-- dump date 20140619_133925 -- class Genbank::misc_feature -- table misc_feature_note -- id note 265669000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 265669000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 265669000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669000004 Walker A motif; other site 265669000005 ATP binding site [chemical binding]; other site 265669000006 Walker B motif; other site 265669000007 arginine finger; other site 265669000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 265669000009 DnaA box-binding interface [nucleotide binding]; other site 265669000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 265669000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 265669000012 putative DNA binding surface [nucleotide binding]; other site 265669000013 dimer interface [polypeptide binding]; other site 265669000014 beta-clamp/clamp loader binding surface; other site 265669000015 beta-clamp/translesion DNA polymerase binding surface; other site 265669000016 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 265669000017 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 265669000018 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 265669000019 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 265669000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 265669000021 Walker A/P-loop; other site 265669000022 ATP binding site [chemical binding]; other site 265669000023 Q-loop/lid; other site 265669000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669000025 ABC transporter signature motif; other site 265669000026 Walker B; other site 265669000027 D-loop; other site 265669000028 H-loop/switch region; other site 265669000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 265669000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669000031 Mg2+ binding site [ion binding]; other site 265669000032 G-X-G motif; other site 265669000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 265669000034 anchoring element; other site 265669000035 dimer interface [polypeptide binding]; other site 265669000036 ATP binding site [chemical binding]; other site 265669000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 265669000038 active site 265669000039 putative metal-binding site [ion binding]; other site 265669000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 265669000041 DNA gyrase subunit A; Validated; Region: PRK05560 265669000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 265669000043 CAP-like domain; other site 265669000044 active site 265669000045 primary dimer interface [polypeptide binding]; other site 265669000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 265669000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 265669000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 265669000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 265669000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 265669000051 cardiolipin synthetase; Reviewed; Region: PRK12452 265669000052 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 265669000053 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 265669000054 putative active site [active] 265669000055 catalytic site [active] 265669000056 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 265669000057 putative active site [active] 265669000058 catalytic site [active] 265669000059 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 265669000060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669000061 Coenzyme A binding pocket [chemical binding]; other site 265669000062 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 265669000063 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 265669000064 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 265669000065 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 265669000066 diphosphomevalonate decarboxylase; Region: PLN02407 265669000067 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 265669000068 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 265669000069 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 265669000070 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 265669000071 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 265669000072 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 265669000073 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 265669000074 D-pathway; other site 265669000075 Putative ubiquinol binding site [chemical binding]; other site 265669000076 Low-spin heme (heme b) binding site [chemical binding]; other site 265669000077 Putative water exit pathway; other site 265669000078 Binuclear center (heme o3/CuB) [ion binding]; other site 265669000079 K-pathway; other site 265669000080 Putative proton exit pathway; other site 265669000081 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 265669000082 Subunit I/III interface [polypeptide binding]; other site 265669000083 Subunit III/IV interface [polypeptide binding]; other site 265669000084 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 265669000085 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 265669000086 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 265669000087 putative active site [active] 265669000088 putative metal binding site [ion binding]; other site 265669000089 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 265669000090 beta-galactosidase; Region: BGL; TIGR03356 265669000091 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 265669000092 Bacterial SH3 domain; Region: SH3_3; pfam08239 265669000093 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 265669000094 putative active site [active] 265669000095 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 265669000096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669000097 DNA-binding site [nucleotide binding]; DNA binding site 265669000098 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 265669000099 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 265669000100 active site 265669000101 active pocket/dimerization site; other site 265669000102 phosphorylation site [posttranslational modification] 265669000103 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 265669000104 active site 265669000105 phosphorylation site [posttranslational modification] 265669000106 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 265669000107 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 265669000108 hypothetical protein; Provisional; Region: PRK02947 265669000109 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 265669000110 putative active site [active] 265669000111 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 265669000112 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 265669000113 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 265669000114 active site turn [active] 265669000115 phosphorylation site [posttranslational modification] 265669000116 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 265669000117 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 265669000118 HPr interaction site; other site 265669000119 glycerol kinase (GK) interaction site [polypeptide binding]; other site 265669000120 active site 265669000121 phosphorylation site [posttranslational modification] 265669000122 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 265669000123 putative dimer interface [polypeptide binding]; other site 265669000124 catalytic triad [active] 265669000125 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 265669000126 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 265669000127 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 265669000128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669000129 active site 265669000130 motif I; other site 265669000131 motif II; other site 265669000132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669000133 Transcriptional regulators [Transcription]; Region: PurR; COG1609 265669000134 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 265669000135 DNA binding site [nucleotide binding] 265669000136 domain linker motif; other site 265669000137 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 265669000138 dimerization interface [polypeptide binding]; other site 265669000139 putative ligand binding site [chemical binding]; other site 265669000140 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 265669000141 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 265669000142 nucleotide binding site [chemical binding]; other site 265669000143 Butyrate kinase [Energy production and conversion]; Region: COG3426 265669000144 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 265669000145 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 265669000146 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 265669000147 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 265669000148 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 265669000149 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 265669000150 dimer interface [polypeptide binding]; other site 265669000151 active site 265669000152 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 265669000153 dimer interface [polypeptide binding]; other site 265669000154 active site 265669000155 putrescine carbamoyltransferase; Provisional; Region: PRK02255 265669000156 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 265669000157 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 265669000158 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 265669000159 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 265669000160 agmatine deiminase; Provisional; Region: PRK13551 265669000161 agmatine deiminase; Region: agmatine_aguA; TIGR03380 265669000162 carbamate kinase; Reviewed; Region: PRK12686 265669000163 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 265669000164 putative substrate binding site [chemical binding]; other site 265669000165 nucleotide binding site [chemical binding]; other site 265669000166 nucleotide binding site [chemical binding]; other site 265669000167 homodimer interface [polypeptide binding]; other site 265669000168 agmatine deiminase; Provisional; Region: PRK13551 265669000169 agmatine deiminase; Region: agmatine_aguA; TIGR03380 265669000170 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 265669000171 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 265669000172 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 265669000173 putative active site [active] 265669000174 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 265669000175 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 265669000176 arginine deiminase; Provisional; Region: PRK01388 265669000177 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 265669000178 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 265669000179 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 265669000180 dimer interface [polypeptide binding]; other site 265669000181 ssDNA binding site [nucleotide binding]; other site 265669000182 tetramer (dimer of dimers) interface [polypeptide binding]; other site 265669000183 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 265669000184 Predicted membrane protein [Function unknown]; Region: COG3212 265669000185 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 265669000186 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 265669000187 putative accessory gene regulator protein; Provisional; Region: PRK01100 265669000188 Staphylococcal AgrD protein; Region: AgrD; cl05477 265669000189 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 265669000190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669000191 ATP binding site [chemical binding]; other site 265669000192 Mg2+ binding site [ion binding]; other site 265669000193 G-X-G motif; other site 265669000194 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 265669000195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669000196 active site 265669000197 phosphorylation site [posttranslational modification] 265669000198 intermolecular recognition site; other site 265669000199 LytTr DNA-binding domain; Region: LytTR; pfam04397 265669000200 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 265669000201 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 265669000202 DHH family; Region: DHH; pfam01368 265669000203 DHHA1 domain; Region: DHHA1; pfam02272 265669000204 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 265669000205 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 265669000206 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 265669000207 replicative DNA helicase; Provisional; Region: PRK05748 265669000208 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 265669000209 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 265669000210 Walker A motif; other site 265669000211 ATP binding site [chemical binding]; other site 265669000212 Walker B motif; other site 265669000213 DNA binding loops [nucleotide binding] 265669000214 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 265669000215 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 265669000216 GDP-binding site [chemical binding]; other site 265669000217 ACT binding site; other site 265669000218 IMP binding site; other site 265669000219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 265669000220 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 265669000221 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 265669000222 Predicted membrane protein [Function unknown]; Region: COG1511 265669000223 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 265669000224 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 265669000225 Uncharacterized small protein [Function unknown]; Region: COG5417 265669000226 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 265669000227 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 265669000228 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 265669000229 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 265669000230 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 265669000231 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 265669000232 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 265669000233 Uncharacterized conserved protein [Function unknown]; Region: COG5444 265669000234 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 265669000235 Uncharacterized conserved protein [Function unknown]; Region: COG5444 265669000236 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 265669000237 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 265669000238 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 265669000239 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 265669000240 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 265669000241 tetramer interface [polypeptide binding]; other site 265669000242 active site 265669000243 Mg2+/Mn2+ binding site [ion binding]; other site 265669000244 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 265669000245 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 265669000246 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 265669000247 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 265669000248 DNA binding site [nucleotide binding] 265669000249 active site 265669000250 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 265669000251 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 265669000252 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 265669000253 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 265669000254 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 265669000255 putative ligand binding site [chemical binding]; other site 265669000256 putative NAD binding site [chemical binding]; other site 265669000257 catalytic site [active] 265669000258 LXG domain of WXG superfamily; Region: LXG; pfam04740 265669000259 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 265669000260 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 265669000261 DNA binding residues [nucleotide binding] 265669000262 putative dimer interface [polypeptide binding]; other site 265669000263 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 265669000264 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 265669000265 active site 265669000266 catalytic tetrad [active] 265669000267 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669000268 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 265669000269 ATP synthase subunit C; Region: ATP-synt_C; cl00466 265669000270 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 265669000271 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 265669000272 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 265669000273 Walker A motif; other site 265669000274 ATP binding site [chemical binding]; other site 265669000275 Walker B motif; other site 265669000276 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 265669000277 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 265669000278 core domain interface [polypeptide binding]; other site 265669000279 delta subunit interface [polypeptide binding]; other site 265669000280 epsilon subunit interface [polypeptide binding]; other site 265669000281 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 265669000282 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 265669000283 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 265669000284 alpha subunit interaction interface [polypeptide binding]; other site 265669000285 Walker A motif; other site 265669000286 ATP binding site [chemical binding]; other site 265669000287 Walker B motif; other site 265669000288 inhibitor binding site; inhibition site 265669000289 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 265669000290 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 265669000291 gamma subunit interface [polypeptide binding]; other site 265669000292 epsilon subunit interface [polypeptide binding]; other site 265669000293 LBP interface [polypeptide binding]; other site 265669000294 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 265669000295 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 265669000296 active pocket/dimerization site; other site 265669000297 active site 265669000298 phosphorylation site [posttranslational modification] 265669000299 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 265669000300 active site 265669000301 phosphorylation site [posttranslational modification] 265669000302 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 265669000303 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 265669000304 Domain of unknown function (DUF956); Region: DUF956; pfam06115 265669000305 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 265669000306 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 265669000307 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 265669000308 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 265669000309 dimerization interface [polypeptide binding]; other site 265669000310 putative DNA binding site [nucleotide binding]; other site 265669000311 Uncharacterized conserved protein [Function unknown]; Region: COG1359 265669000312 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 265669000313 dimer interface [polypeptide binding]; other site 265669000314 FMN binding site [chemical binding]; other site 265669000315 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 265669000316 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 265669000317 active site 265669000318 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 265669000319 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 265669000320 Interdomain contacts; other site 265669000321 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 265669000322 aromatic chitin/cellulose binding site residues [chemical binding]; other site 265669000323 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 265669000324 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 265669000325 nucleotide binding site [chemical binding]; other site 265669000326 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 265669000327 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 265669000328 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 265669000329 Walker A/P-loop; other site 265669000330 ATP binding site [chemical binding]; other site 265669000331 Q-loop/lid; other site 265669000332 ABC transporter signature motif; other site 265669000333 Walker B; other site 265669000334 D-loop; other site 265669000335 H-loop/switch region; other site 265669000336 