-- dump date   	20140619_133851
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
563174000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
563174000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
563174000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174000004	Walker A motif; other site
563174000005	ATP binding site [chemical binding]; other site
563174000006	Walker B motif; other site
563174000007	arginine finger; other site
563174000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
563174000009	DnaA box-binding interface [nucleotide binding]; other site
563174000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
563174000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
563174000012	putative DNA binding surface [nucleotide binding]; other site
563174000013	dimer interface [polypeptide binding]; other site
563174000014	beta-clamp/clamp loader binding surface; other site
563174000015	beta-clamp/translesion DNA polymerase binding surface; other site
563174000016	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
563174000017	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
563174000018	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
563174000019	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
563174000020	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
563174000021	Walker A/P-loop; other site
563174000022	ATP binding site [chemical binding]; other site
563174000023	Q-loop/lid; other site
563174000024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174000025	ABC transporter signature motif; other site
563174000026	Walker B; other site
563174000027	D-loop; other site
563174000028	H-loop/switch region; other site
563174000029	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
563174000030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174000031	Mg2+ binding site [ion binding]; other site
563174000032	G-X-G motif; other site
563174000033	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
563174000034	anchoring element; other site
563174000035	dimer interface [polypeptide binding]; other site
563174000036	ATP binding site [chemical binding]; other site
563174000037	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
563174000038	active site
563174000039	putative metal-binding site [ion binding]; other site
563174000040	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
563174000041	DNA gyrase subunit A; Validated; Region: PRK05560
563174000042	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
563174000043	CAP-like domain; other site
563174000044	active site
563174000045	primary dimer interface [polypeptide binding]; other site
563174000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
563174000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
563174000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
563174000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
563174000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
563174000051	cardiolipin synthetase; Reviewed; Region: PRK12452
563174000052	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
563174000053	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
563174000054	putative active site [active]
563174000055	catalytic site [active]
563174000056	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
563174000057	putative active site [active]
563174000058	catalytic site [active]
563174000059	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
563174000060	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174000061	Coenzyme A binding pocket [chemical binding]; other site
563174000062	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
563174000063	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
563174000064	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
563174000065	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
563174000066	diphosphomevalonate decarboxylase; Region: PLN02407
563174000067	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
563174000068	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
563174000069	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
563174000070	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
563174000071	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
563174000072	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
563174000073	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
563174000074	D-pathway; other site
563174000075	Putative ubiquinol binding site [chemical binding]; other site
563174000076	Low-spin heme (heme b) binding site [chemical binding]; other site
563174000077	Putative water exit pathway; other site
563174000078	Binuclear center (heme o3/CuB) [ion binding]; other site
563174000079	K-pathway; other site
563174000080	Putative proton exit pathway; other site
563174000081	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
563174000082	Subunit I/III interface [polypeptide binding]; other site
563174000083	Subunit III/IV interface [polypeptide binding]; other site
563174000084	cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901
563174000085	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
563174000086	beta-galactosidase; Region: BGL; TIGR03356
563174000087	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
563174000088	Bacterial SH3 domain; Region: SH3_3; pfam08239
563174000089	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
563174000090	putative active site [active]
563174000091	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
563174000092	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174000093	DNA-binding site [nucleotide binding]; DNA binding site
563174000094	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
563174000095	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
563174000096	active site
563174000097	active pocket/dimerization site; other site
563174000098	phosphorylation site [posttranslational modification]
563174000099	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
563174000100	active site
563174000101	phosphorylation site [posttranslational modification]
563174000102	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
563174000103	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
563174000104	hypothetical protein; Provisional; Region: PRK02947
563174000105	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
563174000106	putative active site [active]
563174000107	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
563174000108	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
563174000109	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
563174000110	active site turn [active]
563174000111	phosphorylation site [posttranslational modification]
563174000112	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
563174000113	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
563174000114	HPr interaction site; other site
563174000115	glycerol kinase (GK) interaction site [polypeptide binding]; other site
563174000116	active site
563174000117	phosphorylation site [posttranslational modification]
563174000118	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
563174000119	putative dimer interface [polypeptide binding]; other site
563174000120	catalytic triad [active]
563174000121	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
563174000122	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174000123	active site
563174000124	motif I; other site
563174000125	motif II; other site
563174000126	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174000127	Transcriptional regulators [Transcription]; Region: PurR; COG1609
563174000128	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
563174000129	DNA binding site [nucleotide binding]
563174000130	domain linker motif; other site
563174000131	Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
563174000132	dimerization interface [polypeptide binding]; other site
563174000133	putative ligand binding site [chemical binding]; other site
563174000134	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
563174000135	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
563174000136	nucleotide binding site [chemical binding]; other site
563174000137	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
563174000138	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
563174000139	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
563174000140	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
563174000141	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
563174000142	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
563174000143	dimer interface [polypeptide binding]; other site
563174000144	active site
563174000145	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
563174000146	dimer interface [polypeptide binding]; other site
563174000147	active site
563174000148	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
563174000149	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
563174000150	arginine deiminase; Provisional; Region: PRK01388
563174000151	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
563174000152	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
563174000153	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
563174000154	dimer interface [polypeptide binding]; other site
563174000155	ssDNA binding site [nucleotide binding]; other site
563174000156	tetramer (dimer of dimers) interface [polypeptide binding]; other site
563174000157	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
563174000158	Predicted membrane protein [Function unknown]; Region: COG3212
563174000159	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
563174000160	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
563174000161	putative accessory gene regulator protein; Provisional; Region: PRK01100
563174000162	Staphylococcal AgrD protein; Region: AgrD; cl05477
563174000163	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
563174000164	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174000165	ATP binding site [chemical binding]; other site
563174000166	Mg2+ binding site [ion binding]; other site
563174000167	G-X-G motif; other site
563174000168	Response regulator receiver domain; Region: Response_reg; pfam00072
563174000169	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174000170	active site
563174000171	phosphorylation site [posttranslational modification]
563174000172	intermolecular recognition site; other site
563174000173	dimerization interface [polypeptide binding]; other site
563174000174	LytTr DNA-binding domain; Region: LytTR; pfam04397
563174000175	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
563174000176	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
563174000177	DHH family; Region: DHH; pfam01368
563174000178	DHHA1 domain; Region: DHHA1; pfam02272
563174000179	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
563174000180	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
563174000181	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
563174000182	replicative DNA helicase; Provisional; Region: PRK05748
563174000183	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
563174000184	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
563174000185	Walker A motif; other site
563174000186	ATP binding site [chemical binding]; other site
563174000187	Walker B motif; other site
563174000188	DNA binding loops [nucleotide binding]
563174000189	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
563174000190	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
563174000191	GDP-binding site [chemical binding]; other site
563174000192	ACT binding site; other site
563174000193	IMP binding site; other site
563174000194	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
563174000195	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
563174000196	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
563174000197	Predicted membrane protein [Function unknown]; Region: COG1511
563174000198	WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266
563174000199	Uncharacterized small protein [Function unknown]; Region: COG5417
563174000200	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868
563174000201	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
563174000202	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
563174000203	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
563174000204	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
563174000205	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
563174000206	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
563174000207	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
563174000208	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
563174000209	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
563174000210	tetramer interface [polypeptide binding]; other site
563174000211	active site
563174000212	Mg2+/Mn2+ binding site [ion binding]; other site
563174000213	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
563174000214	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
563174000215	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
563174000216	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
563174000217	DNA binding site [nucleotide binding]
563174000218	active site
563174000219	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
563174000220	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
563174000221	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
563174000222	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
563174000223	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
563174000224	putative ligand binding site [chemical binding]; other site
563174000225	putative NAD binding site [chemical binding]; other site
563174000226	catalytic site [active]
563174000227	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
563174000228	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
563174000229	Int/Topo IB signature motif; other site
563174000230	extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
563174000231	Domain of unknown function (DUF955); Region: DUF955; cl01076
563174000232	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174000233	non-specific DNA binding site [nucleotide binding]; other site
563174000234	salt bridge; other site
563174000235	sequence-specific DNA binding site [nucleotide binding]; other site
563174000236	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174000237	non-specific DNA binding site [nucleotide binding]; other site
563174000238	salt bridge; other site
563174000239	sequence-specific DNA binding site [nucleotide binding]; other site
563174000240	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
563174000241	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
563174000242	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
563174000243	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
563174000244	active site
563174000245	substrate binding site [chemical binding]; other site
563174000246	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
563174000247	active site
563174000248	DNA binding site [nucleotide binding]
563174000249	catalytic site [active]
563174000250	YopX protein; Region: YopX; pfam09643
563174000251	Virulence-associated protein E; Region: VirE; pfam05272
563174000252	VRR-NUC domain; Region: VRR_NUC; pfam08774
563174000253	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
563174000254	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
563174000255	ATP binding site [chemical binding]; other site
563174000256	putative Mg++ binding site [ion binding]; other site
563174000257	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
563174000258	nucleotide binding region [chemical binding]; other site
563174000259	ATP-binding site [chemical binding]; other site
563174000260	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
563174000261	putative metal binding site [ion binding]; other site
563174000262	HTH domain; Region: HTH_11; cl17392
563174000263	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
563174000264	Phage portal protein; Region: Phage_portal; pfam04860
563174000265	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
563174000266	oligomer interface [polypeptide binding]; other site
563174000267	active site residues [active]
563174000268	Phage capsid family; Region: Phage_capsid; pfam05065
563174000269	HeH/LEM domain; Region: HeH; pfam12949
563174000270	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
563174000271	Bacteriophage holin; Region: Phage_holin_1; pfam04531
563174000272	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
563174000273	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
563174000274	amidase catalytic site [active]
563174000275	Zn binding residues [ion binding]; other site
563174000276	substrate binding site [chemical binding]; other site
563174000277	Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423
563174000278	TM2 domain; Region: TM2; pfam05154
563174000279	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
563174000280	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
563174000281	DNA binding residues [nucleotide binding]
563174000282	putative dimer interface [polypeptide binding]; other site
563174000283	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
563174000284	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
563174000285	active site
563174000286	catalytic tetrad [active]
563174000287	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174000288	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
563174000289	ATP synthase subunit C; Region: ATP-synt_C; cl00466
563174000290	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
563174000291	F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343
563174000292	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
563174000293	Walker A motif; other site
563174000294	ATP binding site [chemical binding]; other site
563174000295	Walker B motif; other site
563174000296	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
563174000297	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
563174000298	core domain interface [polypeptide binding]; other site
563174000299	delta subunit interface [polypeptide binding]; other site
563174000300	epsilon subunit interface [polypeptide binding]; other site
563174000301	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
563174000302	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
563174000303	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
563174000304	alpha subunit interaction interface [polypeptide binding]; other site
563174000305	Walker A motif; other site
563174000306	ATP binding site [chemical binding]; other site
563174000307	Walker B motif; other site
563174000308	inhibitor binding site; inhibition site
563174000309	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
563174000310	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
563174000311	gamma subunit interface [polypeptide binding]; other site
563174000312	epsilon subunit interface [polypeptide binding]; other site
563174000313	LBP interface [polypeptide binding]; other site
563174000314	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
563174000315	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
563174000316	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
563174000317	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
563174000318	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
563174000319	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
563174000320	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
563174000321	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174000322	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
563174000323	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
563174000324	active pocket/dimerization site; other site
563174000325	active site
563174000326	phosphorylation site [posttranslational modification]
563174000327	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
563174000328	active site
563174000329	phosphorylation site [posttranslational modification]
563174000330	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
563174000331	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
563174000332	Domain of unknown function (DUF956); Region: DUF956; pfam06115
563174000333	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
563174000334	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
563174000335	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
563174000336	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
563174000337	dimerization interface [polypeptide binding]; other site
563174000338	putative DNA binding site [nucleotide binding]; other site
563174000339	Uncharacterized conserved protein [Function unknown]; Region: COG1359
563174000340	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
563174000341	dimer interface [polypeptide binding]; other site
563174000342	FMN binding site [chemical binding]; other site
563174000343	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
563174000344	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
563174000345	active site
563174000346	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
563174000347	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
563174000348	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
563174000349	aromatic chitin/cellulose binding site residues [chemical binding]; other site
563174000350	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
563174000351	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
563174000352	nucleotide binding site [chemical binding]; other site
563174000353	butyrate kinase; Region: butyr_kinase; TIGR02707
563174000354	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
563174000355	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
563174000356	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
563174000357	Walker A/P-loop; other site
563174000358	ATP binding site [chemical binding]; other site
563174000359	Q-loop/lid; other site
563174000360	ABC transporter signature motif; other site
563174000361	Walker B; other site
563174000362	D-loop; other site
563174000363	H-loop/switch region; other site
563174000364	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
563174000365	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
563174000366	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
563174000367	Walker A/P-loop; other site
563174000368	ATP binding site [chemical binding]; other site
563174000369	Q-loop/lid; other site
563174000370	ABC transporter signature motif; other site
563174000371	Walker B; other site
563174000372	D-loop; other site
563174000373	H-loop/switch region; other site
563174000374	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
563174000375	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
563174000376	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
563174000377	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
563174000378	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
563174000379	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
563174000380	substrate binding pocket [chemical binding]; other site
563174000381	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
563174000382	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
563174000383	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174000384	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
563174000385	ligand binding site [chemical binding]; other site
563174000386	flexible hinge region; other site
563174000387	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
563174000388	Domain of unknown function (DUF955); Region: DUF955; pfam06114
563174000389	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174000390	non-specific DNA binding site [nucleotide binding]; other site
563174000391	salt bridge; other site
563174000392	sequence-specific DNA binding site [nucleotide binding]; other site
563174000393	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
563174000394	Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824
563174000395	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
563174000396	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
563174000397	active site
563174000398	metal binding site [ion binding]; metal-binding site
563174000399	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
563174000400	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
563174000401	putative active site [active]
563174000402	putative metal binding site [ion binding]; other site
563174000403	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
563174000404	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
563174000405	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107
563174000406	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
563174000407	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602
563174000408	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
563174000409	active site
563174000410	Uncharacterized conserved protein [Function unknown]; Region: COG3592
563174000411	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174000412	Coenzyme A binding pocket [chemical binding]; other site
563174000413	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
563174000414	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
563174000415	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
563174000416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174000417	dimer interface [polypeptide binding]; other site
563174000418	conserved gate region; other site
563174000419	putative PBP binding loops; other site
563174000420	ABC-ATPase subunit interface; other site
563174000421	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
563174000422	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
563174000423	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174000424	dimer interface [polypeptide binding]; other site
563174000425	conserved gate region; other site
563174000426	putative PBP binding loops; other site
563174000427	ABC-ATPase subunit interface; other site
563174000428	Protein of unknown function (DUF3130; Region: DUF3130; cl12867
563174000429	LXG domain of WXG superfamily; Region: LXG; pfam04740
563174000430	ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346
563174000431	phosphoenolpyruvate synthase; Validated; Region: PRK06464
563174000432	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
563174000433	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
563174000434	peptide binding site [polypeptide binding]; other site
563174000435	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
563174000436	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
563174000437	metal binding site [ion binding]; metal-binding site
563174000438	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
563174000439	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
563174000440	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
563174000441	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
563174000442	ABC-ATPase subunit  interface; other site
563174000443	dimer interface [polypeptide binding]; other site
563174000444	putative PBP binding regions; other site
563174000445	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174000446	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
563174000447	ligand binding site [chemical binding]; other site
563174000448	flexible hinge region; other site
563174000449	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
563174000450	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
563174000451	DEAD_2; Region: DEAD_2; pfam06733
563174000452	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
563174000453	sugar phosphate phosphatase; Provisional; Region: PRK10513
563174000454	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174000455	active site
563174000456	motif I; other site
563174000457	motif II; other site
563174000458	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174000459	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
563174000460	Collagen binding domain; Region: Collagen_bind; pfam05737
563174000461	Cna protein B-type domain; Region: Cna_B; pfam05738
563174000462	Cna protein B-type domain; Region: Cna_B; pfam05738
563174000463	Cna protein B-type domain; Region: Cna_B; pfam05738
563174000464	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
563174000465	Collagen binding domain; Region: Collagen_bind; pfam05737
563174000466	Cna protein B-type domain; Region: Cna_B; pfam05738
563174000467	Cna protein B-type domain; Region: Cna_B; pfam05738
563174000468	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
563174000469	DNA polymerase III subunit delta'; Validated; Region: PRK08058
563174000470	DNA polymerase III subunit delta'; Validated; Region: PRK08485
563174000471	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
563174000472	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467
563174000473	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
563174000474	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174000475	S-adenosylmethionine binding site [chemical binding]; other site
563174000476	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
563174000477	GIY-YIG motif/motif A; other site
563174000478	putative active site [active]
563174000479	putative metal binding site [ion binding]; other site
563174000480	Predicted methyltransferases [General function prediction only]; Region: COG0313
563174000481	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
563174000482	putative SAM binding site [chemical binding]; other site
563174000483	putative homodimer interface [polypeptide binding]; other site
563174000484	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
563174000485	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
563174000486	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
563174000487	Uncharacterized conserved protein [Function unknown]; Region: COG5361
563174000488	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
563174000489	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
563174000490	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174000491	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
563174000492	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
563174000493	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
563174000494	active site
563174000495	HIGH motif; other site
563174000496	KMSKS motif; other site
563174000497	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
563174000498	tRNA binding surface [nucleotide binding]; other site
563174000499	anticodon binding site; other site
563174000500	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
563174000501	dimer interface [polypeptide binding]; other site
563174000502	putative tRNA-binding site [nucleotide binding]; other site
563174000503	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
563174000504	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
563174000505	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
563174000506	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
563174000507	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
563174000508	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174000509	dimer interface [polypeptide binding]; other site
563174000510	conserved gate region; other site
563174000511	putative PBP binding loops; other site
563174000512	ABC-ATPase subunit interface; other site
563174000513	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
563174000514	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174000515	dimer interface [polypeptide binding]; other site
563174000516	conserved gate region; other site
563174000517	putative PBP binding loops; other site
563174000518	ABC-ATPase subunit interface; other site
563174000519	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
563174000520	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
563174000521	alpha-glucosidase; Provisional; Region: PRK10426
563174000522	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
563174000523	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
563174000524	active site
563174000525	catalytic site [active]
563174000526	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
563174000527	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
563174000528	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
563174000529	trimer interface [polypeptide binding]; other site
563174000530	active site
563174000531	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
563174000532	catalytic site [active]
563174000533	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
563174000534	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
563174000535	Ca binding site [ion binding]; other site
563174000536	active site
563174000537	catalytic site [active]
563174000538	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
563174000539	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
563174000540	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
563174000541	active site
563174000542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
563174000543	Domain of unknown function (DUF348); Region: DUF348; pfam03990
563174000544	Domain of unknown function (DUF348); Region: DUF348; pfam03990
563174000545	G5 domain; Region: G5; pfam07501
563174000546	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
563174000547	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
563174000548	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
563174000549	putative active site [active]
563174000550	putative metal binding site [ion binding]; other site
563174000551	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
563174000552	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
563174000553	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174000554	S-adenosylmethionine binding site [chemical binding]; other site
563174000555	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
563174000556	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
563174000557	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
563174000558	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
563174000559	putative active site [active]
563174000560	YdjC motif; other site
563174000561	Mg binding site [ion binding]; other site
563174000562	putative homodimer interface [polypeptide binding]; other site
563174000563	pur operon repressor; Provisional; Region: PRK09213
563174000564	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
563174000565	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
563174000566	active site
563174000567	HlyD family secretion protein; Region: HlyD_3; pfam13437
563174000568	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
563174000569	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
563174000570	Walker A/P-loop; other site
563174000571	ATP binding site [chemical binding]; other site
563174000572	Q-loop/lid; other site
563174000573	ABC transporter signature motif; other site
563174000574	Walker B; other site
563174000575	D-loop; other site
563174000576	H-loop/switch region; other site
563174000577	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
563174000578	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
563174000579	FtsX-like permease family; Region: FtsX; pfam02687
563174000580	regulatory protein SpoVG; Reviewed; Region: PRK13259
563174000581	regulatory protein SpoVG; Reviewed; Region: PRK13259
563174000582	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
563174000583	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
563174000584	Substrate binding site; other site
563174000585	Mg++ binding site; other site
563174000586	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
563174000587	active site
563174000588	substrate binding site [chemical binding]; other site
563174000589	CoA binding site [chemical binding]; other site
563174000590	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
563174000591	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
563174000592	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
563174000593	active site
563174000594	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174000595	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
563174000596	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
563174000597	Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137
563174000598	active site
563174000599	catalytic site [active]
563174000600	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
563174000601	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
563174000602	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
563174000603	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
563174000604	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
563174000605	active site
563174000606	Zn binding site [ion binding]; other site
563174000607	ActA Protein; Region: ActA; pfam05058
563174000608	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
563174000609	Zn binding site [ion binding]; other site
563174000610	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
563174000611	hypothetical protein; Provisional; Region: PRK01119
563174000612	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
563174000613	A new structural DNA glycosylase; Region: AlkD_like; cl11434
563174000614	active site
563174000615	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
563174000616	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
563174000617	tetramer (dimer of dimers) interface [polypeptide binding]; other site
563174000618	NAD binding site [chemical binding]; other site
563174000619	dimer interface [polypeptide binding]; other site
563174000620	substrate binding site [chemical binding]; other site
563174000621	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
563174000622	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
563174000623	5S rRNA interface [nucleotide binding]; other site
563174000624	CTC domain interface [polypeptide binding]; other site
563174000625	L16 interface [polypeptide binding]; other site
563174000626	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
563174000627	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174000628	Coenzyme A binding pocket [chemical binding]; other site
563174000629	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
563174000630	putative active site [active]
563174000631	catalytic residue [active]
563174000632	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
563174000633	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
563174000634	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
563174000635	ATP binding site [chemical binding]; other site
563174000636	putative Mg++ binding site [ion binding]; other site
563174000637	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
563174000638	nucleotide binding region [chemical binding]; other site
563174000639	ATP-binding site [chemical binding]; other site
563174000640	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
563174000641	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
563174000642	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
563174000643	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
563174000644	RNA binding surface [nucleotide binding]; other site
563174000645	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
563174000646	Septum formation initiator; Region: DivIC; pfam04977
563174000647	hypothetical protein; Provisional; Region: PRK08582
563174000648	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
563174000649	RNA binding site [nucleotide binding]; other site
563174000650	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
563174000651	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
563174000652	Ligand Binding Site [chemical binding]; other site
563174000653	TilS substrate C-terminal domain; Region: TilS_C; smart00977
563174000654	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
563174000655	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
563174000656	active site
563174000657	FtsH Extracellular; Region: FtsH_ext; pfam06480
563174000658	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
563174000659	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174000660	Walker A motif; other site
563174000661	ATP binding site [chemical binding]; other site
563174000662	Walker B motif; other site
563174000663	arginine finger; other site
563174000664	Peptidase family M41; Region: Peptidase_M41; pfam01434
563174000665	pantothenate kinase; Reviewed; Region: PRK13318
563174000666	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
563174000667	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
563174000668	dimerization interface [polypeptide binding]; other site
563174000669	domain crossover interface; other site
563174000670	redox-dependent activation switch; other site
563174000671	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
563174000672	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
563174000673	dimer interface [polypeptide binding]; other site
563174000674	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174000675	catalytic residue [active]
563174000676	dihydropteroate synthase; Region: DHPS; TIGR01496
563174000677	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
563174000678	substrate binding pocket [chemical binding]; other site
563174000679	dimer interface [polypeptide binding]; other site
563174000680	inhibitor binding site; inhibition site
563174000681	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
563174000682	homooctamer interface [polypeptide binding]; other site
563174000683	active site
563174000684	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
563174000685	catalytic center binding site [active]
563174000686	ATP binding site [chemical binding]; other site
563174000687	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
563174000688	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
563174000689	FMN binding site [chemical binding]; other site
563174000690	active site
563174000691	catalytic residues [active]
563174000692	substrate binding site [chemical binding]; other site
563174000693	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
563174000694	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
563174000695	dimer interface [polypeptide binding]; other site
563174000696	putative anticodon binding site; other site
563174000697	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
563174000698	motif 1; other site
563174000699	active site
563174000700	motif 2; other site
563174000701	motif 3; other site
563174000702	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
563174000703	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
563174000704	UvrB/uvrC motif; Region: UVR; pfam02151
563174000705	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
563174000706	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
563174000707	ADP binding site [chemical binding]; other site
563174000708	phosphagen binding site; other site
563174000709	substrate specificity loop; other site
563174000710	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
563174000711	Clp amino terminal domain; Region: Clp_N; pfam02861
563174000712	Clp amino terminal domain; Region: Clp_N; pfam02861
563174000713	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174000714	Walker A motif; other site
563174000715	ATP binding site [chemical binding]; other site
563174000716	Walker B motif; other site
563174000717	arginine finger; other site
563174000718	UvrB/uvrC motif; Region: UVR; pfam02151
563174000719	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174000720	Walker A motif; other site
563174000721	ATP binding site [chemical binding]; other site
563174000722	Walker B motif; other site
563174000723	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
563174000724	DNA repair protein RadA; Provisional; Region: PRK11823
563174000725	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
563174000726	Walker A motif/ATP binding site; other site
563174000727	ATP binding site [chemical binding]; other site
563174000728	Walker B motif; other site
563174000729	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
563174000730	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
563174000731	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
563174000732	putative active site [active]
563174000733	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
563174000734	substrate binding site; other site
563174000735	dimer interface; other site
563174000736	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
563174000737	homotrimer interaction site [polypeptide binding]; other site
563174000738	zinc binding site [ion binding]; other site
563174000739	CDP-binding sites; other site
563174000740	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
563174000741	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
563174000742	HIGH motif; other site
563174000743	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
563174000744	active site
563174000745	KMSKS motif; other site
563174000746	serine O-acetyltransferase; Region: cysE; TIGR01172
563174000747	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
563174000748	trimer interface [polypeptide binding]; other site
563174000749	active site
563174000750	substrate binding site [chemical binding]; other site
563174000751	CoA binding site [chemical binding]; other site
563174000752	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
563174000753	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
563174000754	active site
563174000755	HIGH motif; other site
563174000756	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
563174000757	KMSKS motif; other site
563174000758	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
563174000759	tRNA binding surface [nucleotide binding]; other site
563174000760	anticodon binding site; other site
563174000761	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
563174000762	active site
563174000763	metal binding site [ion binding]; metal-binding site
563174000764	dimerization interface [polypeptide binding]; other site
563174000765	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
563174000766	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
563174000767	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
563174000768	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
563174000769	RNA polymerase factor sigma-70; Validated; Region: PRK08295
563174000770	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
563174000771	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
563174000772	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
563174000773	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
563174000774	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
563174000775	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
563174000776	putative homodimer interface [polypeptide binding]; other site
563174000777	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
563174000778	heterodimer interface [polypeptide binding]; other site
563174000779	homodimer interface [polypeptide binding]; other site
563174000780	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
563174000781	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
563174000782	23S rRNA interface [nucleotide binding]; other site
563174000783	L7/L12 interface [polypeptide binding]; other site
563174000784	putative thiostrepton binding site; other site
563174000785	L25 interface [polypeptide binding]; other site
563174000786	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
563174000787	mRNA/rRNA interface [nucleotide binding]; other site
563174000788	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
563174000789	23S rRNA interface [nucleotide binding]; other site
563174000790	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
563174000791	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
563174000792	core dimer interface [polypeptide binding]; other site
563174000793	peripheral dimer interface [polypeptide binding]; other site
563174000794	L10 interface [polypeptide binding]; other site
563174000795	L11 interface [polypeptide binding]; other site
563174000796	putative EF-Tu interaction site [polypeptide binding]; other site
563174000797	putative EF-G interaction site [polypeptide binding]; other site
563174000798	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
563174000799	Penicillinase repressor; Region: Pencillinase_R; pfam03965
563174000800	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
563174000801	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
563174000802	Protein of unknown function (DUF1307); Region: DUF1307; pfam06998
563174000803	Methyltransferase domain; Region: Methyltransf_31; pfam13847
563174000804	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174000805	S-adenosylmethionine binding site [chemical binding]; other site
563174000806	Protein of unknown function (DUF3916); Region: DUF3916; pfam13079
563174000807	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
563174000808	Protein of unknown function (DUF2947); Region: DUF2947; pfam11163
563174000809	Transcriptional regulators [Transcription]; Region: PurR; COG1609
563174000810	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
563174000811	DNA binding site [nucleotide binding]
563174000812	domain linker motif; other site
563174000813	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
563174000814	putative dimerization interface [polypeptide binding]; other site
563174000815	putative ligand binding site [chemical binding]; other site
563174000816	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
563174000817	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
563174000818	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
563174000819	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174000820	dimer interface [polypeptide binding]; other site
563174000821	conserved gate region; other site
563174000822	putative PBP binding loops; other site
563174000823	ABC-ATPase subunit interface; other site
563174000824	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
563174000825	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174000826	dimer interface [polypeptide binding]; other site
563174000827	conserved gate region; other site
563174000828	putative PBP binding loops; other site
563174000829	ABC-ATPase subunit interface; other site
563174000830	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
563174000831	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
563174000832	Ca binding site [ion binding]; other site
563174000833	active site
563174000834	catalytic site [active]
563174000835	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
563174000836	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
563174000837	active site
563174000838	homodimer interface [polypeptide binding]; other site
563174000839	catalytic site [active]
563174000840	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
563174000841	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
563174000842	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
563174000843	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
563174000844	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
563174000845	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
563174000846	RPB10 interaction site [polypeptide binding]; other site
563174000847	RPB1 interaction site [polypeptide binding]; other site
563174000848	RPB11 interaction site [polypeptide binding]; other site
563174000849	RPB3 interaction site [polypeptide binding]; other site
563174000850	RPB12 interaction site [polypeptide binding]; other site
563174000851	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
563174000852	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
563174000853	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
563174000854	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
563174000855	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
563174000856	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
563174000857	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
563174000858	G-loop; other site
563174000859	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
563174000860	DNA binding site [nucleotide binding]
563174000861	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
563174000862	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
563174000863	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174000864	active site
563174000865	motif I; other site
563174000866	motif II; other site
563174000867	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
563174000868	beta-galactosidase; Region: BGL; TIGR03356
563174000869	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
563174000870	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
563174000871	metal binding site [ion binding]; metal-binding site
563174000872	dimer interface [polypeptide binding]; other site
563174000873	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
563174000874	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
563174000875	putative Zn2+ binding site [ion binding]; other site
563174000876	putative DNA binding site [nucleotide binding]; other site
563174000877	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
563174000878	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
563174000879	Zn binding site [ion binding]; other site
563174000880	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
563174000881	Zn binding site [ion binding]; other site
563174000882	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
563174000883	catalytic core [active]
563174000884	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
563174000885	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
563174000886	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
563174000887	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174000888	dimer interface [polypeptide binding]; other site
563174000889	conserved gate region; other site
563174000890	ABC-ATPase subunit interface; other site
563174000891	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
563174000892	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
563174000893	Leucine-rich repeats; other site
563174000894	Substrate binding site [chemical binding]; other site
563174000895	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
563174000896	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
563174000897	beta-galactosidase; Region: BGL; TIGR03356
563174000898	sugar phosphate phosphatase; Provisional; Region: PRK10513
563174000899	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174000900	active site
563174000901	motif I; other site
563174000902	motif II; other site
563174000903	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
563174000904	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174000905	Coenzyme A binding pocket [chemical binding]; other site
563174000906	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174000907	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
563174000908	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
563174000909	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
563174000910	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174000911	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
563174000912	active site
563174000913	motif I; other site
563174000914	motif II; other site
563174000915	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174000916	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
563174000917	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
563174000918	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
563174000919	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
563174000920	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
563174000921	Walker A/P-loop; other site
563174000922	ATP binding site [chemical binding]; other site
563174000923	Q-loop/lid; other site
563174000924	ABC transporter signature motif; other site
563174000925	Walker B; other site
563174000926	D-loop; other site
563174000927	H-loop/switch region; other site
563174000928	TOBE domain; Region: TOBE; pfam03459
563174000929	ATP cone domain; Region: ATP-cone; pfam03477
563174000930	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
563174000931	Class III ribonucleotide reductase; Region: RNR_III; cd01675
563174000932	effector binding site; other site
563174000933	active site
563174000934	Zn binding site [ion binding]; other site
563174000935	glycine loop; other site
563174000936	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
563174000937	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
563174000938	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
563174000939	CitB domain protein; Region: CitB; TIGR02484
563174000940	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174000941	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
563174000942	Predicted amidohydrolase [General function prediction only]; Region: COG0388
563174000943	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
563174000944	putative active site [active]
563174000945	catalytic triad [active]
563174000946	putative dimer interface [polypeptide binding]; other site
563174000947	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174000948	dimer interface [polypeptide binding]; other site
563174000949	conserved gate region; other site
563174000950	ABC-ATPase subunit interface; other site
563174000951	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
563174000952	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
563174000953	Walker A/P-loop; other site
563174000954	ATP binding site [chemical binding]; other site
563174000955	Q-loop/lid; other site
563174000956	ABC transporter signature motif; other site
563174000957	Walker B; other site
563174000958	D-loop; other site
563174000959	H-loop/switch region; other site
563174000960	NIL domain; Region: NIL; pfam09383
563174000961	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
563174000962	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
563174000963	transaminase; Reviewed; Region: PRK08068
563174000964	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
563174000965	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174000966	homodimer interface [polypeptide binding]; other site
563174000967	catalytic residue [active]
563174000968	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
563174000969	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174000970	active site
563174000971	phosphorylation site [posttranslational modification]
563174000972	intermolecular recognition site; other site
563174000973	dimerization interface [polypeptide binding]; other site
563174000974	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
563174000975	DNA binding site [nucleotide binding]
563174000976	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
563174000977	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
563174000978	dimerization interface [polypeptide binding]; other site
563174000979	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
563174000980	putative active site [active]
563174000981	heme pocket [chemical binding]; other site
563174000982	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
563174000983	dimer interface [polypeptide binding]; other site
563174000984	phosphorylation site [posttranslational modification]
563174000985	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174000986	ATP binding site [chemical binding]; other site
563174000987	Mg2+ binding site [ion binding]; other site
563174000988	G-X-G motif; other site
563174000989	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
563174000990	YycH protein; Region: YycH; pfam07435
563174000991	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853
563174000992	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
563174000993	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
563174000994	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
563174000995	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
563174000996	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
563174000997	protein binding site [polypeptide binding]; other site
563174000998	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
563174000999	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
563174001000	HTH domain; Region: HTH_11; pfam08279
563174001001	Mga helix-turn-helix domain; Region: Mga; pfam05043
563174001002	PRD domain; Region: PRD; pfam00874
563174001003	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
563174001004	active site
563174001005	P-loop; other site
563174001006	phosphorylation site [posttranslational modification]
563174001007	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174001008	active site
563174001009	phosphorylation site [posttranslational modification]
563174001010	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
563174001011	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
563174001012	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
563174001013	active site
563174001014	P-loop; other site
563174001015	phosphorylation site [posttranslational modification]
563174001016	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
563174001017	beta-galactosidase; Region: BGL; TIGR03356
563174001018	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
563174001019	methionine cluster; other site
563174001020	active site
563174001021	phosphorylation site [posttranslational modification]
563174001022	metal binding site [ion binding]; metal-binding site
563174001023	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
563174001024	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
563174001025	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
563174001026	catalytic residue [active]
563174001027	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
563174001028	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
563174001029	nucleophilic elbow; other site
563174001030	catalytic triad; other site
563174001031	Uncharacterized conserved protein [Function unknown]; Region: COG1479
563174001032	Protein of unknown function DUF262; Region: DUF262; pfam03235
563174001033	Protein of unknown function DUF262; Region: DUF262; pfam03235
563174001034	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
563174001035	NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521
563174001036	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
563174001037	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
563174001038	cofactor binding site; other site
563174001039	DNA binding site [nucleotide binding]
563174001040	substrate interaction site [chemical binding]; other site
563174001041	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805
563174001042	putative active site [active]
563174001043	YdjC motif; other site
563174001044	Mg binding site [ion binding]; other site
563174001045	putative homodimer interface [polypeptide binding]; other site
563174001046	Putative transcription activator [Transcription]; Region: TenA; COG0819
563174001047	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
563174001048	substrate binding site [chemical binding]; other site
563174001049	multimerization interface [polypeptide binding]; other site
563174001050	ATP binding site [chemical binding]; other site
563174001051	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
563174001052	dimer interface [polypeptide binding]; other site
563174001053	substrate binding site [chemical binding]; other site
563174001054	ATP binding site [chemical binding]; other site
563174001055	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
563174001056	thiamine phosphate binding site [chemical binding]; other site
563174001057	active site
563174001058	pyrophosphate binding site [ion binding]; other site
563174001059	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
563174001060	beta-galactosidase; Region: BGL; TIGR03356
563174001061	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
563174001062	Protein of unknown function (DUF1696); Region: DUF1696; pfam08000
563174001063	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
563174001064	putative catalytic site [active]
563174001065	putative metal binding site [ion binding]; other site
563174001066	putative phosphate binding site [ion binding]; other site
563174001067	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174001068	non-specific DNA binding site [nucleotide binding]; other site
563174001069	salt bridge; other site
563174001070	sequence-specific DNA binding site [nucleotide binding]; other site
563174001071	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
563174001072	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174001073	non-specific DNA binding site [nucleotide binding]; other site
563174001074	salt bridge; other site
563174001075	sequence-specific DNA binding site [nucleotide binding]; other site
563174001076	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
563174001077	Leucine rich repeat; Region: LRR_8; pfam13855
563174001078	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001079	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001080	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001081	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001082	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001083	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001084	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001085	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001086	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001087	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001088	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001089	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001090	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001091	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001092	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
563174001093	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
563174001094	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
563174001095	Leucine rich repeat; Region: LRR_8; pfam13855
563174001096	Leucine rich repeat; Region: LRR_8; pfam13855
563174001097	Leucine rich repeat; Region: LRR_8; pfam13855
563174001098	Leucine rich repeat; Region: LRR_8; pfam13855
563174001099	LRR adjacent; Region: LRR_adjacent; pfam08191
563174001100	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174001101	Protein of unknown function (DUF3130; Region: DUF3130; pfam11328
563174001102	LXG domain of WXG superfamily; Region: LXG; pfam04740
563174001103	Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221
563174001104	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
563174001105	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
563174001106	TPP-binding site [chemical binding]; other site
563174001107	dimer interface [polypeptide binding]; other site
563174001108	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
563174001109	PYR/PP interface [polypeptide binding]; other site
563174001110	dimer interface [polypeptide binding]; other site
563174001111	TPP binding site [chemical binding]; other site
563174001112	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
563174001113	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
563174001114	active site
563174001115	intersubunit interactions; other site
563174001116	catalytic residue [active]
563174001117	short chain dehydrogenase; Provisional; Region: PRK06841
563174001118	classical (c) SDRs; Region: SDR_c; cd05233
563174001119	NAD(P) binding site [chemical binding]; other site
563174001120	active site
563174001121	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
563174001122	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
563174001123	substrate binding site [chemical binding]; other site
563174001124	dimer interface [polypeptide binding]; other site
563174001125	catalytic triad [active]
563174001126	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
563174001127	DAK2 domain; Region: Dak2; cl03685
563174001128	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
563174001129	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
563174001130	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
563174001131	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
563174001132	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
563174001133	putative DNA binding site [nucleotide binding]; other site
563174001134	putative Zn2+ binding site [ion binding]; other site
563174001135	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
563174001136	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174001137	Coenzyme A binding pocket [chemical binding]; other site
563174001138	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
563174001139	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
563174001140	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
563174001141	Leucine-rich repeats; other site
563174001142	LRR adjacent; Region: LRR_adjacent; pfam08191
563174001143	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174001144	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174001145	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
563174001146	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
563174001147	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
563174001148	acyl-activating enzyme (AAE) consensus motif; other site
563174001149	acyl-activating enzyme (AAE) consensus motif; other site
563174001150	AMP binding site [chemical binding]; other site
563174001151	active site
563174001152	CoA binding site [chemical binding]; other site
563174001153	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
563174001154	L-aspartate oxidase; Provisional; Region: PRK06175
563174001155	putative oxidoreductase; Provisional; Region: PRK10206
563174001156	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
563174001157	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
563174001158	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174001159	active site
563174001160	phosphorylation site [posttranslational modification]
563174001161	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
563174001162	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
563174001163	active site
563174001164	P-loop; other site
563174001165	phosphorylation site [posttranslational modification]
