P-loop; other site 932919009393 ATP binding site [chemical binding]; other site 932919009394 Q-loop/lid; other site 932919009395 ABC transporter signature motif; other site 932919009396 Walker B; other site 932919009397 D-loop; other site 932919009398 H-loop/switch region; other site 932919009399 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 932919009400 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 932919009401 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 932919009402 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 932919009403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919009404 putative substrate translocation pore; other site 932919009405 GTP-binding protein YchF; Reviewed; Region: PRK09601 932919009406 YchF GTPase; Region: YchF; cd01900 932919009407 G1 box; other site 932919009408 GTP/Mg2+ binding site [chemical binding]; other site 932919009409 Switch I region; other site 932919009410 G2 box; other site 932919009411 Switch II region; other site 932919009412 G3 box; other site 932919009413 G4 box; other site 932919009414 G5 box; other site 932919009415 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 932919009416 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932919009417 methionine cluster; other site 932919009418 active site 932919009419 phosphorylation site [posttranslational modification] 932919009420 metal binding site [ion binding]; metal-binding site 932919009421 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 932919009422 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 932919009423 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 932919009424 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932919009425 active site 932919009426 P-loop; other site 932919009427 phosphorylation site [posttranslational modification] 932919009428 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932919009429 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 932919009430 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932919009431 HTH domain; Region: HTH_11; pfam08279 932919009432 Mga helix-turn-helix domain; Region: Mga; pfam05043 932919009433 PRD domain; Region: PRD; pfam00874 932919009434 PRD domain; Region: PRD; pfam00874 932919009435 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932919009436 active site 932919009437 P-loop; other site 932919009438 phosphorylation site [posttranslational modification] 932919009439 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919009440 active site 932919009441 phosphorylation site [posttranslational modification] 932919009442 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 932919009443 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 932919009444 tetramer interface [polypeptide binding]; other site 932919009445 heme binding pocket [chemical binding]; other site 932919009446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 932919009447 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 932919009448 ParB-like nuclease domain; Region: ParB; smart00470 932919009449 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 932919009450 salt bridge; other site 932919009451 non-specific DNA binding site [nucleotide binding]; other site 932919009452 sequence-specific DNA binding site [nucleotide binding]; other site 932919009453 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 932919009454 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 932919009455 P-loop; other site 932919009456 Magnesium ion binding site [ion binding]; other site 932919009457 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 932919009458 Magnesium ion binding site [ion binding]; other site 932919009459 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 932919009460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932919009461 non-specific DNA binding site [nucleotide binding]; other site 932919009462 salt bridge; other site 932919009463 sequence-specific DNA binding site [nucleotide binding]; other site 932919009464 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 932919009465 ParB-like nuclease domain; Region: ParBc; pfam02195 932919009466 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932919009467 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932919009468 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932919009469 putative active site [active] 932919009470 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932919009471 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932919009472 nucleotide binding site [chemical binding]; other site 932919009473 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932919009474 active site 932919009475 phosphorylation site [posttranslational modification] 932919009476 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 932919009477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919009478 motif II; other site 932919009479 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 932919009480 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 932919009481 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 932919009482 active site 932919009483 P-loop; other site 932919009484 phosphorylation site [posttranslational modification] 932919009485 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932919009486 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932919009487 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932919009488 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 932919009489 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 932919009490 putative active site cavity [active] 932919009491 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 932919009492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932919009493 S-adenosylmethionine binding site [chemical binding]; other site 932919009494 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 932919009495 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 932919009496 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 932919009497 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 932919009498 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 932919009499 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 932919009500 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 932919009501 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 932919009502 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 932919009503 trmE is a tRNA modification GTPase; Region: trmE; cd04164 932919009504 G1 box; other site 932919009505 GTP/Mg2+ binding site [chemical binding]; other site 932919009506 Switch I region; other site 932919009507 G2 box; other site 932919009508 Switch II region; other site 932919009509 G3 box; other site 932919009510 G4 box; other site 932919009511 G5 box; other site 932919009512 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 932919009513 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 932919009514 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 932919009515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932919009516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932919009517 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 932919009518 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 932919009519 NADP binding site [chemical binding]; other site 932919009520 homodimer interface [polypeptide binding]; other site 932919009521 active site 932919009522 substrate binding site [chemical binding]; other site 932919009523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919009524 D-galactonate transporter; Region: 2A0114; TIGR00893 932919009525 putative substrate translocation pore; other site 932919009526 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 932919009527 