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 265669000337 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 265669000338 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 265669000339 Walker A/P-loop; other site 265669000340 ATP binding site [chemical binding]; other site 265669000341 Q-loop/lid; other site 265669000342 ABC transporter signature motif; other site 265669000343 Walker B; other site 265669000344 D-loop; other site 265669000345 H-loop/switch region; other site 265669000346 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 265669000347 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 265669000348 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 265669000349 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 265669000350 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 265669000351 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 265669000352 substrate binding pocket [chemical binding]; other site 265669000353 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 265669000354 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669000355 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 265669000356 ligand binding site [chemical binding]; other site 265669000357 flexible hinge region; other site 265669000358 Domain of unknown function (DUF955); Region: DUF955; pfam06114 265669000359 prophage LambdaLm01; lysogenic bacteriophage region; possible monocin 265669000360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669000361 non-specific DNA binding site [nucleotide binding]; other site 265669000362 salt bridge; other site 265669000363 sequence-specific DNA binding site [nucleotide binding]; other site 265669000364 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 265669000365 Predicted secreted protein [Function unknown]; Region: COG5437 265669000366 Phage-related protein [Function unknown]; Region: COG5412 265669000367 Phage tail protein; Region: Sipho_tail; pfam05709 265669000368 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 265669000369 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 265669000370 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 265669000371 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 265669000372 active site 265669000373 metal binding site [ion binding]; metal-binding site 265669000374 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 265669000375 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 265669000376 putative active site [active] 265669000377 putative metal binding site [ion binding]; other site 265669000378 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 265669000379 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 265669000380 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 265669000381 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 265669000382 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 265669000383 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 265669000384 active site 265669000385 Uncharacterized conserved protein [Function unknown]; Region: COG3592 265669000386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669000387 Coenzyme A binding pocket [chemical binding]; other site 265669000388 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 265669000389 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 265669000390 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 265669000391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669000392 dimer interface [polypeptide binding]; other site 265669000393 conserved gate region; other site 265669000394 putative PBP binding loops; other site 265669000395 ABC-ATPase subunit interface; other site 265669000396 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 265669000397 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 265669000398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669000399 dimer interface [polypeptide binding]; other site 265669000400 conserved gate region; other site 265669000401 putative PBP binding loops; other site 265669000402 ABC-ATPase subunit interface; other site 265669000403 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 265669000404 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 265669000405 phosphoenolpyruvate synthase; Validated; Region: PRK06464 265669000406 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 265669000407 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 265669000408 peptide binding site [polypeptide binding]; other site 265669000409 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 265669000410 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 265669000411 metal binding site [ion binding]; metal-binding site 265669000412 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 265669000413 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 265669000414 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 265669000415 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 265669000416 ABC-ATPase subunit interface; other site 265669000417 dimer interface [polypeptide binding]; other site 265669000418 putative PBP binding regions; other site 265669000419 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 265669000420 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669000421 ligand binding site [chemical binding]; other site 265669000422 flexible hinge region; other site 265669000423 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 265669000424 DEAD_2; Region: DEAD_2; pfam06733 265669000425 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 265669000426 sugar phosphate phosphatase; Provisional; Region: PRK10513 265669000427 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669000428 active site 265669000429 motif I; other site 265669000430 motif II; other site 265669000431 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669000432 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 265669000433 Collagen binding domain; Region: Collagen_bind; pfam05737 265669000434 Cna protein B-type domain; Region: Cna_B; pfam05738 265669000435 Cna protein B-type domain; Region: Cna_B; pfam05738 265669000436 Cna protein B-type domain; Region: Cna_B; pfam05738 265669000437 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 265669000438 Collagen binding domain; Region: Collagen_bind; pfam05737 265669000439 Cna protein B-type domain; Region: Cna_B; pfam05738 265669000440 Cna protein B-type domain; Region: Cna_B; pfam05738 265669000441 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 265669000442 DNA polymerase III subunit delta'; Validated; Region: PRK08058 265669000443 DNA polymerase III subunit delta'; Validated; Region: PRK08485 265669000444 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 265669000445 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 265669000446 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 265669000447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669000448 S-adenosylmethionine binding site [chemical binding]; other site 265669000449 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 265669000450 GIY-YIG motif/motif A; other site 265669000451 putative active site [active] 265669000452 putative metal binding site [ion binding]; other site 265669000453 Predicted methyltransferases [General function prediction only]; Region: COG0313 265669000454 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 265669000455 putative SAM binding site [chemical binding]; other site 265669000456 putative homodimer interface [polypeptide binding]; other site 265669000457 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 265669000458 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 265669000459 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 265669000460 Uncharacterized conserved protein [Function unknown]; Region: COG5361 265669000461 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 265669000462 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 265669000463 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669000464 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 265669000465 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 265669000466 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 265669000467 active site 265669000468 HIGH motif; other site 265669000469 KMSKS motif; other site 265669000470 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 265669000471 tRNA binding surface [nucleotide binding]; other site 265669000472 anticodon binding site; other site 265669000473 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 265669000474 dimer interface [polypeptide binding]; other site 265669000475 putative tRNA-binding site [nucleotide binding]; other site 265669000476 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 265669000477 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 265669000478 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 265669000479 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 265669000480 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 265669000481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669000482 dimer interface [polypeptide binding]; other site 265669000483 conserved gate region; other site 265669000484 putative PBP binding loops; other site 265669000485 ABC-ATPase subunit interface; other site 265669000486 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 265669000487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669000488 dimer interface [polypeptide binding]; other site 265669000489 conserved gate region; other site 265669000490 putative PBP binding loops; other site 265669000491 ABC-ATPase subunit interface; other site 265669000492 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 265669000493 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 265669000494 alpha-glucosidase; Provisional; Region: PRK10426 265669000495 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 265669000496 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 265669000497 active site 265669000498 catalytic site [active] 265669000499 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 265669000500 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 265669000501 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 265669000502 trimer interface [polypeptide binding]; other site 265669000503 active site 265669000504 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 265669000505 catalytic site [active] 265669000506 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 265669000507 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 265669000508 Ca binding site [ion binding]; other site 265669000509 active site 265669000510 catalytic site [active] 265669000511 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 265669000512 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 265669000513 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 265669000514 active site 265669000515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 265669000516 Domain of unknown function (DUF348); Region: DUF348; pfam03990 265669000517 Domain of unknown function (DUF348); Region: DUF348; pfam03990 265669000518 G5 domain; Region: G5; pfam07501 265669000519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 265669000520 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 265669000521 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 265669000522 putative active site [active] 265669000523 putative metal binding site [ion binding]; other site 265669000524 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 265669000525 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 265669000526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669000527 S-adenosylmethionine binding site [chemical binding]; other site 265669000528 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 265669000529 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 265669000530 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 265669000531 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 265669000532 putative active site [active] 265669000533 YdjC motif; other site 265669000534 Mg binding site [ion binding]; other site 265669000535 putative homodimer interface [polypeptide binding]; other site 265669000536 pur operon repressor; Provisional; Region: PRK09213 265669000537 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 265669000538 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 265669000539 active site 265669000540 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 265669000541 HlyD family secretion protein; Region: HlyD_3; pfam13437 265669000542 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 265669000543 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 265669000544 Walker A/P-loop; other site 265669000545 ATP binding site [chemical binding]; other site 265669000546 Q-loop/lid; other site 265669000547 ABC transporter signature motif; other site 265669000548 Walker B; other site 265669000549 D-loop; other site 265669000550 H-loop/switch region; other site 265669000551 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 265669000552 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 265669000553 FtsX-like permease family; Region: FtsX; pfam02687 265669000554 regulatory protein SpoVG; Reviewed; Region: PRK13259 265669000555 regulatory protein SpoVG; Reviewed; Region: PRK13259 265669000556 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 265669000557 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 265669000558 Substrate binding site; other site 265669000559 Mg++ binding site; other site 265669000560 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 265669000561 active site 265669000562 substrate binding site [chemical binding]; other site 265669000563 CoA binding site [chemical binding]; other site 265669000564 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 265669000565 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 265669000566 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 265669000567 active site 265669000568 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669000569 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 265669000570 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 265669000571 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 265669000572 active site 265669000573 catalytic site [active] 265669000574 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 265669000575 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 265669000576 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 265669000577 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 265669000578 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 265669000579 active site 265669000580 Zn binding site [ion binding]; other site 265669000581 ActA Protein; Region: ActA; pfam05058 265669000582 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 265669000583 Zn binding site [ion binding]; other site 265669000584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 265669000585 hypothetical protein; Provisional; Region: PRK01119 265669000586 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 265669000587 A new structural DNA glycosylase; Region: AlkD_like; cd06561 265669000588 active site 265669000589 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 265669000590 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 265669000591 tetramer (dimer of dimers) interface [polypeptide binding]; other site 265669000592 NAD binding site [chemical binding]; other site 265669000593 dimer interface [polypeptide binding]; other site 265669000594 substrate binding site [chemical binding]; other site 265669000595 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 265669000596 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 265669000597 5S rRNA interface [nucleotide binding]; other site 265669000598 CTC domain interface [polypeptide binding]; other site 265669000599 L16 interface [polypeptide binding]; other site 265669000600 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 265669000601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669000602 Coenzyme A binding pocket [chemical binding]; other site 265669000603 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 265669000604 putative active site [active] 265669000605 catalytic residue [active] 265669000606 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 265669000607 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 265669000608 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 265669000609 ATP binding site [chemical binding]; other site 265669000610 putative Mg++ binding site [ion binding]; other site 265669000611 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 265669000612 nucleotide binding region [chemical binding]; other site 265669000613 ATP-binding site [chemical binding]; other site 265669000614 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 265669000615 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 265669000616 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 265669000617 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 265669000618 RNA binding surface [nucleotide binding]; other site 265669000619 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 265669000620 Septum formation initiator; Region: DivIC; pfam04977 265669000621 hypothetical protein; Provisional; Region: PRK08582 265669000622 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 265669000623 RNA binding site [nucleotide binding]; other site 265669000624 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 265669000625 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 265669000626 Ligand Binding Site [chemical binding]; other site 265669000627 TilS substrate C-terminal domain; Region: TilS_C; smart00977 265669000628 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 265669000629 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 265669000630 active site 265669000631 FtsH Extracellular; Region: FtsH_ext; pfam06480 265669000632 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 265669000633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669000634 Walker A motif; other site 265669000635 ATP binding site [chemical binding]; other site 265669000636 Walker B motif; other site 265669000637 arginine finger; other site 265669000638 Peptidase family M41; Region: Peptidase_M41; pfam01434 265669000639 pantothenate kinase; Reviewed; Region: PRK13318 265669000640 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 265669000641 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 265669000642 dimerization interface [polypeptide binding]; other site 265669000643 domain crossover interface; other site 265669000644 redox-dependent activation switch; other site 265669000645 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 265669000646 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 265669000647 dimer interface [polypeptide binding]; other site 265669000648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669000649 catalytic residue [active] 265669000650 dihydropteroate synthase; Region: DHPS; TIGR01496 265669000651 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 265669000652 substrate binding pocket [chemical binding]; other site 265669000653 dimer interface [polypeptide binding]; other site 265669000654 inhibitor binding site; inhibition site 265669000655 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 265669000656 homooctamer interface [polypeptide binding]; other site 265669000657 active site 265669000658 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 265669000659 catalytic center binding site [active] 265669000660 ATP binding site [chemical binding]; other site 265669000661 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 265669000662 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 265669000663 FMN binding site [chemical binding]; other site 265669000664 active site 265669000665 catalytic residues [active] 265669000666 substrate binding site [chemical binding]; other site 265669000667 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 265669000668 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 265669000669 dimer interface [polypeptide binding]; other site 265669000670 putative anticodon binding site; other site 265669000671 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 265669000672 motif 1; other site 265669000673 active site 265669000674 motif 2; other site 265669000675 motif 3; other site 265669000676 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 265669000677 