563174001166	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
563174001167	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
563174001168	intersubunit interface [polypeptide binding]; other site
563174001169	active site
563174001170	zinc binding site [ion binding]; other site
563174001171	Na+ binding site [ion binding]; other site
563174001172	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
563174001173	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
563174001174	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
563174001175	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
563174001176	conserved cys residue [active]
563174001177	Predicted transcriptional regulator [Transcription]; Region: COG2378
563174001178	HTH domain; Region: HTH_11; pfam08279
563174001179	WYL domain; Region: WYL; pfam13280
563174001180	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693
563174001181	nudix motif; other site
563174001182	hypothetical protein; Provisional; Region: PRK12378
563174001183	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
563174001184	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
563174001185	PhnA protein; Region: PhnA; pfam03831
563174001186	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
563174001187	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174001188	DNA-binding site [nucleotide binding]; DNA binding site
563174001189	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
563174001190	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
563174001191	beta-galactosidase; Region: BGL; TIGR03356
563174001192	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
563174001193	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
563174001194	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
563174001195	active site
563174001196	P-loop; other site
563174001197	phosphorylation site [posttranslational modification]
563174001198	Predicted transcriptional regulator [Transcription]; Region: COG2378
563174001199	HTH domain; Region: HTH_11; pfam08279
563174001200	WYL domain; Region: WYL; pfam13280
563174001201	Protein of unknown function (DUF3130; Region: DUF3130; pfam11328
563174001202	LXG domain of WXG superfamily; Region: LXG; pfam04740
563174001203	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
563174001204	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
563174001205	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
563174001206	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
563174001207	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
563174001208	tetrameric interface [polypeptide binding]; other site
563174001209	NAD binding site [chemical binding]; other site
563174001210	catalytic residues [active]
563174001211	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
563174001212	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
563174001213	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
563174001214	substrate binding site [chemical binding]; other site
563174001215	ATP binding site [chemical binding]; other site
563174001216	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
563174001217	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
563174001218	PYR/PP interface [polypeptide binding]; other site
563174001219	dimer interface [polypeptide binding]; other site
563174001220	TPP binding site [chemical binding]; other site
563174001221	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
563174001222	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
563174001223	TPP-binding site; other site
563174001224	Uncharacterized conserved protein [Function unknown]; Region: COG5646
563174001225	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
563174001226	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
563174001227	ligand binding site [chemical binding]; other site
563174001228	active site
563174001229	UGI interface [polypeptide binding]; other site
563174001230	catalytic site [active]
563174001231	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
563174001232	hypothetical protein; Provisional; Region: PRK13665
563174001233	Bacterial SH3 domain; Region: SH3_3; cl17532
563174001234	NlpC/P60 family; Region: NLPC_P60; pfam00877
563174001235	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
563174001236	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174001237	Coenzyme A binding pocket [chemical binding]; other site
563174001238	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
563174001239	pyrroline-5-carboxylate reductase; Region: PLN02688
563174001240	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
563174001241	putative hydrophobic ligand binding site [chemical binding]; other site
563174001242	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174001243	active site
563174001244	phosphorylation site [posttranslational modification]
563174001245	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
563174001246	active site
563174001247	P-loop; other site
563174001248	phosphorylation site [posttranslational modification]
563174001249	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
563174001250	alpha-mannosidase; Provisional; Region: PRK09819
563174001251	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
563174001252	active site
563174001253	metal binding site [ion binding]; metal-binding site
563174001254	catalytic site [active]
563174001255	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
563174001256	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
563174001257	HTH domain; Region: HTH_11; pfam08279
563174001258	Mga helix-turn-helix domain; Region: Mga; pfam05043
563174001259	PRD domain; Region: PRD; pfam00874
563174001260	PRD domain; Region: PRD; pfam00874
563174001261	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
563174001262	active site
563174001263	P-loop; other site
563174001264	phosphorylation site [posttranslational modification]
563174001265	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174001266	active site
563174001267	phosphorylation site [posttranslational modification]
563174001268	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
563174001269	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
563174001270	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
563174001271	putative metal binding site [ion binding]; other site
563174001272	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835
563174001273	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
563174001274	trimer interface [polypeptide binding]; other site
563174001275	phosphoenolpyruvate synthase; Validated; Region: PRK06241
563174001276	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
563174001277	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
563174001278	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
563174001279	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
563174001280	Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954
563174001281	NodB motif; other site
563174001282	active site
563174001283	catalytic site [active]
563174001284	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174001285	salt bridge; other site
563174001286	non-specific DNA binding site [nucleotide binding]; other site
563174001287	sequence-specific DNA binding site [nucleotide binding]; other site
563174001288	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174001289	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
563174001290	active site
563174001291	motif I; other site
563174001292	motif II; other site
563174001293	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174001294	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
563174001295	lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416
563174001296	Predicted transcriptional regulators [Transcription]; Region: COG1695
563174001297	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
563174001298	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
563174001299	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
563174001300	DNA binding residues [nucleotide binding]
563174001301	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
563174001302	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
563174001303	HTH domain; Region: HTH_11; pfam08279
563174001304	PRD domain; Region: PRD; pfam00874
563174001305	PRD domain; Region: PRD; pfam00874
563174001306	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
563174001307	active site
563174001308	P-loop; other site
563174001309	phosphorylation site [posttranslational modification]
563174001310	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174001311	active site
563174001312	phosphorylation site [posttranslational modification]
563174001313	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174001314	active site
563174001315	phosphorylation site [posttranslational modification]
563174001316	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
563174001317	active site
563174001318	P-loop; other site
563174001319	phosphorylation site [posttranslational modification]
563174001320	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
563174001321	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
563174001322	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
563174001323	active site
563174001324	metal binding site [ion binding]; metal-binding site
563174001325	catalytic site [active]
563174001326	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
563174001327	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
563174001328	Transcriptional regulator [Transcription]; Region: LysR; COG0583
563174001329	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
563174001330	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
563174001331	dimerization interface [polypeptide binding]; other site
563174001332	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
563174001333	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
563174001334	active site
563174001335	substrate binding site [chemical binding]; other site
563174001336	trimer interface [polypeptide binding]; other site
563174001337	CoA binding site [chemical binding]; other site
563174001338	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
563174001339	classical (c) SDRs; Region: SDR_c; cd05233
563174001340	NAD(P) binding site [chemical binding]; other site
563174001341	active site
563174001342	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
563174001343	RHS Repeat; Region: RHS_repeat; pfam05593
563174001344	RHS Repeat; Region: RHS_repeat; cl11982
563174001345	RHS Repeat; Region: RHS_repeat; pfam05593
563174001346	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
563174001347	RHS Repeat; Region: RHS_repeat; pfam05593
563174001348	RHS Repeat; Region: RHS_repeat; pfam05593
563174001349	RHS Repeat; Region: RHS_repeat; pfam05593
563174001350	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
563174001351	HEAT repeats; Region: HEAT_2; pfam13646
563174001352	HEAT repeats; Region: HEAT_2; pfam13646
563174001353	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
563174001354	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
563174001355	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
563174001356	Substrate binding site [chemical binding]; other site
563174001357	LRR adjacent; Region: LRR_adjacent; pfam08191
563174001358	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174001359	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174001360	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174001361	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
563174001362	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
563174001363	Leucine rich repeat; Region: LRR_8; pfam13855
563174001364	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
563174001365	Leucine rich repeat; Region: LRR_8; pfam13855
563174001366	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
563174001367	LRR adjacent; Region: LRR_adjacent; pfam08191
563174001368	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174001369	SH3-like domain; Region: SH3_8; pfam13457
563174001370	Predicted transcriptional regulator [Transcription]; Region: COG1959
563174001371	Transcriptional regulator; Region: Rrf2; pfam02082
563174001372	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
563174001373	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
563174001374	NAD(P) binding site [chemical binding]; other site
563174001375	active site
563174001376	nickel responsive regulator; Provisional; Region: PRK02967
563174001377	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
563174001378	Protein of unknown function (DUF2004); Region: DUF2004; pfam09406
563174001379	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
563174001380	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
563174001381	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
563174001382	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
563174001383	Transcriptional regulator [Transcription]; Region: LytR; COG1316
563174001384	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
563174001385	Predicted membrane protein [Function unknown]; Region: COG3619
563174001386	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
563174001387	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
563174001388	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
563174001389	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
563174001390	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
563174001391	Protein of unknown function DUF58; Region: DUF58; pfam01882
563174001392	MoxR-like ATPases [General function prediction only]; Region: COG0714
563174001393	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174001394	Walker A motif; other site
563174001395	ATP binding site [chemical binding]; other site
563174001396	Walker B motif; other site
563174001397	arginine finger; other site
563174001398	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
563174001399	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
563174001400	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
563174001401	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
563174001402	Na binding site [ion binding]; other site
563174001403	Uncharacterized conserved protein [Function unknown]; Region: COG3535
563174001404	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
563174001405	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
563174001406	nucleotide binding site [chemical binding]; other site
563174001407	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
563174001408	Mga helix-turn-helix domain; Region: Mga; pfam05043
563174001409	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
563174001410	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
563174001411	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
563174001412	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
563174001413	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
563174001414	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
563174001415	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
563174001416	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
563174001417	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
563174001418	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
563174001419	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
563174001420	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174001421	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
563174001422	Zn2+ binding site [ion binding]; other site
563174001423	Mg2+ binding site [ion binding]; other site
563174001424	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
563174001425	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
563174001426	Myosin-crossreactive antigen [Function unknown]; Region: COG4716
563174001427	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
563174001428	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
563174001429	FeS/SAM binding site; other site
563174001430	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
563174001431	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316
563174001432	LXG domain of WXG superfamily; Region: LXG; pfam04740
563174001433	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
563174001434	putative FMN binding site [chemical binding]; other site
563174001435	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
563174001436	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
563174001437	nudix motif; other site
563174001438	Transcriptional regulator [Transcription]; Region: LysR; COG0583
563174001439	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
563174001440	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
563174001441	putative dimerization interface [polypeptide binding]; other site
563174001442	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
563174001443	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
563174001444	active site
563174001445	FMN binding site [chemical binding]; other site
563174001446	substrate binding site [chemical binding]; other site
563174001447	putative catalytic residue [active]
563174001448	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
563174001449	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
563174001450	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
563174001451	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
563174001452	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
563174001453	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
563174001454	shikimate binding site; other site
563174001455	NAD(P) binding site [chemical binding]; other site
563174001456	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
563174001457	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
563174001458	active site
563174001459	catalytic residue [active]
563174001460	dimer interface [polypeptide binding]; other site
563174001461	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
563174001462	active site
563174001463	catalytic triad [active]
563174001464	oxyanion hole [active]
563174001465	EamA-like transporter family; Region: EamA; pfam00892
563174001466	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
563174001467	EamA-like transporter family; Region: EamA; pfam00892
563174001468	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
563174001469	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
563174001470	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
563174001471	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
563174001472	substrate binding site [chemical binding]; other site
563174001473	hexamer interface [polypeptide binding]; other site
563174001474	metal binding site [ion binding]; metal-binding site
563174001475	Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176
563174001476	catalytic residue [active]
563174001477	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
563174001478	PRD domain; Region: PRD; pfam00874
563174001479	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
563174001480	active site
563174001481	P-loop; other site
563174001482	phosphorylation site [posttranslational modification]
563174001483	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174001484	active site
563174001485	phosphorylation site [posttranslational modification]
563174001486	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
563174001487	putative active site [active]
563174001488	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174001489	active site
563174001490	phosphorylation site [posttranslational modification]
563174001491	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
563174001492	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
563174001493	substrate binding site [chemical binding]; other site
563174001494	hexamer interface [polypeptide binding]; other site
563174001495	metal binding site [ion binding]; metal-binding site
563174001496	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
563174001497	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
563174001498	putative NAD(P) binding site [chemical binding]; other site
563174001499	catalytic Zn binding site [ion binding]; other site
563174001500	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
563174001501	active site
563174001502	P-loop; other site
563174001503	phosphorylation site [posttranslational modification]
563174001504	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
563174001505	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
563174001506	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
563174001507	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
563174001508	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
563174001509	active site
563174001510	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349
563174001511	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
563174001512	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
563174001513	catalytic triad [active]
563174001514	conserved hypothetical protein; Region: lin0512_fam; TIGR02058
563174001515	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
563174001516	MarR family; Region: MarR_2; pfam12802
563174001517	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
563174001518	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
563174001519	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
563174001520	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
563174001521	Ligand Binding Site [chemical binding]; other site
563174001522	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
563174001523	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
563174001524	putative active site [active]
563174001525	putative metal binding site [ion binding]; other site
563174001526	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
563174001527	catalytic core [active]
563174001528	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
563174001529	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
563174001530	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754
563174001531	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909
563174001532	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
563174001533	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
563174001534	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
563174001535	CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203
563174001536	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
563174001537	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
563174001538	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
563174001539	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
563174001540	Predicted membrane protein [Function unknown]; Region: COG3759
563174001541	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174001542	Major Facilitator Superfamily; Region: MFS_1; pfam07690
563174001543	putative substrate translocation pore; other site
563174001544	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
563174001545	non-specific DNA interactions [nucleotide binding]; other site
563174001546	DNA binding site [nucleotide binding]
563174001547	sequence specific DNA binding site [nucleotide binding]; other site
563174001548	putative cAMP binding site [chemical binding]; other site
563174001549	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
563174001550	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
563174001551	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
563174001552	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
563174001553	NAD binding site [chemical binding]; other site
563174001554	sugar binding site [chemical binding]; other site
563174001555	divalent metal binding site [ion binding]; other site
563174001556	tetramer (dimer of dimers) interface [polypeptide binding]; other site
563174001557	dimer interface [polypeptide binding]; other site
563174001558	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
563174001559	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
563174001560	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
563174001561	putative active site [active]
563174001562	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
563174001563	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
563174001564	Sulfate transporter family; Region: Sulfate_transp; pfam00916
563174001565	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
563174001566	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
563174001567	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
563174001568	DNA binding residues [nucleotide binding]
563174001569	dimer interface [polypeptide binding]; other site
563174001570	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
563174001571	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
563174001572	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
563174001573	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
563174001574	DXD motif; other site
563174001575	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
563174001576	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
563174001577	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
563174001578	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
563174001579	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174001580	S-adenosylmethionine binding site [chemical binding]; other site
563174001581	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
563174001582	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
563174001583	Transcriptional regulators [Transcription]; Region: PurR; COG1609
563174001584	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
563174001585	DNA binding site [nucleotide binding]
563174001586	domain linker motif; other site
563174001587	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
563174001588	putative dimerization interface [polypeptide binding]; other site
563174001589	putative ligand binding site [chemical binding]; other site
563174001590	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
563174001591	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
563174001592	NAD binding site [chemical binding]; other site
563174001593	sugar binding site [chemical binding]; other site
563174001594	divalent metal binding site [ion binding]; other site
563174001595	tetramer (dimer of dimers) interface [polypeptide binding]; other site
563174001596	dimer interface [polypeptide binding]; other site
563174001597	allantoate amidohydrolase; Reviewed; Region: PRK09290
563174001598	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
563174001599	active site
563174001600	metal binding site [ion binding]; metal-binding site
563174001601	dimer interface [polypeptide binding]; other site
563174001602	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
563174001603	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
563174001604	metal binding site [ion binding]; metal-binding site
563174001605	putative dimer interface [polypeptide binding]; other site
563174001606	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
563174001607	Beta-lactamase; Region: Beta-lactamase; pfam00144
563174001608	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
563174001609	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
563174001610	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
563174001611	intersubunit interface [polypeptide binding]; other site
563174001612	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
563174001613	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
563174001614	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
563174001615	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
563174001616	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
563174001617	Glucitol operon activator protein (GutM); Region: GutM; cl01890
563174001618	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
563174001619	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
563174001620	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
563174001621	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
563174001622	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
563174001623	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174001624	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
563174001625	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
563174001626	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
563174001627	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
563174001628	WxL domain surface cell wall-binding; Region: WxL; pfam13731
563174001629	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
563174001630	WxL domain surface cell wall-binding; Region: WxL; pfam13731
563174001631	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
563174001632	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
563174001633	FOG: CBS domain [General function prediction only]; Region: COG0517
563174001634	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
563174001635	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
563174001636	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
563174001637	dimer interface [polypeptide binding]; other site
563174001638	active site
563174001639	metal binding site [ion binding]; metal-binding site
563174001640	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
563174001641	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174001642	putative substrate translocation pore; other site
563174001643	POT family; Region: PTR2; pfam00854
563174001644	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
563174001645	catalytic core [active]
563174001646	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
563174001647	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
563174001648	catalytic core [active]
563174001649	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
563174001650	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
563174001651	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
563174001652	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
563174001653	Cl binding site [ion binding]; other site
563174001654	oligomer interface [polypeptide binding]; other site
563174001655	glutamate dehydrogenase; Provisional; Region: PRK09414
563174001656	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
563174001657	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
563174001658	NAD(P) binding site [chemical binding]; other site
563174001659	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
563174001660	metal binding site [ion binding]; metal-binding site
563174001661	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
563174001662	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
563174001663	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
563174001664	substrate binding site [chemical binding]; other site
563174001665	glutamase interaction surface [polypeptide binding]; other site
563174001666	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
563174001667	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
563174001668	catalytic residues [active]
563174001669	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
563174001670	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
563174001671	putative active site [active]
563174001672	oxyanion strand; other site
563174001673	catalytic triad [active]
563174001674	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
563174001675	putative active site pocket [active]
563174001676	4-fold oligomerization interface [polypeptide binding]; other site
563174001677	metal binding residues [ion binding]; metal-binding site
563174001678	3-fold/trimer interface [polypeptide binding]; other site
563174001679	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
563174001680	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
563174001681	NAD binding site [chemical binding]; other site
563174001682	dimerization interface [polypeptide binding]; other site
563174001683	product binding site; other site
563174001684	substrate binding site [chemical binding]; other site
563174001685	zinc binding site [ion binding]; other site
563174001686	catalytic residues [active]
563174001687	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
563174001688	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
563174001689	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
563174001690	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
563174001691	dimer interface [polypeptide binding]; other site
563174001692	motif 1; other site
563174001693	active site
563174001694	motif 2; other site
563174001695	motif 3; other site
563174001696	histidinol-phosphatase; Reviewed; Region: PRK08123
563174001697	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
563174001698	active site
563174001699	dimer interface [polypeptide binding]; other site
563174001700	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
563174001701	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
563174001702	DNA binding site [nucleotide binding]
563174001703	active site
563174001704	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
563174001705	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
563174001706	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
563174001707	beta-galactosidase; Region: BGL; TIGR03356
563174001708	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
563174001709	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174001710	DNA-binding site [nucleotide binding]; DNA binding site
563174001711	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
563174001712	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001713	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174001714	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
563174001715	Uncharacterized conserved protein [Function unknown]; Region: COG2966
563174001716	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
563174001717	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
563174001718	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
563174001719	Predicted esterase [General function prediction only]; Region: COG0400
563174001720	putative hydrolase; Provisional; Region: PRK11460
563174001721	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
563174001722	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
563174001723	putative RNA binding site [nucleotide binding]; other site
563174001724	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174001725	S-adenosylmethionine binding site [chemical binding]; other site
563174001726	invasion associated secreted endopeptidase; Provisional; Region: PRK13914
563174001727	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
563174001728	Bacterial SH3 domain; Region: SH3_3; pfam08239
563174001729	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
563174001730	NlpC/P60 family; Region: NLPC_P60; pfam00877
563174001731	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
563174001732	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
563174001733	ATP binding site [chemical binding]; other site
563174001734	putative Mg++ binding site [ion binding]; other site
563174001735	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
563174001736	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
563174001737	nucleotide binding region [chemical binding]; other site
563174001738	ATP-binding site [chemical binding]; other site
563174001739	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
563174001740	Domain of unknown function DUF20; Region: UPF0118; pfam01594
563174001741	WxL domain surface cell wall-binding; Region: WxL; pfam13731
563174001742	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
563174001743	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
563174001744	UreD urease accessory protein; Region: UreD; cl00530
563174001745	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
563174001746	DNA photolyase; Region: DNA_photolyase; pfam00875
563174001747	Predicted membrane protein [Function unknown]; Region: COG4852
563174001748	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
563174001749	DAK2 domain; Region: Dak2; pfam02734
563174001750	EDD domain protein, DegV family; Region: DegV; TIGR00762
563174001751	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
563174001752	Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752
563174001753	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
563174001754	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
563174001755	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
563174001756	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
563174001757	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
563174001758	homodimer interface [polypeptide binding]; other site
563174001759	substrate-cofactor binding pocket; other site
563174001760	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174001761	catalytic residue [active]
563174001762	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
563174001763	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
563174001764	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174001765	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
563174001766	ligand binding site [chemical binding]; other site
563174001767	flexible hinge region; other site
563174001768	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
563174001769	non-specific DNA interactions [nucleotide binding]; other site
563174001770	DNA binding site [nucleotide binding]
563174001771	sequence specific DNA binding site [nucleotide binding]; other site
563174001772	putative cAMP binding site [chemical binding]; other site
563174001773	BioY family; Region: BioY; pfam02632
563174001774	Predicted transcriptional regulators [Transcription]; Region: COG1695
563174001775	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
563174001776	Predicted membrane protein [Function unknown]; Region: COG4709
563174001777	Uncharacterized conserved protein [Function unknown]; Region: COG3595
563174001778	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
563174001779	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
563174001780	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
563174001781	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
563174001782	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174001783	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
563174001784	Coenzyme A binding pocket [chemical binding]; other site
563174001785	Tic20-like protein; Region: Tic20; pfam09685
563174001786	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
563174001787	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
563174001788	Transcriptional regulators [Transcription]; Region: MarR; COG1846
563174001789	MarR family; Region: MarR_2; pfam12802
563174001790	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
563174001791	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
563174001792	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174001793	Walker A/P-loop; other site
563174001794	ATP binding site [chemical binding]; other site
563174001795	Q-loop/lid; other site
563174001796	ABC transporter signature motif; other site
563174001797	Walker B; other site
563174001798	D-loop; other site
563174001799	H-loop/switch region; other site
563174001800	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
563174001801	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
563174001802	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
563174001803	Walker A/P-loop; other site
563174001804	ATP binding site [chemical binding]; other site
563174001805	Q-loop/lid; other site
563174001806	ABC transporter signature motif; other site
563174001807	Walker B; other site
563174001808	D-loop; other site
563174001809	H-loop/switch region; other site
563174001810	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
563174001811	active site residue [active]
563174001812	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
563174001813	Leucine rich repeat; Region: LRR_8; pfam13855
563174001814	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
563174001815	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
563174001816	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
563174001817	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
563174001818	Transcriptional regulators [Transcription]; Region: MarR; COG1846
563174001819	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
563174001820	putative DNA binding site [nucleotide binding]; other site
563174001821	putative Zn2+ binding site [ion binding]; other site
563174001822	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
563174001823	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
563174001824	putative NAD(P) binding site [chemical binding]; other site
563174001825	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
563174001826	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
563174001827	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
563174001828	putative active site [active]
563174001829	catalytic site [active]
563174001830	putative metal binding site [ion binding]; other site
563174001831	Catalytic domain of Protein Kinases; Region: PKc; cd00180
563174001832	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
563174001833	active site
563174001834	ATP binding site [chemical binding]; other site
563174001835	substrate binding site [chemical binding]; other site
563174001836	activation loop (A-loop); other site
563174001837	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
563174001838	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
563174001839	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
563174001840	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
563174001841	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174001842	Coenzyme A binding pocket [chemical binding]; other site
563174001843	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
563174001844	active site
563174001845	catalytic triad [active]
563174001846	oxyanion hole [active]
563174001847	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
563174001848	domain interaction interfaces [polypeptide binding]; other site
563174001849	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
563174001850	domain interaction interfaces [polypeptide binding]; other site
563174001851	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
563174001852	domain interaction interfaces [polypeptide binding]; other site
563174001853	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
563174001854	domain interaction interfaces [polypeptide binding]; other site
563174001855	Isochorismatase family; Region: Isochorismatase; pfam00857
563174001856	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
563174001857	catalytic triad [active]
563174001858	conserved cis-peptide bond; other site
563174001859	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
563174001860	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174001861	motif II; other site
563174001862	Predicted transcriptional regulator [Transcription]; Region: COG1959
563174001863	Transcriptional regulator; Region: Rrf2; pfam02082
563174001864	Methyltransferase domain; Region: Methyltransf_31; pfam13847
563174001865	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174001866	S-adenosylmethionine binding site [chemical binding]; other site
563174001867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
563174001868	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
563174001869	Domain of unknown function (DUF1768); Region: DUF1768; cl01271
563174001870	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
563174001871	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
563174001872	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
563174001873	active site
563174001874	catalytic tetrad [active]
563174001875	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
563174001876	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
563174001877	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174001878	motif II; other site
563174001879	Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176
563174001880	catalytic residue [active]
563174001881	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
563174001882	Sulfatase; Region: Sulfatase; pfam00884
563174001883	amino acid transporter; Region: 2A0306; TIGR00909
563174001884	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
563174001885	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
563174001886	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
563174001887	putative metal binding site [ion binding]; other site
563174001888	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
563174001889	active site
563174001890	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
563174001891	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
563174001892	Cl binding site [ion binding]; other site
563174001893	oligomer interface [polypeptide binding]; other site
563174001894	Transcriptional regulators [Transcription]; Region: GntR; COG1802
563174001895	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174001896	DNA-binding site [nucleotide binding]; DNA binding site
563174001897	Predicted membrane protein [Function unknown]; Region: COG1511
563174001898	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
563174001899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174001900	Transcriptional regulators [Transcription]; Region: GntR; COG1802
563174001901	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174001902	DNA-binding site [nucleotide binding]; DNA binding site
563174001903	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
563174001904	Predicted integral membrane protein [Function unknown]; Region: COG5523
563174001905	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
563174001906	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
563174001907	active site
563174001908	metal binding site [ion binding]; metal-binding site
563174001909	Predicted membrane protein [Function unknown]; Region: COG2322
563174001910	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
563174001911	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
563174001912	minor groove reading motif; other site
563174001913	helix-hairpin-helix signature motif; other site
563174001914	substrate binding pocket [chemical binding]; other site
563174001915	active site
563174001916	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174001917	non-specific DNA binding site [nucleotide binding]; other site
563174001918	salt bridge; other site
563174001919	sequence-specific DNA binding site [nucleotide binding]; other site
563174001920	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
563174001921	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
563174001922	Transposase; Region: HTH_Tnp_1; cl17663
563174001923	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
563174001924	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
563174001925	dimer interface [polypeptide binding]; other site
563174001926	substrate binding site [chemical binding]; other site
563174001927	ATP binding site [chemical binding]; other site
563174001928	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
563174001929	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174001930	active site
563174001931	motif I; other site
563174001932	motif II; other site
563174001933	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
563174001934	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174001935	maltose O-acetyltransferase; Provisional; Region: PRK10092
563174001936	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
563174001937	active site
563174001938	substrate binding site [chemical binding]; other site
563174001939	trimer interface [polypeptide binding]; other site
563174001940	CoA binding site [chemical binding]; other site
563174001941	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
563174001942	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
563174001943	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
563174001944	Walker A/P-loop; other site
563174001945	ATP binding site [chemical binding]; other site
563174001946	Q-loop/lid; other site
563174001947	ABC transporter signature motif; other site
563174001948	Walker B; other site
563174001949	D-loop; other site
563174001950	H-loop/switch region; other site
563174001951	inner membrane transport permease; Provisional; Region: PRK15066
563174001952	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
563174001953	oxidoreductase; Provisional; Region: PRK07985
563174001954	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
563174001955	NAD(P) binding site [chemical binding]; other site
563174001956	active site
563174001957	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
563174001958	Protein of unknown function (DUF805); Region: DUF805; pfam05656
563174001959	Predicted membrane protein [Function unknown]; Region: COG3152
563174001960	DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181
563174001961	Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338
563174001962	Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987
563174001963	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
563174001964	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
563174001965	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
563174001966	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298
563174001967	FHIPEP family; Region: FHIPEP; pfam00771
563174001968	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726
563174001969	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
563174001970	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819
563174001971	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
563174001972	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
563174001973	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
563174001974	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
563174001975	Protein of unknown function (DUF3964); Region: DUF3964; pfam13107
563174001976	flagellar motor protein MotA; Validated; Region: PRK08124
563174001977	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
563174001978	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
563174001979	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
563174001980	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
563174001981	ligand binding site [chemical binding]; other site
563174001982	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
563174001983	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
563174001984	putative metal binding site; other site
563174001985	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
563174001986	binding surface
563174001987	TPR motif; other site
563174001988	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
563174001989	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
563174001990	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174001991	active site
563174001992	phosphorylation site [posttranslational modification]
563174001993	intermolecular recognition site; other site
563174001994	dimerization interface [polypeptide binding]; other site
563174001995	flagellin; Provisional; Region: PRK12805
563174001996	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
563174001997	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
563174001998	Response regulator receiver domain; Region: Response_reg; pfam00072
563174001999	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174002000	active site
563174002001	phosphorylation site [posttranslational modification]
563174002002	intermolecular recognition site; other site
563174002003	dimerization interface [polypeptide binding]; other site
563174002004	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
563174002005	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
563174002006	putative binding surface; other site
563174002007	active site
563174002008	P2 response regulator binding domain; Region: P2; pfam07194
563174002009	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
563174002010	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174002011	ATP binding site [chemical binding]; other site
563174002012	Mg2+ binding site [ion binding]; other site
563174002013	G-X-G motif; other site
563174002014	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
563174002015	flagellar motor switch protein; Validated; Region: PRK06788
563174002016	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
563174002017	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911
563174002018	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
563174002019	Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749
563174002020	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
563174002021	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
563174002022	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
563174002023	flagellar motor switch protein; Validated; Region: PRK06789
563174002024	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
563174002025	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
563174002026	flagellar motor switch protein; Reviewed; Region: PRK06782
563174002027	CheC-like family; Region: CheC; pfam04509
563174002028	CheC-like family; Region: CheC; pfam04509
563174002029	Chemotaxis phosphatase CheX; Region: CheX; cl15816
563174002030	CheC-like family; Region: CheC; pfam04509
563174002031	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
563174002032	Protein of unknown function (DUF327); Region: DUF327; pfam03885
563174002033	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799
563174002034	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
563174002035	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073
563174002036	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
563174002037	flagellar capping protein; Validated; Region: fliD; PRK06798
563174002038	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
563174002039	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
563174002040	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
563174002041	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797
563174002042	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558
563174002043	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
563174002044	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699
563174002045	Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766
563174002046	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
563174002047	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
563174002048	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
563174002049	FliG C-terminal domain; Region: FliG_C; pfam01706
563174002050	flagellar assembly protein H; Validated; Region: fliH; PRK06800
563174002051	Flagellar assembly protein FliH; Region: FliH; pfam02108
563174002052	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793
563174002053	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
563174002054	Walker A motif; other site
563174002055	ATP binding site [chemical binding]; other site
563174002056	Walker B motif; other site
563174002057	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
563174002058	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
563174002059	N-acetyl-D-glucosamine binding site [chemical binding]; other site
563174002060	catalytic residue [active]
563174002061	Predicted transcriptional regulators [Transcription]; Region: COG1695
563174002062	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
563174002063	Protein of unknown function (DUF1048); Region: DUF1048; cl01986
563174002064	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
563174002065	pyruvate oxidase; Provisional; Region: PRK08611
563174002066	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
563174002067	PYR/PP interface [polypeptide binding]; other site
563174002068	dimer interface [polypeptide binding]; other site
563174002069	tetramer interface [polypeptide binding]; other site
563174002070	TPP binding site [chemical binding]; other site
563174002071	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
563174002072	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
563174002073	TPP-binding site [chemical binding]; other site
563174002074	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
563174002075	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
563174002076	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
563174002077	dimerization interface [polypeptide binding]; other site
563174002078	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
563174002079	dimer interface [polypeptide binding]; other site
563174002080	putative CheW interface [polypeptide binding]; other site
563174002081	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
563174002082	putative active site [active]
563174002083	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
563174002084	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
563174002085	glutaminase active site [active]
563174002086	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
563174002087	dimer interface [polypeptide binding]; other site
563174002088	active site
563174002089	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
563174002090	dimer interface [polypeptide binding]; other site
563174002091	active site
563174002092	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
563174002093	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
563174002094	active site
563174002095	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
563174002096	GIY-YIG motif/motif A; other site
563174002097	Leucine rich repeat; Region: LRR_8; pfam13855
563174002098	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174002099	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174002100	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174002101	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
563174002102	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174002103	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174002104	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
563174002105	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
563174002106	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174002107	non-specific DNA binding site [nucleotide binding]; other site
563174002108	salt bridge; other site
563174002109	sequence-specific DNA binding site [nucleotide binding]; other site
563174002110	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174002111	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
563174002112	ligand binding site [chemical binding]; other site
563174002113	flexible hinge region; other site
563174002114	Predicted transcriptional regulators [Transcription]; Region: COG1725
563174002115	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174002116	DNA-binding site [nucleotide binding]; DNA binding site
563174002117	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
563174002118	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174002119	Walker A/P-loop; other site
563174002120	ATP binding site [chemical binding]; other site
563174002121	Q-loop/lid; other site
563174002122	ABC transporter signature motif; other site
563174002123	Walker B; other site
563174002124	D-loop; other site
563174002125	H-loop/switch region; other site
563174002126	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
563174002127	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
563174002128	Walker A/P-loop; other site
563174002129	ATP binding site [chemical binding]; other site
563174002130	Q-loop/lid; other site
563174002131	ABC transporter signature motif; other site
563174002132	Walker B; other site
563174002133	D-loop; other site
563174002134	H-loop/switch region; other site
563174002135	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
563174002136	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
563174002137	FtsX-like permease family; Region: FtsX; pfam02687
563174002138	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
563174002139	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174002140	non-specific DNA binding site [nucleotide binding]; other site
563174002141	salt bridge; other site
563174002142	sequence-specific DNA binding site [nucleotide binding]; other site
563174002143	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
563174002144	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174002145	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
563174002146	ligand binding site [chemical binding]; other site
563174002147	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
563174002148	non-specific DNA interactions [nucleotide binding]; other site
563174002149	DNA binding site [nucleotide binding]
563174002150	sequence specific DNA binding site [nucleotide binding]; other site
563174002151	putative cAMP binding site [chemical binding]; other site
563174002152	SnoaL-like domain; Region: SnoaL_4; pfam13577
563174002153	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
563174002154	active site
563174002155	catalytic triad [active]
563174002156	oxyanion hole [active]
563174002157	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174002158	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
563174002159	Walker A/P-loop; other site
563174002160	ATP binding site [chemical binding]; other site
563174002161	Q-loop/lid; other site
563174002162	ABC transporter signature motif; other site
563174002163	Walker B; other site
563174002164	D-loop; other site
563174002165	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
563174002166	H-loop/switch region; other site
563174002167	active site
563174002168	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
563174002169	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
563174002170	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
563174002171	Zn binding site [ion binding]; other site
563174002172	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
563174002173	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
563174002174	Zn binding site [ion binding]; other site
563174002175	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
563174002176	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
563174002177	Zn binding site [ion binding]; other site
563174002178	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
563174002179	Zn binding site [ion binding]; other site
563174002180	Predicted esterase [General function prediction only]; Region: COG0400
563174002181	putative hydrolase; Provisional; Region: PRK11460
563174002182	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
563174002183	GTPases [General function prediction only]; Region: HflX; COG2262
563174002184	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
563174002185	HflX GTPase family; Region: HflX; cd01878
563174002186	G1 box; other site
563174002187	GTP/Mg2+ binding site [chemical binding]; other site
563174002188	Switch I region; other site
563174002189	G2 box; other site
563174002190	G3 box; other site
563174002191	Switch II region; other site
563174002192	G4 box; other site
563174002193	G5 box; other site
563174002194	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
563174002195	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
563174002196	putative active site [active]
563174002197	putative metal binding site [ion binding]; other site
563174002198	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
563174002199	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
563174002200	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
563174002201	Transcriptional regulators [Transcription]; Region: GntR; COG1802
563174002202	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174002203	DNA-binding site [nucleotide binding]; DNA binding site
563174002204	Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289
563174002205	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
563174002206	putative NADP binding site [chemical binding]; other site
563174002207	putative dimer interface [polypeptide binding]; other site
563174002208	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
563174002209	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
563174002210	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
563174002211	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
563174002212	nucleotide binding site [chemical binding]; other site
563174002213	Predicted membrane protein [Function unknown]; Region: COG4811
563174002214	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
563174002215	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
563174002216	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
563174002217	active site
563174002218	phosphorylation site [posttranslational modification]
563174002219	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
563174002220	active pocket/dimerization site; other site
563174002221	active site
563174002222	phosphorylation site [posttranslational modification]
563174002223	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
563174002224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174002225	Walker A motif; other site
563174002226	ATP binding site [chemical binding]; other site
563174002227	Walker B motif; other site
563174002228	arginine finger; other site
563174002229	Transcriptional antiterminator [Transcription]; Region: COG3933
563174002230	PRD domain; Region: PRD; pfam00874
563174002231	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
563174002232	active pocket/dimerization site; other site
563174002233	active site
563174002234	phosphorylation site [posttranslational modification]
563174002235	PRD domain; Region: PRD; pfam00874
563174002236	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
563174002237	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
563174002238	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
563174002239	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
563174002240	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
563174002241	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
563174002242	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
563174002243	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
563174002244	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
563174002245	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
563174002246	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
563174002247	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
563174002248	putative deacylase active site [active]
563174002249	Predicted amidohydrolase [General function prediction only]; Region: COG0388
563174002250	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
563174002251	active site
563174002252	catalytic triad [active]
563174002253	dimer interface [polypeptide binding]; other site
563174002254	Protein of unknown function (DUF554); Region: DUF554; pfam04474
563174002255	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
563174002256	NADH(P)-binding; Region: NAD_binding_10; pfam13460
563174002257	NAD binding site [chemical binding]; other site
563174002258	substrate binding site [chemical binding]; other site
563174002259	putative active site [active]
563174002260	Predicted permeases [General function prediction only]; Region: RarD; COG2962
563174002261	EamA-like transporter family; Region: EamA; pfam00892
563174002262	Uncharacterized conserved protein [Function unknown]; Region: COG2353
563174002263	Transcriptional regulators [Transcription]; Region: MarR; COG1846
563174002264	MarR family; Region: MarR_2; pfam12802
563174002265	lysine transporter; Provisional; Region: PRK10836
563174002266	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
563174002267	PAS domain; Region: PAS_9; pfam13426
563174002268	putative active site [active]
563174002269	heme pocket [chemical binding]; other site
563174002270	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
563174002271	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
563174002272	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
563174002273	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
563174002274	synthetase active site [active]
563174002275	NTP binding site [chemical binding]; other site
563174002276	metal binding site [ion binding]; metal-binding site
563174002277	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
563174002278	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
563174002279	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
563174002280	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174002281	non-specific DNA binding site [nucleotide binding]; other site
563174002282	salt bridge; other site
563174002283	sequence-specific DNA binding site [nucleotide binding]; other site
563174002284	Cupin domain; Region: Cupin_2; pfam07883
563174002285	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
563174002286	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
563174002287	Walker A/P-loop; other site
563174002288	ATP binding site [chemical binding]; other site
563174002289	Q-loop/lid; other site
563174002290	ABC transporter signature motif; other site
563174002291	Walker B; other site
563174002292	D-loop; other site
563174002293	H-loop/switch region; other site
563174002294	TOBE domain; Region: TOBE_2; pfam08402
563174002295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
563174002296	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174002297	putative PBP binding loops; other site
563174002298	ABC-ATPase subunit interface; other site
563174002299	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
563174002300	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174002301	dimer interface [polypeptide binding]; other site
563174002302	conserved gate region; other site
563174002303	putative PBP binding loops; other site
563174002304	ABC-ATPase subunit interface; other site
563174002305	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
563174002306	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
563174002307	Mga helix-turn-helix domain; Region: Mga; pfam05043
563174002308	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
563174002309	Resolvase, N terminal domain; Region: Resolvase; pfam00239
563174002310	Helix-turn-helix domain; Region: HTH_28; pfam13518
563174002311	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
563174002312	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
563174002313	catalytic residues [active]