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 932919009528 metal binding site [ion binding]; metal-binding site 932919009529 dimer interface [polypeptide binding]; other site 932919009530 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 932919009531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 932919009532 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 932919009533 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 932919009534 metal binding site [ion binding]; metal-binding site 932919009535 dimer interface [polypeptide binding]; other site 932919009536 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932919009537 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932919009538 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 932919009539 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 932919009540 Leucine-rich repeats; other site 932919009541 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919009542 Substrate binding site [chemical binding]; other site 932919009543 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 932919009544 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919009545 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919009546 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919009547 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919009548 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 932919009549 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 932919009550 Uncharacterized conserved protein [Function unknown]; Region: COG4198 932919009551 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 932919009552 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 932919009553 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 932919009554 putative ligand binding site [chemical binding]; other site 932919009555 putative NAD binding site [chemical binding]; other site 932919009556 putative catalytic site [active] 932919009557 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 932919009558 L-serine binding site [chemical binding]; other site 932919009559 ACT domain interface; other site 932919009560 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 932919009561 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932919009562 catalytic residue [active] 932919009563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919009564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932919009565 putative substrate translocation pore; other site 932919009566 Transcriptional regulators [Transcription]; Region: MarR; COG1846 932919009567 MarR family; Region: MarR_2; pfam12802 932919009568 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 932919009569 dimer interface [polypeptide binding]; other site 932919009570 FMN binding site [chemical binding]; other site 932919009571 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 932919009572 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 932919009573 catalytic residues [active] 932919009574 beta-phosphoglucomutase; Region: bPGM; TIGR01990 932919009575 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 932919009576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932919009577 motif II; other site 932919009578 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 932919009579 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 932919009580 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 932919009581 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 932919009582 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 932919009583 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932919009584 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932919009585 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932919009586 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 932919009587 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 932919009588 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 932919009589 putative NAD(P) binding site [chemical binding]; other site 932919009590 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932919009591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919009592 dimer interface [polypeptide binding]; other site 932919009593 conserved gate region; other site 932919009594 putative PBP binding loops; other site 932919009595 ABC-ATPase subunit interface; other site 932919009596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932919009597 dimer interface [polypeptide binding]; other site 932919009598 conserved gate region; other site 932919009599 putative PBP binding loops; other site 932919009600 ABC-ATPase subunit interface; other site 932919009601 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 932919009602 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932919009603 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 932919009604 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 932919009605 active site 932919009606 homodimer interface [polypeptide binding]; other site 932919009607 catalytic site [active] 932919009608 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932919009609 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932919009610 DNA binding site [nucleotide binding] 932919009611 domain linker motif; other site 932919009612 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 932919009613 putative dimerization interface [polypeptide binding]; other site 932919009614 putative ligand binding site [chemical binding]; other site 932919009615 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 932919009616 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 932919009617 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932919009618 Coenzyme A binding pocket [chemical binding]; other site 932919009619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919009620 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932919009621 putative substrate translocation pore; other site 932919009622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919009623 Domain of unknown function (DUF718); Region: DUF718; cl01281 932919009624 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 932919009625 intersubunit interface [polypeptide binding]; other site 932919009626 active site 932919009627 Zn2+ binding site [ion binding]; other site 932919009628 L-rhamnose isomerase; Provisional; Region: PRK01076 932919009629 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 932919009630 N- and C-terminal domain interface [polypeptide binding]; other site 932919009631 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 932919009632 active site 932919009633 putative catalytic site [active] 932919009634 metal binding site [ion binding]; metal-binding site 932919009635 ATP binding site [chemical binding]; other site 932919009636 carbohydrate binding site [chemical binding]; other site 932919009637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932919009638 putative substrate translocation pore; other site 932919009639 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932919009640 Cupin domain; Region: Cupin_2; pfam07883 932919009641 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932919009642 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 932919009643 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 932919009644 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 932919009645 G-X-X-G motif; other site 932919009646 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 932919009647 RxxxH motif; other site 932919009648 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 932919009649 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 932919009650 ribonuclease P; Reviewed; Region: rnpA; PRK00499 932919009651 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399