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 265669000678 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 265669000679 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 265669000680 ADP binding site [chemical binding]; other site 265669000681 phosphagen binding site; other site 265669000682 substrate specificity loop; other site 265669000683 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 265669000684 Clp amino terminal domain; Region: Clp_N; pfam02861 265669000685 Clp amino terminal domain; Region: Clp_N; pfam02861 265669000686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669000687 Walker A motif; other site 265669000688 ATP binding site [chemical binding]; other site 265669000689 Walker B motif; other site 265669000690 arginine finger; other site 265669000691 UvrB/uvrC motif; Region: UVR; pfam02151 265669000692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669000693 Walker A motif; other site 265669000694 ATP binding site [chemical binding]; other site 265669000695 Walker B motif; other site 265669000696 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 265669000697 DNA repair protein RadA; Provisional; Region: PRK11823 265669000698 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 265669000699 Walker A motif/ATP binding site; other site 265669000700 ATP binding site [chemical binding]; other site 265669000701 Walker B motif; other site 265669000702 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 265669000703 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 265669000704 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 265669000705 putative active site [active] 265669000706 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 265669000707 substrate binding site; other site 265669000708 dimer interface; other site 265669000709 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 265669000710 homotrimer interaction site [polypeptide binding]; other site 265669000711 zinc binding site [ion binding]; other site 265669000712 CDP-binding sites; other site 265669000713 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 265669000714 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 265669000715 HIGH motif; other site 265669000716 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 265669000717 active site 265669000718 KMSKS motif; other site 265669000719 serine O-acetyltransferase; Region: cysE; TIGR01172 265669000720 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 265669000721 trimer interface [polypeptide binding]; other site 265669000722 active site 265669000723 substrate binding site [chemical binding]; other site 265669000724 CoA binding site [chemical binding]; other site 265669000725 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 265669000726 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 265669000727 active site 265669000728 HIGH motif; other site 265669000729 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 265669000730 KMSKS motif; other site 265669000731 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 265669000732 tRNA binding surface [nucleotide binding]; other site 265669000733 anticodon binding site; other site 265669000734 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 265669000735 active site 265669000736 metal binding site [ion binding]; metal-binding site 265669000737 dimerization interface [polypeptide binding]; other site 265669000738 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 265669000739 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 265669000740 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 265669000741 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 265669000742 RNA polymerase factor sigma-70; Validated; Region: PRK08295 265669000743 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 265669000744 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 265669000745 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 265669000746 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 265669000747 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 265669000748 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 265669000749 putative homodimer interface [polypeptide binding]; other site 265669000750 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 265669000751 heterodimer interface [polypeptide binding]; other site 265669000752 homodimer interface [polypeptide binding]; other site 265669000753 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 265669000754 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 265669000755 23S rRNA interface [nucleotide binding]; other site 265669000756 L7/L12 interface [polypeptide binding]; other site 265669000757 putative thiostrepton binding site; other site 265669000758 L25 interface [polypeptide binding]; other site 265669000759 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 265669000760 mRNA/rRNA interface [nucleotide binding]; other site 265669000761 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 265669000762 23S rRNA interface [nucleotide binding]; other site 265669000763 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 265669000764 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 265669000765 core dimer interface [polypeptide binding]; other site 265669000766 peripheral dimer interface [polypeptide binding]; other site 265669000767 L10 interface [polypeptide binding]; other site 265669000768 L11 interface [polypeptide binding]; other site 265669000769 putative EF-Tu interaction site [polypeptide binding]; other site 265669000770 putative EF-G interaction site [polypeptide binding]; other site 265669000771 Methyltransferase domain; Region: Methyltransf_31; pfam13847 265669000772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669000773 S-adenosylmethionine binding site [chemical binding]; other site 265669000774 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 265669000775 Transcriptional regulators [Transcription]; Region: PurR; COG1609 265669000776 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 265669000777 DNA binding site [nucleotide binding] 265669000778 domain linker motif; other site 265669000779 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 265669000780 putative dimerization interface [polypeptide binding]; other site 265669000781 putative ligand binding site [chemical binding]; other site 265669000782 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 265669000783 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 265669000784 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 265669000785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669000786 dimer interface [polypeptide binding]; other site 265669000787 conserved gate region; other site 265669000788 putative PBP binding loops; other site 265669000789 ABC-ATPase subunit interface; other site 265669000790 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 265669000791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669000792 dimer interface [polypeptide binding]; other site 265669000793 conserved gate region; other site 265669000794 putative PBP binding loops; other site 265669000795 ABC-ATPase subunit interface; other site 265669000796 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 265669000797 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 265669000798 Ca binding site [ion binding]; other site 265669000799 active site 265669000800 catalytic site [active] 265669000801 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 265669000802 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 265669000803 active site 265669000804 homodimer interface [polypeptide binding]; other site 265669000805 catalytic site [active] 265669000806 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 265669000807 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 265669000808 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 265669000809 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 265669000810 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 265669000811 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 265669000812 RPB10 interaction site [polypeptide binding]; other site 265669000813 RPB1 interaction site [polypeptide binding]; other site 265669000814 RPB11 interaction site [polypeptide binding]; other site 265669000815 RPB3 interaction site [polypeptide binding]; other site 265669000816 RPB12 interaction site [polypeptide binding]; other site 265669000817 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 265669000818 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 265669000819 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 265669000820 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 265669000821 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 265669000822 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 265669000823 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 265669000824 G-loop; other site 265669000825 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 265669000826 DNA binding site [nucleotide binding] 265669000827 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 265669000828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669000829 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 265669000830 motif II; other site 265669000831 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 265669000832 beta-galactosidase; Region: BGL; TIGR03356 265669000833 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 265669000834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 265669000835 Walker A/P-loop; other site 265669000836 ATP binding site [chemical binding]; other site 265669000837 Q-loop/lid; other site 265669000838 ABC transporter signature motif; other site 265669000839 Walker B; other site 265669000840 D-loop; other site 265669000841 H-loop/switch region; other site 265669000842 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 265669000843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 265669000844 Walker A/P-loop; other site 265669000845 ATP binding site [chemical binding]; other site 265669000846 Q-loop/lid; other site 265669000847 ABC transporter signature motif; other site 265669000848 Walker B; other site 265669000849 D-loop; other site 265669000850 H-loop/switch region; other site 265669000851 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 265669000852 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 265669000853 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 265669000854 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000855 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000856 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000857 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000858 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000859 LRR adjacent; Region: LRR_adjacent; pfam08191 265669000860 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669000861 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669000862 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 265669000863 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 265669000864 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000865 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000866 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000867 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000868 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000869 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000870 LRR adjacent; Region: LRR_adjacent; pfam08191 265669000871 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669000872 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669000873 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 265669000874 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000875 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000876 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 265669000877 Leucine-rich repeats; other site 265669000878 Substrate binding site [chemical binding]; other site 265669000879 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000880 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000881 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000882 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000883 LRR adjacent; Region: LRR_adjacent; pfam08191 265669000884 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669000885 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669000886 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 265669000887 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 265669000888 metal binding site [ion binding]; metal-binding site 265669000889 dimer interface [polypeptide binding]; other site 265669000890 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 265669000891 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 265669000892 putative Zn2+ binding site [ion binding]; other site 265669000893 putative DNA binding site [nucleotide binding]; other site 265669000894 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 265669000895 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 265669000896 Zn binding site [ion binding]; other site 265669000897 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 265669000898 Zn binding site [ion binding]; other site 265669000899 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 265669000900 catalytic core [active] 265669000901 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 265669000902 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 265669000903 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 265669000904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669000905 dimer interface [polypeptide binding]; other site 265669000906 conserved gate region; other site 265669000907 ABC-ATPase subunit interface; other site 265669000908 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 265669000909 Substrate binding site [chemical binding]; other site 265669000910 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000911 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000912 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000913 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000914 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669000915 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 265669000916 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 265669000917 beta-galactosidase; Region: BGL; TIGR03356 265669000918 sugar phosphate phosphatase; Provisional; Region: PRK10513 265669000919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669000920 active site 265669000921 motif I; other site 265669000922 motif II; other site 265669000923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669000924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669000925 Coenzyme A binding pocket [chemical binding]; other site 265669000926 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669000927 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 265669000928 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 265669000929 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 265669000930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669000931 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 265669000932 active site 265669000933 motif I; other site 265669000934 motif II; other site 265669000935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669000936 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 265669000937 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 265669000938 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 265669000939 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 265669000940 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 265669000941 Walker A/P-loop; other site 265669000942 ATP binding site [chemical binding]; other site 265669000943 Q-loop/lid; other site 265669000944 ABC transporter signature motif; other site 265669000945 Walker B; other site 265669000946 D-loop; other site 265669000947 H-loop/switch region; other site 265669000948 TOBE domain; Region: TOBE; pfam03459 265669000949 ATP cone domain; Region: ATP-cone; pfam03477 265669000950 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 265669000951 Class III ribonucleotide reductase; Region: RNR_III; cd01675 265669000952 effector binding site; other site 265669000953 active site 265669000954 Zn binding site [ion binding]; other site 265669000955 glycine loop; other site 265669000956 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 265669000957 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 265669000958 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669000959 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 265669000960 ligand binding site [chemical binding]; other site 265669000961 flexible hinge region; other site 265669000962 Predicted amidohydrolase [General function prediction only]; Region: COG0388 265669000963 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 265669000964 putative active site [active] 265669000965 catalytic triad [active] 265669000966 putative dimer interface [polypeptide binding]; other site 265669000967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669000968 dimer interface [polypeptide binding]; other site 265669000969 conserved gate region; other site 265669000970 ABC-ATPase subunit interface; other site 265669000971 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 265669000972 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 265669000973 Walker A/P-loop; other site 265669000974 ATP binding site [chemical binding]; other site 265669000975 Q-loop/lid; other site 265669000976 ABC transporter signature motif; other site 265669000977 Walker B; other site 265669000978 D-loop; other site 265669000979 H-loop/switch region; other site 265669000980 NIL domain; Region: NIL; pfam09383 265669000981 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 265669000982 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 265669000983 transaminase; Reviewed; Region: PRK08068 265669000984 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 265669000985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669000986 homodimer interface [polypeptide binding]; other site 265669000987 catalytic residue [active] 265669000988 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 265669000989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669000990 active site 265669000991 phosphorylation site [posttranslational modification] 265669000992 intermolecular recognition site; other site 265669000993 dimerization interface [polypeptide binding]; other site 265669000994 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 265669000995 DNA binding site [nucleotide binding] 265669000996 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 265669000997 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 265669000998 dimerization interface [polypeptide binding]; other site 265669000999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 265669001000 putative active site [active] 265669001001 heme pocket [chemical binding]; other site 265669001002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 265669001003 dimer interface [polypeptide binding]; other site 265669001004 phosphorylation site [posttranslational modification] 265669001005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669001006 ATP binding site [chemical binding]; other site 265669001007 Mg2+ binding site [ion binding]; other site 265669001008 G-X-G motif; other site 265669001009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 265669001010 YycH protein; Region: YycH; pfam07435 265669001011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 265669001012 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 265669001013 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 265669001014 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 265669001015 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 265669001016 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 265669001017 protein binding site [polypeptide binding]; other site 265669001018 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 265669001019 Transcriptional regulator [Transcription]; Region: LysR; COG0583 265669001020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 265669001021 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 265669001022 dimerization interface [polypeptide binding]; other site 265669001023 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 265669001024 dimer interface [polypeptide binding]; other