563174002314	catalytic nucleophile [active]
563174002315	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
563174002316	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
563174002317	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
563174002318	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
563174002319	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
563174002320	classical (c) SDRs; Region: SDR_c; cd05233
563174002321	NAD(P) binding site [chemical binding]; other site
563174002322	active site
563174002323	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
563174002324	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
563174002325	DNA binding residues [nucleotide binding]
563174002326	putative dimer interface [polypeptide binding]; other site
563174002327	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
563174002328	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
563174002329	active site
563174002330	zinc binding site [ion binding]; other site
563174002331	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
563174002332	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
563174002333	Zn2+ binding site [ion binding]; other site
563174002334	Mg2+ binding site [ion binding]; other site
563174002335	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
563174002336	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
563174002337	nucleotide binding site [chemical binding]; other site
563174002338	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
563174002339	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
563174002340	FMN binding site [chemical binding]; other site
563174002341	substrate binding site [chemical binding]; other site
563174002342	putative catalytic residue [active]
563174002343	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
563174002344	dimer interface [polypeptide binding]; other site
563174002345	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
563174002346	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
563174002347	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
563174002348	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
563174002349	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
563174002350	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174002351	motif II; other site
563174002352	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
563174002353	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
563174002354	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174002355	Coenzyme A binding pocket [chemical binding]; other site
563174002356	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
563174002357	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
563174002358	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
563174002359	DNA binding residues [nucleotide binding]
563174002360	putative dimer interface [polypeptide binding]; other site
563174002361	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
563174002362	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
563174002363	active site
563174002364	catalytic tetrad [active]
563174002365	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
563174002366	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
563174002367	homodimer interface [polypeptide binding]; other site
563174002368	catalytic residues [active]
563174002369	NAD binding site [chemical binding]; other site
563174002370	substrate binding pocket [chemical binding]; other site
563174002371	flexible flap; other site
563174002372	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
563174002373	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
563174002374	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
563174002375	PhoU domain; Region: PhoU; pfam01895
563174002376	PhoU domain; Region: PhoU; pfam01895
563174002377	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
563174002378	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
563174002379	dimer interface [polypeptide binding]; other site
563174002380	PYR/PP interface [polypeptide binding]; other site
563174002381	TPP binding site [chemical binding]; other site
563174002382	substrate binding site [chemical binding]; other site
563174002383	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
563174002384	Domain of unknown function; Region: EKR; smart00890
563174002385	4Fe-4S binding domain; Region: Fer4_6; pfam12837
563174002386	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
563174002387	TPP-binding site [chemical binding]; other site
563174002388	dimer interface [polypeptide binding]; other site
563174002389	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
563174002390	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
563174002391	Predicted permeases [General function prediction only]; Region: COG0679
563174002392	Transposase; Region: HTH_Tnp_1; pfam01527
563174002393	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174002394	non-specific DNA binding site [nucleotide binding]; other site
563174002395	salt bridge; other site
563174002396	sequence-specific DNA binding site [nucleotide binding]; other site
563174002397	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
563174002398	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174002399	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174002400	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174002401	Predicted membrane protein [Function unknown]; Region: COG3223
563174002402	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
563174002403	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
563174002404	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
563174002405	Walker A/P-loop; other site
563174002406	ATP binding site [chemical binding]; other site
563174002407	Q-loop/lid; other site
563174002408	ABC transporter signature motif; other site
563174002409	Walker B; other site
563174002410	D-loop; other site
563174002411	H-loop/switch region; other site
563174002412	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
563174002413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174002414	putative substrate translocation pore; other site
563174002415	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174002416	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174002417	Major Facilitator Superfamily; Region: MFS_1; pfam07690
563174002418	putative substrate translocation pore; other site
563174002419	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
563174002420	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
563174002421	putative DNA binding site [nucleotide binding]; other site
563174002422	putative Zn2+ binding site [ion binding]; other site
563174002423	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
563174002424	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
563174002425	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
563174002426	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
563174002427	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174002428	motif II; other site
563174002429	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
563174002430	Predicted membrane protein [Function unknown]; Region: COG3326
563174002431	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
563174002432	homotrimer interaction site [polypeptide binding]; other site
563174002433	putative active site [active]
563174002434	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
563174002435	substrate binding site [chemical binding]; other site
563174002436	zinc-binding site [ion binding]; other site
563174002437	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
563174002438	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
563174002439	GIY-YIG motif/motif A; other site
563174002440	active site
563174002441	catalytic site [active]
563174002442	putative DNA binding site [nucleotide binding]; other site
563174002443	metal binding site [ion binding]; metal-binding site
563174002444	UvrB/uvrC motif; Region: UVR; pfam02151
563174002445	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
563174002446	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
563174002447	substrate binding pocket [chemical binding]; other site
563174002448	membrane-bound complex binding site; other site
563174002449	hinge residues; other site
563174002450	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
563174002451	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174002452	dimer interface [polypeptide binding]; other site
563174002453	conserved gate region; other site
563174002454	putative PBP binding loops; other site
563174002455	ABC-ATPase subunit interface; other site
563174002456	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
563174002457	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
563174002458	Walker A/P-loop; other site
563174002459	ATP binding site [chemical binding]; other site
563174002460	Q-loop/lid; other site
563174002461	ABC transporter signature motif; other site
563174002462	Walker B; other site
563174002463	D-loop; other site
563174002464	H-loop/switch region; other site
563174002465	amidase; Provisional; Region: PRK11910
563174002466	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
563174002467	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
563174002468	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
563174002469	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
563174002470	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
563174002471	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
563174002472	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
563174002473	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
563174002474	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
563174002475	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
563174002476	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
563174002477	Esterase/lipase [General function prediction only]; Region: COG1647
563174002478	Transcriptional regulators [Transcription]; Region: PurR; COG1609
563174002479	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
563174002480	DNA binding site [nucleotide binding]
563174002481	domain linker motif; other site
563174002482	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277
563174002483	putative dimerization interface [polypeptide binding]; other site
563174002484	putative ligand binding site [chemical binding]; other site
563174002485	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
563174002486	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
563174002487	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
563174002488	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174002489	dimer interface [polypeptide binding]; other site
563174002490	conserved gate region; other site
563174002491	putative PBP binding loops; other site
563174002492	ABC-ATPase subunit interface; other site
563174002493	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
563174002494	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174002495	dimer interface [polypeptide binding]; other site
563174002496	conserved gate region; other site
563174002497	ABC-ATPase subunit interface; other site
563174002498	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
563174002499	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
563174002500	Ca binding site [ion binding]; other site
563174002501	active site
563174002502	catalytic site [active]
563174002503	Protein of unknown function (DUF1861); Region: DUF1861; pfam08950
563174002504	Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152
563174002505	active site
563174002506	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
563174002507	active site
563174002508	substrate binding site [chemical binding]; other site
563174002509	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
563174002510	metal binding site [ion binding]; metal-binding site
563174002511	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
563174002512	DEAD-like helicases superfamily; Region: DEXDc; smart00487
563174002513	ATP binding site [chemical binding]; other site
563174002514	Mg++ binding site [ion binding]; other site
563174002515	motif III; other site
563174002516	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
563174002517	nucleotide binding region [chemical binding]; other site
563174002518	ATP-binding site [chemical binding]; other site
563174002519	Predicted membrane protein [Function unknown]; Region: COG4708
563174002520	Domain of unknown function (DUF4176); Region: DUF4176; cl01867
563174002521	The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424
563174002522	F0F1-type ATP synthase, alpha subunit [Energy production and conversion]; Region: AtpA; COG0056
563174002523	Predicted transcriptional regulators [Transcription]; Region: COG1733
563174002524	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
563174002525	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
563174002526	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174002527	putative substrate translocation pore; other site
563174002528	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
563174002529	PRD domain; Region: PRD; pfam00874
563174002530	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
563174002531	active site
563174002532	P-loop; other site
563174002533	phosphorylation site [posttranslational modification]
563174002534	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174002535	active site
563174002536	phosphorylation site [posttranslational modification]
563174002537	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
563174002538	methionine cluster; other site
563174002539	active site
563174002540	phosphorylation site [posttranslational modification]
563174002541	metal binding site [ion binding]; metal-binding site
563174002542	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
563174002543	active site
563174002544	P-loop; other site
563174002545	phosphorylation site [posttranslational modification]
563174002546	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
563174002547	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
563174002548	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
563174002549	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
563174002550	active site
563174002551	trimer interface [polypeptide binding]; other site
563174002552	allosteric site; other site
563174002553	active site lid [active]
563174002554	hexamer (dimer of trimers) interface [polypeptide binding]; other site
563174002555	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
563174002556	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
563174002557	active site
563174002558	catalytic tetrad [active]
563174002559	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
563174002560	Collagen binding domain; Region: Collagen_bind; pfam05737
563174002561	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
563174002562	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
563174002563	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
563174002564	Uncharacterized conserved protein [Function unknown]; Region: COG3402
563174002565	Predicted membrane protein [Function unknown]; Region: COG3428
563174002566	Bacterial PH domain; Region: DUF304; pfam03703
563174002567	Bacterial PH domain; Region: DUF304; pfam03703
563174002568	Bacterial PH domain; Region: DUF304; pfam03703
563174002569	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
563174002570	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
563174002571	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
563174002572	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
563174002573	active site
563174002574	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
563174002575	dimer interface [polypeptide binding]; other site
563174002576	substrate binding site [chemical binding]; other site
563174002577	catalytic residues [active]
563174002578	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
563174002579	PemK-like protein; Region: PemK; pfam02452
563174002580	Rsbr N terminal; Region: Rsbr_N; pfam08678
563174002581	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
563174002582	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
563174002583	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
563174002584	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
563174002585	ATP binding site [chemical binding]; other site
563174002586	Mg2+ binding site [ion binding]; other site
563174002587	G-X-G motif; other site
563174002588	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
563174002589	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
563174002590	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
563174002591	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
563174002592	anti sigma factor interaction site; other site
563174002593	regulatory phosphorylation site [posttranslational modification]; other site
563174002594	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
563174002595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174002596	ATP binding site [chemical binding]; other site
563174002597	Mg2+ binding site [ion binding]; other site
563174002598	G-X-G motif; other site
563174002599	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
563174002600	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
563174002601	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
563174002602	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
563174002603	DNA binding residues [nucleotide binding]
563174002604	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
563174002605	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
563174002606	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
563174002607	Sulfate transporter family; Region: Sulfate_transp; pfam00916
563174002608	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
563174002609	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
563174002610	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
563174002611	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
563174002612	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
563174002613	RNA binding site [nucleotide binding]; other site
563174002614	hypothetical protein; Provisional; Region: PRK04351
563174002615	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
563174002616	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
563174002617	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
563174002618	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
563174002619	Uncharacterized conserved protein [Function unknown]; Region: COG5646
563174002620	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
563174002621	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
563174002622	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
563174002623	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174002624	DNA-binding site [nucleotide binding]; DNA binding site
563174002625	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
563174002626	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
563174002627	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
563174002628	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
563174002629	glutathione reductase; Validated; Region: PRK06116
563174002630	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
563174002631	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
563174002632	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
563174002633	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
563174002634	catalytic core [active]
563174002635	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
563174002636	Domain of unknown function DUF20; Region: UPF0118; pfam01594
563174002637	Predicted transcriptional regulators [Transcription]; Region: COG1725
563174002638	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174002639	DNA-binding site [nucleotide binding]; DNA binding site
563174002640	Predicted membrane protein [General function prediction only]; Region: COG4194
563174002641	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
563174002642	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
563174002643	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
563174002644	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
563174002645	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
563174002646	tetramerization interface [polypeptide binding]; other site
563174002647	NAD(P) binding site [chemical binding]; other site
563174002648	catalytic residues [active]
563174002649	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
563174002650	active site
563174002651	P-loop; other site
563174002652	phosphorylation site [posttranslational modification]
563174002653	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
563174002654	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
563174002655	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
563174002656	methionine cluster; other site
563174002657	active site
563174002658	phosphorylation site [posttranslational modification]
563174002659	metal binding site [ion binding]; metal-binding site
563174002660	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
563174002661	beta-galactosidase; Region: BGL; TIGR03356
563174002662	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
563174002663	Mga helix-turn-helix domain; Region: Mga; pfam05043
563174002664	PRD domain; Region: PRD; pfam00874
563174002665	PRD domain; Region: PRD; pfam00874
563174002666	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174002667	active site
563174002668	phosphorylation site [posttranslational modification]
563174002669	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
563174002670	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
563174002671	ABC transporter; Region: ABC_tran_2; pfam12848
563174002672	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
563174002673	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
563174002674	Predicted permeases [General function prediction only]; Region: COG0701
563174002675	Predicted membrane protein [Function unknown]; Region: COG3689
563174002676	pantothenate kinase; Provisional; Region: PRK05439
563174002677	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
563174002678	ATP-binding site [chemical binding]; other site
563174002679	CoA-binding site [chemical binding]; other site
563174002680	Mg2+-binding site [ion binding]; other site
563174002681	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
563174002682	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
563174002683	Walker A/P-loop; other site
563174002684	ATP binding site [chemical binding]; other site
563174002685	Q-loop/lid; other site
563174002686	ABC transporter signature motif; other site
563174002687	Walker B; other site
563174002688	D-loop; other site
563174002689	H-loop/switch region; other site
563174002690	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
563174002691	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
563174002692	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
563174002693	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
563174002694	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
563174002695	Domain of unknown function (DUF373); Region: DUF373; cl12079
563174002696	Sulfatase; Region: Sulfatase; pfam00884
563174002697	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
563174002698	active site
563174002699	DNA binding site [nucleotide binding]
563174002700	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
563174002701	active site
563174002702	catalytic site [active]
563174002703	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
563174002704	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
563174002705	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
563174002706	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
563174002707	Uncharacterized conserved protein [Function unknown]; Region: COG0398
563174002708	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
563174002709	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
563174002710	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
563174002711	epoxyqueuosine reductase; Region: TIGR00276
563174002712	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
563174002713	A new structural DNA glycosylase; Region: AlkD_like; cl11434
563174002714	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
563174002715	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
563174002716	dimer interface [polypeptide binding]; other site
563174002717	FMN binding site [chemical binding]; other site
563174002718	NADPH bind site [chemical binding]; other site
563174002719	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
563174002720	Low molecular weight phosphatase family; Region: LMWPc; cd00115
563174002721	active site
563174002722	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
563174002723	HSP90 family protein; Provisional; Region: PRK14083
563174002724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174002725	ATP binding site [chemical binding]; other site
563174002726	Mg2+ binding site [ion binding]; other site
563174002727	G-X-G motif; other site
563174002728	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
563174002729	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
563174002730	dimerization interface [polypeptide binding]; other site
563174002731	DPS ferroxidase diiron center [ion binding]; other site
563174002732	ion pore; other site
563174002733	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
563174002734	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
563174002735	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
563174002736	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
563174002737	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
563174002738	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
563174002739	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
563174002740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174002741	putative substrate translocation pore; other site
563174002742	Transcriptional regulators [Transcription]; Region: FadR; COG2186
563174002743	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174002744	DNA-binding site [nucleotide binding]; DNA binding site
563174002745	FCD domain; Region: FCD; pfam07729
563174002746	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
563174002747	Domain of unknown function DUF20; Region: UPF0118; pfam01594
563174002748	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
563174002749	PGAP1-like protein; Region: PGAP1; pfam07819
563174002750	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
563174002751	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
563174002752	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
563174002753	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
563174002754	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
563174002755	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
563174002756	active site
563174002757	dimer interface [polypeptide binding]; other site
563174002758	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
563174002759	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
563174002760	active site
563174002761	trimer interface [polypeptide binding]; other site
563174002762	allosteric site; other site
563174002763	active site lid [active]
563174002764	hexamer (dimer of trimers) interface [polypeptide binding]; other site
563174002765	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
563174002766	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174002767	DNA-binding site [nucleotide binding]; DNA binding site
563174002768	UTRA domain; Region: UTRA; pfam07702
563174002769	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
563174002770	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
563174002771	Mg++ binding site [ion binding]; other site
563174002772	putative catalytic motif [active]
563174002773	substrate binding site [chemical binding]; other site
563174002774	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
563174002775	Peptidase family U32; Region: Peptidase_U32; pfam01136
563174002776	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
563174002777	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
563174002778	Peptidase family U32; Region: Peptidase_U32; pfam01136
563174002779	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
563174002780	heat shock protein HtpX; Provisional; Region: PRK04897
563174002781	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
563174002782	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
563174002783	catalytic residues [active]
563174002784	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
563174002785	putative active site [active]
563174002786	putative metal binding residues [ion binding]; other site
563174002787	signature motif; other site
563174002788	putative triphosphate binding site [ion binding]; other site
563174002789	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
563174002790	TPR motif; other site
563174002791	binding surface
563174002792	Tetratricopeptide repeat; Region: TPR_16; pfam13432
563174002793	Tetratrico peptide repeat; Region: TPR_5; pfam12688
563174002794	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
563174002795	synthetase active site [active]
563174002796	NTP binding site [chemical binding]; other site
563174002797	metal binding site [ion binding]; metal-binding site
563174002798	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
563174002799	ATP-NAD kinase; Region: NAD_kinase; pfam01513
563174002800	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
563174002801	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
563174002802	active site
563174002803	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
563174002804	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
563174002805	NAD binding site [chemical binding]; other site
563174002806	homotetramer interface [polypeptide binding]; other site
563174002807	homodimer interface [polypeptide binding]; other site
563174002808	substrate binding site [chemical binding]; other site
563174002809	active site
563174002810	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
563174002811	DltD N-terminal region; Region: DltD_N; pfam04915
563174002812	DltD central region; Region: DltD_M; pfam04918
563174002813	DltD C-terminal region; Region: DltD_C; pfam04914
563174002814	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
563174002815	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
563174002816	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
563174002817	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
563174002818	acyl-activating enzyme (AAE) consensus motif; other site
563174002819	AMP binding site [chemical binding]; other site
563174002820	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
563174002821	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
563174002822	tetramer (dimer of dimers) interface [polypeptide binding]; other site
563174002823	active site
563174002824	dimer interface [polypeptide binding]; other site
563174002825	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174002826	Coenzyme A binding pocket [chemical binding]; other site
563174002827	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
563174002828	Putative esterase; Region: Esterase; pfam00756
563174002829	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
563174002830	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
563174002831	homodimer interface [polypeptide binding]; other site
563174002832	substrate-cofactor binding pocket; other site
563174002833	catalytic residue [active]
563174002834	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
563174002835	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174002836	Walker A/P-loop; other site
563174002837	ATP binding site [chemical binding]; other site
563174002838	Q-loop/lid; other site
563174002839	ABC transporter signature motif; other site
563174002840	Walker B; other site
563174002841	D-loop; other site
563174002842	H-loop/switch region; other site
563174002843	ABC-2 type transporter; Region: ABC2_membrane; cl17235
563174002844	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
563174002845	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174002846	Major Facilitator Superfamily; Region: MFS_1; pfam07690
563174002847	putative substrate translocation pore; other site
563174002848	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
563174002849	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
563174002850	putative oligomer interface [polypeptide binding]; other site
563174002851	putative active site [active]
563174002852	metal binding site [ion binding]; metal-binding site
563174002853	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
563174002854	catalytic residues [active]
563174002855	dimer interface [polypeptide binding]; other site
563174002856	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
563174002857	LytTr DNA-binding domain; Region: LytTR; smart00850
563174002858	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
563174002859	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174002860	Walker A/P-loop; other site
563174002861	ATP binding site [chemical binding]; other site
563174002862	Q-loop/lid; other site
563174002863	ABC transporter signature motif; other site
563174002864	Walker B; other site
563174002865	D-loop; other site
563174002866	H-loop/switch region; other site
563174002867	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
563174002868	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
563174002869	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
563174002870	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
563174002871	G1 box; other site
563174002872	putative GEF interaction site [polypeptide binding]; other site
563174002873	GTP/Mg2+ binding site [chemical binding]; other site
563174002874	Switch I region; other site
563174002875	G2 box; other site
563174002876	G3 box; other site
563174002877	Switch II region; other site
563174002878	G4 box; other site
563174002879	G5 box; other site
563174002880	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
563174002881	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
563174002882	MarR family; Region: MarR_2; cl17246
563174002883	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
563174002884	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
563174002885	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
563174002886	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
563174002887	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
563174002888	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
563174002889	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
563174002890	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
563174002891	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
563174002892	DNA binding site [nucleotide binding]
563174002893	active site
563174002894	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174002895	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
563174002896	Walker A motif; other site
563174002897	ATP binding site [chemical binding]; other site
563174002898	Walker B motif; other site
563174002899	arginine finger; other site
563174002900	UvrB/uvrC motif; Region: UVR; pfam02151
563174002901	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174002902	Walker A motif; other site
563174002903	ATP binding site [chemical binding]; other site
563174002904	Walker B motif; other site
563174002905	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
563174002906	CAAX protease self-immunity; Region: Abi; pfam02517
563174002907	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
563174002908	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
563174002909	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
563174002910	nucleotide binding site [chemical binding]; other site
563174002911	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873
563174002912	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
563174002913	dimerization domain swap beta strand [polypeptide binding]; other site
563174002914	regulatory protein interface [polypeptide binding]; other site
563174002915	active site
563174002916	regulatory phosphorylation site [posttranslational modification]; other site
563174002917	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
563174002918	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
563174002919	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
563174002920	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
563174002921	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
563174002922	Uncharacterized conserved protein [Function unknown]; Region: COG1434
563174002923	putative active site [active]
563174002924	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
563174002925	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
563174002926	aminotransferase A; Validated; Region: PRK07683
563174002927	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
563174002928	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174002929	homodimer interface [polypeptide binding]; other site
563174002930	catalytic residue [active]
563174002931	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
563174002932	FOG: CBS domain [General function prediction only]; Region: COG0517
563174002933	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
563174002934	Transcriptional regulator [Transcription]; Region: LysR; COG0583
563174002935	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
563174002936	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
563174002937	dimerization interface [polypeptide binding]; other site
563174002938	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
563174002939	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
563174002940	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
563174002941	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
563174002942	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
563174002943	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
563174002944	metal binding site [ion binding]; metal-binding site
563174002945	putative dimer interface [polypeptide binding]; other site
563174002946	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
563174002947	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
563174002948	Mechanosensitive ion channel; Region: MS_channel; pfam00924
563174002949	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
563174002950	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174002951	Walker A/P-loop; other site
563174002952	ATP binding site [chemical binding]; other site
563174002953	Q-loop/lid; other site
563174002954	ABC transporter signature motif; other site
563174002955	Walker B; other site
563174002956	D-loop; other site
563174002957	H-loop/switch region; other site
563174002958	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
563174002959	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174002960	dimer interface [polypeptide binding]; other site
563174002961	conserved gate region; other site
563174002962	putative PBP binding loops; other site
563174002963	ABC-ATPase subunit interface; other site
563174002964	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
563174002965	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
563174002966	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
563174002967	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
563174002968	HPr interaction site; other site
563174002969	glycerol kinase (GK) interaction site [polypeptide binding]; other site
563174002970	active site
563174002971	phosphorylation site [posttranslational modification]
563174002972	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
563174002973	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
563174002974	S1 domain; Region: S1_2; pfam13509
563174002975	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
563174002976	RNA binding site [nucleotide binding]; other site
563174002977	Predicted membrane protein [Function unknown]; Region: COG4758
563174002978	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
563174002979	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
563174002980	Histidine kinase; Region: HisKA_3; pfam07730
563174002981	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174002982	ATP binding site [chemical binding]; other site
563174002983	Mg2+ binding site [ion binding]; other site
563174002984	G-X-G motif; other site
563174002985	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
563174002986	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174002987	active site
563174002988	phosphorylation site [posttranslational modification]
563174002989	intermolecular recognition site; other site
563174002990	dimerization interface [polypeptide binding]; other site
563174002991	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
563174002992	DNA binding residues [nucleotide binding]
563174002993	dimerization interface [polypeptide binding]; other site
563174002994	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
563174002995	TrkA-N domain; Region: TrkA_N; pfam02254
563174002996	TrkA-C domain; Region: TrkA_C; pfam02080
563174002997	Predicted membrane protein [Function unknown]; Region: COG1289
563174002998	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
563174002999	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
563174003000	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
563174003001	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
563174003002	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
563174003003	hypothetical protein; Provisional; Region: PRK13667
563174003004	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
563174003005	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174003006	active site
563174003007	motif I; other site
563174003008	motif II; other site
563174003009	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174003010	Uncharacterized integral membrane protein [Function unknown]; Region: COG3739
563174003011	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
563174003012	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
563174003013	GTP binding site; other site
563174003014	ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297
563174003015	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
563174003016	Walker A/P-loop; other site
563174003017	ATP binding site [chemical binding]; other site
563174003018	Q-loop/lid; other site
563174003019	ABC transporter signature motif; other site
563174003020	Walker B; other site
563174003021	D-loop; other site
563174003022	H-loop/switch region; other site
563174003023	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174003024	dimer interface [polypeptide binding]; other site
563174003025	conserved gate region; other site
563174003026	putative PBP binding loops; other site
563174003027	ABC-ATPase subunit interface; other site
563174003028	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
563174003029	PBP superfamily domain; Region: PBP_like_2; cl17296
563174003030	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
563174003031	membrane-bound complex binding site; other site
563174003032	hinge residues; other site
563174003033	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
563174003034	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
563174003035	dimer interface [polypeptide binding]; other site
563174003036	putative functional site; other site
563174003037	putative MPT binding site; other site
563174003038	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
563174003039	Walker A motif; other site
563174003040	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
563174003041	MoaE homodimer interface [polypeptide binding]; other site
563174003042	MoaD interaction [polypeptide binding]; other site
563174003043	active site residues [active]
563174003044	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
563174003045	MoaE interaction surface [polypeptide binding]; other site
563174003046	MoeB interaction surface [polypeptide binding]; other site
563174003047	thiocarboxylated glycine; other site
563174003048	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
563174003049	trimer interface [polypeptide binding]; other site
563174003050	dimer interface [polypeptide binding]; other site
563174003051	putative active site [active]
563174003052	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
563174003053	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
563174003054	FeS/SAM binding site; other site
563174003055	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
563174003056	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
563174003057	MPT binding site; other site
563174003058	trimer interface [polypeptide binding]; other site
563174003059	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
563174003060	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
563174003061	ATP binding site [chemical binding]; other site
563174003062	substrate interface [chemical binding]; other site
563174003063	Flavin Reductases; Region: FlaRed; cl00801
563174003064	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
563174003065	active site
563174003066	catalytic residues [active]
563174003067	metal binding site [ion binding]; metal-binding site
563174003068	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
563174003069	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
563174003070	TPP-binding site [chemical binding]; other site
563174003071	tetramer interface [polypeptide binding]; other site
563174003072	heterodimer interface [polypeptide binding]; other site
563174003073	phosphorylation loop region [posttranslational modification]
563174003074	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
563174003075	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
563174003076	alpha subunit interface [polypeptide binding]; other site
563174003077	TPP binding site [chemical binding]; other site
563174003078	heterodimer interface [polypeptide binding]; other site
563174003079	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
563174003080	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
563174003081	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
563174003082	E3 interaction surface; other site
563174003083	lipoyl attachment site [posttranslational modification]; other site
563174003084	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
563174003085	E3 interaction surface; other site
563174003086	lipoyl attachment site [posttranslational modification]; other site
563174003087	e3 binding domain; Region: E3_binding; pfam02817
563174003088	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
563174003089	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
563174003090	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
563174003091	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
563174003092	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
563174003093	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
563174003094	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
563174003095	NAD(P) binding site [chemical binding]; other site
563174003096	LDH/MDH dimer interface [polypeptide binding]; other site
563174003097	substrate binding site [chemical binding]; other site
563174003098	Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256
563174003099	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
563174003100	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
563174003101	catalytic residues [active]
563174003102	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
563174003103	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
563174003104	Cl binding site [ion binding]; other site
563174003105	oligomer interface [polypeptide binding]; other site
563174003106	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
563174003107	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
563174003108	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
563174003109	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
563174003110	active site
563174003111	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
563174003112	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
563174003113	G1 box; other site
563174003114	putative GEF interaction site [polypeptide binding]; other site
563174003115	GTP/Mg2+ binding site [chemical binding]; other site
563174003116	Switch I region; other site
563174003117	G2 box; other site
563174003118	G3 box; other site
563174003119	Switch II region; other site
563174003120	G4 box; other site
563174003121	G5 box; other site
563174003122	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
563174003123	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
563174003124	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896
563174003125	hypothetical protein; Provisional; Region: PRK13666
563174003126	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
563174003127	pyruvate carboxylase; Reviewed; Region: PRK12999
563174003128	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
563174003129	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
563174003130	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
563174003131	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
563174003132	active site
563174003133	catalytic residues [active]
563174003134	metal binding site [ion binding]; metal-binding site
563174003135	homodimer binding site [polypeptide binding]; other site
563174003136	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
563174003137	carboxyltransferase (CT) interaction site; other site
563174003138	biotinylation site [posttranslational modification]; other site
563174003139	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
563174003140	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
563174003141	putative binding site residues; other site
563174003142	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
563174003143	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
563174003144	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
563174003145	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
563174003146	Walker A/P-loop; other site
563174003147	ATP binding site [chemical binding]; other site
563174003148	Q-loop/lid; other site
563174003149	ABC transporter signature motif; other site
563174003150	Walker B; other site
563174003151	D-loop; other site
563174003152	H-loop/switch region; other site
563174003153	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
563174003154	SH3-like domain; Region: SH3_8; pfam13457
563174003155	SH3-like domain; Region: SH3_8; pfam13457
563174003156	SH3-like domain; Region: SH3_8; pfam13457
563174003157	SH3-like domain; Region: SH3_8; pfam13457
563174003158	SH3-like domain; Region: SH3_8; pfam13457
563174003159	SH3-like domain; Region: SH3_8; pfam13457
563174003160	SH3-like domain; Region: SH3_8; pfam13457
563174003161	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
563174003162	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
563174003163	Ligand binding site; other site
563174003164	Putative Catalytic site; other site
563174003165	DXD motif; other site
563174003166	conserved hypothetical integral membrane protein; Region: TIGR03766
563174003167	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
563174003168	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
563174003169	active site
563174003170	tetramer interface; other site
563174003171	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
563174003172	active site
563174003173	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
563174003174	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
563174003175	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
563174003176	substrate binding site; other site
563174003177	dimer interface; other site
563174003178	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
563174003179	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
563174003180	putative NAD(P) binding site [chemical binding]; other site
563174003181	putative catalytic Zn binding site [ion binding]; other site
563174003182	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
563174003183	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
563174003184	active site
563174003185	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
563174003186	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
563174003187	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
563174003188	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
563174003189	glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171
563174003190	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
563174003191	active site
563174003192	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
563174003193	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
563174003194	active site
563174003195	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
563174003196	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
563174003197	homodimer interface [polypeptide binding]; other site
563174003198	NAD binding pocket [chemical binding]; other site
563174003199	ATP binding pocket [chemical binding]; other site
563174003200	Mg binding site [ion binding]; other site
563174003201	active-site loop [active]
563174003202	Uncharacterized conserved protein [Function unknown]; Region: COG1359
563174003203	Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440
563174003204	active site
563174003205	P-loop; other site
563174003206	phosphorylation site [posttranslational modification]
563174003207	GMP synthase; Reviewed; Region: guaA; PRK00074
563174003208	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
563174003209	AMP/PPi binding site [chemical binding]; other site
563174003210	candidate oxyanion hole; other site
563174003211	catalytic triad [active]
563174003212	potential glutamine specificity residues [chemical binding]; other site
563174003213	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
563174003214	ATP Binding subdomain [chemical binding]; other site
563174003215	Dimerization subdomain; other site
563174003216	Domain of unknown function (DUF4274); Region: DUF4274; pfam14096
563174003217	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
563174003218	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174003219	Coenzyme A binding pocket [chemical binding]; other site
563174003220	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
563174003221	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
563174003222	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
563174003223	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174003224	Coenzyme A binding pocket [chemical binding]; other site
563174003225	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
563174003226	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
563174003227	DNA binding residues [nucleotide binding]
563174003228	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
563174003229	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
563174003230	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174003231	Walker A/P-loop; other site
563174003232	ATP binding site [chemical binding]; other site
563174003233	Q-loop/lid; other site
563174003234	ABC transporter signature motif; other site
563174003235	Walker B; other site
563174003236	D-loop; other site
563174003237	H-loop/switch region; other site
563174003238	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
563174003239	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174003240	Walker A/P-loop; other site
563174003241	ATP binding site [chemical binding]; other site
563174003242	Q-loop/lid; other site
563174003243	ABC transporter signature motif; other site
563174003244	Walker B; other site
563174003245	D-loop; other site
563174003246	H-loop/switch region; other site
563174003247	Uncharacterized conserved protein [Function unknown]; Region: COG1359
563174003248	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
563174003249	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
563174003250	DNA binding residues [nucleotide binding]
563174003251	putative dimer interface [polypeptide binding]; other site
563174003252	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
563174003253	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
563174003254	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
563174003255	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
563174003256	LRR adjacent; Region: LRR_adjacent; pfam08191
563174003257	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
563174003258	Clp protease; Region: CLP_protease; pfam00574
563174003259	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
563174003260	oligomer interface [polypeptide binding]; other site
563174003261	active site residues [active]
563174003262	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
563174003263	dimer interface [polypeptide binding]; other site
563174003264	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
563174003265	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
563174003266	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
563174003267	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
563174003268	SLBB domain; Region: SLBB; pfam10531
563174003269	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
563174003270	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
563174003271	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
563174003272	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
563174003273	putative hexamer interface [polypeptide binding]; other site
563174003274	putative hexagonal pore; other site
563174003275	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
563174003276	putative hexamer interface [polypeptide binding]; other site
563174003277	putative hexagonal pore; other site
563174003278	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
563174003279	putative hexamer interface [polypeptide binding]; other site
563174003280	putative hexagonal pore; other site
563174003281	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
563174003282	G1 box; other site
563174003283	GTP/Mg2+ binding site [chemical binding]; other site
563174003284	G2 box; other site
563174003285	Switch I region; other site
563174003286	G3 box; other site
563174003287	Switch II region; other site
563174003288	G4 box; other site
563174003289	G5 box; other site
563174003290	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
563174003291	homotrimer interface [polypeptide binding]; other site
563174003292	Walker A motif; other site
563174003293	GTP binding site [chemical binding]; other site
563174003294	Walker B motif; other site
563174003295	Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368
563174003296	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
563174003297	catalytic core [active]
563174003298	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
563174003299	Sensory domain found in PocR; Region: PocR; pfam10114
563174003300	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
563174003301	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
563174003302	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
563174003303	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
563174003304	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
563174003305	Hexamer interface [polypeptide binding]; other site
563174003306	Hexagonal pore residue; other site
563174003307	propanediol utilization protein PduB; Provisional; Region: PRK15415
563174003308	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
563174003309	putative hexamer interface [polypeptide binding]; other site
563174003310	putative hexagonal pore; other site
563174003311	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
563174003312	putative hexamer interface [polypeptide binding]; other site
563174003313	putative hexagonal pore; other site
563174003314	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
563174003315	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
563174003316	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
563174003317	alpha-beta subunit interface [polypeptide binding]; other site
563174003318	alpha-gamma subunit interface [polypeptide binding]; other site
563174003319	active site
563174003320	substrate and K+ binding site; other site
563174003321	K+ binding site [ion binding]; other site
563174003322	cobalamin binding site [chemical binding]; other site
563174003323	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
563174003324	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
563174003325	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
563174003326	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
563174003327	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
563174003328	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
563174003329	putative hexamer interface [polypeptide binding]; other site
563174003330	putative hexagonal pore; other site
563174003331	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
563174003332	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
563174003333	Hexamer interface [polypeptide binding]; other site
563174003334	Hexagonal pore residue; other site
563174003335	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
563174003336	Propanediol utilisation protein PduL; Region: PduL; pfam06130
563174003337	Propanediol utilisation protein PduL; Region: PduL; pfam06130
563174003338	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
563174003339	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
563174003340	nucleotide binding site [chemical binding]; other site
563174003341	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
563174003342	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
563174003343	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
563174003344	Hexamer/Pentamer interface [polypeptide binding]; other site
563174003345	central pore; other site
563174003346	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
563174003347	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
563174003348	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
563174003349	putative catalytic cysteine [active]
563174003350	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
563174003351	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
563174003352	putative active site [active]
563174003353	metal binding site [ion binding]; metal-binding site
563174003354	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
563174003355	amphipathic channel; other site
563174003356	Asn-Pro-Ala signature motifs; other site
563174003357	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
563174003358	propionate/acetate kinase; Provisional; Region: PRK12379
563174003359	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
563174003360	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
563174003361	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174003362	homodimer interface [polypeptide binding]; other site
563174003363	catalytic residue [active]
563174003364	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
563174003365	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
563174003366	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
563174003367	putative active site [active]
563174003368	metal binding site [ion binding]; metal-binding site
563174003369	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
563174003370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174003371	active site
563174003372	phosphorylation site [posttranslational modification]
563174003373	intermolecular recognition site; other site
563174003374	dimerization interface [polypeptide binding]; other site
563174003375	ANTAR domain; Region: ANTAR; pfam03861
563174003376	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
563174003377	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
563174003378	Histidine kinase; Region: HisKA_2; pfam07568
563174003379	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174003380	ATP binding site [chemical binding]; other site
563174003381	Mg2+ binding site [ion binding]; other site
563174003382	G-X-G motif; other site
563174003383	Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819
563174003384	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
563174003385	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
563174003386	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
563174003387	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
563174003388	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
563174003389	putative hexamer interface [polypeptide binding]; other site
563174003390	putative hexagonal pore; other site
563174003391	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
563174003392	putative hexamer interface [polypeptide binding]; other site
563174003393	putative hexagonal pore; other site
563174003394	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
563174003395	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
563174003396	Hexamer interface [polypeptide binding]; other site
563174003397	Hexagonal pore residue; other site
563174003398	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
563174003399	putative catalytic cysteine [active]
563174003400	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
563174003401	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
563174003402	Hexamer interface [polypeptide binding]; other site
563174003403	Putative hexagonal pore residue; other site
563174003404	Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812
563174003405	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
563174003406	Propanediol utilisation protein PduL; Region: PduL; pfam06130
563174003407	Propanediol utilisation protein PduL; Region: PduL; pfam06130
563174003408	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
563174003409	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
563174003410	Hexamer/Pentamer interface [polypeptide binding]; other site
563174003411	central pore; other site
563174003412	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
563174003413	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
563174003414	putative hexamer interface [polypeptide binding]; other site
563174003415	putative hexagonal pore; other site
563174003416	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
563174003417	putative hexamer interface [polypeptide binding]; other site
563174003418	putative hexagonal pore; other site
563174003419	Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346
563174003420	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
563174003421	Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249
563174003422	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
563174003423	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
563174003424	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
563174003425	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
563174003426	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
563174003427	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
563174003428	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
563174003429	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
563174003430	catalytic triad [active]
563174003431	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
563174003432	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
563174003433	Precorrin-8X methylmutase; Region: CbiC; pfam02570
563174003434	Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903
563174003435	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
563174003436	active site
563174003437	putative homodimer interface [polypeptide binding]; other site
563174003438	SAM binding site [chemical binding]; other site
563174003439	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
563174003440	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174003441	S-adenosylmethionine binding site [chemical binding]; other site
563174003442	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
563174003443	active site
563174003444	SAM binding site [chemical binding]; other site
563174003445	homodimer interface [polypeptide binding]; other site
563174003446	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
563174003447	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
563174003448	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
563174003449	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
563174003450	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
563174003451	active site
563174003452	SAM binding site [chemical binding]; other site
563174003453	homodimer interface [polypeptide binding]; other site
563174003454	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
563174003455	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
563174003456	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
563174003457	active site
563174003458	SAM binding site [chemical binding]; other site
563174003459	homodimer interface [polypeptide binding]; other site
563174003460	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
563174003461	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
563174003462	active site
563174003463	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
563174003464	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
563174003465	active site
563174003466	C-terminal domain interface [polypeptide binding]; other site
563174003467	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
563174003468	active site
563174003469	N-terminal domain interface [polypeptide binding]; other site
563174003470	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
563174003471	active site
563174003472	SAM binding site [chemical binding]; other site
563174003473	homodimer interface [polypeptide binding]; other site
563174003474	cobalt transport protein CbiM; Validated; Region: PRK08319
563174003475	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
563174003476	ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930
563174003477	cobalt transport protein CbiQ; Provisional; Region: PRK15485
563174003478	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
563174003479	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
563174003480	Walker A/P-loop; other site
563174003481	ATP binding site [chemical binding]; other site
563174003482	Q-loop/lid; other site
563174003483	ABC transporter signature motif; other site
563174003484	Walker B; other site
563174003485	D-loop; other site
563174003486	H-loop/switch region; other site
563174003487	cobyric acid synthase; Provisional; Region: PRK00784
563174003488	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
563174003489	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
563174003490	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
563174003491	catalytic triad [active]
563174003492	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
563174003493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
563174003494	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
563174003495	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
563174003496	AAA domain; Region: AAA_17; pfam13207
563174003497	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
563174003498	SH3-like domain; Region: SH3_8; pfam13457
563174003499	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
563174003500	SH3-like domain; Region: SH3_8; pfam13457
563174003501	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
563174003502	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
563174003503	oligomer interface [polypeptide binding]; other site
563174003504	active site
563174003505	metal binding site [ion binding]; metal-binding site
563174003506	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
563174003507	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
563174003508	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
563174003509	Predicted transcriptional regulators [Transcription]; Region: COG1733
563174003510	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
563174003511	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
563174003512	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
563174003513	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
563174003514	dimer interface [polypeptide binding]; other site
563174003515	motif 1; other site
563174003516	active site
563174003517	motif 2; other site
563174003518	motif 3; other site
563174003519	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
563174003520	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
563174003521	putative tRNA-binding site [nucleotide binding]; other site
563174003522	B3/4 domain; Region: B3_4; pfam03483
563174003523	tRNA synthetase B5 domain; Region: B5; smart00874
563174003524	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
563174003525	dimer interface [polypeptide binding]; other site
563174003526	motif 1; other site
563174003527	motif 3; other site
563174003528	motif 2; other site
563174003529	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
563174003530	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
563174003531	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
563174003532	Walker A/P-loop; other site
563174003533	ATP binding site [chemical binding]; other site
563174003534	Q-loop/lid; other site
563174003535	ABC transporter signature motif; other site
563174003536	Walker B; other site
563174003537	D-loop; other site
563174003538	H-loop/switch region; other site
563174003539	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
563174003540	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
563174003541	FtsX-like permease family; Region: FtsX; pfam02687
563174003542	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
563174003543	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
563174003544	FtsX-like permease family; Region: FtsX; pfam02687
563174003545	Transcriptional regulators [Transcription]; Region: MarR; COG1846
563174003546	MarR family; Region: MarR; pfam01047
563174003547	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
563174003548	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
563174003549	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
563174003550	ligand binding site [chemical binding]; other site
563174003551	active site
563174003552	UGI interface [polypeptide binding]; other site
563174003553	catalytic site [active]
563174003554	ribonuclease HIII; Provisional; Region: PRK00996
563174003555	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
563174003556	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
563174003557	RNA/DNA hybrid binding site [nucleotide binding]; other site
563174003558	active site
563174003559	Cell division protein ZapA; Region: ZapA; cl01146
563174003560	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
563174003561	Colicin V production protein; Region: Colicin_V; pfam02674
563174003562	hypothetical protein; Provisional; Region: PRK08609
563174003563	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
563174003564	active site
563174003565	primer binding site [nucleotide binding]; other site
563174003566	NTP  binding site [chemical binding]; other site
563174003567	metal binding triad [ion binding]; metal-binding site
563174003568	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
563174003569	active site
563174003570	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
563174003571	MutS domain III; Region: MutS_III; pfam05192
563174003572	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174003573	Walker A/P-loop; other site
563174003574	ATP binding site [chemical binding]; other site
563174003575	Q-loop/lid; other site
563174003576	ABC transporter signature motif; other site
563174003577	Walker B; other site
563174003578	D-loop; other site
563174003579	H-loop/switch region; other site
563174003580	Smr domain; Region: Smr; pfam01713
563174003581	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
563174003582	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
563174003583	catalytic residues [active]
563174003584	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
563174003585	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
563174003586	GIY-YIG motif/motif A; other site
563174003587	active site
563174003588	catalytic site [active]
563174003589	putative DNA binding site [nucleotide binding]; other site
563174003590	metal binding site [ion binding]; metal-binding site
563174003591	UvrB/uvrC motif; Region: UVR; pfam02151
563174003592	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
563174003593	aspartate kinase; Reviewed; Region: PRK06635
563174003594	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
563174003595	putative nucleotide binding site [chemical binding]; other site
563174003596	putative catalytic residues [active]
563174003597	putative Mg ion binding site [ion binding]; other site
563174003598	putative aspartate binding site [chemical binding]; other site
563174003599	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
563174003600	putative allosteric regulatory site; other site
563174003601	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
563174003602	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
563174003603	Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796
563174003604	ribonuclease PH; Reviewed; Region: rph; PRK00173
563174003605	Ribonuclease PH; Region: RNase_PH_bact; cd11362
563174003606	hexamer interface [polypeptide binding]; other site
563174003607	active site
563174003608	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
563174003609	active site
563174003610	dimerization interface [polypeptide binding]; other site
563174003611	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
563174003612	active site
563174003613	metal binding site [ion binding]; metal-binding site
563174003614	homotetramer interface [polypeptide binding]; other site
563174003615	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
563174003616	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
563174003617	Int/Topo IB signature motif; other site
563174003618	Domain of unknown function (DUF955); Region: DUF955; pfam06114
563174003619	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
563174003620	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174003621	non-specific DNA binding site [nucleotide binding]; other site
563174003622	salt bridge; other site
563174003623	sequence-specific DNA binding site [nucleotide binding]; other site
563174003624	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174003625	salt bridge; other site
563174003626	non-specific DNA binding site [nucleotide binding]; other site
563174003627	sequence-specific DNA binding site [nucleotide binding]; other site
563174003628	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
563174003629	cofactor binding site; other site
563174003630	DNA binding site [nucleotide binding]
563174003631	substrate interaction site [chemical binding]; other site
563174003632	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
563174003633	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475
563174003634	Zn binding site [ion binding]; other site
563174003635	YopX protein; Region: YopX; cl09859
563174003636	hypothetical protein; Provisional; Region: PRK10220
563174003637	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
563174003638	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
563174003639	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
563174003640	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
563174003641	AAA domain; Region: AAA_24; pfam13479
563174003642	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
563174003643	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
563174003644	ATP binding site [chemical binding]; other site
563174003645	putative Mg++ binding site [ion binding]; other site
563174003646	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
563174003647	nucleotide binding region [chemical binding]; other site
563174003648	ATP-binding site [chemical binding]; other site
563174003649	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
563174003650	Protein of unknown function (DUF669); Region: DUF669; pfam05037
563174003651	Uncharacterized conserved protein [Function unknown]; Region: COG4983
563174003652	Phage associated DNA primase [General function prediction only]; Region: COG3378
563174003653	D5 N terminal like; Region: D5_N; pfam08706
563174003654	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
563174003655	VRR-NUC domain; Region: VRR_NUC; pfam08774
563174003656	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
563174003657	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
563174003658	Protein of unknown function (DUF722); Region: DUF722; pfam05263
563174003659	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
563174003660	putative active site [active]
563174003661	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
563174003662	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
563174003663	Phage portal protein; Region: Phage_portal; pfam04860
563174003664	Phage-related protein [Function unknown]; Region: COG4695; cl01923
563174003665	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
563174003666	oligomer interface [polypeptide binding]; other site
563174003667	active site residues [active]
563174003668	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
563174003669	Phage capsid family; Region: Phage_capsid; pfam05065
563174003670	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
563174003671	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
563174003672	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
563174003673	N-acetyl-D-glucosamine binding site [chemical binding]; other site
563174003674	catalytic residue [active]
563174003675	Phage tail protein; Region: Sipho_tail; pfam05709
563174003676	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
563174003677	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
563174003678	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
563174003679	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
563174003680	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900
563174003681	Bacteriophage holin; Region: Phage_holin_1; pfam04531
563174003682	Bacterial SH3 domain; Region: SH3_3; cl17532
563174003683	Bacterial SH3 domain; Region: SH3_3; cl17532
563174003684	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
563174003685	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
563174003686	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
563174003687	Cna protein B-type domain; Region: Cna_B; pfam05738
563174003688	Cna protein B-type domain; Region: Cna_B; pfam05738
563174003689	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
563174003690	Helix-turn-helix domain; Region: HTH_16; pfam12645
563174003691	SUKH-3 immunity protein; Region: SUKH-3; pfam14433
563174003692	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
563174003693	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
563174003694	LRR adjacent; Region: LRR_adjacent; pfam08191
563174003695	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174003696	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174003697	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174003698	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174003699	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174003700	Uncharacterized conserved protein [Function unknown]; Region: COG5361
563174003701	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
563174003702	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
563174003703	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
563174003704	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
563174003705	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
563174003706	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
563174003707	dimer interface [polypeptide binding]; other site
563174003708	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
563174003709	catalytic core [active]
563174003710	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
563174003711	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
563174003712	ATP binding site [chemical binding]; other site
563174003713	Mg++ binding site [ion binding]; other site
563174003714	motif III; other site
563174003715	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
563174003716	nucleotide binding region [chemical binding]; other site
563174003717	ATP-binding site [chemical binding]; other site
563174003718	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
563174003719	RNA binding site [nucleotide binding]; other site
563174003720	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
563174003721	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
563174003722	putative active site [active]
563174003723	nucleotide binding site [chemical binding]; other site
563174003724	nudix motif; other site
563174003725	putative metal binding site [ion binding]; other site
563174003726	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174003727	Major Facilitator Superfamily; Region: MFS_1; pfam07690
563174003728	putative substrate translocation pore; other site
563174003729	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174003730	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
563174003731	ligand binding site [chemical binding]; other site
563174003732	flexible hinge region; other site
563174003733	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
563174003734	Uncharacterized conserved protein [Function unknown]; Region: COG1284
563174003735	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
563174003736	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
563174003737	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
563174003738	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174003739	DNA-binding site [nucleotide binding]; DNA binding site
563174003740	UTRA domain; Region: UTRA; pfam07702
563174003741	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
563174003742	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
563174003743	Ca binding site [ion binding]; other site
563174003744	active site
563174003745	catalytic site [active]
563174003746	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
563174003747	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
563174003748	active site turn [active]
563174003749	phosphorylation site [posttranslational modification]
563174003750	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
563174003751	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
563174003752	nudix motif; other site
563174003753	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
563174003754	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
563174003755	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
563174003756	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
563174003757	putative catalytic cysteine [active]
563174003758	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
563174003759	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
563174003760	nucleotide binding site [chemical binding]; other site
563174003761	homotetrameric interface [polypeptide binding]; other site
563174003762	putative phosphate binding site [ion binding]; other site
563174003763	putative allosteric binding site; other site
563174003764	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
563174003765	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
563174003766	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
563174003767	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174003768	non-specific DNA binding site [nucleotide binding]; other site
563174003769	salt bridge; other site
563174003770	sequence-specific DNA binding site [nucleotide binding]; other site
563174003771	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174003772	non-specific DNA binding site [nucleotide binding]; other site
563174003773	salt bridge; other site
563174003774	sequence-specific DNA binding site [nucleotide binding]; other site
563174003775	trigger factor; Provisional; Region: tig; PRK01490
563174003776	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
563174003777	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
563174003778	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
563174003779	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
563174003780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174003781	Walker A motif; other site
563174003782	ATP binding site [chemical binding]; other site
563174003783	Walker B motif; other site
563174003784	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
563174003785	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
563174003786	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
563174003787	Catalytic site [active]
563174003788	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
563174003789	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
563174003790	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
563174003791	Catalytic site [active]
563174003792	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
563174003793	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
563174003794	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
563174003795	Catalytic site [active]
563174003796	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
563174003797	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
563174003798	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
563174003799	GTP/Mg2+ binding site [chemical binding]; other site
563174003800	G4 box; other site
563174003801	G5 box; other site
563174003802	G1 box; other site
563174003803	Switch I region; other site
563174003804	G2 box; other site
563174003805	G3 box; other site
563174003806	Switch II region; other site
563174003807	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
563174003808	RNA/DNA hybrid binding site [nucleotide binding]; other site
563174003809	active site
563174003810	DNA protecting protein DprA; Region: dprA; TIGR00732
563174003811	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
563174003812	DNA topoisomerase I; Validated; Region: PRK05582
563174003813	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
563174003814	active site
563174003815	interdomain interaction site; other site
563174003816	putative metal-binding site [ion binding]; other site
563174003817	nucleotide binding site [chemical binding]; other site
563174003818	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
563174003819	domain I; other site
563174003820	DNA binding groove [nucleotide binding]
563174003821	phosphate binding site [ion binding]; other site
563174003822	domain II; other site
563174003823	domain III; other site
563174003824	nucleotide binding site [chemical binding]; other site
563174003825	catalytic site [active]
563174003826	domain IV; other site
563174003827	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
563174003828	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
563174003829	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
563174003830	Glucose inhibited division protein A; Region: GIDA; pfam01134
563174003831	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
563174003832	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
563174003833	active site
563174003834	DNA binding site [nucleotide binding]
563174003835	Int/Topo IB signature motif; other site
563174003836	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
563174003837	active site
563174003838	HslU subunit interaction site [polypeptide binding]; other site
563174003839	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
563174003840	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174003841	Walker A motif; other site
563174003842	ATP binding site [chemical binding]; other site
563174003843	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
563174003844	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
563174003845	transcriptional repressor CodY; Validated; Region: PRK04158
563174003846	CodY GAF-like domain; Region: CodY; pfam06018
563174003847	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
563174003848	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
563174003849	active site
563174003850	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
563174003851	active site
563174003852	catalytic residues [active]
563174003853	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
563174003854	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
563174003855	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
563174003856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174003857	Mg2+ binding site [ion binding]; other site
563174003858	G-X-G motif; other site
563174003859	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
563174003860	anchoring element; other site
563174003861	dimer interface [polypeptide binding]; other site
563174003862	ATP binding site [chemical binding]; other site
563174003863	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
563174003864	active site
563174003865	putative metal-binding site [ion binding]; other site
563174003866	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
563174003867	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
563174003868	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
563174003869	CAP-like domain; other site
563174003870	active site
563174003871	primary dimer interface [polypeptide binding]; other site
563174003872	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
563174003873	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
563174003874	S-ribosylhomocysteinase; Provisional; Region: PRK02260
563174003875	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
563174003876	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
563174003877	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
563174003878	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
563174003879	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
563174003880	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
563174003881	catalytic triad [active]
563174003882	catalytic triad [active]
563174003883	oxyanion hole [active]
563174003884	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
563174003885	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
563174003886	active site
563174003887	catalytic site [active]
563174003888	metal binding site [ion binding]; metal-binding site
563174003889	dimer interface [polypeptide binding]; other site
563174003890	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
563174003891	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
563174003892	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
563174003893	bacterial Hfq-like; Region: Hfq; cd01716
563174003894	hexamer interface [polypeptide binding]; other site
563174003895	Sm1 motif; other site
563174003896	RNA binding site [nucleotide binding]; other site
563174003897	Sm2 motif; other site
563174003898	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
563174003899	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
563174003900	HflX GTPase family; Region: HflX; cd01878
563174003901	G1 box; other site
563174003902	GTP/Mg2+ binding site [chemical binding]; other site
563174003903	Switch I region; other site
563174003904	G2 box; other site
563174003905	G3 box; other site
563174003906	Switch II region; other site
563174003907	G4 box; other site
563174003908	G5 box; other site
563174003909	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
563174003910	Aluminium resistance protein; Region: Alum_res; pfam06838
563174003911	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
563174003912	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
563174003913	DNA binding residues [nucleotide binding]
563174003914	putative dimer interface [polypeptide binding]; other site
563174003915	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
563174003916	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
563174003917	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
563174003918	arsenical pump membrane protein; Provisional; Region: PRK15445
563174003919	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
563174003920	transmembrane helices; other site
563174003921	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
563174003922	LexA repressor; Validated; Region: PRK00215
563174003923	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
563174003924	putative DNA binding site [nucleotide binding]; other site
563174003925	putative Zn2+ binding site [ion binding]; other site
563174003926	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
563174003927	Catalytic site [active]
563174003928	cell division suppressor protein YneA; Provisional; Region: PRK14125
563174003929	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
563174003930	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
563174003931	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
563174003932	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
563174003933	TPP-binding site [chemical binding]; other site
563174003934	dimer interface [polypeptide binding]; other site
563174003935	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
563174003936	PYR/PP interface [polypeptide binding]; other site
563174003937	dimer interface [polypeptide binding]; other site
563174003938	TPP binding site [chemical binding]; other site
563174003939	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
563174003940	hypothetical protein; Provisional; Region: PRK01844
563174003941	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
563174003942	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
563174003943	Methyltransferase domain; Region: Methyltransf_31; pfam13847
563174003944	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174003945	S-adenosylmethionine binding site [chemical binding]; other site
563174003946	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
563174003947	ParB-like nuclease domain; Region: ParBc; pfam02195
563174003948	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
563174003949	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
563174003950	Active Sites [active]
563174003951	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
563174003952	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
563174003953	DEAD-like helicases superfamily; Region: DEXDc; smart00487
563174003954	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
563174003955	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
563174003956	putative nucleotide binding site [chemical binding]; other site
563174003957	uridine monophosphate binding site [chemical binding]; other site
563174003958	homohexameric interface [polypeptide binding]; other site
563174003959	ribosome recycling factor; Reviewed; Region: frr; PRK00083
563174003960	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
563174003961	hinge region; other site
563174003962	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
563174003963	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
563174003964	catalytic residue [active]
563174003965	putative FPP diphosphate  binding site; other site
563174003966	putative FPP binding hydrophobic cleft; other site
563174003967	dimer interface [polypeptide binding]; other site
563174003968	putative IPP diphosphate binding site; other site
563174003969	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
563174003970	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
563174003971	1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743
563174003972	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
563174003973	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
563174003974	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
563174003975	RIP metalloprotease RseP; Region: TIGR00054
563174003976	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
563174003977	active site
563174003978	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
563174003979	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
563174003980	protein binding site [polypeptide binding]; other site
563174003981	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
563174003982	putative substrate binding region [chemical binding]; other site
563174003983	prolyl-tRNA synthetase; Provisional; Region: PRK09194
563174003984	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
563174003985	dimer interface [polypeptide binding]; other site
563174003986	motif 1; other site
563174003987	active site
563174003988	motif 2; other site
563174003989	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
563174003990	putative deacylase active site [active]
563174003991	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
563174003992	active site
563174003993	motif 3; other site
563174003994	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
563174003995	anticodon binding site; other site
563174003996	DNA polymerase III PolC; Validated; Region: polC; PRK00448
563174003997	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
563174003998	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
563174003999	generic binding surface II; other site
563174004000	generic binding surface I; other site
563174004001	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
563174004002	active site
563174004003	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
563174004004	active site
563174004005	catalytic site [active]
563174004006	substrate binding site [chemical binding]; other site
563174004007	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
563174004008	ribosome maturation protein RimP; Reviewed; Region: PRK00092
563174004009	Sm and related proteins; Region: Sm_like; cl00259
563174004010	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
563174004011	putative oligomer interface [polypeptide binding]; other site
563174004012	putative RNA binding site [nucleotide binding]; other site
563174004013	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
563174004014	NusA N-terminal domain; Region: NusA_N; pfam08529
563174004015	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
563174004016	RNA binding site [nucleotide binding]; other site
563174004017	homodimer interface [polypeptide binding]; other site
563174004018	NusA-like KH domain; Region: KH_5; pfam13184
563174004019	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
563174004020	G-X-X-G motif; other site
563174004021	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
563174004022	putative RNA binding cleft [nucleotide binding]; other site
563174004023	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
563174004024	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
563174004025	translation initiation factor IF-2; Region: IF-2; TIGR00487
563174004026	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
563174004027	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
563174004028	G1 box; other site
563174004029	putative GEF interaction site [polypeptide binding]; other site
563174004030	GTP/Mg2+ binding site [chemical binding]; other site
563174004031	Switch I region; other site
563174004032	G2 box; other site
563174004033	G3 box; other site
563174004034	Switch II region; other site
563174004035	G4 box; other site
563174004036	G5 box; other site
563174004037	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
563174004038	Translation-initiation factor 2; Region: IF-2; pfam11987
563174004039	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
563174004040	Protein of unknown function (DUF503); Region: DUF503; cl00669
563174004041	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
563174004042	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
563174004043	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
563174004044	RNA binding site [nucleotide binding]; other site
563174004045	active site
563174004046	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
563174004047	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
563174004048	active site
563174004049	Riboflavin kinase; Region: Flavokinase; smart00904
563174004050	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
563174004051	16S/18S rRNA binding site [nucleotide binding]; other site
563174004052	S13e-L30e interaction site [polypeptide binding]; other site
563174004053	25S rRNA binding site [nucleotide binding]; other site
563174004054	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
563174004055	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
563174004056	RNase E interface [polypeptide binding]; other site
563174004057	trimer interface [polypeptide binding]; other site
563174004058	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
563174004059	RNase E interface [polypeptide binding]; other site
563174004060	trimer interface [polypeptide binding]; other site
563174004061	active site
563174004062	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
563174004063	putative nucleic acid binding region [nucleotide binding]; other site
563174004064	G-X-X-G motif; other site
563174004065	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
563174004066	RNA binding site [nucleotide binding]; other site
563174004067	domain interface; other site
563174004068	GTPase RsgA; Reviewed; Region: PRK01889
563174004069	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
563174004070	RNA binding site [nucleotide binding]; other site
563174004071	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
563174004072	GTPase/Zn-binding domain interface [polypeptide binding]; other site
563174004073	GTP/Mg2+ binding site [chemical binding]; other site
563174004074	G4 box; other site
563174004075	G5 box; other site
563174004076	G1 box; other site
563174004077	Switch I region; other site
563174004078	G2 box; other site
563174004079	G3 box; other site
563174004080	Switch II region; other site
563174004081	YceG-like family; Region: YceG; pfam02618
563174004082	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
563174004083	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
563174004084	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
563174004085	Rhomboid family; Region: Rhomboid; pfam01694
563174004086	TPR repeat; Region: TPR_11; pfam13414
563174004087	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
563174004088	TPR motif; other site
563174004089	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
563174004090	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
563174004091	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
563174004092	nucleotide binding site [chemical binding]; other site
563174004093	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
563174004094	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
563174004095	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
563174004096	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
563174004097	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
563174004098	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
563174004099	Type II/IV secretion system protein; Region: T2SE; pfam00437
563174004100	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
563174004101	Walker A motif; other site
563174004102	ATP binding site [chemical binding]; other site
563174004103	Walker B motif; other site
563174004104	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
563174004105	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
563174004106	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
563174004107	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
563174004108	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
563174004109	tetramer interface [polypeptide binding]; other site
563174004110	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174004111	catalytic residue [active]
563174004112	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
563174004113	tetramer interface [polypeptide binding]; other site
563174004114	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174004115	catalytic residue [active]
563174004116	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
563174004117	active site residue [active]
563174004118	Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872
563174004119	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
563174004120	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
563174004121	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
563174004122	active site
563174004123	elongation factor P; Validated; Region: PRK00529
563174004124	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
563174004125	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
563174004126	RNA binding site [nucleotide binding]; other site
563174004127	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
563174004128	RNA binding site [nucleotide binding]; other site
563174004129	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
563174004130	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
563174004131	carboxyltransferase (CT) interaction site; other site
563174004132	biotinylation site [posttranslational modification]; other site
563174004133	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
563174004134	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
563174004135	ATP-grasp domain; Region: ATP-grasp_4; cl17255
563174004136	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
563174004137	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
563174004138	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
563174004139	putative RNA binding site [nucleotide binding]; other site
563174004140	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170
563174004141	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
563174004142	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
563174004143	homodimer interface [polypeptide binding]; other site
563174004144	NADP binding site [chemical binding]; other site
563174004145	substrate binding site [chemical binding]; other site
563174004146	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
563174004147	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
563174004148	generic binding surface II; other site
563174004149	generic binding surface I; other site
563174004150	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064
563174004151	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
563174004152	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
563174004153	substrate binding pocket [chemical binding]; other site
563174004154	chain length determination region; other site
563174004155	substrate-Mg2+ binding site; other site
563174004156	catalytic residues [active]
563174004157	aspartate-rich region 1; other site
563174004158	active site lid residues [active]
563174004159	aspartate-rich region 2; other site
563174004160	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
563174004161	DNA-binding site [nucleotide binding]; DNA binding site
563174004162	RNA-binding motif; other site
563174004163	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
563174004164	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
563174004165	TPP-binding site; other site
563174004166	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
563174004167	PYR/PP interface [polypeptide binding]; other site
563174004168	dimer interface [polypeptide binding]; other site
563174004169	TPP binding site [chemical binding]; other site
563174004170	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
563174004171	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
563174004172	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
563174004173	RNA binding surface [nucleotide binding]; other site
563174004174	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
563174004175	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
563174004176	arginine repressor; Provisional; Region: PRK04280
563174004177	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
563174004178	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
563174004179	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
563174004180	Walker A/P-loop; other site
563174004181	ATP binding site [chemical binding]; other site
563174004182	Q-loop/lid; other site
563174004183	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
563174004184	ABC transporter signature motif; other site
563174004185	Walker B; other site
563174004186	D-loop; other site
563174004187	H-loop/switch region; other site
563174004188	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
563174004189	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
563174004190	nucleotide binding site [chemical binding]; other site
563174004191	Acetokinase family; Region: Acetate_kinase; cl17229
563174004192	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
563174004193	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
563174004194	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
563174004195	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
563174004196	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
563174004197	tetramer interface [polypeptide binding]; other site
563174004198	TPP-binding site [chemical binding]; other site
563174004199	heterodimer interface [polypeptide binding]; other site
563174004200	phosphorylation loop region [posttranslational modification]
563174004201	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
563174004202	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
563174004203	alpha subunit interface [polypeptide binding]; other site
563174004204	TPP binding site [chemical binding]; other site
563174004205	heterodimer interface [polypeptide binding]; other site
563174004206	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
563174004207	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
563174004208	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
563174004209	E3 interaction surface; other site
563174004210	lipoyl attachment site [posttranslational modification]; other site
563174004211	e3 binding domain; Region: E3_binding; pfam02817
563174004212	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
563174004213	peptidase T-like protein; Region: PepT-like; TIGR01883
563174004214	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
563174004215	metal binding site [ion binding]; metal-binding site
563174004216	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
563174004217	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
563174004218	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
563174004219	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
563174004220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174004221	active site
563174004222	phosphorylation site [posttranslational modification]
563174004223	intermolecular recognition site; other site
563174004224	dimerization interface [polypeptide binding]; other site
563174004225	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
563174004226	DNA binding site [nucleotide binding]
563174004227	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
563174004228	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
563174004229	dimerization interface [polypeptide binding]; other site
563174004230	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
563174004231	dimer interface [polypeptide binding]; other site
563174004232	phosphorylation site [posttranslational modification]
563174004233	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174004234	ATP binding site [chemical binding]; other site
563174004235	Mg2+ binding site [ion binding]; other site
563174004236	G-X-G motif; other site
563174004237	OxaA-like protein precursor; Validated; Region: PRK01622
563174004238	acylphosphatase; Provisional; Region: PRK14443
563174004239	Protein of unknown function (DUF1033); Region: DUF1033; cl11549
563174004240	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
563174004241	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
563174004242	homotetramer interface [polypeptide binding]; other site
563174004243	FMN binding site [chemical binding]; other site
563174004244	homodimer contacts [polypeptide binding]; other site
563174004245	putative active site [active]
563174004246	putative substrate binding site [chemical binding]; other site
563174004247	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
563174004248	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
563174004249	active site residue [active]
563174004250	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
563174004251	Uncharacterized conserved protein [Function unknown]; Region: COG1284
563174004252	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
563174004253	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
563174004254	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
563174004255	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
563174004256	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
563174004257	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
563174004258	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928
563174004259	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
563174004260	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
563174004261	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
563174004262	ligand binding site [chemical binding]; other site
563174004263	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
563174004264	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
563174004265	Walker A/P-loop; other site
563174004266	ATP binding site [chemical binding]; other site
563174004267	Q-loop/lid; other site
563174004268	ABC transporter signature motif; other site
563174004269	Walker B; other site
563174004270	D-loop; other site
563174004271	H-loop/switch region; other site
563174004272	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
563174004273	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
563174004274	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
563174004275	TM-ABC transporter signature motif; other site
563174004276	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
563174004277	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
563174004278	TM-ABC transporter signature motif; other site
563174004279	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
563174004280	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
563174004281	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
563174004282	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
563174004283	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
563174004284	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
563174004285	classical (c) SDRs; Region: SDR_c; cd05233
563174004286	NAD(P) binding site [chemical binding]; other site
563174004287	active site
563174004288	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
563174004289	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174004290	non-specific DNA binding site [nucleotide binding]; other site
563174004291	salt bridge; other site
563174004292	sequence-specific DNA binding site [nucleotide binding]; other site
563174004293	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
563174004294	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
563174004295	competence damage-inducible protein A; Provisional; Region: PRK00549
563174004296	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
563174004297	putative MPT binding site; other site
563174004298	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
563174004299	recombinase A; Provisional; Region: recA; PRK09354
563174004300	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
563174004301	hexamer interface [polypeptide binding]; other site
563174004302	Walker A motif; other site
563174004303	ATP binding site [chemical binding]; other site
563174004304	Walker B motif; other site
563174004305	phosphodiesterase; Provisional; Region: PRK12704
563174004306	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
563174004307	Zn2+ binding site [ion binding]; other site
563174004308	Mg2+ binding site [ion binding]; other site
563174004309	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
563174004310	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174004311	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
563174004312	Coenzyme A binding pocket [chemical binding]; other site
563174004313	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
563174004314	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
563174004315	putative active site [active]
563174004316	metal binding site [ion binding]; metal-binding site
563174004317	homodimer binding site [polypeptide binding]; other site
563174004318	Predicted membrane protein [Function unknown]; Region: COG4550
563174004319	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
563174004320	MutS domain I; Region: MutS_I; pfam01624
563174004321	MutS domain II; Region: MutS_II; pfam05188
563174004322	MutS domain III; Region: MutS_III; pfam05192
563174004323	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
563174004324	Walker A/P-loop; other site
563174004325	ATP binding site [chemical binding]; other site
563174004326	Q-loop/lid; other site
563174004327	ABC transporter signature motif; other site
563174004328	Walker B; other site
563174004329	D-loop; other site
563174004330	H-loop/switch region; other site
563174004331	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
563174004332	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174004333	ATP binding site [chemical binding]; other site
563174004334	Mg2+ binding site [ion binding]; other site
563174004335	G-X-G motif; other site
563174004336	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
563174004337	ATP binding site [chemical binding]; other site
563174004338	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
563174004339	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
563174004340	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
563174004341	Pyruvate formate lyase 1; Region: PFL1; cd01678
563174004342	coenzyme A binding site [chemical binding]; other site
563174004343	active site
563174004344	catalytic residues [active]
563174004345	glycine loop; other site
563174004346	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
563174004347	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
563174004348	FeS/SAM binding site; other site
563174004349	Predicted transcriptional regulators [Transcription]; Region: COG1695
563174004350	Transcriptional regulator PadR-like family; Region: PadR; cl17335
563174004351	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174004352	Major Facilitator Superfamily; Region: MFS_1; pfam07690
563174004353	putative substrate translocation pore; other site
563174004354	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174004355	non-specific DNA binding site [nucleotide binding]; other site
563174004356	salt bridge; other site
563174004357	sequence-specific DNA binding site [nucleotide binding]; other site
563174004358	topology modulation protein; Reviewed; Region: PRK08118
563174004359	AAA domain; Region: AAA_17; pfam13207
563174004360	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174004361	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174004362	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174004363	putative acyltransferase; Provisional; Region: PRK05790
563174004364	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
563174004365	dimer interface [polypeptide binding]; other site
563174004366	active site
563174004367	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
563174004368	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
563174004369	dimer interface [polypeptide binding]; other site
563174004370	active site
563174004371	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
563174004372	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
563174004373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174004374	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
563174004375	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
563174004376	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
563174004377	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
563174004378	FAD binding domain; Region: FAD_binding_4; pfam01565
563174004379	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
563174004380	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
563174004381	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
563174004382	Walker A/P-loop; other site
563174004383	ATP binding site [chemical binding]; other site
563174004384	Q-loop/lid; other site
563174004385	ABC transporter signature motif; other site
563174004386	Walker B; other site
563174004387	D-loop; other site
563174004388	H-loop/switch region; other site
563174004389	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
563174004390	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174004391	dimer interface [polypeptide binding]; other site
563174004392	conserved gate region; other site
563174004393	ABC-ATPase subunit interface; other site
563174004394	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
563174004395	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
563174004396	manganese transport protein MntH; Reviewed; Region: PRK00701
563174004397	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
563174004398	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174004399	dimer interface [polypeptide binding]; other site
563174004400	conserved gate region; other site
563174004401	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
563174004402	ABC-ATPase subunit interface; other site
563174004403	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
563174004404	LysR substrate binding domain; Region: LysR_substrate; pfam03466
563174004405	dimerization interface [polypeptide binding]; other site
563174004406	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174004407	dimer interface [polypeptide binding]; other site
563174004408	conserved gate region; other site
563174004409	putative PBP binding loops; other site
563174004410	ABC-ATPase subunit interface; other site
563174004411	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
563174004412	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
563174004413	Walker A/P-loop; other site
563174004414	ATP binding site [chemical binding]; other site
563174004415	Q-loop/lid; other site
563174004416	ABC transporter signature motif; other site
563174004417	Walker B; other site
563174004418	D-loop; other site
563174004419	H-loop/switch region; other site
563174004420	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
563174004421	Predicted membrane protein [Function unknown]; Region: COG3859
563174004422	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
563174004423	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
563174004424	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
563174004425	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
563174004426	ABC transporter; Region: ABC_tran_2; pfam12848
563174004427	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
563174004428	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
563174004429	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
563174004430	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
563174004431	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
563174004432	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
563174004433	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
563174004434	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
563174004435	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
563174004436	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
563174004437	dihydrodipicolinate synthase; Region: dapA; TIGR00674
563174004438	dimer interface [polypeptide binding]; other site
563174004439	active site
563174004440	catalytic residue [active]
563174004441	aspartate kinase I; Reviewed; Region: PRK08210
563174004442	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
563174004443	nucleotide binding site [chemical binding]; other site
563174004444	substrate binding site [chemical binding]; other site
563174004445	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
563174004446	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
563174004447	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
563174004448	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
563174004449	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
563174004450	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
563174004451	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
563174004452	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
563174004453	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
563174004454	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
563174004455	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
563174004456	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
563174004457	Predicted membrane protein [Function unknown]; Region: COG4392
563174004458	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
563174004459	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
563174004460	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
563174004461	metal binding site 2 [ion binding]; metal-binding site
563174004462	putative DNA binding helix; other site
563174004463	metal binding site 1 [ion binding]; metal-binding site
563174004464	dimer interface [polypeptide binding]; other site
563174004465	structural Zn2+ binding site [ion binding]; other site
563174004466	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
563174004467	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
563174004468	ABC-ATPase subunit  interface; other site
563174004469	dimer interface [polypeptide binding]; other site
563174004470	putative PBP binding regions; other site
563174004471	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
563174004472	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
563174004473	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
563174004474	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
563174004475	DHHA2 domain; Region: DHHA2; pfam02833
563174004476	endonuclease IV; Provisional; Region: PRK01060
563174004477	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
563174004478	AP (apurinic/apyrimidinic) site pocket; other site
563174004479	DNA interaction; other site
563174004480	Metal-binding active site; metal-binding site
563174004481	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
563174004482	DEAD-like helicases superfamily; Region: DEXDc; smart00487
563174004483	ATP binding site [chemical binding]; other site
563174004484	Mg++ binding site [ion binding]; other site
563174004485	motif III; other site
563174004486	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
563174004487	nucleotide binding region [chemical binding]; other site
563174004488	ATP-binding site [chemical binding]; other site
563174004489	Uncharacterized conserved protein [Function unknown]; Region: COG0327
563174004490	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
563174004491	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
563174004492	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
563174004493	Uncharacterized conserved protein [Function unknown]; Region: COG0327
563174004494	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
563174004495	Family of unknown function (DUF633); Region: DUF633; pfam04816
563174004496	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
563174004497	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
563174004498	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
563174004499	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
563174004500	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
563174004501	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
563174004502	DNA binding residues [nucleotide binding]
563174004503	DNA primase; Validated; Region: dnaG; PRK05667
563174004504	CHC2 zinc finger; Region: zf-CHC2; pfam01807
563174004505	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
563174004506	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
563174004507	active site
563174004508	metal binding site [ion binding]; metal-binding site
563174004509	interdomain interaction site; other site
563174004510	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
563174004511	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
563174004512	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
563174004513	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
563174004514	DALR anticodon binding domain; Region: DALR_1; pfam05746
563174004515	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
563174004516	dimer interface [polypeptide binding]; other site
563174004517	motif 1; other site
563174004518	active site
563174004519	motif 2; other site
563174004520	motif 3; other site
563174004521	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
563174004522	Recombination protein O N terminal; Region: RecO_N; pfam11967
563174004523	Recombination protein O C terminal; Region: RecO_C; pfam02565
563174004524	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
563174004525	GTPase Era; Reviewed; Region: era; PRK00089
563174004526	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
563174004527	G1 box; other site
563174004528	GTP/Mg2+ binding site [chemical binding]; other site
563174004529	Switch I region; other site
563174004530	G2 box; other site
563174004531	Switch II region; other site
563174004532	G3 box; other site
563174004533	G4 box; other site
563174004534	G5 box; other site
563174004535	KH domain; Region: KH_2; pfam07650
563174004536	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
563174004537	active site
563174004538	catalytic motif [active]
563174004539	Zn binding site [ion binding]; other site
563174004540	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
563174004541	metal-binding heat shock protein; Provisional; Region: PRK00016
563174004542	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
563174004543	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
563174004544	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
563174004545	Zn2+ binding site [ion binding]; other site
563174004546	Mg2+ binding site [ion binding]; other site
563174004547	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
563174004548	PhoH-like protein; Region: PhoH; pfam02562
563174004549	Yqey-like protein; Region: YqeY; pfam09424
563174004550	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
563174004551	RNA methyltransferase, RsmE family; Region: TIGR00046
563174004552	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
563174004553	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
563174004554	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174004555	S-adenosylmethionine binding site [chemical binding]; other site
563174004556	chaperone protein DnaJ; Provisional; Region: PRK14280
563174004557	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
563174004558	HSP70 interaction site [polypeptide binding]; other site
563174004559	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
563174004560	substrate binding site [polypeptide binding]; other site
563174004561	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
563174004562	Zn binding sites [ion binding]; other site
563174004563	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
563174004564	dimer interface [polypeptide binding]; other site
563174004565	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
563174004566	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
563174004567	nucleotide binding site [chemical binding]; other site
563174004568	NEF interaction site [polypeptide binding]; other site
563174004569	SBD interface [polypeptide binding]; other site
563174004570	heat shock protein GrpE; Provisional; Region: PRK14140
563174004571	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
563174004572	dimer interface [polypeptide binding]; other site
563174004573	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
563174004574	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
563174004575	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
563174004576	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
563174004577	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
563174004578	FeS/SAM binding site; other site
563174004579	HemN C-terminal domain; Region: HemN_C; pfam06969
563174004580	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
563174004581	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
563174004582	NADP binding site [chemical binding]; other site
563174004583	putative substrate binding site [chemical binding]; other site
563174004584	active site
563174004585	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
563174004586	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
563174004587	DNA binding residues [nucleotide binding]
563174004588	putative dimer interface [polypeptide binding]; other site
563174004589	GTP-binding protein LepA; Provisional; Region: PRK05433
563174004590	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
563174004591	G1 box; other site
563174004592	putative GEF interaction site [polypeptide binding]; other site
563174004593	GTP/Mg2+ binding site [chemical binding]; other site
563174004594	Switch I region; other site
563174004595	G2 box; other site
563174004596	G3 box; other site
563174004597	Switch II region; other site
563174004598	G4 box; other site
563174004599	G5 box; other site
563174004600	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
563174004601	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
563174004602	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
563174004603	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
563174004604	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
563174004605	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
563174004606	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
563174004607	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
563174004608	Competence protein; Region: Competence; pfam03772
563174004609	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
563174004610	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
563174004611	catalytic motif [active]
563174004612	Zn binding site [ion binding]; other site
563174004613	SLBB domain; Region: SLBB; pfam10531
563174004614	comEA protein; Region: comE; TIGR01259
563174004615	Helix-hairpin-helix motif; Region: HHH; pfam00633
563174004616	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
563174004617	DNA binding site [nucleotide binding]
563174004618	Methyltransferase domain; Region: Methyltransf_23; pfam13489
563174004619	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174004620	S-adenosylmethionine binding site [chemical binding]; other site
563174004621	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
563174004622	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
563174004623	Zn2+ binding site [ion binding]; other site
563174004624	Mg2+ binding site [ion binding]; other site
563174004625	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
563174004626	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
563174004627	active site
563174004628	(T/H)XGH motif; other site
563174004629	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
563174004630	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
563174004631	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
563174004632	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
563174004633	shikimate binding site; other site
563174004634	NAD(P) binding site [chemical binding]; other site
563174004635	GTPase YqeH; Provisional; Region: PRK13796
563174004636	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
563174004637	GTP/Mg2+ binding site [chemical binding]; other site
563174004638	G4 box; other site
563174004639	G5 box; other site
563174004640	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
563174004641	G1 box; other site
563174004642	G1 box; other site
563174004643	GTP/Mg2+ binding site [chemical binding]; other site
563174004644	G2 box; other site
563174004645	Switch I region; other site
563174004646	G2 box; other site
563174004647	Switch I region; other site
563174004648	G3 box; other site
563174004649	G3 box; other site
563174004650	Switch II region; other site
563174004651	Switch II region; other site
563174004652	G4 box; other site
563174004653	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
563174004654	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174004655	motif II; other site
563174004656	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