site 265669001025 FMN binding site [chemical binding]; other site 265669001026 NADPH bind site [chemical binding]; other site 265669001027 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 265669001028 HTH domain; Region: HTH_11; pfam08279 265669001029 Mga helix-turn-helix domain; Region: Mga; pfam05043 265669001030 PRD domain; Region: PRD; pfam00874 265669001031 PRD domain; Region: PRD; pfam00874 265669001032 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 265669001033 active site 265669001034 P-loop; other site 265669001035 phosphorylation site [posttranslational modification] 265669001036 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669001037 active site 265669001038 phosphorylation site [posttranslational modification] 265669001039 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 265669001040 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 265669001041 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 265669001042 active site 265669001043 P-loop; other site 265669001044 phosphorylation site [posttranslational modification] 265669001045 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 265669001046 beta-galactosidase; Region: BGL; TIGR03356 265669001047 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 265669001048 methionine cluster; other site 265669001049 active site 265669001050 phosphorylation site [posttranslational modification] 265669001051 metal binding site [ion binding]; metal-binding site 265669001052 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 265669001053 putative active site [active] 265669001054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669001055 non-specific DNA binding site [nucleotide binding]; other site 265669001056 salt bridge; other site 265669001057 sequence-specific DNA binding site [nucleotide binding]; other site 265669001058 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 265669001059 cofactor binding site; other site 265669001060 DNA binding site [nucleotide binding] 265669001061 substrate interaction site [chemical binding]; other site 265669001062 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 265669001063 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 265669001064 active site 265669001065 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 265669001066 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 265669001067 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 265669001068 catalytic residue [active] 265669001069 Peptidase family M48; Region: Peptidase_M48; cl12018 265669001070 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 265669001071 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 265669001072 putative active site [active] 265669001073 YdjC motif; other site 265669001074 Mg binding site [ion binding]; other site 265669001075 putative homodimer interface [polypeptide binding]; other site 265669001076 Putative transcription activator [Transcription]; Region: TenA; COG0819 265669001077 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 265669001078 substrate binding site [chemical binding]; other site 265669001079 multimerization interface [polypeptide binding]; other site 265669001080 ATP binding site [chemical binding]; other site 265669001081 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 265669001082 dimer interface [polypeptide binding]; other site 265669001083 substrate binding site [chemical binding]; other site 265669001084 ATP binding site [chemical binding]; other site 265669001085 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 265669001086 thiamine phosphate binding site [chemical binding]; other site 265669001087 active site 265669001088 pyrophosphate binding site [ion binding]; other site 265669001089 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 265669001090 beta-galactosidase; Region: BGL; TIGR03356 265669001091 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669001092 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 265669001093 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 265669001094 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 265669001095 putative catalytic site [active] 265669001096 putative metal binding site [ion binding]; other site 265669001097 putative phosphate binding site [ion binding]; other site 265669001098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669001099 non-specific DNA binding site [nucleotide binding]; other site 265669001100 salt bridge; other site 265669001101 sequence-specific DNA binding site [nucleotide binding]; other site 265669001102 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 265669001103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669001104 non-specific DNA binding site [nucleotide binding]; other site 265669001105 salt bridge; other site 265669001106 sequence-specific DNA binding site [nucleotide binding]; other site 265669001107 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 265669001108 Leucine rich repeat; Region: LRR_8; pfam13855 265669001109 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001110 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001111 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001112 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001113 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001114 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001115 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001116 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001117 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001118 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001119 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001120 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001121 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001122 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001123 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001124 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001125 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669001126 Leucine rich repeat; Region: LRR_8; pfam13855 265669001127 LRR adjacent; Region: LRR_adjacent; pfam08191 265669001128 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669001129 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 265669001130 Leucine-rich repeats; other site 265669001131 Substrate binding site [chemical binding]; other site 265669001132 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001133 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001134 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001135 Leucine rich repeat; Region: LRR_8; pfam13855 265669001136 Leucine rich repeat; Region: LRR_8; pfam13855 265669001137 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 265669001138 Leucine-rich repeats; other site 265669001139 Substrate binding site [chemical binding]; other site 265669001140 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001141 Leucine rich repeat; Region: LRR_8; pfam13855 265669001142 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001143 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001144 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001145 LRR adjacent; Region: LRR_adjacent; pfam08191 265669001146 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001147 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001148 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001149 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 265669001150 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 265669001151 LXG domain of WXG superfamily; Region: LXG; pfam04740 265669001152 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 265669001153 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 265669001154 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 265669001155 TPP-binding site [chemical binding]; other site 265669001156 dimer interface [polypeptide binding]; other site 265669001157 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 265669001158 PYR/PP interface [polypeptide binding]; other site 265669001159 dimer interface [polypeptide binding]; other site 265669001160 TPP binding site [chemical binding]; other site 265669001161 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 265669001162 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 265669001163 active site 265669001164 intersubunit interactions; other site 265669001165 catalytic residue [active] 265669001166 short chain dehydrogenase; Provisional; Region: PRK06841 265669001167 classical (c) SDRs; Region: SDR_c; cd05233 265669001168 NAD(P) binding site [chemical binding]; other site 265669001169 active site 265669001170 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 265669001171 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 265669001172 substrate binding site [chemical binding]; other site 265669001173 dimer interface [polypeptide binding]; other site 265669001174 catalytic triad [active] 265669001175 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 265669001176 DAK2 domain; Region: Dak2; cl03685 265669001177 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 265669001178 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 265669001179 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 265669001180 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 265669001181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 265669001182 putative DNA binding site [nucleotide binding]; other site 265669001183 putative Zn2+ binding site [ion binding]; other site 265669001184 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 265669001185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669001186 Coenzyme A binding pocket [chemical binding]; other site 265669001187 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 265669001188 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 265669001189 LRR adjacent; Region: LRR_adjacent; pfam08191 265669001190 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669001191 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669001192 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 265669001193 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 265669001194 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 265669001195 acyl-activating enzyme (AAE) consensus motif; other site 265669001196 acyl-activating enzyme (AAE) consensus motif; other site 265669001197 AMP binding site [chemical binding]; other site 265669001198 active site 265669001199 CoA binding site [chemical binding]; other site 265669001200 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 265669001201 L-aspartate oxidase; Provisional; Region: PRK06175 265669001202 putative oxidoreductase; Provisional; Region: PRK10206 265669001203 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 265669001204 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 265669001205 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 265669001206 intersubunit interface [polypeptide binding]; other site 265669001207 active site 265669001208 zinc binding site [ion binding]; other site 265669001209 Na+ binding site [ion binding]; other site 265669001210 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 265669001211 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 265669001212 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 265669001213 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 265669001214 conserved cys residue [active] 265669001215 Predicted transcriptional regulator [Transcription]; Region: COG2378 265669001216 HTH domain; Region: HTH_11; pfam08279 265669001217 WYL domain; Region: WYL; pfam13280 265669001218 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 265669001219 nudix motif; other site 265669001220 hypothetical protein; Provisional; Region: PRK12378 265669001221 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 265669001222 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 265669001223 PhnA protein; Region: PhnA; pfam03831 265669001224 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 265669001225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669001226 DNA-binding site [nucleotide binding]; DNA binding site 265669001227 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 265669001228 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 265669001229 beta-galactosidase; Region: BGL; TIGR03356 265669001230 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 265669001231 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 265669001232 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 265669001233 active site 265669001234 P-loop; other site 265669001235 phosphorylation site [posttranslational modification] 265669001236 Predicted transcriptional regulator [Transcription]; Region: COG2378 265669001237 HTH domain; Region: HTH_11; pfam08279 265669001238 WYL domain; Region: WYL; pfam13280 265669001239 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 265669001240 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 265669001241 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 265669001242 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 265669001243 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 265669001244 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 265669001245 tetrameric interface [polypeptide binding]; other site 265669001246 NAD binding site [chemical binding]; other site 265669001247 catalytic residues [active] 265669001248 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 265669001249 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 265669001250 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 265669001251 substrate binding site [chemical binding]; other site 265669001252 ATP binding site [chemical binding]; other site 265669001253 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 265669001254 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 265669001255 PYR/PP interface [polypeptide binding]; other site 265669001256 dimer interface [polypeptide binding]; other site 265669001257 TPP binding site [chemical binding]; other site 265669001258 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 265669001259 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 265669001260 TPP-binding site; other site 265669001261 Uncharacterized conserved protein [Function unknown]; Region: COG5646 265669001262 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 265669001263 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 265669001264 ligand binding site [chemical binding]; other site 265669001265 active site 265669001266 UGI interface [polypeptide binding]; other site 265669001267 catalytic site [active] 265669001268 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 265669001269 hypothetical protein; Provisional; Region: PRK13665 265669001270 Bacterial SH3 domain; Region: SH3_3; cl17532 265669001271 NlpC/P60 family; Region: NLPC_P60; pfam00877 265669001272 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 265669001273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669001274 Coenzyme A binding pocket [chemical binding]; other site 265669001275 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 265669001276 pyrroline-5-carboxylate reductase; Region: PLN02688 265669001277 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669001278 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669001279 Transcriptional regulators [Transcription]; Region: GntR; COG1802 265669001280 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669001281 DNA-binding site [nucleotide binding]; DNA binding site 265669001282 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 265669001283 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 265669001284 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 265669001285 Walker A/P-loop; other site 265669001286 ATP binding site [chemical binding]; other site 265669001287 Q-loop/lid; other site 265669001288 ABC transporter signature motif; other site 265669001289 Walker B; other site 265669001290 D-loop; other site 265669001291 H-loop/switch region; other site 265669001292 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 265669001293 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 265669001294 FtsX-like permease family; Region: FtsX; pfam02687 265669001295 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 265669001296 putative hydrophobic ligand binding site [chemical binding]; other site 265669001297 alpha-mannosidase; Provisional; Region: PRK09819 265669001298 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 265669001299 active site 265669001300 metal binding site [ion binding]; metal-binding site 265669001301 catalytic site [active] 265669001302 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 265669001303 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 265669001304 HTH domain; Region: HTH_11; pfam08279 265669001305 Mga helix-turn-helix domain; Region: Mga; pfam05043 265669001306 PRD domain; Region: PRD; pfam00874 265669001307 PRD domain; Region: PRD; pfam00874 265669001308 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 265669001309 active site 265669001310 P-loop; other site 265669001311 phosphorylation site [posttranslational modification] 265669001312 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669001313 active site 265669001314 phosphorylation site [posttranslational modification] 265669001315 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 265669001316 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 265669001317 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 265669001318 putative metal binding site [ion binding]; other site 265669001319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 265669001320 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 265669001321 trimer interface [polypeptide binding]; other site 265669001322 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 265669001323 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001324 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 265669001325 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001326 Leucine-rich repeats; other site 265669001327 Substrate binding site [chemical binding]; other site 265669001328 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001329 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001330 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001331 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001332 LRR adjacent; Region: LRR_adjacent; pfam08191 265669001333 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669001334 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669001335 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669001336 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669001337 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669001338 phosphoenolpyruvate synthase; Validated; Region: PRK06241 265669001339 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 265669001340 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 265669001341 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 265669001342 ZIP Zinc transporter; Region: Zip; pfam02535 265669001343 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 265669001344 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 265669001345 NodB motif; other site 265669001346 active site 265669001347 catalytic site [active] 265669001348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669001349 non-specific DNA binding site [nucleotide binding]; other site 265669001350 salt bridge; other site 265669001351 sequence-specific DNA binding site [nucleotide binding]; other site 265669001352 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 265669001353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669001354 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 265669001355 active site 265669001356 motif I; other site 265669001357 motif II; other site 265669001358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669001359 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 265669001360 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 265669001361 HTH domain; Region: HTH_11; pfam08279 265669001362 PRD domain; Region: PRD; pfam00874 265669001363 PRD domain; Region: PRD; pfam00874 265669001364 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 265669001365 active site 265669001366 P-loop; other site 265669001367 phosphorylation site [posttranslational modification] 265669001368 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669001369 active site 265669001370 