563174004657	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
563174004658	active site
563174004659	Zn binding site [ion binding]; other site
563174004660	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
563174004661	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
563174004662	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
563174004663	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
563174004664	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
563174004665	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
563174004666	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
563174004667	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
563174004668	Sugar specificity; other site
563174004669	Pyrimidine base specificity; other site
563174004670	ATP-binding site [chemical binding]; other site
563174004671	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
563174004672	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174004673	S-adenosylmethionine binding site [chemical binding]; other site
563174004674	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
563174004675	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
563174004676	dimerization interface [polypeptide binding]; other site
563174004677	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
563174004678	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
563174004679	hypothetical protein; Provisional; Region: PRK13678
563174004680	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
563174004681	hypothetical protein; Provisional; Region: PRK05473
563174004682	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
563174004683	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
563174004684	motif 1; other site
563174004685	active site
563174004686	motif 2; other site
563174004687	motif 3; other site
563174004688	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
563174004689	DHHA1 domain; Region: DHHA1; pfam02272
563174004690	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
563174004691	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
563174004692	Walker A/P-loop; other site
563174004693	ATP binding site [chemical binding]; other site
563174004694	Q-loop/lid; other site
563174004695	ABC transporter signature motif; other site
563174004696	Walker B; other site
563174004697	D-loop; other site
563174004698	H-loop/switch region; other site
563174004699	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
563174004700	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
563174004701	FtsX-like permease family; Region: FtsX; pfam02687
563174004702	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
563174004703	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174004704	active site
563174004705	phosphorylation site [posttranslational modification]
563174004706	intermolecular recognition site; other site
563174004707	dimerization interface [polypeptide binding]; other site
563174004708	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
563174004709	DNA binding site [nucleotide binding]
563174004710	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
563174004711	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
563174004712	dimerization interface [polypeptide binding]; other site
563174004713	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
563174004714	dimer interface [polypeptide binding]; other site
563174004715	phosphorylation site [posttranslational modification]
563174004716	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174004717	ATP binding site [chemical binding]; other site
563174004718	Mg2+ binding site [ion binding]; other site
563174004719	G-X-G motif; other site
563174004720	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
563174004721	AAA domain; Region: AAA_30; pfam13604
563174004722	Family description; Region: UvrD_C_2; pfam13538
563174004723	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
563174004724	binding surface
563174004725	TPR motif; other site
563174004726	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
563174004727	TPR repeat; Region: TPR_11; pfam13414
563174004728	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
563174004729	binding surface
563174004730	TPR motif; other site
563174004731	TPR repeat; Region: TPR_11; pfam13414
563174004732	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
563174004733	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
563174004734	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
563174004735	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
563174004736	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
563174004737	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
563174004738	catalytic residue [active]
563174004739	ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256
563174004740	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174004741	Walker A motif; other site
563174004742	ATP binding site [chemical binding]; other site
563174004743	Walker B motif; other site
563174004744	arginine finger; other site
563174004745	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
563174004746	Predicted transcriptional regulator [Transcription]; Region: COG1959
563174004747	Transcriptional regulator; Region: Rrf2; pfam02082
563174004748	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
563174004749	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
563174004750	Nitrogen regulatory protein P-II; Region: P-II; smart00938
563174004751	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
563174004752	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
563174004753	dimer interface [polypeptide binding]; other site
563174004754	anticodon binding site; other site
563174004755	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
563174004756	homodimer interface [polypeptide binding]; other site
563174004757	motif 1; other site
563174004758	active site
563174004759	motif 2; other site
563174004760	GAD domain; Region: GAD; pfam02938
563174004761	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
563174004762	motif 3; other site
563174004763	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
563174004764	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
563174004765	dimer interface [polypeptide binding]; other site
563174004766	motif 1; other site
563174004767	active site
563174004768	motif 2; other site
563174004769	motif 3; other site
563174004770	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
563174004771	anticodon binding site; other site
563174004772	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
563174004773	Bacterial SH3 domain; Region: SH3_3; pfam08239
563174004774	Bacterial SH3 domain; Region: SH3_3; pfam08239
563174004775	Bacterial SH3 domain homologues; Region: SH3b; smart00287
563174004776	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
563174004777	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
563174004778	active site
563174004779	metal binding site [ion binding]; metal-binding site
563174004780	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
563174004781	putative active site [active]
563174004782	dimerization interface [polypeptide binding]; other site
563174004783	putative tRNAtyr binding site [nucleotide binding]; other site
563174004784	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
563174004785	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
563174004786	Zn2+ binding site [ion binding]; other site
563174004787	Mg2+ binding site [ion binding]; other site
563174004788	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
563174004789	synthetase active site [active]
563174004790	NTP binding site [chemical binding]; other site
563174004791	metal binding site [ion binding]; metal-binding site
563174004792	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
563174004793	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
563174004794	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
563174004795	active site
563174004796	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
563174004797	DHH family; Region: DHH; pfam01368
563174004798	DHHA1 domain; Region: DHHA1; pfam02272
563174004799	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
563174004800	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
563174004801	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
563174004802	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
563174004803	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
563174004804	Protein export membrane protein; Region: SecD_SecF; pfam02355
563174004805	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
563174004806	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
563174004807	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
563174004808	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
563174004809	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
563174004810	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
563174004811	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
563174004812	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174004813	Walker A motif; other site
563174004814	ATP binding site [chemical binding]; other site
563174004815	Walker B motif; other site
563174004816	arginine finger; other site
563174004817	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
563174004818	Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
563174004819	RuvA N terminal domain; Region: RuvA_N; pfam01330
563174004820	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
563174004821	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
563174004822	tetramer (dimer of dimers) interface [polypeptide binding]; other site
563174004823	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
563174004824	NAD binding site [chemical binding]; other site
563174004825	dimer interface [polypeptide binding]; other site
563174004826	substrate binding site [chemical binding]; other site
563174004827	hypothetical protein; Validated; Region: PRK00110
563174004828	prephenate dehydratase; Provisional; Region: PRK11898
563174004829	Prephenate dehydratase; Region: PDT; pfam00800
563174004830	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
563174004831	putative L-Phe binding site [chemical binding]; other site
563174004832	GTPase CgtA; Reviewed; Region: obgE; PRK12297
563174004833	GTP1/OBG; Region: GTP1_OBG; pfam01018
563174004834	Obg GTPase; Region: Obg; cd01898
563174004835	G1 box; other site
563174004836	GTP/Mg2+ binding site [chemical binding]; other site
563174004837	Switch I region; other site
563174004838	G2 box; other site
563174004839	G3 box; other site
563174004840	Switch II region; other site
563174004841	G4 box; other site
563174004842	G5 box; other site
563174004843	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
563174004844	glycerol kinase; Provisional; Region: glpK; PRK00047
563174004845	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
563174004846	N- and C-terminal domain interface [polypeptide binding]; other site
563174004847	active site
563174004848	MgATP binding site [chemical binding]; other site
563174004849	catalytic site [active]
563174004850	metal binding site [ion binding]; metal-binding site
563174004851	glycerol binding site [chemical binding]; other site
563174004852	homotetramer interface [polypeptide binding]; other site
563174004853	homodimer interface [polypeptide binding]; other site
563174004854	FBP binding site [chemical binding]; other site
563174004855	protein IIAGlc interface [polypeptide binding]; other site
563174004856	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
563174004857	amphipathic channel; other site
563174004858	Asn-Pro-Ala signature motifs; other site
563174004859	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
563174004860	hypothetical protein; Provisional; Region: PRK14553
563174004861	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
563174004862	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
563174004863	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
563174004864	homodimer interface [polypeptide binding]; other site
563174004865	oligonucleotide binding site [chemical binding]; other site
563174004866	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
563174004867	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
563174004868	Switch I; other site
563174004869	Switch II; other site
563174004870	septum formation inhibitor; Reviewed; Region: minC; PRK00513
563174004871	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
563174004872	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
563174004873	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
563174004874	Protein of unknown function (DUF972); Region: DUF972; pfam06156
563174004875	rod shape-determining protein MreC; Region: MreC; pfam04085
563174004876	rod shape-determining protein MreB; Provisional; Region: PRK13927
563174004877	MreB and similar proteins; Region: MreB_like; cd10225
563174004878	nucleotide binding site [chemical binding]; other site
563174004879	Mg binding site [ion binding]; other site
563174004880	putative protofilament interaction site [polypeptide binding]; other site
563174004881	RodZ interaction site [polypeptide binding]; other site
563174004882	hypothetical protein; Reviewed; Region: PRK00024
563174004883	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
563174004884	MPN+ (JAMM) motif; other site
563174004885	Zinc-binding site [ion binding]; other site
563174004886	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
563174004887	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
563174004888	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
563174004889	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
563174004890	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
563174004891	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
563174004892	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
563174004893	active site
563174004894	HIGH motif; other site
563174004895	nucleotide binding site [chemical binding]; other site
563174004896	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
563174004897	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
563174004898	active site
563174004899	KMSKS motif; other site
563174004900	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
563174004901	tRNA binding surface [nucleotide binding]; other site
563174004902	anticodon binding site; other site
563174004903	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
563174004904	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
563174004905	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
563174004906	inhibitor-cofactor binding pocket; inhibition site
563174004907	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174004908	catalytic residue [active]
563174004909	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
563174004910	dimer interface [polypeptide binding]; other site
563174004911	active site
563174004912	Schiff base residues; other site
563174004913	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
563174004914	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
563174004915	active site
563174004916	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
563174004917	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
563174004918	domain interfaces; other site
563174004919	active site
563174004920	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
563174004921	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
563174004922	tRNA; other site
563174004923	putative tRNA binding site [nucleotide binding]; other site
563174004924	putative NADP binding site [chemical binding]; other site
563174004925	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
563174004926	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
563174004927	G1 box; other site
563174004928	GTP/Mg2+ binding site [chemical binding]; other site
563174004929	Switch I region; other site
563174004930	G2 box; other site
563174004931	G3 box; other site
563174004932	Switch II region; other site
563174004933	G4 box; other site
563174004934	G5 box; other site
563174004935	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
563174004936	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
563174004937	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
563174004938	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
563174004939	active site
563174004940	dimer interface [polypeptide binding]; other site
563174004941	motif 1; other site
563174004942	motif 2; other site
563174004943	motif 3; other site
563174004944	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
563174004945	anticodon binding site; other site
563174004946	primosomal protein DnaI; Reviewed; Region: PRK08939
563174004947	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
563174004948	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
563174004949	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
563174004950	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
563174004951	ATP cone domain; Region: ATP-cone; pfam03477
563174004952	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
563174004953	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
563174004954	CoA-binding site [chemical binding]; other site
563174004955	ATP-binding [chemical binding]; other site
563174004956	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
563174004957	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
563174004958	DNA binding site [nucleotide binding]
563174004959	catalytic residue [active]
563174004960	H2TH interface [polypeptide binding]; other site
563174004961	putative catalytic residues [active]
563174004962	turnover-facilitating residue; other site
563174004963	intercalation triad [nucleotide binding]; other site
563174004964	8OG recognition residue [nucleotide binding]; other site
563174004965	putative reading head residues; other site
563174004966	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
563174004967	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
563174004968	DNA polymerase I; Provisional; Region: PRK05755
563174004969	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
563174004970	active site
563174004971	metal binding site 1 [ion binding]; metal-binding site
563174004972	putative 5' ssDNA interaction site; other site
563174004973	metal binding site 3; metal-binding site
563174004974	metal binding site 2 [ion binding]; metal-binding site
563174004975	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
563174004976	putative DNA binding site [nucleotide binding]; other site
563174004977	putative metal binding site [ion binding]; other site
563174004978	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
563174004979	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
563174004980	active site
563174004981	DNA binding site [nucleotide binding]
563174004982	catalytic site [active]
563174004983	isocitrate dehydrogenase; Reviewed; Region: PRK07006
563174004984	isocitrate dehydrogenase; Validated; Region: PRK07362
563174004985	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
563174004986	dimer interface [polypeptide binding]; other site
563174004987	Citrate synthase; Region: Citrate_synt; pfam00285
563174004988	active site
563174004989	citrylCoA binding site [chemical binding]; other site
563174004990	oxalacetate/citrate binding site [chemical binding]; other site
563174004991	coenzyme A binding site [chemical binding]; other site
563174004992	catalytic triad [active]
563174004993	Protein of unknown function (DUF441); Region: DUF441; pfam04284
563174004994	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
563174004995	pyruvate kinase; Provisional; Region: PRK06354
563174004996	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
563174004997	domain interfaces; other site
563174004998	active site
563174004999	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
563174005000	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
563174005001	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
563174005002	active site
563174005003	ADP/pyrophosphate binding site [chemical binding]; other site
563174005004	dimerization interface [polypeptide binding]; other site
563174005005	allosteric effector site; other site
563174005006	fructose-1,6-bisphosphate binding site; other site
563174005007	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
563174005008	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
563174005009	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
563174005010	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
563174005011	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
563174005012	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
563174005013	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
563174005014	active site
563174005015	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
563174005016	generic binding surface I; other site
563174005017	generic binding surface II; other site
563174005018	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
563174005019	DHH family; Region: DHH; pfam01368
563174005020	DHHA1 domain; Region: DHHA1; pfam02272
563174005021	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
563174005022	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
563174005023	DNA-binding site [nucleotide binding]; DNA binding site
563174005024	DRTGG domain; Region: DRTGG; pfam07085
563174005025	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
563174005026	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
563174005027	active site 2 [active]
563174005028	active site 1 [active]
563174005029	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
563174005030	metal-dependent hydrolase; Provisional; Region: PRK00685
563174005031	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
563174005032	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
563174005033	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
563174005034	active site
563174005035	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
563174005036	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
563174005037	hexamer interface [polypeptide binding]; other site
563174005038	ligand binding site [chemical binding]; other site
563174005039	putative active site [active]
563174005040	NAD(P) binding site [chemical binding]; other site
563174005041	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
563174005042	Ligand Binding Site [chemical binding]; other site
563174005043	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
563174005044	propionate/acetate kinase; Provisional; Region: PRK12379
563174005045	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
563174005046	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174005047	S-adenosylmethionine binding site [chemical binding]; other site
563174005048	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
563174005049	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
563174005050	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
563174005051	classical (c) SDRs; Region: SDR_c; cd05233
563174005052	NAD(P) binding site [chemical binding]; other site
563174005053	active site
563174005054	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
563174005055	DNA binding residues [nucleotide binding]
563174005056	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
563174005057	putative dimer interface [polypeptide binding]; other site
563174005058	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
563174005059	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
563174005060	putative catalytic residues [active]
563174005061	catalytic nucleophile [active]
563174005062	Recombinase; Region: Recombinase; pfam07508
563174005063	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
563174005064	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
563174005065	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
563174005066	dimer interface [polypeptide binding]; other site
563174005067	catalytic triad [active]
563174005068	peroxidatic and resolving cysteines [active]
563174005069	RDD family; Region: RDD; pfam06271
563174005070	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
563174005071	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
563174005072	tandem repeat interface [polypeptide binding]; other site
563174005073	oligomer interface [polypeptide binding]; other site
563174005074	active site residues [active]
563174005075	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
563174005076	ATP-NAD kinase; Region: NAD_kinase; pfam01513
563174005077	ornithine carbamoyltransferase; Provisional; Region: PRK00779
563174005078	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
563174005079	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
563174005080	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
563174005081	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
563174005082	inhibitor-cofactor binding pocket; inhibition site
563174005083	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174005084	catalytic residue [active]
563174005085	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
563174005086	nucleotide binding site [chemical binding]; other site
563174005087	N-acetyl-L-glutamate binding site [chemical binding]; other site
563174005088	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
563174005089	heterotetramer interface [polypeptide binding]; other site
563174005090	active site pocket [active]
563174005091	cleavage site
563174005092	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
563174005093	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
563174005094	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
563174005095	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
563174005096	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
563174005097	Ligand Binding Site [chemical binding]; other site
563174005098	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
563174005099	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
563174005100	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
563174005101	catalytic residue [active]
563174005102	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
563174005103	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
563174005104	GAF domain; Region: GAF_2; pfam13185
563174005105	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
563174005106	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
563174005107	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
563174005108	RNA binding surface [nucleotide binding]; other site
563174005109	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
563174005110	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
563174005111	active site
563174005112	HIGH motif; other site
563174005113	dimer interface [polypeptide binding]; other site
563174005114	KMSKS motif; other site
563174005115	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
563174005116	RNA binding surface [nucleotide binding]; other site
563174005117	catabolite control protein A; Region: ccpA; TIGR01481
563174005118	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
563174005119	DNA binding site [nucleotide binding]
563174005120	domain linker motif; other site
563174005121	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
563174005122	dimerization interface [polypeptide binding]; other site
563174005123	effector binding site; other site
563174005124	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
563174005125	Chorismate mutase type II; Region: CM_2; cl00693
563174005126	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
563174005127	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
563174005128	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
563174005129	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
563174005130	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
563174005131	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
563174005132	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
563174005133	dimer interface [polypeptide binding]; other site
563174005134	decamer (pentamer of dimers) interface [polypeptide binding]; other site
563174005135	catalytic triad [active]
563174005136	peroxidatic and resolving cysteines [active]
563174005137	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
563174005138	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
563174005139	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
563174005140	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
563174005141	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
563174005142	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
563174005143	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
563174005144	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
563174005145	putative tRNA-binding site [nucleotide binding]; other site
563174005146	hypothetical protein; Provisional; Region: PRK13668
563174005147	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
563174005148	catalytic residues [active]
563174005149	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
563174005150	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
563174005151	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
563174005152	oligomer interface [polypeptide binding]; other site
563174005153	active site
563174005154	metal binding site [ion binding]; metal-binding site
563174005155	Predicted small secreted protein [Function unknown]; Region: COG5584
563174005156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937
563174005157	putative homodimer interface [polypeptide binding]; other site
563174005158	putative homotetramer interface [polypeptide binding]; other site
563174005159	putative allosteric switch controlling residues; other site
563174005160	putative metal binding site [ion binding]; other site
563174005161	putative homodimer-homodimer interface [polypeptide binding]; other site
563174005162	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
563174005163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174005164	S-adenosylmethionine binding site [chemical binding]; other site
563174005165	Phosphotransferase enzyme family; Region: APH; pfam01636
563174005166	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
563174005167	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
563174005168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174005169	putative substrate translocation pore; other site
563174005170	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174005171	MarR family; Region: MarR; pfam01047
563174005172	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
563174005173	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
563174005174	homodimer interface [polypeptide binding]; other site
563174005175	substrate-cofactor binding pocket; other site
563174005176	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174005177	catalytic residue [active]
563174005178	dipeptidase PepV; Reviewed; Region: PRK07318
563174005179	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
563174005180	active site
563174005181	metal binding site [ion binding]; metal-binding site
563174005182	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699
563174005183	nudix motif; other site
563174005184	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
563174005185	putative substrate binding site [chemical binding]; other site
563174005186	putative ATP binding site [chemical binding]; other site
563174005187	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
563174005188	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
563174005189	active site
563174005190	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
563174005191	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
563174005192	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
563174005193	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
563174005194	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
563174005195	substrate binding site [chemical binding]; other site
563174005196	active site
563174005197	catalytic residues [active]
563174005198	heterodimer interface [polypeptide binding]; other site
563174005199	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
563174005200	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
563174005201	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174005202	catalytic residue [active]
563174005203	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
563174005204	active site
563174005205	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
563174005206	active site
563174005207	ribulose/triose binding site [chemical binding]; other site
563174005208	phosphate binding site [ion binding]; other site
563174005209	substrate (anthranilate) binding pocket [chemical binding]; other site
563174005210	product (indole) binding pocket [chemical binding]; other site
563174005211	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
563174005212	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
563174005213	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
563174005214	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
563174005215	Glutamine amidotransferase class-I; Region: GATase; pfam00117
563174005216	glutamine binding [chemical binding]; other site
563174005217	catalytic triad [active]
563174005218	anthranilate synthase component I; Provisional; Region: PRK13570
563174005219	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
563174005220	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
563174005221	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
563174005222	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
563174005223	putative catalytic cysteine [active]
563174005224	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
563174005225	putative active site [active]
563174005226	metal binding site [ion binding]; metal-binding site
563174005227	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
563174005228	dimer interface [polypeptide binding]; other site
563174005229	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
563174005230	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174005231	Walker A/P-loop; other site
563174005232	ATP binding site [chemical binding]; other site
563174005233	Q-loop/lid; other site
563174005234	ABC transporter signature motif; other site
563174005235	Walker B; other site
563174005236	D-loop; other site
563174005237	H-loop/switch region; other site
563174005238	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
563174005239	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
563174005240	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
563174005241	putative dimer interface [polypeptide binding]; other site
563174005242	catalytic triad [active]
563174005243	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
563174005244	aconitate hydratase; Validated; Region: PRK09277
563174005245	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
563174005246	substrate binding site [chemical binding]; other site
563174005247	ligand binding site [chemical binding]; other site
563174005248	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
563174005249	substrate binding site [chemical binding]; other site
563174005250	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
563174005251	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
563174005252	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
563174005253	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
563174005254	ATP binding site [chemical binding]; other site
563174005255	putative Mg++ binding site [ion binding]; other site
563174005256	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
563174005257	nucleotide binding region [chemical binding]; other site
563174005258	ATP-binding site [chemical binding]; other site
563174005259	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
563174005260	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
563174005261	Walker A/P-loop; other site
563174005262	ATP binding site [chemical binding]; other site
563174005263	Q-loop/lid; other site
563174005264	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
563174005265	ABC transporter signature motif; other site
563174005266	Walker B; other site
563174005267	D-loop; other site
563174005268	H-loop/switch region; other site
563174005269	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
563174005270	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
563174005271	active site
563174005272	metal binding site [ion binding]; metal-binding site
563174005273	DNA binding site [nucleotide binding]
563174005274	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
563174005275	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
563174005276	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
563174005277	putative acyl-acceptor binding pocket; other site
563174005278	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
563174005279	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
563174005280	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
563174005281	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
563174005282	Walker A/P-loop; other site
563174005283	ATP binding site [chemical binding]; other site
563174005284	Q-loop/lid; other site
563174005285	ABC transporter signature motif; other site
563174005286	Walker B; other site
563174005287	D-loop; other site
563174005288	H-loop/switch region; other site
563174005289	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
563174005290	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
563174005291	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174005292	Walker A/P-loop; other site
563174005293	ATP binding site [chemical binding]; other site
563174005294	Q-loop/lid; other site
563174005295	ABC transporter signature motif; other site
563174005296	Walker B; other site
563174005297	D-loop; other site
563174005298	H-loop/switch region; other site
563174005299	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
563174005300	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
563174005301	active site
563174005302	active site
563174005303	elongation factor Ts; Provisional; Region: tsf; PRK09377
563174005304	UBA/TS-N domain; Region: UBA; pfam00627
563174005305	Elongation factor TS; Region: EF_TS; pfam00889
563174005306	Elongation factor TS; Region: EF_TS; pfam00889
563174005307	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
563174005308	rRNA interaction site [nucleotide binding]; other site
563174005309	S8 interaction site; other site
563174005310	putative laminin-1 binding site; other site
563174005311	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
563174005312	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
563174005313	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
563174005314	HIGH motif; other site
563174005315	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
563174005316	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
563174005317	active site
563174005318	KMSKS motif; other site
563174005319	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
563174005320	tRNA binding surface [nucleotide binding]; other site
563174005321	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
563174005322	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
563174005323	FeS/SAM binding site; other site
563174005324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174005325	S-adenosylmethionine binding site [chemical binding]; other site
563174005326	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
563174005327	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
563174005328	active site
563174005329	dimer interface [polypeptide binding]; other site
563174005330	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
563174005331	Ligand Binding Site [chemical binding]; other site
563174005332	Molecular Tunnel; other site
563174005333	S-adenosylmethionine synthetase; Validated; Region: PRK05250
563174005334	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
563174005335	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
563174005336	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
563174005337	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
563174005338	tetramer (dimer of dimers) interface [polypeptide binding]; other site
563174005339	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
563174005340	NAD binding site [chemical binding]; other site
563174005341	dimer interface [polypeptide binding]; other site
563174005342	substrate binding site [chemical binding]; other site
563174005343	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
563174005344	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
563174005345	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
563174005346	nudix motif; other site
563174005347	Uncharacterized conserved protein [Function unknown]; Region: COG0759
563174005348	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
563174005349	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
563174005350	metal binding site [ion binding]; metal-binding site
563174005351	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
563174005352	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
563174005353	acyl-activating enzyme (AAE) consensus motif; other site
563174005354	putative AMP binding site [chemical binding]; other site
563174005355	putative active site [active]
563174005356	putative CoA binding site [chemical binding]; other site
563174005357	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
563174005358	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
563174005359	substrate binding site [chemical binding]; other site
563174005360	oxyanion hole (OAH) forming residues; other site
563174005361	trimer interface [polypeptide binding]; other site
563174005362	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
563174005363	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
563174005364	TAP-like protein; Region: Abhydrolase_4; pfam08386
563174005365	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
563174005366	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
563174005367	dimer interface [polypeptide binding]; other site
563174005368	tetramer interface [polypeptide binding]; other site
563174005369	PYR/PP interface [polypeptide binding]; other site
563174005370	TPP binding site [chemical binding]; other site
563174005371	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
563174005372	TPP-binding site; other site
563174005373	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
563174005374	chorismate binding enzyme; Region: Chorismate_bind; cl10555
563174005375	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
563174005376	UbiA prenyltransferase family; Region: UbiA; pfam01040
563174005377	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
563174005378	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
563174005379	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
563174005380	FAD binding site [chemical binding]; other site
563174005381	cystathionine beta-lyase; Provisional; Region: PRK08064
563174005382	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
563174005383	homodimer interface [polypeptide binding]; other site
563174005384	substrate-cofactor binding pocket; other site
563174005385	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174005386	catalytic residue [active]
563174005387	cystathionine gamma-synthase; Reviewed; Region: PRK08247
563174005388	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
563174005389	homodimer interface [polypeptide binding]; other site
563174005390	substrate-cofactor binding pocket; other site
563174005391	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174005392	catalytic residue [active]
563174005393	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
563174005394	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
563174005395	THF binding site; other site
563174005396	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
563174005397	substrate binding site [chemical binding]; other site
563174005398	THF binding site; other site
563174005399	zinc-binding site [ion binding]; other site
563174005400	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174005401	Major Facilitator Superfamily; Region: MFS_1; pfam07690
563174005402	putative substrate translocation pore; other site
563174005403	ferric uptake regulator; Provisional; Region: fur; PRK09462
563174005404	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
563174005405	metal binding site 2 [ion binding]; metal-binding site
563174005406	putative DNA binding helix; other site
563174005407	metal binding site 1 [ion binding]; metal-binding site
563174005408	dimer interface [polypeptide binding]; other site
563174005409	structural Zn2+ binding site [ion binding]; other site
563174005410	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
563174005411	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
563174005412	NAD binding site [chemical binding]; other site
563174005413	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
563174005414	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
563174005415	inhibitor-cofactor binding pocket; inhibition site
563174005416	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174005417	catalytic residue [active]
563174005418	Predicted membrane protein [Function unknown]; Region: COG4129
563174005419	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
563174005420	hypothetical protein; Provisional; Region: PRK13662
563174005421	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
563174005422	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
563174005423	putative NAD(P) binding site [chemical binding]; other site
563174005424	active site
563174005425	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
563174005426	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
563174005427	minor groove reading motif; other site
563174005428	helix-hairpin-helix signature motif; other site
563174005429	substrate binding pocket [chemical binding]; other site
563174005430	active site
563174005431	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
563174005432	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
563174005433	DNA binding and oxoG recognition site [nucleotide binding]
563174005434	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
563174005435	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
563174005436	trimer interface [polypeptide binding]; other site
563174005437	active site
563174005438	WVELL protein; Region: WVELL; pfam14043
563174005439	recombination regulator RecX; Provisional; Region: recX; PRK14135
563174005440	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
563174005441	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
563174005442	NAD(P) binding site [chemical binding]; other site
563174005443	active site
563174005444	Predicted integral membrane protein [Function unknown]; Region: COG0392
563174005445	Uncharacterized conserved protein [Function unknown]; Region: COG2898
563174005446	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
563174005447	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
563174005448	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
563174005449	Cation efflux family; Region: Cation_efflux; pfam01545
563174005450	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
563174005451	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
563174005452	PAS fold; Region: PAS_4; pfam08448
563174005453	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
563174005454	putative active site [active]
563174005455	heme pocket [chemical binding]; other site
563174005456	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
563174005457	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
563174005458	dimer interface [polypeptide binding]; other site
563174005459	putative CheW interface [polypeptide binding]; other site
563174005460	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
563174005461	FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364
563174005462	dimer interface [polypeptide binding]; other site
563174005463	active site
563174005464	Mn binding site [ion binding]; other site
563174005465	TRAM domain; Region: TRAM; cl01282
563174005466	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
563174005467	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174005468	S-adenosylmethionine binding site [chemical binding]; other site
563174005469	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
563174005470	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
563174005471	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
563174005472	Substrate-binding site [chemical binding]; other site
563174005473	Substrate specificity [chemical binding]; other site
563174005474	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
563174005475	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840
563174005476	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
563174005477	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
563174005478	active site
563174005479	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
563174005480	flavodoxin, short chain; Region: flav_short; TIGR01753
563174005481	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
563174005482	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
563174005483	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174005484	Major Facilitator Superfamily; Region: MFS_1; pfam07690
563174005485	putative substrate translocation pore; other site
563174005486	rod-share determining protein MreBH; Provisional; Region: PRK13929
563174005487	MreB and similar proteins; Region: MreB_like; cd10225
563174005488	nucleotide binding site [chemical binding]; other site
563174005489	Mg binding site [ion binding]; other site
563174005490	putative protofilament interaction site [polypeptide binding]; other site
563174005491	RodZ interaction site [polypeptide binding]; other site
563174005492	Methyltransferase domain; Region: Methyltransf_31; pfam13847
563174005493	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174005494	S-adenosylmethionine binding site [chemical binding]; other site
563174005495	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
563174005496	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
563174005497	Uncharacterized conserved protein [Function unknown]; Region: COG4748
563174005498	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
563174005499	Uncharacterized conserved protein [Function unknown]; Region: COG3589
563174005500	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
563174005501	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
563174005502	methionine cluster; other site
563174005503	active site
563174005504	phosphorylation site [posttranslational modification]
563174005505	metal binding site [ion binding]; metal-binding site
563174005506	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
563174005507	active site
563174005508	P-loop; other site
563174005509	phosphorylation site [posttranslational modification]
563174005510	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
563174005511	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
563174005512	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174005513	Walker A motif; other site
563174005514	ATP binding site [chemical binding]; other site
563174005515	Walker B motif; other site
563174005516	arginine finger; other site
563174005517	Transcriptional antiterminator [Transcription]; Region: COG3933
563174005518	PRD domain; Region: PRD; pfam00874
563174005519	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
563174005520	active pocket/dimerization site; other site
563174005521	active site
563174005522	phosphorylation site [posttranslational modification]
563174005523	PRD domain; Region: PRD; pfam00874
563174005524	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
563174005525	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
563174005526	ATP binding site [chemical binding]; other site
563174005527	putative Mg++ binding site [ion binding]; other site
563174005528	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
563174005529	nucleotide binding region [chemical binding]; other site
563174005530	ATP-binding site [chemical binding]; other site
563174005531	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
563174005532	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
563174005533	Transcriptional regulators [Transcription]; Region: PurR; COG1609
563174005534	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
563174005535	DNA binding site [nucleotide binding]
563174005536	domain linker motif; other site
563174005537	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
563174005538	dimerization interface [polypeptide binding]; other site
563174005539	ligand binding site [chemical binding]; other site
563174005540	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
563174005541	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
563174005542	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
563174005543	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
563174005544	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
563174005545	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
563174005546	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174005547	dimer interface [polypeptide binding]; other site
563174005548	conserved gate region; other site
563174005549	putative PBP binding loops; other site
563174005550	ABC-ATPase subunit interface; other site
563174005551	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
563174005552	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174005553	dimer interface [polypeptide binding]; other site
563174005554	conserved gate region; other site
563174005555	putative PBP binding loops; other site
563174005556	ABC-ATPase subunit interface; other site
563174005557	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
563174005558	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
563174005559	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
563174005560	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
563174005561	active site
563174005562	dimer interface [polypeptide binding]; other site
563174005563	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
563174005564	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
563174005565	active site
563174005566	FMN binding site [chemical binding]; other site
563174005567	substrate binding site [chemical binding]; other site
563174005568	3Fe-4S cluster binding site [ion binding]; other site
563174005569	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
563174005570	domain interface; other site
563174005571	Transcriptional regulator [Transcription]; Region: LysR; COG0583
563174005572	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
563174005573	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
563174005574	putative dimerization interface [polypeptide binding]; other site
563174005575	Predicted acetyltransferase [General function prediction only]; Region: COG3153
563174005576	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
563174005577	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
563174005578	putative active site [active]
563174005579	metal binding site [ion binding]; metal-binding site
563174005580	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
563174005581	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
563174005582	substrate binding pocket [chemical binding]; other site
563174005583	membrane-bound complex binding site; other site
563174005584	hinge residues; other site
563174005585	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
563174005586	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174005587	Walker A/P-loop; other site
563174005588	ATP binding site [chemical binding]; other site
563174005589	Q-loop/lid; other site
563174005590	ABC transporter signature motif; other site
563174005591	Walker B; other site
563174005592	D-loop; other site
563174005593	H-loop/switch region; other site
563174005594	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174005595	dimer interface [polypeptide binding]; other site
563174005596	conserved gate region; other site
563174005597	putative PBP binding loops; other site
563174005598	ABC-ATPase subunit interface; other site
563174005599	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
563174005600	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
563174005601	dimer interface [polypeptide binding]; other site
563174005602	phosphorylation site [posttranslational modification]
563174005603	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174005604	ATP binding site [chemical binding]; other site
563174005605	Mg2+ binding site [ion binding]; other site
563174005606	G-X-G motif; other site
563174005607	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
563174005608	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
563174005609	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
563174005610	active site
563174005611	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
563174005612	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
563174005613	putative NAD(P) binding site [chemical binding]; other site
563174005614	active site
563174005615	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
563174005616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174005617	active site
563174005618	phosphorylation site [posttranslational modification]
563174005619	intermolecular recognition site; other site
563174005620	dimerization interface [polypeptide binding]; other site
563174005621	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
563174005622	DNA binding site [nucleotide binding]
563174005623	FtsX-like permease family; Region: FtsX; pfam02687
563174005624	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
563174005625	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
563174005626	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
563174005627	Walker A/P-loop; other site
563174005628	ATP binding site [chemical binding]; other site
563174005629	Q-loop/lid; other site
563174005630	ABC transporter signature motif; other site
563174005631	Walker B; other site
563174005632	D-loop; other site
563174005633	H-loop/switch region; other site
563174005634	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
563174005635	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
563174005636	ADP binding site [chemical binding]; other site
563174005637	magnesium binding site [ion binding]; other site
563174005638	putative shikimate binding site; other site
563174005639	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884
563174005640	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
563174005641	TRAM domain; Region: TRAM; pfam01938
563174005642	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174005643	S-adenosylmethionine binding site [chemical binding]; other site
563174005644	putative lipid kinase; Reviewed; Region: PRK13337
563174005645	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
563174005646	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
563174005647	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
563174005648	GatB domain; Region: GatB_Yqey; pfam02637
563174005649	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
563174005650	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
563174005651	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
563174005652	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
563174005653	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
563174005654	putative dimer interface [polypeptide binding]; other site
563174005655	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
563174005656	putative dimer interface [polypeptide binding]; other site
563174005657	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
563174005658	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
563174005659	nucleotide binding pocket [chemical binding]; other site
563174005660	K-X-D-G motif; other site
563174005661	catalytic site [active]
563174005662	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
563174005663	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
563174005664	Dimer interface [polypeptide binding]; other site
563174005665	BRCT sequence motif; other site
563174005666	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
563174005667	Part of AAA domain; Region: AAA_19; pfam13245
563174005668	Family description; Region: UvrD_C_2; pfam13538
563174005669	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
563174005670	PcrB family; Region: PcrB; pfam01884
563174005671	substrate binding site [chemical binding]; other site
563174005672	putative active site [active]
563174005673	dimer interface [polypeptide binding]; other site
563174005674	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
563174005675	Na2 binding site [ion binding]; other site
563174005676	putative substrate binding site 1 [chemical binding]; other site
563174005677	Na binding site 1 [ion binding]; other site
563174005678	putative substrate binding site 2 [chemical binding]; other site
563174005679	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
563174005680	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
563174005681	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
563174005682	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
563174005683	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
563174005684	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
563174005685	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
563174005686	purine monophosphate binding site [chemical binding]; other site
563174005687	dimer interface [polypeptide binding]; other site
563174005688	putative catalytic residues [active]
563174005689	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
563174005690	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
563174005691	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
563174005692	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
563174005693	active site
563174005694	substrate binding site [chemical binding]; other site
563174005695	cosubstrate binding site; other site
563174005696	catalytic site [active]
563174005697	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
563174005698	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
563174005699	dimerization interface [polypeptide binding]; other site
563174005700	putative ATP binding site [chemical binding]; other site
563174005701	amidophosphoribosyltransferase; Provisional; Region: PRK06781
563174005702	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
563174005703	active site
563174005704	tetramer interface [polypeptide binding]; other site
563174005705	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
563174005706	active site
563174005707	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
563174005708	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
563174005709	dimerization interface [polypeptide binding]; other site
563174005710	ATP binding site [chemical binding]; other site
563174005711	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
563174005712	dimerization interface [polypeptide binding]; other site
563174005713	ATP binding site [chemical binding]; other site
563174005714	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
563174005715	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
563174005716	putative active site [active]
563174005717	catalytic triad [active]
563174005718	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
563174005719	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
563174005720	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
563174005721	ATP binding site [chemical binding]; other site
563174005722	active site
563174005723	substrate binding site [chemical binding]; other site
563174005724	adenylosuccinate lyase; Provisional; Region: PRK07492
563174005725	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
563174005726	tetramer interface [polypeptide binding]; other site
563174005727	active site
563174005728	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
563174005729	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
563174005730	NAD binding site [chemical binding]; other site
563174005731	ATP-grasp domain; Region: ATP-grasp; pfam02222
563174005732	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
563174005733	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
563174005734	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
563174005735	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
563174005736	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
563174005737	Zn2+ binding site [ion binding]; other site
563174005738	Mg2+ binding site [ion binding]; other site
563174005739	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
563174005740	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
563174005741	Walker A/P-loop; other site
563174005742	ATP binding site [chemical binding]; other site
563174005743	Q-loop/lid; other site
563174005744	ABC transporter signature motif; other site
563174005745	Walker B; other site
563174005746	D-loop; other site
563174005747	H-loop/switch region; other site
563174005748	peptidase T; Region: peptidase-T; TIGR01882
563174005749	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
563174005750	metal binding site [ion binding]; metal-binding site
563174005751	dimer interface [polypeptide binding]; other site
563174005752	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
563174005753	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
563174005754	active site
563174005755	putative catalytic site [active]
563174005756	DNA binding site [nucleotide binding]
563174005757	putative phosphate binding site [ion binding]; other site
563174005758	metal binding site A [ion binding]; metal-binding site
563174005759	AP binding site [nucleotide binding]; other site
563174005760	metal binding site B [ion binding]; metal-binding site
563174005761	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
563174005762	23S rRNA binding site [nucleotide binding]; other site
563174005763	L21 binding site [polypeptide binding]; other site
563174005764	L13 binding site [polypeptide binding]; other site
563174005765	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
563174005766	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
563174005767	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
563174005768	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
563174005769	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
563174005770	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
563174005771	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
563174005772	active site
563174005773	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
563174005774	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
563174005775	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
563174005776	DNA binding residues [nucleotide binding]
563174005777	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
563174005778	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
563174005779	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
563174005780	Putative heavy-metal-binding; Region: YbjQ_1; pfam01906
563174005781	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
563174005782	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
563174005783	RimM N-terminal domain; Region: RimM; pfam01782
563174005784	PRC-barrel domain; Region: PRC; pfam05239
563174005785	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
563174005786	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
563174005787	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
563174005788	catalytic triad [active]
563174005789	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
563174005790	KH domain; Region: KH_4; pfam13083
563174005791	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
563174005792	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
563174005793	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
563174005794	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
563174005795	signal recognition particle protein; Provisional; Region: PRK10867
563174005796	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
563174005797	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
563174005798	P loop; other site
563174005799	GTP binding site [chemical binding]; other site
563174005800	Signal peptide binding domain; Region: SRP_SPB; pfam02978
563174005801	putative DNA-binding protein; Validated; Region: PRK00118
563174005802	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
563174005803	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
563174005804	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
563174005805	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
563174005806	P loop; other site
563174005807	GTP binding site [chemical binding]; other site
563174005808	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
563174005809	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
563174005810	Walker A/P-loop; other site
563174005811	ATP binding site [chemical binding]; other site
563174005812	Q-loop/lid; other site
563174005813	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
563174005814	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
563174005815	linker region; other site
563174005816	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
563174005817	ABC transporter signature motif; other site
563174005818	Walker B; other site
563174005819	D-loop; other site
563174005820	H-loop/switch region; other site
563174005821	ribonuclease III; Reviewed; Region: rnc; PRK00102
563174005822	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
563174005823	dimerization interface [polypeptide binding]; other site
563174005824	active site
563174005825	metal binding site [ion binding]; metal-binding site
563174005826	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
563174005827	dsRNA binding site [nucleotide binding]; other site
563174005828	acyl carrier protein; Provisional; Region: acpP; PRK00982
563174005829	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
563174005830	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
563174005831	NAD(P) binding site [chemical binding]; other site