phosphorylation site [posttranslational modification] 265669001371 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669001372 active site 265669001373 phosphorylation site [posttranslational modification] 265669001374 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 265669001375 active site 265669001376 P-loop; other site 265669001377 phosphorylation site [posttranslational modification] 265669001378 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 265669001379 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 265669001380 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 265669001381 active site 265669001382 metal binding site [ion binding]; metal-binding site 265669001383 catalytic site [active] 265669001384 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 265669001385 Transcriptional regulator [Transcription]; Region: LysR; COG0583 265669001386 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 265669001387 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 265669001388 dimerization interface [polypeptide binding]; other site 265669001389 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 265669001390 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 265669001391 active site 265669001392 substrate binding site [chemical binding]; other site 265669001393 trimer interface [polypeptide binding]; other site 265669001394 CoA binding site [chemical binding]; other site 265669001395 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 265669001396 classical (c) SDRs; Region: SDR_c; cd05233 265669001397 NAD(P) binding site [chemical binding]; other site 265669001398 active site 265669001399 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 265669001400 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 265669001401 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 265669001402 RHS Repeat; Region: RHS_repeat; pfam05593 265669001403 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 265669001404 RHS Repeat; Region: RHS_repeat; pfam05593 265669001405 RHS Repeat; Region: RHS_repeat; pfam05593 265669001406 RHS Repeat; Region: RHS_repeat; pfam05593 265669001407 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 265669001408 HEAT repeats; Region: HEAT_2; pfam13646 265669001409 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 265669001410 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 265669001411 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 265669001412 Substrate binding site [chemical binding]; other site 265669001413 LRR adjacent; Region: LRR_adjacent; pfam08191 265669001414 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669001415 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669001416 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669001417 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 265669001418 Predicted transcriptional regulator [Transcription]; Region: COG1959 265669001419 Transcriptional regulator; Region: Rrf2; pfam02082 265669001420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 265669001421 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 265669001422 NAD(P) binding site [chemical binding]; other site 265669001423 active site 265669001424 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 265669001425 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 265669001426 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 265669001427 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 265669001428 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 265669001429 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 265669001430 Transcriptional regulator [Transcription]; Region: LytR; COG1316 265669001431 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 265669001432 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 265669001433 Predicted membrane protein [Function unknown]; Region: COG3619 265669001434 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 265669001435 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 265669001436 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 265669001437 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 265669001438 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 265669001439 Protein of unknown function DUF58; Region: DUF58; pfam01882 265669001440 MoxR-like ATPases [General function prediction only]; Region: COG0714 265669001441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669001442 Walker A motif; other site 265669001443 ATP binding site [chemical binding]; other site 265669001444 Walker B motif; other site 265669001445 arginine finger; other site 265669001446 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 265669001447 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 265669001448 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 265669001449 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 265669001450 Na binding site [ion binding]; other site 265669001451 Uncharacterized conserved protein [Function unknown]; Region: COG3535 265669001452 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 265669001453 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 265669001454 nucleotide binding site [chemical binding]; other site 265669001455 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 265669001456 Mga helix-turn-helix domain; Region: Mga; pfam05043 265669001457 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 265669001458 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001459 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001460 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001461 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001462 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001463 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 265669001464 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001465 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001466 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001467 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001468 Leucine rich repeat; Region: LRR_8; pfam13855 265669001469 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669001470 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 265669001471 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001472 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001473 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001474 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 265669001475 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001476 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001477 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001478 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001479 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669001480 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669001481 Transposase; Region: HTH_Tnp_1; cl17663 265669001482 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 265669001483 Zn2+ binding site [ion binding]; other site 265669001484 Mg2+ binding site [ion binding]; other site 265669001485 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 265669001486 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 265669001487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 265669001488 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 265669001489 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 265669001490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 265669001491 FeS/SAM binding site; other site 265669001492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 265669001493 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 265669001494 LXG domain of WXG superfamily; Region: LXG; pfam04740 265669001495 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 265669001496 putative FMN binding site [chemical binding]; other site 265669001497 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 265669001498 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 265669001499 nudix motif; other site 265669001500 Transcriptional regulator [Transcription]; Region: LysR; COG0583 265669001501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 265669001502 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 265669001503 putative dimerization interface [polypeptide binding]; other site 265669001504 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 265669001505 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 265669001506 active site 265669001507 FMN binding site [chemical binding]; other site 265669001508 substrate binding site [chemical binding]; other site 265669001509 putative catalytic residue [active] 265669001510 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 265669001511 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 265669001512 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 265669001513 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 265669001514 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 265669001515 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 265669001516 shikimate binding site; other site 265669001517 NAD(P) binding site [chemical binding]; other site 265669001518 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 265669001519 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 265669001520 active site 265669001521 catalytic residue [active] 265669001522 dimer interface [polypeptide binding]; other site 265669001523 Transcriptional regulator [Transcription]; Region: LysR; COG0583 265669001524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 265669001525 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 265669001526 dimerization interface [polypeptide binding]; other site 265669001527 substrate binding pocket [chemical binding]; other site 265669001528 Predicted acyl esterases [General function prediction only]; Region: COG2936 265669001529 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 265669001530 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 265669001531 active site 265669001532 catalytic triad [active] 265669001533 oxyanion hole [active] 265669001534 EamA-like transporter family; Region: EamA; pfam00892 265669001535 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 265669001536 EamA-like transporter family; Region: EamA; pfam00892 265669001537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 265669001538 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 265669001539 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 265669001540 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 265669001541 substrate binding site [chemical binding]; other site 265669001542 hexamer interface [polypeptide binding]; other site 265669001543 metal binding site [ion binding]; metal-binding site 265669001544 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 265669001545 catalytic residue [active] 265669001546 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 265669001547 PRD domain; Region: PRD; pfam00874 265669001548 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 265669001549 active site 265669001550 P-loop; other site 265669001551 phosphorylation site [posttranslational modification] 265669001552 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669001553 active site 265669001554 phosphorylation site [posttranslational modification] 265669001555 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 265669001556 putative active site [active] 265669001557 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669001558 active site 265669001559 phosphorylation site [posttranslational modification] 265669001560 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 265669001561 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 265669001562 substrate binding site [chemical binding]; other site 265669001563 hexamer interface [polypeptide binding]; other site 265669001564 metal binding site [ion binding]; metal-binding site 265669001565 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 265669001566 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 265669001567 putative NAD(P) binding site [chemical binding]; other site 265669001568 catalytic Zn binding site [ion binding]; other site 265669001569 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 265669001570 active site 265669001571 P-loop; other site 265669001572 phosphorylation site [posttranslational modification] 265669001573 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 265669001574 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 265669001575 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 265669001576 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 265669001577 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 265669001578 active site 265669001579 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 265669001580 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 265669001581 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 265669001582 catalytic triad [active] 265669001583 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 265669001584 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 265669001585 MarR family; Region: MarR_2; pfam12802 265669001586 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001587 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669001588 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 265669001589 Ligand Binding Site [chemical binding]; other site 265669001590 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 265669001591 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 265669001592 putative active site [active] 265669001593 putative metal binding site [ion binding]; other site 265669001594 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 265669001595 catalytic core [active] 265669001596 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 265669001597 Predicted membrane protein [Function unknown]; Region: COG3759 265669001598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669001599 Major Facilitator Superfamily; Region: MFS_1; pfam07690 265669001600 putative substrate translocation pore; other site 265669001601 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 265669001602 non-specific DNA interactions [nucleotide binding]; other site 265669001603 DNA binding site [nucleotide binding] 265669001604 sequence specific DNA binding site [nucleotide binding]; other site 265669001605 putative cAMP binding site [chemical binding]; other site 265669001606 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 265669001607 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 265669001608 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 265669001609 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 265669001610 NAD binding site [chemical binding]; other site 265669001611 sugar binding site [chemical binding]; other site 265669001612 divalent metal binding site [ion binding]; other site 265669001613 tetramer (dimer of dimers) interface [polypeptide binding]; other site 265669001614 dimer interface [polypeptide binding]; other site 265669001615 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 265669001616 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 265669001617 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 265669001618 putative active site [active] 265669001619 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 265669001620 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 265669001621 Sulfate transporter family; Region: Sulfate_transp; pfam00916 265669001622 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 265669001623 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 265669001624 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 265669001625 DNA binding residues [nucleotide binding] 265669001626 dimer interface [polypeptide binding]; other site 265669001627 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 265669001628 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 265669001629 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 265669001630 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 265669001631 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 265669001632 DXD motif; other site 265669001633 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 265669001634 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 265669001635 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 265669001636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669001637 S-adenosylmethionine binding site [chemical binding]; other site 265669001638 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 265669001639 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 265669001640 Transcriptional regulators [Transcription]; Region: PurR; COG1609 265669001641 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 265669001642 DNA binding site [nucleotide binding] 265669001643 domain linker motif; other site 265669001644 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 265669001645 putative dimerization interface [polypeptide binding]; other site 265669001646 putative ligand binding site [chemical binding]; other site 265669001647 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 265669001648 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 265669001649 NAD binding site [chemical binding]; other site 265669001650 sugar binding site [chemical binding]; other site 265669001651 divalent metal binding site [ion binding]; other site 265669001652 tetramer (dimer of dimers) interface [polypeptide binding]; other site 265669001653 dimer interface [polypeptide binding]; other site 265669001654 allantoate amidohydrolase; Reviewed; Region: PRK09290 265669001655 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 265669001656 active site 265669001657 metal binding site [ion binding]; metal-binding site 265669001658 dimer interface [polypeptide binding]; other site 265669001659 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 265669001660 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 265669001661 metal binding site [ion binding]; metal-binding site 265669001662 putative dimer interface [polypeptide binding]; other site 265669001663 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 265669001664 Beta-lactamase; Region: Beta-lactamase; pfam00144 265669001665 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 265669001666 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 265669001667 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 265669001668 intersubunit interface [polypeptide binding]; other site 265669001669 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 265669001670 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 265669001671 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 265669001672 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 265669001673 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 265669001674 Glucitol operon activator protein (GutM); Region: GutM; cl01890 265669001675 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 265669001676 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 265669001677 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 265669001678 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 265669001679 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 265669001680 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669001681 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 265669001682 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001683 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001684 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001685 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669001686 WxL domain surface cell wall-binding; Region: WxL; pfam13731 265669001687 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 265669001688 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 265669001689 FOG: CBS domain [General function prediction only]; Region: COG0517 265669001690 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 265669001691 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 265669001692 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 265669001693 dimer interface [polypeptide binding]; other site 265669001694 active site 265669001695 metal binding site [ion binding]; metal-binding site 265669001696 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 265669001697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669001698 putative substrate translocation pore; other site 265669001699 POT family; Region: PTR2; pfam00854 265669001700 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 265669001701 catalytic core [active] 265669001702 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 265669001703 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 265669001704 catalytic core [active] 265669001705 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 265669001706 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 265669001707 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 265669001708 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 265669001709 Cl binding site [ion binding]; other site 265669001710 oligomer interface [polypeptide binding]; other site 265669001711 glutamate dehydrogenase; Provisional; Region: PRK09414 265669001712 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 265669001713 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 265669001714 NAD(P) binding site [chemical binding]; other site 265669001715 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 265669001716 metal binding site [ion binding]; metal-binding site 265669001717 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 265669001718 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 265669001719 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 265669001720 substrate binding site [chemical binding]; other site 265669001721 glutamase interaction surface [polypeptide binding]; other site 265669001722 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 265669001723 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 265669001724 catalytic residues [active] 265669001725 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 265669001726 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 265669001727 putative active site [active] 265669001728 oxyanion strand; other site 265669001729 catalytic triad [active] 265669001730 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 265669001731 putative active site pocket [active] 265669001732 4-fold oligomerization interface [polypeptide binding]; other site 265669001733 metal binding residues [ion binding]; metal-binding site 265669001734 3-fold/trimer interface [polypeptide binding]; other site 265669001735 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 265669001736 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 265669001737 NAD binding site [chemical binding]; other site 265669001738 dimerization interface [polypeptide binding]; other site 265669001739 product binding site; other site 265669001740 substrate binding site [chemical binding]; other site 265669001741 zinc binding site [ion binding]; other site 265669001742 catalytic residues [active] 265669001743 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 265669001744 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 265669001745 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 265669001746 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 265669001747 dimer interface [polypeptide binding]; other site 265669001748 motif 1; other site 265669001749 active site 265669001750 motif 2; other site 265669001751 motif 3; other site 265669001752 histidinol-phosphatase; Reviewed; Region: PRK08123 265669001753 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 265669001754 active site 265669001755 dimer interface [polypeptide binding]; other site 265669001756 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 265669001757 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 265669001758 DNA binding site [nucleotide binding] 265669001759 active site 265669001760 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 265669001761 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 265669001762 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 265669001763 beta-galactosidase; Region: BGL; TIGR03356 265669001764 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 265669001765 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669001766 DNA-binding site [nucleotide binding]; DNA binding site 265669001767 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 265669001768 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001769 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001770 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 265669001771 Uncharacterized conserved protein [Function unknown]; Region: COG2966 265669001772 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 265669001773 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 265669001774 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 265669001775 Predicted esterase [General function prediction only]; Region: COG0400 265669001776 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 265669001777 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 265669001778 putative RNA binding site [nucleotide binding]; other site 265669001779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669001780 S-adenosylmethionine binding site [chemical binding]; other site 265669001781 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 265669001782 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 265669001783 Bacterial SH3 domain; Region: SH3_3; pfam08239 265669001784 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 265669001785 NlpC/P60 family; Region: NLPC_P60; pfam00877 265669001786 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 265669001787 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 265669001788 ATP binding site [chemical binding]; other site 265669001789 putative Mg++ binding site [ion binding]; other site 265669001790 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 265669001791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 265669001792 nucleotide binding region [chemical binding]; other site 265669001793 ATP-binding site [chemical binding]; other site 265669001794 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 265669001795 Domain of unknown function DUF20; Region: UPF0118; pfam01594 265669001796 WxL domain surface cell wall-binding; Region: WxL; pfam13731 265669001797 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 265669001798 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 265669001799 UreD urease accessory protein; Region: UreD; cl00530 265669001800 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 265669001801 DNA photolyase; Region: DNA_photolyase; pfam00875 265669001802 Predicted membrane protein [Function unknown]; Region: COG4852 265669001803 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 265669001804 DAK2 domain; Region: Dak2; pfam02734 265669001805 EDD domain protein, DegV family; Region: DegV; TIGR00762 265669001806 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 265669001807 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 265669001808 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 265669001809 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 265669001810 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 265669001811 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 265669001812 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 265669001813 homodimer interface [polypeptide binding]; other site 265669001814 substrate-cofactor binding pocket; other site 265669001815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669001816 catalytic residue [active] 265669001817 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 265669001818 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669001819 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 265669001820 ligand binding site [chemical binding]; other site 265669001821 flexible hinge region; other site 265669001822 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 265669001823 BioY family; Region: BioY; pfam02632 265669001824 Predicted transcriptional regulators [Transcription]; Region: COG1695 265669001825 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 265669001826 Predicted membrane protein [Function unknown]; Region: COG4709 265669001827 Uncharacterized conserved protein [Function unknown]; Region: COG3595 265669001828 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 265669001829 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 265669001830 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 265669001831 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 265669001832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669001833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 265669001834 Coenzyme A binding pocket [chemical binding]; other site 265669001835 Tic20-like protein; Region: Tic20; pfam09685 265669001836 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 265669001837 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 265669001838 Transcriptional regulators [Transcription]; Region: MarR; COG1846 265669001839 MarR family; Region: MarR_2; pfam12802 265669001840 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 265669001841 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 265669001842 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669001843 Walker A/P-loop; other site 265669001844 ATP binding site [chemical binding]; other site 265669001845 Q-loop/lid; other site 265669001846 ABC transporter signature motif; other site 265669001847 Walker B; other site 265669001848 D-loop; other site 265669001849 H-loop/switch region; other site 265669001850 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 265669001851 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 265669001852 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 265669001853 Walker A/P-loop; other site 265669001854 ATP binding site [chemical binding]; other site 265669001855 Q-loop/lid; other site 265669001856 ABC transporter signature motif; other site 265669001857 Walker B; other site 265669001858 D-loop; other site 265669001859 H-loop/switch region; other site 265669001860 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 265669001861 active site residue [active] 265669001862 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669001863 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 265669001864 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 265669001865 Transcriptional regulators [Transcription]; Region: MarR; COG1846 265669001866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 265669001867 putative DNA binding site [nucleotide binding]; other site 265669001868 putative Zn2+ binding site [ion binding]; other site 265669001869 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 265669001870 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 265669001871 putative NAD(P) binding site [chemical binding]; other site 265669001872 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 265669001873 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 265669001874 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 265669001875 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 265669001876 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 265669001877 putative active site [active] 265669001878 catalytic site [active] 265669001879 putative metal binding site [ion binding]; other site 265669001880 Catalytic domain of Protein Kinases; Region: PKc; cd00180 265669001881 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 265669001882 active site 265669001883 ATP binding site [chemical binding]; other site 265669001884 substrate binding site [chemical binding]; other site 265669001885 activation loop (A-loop); other site 265669001886 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 265669001887 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 265669001888 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 265669001889 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 265669001890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669001891 Coenzyme A binding pocket [chemical binding]; other site 265669001892 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 265669001893 active site 265669001894 catalytic triad [active] 265669001895 oxyanion hole [active] 265669001896 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 265669001897 domain interaction interfaces [polypeptide binding]; other site 265669001898 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 265669001899 domain interaction interfaces [polypeptide binding]; other site 265669001900 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 265669001901 domain interaction interfaces [polypeptide binding]; other site 265669001902 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 265669001903 domain interaction interfaces [polypeptide binding]; other site 265669001904 Isochorismatase family; Region: Isochorismatase; pfam00857 265669001905 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 265669001906 catalytic triad [active] 265669001907 conserved cis-peptide bond; other site 265669001908 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 265669001909 PRD domain; Region: PRD; pfam00874 265669001910 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 265669001911 active site 265669001912 P-loop; other site 265669001913 phosphorylation site [posttranslational modification] 265669001914 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669001915 active site 265669001916 phosphorylation site [posttranslational modification] 265669001917 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669001918 active site 265669001919 phosphorylation site [posttranslational modification] 265669001920 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 265669001921 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 265669001922 active site 265669001923 P-loop; other site 265669001924 phosphorylation site [posttranslational modification] 265669001925 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 265669001926 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 265669001927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669001928 motif II; other site 265669001929 Predicted transcriptional regulator [Transcription]; Region: COG1959 265669001930 Transcriptional regulator; Region: Rrf2; pfam02082 265669001931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669001932 S-adenosylmethionine binding site [chemical binding]; other site 265669001933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 265669001934 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 265669001935 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 265669001936 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 265669001937 active site 265669001938 catalytic tetrad [active] 265669001939 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 265669001940 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 265669001941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669001942 motif II; other site 265669001943 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 265669001944 catalytic residue [active] 265669001945 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 265669001946 Sulfatase; Region: Sulfatase; pfam00884 265669001947 amino acid transporter; Region: 2A0306; TIGR00909 265669001948 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 265669001949 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 265669001950 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 265669001951 putative metal binding site [ion binding]; other site 265669001952 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 265669001953 active site 265669001954 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 265669001955 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 265669001956 Cl binding site [ion binding]; other site 265669001957 oligomer interface [polypeptide binding]; other site 265669001958 Transcriptional regulators [Transcription]; Region: GntR; COG1802 265669001959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669001960 DNA-binding site [nucleotide binding]; DNA binding site 265669001961 Predicted membrane protein [Function unknown]; Region: COG1511 265669001962 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 265669001963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669001964 Transcriptional regulators [Transcription]; Region: GntR; COG1802 265669001965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669001966 DNA-binding site [nucleotide binding]; DNA binding site 265669001967 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 265669001968 Predicted integral membrane protein [Function unknown]; Region: COG5523 265669001969 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 265669001970 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 265669001971 active site 265669001972 metal binding site [ion binding]; metal-binding site 265669001973 AAA domain; Region: AAA_13; pfam13166 265669001974 Predicted membrane protein [Function unknown]; Region: COG2322 265669001975 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 265669001976 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 265669001977 minor groove reading motif; other site 265669001978 helix-hairpin-helix signature motif; other site 265669001979 substrate binding pocket [chemical binding]; other site 265669001980 active site 265669001981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669001982 non-specific DNA binding site [nucleotide binding]; other site 265669001983 salt bridge; other site 265669001984 sequence-specific DNA binding site [nucleotide binding]; other site 265669001985 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 265669001986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 265669001987 Transposase; Region: HTH_Tnp_1; cl17663 265669001988 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669001989 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001990 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669001991 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 265669001992 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 265669001993 dimer interface [polypeptide binding]; other site 265669001994 substrate binding site [chemical binding]; other site 265669001995 ATP binding site [chemical binding]; other site 265669001996 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 265669001997 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669001998 active site 265669001999 motif I; other site 265669002000 motif II; other site 265669002001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669002002 maltose O-acetyltransferase; Provisional; Region: PRK10092 265669002003 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 265669002004 active site 265669002005 substrate binding site [chemical binding]; other site 265669002006 trimer interface [polypeptide binding]; other site 265669002007 CoA binding site [chemical binding]; other site 265669002008 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 265669002009 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 265669002010 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 265669002011 Walker A/P-loop; other site 265669002012 ATP binding site [chemical binding]; other site 265669002013 Q-loop/lid; other site 265669002014 ABC transporter signature motif; other site 265669002015 Walker B; other site 265669002016 D-loop; other site 265669002017 H-loop/switch region; other site 265669002018 inner membrane transport permease; Provisional; Region: PRK15066 265669002019 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 265669002020 oxidoreductase; Provisional; Region: PRK07985 265669002021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 265669002022 NAD(P) binding site [chemical binding]; other site 265669002023 active site 265669002024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 265669002025 Predicted membrane protein [Function unknown]; Region: COG3152 265669002026 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 265669002027 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 265669002028 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 265669002029 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 265669002030 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 265669002031 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 265669002032 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 265669002033 FHIPEP family; Region: FHIPEP; pfam00771 265669002034 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 265669002035 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 265669002036 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 265669002037 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 265669002038 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 265669002039 