563174005832	homotetramer interface [polypeptide binding]; other site
563174005833	homodimer interface [polypeptide binding]; other site
563174005834	active site
563174005835	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
563174005836	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
563174005837	putative phosphate acyltransferase; Provisional; Region: PRK05331
563174005838	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
563174005839	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
563174005840	active site 2 [active]
563174005841	active site 1 [active]
563174005842	Y-family of DNA polymerases; Region: PolY; cl12025
563174005843	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
563174005844	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
563174005845	generic binding surface II; other site
563174005846	ssDNA binding site; other site
563174005847	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
563174005848	ATP binding site [chemical binding]; other site
563174005849	putative Mg++ binding site [ion binding]; other site
563174005850	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
563174005851	nucleotide binding region [chemical binding]; other site
563174005852	ATP-binding site [chemical binding]; other site
563174005853	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
563174005854	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
563174005855	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
563174005856	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
563174005857	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
563174005858	putative L-serine binding site [chemical binding]; other site
563174005859	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
563174005860	DAK2 domain; Region: Dak2; pfam02734
563174005861	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
563174005862	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
563174005863	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
563174005864	Thiamine pyrophosphokinase; Region: TPK; cd07995
563174005865	active site
563174005866	dimerization interface [polypeptide binding]; other site
563174005867	thiamine binding site [chemical binding]; other site
563174005868	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
563174005869	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
563174005870	substrate binding site [chemical binding]; other site
563174005871	hexamer interface [polypeptide binding]; other site
563174005872	metal binding site [ion binding]; metal-binding site
563174005873	GTPase RsgA; Reviewed; Region: PRK00098
563174005874	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
563174005875	RNA binding site [nucleotide binding]; other site
563174005876	homodimer interface [polypeptide binding]; other site
563174005877	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
563174005878	GTPase/Zn-binding domain interface [polypeptide binding]; other site
563174005879	GTP/Mg2+ binding site [chemical binding]; other site
563174005880	G4 box; other site
563174005881	G1 box; other site
563174005882	Switch I region; other site
563174005883	G2 box; other site
563174005884	G3 box; other site
563174005885	Switch II region; other site
563174005886	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
563174005887	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
563174005888	active site
563174005889	ATP binding site [chemical binding]; other site
563174005890	substrate binding site [chemical binding]; other site
563174005891	activation loop (A-loop); other site
563174005892	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
563174005893	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
563174005894	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
563174005895	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
563174005896	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
563174005897	Protein phosphatase 2C; Region: PP2C; pfam00481
563174005898	active site
563174005899	16S rRNA methyltransferase B; Provisional; Region: PRK14902
563174005900	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
563174005901	putative RNA binding site [nucleotide binding]; other site
563174005902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174005903	S-adenosylmethionine binding site [chemical binding]; other site
563174005904	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
563174005905	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
563174005906	putative active site [active]
563174005907	substrate binding site [chemical binding]; other site
563174005908	putative cosubstrate binding site; other site
563174005909	catalytic site [active]
563174005910	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
563174005911	substrate binding site [chemical binding]; other site
563174005912	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
563174005913	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
563174005914	ATP binding site [chemical binding]; other site
563174005915	putative Mg++ binding site [ion binding]; other site
563174005916	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
563174005917	ATP-binding site [chemical binding]; other site
563174005918	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
563174005919	Flavoprotein; Region: Flavoprotein; pfam02441
563174005920	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
563174005921	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
563174005922	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
563174005923	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
563174005924	catalytic site [active]
563174005925	G-X2-G-X-G-K; other site
563174005926	Uncharacterized stress-induced protein [Function unknown]; Region: COG1561
563174005927	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
563174005928	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
563174005929	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
563174005930	Domain of unknown function (DUF814); Region: DUF814; pfam05670
563174005931	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
563174005932	putative NAD(P) binding site [chemical binding]; other site
563174005933	homodimer interface [polypeptide binding]; other site
563174005934	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
563174005935	active site
563174005936	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
563174005937	active site
563174005938	dimer interface [polypeptide binding]; other site
563174005939	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
563174005940	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
563174005941	heterodimer interface [polypeptide binding]; other site
563174005942	active site
563174005943	FMN binding site [chemical binding]; other site
563174005944	homodimer interface [polypeptide binding]; other site
563174005945	substrate binding site [chemical binding]; other site
563174005946	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
563174005947	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
563174005948	FAD binding pocket [chemical binding]; other site
563174005949	FAD binding motif [chemical binding]; other site
563174005950	phosphate binding motif [ion binding]; other site
563174005951	beta-alpha-beta structure motif; other site
563174005952	NAD binding pocket [chemical binding]; other site
563174005953	Iron coordination center [ion binding]; other site
563174005954	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
563174005955	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
563174005956	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
563174005957	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
563174005958	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
563174005959	ATP-grasp domain; Region: ATP-grasp_4; cl17255
563174005960	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
563174005961	IMP binding site; other site
563174005962	dimer interface [polypeptide binding]; other site
563174005963	interdomain contacts; other site
563174005964	partial ornithine binding site; other site
563174005965	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
563174005966	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
563174005967	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
563174005968	catalytic site [active]
563174005969	subunit interface [polypeptide binding]; other site
563174005970	dihydroorotase; Validated; Region: pyrC; PRK09357
563174005971	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
563174005972	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
563174005973	active site
563174005974	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
563174005975	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
563174005976	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
563174005977	uracil transporter; Provisional; Region: PRK10720
563174005978	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
563174005979	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
563174005980	active site
563174005981	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
563174005982	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
563174005983	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
563174005984	RNA binding surface [nucleotide binding]; other site
563174005985	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
563174005986	active site
563174005987	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
563174005988	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
563174005989	Sulfate transporter family; Region: Sulfate_transp; pfam00916
563174005990	multidrug efflux protein; Reviewed; Region: PRK01766
563174005991	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
563174005992	cation binding site [ion binding]; other site
563174005993	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
563174005994	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
563174005995	metal binding site [ion binding]; metal-binding site
563174005996	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
563174005997	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
563174005998	ABC-ATPase subunit  interface; other site
563174005999	dimer interface [polypeptide binding]; other site
563174006000	putative PBP binding regions; other site
563174006001	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
563174006002	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
563174006003	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
563174006004	MarR family; Region: MarR; pfam01047
563174006005	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
563174006006	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
563174006007	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
563174006008	protein binding site [polypeptide binding]; other site
563174006009	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
563174006010	Catalytic dyad [active]
563174006011	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
563174006012	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
563174006013	metal-binding site [ion binding]
563174006014	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
563174006015	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
563174006016	metal-binding site [ion binding]
563174006017	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
563174006018	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174006019	motif II; other site
563174006020	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
563174006021	putative homodimer interface [polypeptide binding]; other site
563174006022	putative homotetramer interface [polypeptide binding]; other site
563174006023	putative allosteric switch controlling residues; other site
563174006024	putative metal binding site [ion binding]; other site
563174006025	putative homodimer-homodimer interface [polypeptide binding]; other site
563174006026	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
563174006027	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
563174006028	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
563174006029	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
563174006030	hypothetical protein; Provisional; Region: PRK13672
563174006031	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
563174006032	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
563174006033	methionine sulfoxide reductase B; Provisional; Region: PRK00222
563174006034	SelR domain; Region: SelR; pfam01641
563174006035	methionine sulfoxide reductase A; Provisional; Region: PRK14054
563174006036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698
563174006037	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
563174006038	active site
563174006039	catalytic triad [active]
563174006040	oxyanion hole [active]
563174006041	EDD domain protein, DegV family; Region: DegV; TIGR00762
563174006042	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
563174006043	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
563174006044	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
563174006045	HTH domain; Region: HTH_11; pfam08279
563174006046	FOG: CBS domain [General function prediction only]; Region: COG0517
563174006047	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
563174006048	PEP synthetase regulatory protein; Provisional; Region: PRK05339
563174006049	pyruvate phosphate dikinase; Provisional; Region: PRK09279
563174006050	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
563174006051	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
563174006052	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
563174006053	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
563174006054	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
563174006055	Predicted membrane protein [Function unknown]; Region: COG4129
563174006056	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
563174006057	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
563174006058	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
563174006059	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
563174006060	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
563174006061	active site
563174006062	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
563174006063	substrate binding site [chemical binding]; other site
563174006064	metal binding site [ion binding]; metal-binding site
563174006065	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
563174006066	Methyltransferase domain; Region: Methyltransf_11; pfam08241
563174006067	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
563174006068	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
563174006069	folate binding site [chemical binding]; other site
563174006070	NADP+ binding site [chemical binding]; other site
563174006071	thymidylate synthase; Region: thym_sym; TIGR03284
563174006072	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
563174006073	dimerization interface [polypeptide binding]; other site
563174006074	active site
563174006075	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
563174006076	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
563174006077	Walker A/P-loop; other site
563174006078	ATP binding site [chemical binding]; other site
563174006079	Q-loop/lid; other site
563174006080	ABC transporter signature motif; other site
563174006081	Walker B; other site
563174006082	D-loop; other site
563174006083	H-loop/switch region; other site
563174006084	ABC transporter; Region: ABC_tran_2; pfam12848
563174006085	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
563174006086	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
563174006087	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
563174006088	Potassium binding sites [ion binding]; other site
563174006089	Cesium cation binding sites [ion binding]; other site
563174006090	manganese transport transcriptional regulator; Provisional; Region: PRK03902
563174006091	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
563174006092	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
563174006093	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
563174006094	DNA-binding site [nucleotide binding]; DNA binding site
563174006095	RNA-binding motif; other site
563174006096	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
563174006097	RNA/DNA hybrid binding site [nucleotide binding]; other site
563174006098	active site
563174006099	5'-3' exonuclease; Region: 53EXOc; smart00475
563174006100	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
563174006101	active site
563174006102	metal binding site 1 [ion binding]; metal-binding site
563174006103	putative 5' ssDNA interaction site; other site
563174006104	metal binding site 3; metal-binding site
563174006105	metal binding site 2 [ion binding]; metal-binding site
563174006106	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
563174006107	putative DNA binding site [nucleotide binding]; other site
563174006108	putative metal binding site [ion binding]; other site
563174006109	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
563174006110	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
563174006111	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
563174006112	putative active site [active]
563174006113	xanthine permease; Region: pbuX; TIGR03173
563174006114	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
563174006115	active site
563174006116	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
563174006117	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
563174006118	active site
563174006119	Zn binding site [ion binding]; other site
563174006120	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
563174006121	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
563174006122	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
563174006123	cell division protein GpsB; Provisional; Region: PRK14127
563174006124	DivIVA domain; Region: DivI1A_domain; TIGR03544
563174006125	Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884
563174006126	hypothetical protein; Provisional; Region: PRK13660
563174006127	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
563174006128	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
563174006129	Transglycosylase; Region: Transgly; pfam00912
563174006130	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
563174006131	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
563174006132	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
563174006133	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
563174006134	minor groove reading motif; other site
563174006135	helix-hairpin-helix signature motif; other site
563174006136	substrate binding pocket [chemical binding]; other site
563174006137	active site
563174006138	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
563174006139	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
563174006140	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
563174006141	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
563174006142	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
563174006143	putative dimer interface [polypeptide binding]; other site
563174006144	putative anticodon binding site; other site
563174006145	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
563174006146	homodimer interface [polypeptide binding]; other site
563174006147	motif 1; other site
563174006148	motif 2; other site
563174006149	active site
563174006150	motif 3; other site
563174006151	aspartate aminotransferase; Provisional; Region: PRK05764
563174006152	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
563174006153	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174006154	homodimer interface [polypeptide binding]; other site
563174006155	catalytic residue [active]
563174006156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
563174006157	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
563174006158	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
563174006159	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
563174006160	active site
563174006161	catalytic site [active]
563174006162	substrate binding site [chemical binding]; other site
563174006163	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
563174006164	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
563174006165	putative Mg++ binding site [ion binding]; other site
563174006166	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
563174006167	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
563174006168	tetramerization interface [polypeptide binding]; other site
563174006169	active site
563174006170	pantoate--beta-alanine ligase; Region: panC; TIGR00018
563174006171	Pantoate-beta-alanine ligase; Region: PanC; cd00560
563174006172	active site
563174006173	ATP-binding site [chemical binding]; other site
563174006174	pantoate-binding site; other site
563174006175	HXXH motif; other site
563174006176	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
563174006177	active site
563174006178	oligomerization interface [polypeptide binding]; other site
563174006179	metal binding site [ion binding]; metal-binding site
563174006180	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
563174006181	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
563174006182	catalytic residues [active]
563174006183	Biotin operon repressor [Transcription]; Region: BirA; COG1654
563174006184	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
563174006185	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
563174006186	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
563174006187	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
563174006188	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
563174006189	active site
563174006190	NTP binding site [chemical binding]; other site
563174006191	metal binding triad [ion binding]; metal-binding site
563174006192	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
563174006193	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
563174006194	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
563174006195	active site
563174006196	dimer interfaces [polypeptide binding]; other site
563174006197	catalytic residues [active]
563174006198	dihydrodipicolinate reductase; Provisional; Region: PRK00048
563174006199	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
563174006200	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
563174006201	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
563174006202	homodimer interface [polypeptide binding]; other site
563174006203	metal binding site [ion binding]; metal-binding site
563174006204	Uncharacterized conserved protein [Function unknown]; Region: COG1284
563174006205	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
563174006206	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
563174006207	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
563174006208	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
563174006209	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
563174006210	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
563174006211	metal binding site [ion binding]; metal-binding site
563174006212	active site
563174006213	I-site; other site
563174006214	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
563174006215	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
563174006216	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
563174006217	metal binding site [ion binding]; metal-binding site
563174006218	active site
563174006219	I-site; other site
563174006220	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
563174006221	malate dehydrogenase; Provisional; Region: PRK13529
563174006222	Malic enzyme, N-terminal domain; Region: malic; pfam00390
563174006223	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
563174006224	NAD(P) binding pocket [chemical binding]; other site
563174006225	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
563174006226	Beta-lactamase; Region: Beta-lactamase; pfam00144
563174006227	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
563174006228	Pyruvate formate lyase 1; Region: PFL1; cd01678
563174006229	coenzyme A binding site [chemical binding]; other site
563174006230	active site
563174006231	catalytic residues [active]
563174006232	glycine loop; other site
563174006233	HI0933-like protein; Region: HI0933_like; pfam03486
563174006234	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
563174006235	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
563174006236	Predicted membrane protein [Function unknown]; Region: COG4347
563174006237	hypothetical protein; Provisional; Region: PRK03636
563174006238	UPF0302 domain; Region: UPF0302; pfam08864
563174006239	IDEAL domain; Region: IDEAL; pfam08858
563174006240	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
563174006241	binding surface
563174006242	TPR motif; other site
563174006243	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
563174006244	binding surface
563174006245	Tetratricopeptide repeat; Region: TPR_16; pfam13432
563174006246	TPR motif; other site
563174006247	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
563174006248	binding surface
563174006249	TPR motif; other site
563174006250	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
563174006251	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
563174006252	hinge; other site
563174006253	active site
563174006254	prephenate dehydrogenase; Validated; Region: PRK06545
563174006255	prephenate dehydrogenase; Validated; Region: PRK08507
563174006256	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
563174006257	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
563174006258	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
563174006259	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174006260	homodimer interface [polypeptide binding]; other site
563174006261	catalytic residue [active]
563174006262	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
563174006263	homotrimer interaction site [polypeptide binding]; other site
563174006264	active site
563174006265	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
563174006266	active site
563174006267	dimer interface [polypeptide binding]; other site
563174006268	metal binding site [ion binding]; metal-binding site
563174006269	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
563174006270	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
563174006271	Tetramer interface [polypeptide binding]; other site
563174006272	active site
563174006273	FMN-binding site [chemical binding]; other site
563174006274	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
563174006275	active site
563174006276	multimer interface [polypeptide binding]; other site
563174006277	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
563174006278	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
563174006279	substrate binding pocket [chemical binding]; other site
563174006280	chain length determination region; other site
563174006281	substrate-Mg2+ binding site; other site
563174006282	catalytic residues [active]
563174006283	aspartate-rich region 1; other site
563174006284	active site lid residues [active]
563174006285	aspartate-rich region 2; other site
563174006286	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
563174006287	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174006288	S-adenosylmethionine binding site [chemical binding]; other site
563174006289	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
563174006290	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
563174006291	homodecamer interface [polypeptide binding]; other site
563174006292	GTP cyclohydrolase I; Provisional; Region: PLN03044
563174006293	active site
563174006294	putative catalytic site residues [active]
563174006295	zinc binding site [ion binding]; other site
563174006296	GTP-CH-I/GFRP interaction surface; other site
563174006297	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
563174006298	IHF dimer interface [polypeptide binding]; other site
563174006299	IHF - DNA interface [nucleotide binding]; other site
563174006300	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
563174006301	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
563174006302	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
563174006303	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
563174006304	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
563174006305	GTP-binding protein Der; Reviewed; Region: PRK00093
563174006306	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
563174006307	G1 box; other site
563174006308	GTP/Mg2+ binding site [chemical binding]; other site
563174006309	Switch I region; other site
563174006310	G2 box; other site
563174006311	Switch II region; other site
563174006312	G3 box; other site
563174006313	G4 box; other site
563174006314	G5 box; other site
563174006315	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
563174006316	G1 box; other site
563174006317	GTP/Mg2+ binding site [chemical binding]; other site
563174006318	Switch I region; other site
563174006319	G2 box; other site
563174006320	G3 box; other site
563174006321	Switch II region; other site
563174006322	G4 box; other site
563174006323	G5 box; other site
563174006324	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
563174006325	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
563174006326	RNA binding site [nucleotide binding]; other site
563174006327	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
563174006328	RNA binding site [nucleotide binding]; other site
563174006329	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
563174006330	RNA binding site [nucleotide binding]; other site
563174006331	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
563174006332	RNA binding site [nucleotide binding]; other site
563174006333	cytidylate kinase; Provisional; Region: cmk; PRK00023
563174006334	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
563174006335	CMP-binding site; other site
563174006336	The sites determining sugar specificity; other site
563174006337	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
563174006338	active site
563174006339	homotetramer interface [polypeptide binding]; other site
563174006340	homodimer interface [polypeptide binding]; other site
563174006341	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
563174006342	DEAD-like helicases superfamily; Region: DEXDc; smart00487
563174006343	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
563174006344	ATP binding site [chemical binding]; other site
563174006345	putative Mg++ binding site [ion binding]; other site
563174006346	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
563174006347	nucleotide binding region [chemical binding]; other site
563174006348	ATP-binding site [chemical binding]; other site
563174006349	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
563174006350	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
563174006351	Predicted membrane protein [Function unknown]; Region: COG3601
563174006352	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
563174006353	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
563174006354	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
563174006355	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
563174006356	dimerization interface [polypeptide binding]; other site
563174006357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
563174006358	dimer interface [polypeptide binding]; other site
563174006359	phosphorylation site [posttranslational modification]
563174006360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174006361	ATP binding site [chemical binding]; other site
563174006362	Mg2+ binding site [ion binding]; other site
563174006363	G-X-G motif; other site
563174006364	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
563174006365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174006366	active site
563174006367	phosphorylation site [posttranslational modification]
563174006368	intermolecular recognition site; other site
563174006369	dimerization interface [polypeptide binding]; other site
563174006370	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
563174006371	DNA binding site [nucleotide binding]
563174006372	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
563174006373	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
563174006374	RNA binding surface [nucleotide binding]; other site
563174006375	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
563174006376	active site
563174006377	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
563174006378	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
563174006379	diaminopimelate decarboxylase; Region: lysA; TIGR01048
563174006380	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
563174006381	active site
563174006382	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
563174006383	substrate binding site [chemical binding]; other site
563174006384	catalytic residues [active]
563174006385	dimer interface [polypeptide binding]; other site
563174006386	purine nucleoside phosphorylase; Provisional; Region: PRK08202
563174006387	phosphopentomutase; Provisional; Region: PRK05362
563174006388	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
563174006389	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
563174006390	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
563174006391	active site
563174006392	Int/Topo IB signature motif; other site
563174006393	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
563174006394	metal binding site 2 [ion binding]; metal-binding site
563174006395	putative DNA binding helix; other site
563174006396	metal binding site 1 [ion binding]; metal-binding site
563174006397	dimer interface [polypeptide binding]; other site
563174006398	structural Zn2+ binding site [ion binding]; other site
563174006399	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
563174006400	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
563174006401	ABC-ATPase subunit  interface; other site
563174006402	dimer interface [polypeptide binding]; other site
563174006403	putative PBP binding regions; other site
563174006404	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
563174006405	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
563174006406	ABC-ATPase subunit  interface; other site
563174006407	dimer interface [polypeptide binding]; other site
563174006408	putative PBP binding regions; other site
563174006409	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
563174006410	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
563174006411	putative ligand binding residues [chemical binding]; other site
563174006412	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
563174006413	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
563174006414	Walker A/P-loop; other site
563174006415	ATP binding site [chemical binding]; other site
563174006416	Q-loop/lid; other site
563174006417	ABC transporter signature motif; other site
563174006418	Walker B; other site
563174006419	D-loop; other site
563174006420	H-loop/switch region; other site
563174006421	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
563174006422	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
563174006423	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
563174006424	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
563174006425	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
563174006426	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
563174006427	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
563174006428	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
563174006429	Walker A/P-loop; other site
563174006430	ATP binding site [chemical binding]; other site
563174006431	Q-loop/lid; other site
563174006432	ABC transporter signature motif; other site
563174006433	Walker B; other site
563174006434	D-loop; other site
563174006435	H-loop/switch region; other site
563174006436	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
563174006437	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
563174006438	dimer interface [polypeptide binding]; other site
563174006439	ADP-ribose binding site [chemical binding]; other site
563174006440	active site
563174006441	nudix motif; other site
563174006442	metal binding site [ion binding]; metal-binding site
563174006443	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
563174006444	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
563174006445	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
563174006446	active site
563174006447	DNA polymerase IV; Validated; Region: PRK02406
563174006448	DNA binding site [nucleotide binding]
563174006449	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
563174006450	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
563174006451	NAD(P) binding site [chemical binding]; other site
563174006452	active site
563174006453	ribonuclease Z; Region: RNase_Z; TIGR02651
563174006454	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
563174006455	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
563174006456	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
563174006457	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
563174006458	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
563174006459	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174006460	Coenzyme A binding pocket [chemical binding]; other site
563174006461	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
563174006462	6-phosphogluconate dehydratase; Region: edd; TIGR01196
563174006463	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
563174006464	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
563174006465	PYR/PP interface [polypeptide binding]; other site
563174006466	dimer interface [polypeptide binding]; other site
563174006467	TPP binding site [chemical binding]; other site
563174006468	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
563174006469	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
563174006470	TPP-binding site [chemical binding]; other site
563174006471	dimer interface [polypeptide binding]; other site
563174006472	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
563174006473	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
563174006474	putative valine binding site [chemical binding]; other site
563174006475	dimer interface [polypeptide binding]; other site
563174006476	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
563174006477	ketol-acid reductoisomerase; Provisional; Region: PRK05479
563174006478	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
563174006479	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
563174006480	2-isopropylmalate synthase; Validated; Region: PRK00915
563174006481	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
563174006482	active site
563174006483	catalytic residues [active]
563174006484	metal binding site [ion binding]; metal-binding site
563174006485	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
563174006486	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
563174006487	tartrate dehydrogenase; Region: TTC; TIGR02089
563174006488	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
563174006489	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
563174006490	substrate binding site [chemical binding]; other site
563174006491	ligand binding site [chemical binding]; other site
563174006492	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
563174006493	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
563174006494	substrate binding site [chemical binding]; other site
563174006495	threonine dehydratase; Validated; Region: PRK08639
563174006496	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
563174006497	tetramer interface [polypeptide binding]; other site
563174006498	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174006499	catalytic residue [active]
563174006500	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
563174006501	alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252
563174006502	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
563174006503	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
563174006504	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
563174006505	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
563174006506	Transcriptional regulators [Transcription]; Region: PurR; COG1609
563174006507	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
563174006508	DNA binding site [nucleotide binding]
563174006509	domain linker motif; other site
563174006510	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
563174006511	dimerization interface [polypeptide binding]; other site
563174006512	ligand binding site [chemical binding]; other site
563174006513	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
563174006514	intersubunit interface [polypeptide binding]; other site
563174006515	active site
563174006516	catalytic residue [active]
563174006517	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
563174006518	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
563174006519	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
563174006520	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
563174006521	active pocket/dimerization site; other site
563174006522	active site
563174006523	phosphorylation site [posttranslational modification]
563174006524	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
563174006525	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
563174006526	putative active site [active]
563174006527	SIS domain; Region: SIS; pfam01380
563174006528	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
563174006529	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
563174006530	dimer interface [polypeptide binding]; other site
563174006531	active site
563174006532	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
563174006533	dimer interface [polypeptide binding]; other site
563174006534	active site
563174006535	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
563174006536	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
563174006537	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
563174006538	active site
563174006539	phosphorylation site [posttranslational modification]
563174006540	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
563174006541	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174006542	DNA-binding site [nucleotide binding]; DNA binding site
563174006543	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
563174006544	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
563174006545	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174006546	DNA-binding site [nucleotide binding]; DNA binding site
563174006547	UTRA domain; Region: UTRA; pfam07702
563174006548	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
563174006549	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
563174006550	active site
563174006551	catalytic tetrad [active]
563174006552	acetolactate synthase; Reviewed; Region: PRK08617
563174006553	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
563174006554	PYR/PP interface [polypeptide binding]; other site
563174006555	dimer interface [polypeptide binding]; other site
563174006556	TPP binding site [chemical binding]; other site
563174006557	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
563174006558	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
563174006559	TPP-binding site [chemical binding]; other site
563174006560	dimer interface [polypeptide binding]; other site
563174006561	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
563174006562	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
563174006563	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
563174006564	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
563174006565	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174006566	dimer interface [polypeptide binding]; other site
563174006567	conserved gate region; other site
563174006568	ABC-ATPase subunit interface; other site
563174006569	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
563174006570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174006571	dimer interface [polypeptide binding]; other site
563174006572	conserved gate region; other site
563174006573	ABC-ATPase subunit interface; other site
563174006574	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
563174006575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174006576	active site
563174006577	phosphorylation site [posttranslational modification]
563174006578	intermolecular recognition site; other site
563174006579	dimerization interface [polypeptide binding]; other site
563174006580	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
563174006581	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
563174006582	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
563174006583	dimerization interface [polypeptide binding]; other site
563174006584	Histidine kinase; Region: His_kinase; pfam06580
563174006585	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174006586	ATP binding site [chemical binding]; other site
563174006587	Mg2+ binding site [ion binding]; other site
563174006588	G-X-G motif; other site
563174006589	Predicted integral membrane protein [Function unknown]; Region: COG5578
563174006590	Uncharacterized conserved protein [Function unknown]; Region: COG3538
563174006591	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
563174006592	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
563174006593	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
563174006594	active site
563174006595	metal binding site [ion binding]; metal-binding site
563174006596	homodimer interface [polypeptide binding]; other site
563174006597	catalytic site [active]
563174006598	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
563174006599	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
563174006600	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
563174006601	active site
563174006602	catalytic site [active]
563174006603	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
563174006604	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
563174006605	DNA-binding site [nucleotide binding]; DNA binding site
563174006606	RNA-binding motif; other site
563174006607	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
563174006608	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
563174006609	active site
563174006610	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
563174006611	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
563174006612	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
563174006613	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
563174006614	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
563174006615	HIGH motif; other site
563174006616	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
563174006617	active site
563174006618	KMSKS motif; other site
563174006619	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
563174006620	tRNA binding surface [nucleotide binding]; other site
563174006621	anticodon binding site; other site
563174006622	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
563174006623	DivIVA protein; Region: DivIVA; pfam05103
563174006624	DivIVA domain; Region: DivI1A_domain; TIGR03544
563174006625	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
563174006626	HTH domain; Region: HTH_11; pfam08279
563174006627	3H domain; Region: 3H; pfam02829
563174006628	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
563174006629	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
563174006630	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
563174006631	catalytic residue [active]
563174006632	L-aspartate oxidase; Provisional; Region: PRK08071
563174006633	L-aspartate oxidase; Provisional; Region: PRK06175
563174006634	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
563174006635	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
563174006636	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
563174006637	dimerization interface [polypeptide binding]; other site
563174006638	active site
563174006639	quinolinate synthetase; Provisional; Region: PRK09375
563174006640	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
563174006641	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
563174006642	RNA binding surface [nucleotide binding]; other site
563174006643	YGGT family; Region: YGGT; pfam02325
563174006644	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
563174006645	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
563174006646	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
563174006647	catalytic residue [active]
563174006648	cell division protein FtsZ; Validated; Region: PRK09330
563174006649	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
563174006650	nucleotide binding site [chemical binding]; other site
563174006651	SulA interaction site; other site
563174006652	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
563174006653	Cell division protein FtsA; Region: FtsA; smart00842
563174006654	Cell division protein FtsA; Region: FtsA; pfam14450
563174006655	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
563174006656	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
563174006657	Cell division protein FtsQ; Region: FtsQ; pfam03799
563174006658	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
563174006659	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
563174006660	active site
563174006661	homodimer interface [polypeptide binding]; other site
563174006662	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
563174006663	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
563174006664	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
563174006665	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
563174006666	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
563174006667	Mg++ binding site [ion binding]; other site
563174006668	putative catalytic motif [active]
563174006669	putative substrate binding site [chemical binding]; other site
563174006670	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
563174006671	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
563174006672	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
563174006673	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
563174006674	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
563174006675	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
563174006676	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
563174006677	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
563174006678	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
563174006679	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
563174006680	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
563174006681	MraW methylase family; Region: Methyltransf_5; pfam01795
563174006682	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
563174006683	MraZ protein; Region: MraZ; pfam02381
563174006684	MraZ protein; Region: MraZ; pfam02381
563174006685	Major Facilitator Superfamily; Region: MFS_1; pfam07690
563174006686	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174006687	putative substrate translocation pore; other site
563174006688	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
563174006689	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
563174006690	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
563174006691	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
563174006692	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
563174006693	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
563174006694	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
563174006695	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
563174006696	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
563174006697	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
563174006698	hypothetical protein; Provisional; Region: PRK13670
563174006699	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
563174006700	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
563174006701	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174006702	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14267
563174006703	Walker A/P-loop; other site
563174006704	ATP binding site [chemical binding]; other site
563174006705	Q-loop/lid; other site
563174006706	ABC transporter signature motif; other site
563174006707	Walker B; other site
563174006708	D-loop; other site
563174006709	H-loop/switch region; other site
563174006710	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
563174006711	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
563174006712	protein binding site [polypeptide binding]; other site
563174006713	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
563174006714	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
563174006715	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
563174006716	active site
563174006717	(T/H)XGH motif; other site
563174006718	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
563174006719	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174006720	S-adenosylmethionine binding site [chemical binding]; other site
563174006721	hypothetical protein; Provisional; Region: PRK02886
563174006722	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
563174006723	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
563174006724	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
563174006725	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
563174006726	UbiA prenyltransferase family; Region: UbiA; pfam01040
563174006727	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
563174006728	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
563174006729	Ion transport protein; Region: Ion_trans; pfam00520
563174006730	Ion channel; Region: Ion_trans_2; pfam07885
563174006731	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
563174006732	MOSC domain; Region: MOSC; pfam03473
563174006733	3-alpha domain; Region: 3-alpha; pfam03475
563174006734	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
563174006735	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
563174006736	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
563174006737	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953
563174006738	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
563174006739	Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056
563174006740	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
563174006741	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
563174006742	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
563174006743	active site
563174006744	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
563174006745	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
563174006746	ring oligomerisation interface [polypeptide binding]; other site
563174006747	ATP/Mg binding site [chemical binding]; other site
563174006748	stacking interactions; other site
563174006749	hinge regions; other site
563174006750	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
563174006751	oligomerisation interface [polypeptide binding]; other site
563174006752	mobile loop; other site
563174006753	roof hairpin; other site
563174006754	CAAX protease self-immunity; Region: Abi; pfam02517
563174006755	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
563174006756	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
563174006757	CoA binding domain; Region: CoA_binding; pfam02629
563174006758	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
563174006759	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
563174006760	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174006761	Q-loop/lid; other site
563174006762	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
563174006763	ABC transporter signature motif; other site
563174006764	Walker B; other site
563174006765	D-loop; other site
563174006766	ABC transporter; Region: ABC_tran_2; pfam12848
563174006767	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
563174006768	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
563174006769	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
563174006770	UGMP family protein; Validated; Region: PRK09604
563174006771	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
563174006772	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
563174006773	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174006774	Coenzyme A binding pocket [chemical binding]; other site
563174006775	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
563174006776	Glycoprotease family; Region: Peptidase_M22; pfam00814
563174006777	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
563174006778	camphor resistance protein CrcB; Provisional; Region: PRK14214
563174006779	camphor resistance protein CrcB; Provisional; Region: PRK14231
563174006780	Uncharacterized conserved protein [Function unknown]; Region: COG4832
563174006781	Phosphotransferase enzyme family; Region: APH; pfam01636
563174006782	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
563174006783	active site
563174006784	substrate binding site [chemical binding]; other site
563174006785	ATP binding site [chemical binding]; other site
563174006786	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
563174006787	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
563174006788	active site
563174006789	DNA binding site [nucleotide binding]
563174006790	Int/Topo IB signature motif; other site
563174006791	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
563174006792	Catalytic domain of Protein Kinases; Region: PKc; cd00180
563174006793	active site
563174006794	ATP binding site [chemical binding]; other site
563174006795	substrate binding site [chemical binding]; other site
563174006796	activation loop (A-loop); other site
563174006797	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
563174006798	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
563174006799	catalytic residues [active]
563174006800	catalytic nucleophile [active]
563174006801	Presynaptic Site I dimer interface [polypeptide binding]; other site
563174006802	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
563174006803	Synaptic Flat tetramer interface [polypeptide binding]; other site
563174006804	Synaptic Site I dimer interface [polypeptide binding]; other site
563174006805	DNA binding site [nucleotide binding]
563174006806	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
563174006807	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174006808	non-specific DNA binding site [nucleotide binding]; other site
563174006809	salt bridge; other site
563174006810	sequence-specific DNA binding site [nucleotide binding]; other site
563174006811	Cna protein B-type domain; Region: Cna_B; pfam05738
563174006812	Cna protein B-type domain; Region: Cna_B; pfam05738
563174006813	Cna protein B-type domain; Region: Cna_B; pfam05738
563174006814	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
563174006815	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174006816	non-specific DNA binding site [nucleotide binding]; other site
563174006817	salt bridge; other site
563174006818	sequence-specific DNA binding site [nucleotide binding]; other site
563174006819	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
563174006820	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
563174006821	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
563174006822	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
563174006823	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
563174006824	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
563174006825	substrate binding pocket [chemical binding]; other site
563174006826	argininosuccinate synthase; Provisional; Region: PRK13820
563174006827	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
563174006828	ANP binding site [chemical binding]; other site
563174006829	Substrate Binding Site II [chemical binding]; other site
563174006830	Substrate Binding Site I [chemical binding]; other site
563174006831	argininosuccinate lyase; Provisional; Region: PRK00855
563174006832	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
563174006833	active sites [active]
563174006834	tetramer interface [polypeptide binding]; other site
563174006835	BCCT family transporter; Region: BCCT; pfam02028
563174006836	hypothetical protein; Provisional; Region: PRK06357
563174006837	active site
563174006838	intersubunit interface [polypeptide binding]; other site
563174006839	Zn2+ binding site [ion binding]; other site
563174006840	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
563174006841	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
563174006842	putative substrate binding site [chemical binding]; other site
563174006843	putative ATP binding site [chemical binding]; other site
563174006844	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
563174006845	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
563174006846	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
563174006847	active site
563174006848	P-loop; other site
563174006849	phosphorylation site [posttranslational modification]
563174006850	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174006851	active site
563174006852	phosphorylation site [posttranslational modification]
563174006853	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
563174006854	PRD domain; Region: PRD; pfam00874
563174006855	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
563174006856	active site
563174006857	P-loop; other site
563174006858	phosphorylation site [posttranslational modification]
563174006859	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762
563174006860	active site
563174006861	phosphorylation site [posttranslational modification]
563174006862	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
563174006863	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174006864	DNA-binding site [nucleotide binding]; DNA binding site
563174006865	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
563174006866	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174006867	homodimer interface [polypeptide binding]; other site
563174006868	catalytic residue [active]
563174006869	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
563174006870	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
563174006871	active site
563174006872	multimer interface [polypeptide binding]; other site
563174006873	imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188
563174006874	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
563174006875	predicted active site [active]
563174006876	catalytic triad [active]
563174006877	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
563174006878	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
563174006879	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
563174006880	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
563174006881	G1 box; other site
563174006882	GTP/Mg2+ binding site [chemical binding]; other site
563174006883	Switch I region; other site
563174006884	G2 box; other site
563174006885	G3 box; other site
563174006886	Switch II region; other site
563174006887	G4 box; other site
563174006888	G5 box; other site
563174006889	Nucleoside recognition; Region: Gate; pfam07670
563174006890	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
563174006891	Nucleoside recognition; Region: Gate; pfam07670
563174006892	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
563174006893	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
563174006894	putative active site [active]
563174006895	putative metal binding site [ion binding]; other site
563174006896	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
563174006897	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
563174006898	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
563174006899	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
563174006900	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
563174006901	active site
563174006902	dimer interface [polypeptide binding]; other site
563174006903	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
563174006904	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
563174006905	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
563174006906	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
563174006907	dimer interface [polypeptide binding]; other site
563174006908	FMN binding site [chemical binding]; other site
563174006909	NADPH bind site [chemical binding]; other site
563174006910	Helix-turn-helix domain; Region: HTH_17; pfam12728
563174006911	putative heme peroxidase; Provisional; Region: PRK12276
563174006912	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
563174006913	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
563174006914	Walker A/P-loop; other site
563174006915	ATP binding site [chemical binding]; other site
563174006916	Q-loop/lid; other site
563174006917	ABC transporter signature motif; other site
563174006918	Walker B; other site
563174006919	D-loop; other site
563174006920	H-loop/switch region; other site
563174006921	FtsX-like permease family; Region: FtsX; pfam02687
563174006922	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174006923	Coenzyme A binding pocket [chemical binding]; other site
563174006924	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
563174006925	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
563174006926	active site
563174006927	substrate binding site [chemical binding]; other site
563174006928	metal binding site [ion binding]; metal-binding site
563174006929	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
563174006930	YbbR-like protein; Region: YbbR; pfam07949
563174006931	YbbR-like protein; Region: YbbR; pfam07949
563174006932	YbbR-like protein; Region: YbbR; pfam07949
563174006933	Uncharacterized conserved protein [Function unknown]; Region: COG1624
563174006934	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
563174006935	maltose phosphorylase; Provisional; Region: PRK13807
563174006936	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
563174006937	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
563174006938	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
563174006939	Predicted integral membrane protein [Function unknown]; Region: COG5521
563174006940	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
563174006941	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174006942	dimer interface [polypeptide binding]; other site
563174006943	conserved gate region; other site
563174006944	putative PBP binding loops; other site
563174006945	ABC-ATPase subunit interface; other site
563174006946	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174006947	dimer interface [polypeptide binding]; other site
563174006948	conserved gate region; other site
563174006949	putative PBP binding loops; other site
563174006950	ABC-ATPase subunit interface; other site
563174006951	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
563174006952	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
563174006953	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
563174006954	homodimer interface [polypeptide binding]; other site
563174006955	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
563174006956	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
563174006957	active site
563174006958	homodimer interface [polypeptide binding]; other site
563174006959	catalytic site [active]
563174006960	CAAX protease self-immunity; Region: Abi; cl00558
563174006961	Transcriptional regulators [Transcription]; Region: PurR; COG1609
563174006962	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
563174006963	DNA binding site [nucleotide binding]
563174006964	domain linker motif; other site
563174006965	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
563174006966	ligand binding site [chemical binding]; other site
563174006967	dimerization interface [polypeptide binding]; other site
563174006968	Amino acid permease; Region: AA_permease_2; pfam13520
563174006969	K+ potassium transporter; Region: K_trans; cl15781
563174006970	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174006971	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
563174006972	ligand binding site [chemical binding]; other site
563174006973	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174006974	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
563174006975	ligand binding site [chemical binding]; other site
563174006976	flexible hinge region; other site
563174006977	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
563174006978	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
563174006979	intersubunit interface [polypeptide binding]; other site
563174006980	active site
563174006981	zinc binding site [ion binding]; other site
563174006982	Na+ binding site [ion binding]; other site
563174006983	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
563174006984	intersubunit interface [polypeptide binding]; other site
563174006985	active site
563174006986	zinc binding site [ion binding]; other site
563174006987	Na+ binding site [ion binding]; other site
563174006988	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
563174006989	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
563174006990	active site
563174006991	P-loop; other site
563174006992	phosphorylation site [posttranslational modification]
563174006993	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174006994	active site
563174006995	phosphorylation site [posttranslational modification]
563174006996	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
563174006997	HTH domain; Region: HTH_11; pfam08279
563174006998	PRD domain; Region: PRD; pfam00874
563174006999	PRD domain; Region: PRD; pfam00874
563174007000	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
563174007001	active site
563174007002	P-loop; other site
563174007003	phosphorylation site [posttranslational modification]
563174007004	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
563174007005	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174007006	Walker A/P-loop; other site
563174007007	ATP binding site [chemical binding]; other site
563174007008	Q-loop/lid; other site