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 265669002040 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 265669002041 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 265669002042 flagellar motor protein MotA; Validated; Region: PRK08124 265669002043 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 265669002044 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 265669002045 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 265669002046 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 265669002047 ligand binding site [chemical binding]; other site 265669002048 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 265669002049 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 265669002050 putative metal binding site; other site 265669002051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 265669002052 binding surface 265669002053 TPR motif; other site 265669002054 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 265669002055 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 265669002056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669002057 active site 265669002058 phosphorylation site [posttranslational modification] 265669002059 intermolecular recognition site; other site 265669002060 dimerization interface [polypeptide binding]; other site 265669002061 flagellin; Provisional; Region: PRK12805 265669002062 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 265669002063 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 265669002064 Response regulator receiver domain; Region: Response_reg; pfam00072 265669002065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669002066 active site 265669002067 phosphorylation site [posttranslational modification] 265669002068 intermolecular recognition site; other site 265669002069 dimerization interface [polypeptide binding]; other site 265669002070 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 265669002071 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 265669002072 putative binding surface; other site 265669002073 active site 265669002074 P2 response regulator binding domain; Region: P2; pfam07194 265669002075 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 265669002076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669002077 ATP binding site [chemical binding]; other site 265669002078 Mg2+ binding site [ion binding]; other site 265669002079 G-X-G motif; other site 265669002080 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 265669002081 flagellar motor switch protein; Validated; Region: PRK06788 265669002082 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 265669002083 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 265669002084 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 265669002085 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 265669002086 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 265669002087 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 265669002088 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 265669002089 flagellar motor switch protein; Validated; Region: PRK06789 265669002090 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 265669002091 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 265669002092 flagellar motor switch protein; Reviewed; Region: PRK06782 265669002093 CheC-like family; Region: CheC; pfam04509 265669002094 CheC-like family; Region: CheC; pfam04509 265669002095 Chemotaxis phosphatase CheX; Region: CheX; cl15816 265669002096 CheC-like family; Region: CheC; pfam04509 265669002097 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 265669002098 Protein of unknown function (DUF327); Region: DUF327; pfam03885 265669002099 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 265669002100 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 265669002101 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 265669002102 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 265669002103 flagellar capping protein; Validated; Region: fliD; PRK06798 265669002104 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 265669002105 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 265669002106 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 265669002107 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 265669002108 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 265669002109 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 265669002110 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 265669002111 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 265669002112 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 265669002113 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 265669002114 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 265669002115 FliG C-terminal domain; Region: FliG_C; pfam01706 265669002116 flagellar assembly protein H; Validated; Region: fliH; PRK06800 265669002117 Flagellar assembly protein FliH; Region: FliH; pfam02108 265669002118 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 265669002119 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 265669002120 Walker A motif; other site 265669002121 ATP binding site [chemical binding]; other site 265669002122 Walker B motif; other site 265669002123 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 265669002124 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 265669002125 N-acetyl-D-glucosamine binding site [chemical binding]; other site 265669002126 catalytic residue [active] 265669002127 Predicted transcriptional regulators [Transcription]; Region: COG1695 265669002128 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 265669002129 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 265669002130 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 265669002131 pyruvate oxidase; Provisional; Region: PRK08611 265669002132 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 265669002133 PYR/PP interface [polypeptide binding]; other site 265669002134 dimer interface [polypeptide binding]; other site 265669002135 tetramer interface [polypeptide binding]; other site 265669002136 TPP binding site [chemical binding]; other site 265669002137 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 265669002138 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 265669002139 TPP-binding site [chemical binding]; other site 265669002140 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 265669002141 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 265669002142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 265669002143 dimerization interface [polypeptide binding]; other site 265669002144 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 265669002145 dimer interface [polypeptide binding]; other site 265669002146 putative CheW interface [polypeptide binding]; other site 265669002147 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 265669002148 putative active site [active] 265669002149 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 265669002150 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 265669002151 glutaminase active site [active] 265669002152 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 265669002153 dimer interface [polypeptide binding]; other site 265669002154 active site 265669002155 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 265669002156 dimer interface [polypeptide binding]; other site 265669002157 active site 265669002158 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 265669002159 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 265669002160 active site 265669002161 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 265669002162 GIY-YIG motif/motif A; other site 265669002163 Leucine rich repeat; Region: LRR_8; pfam13855 265669002164 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669002165 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669002166 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669002167 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 265669002168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669002169 non-specific DNA binding site [nucleotide binding]; other site 265669002170 salt bridge; other site 265669002171 sequence-specific DNA binding site [nucleotide binding]; other site 265669002172 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669002173 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 265669002174 ligand binding site [chemical binding]; other site 265669002175 flexible hinge region; other site 265669002176 Predicted transcriptional regulators [Transcription]; Region: COG1725 265669002177 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669002178 DNA-binding site [nucleotide binding]; DNA binding site 265669002179 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 265669002180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669002181 Walker A/P-loop; other site 265669002182 ATP binding site [chemical binding]; other site 265669002183 Q-loop/lid; other site 265669002184 ABC transporter signature motif; other site 265669002185 Walker B; other site 265669002186 D-loop; other site 265669002187 H-loop/switch region; other site 265669002188 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 265669002189 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 265669002190 Walker A/P-loop; other site 265669002191 ATP binding site [chemical binding]; other site 265669002192 Q-loop/lid; other site 265669002193 ABC transporter signature motif; other site 265669002194 Walker B; other site 265669002195 D-loop; other site 265669002196 H-loop/switch region; other site 265669002197 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 265669002198 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 265669002199 FtsX-like permease family; Region: FtsX; pfam02687 265669002200 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 265669002201 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669002202 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 265669002203 ligand binding site [chemical binding]; other site 265669002204 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 265669002205 non-specific DNA interactions [nucleotide binding]; other site 265669002206 DNA binding site [nucleotide binding] 265669002207 sequence specific DNA binding site [nucleotide binding]; other site 265669002208 putative cAMP binding site [chemical binding]; other site 265669002209 SnoaL-like domain; Region: SnoaL_4; pfam13577 265669002210 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 265669002211 active site 265669002212 catalytic triad [active] 265669002213 oxyanion hole [active] 265669002214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669002215 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 265669002216 Walker A/P-loop; other site 265669002217 ATP binding site [chemical binding]; other site 265669002218 Q-loop/lid; other site 265669002219 ABC transporter signature motif; other site 265669002220 Walker B; other site 265669002221 D-loop; other site 265669002222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 265669002223 H-loop/switch region; other site 265669002224 active site 265669002225 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 265669002226 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 265669002227 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 265669002228 Zn binding site [ion binding]; other site 265669002229 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 265669002230 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 265669002231 Zn binding site [ion binding]; other site 265669002232 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 265669002233 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 265669002234 Zn binding site [ion binding]; other site 265669002235 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 265669002236 Zn binding site [ion binding]; other site 265669002237 Predicted esterase [General function prediction only]; Region: COG0400 265669002238 putative hydrolase; Provisional; Region: PRK11460 265669002239 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 265669002240 GTPases [General function prediction only]; Region: HflX; COG2262 265669002241 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 265669002242 HflX GTPase family; Region: HflX; cd01878 265669002243 G1 box; other site 265669002244 GTP/Mg2+ binding site [chemical binding]; other site 265669002245 Switch I region; other site 265669002246 G2 box; other site 265669002247 G3 box; other site 265669002248 Switch II region; other site 265669002249 G4 box; other site 265669002250 G5 box; other site 265669002251 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 265669002252 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 265669002253 putative active site [active] 265669002254 putative metal binding site [ion binding]; other site 265669002255 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 265669002256 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 265669002257 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 265669002258 Transcriptional regulators [Transcription]; Region: GntR; COG1802 265669002259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669002260 DNA-binding site [nucleotide binding]; DNA binding site 265669002261 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 265669002262 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 265669002263 putative NADP binding site [chemical binding]; other site 265669002264 putative dimer interface [polypeptide binding]; other site 265669002265 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 265669002266 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 265669002267 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 265669002268 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 265669002269 nucleotide binding site [chemical binding]; other site 265669002270 Predicted membrane protein [Function unknown]; Region: COG4811 265669002271 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 265669002272 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 265669002273 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 265669002274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669002275 Walker A motif; other site 265669002276 ATP binding site [chemical binding]; other site 265669002277 Walker B motif; other site 265669002278 arginine finger; other site 265669002279 Transcriptional antiterminator [Transcription]; Region: COG3933 265669002280 PRD domain; Region: PRD; pfam00874 265669002281 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 265669002282 active pocket/dimerization site; other site 265669002283 active site 265669002284 phosphorylation site [posttranslational modification] 265669002285 PRD domain; Region: PRD; pfam00874 265669002286 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 265669002287 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 265669002288 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 265669002289 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 265669002290 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 265669002291 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 265669002292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 265669002293 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 265669002294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 265669002295 Leucine rich repeat; Region: LRR_8; pfam13855 265669002296 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669002297 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669002298 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669002299 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669002300 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669002301 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669002302 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 265669002303 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 265669002304 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 265669002305 putative deacylase active site [active] 265669002306 Predicted amidohydrolase [General function prediction only]; Region: COG0388 265669002307 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 265669002308 active site 265669002309 catalytic triad [active] 265669002310 dimer interface [polypeptide binding]; other site 265669002311 Protein of unknown function (DUF554); Region: DUF554; pfam04474 265669002312 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 265669002313 NADH(P)-binding; Region: NAD_binding_10; pfam13460 265669002314 NAD binding site [chemical binding]; other site 265669002315 substrate binding site [chemical binding]; other site 265669002316 putative active site [active] 265669002317 Predicted permeases [General function prediction only]; Region: RarD; COG2962 265669002318 EamA-like transporter family; Region: EamA; pfam00892 265669002319 Uncharacterized conserved protein [Function unknown]; Region: COG2353 265669002320 Transcriptional regulators [Transcription]; Region: MarR; COG1846 265669002321 MarR family; Region: MarR_2; pfam12802 265669002322 lysine transporter; Provisional; Region: PRK10836 265669002323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 265669002324 PAS domain; Region: PAS_9; pfam13426 265669002325 putative active site [active] 265669002326 heme pocket [chemical binding]; other site 265669002327 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 265669002328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 265669002329 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 265669002330 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 265669002331 synthetase active site [active] 265669002332 NTP binding site [chemical binding]; other site 265669002333 metal binding site [ion binding]; metal-binding site 265669002334 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 265669002335 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 265669002336 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669002337 non-specific DNA binding site [nucleotide binding]; other site 265669002338 salt bridge; other site 265669002339 sequence-specific DNA binding site [nucleotide binding]; other site 265669002340 Cupin domain; Region: Cupin_2; pfam07883 265669002341 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 265669002342 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 265669002343 Walker A/P-loop; other site 265669002344 ATP binding site [chemical binding]; other site 265669002345 Q-loop/lid; other site 265669002346 ABC transporter signature motif; other site 265669002347 Walker B; other site 265669002348 D-loop; other site 265669002349 H-loop/switch region; other site 265669002350 TOBE domain; Region: TOBE_2; pfam08402 265669002351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 265669002352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669002353 putative PBP binding loops; other site 265669002354 ABC-ATPase subunit interface; other site 265669002355 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 265669002356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669002357 dimer interface [polypeptide binding]; other site 265669002358 conserved gate region; other site 265669002359 putative PBP binding loops; other site 265669002360 ABC-ATPase subunit interface; other site 265669002361 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 265669002362 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 265669002363 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 265669002364 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 265669002365 active site 265669002366 zinc binding site [ion binding]; other site 265669002367 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 265669002368 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 265669002369 Zn2+ binding site [ion binding]; other site 265669002370 Mg2+ binding site [ion binding]; other site 265669002371 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 265669002372 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 265669002373 nucleotide binding site [chemical binding]; other site 265669002374 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 265669002375 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 265669002376 FMN binding site [chemical binding]; other site 265669002377 substrate binding site [chemical binding]; other site 265669002378 putative catalytic residue [active] 265669002379 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 265669002380 LXG domain