563174007009	ABC transporter signature motif; other site
563174007010	Walker B; other site
563174007011	D-loop; other site
563174007012	H-loop/switch region; other site
563174007013	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
563174007014	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
563174007015	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
563174007016	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174007017	Coenzyme A binding pocket [chemical binding]; other site
563174007018	Transcriptional regulators [Transcription]; Region: GntR; COG1802
563174007019	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
563174007020	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
563174007021	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
563174007022	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174007023	DNA-binding site [nucleotide binding]; DNA binding site
563174007024	UTRA domain; Region: UTRA; pfam07702
563174007025	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
563174007026	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
563174007027	Transcriptional regulator [Transcription]; Region: LysR; COG0583
563174007028	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
563174007029	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
563174007030	putative dimerization interface [polypeptide binding]; other site
563174007031	Predicted membrane protein [Function unknown]; Region: COG2855
563174007032	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
563174007033	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
563174007034	putative metal binding site [ion binding]; other site
563174007035	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
563174007036	homodimer interface [polypeptide binding]; other site
563174007037	chemical substrate binding site [chemical binding]; other site
563174007038	oligomer interface [polypeptide binding]; other site
563174007039	metal binding site [ion binding]; metal-binding site
563174007040	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
563174007041	catalytic residues [active]
563174007042	flavodoxin; Provisional; Region: PRK09271
563174007043	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
563174007044	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
563174007045	dimer interface [polypeptide binding]; other site
563174007046	putative radical transfer pathway; other site
563174007047	diiron center [ion binding]; other site
563174007048	tyrosyl radical; other site
563174007049	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209
563174007050	Class I ribonucleotide reductase; Region: RNR_I; cd01679
563174007051	active site
563174007052	dimer interface [polypeptide binding]; other site
563174007053	catalytic residues [active]
563174007054	effector binding site; other site
563174007055	R2 peptide binding site; other site
563174007056	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
563174007057	CsbD-like; Region: CsbD; cl17424
563174007058	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
563174007059	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
563174007060	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
563174007061	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
563174007062	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
563174007063	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
563174007064	conserved cys residue [active]
563174007065	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
563174007066	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
563174007067	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
563174007068	Cupin domain; Region: Cupin_2; pfam07883
563174007069	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
563174007070	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
563174007071	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174007072	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
563174007073	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174007074	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
563174007075	ligand binding site [chemical binding]; other site
563174007076	flexible hinge region; other site
563174007077	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
563174007078	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
563174007079	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
563174007080	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
563174007081	dimer interface [polypeptide binding]; other site
563174007082	active site
563174007083	metal binding site [ion binding]; metal-binding site
563174007084	glutathione binding site [chemical binding]; other site
563174007085	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
563174007086	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
563174007087	FMN binding site [chemical binding]; other site
563174007088	substrate binding site [chemical binding]; other site
563174007089	putative catalytic residue [active]
563174007090	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
563174007091	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
563174007092	Coenzyme A transferase; Region: CoA_trans; smart00882
563174007093	Coenzyme A transferase; Region: CoA_trans; cl17247
563174007094	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
563174007095	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174007096	Walker A motif; other site
563174007097	ATP binding site [chemical binding]; other site
563174007098	Walker B motif; other site
563174007099	arginine finger; other site
563174007100	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
563174007101	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
563174007102	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
563174007103	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
563174007104	metal binding site [ion binding]; metal-binding site
563174007105	active site
563174007106	I-site; other site
563174007107	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
563174007108	classical (c) SDRs; Region: SDR_c; cd05233
563174007109	NAD(P) binding site [chemical binding]; other site
563174007110	active site
563174007111	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
563174007112	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
563174007113	Tic20-like protein; Region: Tic20; pfam09685
563174007114	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
563174007115	Collagen binding domain; Region: Collagen_bind; pfam05737
563174007116	Cna protein B-type domain; Region: Cna_B; pfam05738
563174007117	Cna protein B-type domain; Region: Cna_B; pfam05738
563174007118	Cna protein B-type domain; Region: Cna_B; pfam05738
563174007119	Cna protein B-type domain; Region: Cna_B; pfam05738
563174007120	Cna protein B-type domain; Region: Cna_B; pfam05738
563174007121	Cna protein B-type domain; Region: Cna_B; pfam05738
563174007122	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174007123	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
563174007124	Cna protein B-type domain; Region: Cna_B; pfam05738
563174007125	Collagen binding domain; Region: Collagen_bind; pfam05737
563174007126	Cna protein B-type domain; Region: Cna_B; pfam05738
563174007127	Cna protein B-type domain; Region: Cna_B; pfam05738
563174007128	Cna protein B-type domain; Region: Cna_B; pfam05738
563174007129	Cna protein B-type domain; Region: Cna_B; pfam05738
563174007130	Cna protein B-type domain; Region: Cna_B; pfam05738
563174007131	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174007132	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174007133	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174007134	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
563174007135	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
563174007136	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
563174007137	active site
563174007138	catalytic site [active]
563174007139	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
563174007140	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
563174007141	Walker A/P-loop; other site
563174007142	ATP binding site [chemical binding]; other site
563174007143	Q-loop/lid; other site
563174007144	ABC transporter signature motif; other site
563174007145	Walker B; other site
563174007146	D-loop; other site
563174007147	H-loop/switch region; other site
563174007148	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
563174007149	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
563174007150	ABC-ATPase subunit  interface; other site
563174007151	dimer interface [polypeptide binding]; other site
563174007152	putative PBP binding regions; other site
563174007153	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
563174007154	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
563174007155	intersubunit interface [polypeptide binding]; other site
563174007156	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
563174007157	heme-binding site [chemical binding]; other site
563174007158	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
563174007159	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
563174007160	heme-binding site [chemical binding]; other site
563174007161	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
563174007162	heme-binding site [chemical binding]; other site
563174007163	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
563174007164	heme uptake protein IsdC; Region: IsdC; TIGR03656
563174007165	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
563174007166	heme-binding site [chemical binding]; other site
563174007167	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
563174007168	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
563174007169	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
563174007170	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
563174007171	active site
563174007172	Zn binding site [ion binding]; other site
563174007173	Competence protein CoiA-like family; Region: CoiA; cl11541
563174007174	Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862
563174007175	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
563174007176	ArsC family; Region: ArsC; pfam03960
563174007177	putative catalytic residues [active]
563174007178	thiol/disulfide switch; other site
563174007179	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
563174007180	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
563174007181	Walker A/P-loop; other site
563174007182	ATP binding site [chemical binding]; other site
563174007183	Q-loop/lid; other site
563174007184	ABC transporter signature motif; other site
563174007185	Walker B; other site
563174007186	D-loop; other site
563174007187	H-loop/switch region; other site
563174007188	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
563174007189	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
563174007190	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
563174007191	Walker A/P-loop; other site
563174007192	ATP binding site [chemical binding]; other site
563174007193	Q-loop/lid; other site
563174007194	ABC transporter signature motif; other site
563174007195	Walker B; other site
563174007196	D-loop; other site
563174007197	H-loop/switch region; other site
563174007198	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
563174007199	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
563174007200	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174007201	dimer interface [polypeptide binding]; other site
563174007202	conserved gate region; other site
563174007203	putative PBP binding loops; other site
563174007204	ABC-ATPase subunit interface; other site
563174007205	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
563174007206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174007207	dimer interface [polypeptide binding]; other site
563174007208	conserved gate region; other site
563174007209	putative PBP binding loops; other site
563174007210	ABC-ATPase subunit interface; other site
563174007211	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
563174007212	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
563174007213	peptide binding site [polypeptide binding]; other site
563174007214	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
563174007215	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
563174007216	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
563174007217	active site
563174007218	HIGH motif; other site
563174007219	dimer interface [polypeptide binding]; other site
563174007220	KMSKS motif; other site
563174007221	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
563174007222	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
563174007223	MarR family; Region: MarR; pfam01047
563174007224	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
563174007225	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
563174007226	dimer interface [polypeptide binding]; other site
563174007227	active site
563174007228	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
563174007229	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
563174007230	dimer interface [polypeptide binding]; other site
563174007231	active site
563174007232	CoA binding pocket [chemical binding]; other site
563174007233	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
563174007234	SH3-like domain; Region: SH3_8; pfam13457
563174007235	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
563174007236	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
563174007237	catalytic core [active]
563174007238	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
563174007239	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
563174007240	Clp amino terminal domain; Region: Clp_N; pfam02861
563174007241	Clp amino terminal domain; Region: Clp_N; pfam02861
563174007242	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174007243	Walker A motif; other site
563174007244	ATP binding site [chemical binding]; other site
563174007245	Walker B motif; other site
563174007246	arginine finger; other site
563174007247	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174007248	Walker A motif; other site
563174007249	ATP binding site [chemical binding]; other site
563174007250	Walker B motif; other site
563174007251	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
563174007252	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
563174007253	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
563174007254	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
563174007255	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174007256	active site
563174007257	motif I; other site
563174007258	motif II; other site
563174007259	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
563174007260	Predicted acetyltransferase [General function prediction only]; Region: COG3393
563174007261	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
563174007262	ferrochelatase; Provisional; Region: PRK12435
563174007263	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
563174007264	C-terminal domain interface [polypeptide binding]; other site
563174007265	active site
563174007266	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
563174007267	active site
563174007268	N-terminal domain interface [polypeptide binding]; other site
563174007269	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
563174007270	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
563174007271	substrate binding site [chemical binding]; other site
563174007272	active site
563174007273	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
563174007274	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
563174007275	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
563174007276	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
563174007277	Walker A/P-loop; other site
563174007278	ATP binding site [chemical binding]; other site
563174007279	Q-loop/lid; other site
563174007280	ABC transporter signature motif; other site
563174007281	Walker B; other site
563174007282	D-loop; other site
563174007283	H-loop/switch region; other site
563174007284	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
563174007285	HIT family signature motif; other site
563174007286	catalytic residue [active]
563174007287	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
563174007288	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
563174007289	SurA N-terminal domain; Region: SurA_N_3; cl07813
563174007290	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
563174007291	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
563174007292	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
563174007293	generic binding surface II; other site
563174007294	generic binding surface I; other site
563174007295	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
563174007296	Zn2+ binding site [ion binding]; other site
563174007297	Mg2+ binding site [ion binding]; other site
563174007298	Uncharacterized conserved protein [Function unknown]; Region: COG4717
563174007299	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
563174007300	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
563174007301	active site
563174007302	metal binding site [ion binding]; metal-binding site
563174007303	DNA binding site [nucleotide binding]
563174007304	hypothetical protein; Provisional; Region: PRK13676
563174007305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
563174007306	fumarate hydratase; Reviewed; Region: fumC; PRK00485
563174007307	Class II fumarases; Region: Fumarase_classII; cd01362
563174007308	active site
563174007309	tetramer interface [polypeptide binding]; other site
563174007310	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
563174007311	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
563174007312	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
563174007313	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
563174007314	Walker A/P-loop; other site
563174007315	ATP binding site [chemical binding]; other site
563174007316	Q-loop/lid; other site
563174007317	ABC transporter signature motif; other site
563174007318	Walker B; other site
563174007319	D-loop; other site
563174007320	H-loop/switch region; other site
563174007321	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
563174007322	Transglycosylase; Region: Transgly; pfam00912
563174007323	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
563174007324	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
563174007325	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
563174007326	Low molecular weight phosphatase family; Region: LMWPc; cl00105
563174007327	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
563174007328	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
563174007329	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
563174007330	Domain of unknown function DUF21; Region: DUF21; pfam01595
563174007331	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
563174007332	Transporter associated domain; Region: CorC_HlyC; smart01091
563174007333	Transcriptional regulator [Transcription]; Region: LysR; COG0583
563174007334	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
563174007335	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
563174007336	putative dimerization interface [polypeptide binding]; other site
563174007337	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
563174007338	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
563174007339	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
563174007340	active site
563174007341	FMN binding site [chemical binding]; other site
563174007342	substrate binding site [chemical binding]; other site
563174007343	putative catalytic residue [active]
563174007344	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
563174007345	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
563174007346	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
563174007347	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
563174007348	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
563174007349	shikimate binding site; other site
563174007350	NAD(P) binding site [chemical binding]; other site
563174007351	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174007352	putative substrate translocation pore; other site
563174007353	Major Facilitator Superfamily; Region: MFS_1; pfam07690
563174007354	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174007355	Major Facilitator Superfamily; Region: MFS_1; pfam07690
563174007356	putative substrate translocation pore; other site
563174007357	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
563174007358	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174007359	Walker A/P-loop; other site
563174007360	ATP binding site [chemical binding]; other site
563174007361	Q-loop/lid; other site
563174007362	ABC transporter signature motif; other site
563174007363	Walker B; other site
563174007364	D-loop; other site
563174007365	H-loop/switch region; other site
563174007366	Predicted transcriptional regulators [Transcription]; Region: COG1725
563174007367	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
563174007368	DNA-binding site [nucleotide binding]; DNA binding site
563174007369	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
563174007370	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
563174007371	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
563174007372	DNA binding site [nucleotide binding]
563174007373	active site
563174007374	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
563174007375	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
563174007376	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
563174007377	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
563174007378	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
563174007379	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
563174007380	active site
563174007381	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
563174007382	putative dimer interface [polypeptide binding]; other site
563174007383	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
563174007384	ligand binding site [chemical binding]; other site
563174007385	Zn binding site [ion binding]; other site
563174007386	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
563174007387	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
563174007388	active site
563174007389	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
563174007390	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
563174007391	active site
563174007392	catalytic tetrad [active]
563174007393	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
563174007394	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
563174007395	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
563174007396	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
563174007397	substrate binding pocket [chemical binding]; other site
563174007398	membrane-bound complex binding site; other site
563174007399	hinge residues; other site
563174007400	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
563174007401	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174007402	dimer interface [polypeptide binding]; other site
563174007403	conserved gate region; other site
563174007404	putative PBP binding loops; other site
563174007405	ABC-ATPase subunit interface; other site
563174007406	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
563174007407	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
563174007408	Walker A/P-loop; other site
563174007409	ATP binding site [chemical binding]; other site
563174007410	Q-loop/lid; other site
563174007411	ABC transporter signature motif; other site
563174007412	Walker B; other site
563174007413	D-loop; other site
563174007414	H-loop/switch region; other site
563174007415	aspartate aminotransferase; Provisional; Region: PRK06348
563174007416	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
563174007417	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174007418	homodimer interface [polypeptide binding]; other site
563174007419	catalytic residue [active]
563174007420	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
563174007421	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
563174007422	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174007423	motif II; other site
563174007424	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
563174007425	intracellular protease, PfpI family; Region: PfpI; TIGR01382
563174007426	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
563174007427	proposed catalytic triad [active]
563174007428	conserved cys residue [active]
563174007429	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
563174007430	methionine cluster; other site
563174007431	active site
563174007432	phosphorylation site [posttranslational modification]
563174007433	metal binding site [ion binding]; metal-binding site
563174007434	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174007435	Coenzyme A binding pocket [chemical binding]; other site
563174007436	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
563174007437	esterase; Provisional; Region: PRK10566
563174007438	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
563174007439	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
563174007440	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
563174007441	motif II; other site
563174007442	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174007443	Uncharacterized conserved protein [Function unknown]; Region: COG1284
563174007444	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
563174007445	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
563174007446	hypothetical protein; Provisional; Region: PRK13673
563174007447	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
563174007448	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
563174007449	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
563174007450	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
563174007451	Family description; Region: UvrD_C_2; pfam13538
563174007452	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
563174007453	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
563174007454	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
563174007455	IDEAL domain; Region: IDEAL; pfam08858
563174007456	ComK protein; Region: ComK; cl11560
563174007457	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
563174007458	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174007459	non-specific DNA binding site [nucleotide binding]; other site
563174007460	salt bridge; other site
563174007461	sequence-specific DNA binding site [nucleotide binding]; other site
563174007462	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
563174007463	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174007464	active site
563174007465	phosphorylation site [posttranslational modification]
563174007466	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
563174007467	active site
563174007468	P-loop; other site
563174007469	phosphorylation site [posttranslational modification]
563174007470	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
563174007471	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
563174007472	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
563174007473	putative substrate binding site [chemical binding]; other site
563174007474	putative ATP binding site [chemical binding]; other site
563174007475	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
563174007476	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
563174007477	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
563174007478	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
563174007479	trimer interface [polypeptide binding]; other site
563174007480	active site
563174007481	G bulge; other site
563174007482	Uncharacterized conserved protein [Function unknown]; Region: COG1683
563174007483	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
563174007484	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
563174007485	non-specific DNA interactions [nucleotide binding]; other site
563174007486	DNA binding site [nucleotide binding]
563174007487	sequence specific DNA binding site [nucleotide binding]; other site
563174007488	putative cAMP binding site [chemical binding]; other site
563174007489	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
563174007490	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
563174007491	substrate binding site [chemical binding]; other site
563174007492	ATP binding site [chemical binding]; other site
563174007493	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
563174007494	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
563174007495	RNA binding surface [nucleotide binding]; other site
563174007496	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
563174007497	active site
563174007498	uracil binding [chemical binding]; other site
563174007499	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
563174007500	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
563174007501	active site
563174007502	non-prolyl cis peptide bond; other site
563174007503	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
563174007504	catalytic residues [active]
563174007505	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
563174007506	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
563174007507	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
563174007508	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
563174007509	Walker A/P-loop; other site
563174007510	ATP binding site [chemical binding]; other site
563174007511	Q-loop/lid; other site
563174007512	ABC transporter signature motif; other site
563174007513	Walker B; other site
563174007514	D-loop; other site
563174007515	H-loop/switch region; other site
563174007516	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
563174007517	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174007518	dimer interface [polypeptide binding]; other site
563174007519	conserved gate region; other site
563174007520	putative PBP binding loops; other site
563174007521	ABC-ATPase subunit interface; other site
563174007522	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
563174007523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174007524	dimer interface [polypeptide binding]; other site
563174007525	conserved gate region; other site
563174007526	putative PBP binding loops; other site
563174007527	ABC-ATPase subunit interface; other site
563174007528	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
563174007529	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
563174007530	substrate binding pocket [chemical binding]; other site
563174007531	membrane-bound complex binding site; other site
563174007532	hinge residues; other site
563174007533	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174007534	Coenzyme A binding pocket [chemical binding]; other site
563174007535	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
563174007536	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
563174007537	Transcriptional regulator [Transcription]; Region: LysR; COG0583
563174007538	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
563174007539	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
563174007540	dimerization interface [polypeptide binding]; other site
563174007541	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
563174007542	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
563174007543	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
563174007544	active site
563174007545	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174007546	Major Facilitator Superfamily; Region: MFS_1; pfam07690
563174007547	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174007548	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
563174007549	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
563174007550	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
563174007551	active site
563174007552	trimer interface [polypeptide binding]; other site
563174007553	allosteric site; other site
563174007554	active site lid [active]
563174007555	hexamer (dimer of trimers) interface [polypeptide binding]; other site
563174007556	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
563174007557	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
563174007558	Predicted membrane protein [Function unknown]; Region: COG1511
563174007559	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
563174007560	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
563174007561	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
563174007562	Predicted transcriptional regulator [Transcription]; Region: COG1959
563174007563	Transcriptional regulator; Region: Rrf2; pfam02082
563174007564	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
563174007565	ADP-ribose binding site [chemical binding]; other site
563174007566	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
563174007567	L-tyrosine decarboxylase; Provisional; Region: PRK13520
563174007568	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
563174007569	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174007570	catalytic residue [active]
563174007571	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
563174007572	Mga helix-turn-helix domain; Region: Mga; pfam05043
563174007573	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
563174007574	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
563174007575	ADP-ribose binding site [chemical binding]; other site
563174007576	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
563174007577	active site
563174007578	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
563174007579	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
563174007580	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
563174007581	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
563174007582	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
563174007583	active site
563174007584	dimer interface [polypeptide binding]; other site
563174007585	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
563174007586	dimer interface [polypeptide binding]; other site
563174007587	active site
563174007588	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
563174007589	nudix motif; other site
563174007590	general stress protein 13; Validated; Region: PRK08059
563174007591	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
563174007592	RNA binding site [nucleotide binding]; other site
563174007593	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
563174007594	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
563174007595	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174007596	homodimer interface [polypeptide binding]; other site
563174007597	catalytic residue [active]
563174007598	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
563174007599	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
563174007600	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
563174007601	Walker A/P-loop; other site
563174007602	ATP binding site [chemical binding]; other site
563174007603	Q-loop/lid; other site
563174007604	ABC transporter signature motif; other site
563174007605	Walker B; other site
563174007606	D-loop; other site
563174007607	H-loop/switch region; other site
563174007608	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
563174007609	active site
563174007610	P-loop; other site
563174007611	phosphorylation site [posttranslational modification]
563174007612	aspartate kinase; Reviewed; Region: PRK09034
563174007613	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
563174007614	putative catalytic residues [active]
563174007615	putative nucleotide binding site [chemical binding]; other site
563174007616	putative aspartate binding site [chemical binding]; other site
563174007617	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
563174007618	allosteric regulatory residue; other site
563174007619	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
563174007620	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
563174007621	putative active site [active]
563174007622	putative NTP binding site [chemical binding]; other site
563174007623	putative nucleic acid binding site [nucleotide binding]; other site
563174007624	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
563174007625	active site
563174007626	drug efflux system protein MdtG; Provisional; Region: PRK09874
563174007627	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174007628	putative substrate translocation pore; other site
563174007629	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
563174007630	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
563174007631	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
563174007632	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
563174007633	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
563174007634	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
563174007635	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
563174007636	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
563174007637	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
563174007638	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585
563174007639	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
563174007640	CoenzymeA binding site [chemical binding]; other site
563174007641	subunit interaction site [polypeptide binding]; other site
563174007642	PHB binding site; other site
563174007643	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963
563174007644	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
563174007645	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
563174007646	Cl- selectivity filter; other site
563174007647	Cl- binding residues [ion binding]; other site
563174007648	pore gating glutamate residue; other site
563174007649	dimer interface [polypeptide binding]; other site
563174007650	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
563174007651	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
563174007652	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
563174007653	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
563174007654	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
563174007655	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
563174007656	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
563174007657	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
563174007658	NADH(P)-binding; Region: NAD_binding_10; pfam13460
563174007659	NAD(P) binding site [chemical binding]; other site
563174007660	putative active site [active]
563174007661	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844
563174007662	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
563174007663	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
563174007664	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
563174007665	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174007666	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174007667	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174007668	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174007669	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174007670	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
563174007671	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
563174007672	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
563174007673	tetramer interfaces [polypeptide binding]; other site
563174007674	binuclear metal-binding site [ion binding]; other site
563174007675	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
563174007676	Domain of unknown function DUF21; Region: DUF21; pfam01595
563174007677	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
563174007678	Transporter associated domain; Region: CorC_HlyC; smart01091
563174007679	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
563174007680	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174007681	Coenzyme A binding pocket [chemical binding]; other site
563174007682	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
563174007683	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174007684	active site
563174007685	motif I; other site
563174007686	motif II; other site
563174007687	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174007688	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
563174007689	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
563174007690	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
563174007691	active site
563174007692	metal binding site [ion binding]; metal-binding site
563174007693	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
563174007694	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
563174007695	Predicted membrane protein [Function unknown]; Region: COG4272
563174007696	Uncharacterized conserved protein [Function unknown]; Region: COG1801
563174007697	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
563174007698	FeS assembly protein SufB; Region: sufB; TIGR01980
563174007699	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
563174007700	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
563174007701	trimerization site [polypeptide binding]; other site
563174007702	active site
563174007703	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
563174007704	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
563174007705	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
563174007706	catalytic residue [active]
563174007707	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
563174007708	FeS assembly protein SufD; Region: sufD; TIGR01981
563174007709	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
563174007710	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
563174007711	Walker A/P-loop; other site
563174007712	ATP binding site [chemical binding]; other site
563174007713	Q-loop/lid; other site
563174007714	ABC transporter signature motif; other site
563174007715	Walker B; other site
563174007716	D-loop; other site
563174007717	H-loop/switch region; other site
563174007718	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
563174007719	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
563174007720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174007721	ABC-ATPase subunit interface; other site
563174007722	putative PBP binding loops; other site
563174007723	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
563174007724	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
563174007725	Walker A/P-loop; other site
563174007726	ATP binding site [chemical binding]; other site
563174007727	Q-loop/lid; other site
563174007728	ABC transporter signature motif; other site
563174007729	Walker B; other site
563174007730	D-loop; other site
563174007731	H-loop/switch region; other site
563174007732	NIL domain; Region: NIL; pfam09383
563174007733	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
563174007734	dimer interface [polypeptide binding]; other site
563174007735	phosphorylation site [posttranslational modification]
563174007736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174007737	ATP binding site [chemical binding]; other site
563174007738	Mg2+ binding site [ion binding]; other site
563174007739	G-X-G motif; other site
563174007740	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
563174007741	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174007742	active site
563174007743	phosphorylation site [posttranslational modification]
563174007744	intermolecular recognition site; other site
563174007745	dimerization interface [polypeptide binding]; other site
563174007746	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
563174007747	DNA binding site [nucleotide binding]
563174007748	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
563174007749	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
563174007750	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
563174007751	catalytic residues [active]
563174007752	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
563174007753	lipoyl attachment site [posttranslational modification]; other site
563174007754	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
563174007755	ArsC family; Region: ArsC; pfam03960
563174007756	putative ArsC-like catalytic residues; other site
563174007757	putative TRX-like catalytic residues [active]
563174007758	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
563174007759	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
563174007760	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
563174007761	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
563174007762	Walker A/P-loop; other site
563174007763	ATP binding site [chemical binding]; other site
563174007764	Q-loop/lid; other site
563174007765	ABC transporter signature motif; other site
563174007766	Walker B; other site
563174007767	D-loop; other site
563174007768	H-loop/switch region; other site
563174007769	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
563174007770	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
563174007771	ABC-ATPase subunit  interface; other site
563174007772	dimer interface [polypeptide binding]; other site
563174007773	putative PBP binding regions; other site
563174007774	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
563174007775	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
563174007776	intersubunit interface [polypeptide binding]; other site
563174007777	Predicted esterase [General function prediction only]; Region: COG0627
563174007778	S-formylglutathione hydrolase; Region: PLN02442
563174007779	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
563174007780	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174007781	catalytic residue [active]
563174007782	SdpI/YhfL protein family; Region: SdpI; pfam13630
563174007783	CAT RNA binding domain; Region: CAT_RBD; smart01061
563174007784	transcriptional antiterminator BglG; Provisional; Region: PRK09772
563174007785	PRD domain; Region: PRD; pfam00874
563174007786	PRD domain; Region: PRD; pfam00874
563174007787	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
563174007788	Uncharacterized conserved protein [Function unknown]; Region: COG4283
563174007789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
563174007790	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
563174007791	Predicted transcriptional regulator [Transcription]; Region: COG2378
563174007792	HTH domain; Region: HTH_11; pfam08279
563174007793	WYL domain; Region: WYL; pfam13280
563174007794	Uncharacterized conserved protein [Function unknown]; Region: COG1434
563174007795	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
563174007796	putative active site [active]
563174007797	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
563174007798	Leucine rich repeat; Region: LRR_8; pfam13855
563174007799	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
563174007800	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
563174007801	active site
563174007802	catalytic site [active]
563174007803	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
563174007804	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
563174007805	putative metal binding site [ion binding]; other site
563174007806	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
563174007807	Leucine rich repeat; Region: LRR_8; pfam13855
563174007808	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
563174007809	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
563174007810	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
563174007811	active site
563174007812	catalytic site [active]
563174007813	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
563174007814	putative metal binding site [ion binding]; other site
563174007815	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174007816	non-specific DNA binding site [nucleotide binding]; other site
563174007817	salt bridge; other site
563174007818	sequence-specific DNA binding site [nucleotide binding]; other site
563174007819	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
563174007820	Tetratricopeptide repeat; Region: TPR_12; pfam13424
563174007821	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
563174007822	SmpB-tmRNA interface; other site
563174007823	ribonuclease R; Region: RNase_R; TIGR02063
563174007824	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
563174007825	RNB domain; Region: RNB; pfam00773
563174007826	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
563174007827	RNA binding site [nucleotide binding]; other site
563174007828	Esterase/lipase [General function prediction only]; Region: COG1647
563174007829	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
563174007830	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
563174007831	Preprotein translocase SecG subunit; Region: SecG; cl09123
563174007832	Esterase/lipase [General function prediction only]; Region: COG1647
563174007833	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
563174007834	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
563174007835	PGAP1-like protein; Region: PGAP1; pfam07819
563174007836	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
563174007837	enolase; Provisional; Region: eno; PRK00077
563174007838	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
563174007839	dimer interface [polypeptide binding]; other site
563174007840	metal binding site [ion binding]; metal-binding site
563174007841	substrate binding pocket [chemical binding]; other site
563174007842	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
563174007843	phosphoglyceromutase; Provisional; Region: PRK05434
563174007844	triosephosphate isomerase; Provisional; Region: PRK14567
563174007845	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
563174007846	substrate binding site [chemical binding]; other site
563174007847	dimer interface [polypeptide binding]; other site
563174007848	catalytic triad [active]
563174007849	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
563174007850	Phosphoglycerate kinase; Region: PGK; pfam00162
563174007851	substrate binding site [chemical binding]; other site
563174007852	hinge regions; other site
563174007853	ADP binding site [chemical binding]; other site
563174007854	catalytic site [active]
563174007855	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
563174007856	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
563174007857	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
563174007858	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
563174007859	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
563174007860	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
563174007861	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
563174007862	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
563174007863	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
563174007864	DNA binding site [nucleotide binding]
563174007865	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
563174007866	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
563174007867	active site
563174007868	dimer interface [polypeptide binding]; other site
563174007869	MMPL family; Region: MMPL; pfam03176
563174007870	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
563174007871	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
563174007872	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
563174007873	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
563174007874	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
563174007875	Chitin binding domain; Region: Chitin_bind_3; pfam03067
563174007876	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
563174007877	Interdomain contacts; other site
563174007878	Cytokine receptor motif; other site
563174007879	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
563174007880	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
563174007881	Interdomain contacts; other site
563174007882	Cytokine receptor motif; other site
563174007883	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
563174007884	aromatic chitin/cellulose binding site residues [chemical binding]; other site
563174007885	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
563174007886	aromatic chitin/cellulose binding site residues [chemical binding]; other site
563174007887	Clp protease; Region: CLP_protease; pfam00574
563174007888	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
563174007889	oligomer interface [polypeptide binding]; other site
563174007890	active site residues [active]
563174007891	amino acid transporter; Region: 2A0306; TIGR00909
563174007892	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
563174007893	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
563174007894	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
563174007895	active site
563174007896	FMN binding site [chemical binding]; other site
563174007897	substrate binding site [chemical binding]; other site
563174007898	homotetramer interface [polypeptide binding]; other site
563174007899	catalytic residue [active]
563174007900	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
563174007901	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
563174007902	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
563174007903	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
563174007904	phosphate binding site [ion binding]; other site
563174007905	putative substrate binding pocket [chemical binding]; other site
563174007906	dimer interface [polypeptide binding]; other site
563174007907	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
563174007908	AAA domain; Region: AAA_18; pfam13238
563174007909	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
563174007910	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
563174007911	active site
563174007912	substrate binding site [chemical binding]; other site
563174007913	metal binding site [ion binding]; metal-binding site
563174007914	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
563174007915	active site
563174007916	catalytic residues [active]
563174007917	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
563174007918	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
563174007919	NAD binding site [chemical binding]; other site
563174007920	homodimer interface [polypeptide binding]; other site
563174007921	active site
563174007922	substrate binding site [chemical binding]; other site
563174007923	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
563174007924	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
563174007925	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
563174007926	TPR repeat; Region: TPR_11; pfam13414
563174007927	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
563174007928	binding surface
563174007929	TPR motif; other site
563174007930	Tetratricopeptide repeat; Region: TPR_12; pfam13424
563174007931	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
563174007932	binding surface
563174007933	TPR motif; other site
563174007934	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
563174007935	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
563174007936	putative trimer interface [polypeptide binding]; other site
563174007937	putative CoA binding site [chemical binding]; other site
563174007938	pyrophosphatase PpaX; Provisional; Region: PRK13288
563174007939	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
563174007940	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174007941	motif II; other site
563174007942	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
563174007943	HPr kinase/phosphorylase; Provisional; Region: PRK05428
563174007944	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
563174007945	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
563174007946	Hpr binding site; other site
563174007947	active site
563174007948	homohexamer subunit interaction site [polypeptide binding]; other site
563174007949	Predicted membrane protein [Function unknown]; Region: COG1950
563174007950	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
563174007951	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
563174007952	Uncharacterized conserved protein [Function unknown]; Region: COG3595
563174007953	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
563174007954	Uncharacterized conserved protein [Function unknown]; Region: COG3595
563174007955	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
563174007956	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
563174007957	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
563174007958	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
563174007959	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
563174007960	excinuclease ABC subunit B; Provisional; Region: PRK05298
563174007961	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
563174007962	ATP binding site [chemical binding]; other site
563174007963	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
563174007964	nucleotide binding region [chemical binding]; other site
563174007965	ATP-binding site [chemical binding]; other site
563174007966	Ultra-violet resistance protein B; Region: UvrB; pfam12344
563174007967	UvrB/uvrC motif; Region: UVR; pfam02151
563174007968	Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559
563174007969	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
563174007970	Zn2+ binding site [ion binding]; other site
563174007971	Mg2+ binding site [ion binding]; other site
563174007972	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
563174007973	dimerization interface [polypeptide binding]; other site
563174007974	putative DNA binding site [nucleotide binding]; other site
563174007975	putative Zn2+ binding site [ion binding]; other site
563174007976	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
563174007977	PhoU domain; Region: PhoU; pfam01895
563174007978	PhoU domain; Region: PhoU; pfam01895
563174007979	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
563174007980	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
563174007981	Walker A/P-loop; other site
563174007982	ATP binding site [chemical binding]; other site
563174007983	Q-loop/lid; other site
563174007984	ABC transporter signature motif; other site
563174007985	Walker B; other site
563174007986	D-loop; other site
563174007987	H-loop/switch region; other site
563174007988	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
563174007989	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
563174007990	Walker A/P-loop; other site
563174007991	ATP binding site [chemical binding]; other site
563174007992	Q-loop/lid; other site
563174007993	ABC transporter signature motif; other site
563174007994	Walker B; other site
563174007995	D-loop; other site
563174007996	H-loop/switch region; other site
563174007997	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
563174007998	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174007999	dimer interface [polypeptide binding]; other site
563174008000	conserved gate region; other site
563174008001	putative PBP binding loops; other site
563174008002	ABC-ATPase subunit interface; other site
563174008003	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
563174008004	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174008005	dimer interface [polypeptide binding]; other site
563174008006	conserved gate region; other site
563174008007	putative PBP binding loops; other site
563174008008	ABC-ATPase subunit interface; other site
563174008009	PBP superfamily domain; Region: PBP_like_2; cl17296
563174008010	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
563174008011	HAMP domain; Region: HAMP; pfam00672
563174008012	dimerization interface [polypeptide binding]; other site
563174008013	PAS domain; Region: PAS; smart00091
563174008014	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
563174008015	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
563174008016	dimer interface [polypeptide binding]; other site
563174008017	phosphorylation site [posttranslational modification]
563174008018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174008019	ATP binding site [chemical binding]; other site
563174008020	Mg2+ binding site [ion binding]; other site
563174008021	G-X-G motif; other site
563174008022	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
563174008023	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174008024	active site
563174008025	phosphorylation site [posttranslational modification]
563174008026	intermolecular recognition site; other site
563174008027	dimerization interface [polypeptide binding]; other site
563174008028	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
563174008029	DNA binding site [nucleotide binding]
563174008030	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
563174008031	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
563174008032	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
563174008033	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
563174008034	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
563174008035	putative active site [active]
563174008036	catalytic site [active]
563174008037	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
563174008038	putative active site [active]
563174008039	catalytic site [active]
563174008040	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
563174008041	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
563174008042	Peptidase family M23; Region: Peptidase_M23; pfam01551
563174008043	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
563174008044	NlpC/P60 family; Region: NLPC_P60; pfam00877
563174008045	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
563174008046	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
563174008047	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
563174008048	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174008049	Walker A/P-loop; other site
563174008050	ATP binding site [chemical binding]; other site
563174008051	Q-loop/lid; other site
563174008052	ABC transporter signature motif; other site
563174008053	Walker B; other site
563174008054	D-loop; other site
563174008055	H-loop/switch region; other site
563174008056	Uncharacterized conserved protein [Function unknown]; Region: COG1284
563174008057	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
563174008058	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
563174008059	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
563174008060	peptide chain release factor 2; Validated; Region: prfB; PRK00578
563174008061	This domain is found in peptide chain release factors; Region: PCRF; smart00937
563174008062	RF-1 domain; Region: RF-1; pfam00472
563174008063	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
563174008064	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
563174008065	nucleotide binding region [chemical binding]; other site
563174008066	helicase superfamily c-terminal domain; Region: HELICc; smart00490
563174008067	ATP-binding site [chemical binding]; other site
563174008068	SEC-C motif; Region: SEC-C; pfam02810
563174008069	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
563174008070	30S subunit binding site; other site
563174008071	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
563174008072	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
563174008073	active site
563174008074	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
563174008075	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
563174008076	ATP binding site [chemical binding]; other site
563174008077	putative Mg++ binding site [ion binding]; other site
563174008078	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
563174008079	nucleotide binding region [chemical binding]; other site
563174008080	ATP-binding site [chemical binding]; other site
563174008081	EDD domain protein, DegV family; Region: DegV; TIGR00762
563174008082	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
563174008083	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
563174008084	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174008085	active site
563174008086	phosphorylation site [posttranslational modification]
563174008087	intermolecular recognition site; other site
563174008088	dimerization interface [polypeptide binding]; other site
563174008089	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
563174008090	DNA binding residues [nucleotide binding]
563174008091	dimerization interface [polypeptide binding]; other site
563174008092	Uncharacterized conserved protein [Function unknown]; Region: COG1739
563174008093	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
563174008094	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
563174008095	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
563174008096	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
563174008097	Transcriptional regulator [Transcription]; Region: LytR; COG1316
563174008098	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
563174008099	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
563174008100	Mg++ binding site [ion binding]; other site
563174008101	putative catalytic motif [active]
563174008102	substrate binding site [chemical binding]; other site
563174008103	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
563174008104	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
563174008105	active site
563174008106	octamer interface [polypeptide binding]; other site
563174008107	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
563174008108	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
563174008109	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
563174008110	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
563174008111	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
563174008112	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
563174008113	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
563174008114	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
563174008115	dimer interface [polypeptide binding]; other site
563174008116	ssDNA binding site [nucleotide binding]; other site
563174008117	tetramer (dimer of dimers) interface [polypeptide binding]; other site
563174008118	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
563174008119	rod shape-determining protein Mbl; Provisional; Region: PRK13928
563174008120	MreB and similar proteins; Region: MreB_like; cd10225
563174008121	nucleotide binding site [chemical binding]; other site
563174008122	Mg binding site [ion binding]; other site
563174008123	putative protofilament interaction site [polypeptide binding]; other site
563174008124	RodZ interaction site [polypeptide binding]; other site
563174008125	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
563174008126	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
563174008127	hinge; other site
563174008128	active site
563174008129	Predicted membrane protein [Function unknown]; Region: COG4836
563174008130	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
563174008131	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
563174008132	gamma subunit interface [polypeptide binding]; other site
563174008133	epsilon subunit interface [polypeptide binding]; other site
563174008134	LBP interface [polypeptide binding]; other site
563174008135	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
563174008136	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
563174008137	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
563174008138	alpha subunit interaction interface [polypeptide binding]; other site
563174008139	Walker A motif; other site
563174008140	ATP binding site [chemical binding]; other site
563174008141	Walker B motif; other site
563174008142	inhibitor binding site; inhibition site
563174008143	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
563174008144	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
563174008145	core domain interface [polypeptide binding]; other site
563174008146	delta subunit interface [polypeptide binding]; other site
563174008147	epsilon subunit interface [polypeptide binding]; other site
563174008148	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
563174008149	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
563174008150	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
563174008151	beta subunit interaction interface [polypeptide binding]; other site
563174008152	Walker A motif; other site
563174008153	ATP binding site [chemical binding]; other site
563174008154	Walker B motif; other site
563174008155	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
563174008156	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
563174008157	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
563174008158	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
563174008159	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
563174008160	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
563174008161	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
563174008162	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
563174008163	ATP synthase I chain; Region: ATP_synt_I; pfam03899
563174008164	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
563174008165	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
563174008166	active site
563174008167	homodimer interface [polypeptide binding]; other site
563174008168	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
563174008169	active site
563174008170	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
563174008171	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
563174008172	dimer interface [polypeptide binding]; other site
563174008173	active site
563174008174	glycine-pyridoxal phosphate binding site [chemical binding]; other site
563174008175	folate binding site [chemical binding]; other site
563174008176	Low molecular weight phosphatase family; Region: LMWPc; cd00115
563174008177	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
563174008178	active site
563174008179	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
563174008180	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
563174008181	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
563174008182	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174008183	S-adenosylmethionine binding site [chemical binding]; other site
563174008184	peptide chain release factor 1; Validated; Region: prfA; PRK00591
563174008185	This domain is found in peptide chain release factors; Region: PCRF; smart00937
563174008186	RF-1 domain; Region: RF-1; pfam00472
563174008187	thymidine kinase; Provisional; Region: PRK04296
563174008188	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
563174008189	ATP binding site [chemical binding]; other site
563174008190	Walker A motif; other site
563174008191	Walker B motif; other site
563174008192	homoserine kinase; Provisional; Region: PRK01212
563174008193	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
563174008194	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
563174008195	threonine synthase; Reviewed; Region: PRK06721
563174008196	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
563174008197	homodimer interface [polypeptide binding]; other site
563174008198	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174008199	catalytic residue [active]
563174008200	homoserine dehydrogenase; Provisional; Region: PRK06349
563174008201	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
563174008202	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
563174008203	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
563174008204	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
563174008205	Predicted membrane protein [Function unknown]; Region: COG2246
563174008206	GtrA-like protein; Region: GtrA; pfam04138
563174008207	transcription termination factor Rho; Provisional; Region: rho; PRK09376
563174008208	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
563174008209	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
563174008210	RNA binding site [nucleotide binding]; other site
563174008211	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
563174008212	multimer interface [polypeptide binding]; other site
563174008213	Walker A motif; other site
563174008214	ATP binding site [chemical binding]; other site
563174008215	Walker B motif; other site
563174008216	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
563174008217	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
563174008218	hinge; other site
563174008219	active site
563174008220	Predicted integral membrane protein [Function unknown]; Region: COG0392
563174008221	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
563174008222	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
563174008223	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
563174008224	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
563174008225	putative ADP-binding pocket [chemical binding]; other site
563174008226	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
563174008227	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
563174008228	intersubunit interface [polypeptide binding]; other site
563174008229	active site
563174008230	zinc binding site [ion binding]; other site
563174008231	Na+ binding site [ion binding]; other site
563174008232	putative lipid kinase; Reviewed; Region: PRK13055
563174008233	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
563174008234	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
563174008235	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
563174008236	amidase catalytic site [active]
563174008237	Zn binding residues [ion binding]; other site
563174008238	substrate binding site [chemical binding]; other site
563174008239	SH3-like domain; Region: SH3_8; pfam13457
563174008240	SH3-like domain; Region: SH3_8; pfam13457
563174008241	SH3-like domain; Region: SH3_8; pfam13457
563174008242	SH3-like domain; Region: SH3_8; pfam13457
563174008243	CTP synthetase; Validated; Region: pyrG; PRK05380
563174008244	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
563174008245	Catalytic site [active]
563174008246	active site
563174008247	UTP binding site [chemical binding]; other site
563174008248	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
563174008249	active site
563174008250	putative oxyanion hole; other site
563174008251	catalytic triad [active]
563174008252	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
563174008253	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
563174008254	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
563174008255	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
563174008256	active site
563174008257	HIGH motif; other site
563174008258	KMSK motif region; other site
563174008259	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
563174008260	tRNA binding surface [nucleotide binding]; other site
563174008261	anticodon binding site; other site
563174008262	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
563174008263	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
563174008264	Peptidase family M50; Region: Peptidase_M50; pfam02163
563174008265	active site
563174008266	putative substrate binding region [chemical binding]; other site
563174008267	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
563174008268	active site 1 [active]
563174008269	dimer interface [polypeptide binding]; other site
563174008270	hexamer interface [polypeptide binding]; other site
563174008271	active site 2 [active]
563174008272	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
563174008273	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
563174008274	Zn2+ binding site [ion binding]; other site
563174008275	Mg2+ binding site [ion binding]; other site
563174008276	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
563174008277	conserved hypothetical protein TIGR01655; Region: yxeA_fam
563174008278	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
563174008279	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
563174008280	peptide binding site [polypeptide binding]; other site
563174008281	Predicted integral membrane protein [Function unknown]; Region: COG5658
563174008282	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
563174008283	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
563174008284	catalytic triad [active]
563174008285	metal binding site [ion binding]; metal-binding site
563174008286	conserved cis-peptide bond; other site
563174008287	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
563174008288	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
563174008289	folate binding site [chemical binding]; other site
563174008290	NADP+ binding site [chemical binding]; other site
563174008291	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
563174008292	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
563174008293	putative NAD(P) binding site [chemical binding]; other site
563174008294	dimer interface [polypeptide binding]; other site
563174008295	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
563174008296	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
563174008297	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
563174008298	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174008299	active site
563174008300	motif I; other site
563174008301	motif II; other site
563174008302	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
563174008303	Uncharacterized conserved protein [Function unknown]; Region: COG1359
563174008304	Leucine rich repeat; Region: LRR_8; pfam13855
563174008305	LRR adjacent; Region: LRR_adjacent; pfam08191
563174008306	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
563174008307	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174008308	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174008309	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174008310	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174008311	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174008312	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174008313	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174008314	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174008315	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
563174008316	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
563174008317	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
563174008318	Walker A/P-loop; other site
563174008319	ATP binding site [chemical binding]; other site
563174008320	Q-loop/lid; other site
563174008321	ABC transporter signature motif; other site
563174008322	Walker B; other site
563174008323	D-loop; other site
563174008324	H-loop/switch region; other site
563174008325	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
563174008326	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
563174008327	FtsX-like permease family; Region: FtsX; pfam02687
563174008328	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
563174008329	dimerization interface [polypeptide binding]; other site
563174008330	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
563174008331	dimer interface [polypeptide binding]; other site
563174008332	phosphorylation site [posttranslational modification]
563174008333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174008334	ATP binding site [chemical binding]; other site
563174008335	Mg2+ binding site [ion binding]; other site
563174008336	G-X-G motif; other site
563174008337	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
563174008338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174008339	active site
563174008340	phosphorylation site [posttranslational modification]
563174008341	intermolecular recognition site; other site
563174008342	dimerization interface [polypeptide binding]; other site
563174008343	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
563174008344	DNA binding site [nucleotide binding]
563174008345	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
563174008346	Uncharacterized conserved protein [Function unknown]; Region: COG2427
563174008347	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
563174008348	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
563174008349	catalytic loop [active]
563174008350	iron binding site [ion binding]; other site
563174008351	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
563174008352	4Fe-4S binding domain; Region: Fer4; pfam00037
563174008353	4Fe-4S binding domain; Region: Fer4; pfam00037
563174008354	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
563174008355	[4Fe-4S] binding site [ion binding]; other site
563174008356	molybdopterin cofactor binding site; other site
563174008357	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
563174008358	molybdopterin cofactor binding site; other site
563174008359	Uncharacterized conserved protein [Function unknown]; Region: COG1912
563174008360	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174008361	putative substrate translocation pore; other site
563174008362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174008363	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
563174008364	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
563174008365	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
563174008366	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
563174008367	Walker A motif; other site
563174008368	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
563174008369	SH3-like domain; Region: SH3_8; pfam13457
563174008370	SH3-like domain; Region: SH3_8; pfam13457
563174008371	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
563174008372	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
563174008373	active site
563174008374	catalytic tetrad [active]
563174008375	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
563174008376	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
563174008377	DNA binding residues [nucleotide binding]
563174008378	putative dimer interface [polypeptide binding]; other site
563174008379	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
563174008380	active site
563174008381	metal binding site [ion binding]; metal-binding site
563174008382	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
563174008383	Bacteriophage holin; Region: Phage_holin_1; pfam04531
563174008384	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
563174008385	putative pectinesterase; Region: PLN02432; cl01911
563174008386	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
563174008387	Phage tail protein; Region: Sipho_tail; pfam05709
563174008388	tape measure domain; Region: tape_meas_nterm; TIGR02675
563174008389	Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854
563174008390	Phage protein Gp14; Region: Phage_Gp14; pfam10666
563174008391	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
563174008392	Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691
563174008393	Minor capsid protein; Region: Minor_capsid_2; pfam11114
563174008394	Minor capsid protein; Region: Minor_capsid_1; pfam10665
563174008395	Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053
563174008396	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
563174008397	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
563174008398	phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542
563174008399	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
563174008400	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
563174008401	Phage terminase large subunit; Region: Terminase_3; cl12054
563174008402	Terminase-like family; Region: Terminase_6; pfam03237
563174008403	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
563174008404	SprT-like family; Region: SprT-like; pfam10263
563174008405	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
563174008406	Protein of unknown function (DUF2481); Region: DUF2481; pfam10654
563174008407	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
563174008408	NUMOD4 motif; Region: NUMOD4; pfam07463
563174008409	HNH endonuclease; Region: HNH_3; pfam13392
563174008410	NUMOD1 domain; Region: NUMOD1; pfam07453
563174008411	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
563174008412	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
563174008413	dimer interface [polypeptide binding]; other site
563174008414	ssDNA binding site [nucleotide binding]; other site
563174008415	tetramer (dimer of dimers) interface [polypeptide binding]; other site
563174008416	Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961
563174008417	chaperone protein DnaJ; Provisional; Region: PRK14291
563174008418	YopX protein; Region: YopX; cl09859
563174008419	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
563174008420	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
563174008421	cofactor binding site; other site
563174008422	DNA binding site [nucleotide binding]
563174008423	substrate interaction site [chemical binding]; other site
563174008424	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
563174008425	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
563174008426	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
563174008427	Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723
563174008428	Phage-related protein, predicted endonuclease [DNA replication, recombination, and repair]; Region: COG5377
563174008429	Protein gp45 of Bacteriophage A118; Region: Phage-A118_gp45; pfam10653
563174008430	AntA/AntB antirepressor; Region: AntA; pfam08346
563174008431	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
563174008432	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174008433	non-specific DNA binding site [nucleotide binding]; other site
563174008434	salt bridge; other site
563174008435	sequence-specific DNA binding site [nucleotide binding]; other site
563174008436	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
563174008437	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174008438	sequence-specific DNA binding site [nucleotide binding]; other site
563174008439	salt bridge; other site
563174008440	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
563174008441	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
563174008442	Int/Topo IB signature motif; other site
563174008443	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
563174008444	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
563174008445	23S rRNA interface [nucleotide binding]; other site
563174008446	L3 interface [polypeptide binding]; other site
563174008447	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
563174008448	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
563174008449	dimerization interface 3.5A [polypeptide binding]; other site
563174008450	active site
563174008451	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
563174008452	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
563174008453	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
563174008454	Walker A/P-loop; other site
563174008455	ATP binding site [chemical binding]; other site
563174008456	Q-loop/lid; other site
563174008457	ABC transporter signature motif; other site
563174008458	Walker B; other site
563174008459	D-loop; other site
563174008460	H-loop/switch region; other site
563174008461	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
563174008462	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
563174008463	Walker A/P-loop; other site
563174008464	ATP binding site [chemical binding]; other site
563174008465	Q-loop/lid; other site
563174008466	ABC transporter signature motif; other site
563174008467	Walker B; other site
563174008468	D-loop; other site
563174008469	H-loop/switch region; other site
563174008470	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
563174008471	MgtC family; Region: MgtC; pfam02308
563174008472	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
563174008473	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
563174008474	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
563174008475	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
563174008476	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
563174008477	alphaNTD - beta interaction site [polypeptide binding]; other site
563174008478	alphaNTD homodimer interface [polypeptide binding]; other site
563174008479	alphaNTD - beta' interaction site [polypeptide binding]; other site
563174008480	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
563174008481	30S ribosomal protein S11; Validated; Region: PRK05309
563174008482	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
563174008483	30S ribosomal protein S13; Region: bact_S13; TIGR03631
563174008484	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
563174008485	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
563174008486	rRNA binding site [nucleotide binding]; other site
563174008487	predicted 30S ribosome binding site; other site
563174008488	adenylate kinase; Reviewed; Region: adk; PRK00279
563174008489	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
563174008490	AMP-binding site [chemical binding]; other site
563174008491	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
563174008492	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
563174008493	SecY translocase; Region: SecY; pfam00344
563174008494	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
563174008495	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
563174008496	23S rRNA binding site [nucleotide binding]; other site
563174008497	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
563174008498	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
563174008499	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
563174008500	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
563174008501	5S rRNA interface [nucleotide binding]; other site
563174008502	L27 interface [polypeptide binding]; other site
563174008503	23S rRNA interface [nucleotide binding]; other site
563174008504	L5 interface [polypeptide binding]; other site
563174008505	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
563174008506	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
563174008507	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
563174008508	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
563174008509	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
563174008510	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
563174008511	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
563174008512	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
563174008513	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
563174008514	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
563174008515	RNA binding site [nucleotide binding]; other site
563174008516	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
563174008517	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
563174008518	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
563174008519	23S rRNA interface [nucleotide binding]; other site
563174008520	putative translocon interaction site; other site
563174008521	signal recognition particle (SRP54) interaction site; other site
563174008522	L23 interface [polypeptide binding]; other site
563174008523	trigger factor interaction site; other site
563174008524	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
563174008525	23S rRNA interface [nucleotide binding]; other site
563174008526	5S rRNA interface [nucleotide binding]; other site
563174008527	putative antibiotic binding site [chemical binding]; other site
563174008528	L25 interface [polypeptide binding]; other site
563174008529	L27 interface [polypeptide binding]; other site
563174008530	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
563174008531	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
563174008532	G-X-X-G motif; other site
563174008533	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
563174008534	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
563174008535	putative translocon binding site; other site
563174008536	protein-rRNA interface [nucleotide binding]; other site
563174008537	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
563174008538	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
563174008539	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
563174008540	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
563174008541	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
563174008542	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
563174008543	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
563174008544	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
563174008545	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
563174008546	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387
563174008547	UbiA prenyltransferase family; Region: UbiA; pfam01040
563174008548	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
563174008549	ApbE family; Region: ApbE; pfam02424
563174008550	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
563174008551	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
563174008552	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
563174008553	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
563174008554	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
563174008555	Predicted membrane protein [Function unknown]; Region: COG2259
563174008556	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
563174008557	trimer interface [polypeptide binding]; other site
563174008558	Predicted membrane protein [Function unknown]; Region: COG4769
563174008559	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
563174008560	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
563174008561	substrate binding pocket [chemical binding]; other site
563174008562	chain length determination region; other site
563174008563	substrate-Mg2+ binding site; other site
563174008564	catalytic residues [active]
563174008565	aspartate-rich region 1; other site
563174008566	active site lid residues [active]
563174008567	aspartate-rich region 2; other site
563174008568	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
563174008569	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
563174008570	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
563174008571	active site
563174008572	metal binding site [ion binding]; metal-binding site
563174008573	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
563174008574	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
563174008575	hypothetical protein; Provisional; Region: PRK02947
563174008576	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
563174008577	putative active site [active]
563174008578	Protein of unknown function (DUF1341); Region: DUF1341; cl06211
563174008579	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
563174008580	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
563174008581	active site
563174008582	substrate binding pocket [chemical binding]; other site
563174008583	homodimer interaction site [polypeptide binding]; other site
563174008584	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
563174008585	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
563174008586	active site
563174008587	P-loop; other site
563174008588	phosphorylation site [posttranslational modification]
563174008589	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174008590	active site
563174008591	phosphorylation site [posttranslational modification]
563174008592	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
563174008593	Mga helix-turn-helix domain; Region: Mga; pfam05043
563174008594	PRD domain; Region: PRD; pfam00874
563174008595	PRD domain; Region: PRD; pfam00874
563174008596	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
563174008597	active site
563174008598	P-loop; other site
563174008599	phosphorylation site [posttranslational modification]
563174008600	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174008601	active site
563174008602	phosphorylation site [posttranslational modification]
563174008603	elongation factor Tu; Reviewed; Region: PRK00049
563174008604	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
563174008605	G1 box; other site
563174008606	GEF interaction site [polypeptide binding]; other site
563174008607	GTP/Mg2+ binding site [chemical binding]; other site
563174008608	Switch I region; other site
563174008609	G2 box; other site
563174008610	G3 box; other site
563174008611	Switch II region; other site
563174008612	G4 box; other site
563174008613	G5 box; other site
563174008614	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
563174008615	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
563174008616	Antibiotic Binding Site [chemical binding]; other site
563174008617	elongation factor G; Reviewed; Region: PRK00007
563174008618	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
563174008619	G1 box; other site
563174008620	putative GEF interaction site [polypeptide binding]; other site
563174008621	GTP/Mg2+ binding site [chemical binding]; other site
563174008622	Switch I region; other site
563174008623	G2 box; other site
563174008624	G3 box; other site
563174008625	Switch II region; other site
563174008626	G4 box; other site
563174008627	G5 box; other site
563174008628	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
563174008629	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
563174008630	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
563174008631	30S ribosomal protein S7; Validated; Region: PRK05302
563174008632	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
563174008633	S17 interaction site [polypeptide binding]; other site
563174008634	S8 interaction site; other site
563174008635	16S rRNA interaction site [nucleotide binding]; other site
563174008636	streptomycin interaction site [chemical binding]; other site
563174008637	23S rRNA interaction site [nucleotide binding]; other site
563174008638	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
563174008639	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
563174008640	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
563174008641	Zn2+ binding site [ion binding]; other site
563174008642	Mg2+ binding site [ion binding]; other site
563174008643	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
563174008644	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174008645	Coenzyme A binding pocket [chemical binding]; other site
563174008646	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
563174008647	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
563174008648	substrate binding site [chemical binding]; other site
563174008649	hexamer interface [polypeptide binding]; other site
563174008650	metal binding site [ion binding]; metal-binding site
563174008651	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
563174008652	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
563174008653	TPP-binding site [chemical binding]; other site
563174008654	dimer interface [polypeptide binding]; other site
563174008655	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
563174008656	PYR/PP interface [polypeptide binding]; other site
563174008657	dimer interface [polypeptide binding]; other site
563174008658	TPP binding site [chemical binding]; other site
563174008659	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
563174008660	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
563174008661	substrate binding site [chemical binding]; other site
563174008662	hexamer interface [polypeptide binding]; other site
563174008663	metal binding site [ion binding]; metal-binding site
563174008664	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
563174008665	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
563174008666	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
563174008667	putative NAD(P) binding site [chemical binding]; other site
563174008668	catalytic Zn binding site [ion binding]; other site
563174008669	structural Zn binding site [ion binding]; other site
563174008670	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
563174008671	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
563174008672	putative NAD(P) binding site [chemical binding]; other site
563174008673	catalytic Zn binding site [ion binding]; other site
563174008674	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
563174008675	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
563174008676	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
563174008677	active site
563174008678	P-loop; other site
563174008679	phosphorylation site [posttranslational modification]
563174008680	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174008681	active site
563174008682	phosphorylation site [posttranslational modification]
563174008683	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
563174008684	PRD domain; Region: PRD; pfam00874
563174008685	PRD domain; Region: PRD; pfam00874
563174008686	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
563174008687	active site
563174008688	P-loop; other site
563174008689	phosphorylation site [posttranslational modification]
563174008690	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174008691	active site
563174008692	phosphorylation site [posttranslational modification]
563174008693	Predicted membrane protein [Function unknown]; Region: COG4905
563174008694	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
563174008695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
563174008696	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
563174008697	Ligand Binding Site [chemical binding]; other site
563174008698	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
563174008699	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
563174008700	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
563174008701	active site
563174008702	DNA binding site [nucleotide binding]
563174008703	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
563174008704	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
563174008705	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
563174008706	active site
563174008707	phosphorylation site [posttranslational modification]
563174008708	intermolecular recognition site; other site
563174008709	dimerization interface [polypeptide binding]; other site
563174008710	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
563174008711	DNA binding site [nucleotide binding]
563174008712	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
563174008713	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
563174008714	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
563174008715	Ligand Binding Site [chemical binding]; other site
563174008716	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
563174008717	GAF domain; Region: GAF_3; pfam13492
563174008718	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
563174008719	dimer interface [polypeptide binding]; other site
563174008720	phosphorylation site [posttranslational modification]
563174008721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563174008722	ATP binding site [chemical binding]; other site
563174008723	Mg2+ binding site [ion binding]; other site
563174008724	G-X-G motif; other site
563174008725	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
563174008726	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
563174008727	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
563174008728	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
563174008729	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
563174008730	active site
563174008731	P-loop; other site
563174008732	phosphorylation site [posttranslational modification]
563174008733	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
563174008734	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
563174008735	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
563174008736	methionine cluster; other site
563174008737	active site
563174008738	phosphorylation site [posttranslational modification]
563174008739	metal binding site [ion binding]; metal-binding site
563174008740	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
563174008741	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
563174008742	magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524
563174008743	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
563174008744	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
563174008745	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
563174008746	Soluble P-type ATPase [General function prediction only]; Region: COG4087
563174008747	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
563174008748	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
563174008749	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
563174008750	autolysin; Reviewed; Region: PRK06347
563174008751	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
563174008752	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
563174008753	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
563174008754	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
563174008755	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
563174008756	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174008757	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
563174008758	Walker A motif; other site
563174008759	ATP binding site [chemical binding]; other site
563174008760	Walker B motif; other site
563174008761	arginine finger; other site
563174008762	Protein of unknown function (DUF970); Region: DUF970; pfam06153
563174008763	thymidylate kinase; Validated; Region: tmk; PRK00698
563174008764	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
563174008765	TMP-binding site; other site
563174008766	ATP-binding site [chemical binding]; other site
563174008767	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
563174008768	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
563174008769	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
563174008770	catalytic residue [active]
563174008771	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
563174008772	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
563174008773	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
563174008774	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
563174008775	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
563174008776	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
563174008777	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
563174008778	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
563174008779	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
563174008780	putative active site [active]
563174008781	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
563174008782	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174008783	active site
563174008784	motif I; other site
563174008785	motif II; other site
563174008786	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
563174008787	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
563174008788	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
563174008789	active site
563174008790	catalytic tetrad [active]
563174008791	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
563174008792	recombination protein RecR; Reviewed; Region: recR; PRK00076
563174008793	RecR protein; Region: RecR; pfam02132
563174008794	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
563174008795	putative active site [active]
563174008796	putative metal-binding site [ion binding]; other site
563174008797	tetramer interface [polypeptide binding]; other site
563174008798	hypothetical protein; Validated; Region: PRK00153
563174008799	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
563174008800	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563174008801	Walker A motif; other site
563174008802	ATP binding site [chemical binding]; other site
563174008803	Walker B motif; other site
563174008804	arginine finger; other site
563174008805	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
563174008806	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
563174008807	Protein of unknown function (DUF3188); Region: DUF3188; pfam11384
563174008808	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
563174008809	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
563174008810	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
563174008811	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
563174008812	N- and C-terminal domain interface [polypeptide binding]; other site
563174008813	active site
563174008814	catalytic site [active]
563174008815	metal binding site [ion binding]; metal-binding site
563174008816	carbohydrate binding site [chemical binding]; other site
563174008817	ATP binding site [chemical binding]; other site
563174008818	SH3-like domain; Region: SH3_8; pfam13457
563174008819	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
563174008820	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
563174008821	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
563174008822	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
563174008823	Walker A/P-loop; other site
563174008824	ATP binding site [chemical binding]; other site
563174008825	Q-loop/lid; other site
563174008826	ABC transporter signature motif; other site
563174008827	Walker B; other site
563174008828	D-loop; other site
563174008829	H-loop/switch region; other site
563174008830	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
563174008831	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
563174008832	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174008833	Walker A/P-loop; other site
563174008834	ATP binding site [chemical binding]; other site
563174008835	Q-loop/lid; other site
563174008836	ABC transporter signature motif; other site
563174008837	Walker B; other site
563174008838	D-loop; other site
563174008839	H-loop/switch region; other site
563174008840	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
563174008841	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
563174008842	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
563174008843	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
563174008844	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
563174008845	nucleoside/Zn binding site; other site
563174008846	dimer interface [polypeptide binding]; other site
563174008847	catalytic motif [active]
563174008848	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
563174008849	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
563174008850	active site
563174008851	acyl-activating enzyme (AAE) consensus motif; other site
563174008852	putative CoA binding site [chemical binding]; other site
563174008853	AMP binding site [chemical binding]; other site
563174008854	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
563174008855	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
563174008856	active site
563174008857	trimer interface [polypeptide binding]; other site
563174008858	allosteric site; other site
563174008859	active site lid [active]
563174008860	hexamer (dimer of trimers) interface [polypeptide binding]; other site
563174008861	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
563174008862	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
563174008863	DNA binding residues [nucleotide binding]
563174008864	drug binding residues [chemical binding]; other site
563174008865	dimer interface [polypeptide binding]; other site
563174008866	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
563174008867	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174008868	Coenzyme A binding pocket [chemical binding]; other site
563174008869	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
563174008870	dimer interface [polypeptide binding]; other site
563174008871	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
563174008872	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
563174008873	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
563174008874	MarR family; Region: MarR; pfam01047
563174008875	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
563174008876	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
563174008877	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
563174008878	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
563174008879	DNA binding residues [nucleotide binding]
563174008880	putative dimer interface [polypeptide binding]; other site
563174008881	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
563174008882	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
563174008883	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174008884	active site
563174008885	motif I; other site
563174008886	motif II; other site
563174008887	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
563174008888	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
563174008889	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
563174008890	putative active site [active]
563174008891	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
563174008892	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174008893	active site
563174008894	phosphorylation site [posttranslational modification]
563174008895	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
563174008896	active site
563174008897	P-loop; other site
563174008898	phosphorylation site [posttranslational modification]
563174008899	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
563174008900	alpha-mannosidase; Provisional; Region: PRK09819
563174008901	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
563174008902	active site
563174008903	metal binding site [ion binding]; metal-binding site
563174008904	catalytic site [active]
563174008905	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
563174008906	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
563174008907	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
563174008908	active site
563174008909	homodimer interface [polypeptide binding]; other site
563174008910	catalytic site [active]
563174008911	glycerate kinase; Region: TIGR00045
563174008912	Transcriptional regulators [Transcription]; Region: PurR; COG1609
563174008913	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
563174008914	DNA binding site [nucleotide binding]
563174008915	domain linker motif; other site
563174008916	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
563174008917	putative dimerization interface [polypeptide binding]; other site
563174008918	putative ligand binding site [chemical binding]; other site
563174008919	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
563174008920	Domain of unknown function DUF21; Region: DUF21; pfam01595
563174008921	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
563174008922	Transporter associated domain; Region: CorC_HlyC; pfam03471
563174008923	NAD-dependent deacetylase; Provisional; Region: PRK00481
563174008924	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
563174008925	NAD+ binding site [chemical binding]; other site
563174008926	substrate binding site [chemical binding]; other site
563174008927	putative Zn binding site [ion binding]; other site
563174008928	Pathogenicity locus; Region: Cdd1; pfam11731
563174008929	drug efflux system protein MdtG; Provisional; Region: PRK09874
563174008930	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174008931	putative substrate translocation pore; other site
563174008932	Variant SH3 domain; Region: SH3_2; pfam07653
563174008933	Variant SH3 domain; Region: SH3_2; pfam07653
563174008934	peptide ligand binding site [polypeptide binding]; other site
563174008935	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
563174008936	active site
563174008937	intersubunit interactions; other site
563174008938	catalytic residue [active]
563174008939	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
563174008940	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
563174008941	ligand binding site [chemical binding]; other site
563174008942	flexible hinge region; other site
563174008943	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
563174008944	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
563174008945	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
563174008946	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174008947	Walker A/P-loop; other site
563174008948	ATP binding site [chemical binding]; other site
563174008949	Q-loop/lid; other site
563174008950	ABC transporter signature motif; other site
563174008951	Walker B; other site
563174008952	D-loop; other site
563174008953	H-loop/switch region; other site
563174008954	TfoX C-terminal domain; Region: TfoX_C; pfam04994
563174008955	seryl-tRNA synthetase; Provisional; Region: PRK05431
563174008956	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
563174008957	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
563174008958	dimer interface [polypeptide binding]; other site
563174008959	active site
563174008960	motif 1; other site
563174008961	motif 2; other site
563174008962	motif 3; other site
563174008963	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
563174008964	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
563174008965	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
563174008966	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
563174008967	glutamine binding [chemical binding]; other site
563174008968	catalytic triad [active]
563174008969	aminodeoxychorismate synthase; Provisional; Region: PRK07508
563174008970	chorismate binding enzyme; Region: Chorismate_bind; cl10555
563174008971	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
563174008972	substrate-cofactor binding pocket; other site
563174008973	homodimer interface [polypeptide binding]; other site
563174008974	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
563174008975	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563174008976	catalytic residue [active]
563174008977	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
563174008978	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
563174008979	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174008980	Walker A/P-loop; other site
563174008981	ATP binding site [chemical binding]; other site
563174008982	Q-loop/lid; other site
563174008983	ABC transporter signature motif; other site
563174008984	Walker B; other site
563174008985	D-loop; other site
563174008986	H-loop/switch region; other site
563174008987	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
563174008988	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
563174008989	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563174008990	Walker A/P-loop; other site
563174008991	ATP binding site [chemical binding]; other site
563174008992	Q-loop/lid; other site
563174008993	ABC transporter signature motif; other site
563174008994	Walker B; other site
563174008995	D-loop; other site
563174008996	H-loop/switch region; other site
563174008997	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
563174008998	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
563174008999	RHS Repeat; Region: RHS_repeat; pfam05593
563174009000	RHS Repeat; Region: RHS_repeat; pfam05593
563174009001	RHS Repeat; Region: RHS_repeat; pfam05593
563174009002	RHS Repeat; Region: RHS_repeat; pfam05593
563174009003	RHS Repeat; Region: RHS_repeat; pfam05593
563174009004	RHS Repeat; Region: RHS_repeat; pfam05593
563174009005	RHS Repeat; Region: RHS_repeat; pfam05593
563174009006	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
563174009007	RHS Repeat; Region: RHS_repeat; pfam05593
563174009008	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
563174009009	RHS Repeat; Region: RHS_repeat; pfam05593
563174009010	RHS Repeat; Region: RHS_repeat; pfam05593
563174009011	RHS Repeat; Region: RHS_repeat; cl11982
563174009012	RHS Repeat; Region: RHS_repeat; pfam05593
563174009013	RHS Repeat; Region: RHS_repeat; pfam05593
563174009014	RHS Repeat; Region: RHS_repeat; pfam05593
563174009015	RHS Repeat; Region: RHS_repeat; pfam05593
563174009016	RHS Repeat; Region: RHS_repeat; pfam05593
563174009017	RHS Repeat; Region: RHS_repeat; pfam05593
563174009018	RHS Repeat; Region: RHS_repeat; pfam05593
563174009019	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
563174009020	RHS Repeat; Region: RHS_repeat; pfam05593
563174009021	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
563174009022	RHS Repeat; Region: RHS_repeat; pfam05593
563174009023	RHS Repeat; Region: RHS_repeat; pfam05593
563174009024	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
563174009025	RHS Repeat; Region: RHS_repeat; pfam05593
563174009026	RHS Repeat; Region: RHS_repeat; pfam05593
563174009027	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
563174009028	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
563174009029	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
563174009030	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
563174009031	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
563174009032	Predicted acyl esterases [General function prediction only]; Region: COG2936
563174009033	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
563174009034	DNA topoisomerase III; Provisional; Region: PRK07726
563174009035	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
563174009036	active site
563174009037	putative interdomain interaction site [polypeptide binding]; other site
563174009038	putative metal-binding site [ion binding]; other site
563174009039	putative nucleotide binding site [chemical binding]; other site
563174009040	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
563174009041	domain I; other site
563174009042	DNA binding groove [nucleotide binding]
563174009043	phosphate binding site [ion binding]; other site
563174009044	domain II; other site
563174009045	domain III; other site
563174009046	nucleotide binding site [chemical binding]; other site
563174009047	catalytic site [active]
563174009048	domain IV; other site
563174009049	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
563174009050	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
563174009051	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
563174009052	ATP binding site [chemical binding]; other site
563174009053	putative Mg++ binding site [ion binding]; other site
563174009054	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
563174009055	nucleotide binding region [chemical binding]; other site
563174009056	ATP-binding site [chemical binding]; other site
563174009057	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
563174009058	HRDC domain; Region: HRDC; pfam00570
563174009059	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
563174009060	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
563174009061	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
563174009062	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
563174009063	active site
563174009064	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
563174009065	putative ADP-ribose binding site [chemical binding]; other site
563174009066	putative active site [active]
563174009067	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
563174009068	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
563174009069	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
563174009070	ABC transporter; Region: ABC_tran_2; pfam12848
563174009071	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
563174009072	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
563174009073	beta-galactosidase; Region: BGL; TIGR03356
563174009074	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
563174009075	active site
563174009076	P-loop; other site
563174009077	phosphorylation site [posttranslational modification]
563174009078	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
563174009079	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
563174009080	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
563174009081	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
563174009082	nucleotide binding site [chemical binding]; other site
563174009083	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
563174009084	methionine cluster; other site
563174009085	active site
563174009086	phosphorylation site [posttranslational modification]
563174009087	metal binding site [ion binding]; metal-binding site
563174009088	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
563174009089	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
563174009090	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
563174009091	putative active site [active]
563174009092	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
563174009093	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
563174009094	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
563174009095	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
563174009096	Walker A/P-loop; other site
563174009097	ATP binding site [chemical binding]; other site
563174009098	Q-loop/lid; other site
563174009099	ABC transporter signature motif; other site
563174009100	Walker B; other site
563174009101	D-loop; other site
563174009102	H-loop/switch region; other site
563174009103	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
563174009104	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
563174009105	ATP-grasp domain; Region: ATP-grasp_4; cl17255
563174009106	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
563174009107	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
563174009108	Walker A/P-loop; other site
563174009109	ATP binding site [chemical binding]; other site
563174009110	Q-loop/lid; other site
563174009111	ABC transporter signature motif; other site
563174009112	Walker B; other site
563174009113	D-loop; other site
563174009114	H-loop/switch region; other site
563174009115	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
563174009116	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
563174009117	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
563174009118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174009119	putative substrate translocation pore; other site
563174009120	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
563174009121	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
563174009122	GTP-binding protein YchF; Reviewed; Region: PRK09601
563174009123	YchF GTPase; Region: YchF; cd01900
563174009124	G1 box; other site
563174009125	GTP/Mg2+ binding site [chemical binding]; other site
563174009126	Switch I region; other site
563174009127	G2 box; other site
563174009128	Switch II region; other site
563174009129	G3 box; other site
563174009130	G4 box; other site
563174009131	G5 box; other site
563174009132	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
563174009133	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
563174009134	methionine cluster; other site
563174009135	active site
563174009136	phosphorylation site [posttranslational modification]
563174009137	metal binding site [ion binding]; metal-binding site
563174009138	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
563174009139	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
563174009140	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
563174009141	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
563174009142	active site
563174009143	P-loop; other site
563174009144	phosphorylation site [posttranslational modification]
563174009145	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
563174009146	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
563174009147	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
563174009148	HTH domain; Region: HTH_11; pfam08279
563174009149	Mga helix-turn-helix domain; Region: Mga; pfam05043
563174009150	PRD domain; Region: PRD; pfam00874
563174009151	PRD domain; Region: PRD; pfam00874
563174009152	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
563174009153	active site
563174009154	P-loop; other site
563174009155	phosphorylation site [posttranslational modification]
563174009156	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174009157	active site
563174009158	phosphorylation site [posttranslational modification]
563174009159	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
563174009160	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
563174009161	tetramer interface [polypeptide binding]; other site
563174009162	heme binding pocket [chemical binding]; other site
563174009163	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481
563174009164	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
563174009165	ParB-like nuclease domain; Region: ParB; smart00470
563174009166	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
563174009167	salt bridge; other site
563174009168	non-specific DNA binding site [nucleotide binding]; other site
563174009169	sequence-specific DNA binding site [nucleotide binding]; other site
563174009170	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
563174009171	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
563174009172	P-loop; other site
563174009173	Magnesium ion binding site [ion binding]; other site
563174009174	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
563174009175	Magnesium ion binding site [ion binding]; other site
563174009176	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
563174009177	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
563174009178	non-specific DNA binding site [nucleotide binding]; other site
563174009179	salt bridge; other site
563174009180	sequence-specific DNA binding site [nucleotide binding]; other site
563174009181	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
563174009182	ParB-like nuclease domain; Region: ParBc; pfam02195
563174009183	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
563174009184	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
563174009185	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
563174009186	putative active site [active]
563174009187	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
563174009188	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
563174009189	nucleotide binding site [chemical binding]; other site
563174009190	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563174009191	active site
563174009192	phosphorylation site [posttranslational modification]
563174009193	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
563174009194	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174009195	motif II; other site
563174009196	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
563174009197	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
563174009198	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
563174009199	active site
563174009200	P-loop; other site
563174009201	phosphorylation site [posttranslational modification]
563174009202	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
563174009203	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
563174009204	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
563174009205	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
563174009206	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
563174009207	putative active site cavity [active]
563174009208	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
563174009209	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563174009210	S-adenosylmethionine binding site [chemical binding]; other site
563174009211	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
563174009212	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
563174009213	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
563174009214	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
563174009215	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
563174009216	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
563174009217	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
563174009218	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
563174009219	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
563174009220	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
563174009221	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
563174009222	trmE is a tRNA modification GTPase; Region: trmE; cd04164
563174009223	G1 box; other site
563174009224	GTP/Mg2+ binding site [chemical binding]; other site
563174009225	Switch I region; other site
563174009226	G2 box; other site
563174009227	Switch II region; other site
563174009228	G3 box; other site
563174009229	G4 box; other site
563174009230	G5 box; other site
563174009231	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
563174009232	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
563174009233	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
563174009234	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
563174009235	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
563174009236	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
563174009237	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
563174009238	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
563174009239	NADP binding site [chemical binding]; other site
563174009240	homodimer interface [polypeptide binding]; other site
563174009241	active site
563174009242	substrate binding site [chemical binding]; other site
563174009243	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174009244	D-galactonate transporter; Region: 2A0114; TIGR00893
563174009245	putative substrate translocation pore; other site
563174009246	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
563174009247	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
563174009248	metal binding site [ion binding]; metal-binding site
563174009249	dimer interface [polypeptide binding]; other site
563174009250	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
563174009251	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
563174009252	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
563174009253	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
563174009254	metal binding site [ion binding]; metal-binding site
563174009255	dimer interface [polypeptide binding]; other site
563174009256	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
563174009257	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
563174009258	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
563174009259	Abi-like protein; Region: Abi_2; pfam07751
563174009260	Uncharacterized conserved protein [Function unknown]; Region: COG4198
563174009261	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
563174009262	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
563174009263	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
563174009264	putative ligand binding site [chemical binding]; other site
563174009265	putative NAD binding site [chemical binding]; other site
563174009266	putative catalytic site [active]
563174009267	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
563174009268	L-serine binding site [chemical binding]; other site
563174009269	ACT domain interface; other site
563174009270	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
563174009271	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
563174009272	catalytic residue [active]
563174009273	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174009274	Major Facilitator Superfamily; Region: MFS_1; pfam07690
563174009275	putative substrate translocation pore; other site
563174009276	Transcriptional regulators [Transcription]; Region: MarR; COG1846
563174009277	MarR family; Region: MarR_2; pfam12802
563174009278	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
563174009279	dimer interface [polypeptide binding]; other site
563174009280	FMN binding site [chemical binding]; other site
563174009281	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
563174009282	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
563174009283	catalytic residues [active]
563174009284	beta-phosphoglucomutase; Region: bPGM; TIGR01990
563174009285	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
563174009286	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563174009287	motif II; other site
563174009288	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
563174009289	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
563174009290	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
563174009291	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
563174009292	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
563174009293	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
563174009294	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
563174009295	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
563174009296	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
563174009297	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
563174009298	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
563174009299	putative NAD(P) binding site [chemical binding]; other site
563174009300	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
563174009301	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174009302	dimer interface [polypeptide binding]; other site
563174009303	conserved gate region; other site
563174009304	putative PBP binding loops; other site
563174009305	ABC-ATPase subunit interface; other site
563174009306	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
563174009307	dimer interface [polypeptide binding]; other site
563174009308	conserved gate region; other site
563174009309	putative PBP binding loops; other site
563174009310	ABC-ATPase subunit interface; other site
563174009311	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
563174009312	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
563174009313	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
563174009314	sucrose phosphorylase; Provisional; Region: PRK13840
563174009315	active site
563174009316	homodimer interface [polypeptide binding]; other site
563174009317	catalytic site [active]
563174009318	Transcriptional regulators [Transcription]; Region: PurR; COG1609
563174009319	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
563174009320	DNA binding site [nucleotide binding]
563174009321	domain linker motif; other site
563174009322	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
563174009323	putative dimerization interface [polypeptide binding]; other site
563174009324	putative ligand binding site [chemical binding]; other site
563174009325	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
563174009326	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
563174009327	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563174009328	Coenzyme A binding pocket [chemical binding]; other site
563174009329	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174009330	Major Facilitator Superfamily; Region: MFS_1; pfam07690
563174009331	putative substrate translocation pore; other site
563174009332	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174009333	Domain of unknown function (DUF718); Region: DUF718; cl01281
563174009334	rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624
563174009335	intersubunit interface [polypeptide binding]; other site
563174009336	active site
563174009337	Zn2+ binding site [ion binding]; other site
563174009338	L-rhamnose isomerase; Provisional; Region: PRK01076
563174009339	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
563174009340	N- and C-terminal domain interface [polypeptide binding]; other site
563174009341	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
563174009342	active site
563174009343	putative catalytic site [active]
563174009344	metal binding site [ion binding]; metal-binding site
563174009345	ATP binding site [chemical binding]; other site
563174009346	carbohydrate binding site [chemical binding]; other site
563174009347	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563174009348	putative substrate translocation pore; other site
563174009349	Major Facilitator Superfamily; Region: MFS_1; pfam07690
563174009350	Cupin domain; Region: Cupin_2; pfam07883
563174009351	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
563174009352	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
563174009353	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
563174009354	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
563174009355	G-X-X-G motif; other site
563174009356	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
563174009357	RxxxH motif; other site
563174009358	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
563174009359	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
563174009360	ribonuclease P; Reviewed; Region: rnpA; PRK00499
563174009361	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399