of WXG superfamily; Region: LXG; pfam04740 265669002381 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 265669002382 dimer interface [polypeptide binding]; other site 265669002383 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 265669002384 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 265669002385 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 265669002386 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 265669002387 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 265669002388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669002389 motif II; other site 265669002390 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 265669002391 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 265669002392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669002393 Coenzyme A binding pocket [chemical binding]; other site 265669002394 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 265669002395 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 265669002396 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 265669002397 DNA binding residues [nucleotide binding] 265669002398 putative dimer interface [polypeptide binding]; other site 265669002399 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 265669002400 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 265669002401 active site 265669002402 catalytic tetrad [active] 265669002403 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 265669002404 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 265669002405 homodimer interface [polypeptide binding]; other site 265669002406 catalytic residues [active] 265669002407 NAD binding site [chemical binding]; other site 265669002408 substrate binding pocket [chemical binding]; other site 265669002409 flexible flap; other site 265669002410 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 265669002411 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 265669002412 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 265669002413 PhoU domain; Region: PhoU; pfam01895 265669002414 PhoU domain; Region: PhoU; pfam01895 265669002415 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 265669002416 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 265669002417 dimer interface [polypeptide binding]; other site 265669002418 PYR/PP interface [polypeptide binding]; other site 265669002419 TPP binding site [chemical binding]; other site 265669002420 substrate binding site [chemical binding]; other site 265669002421 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 265669002422 Domain of unknown function; Region: EKR; smart00890 265669002423 4Fe-4S binding domain; Region: Fer4_6; pfam12837 265669002424 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 265669002425 TPP-binding site [chemical binding]; other site 265669002426 dimer interface [polypeptide binding]; other site 265669002427 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 265669002428 Predicted permeases [General function prediction only]; Region: COG0679 265669002429 Helix-turn-helix domain; Region: HTH_28; pfam13518 265669002430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669002431 non-specific DNA binding site [nucleotide binding]; other site 265669002432 salt bridge; other site 265669002433 sequence-specific DNA binding site [nucleotide binding]; other site 265669002434 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 265669002435 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669002436 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669002437 Predicted membrane protein [Function unknown]; Region: COG3223 265669002438 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 265669002439 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 265669002440 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 265669002441 Walker A/P-loop; other site 265669002442 ATP binding site [chemical binding]; other site 265669002443 Q-loop/lid; other site 265669002444 ABC transporter signature motif; other site 265669002445 Walker B; other site 265669002446 D-loop; other site 265669002447 H-loop/switch region; other site 265669002448 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 265669002449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669002450 putative substrate translocation pore; other site 265669002451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669002452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669002453 Major Facilitator Superfamily; Region: MFS_1; pfam07690 265669002454 putative substrate translocation pore; other site 265669002455 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 265669002456 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 265669002457 putative DNA binding site [nucleotide binding]; other site 265669002458 putative Zn2+ binding site [ion binding]; other site 265669002459 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 265669002460 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 265669002461 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 265669002462 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 265669002463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669002464 motif II; other site 265669002465 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 265669002466 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669002467 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669002468 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669002469 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669002470 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669002471 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669002472 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669002473 Predicted membrane protein [Function unknown]; Region: COG3326 265669002474 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 265669002475 homotrimer interaction site [polypeptide binding]; other site 265669002476 putative active site [active] 265669002477 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 265669002478 substrate binding site [chemical binding]; other site 265669002479 zinc-binding site [ion binding]; other site 265669002480 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 265669002481 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 265669002482 GIY-YIG motif/motif A; other site 265669002483 active site 265669002484 catalytic site [active] 265669002485 putative DNA binding site [nucleotide binding]; other site 265669002486 metal binding site [ion binding]; metal-binding site 265669002487 UvrB/uvrC motif; Region: UVR; pfam02151 265669002488 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 265669002489 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 265669002490 substrate binding pocket [chemical binding]; other site 265669002491 membrane-bound complex binding site; other site 265669002492 hinge residues; other site 265669002493 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 265669002494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669002495 dimer interface [polypeptide binding]; other site 265669002496 conserved gate region; other site 265669002497 putative PBP binding loops; other site 265669002498 ABC-ATPase subunit interface; other site 265669002499 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 265669002500 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 265669002501 Walker A/P-loop; other site 265669002502 ATP binding site [chemical binding]; other site 265669002503 Q-loop/lid; other site 265669002504 ABC transporter signature motif; other site 265669002505 Walker B; other site 265669002506 D-loop; other site 265669002507 H-loop/switch region; other site 265669002508 amidase; Provisional; Region: PRK11910 265669002509 Amidase; Region: Amidase; cl11426 265669002510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 265669002511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 265669002512 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 265669002513 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 265669002514 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 265669002515 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 265669002516 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 265669002517 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 265669002518 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 265669002519 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 265669002520 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 265669002521 Esterase/lipase [General function prediction only]; Region: COG1647 265669002522 Transcriptional regulators [Transcription]; Region: PurR; COG1609 265669002523 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 265669002524 DNA binding site [nucleotide binding] 265669002525 domain linker motif; other site 265669002526 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 265669002527 putative dimerization interface [polypeptide binding]; other site 265669002528 putative ligand binding site [chemical binding]; other site 265669002529 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 265669002530 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 265669002531 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 265669002532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669002533 dimer interface [polypeptide binding]; other site 265669002534 conserved gate region; other site 265669002535 putative PBP binding loops; other site 265669002536 ABC-ATPase subunit interface; other site 265669002537 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 265669002538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669002539 dimer interface [polypeptide binding]; other site 265669002540 conserved gate region; other site 265669002541 ABC-ATPase subunit interface; other site 265669002542 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 265669002543 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 265669002544 Ca binding site [ion binding]; other site 265669002545 active site 265669002546 catalytic site [active] 265669002547 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 265669002548 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 265669002549 active site 265669002550 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 265669002551 active site 265669002552 substrate binding site [chemical binding]; other site 265669002553 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 265669002554 metal binding site [ion binding]; metal-binding site 265669002555 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 265669002556 DEAD-like helicases superfamily; Region: DEXDc; smart00487 265669002557 ATP binding site [chemical binding]; other site 265669002558 Mg++ binding site [ion binding]; other site 265669002559 motif III; other site 265669002560 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 265669002561 nucleotide binding region [chemical binding]; other site 265669002562 ATP-binding site [chemical binding]; other site 265669002563 Predicted membrane protein [Function unknown]; Region: COG4708 265669002564 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 265669002565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 265669002566 Predicted transcriptional regulators [Transcription]; Region: COG1733 265669002567 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 265669002568 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 265669002569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669002570 putative substrate translocation pore; other site 265669002571 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 265669002572 PRD domain; Region: PRD; pfam00874 265669002573 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 265669002574 active site 265669002575 P-loop; other site 265669002576 phosphorylation site [posttranslational modification] 265669002577 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669002578 active site 265669002579 phosphorylation site [posttranslational modification] 265669002580 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 265669002581 methionine cluster; other site 265669002582 active site 265669002583 phosphorylation site [posttranslational modification] 265669002584 metal binding site [ion binding]; metal-binding site 265669002585 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 265669002586 active site 265669002587 P-loop; other site 265669002588 phosphorylation site [posttranslational modification] 265669002589 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 265669002590 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 265669002591 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 265669002592 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 265669002593 active site 265669002594 trimer interface [polypeptide binding]; other site 265669002595 allosteric site; other site 265669002596 active site lid [active] 265669002597 hexamer (dimer of trimers) interface [polypeptide binding]; other site 265669002598 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 265669002599 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 265669002600 active site 265669002601 catalytic tetrad [active] 265669002602 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 265669002603 Collagen binding domain; Region: Collagen_bind; pfam05737 265669002604 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 265669002605 Uncharacterized conserved protein [Function unknown]; Region: COG3402 265669002606 Predicted membrane protein [Function unknown]; Region: COG3428 265669002607 Bacterial PH domain; Region: DUF304; pfam03703 265669002608 Bacterial PH domain; Region: DUF304; pfam03703 265669002609 Bacterial PH domain; Region: DUF304; pfam03703 265669002610 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 265669002611 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 265669002612 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 265669002613 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 265669002614 active site 265669002615 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 265669002616 dimer interface [polypeptide binding]; other site 265669002617 substrate binding site [chemical binding]; other site 265669002618 catalytic residues [active] 265669002619 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 265669002620 Rsbr N terminal; Region: Rsbr_N; pfam08678 265669002621 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 265669002622 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 265669002623 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 265669002624 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 265669002625 ATP binding site [chemical binding]; other site 265669002626 Mg2+ binding site [ion binding]; other site 265669002627 G-X-G motif; other site 265669002628 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 265669002629 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 265669002630 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 265669002631 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 265669002632 anti sigma factor interaction site; other site 265669002633 regulatory phosphorylation site [posttranslational modification]; other site 265669002634 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 265669002635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669002636 ATP binding site [chemical binding]; other site 265669002637 Mg2+ binding site [ion binding]; other site 265669002638 G-X-G motif; other site 265669002639 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 265669002640 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 265669002641 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 265669002642 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 265669002643 DNA binding residues [nucleotide binding] 265669002644 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 265669002645 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 265669002646 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 265669002647 Sulfate transporter family; Region: Sulfate_transp; pfam00916 265669002648 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 265669002649 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 265669002650 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 265669002651 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 265669002652 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 265669002653 RNA binding site [nucleotide binding]; other site 265669002654 hypothetical protein; Provisional; Region: PRK04351 265669002655 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 265669002656 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 265669002657 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 265669002658 Uncharacterized conserved protein [Function unknown]; Region: COG5646 265669002659 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 265669002660 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 265669002661 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 265669002662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669002663 DNA-binding site [nucleotide binding]; DNA binding site 265669002664 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 265669002665 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 265669002666 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 265669002667 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 265669002668 glutathione reductase; Validated; Region: PRK06116 265669002669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 265669002670 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 265669002671 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 265669002672 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 265669002673 catalytic core [active] 265669002674 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 265669002675 Domain of unknown function DUF20; Region: UPF0118; pfam01594 265669002676 Predicted transcriptional regulators [Transcription]; Region: COG1725 265669002677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669002678 DNA-binding site [nucleotide binding]; DNA binding site 265669002679 Predicted membrane protein [General function prediction only]; Region: COG4194 265669002680 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 265669002681 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 265669002682 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 265669002683 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 265669002684 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 265669002685 tetramerization interface [polypeptide binding]; other site 265669002686 NAD(P) binding site [chemical binding]; other site 265669002687 catalytic residues [active] 265669002688 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 265669002689 active site 265669002690 P-loop; other site 265669002691 phosphorylation site [posttranslational modification] 265669002692 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 265669002693 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 265669002694 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 265669002695 methionine cluster; other site 265669002696 active site 265669002697 phosphorylation site [posttranslational modification] 265669002698 metal binding site [ion binding]; metal-binding site 265669002699 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 265669002700 beta-galactosidase; Region: BGL; TIGR03356 265669002701 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 265669002702 Mga helix-turn-helix domain; Region: Mga; pfam05043 265669002703 PRD domain; Region: PRD; pfam00874 265669002704 PRD domain; Region: PRD; pfam00874 265669002705 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669002706 active site 265669002707 phosphorylation site [posttranslational modification] 265669002708 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 265669002709 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 265669002710 ABC transporter; Region: ABC_tran_2; pfam12848 265669002711 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 265669002712 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 265669002713 Predicted permeases [General function prediction only]; Region: COG0701 265669002714 Predicted membrane protein [Function unknown]; Region: COG3689 265669002715 pantothenate kinase; Provisional; Region: PRK05439 265669002716 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 265669002717 ATP-binding site [chemical binding]; other site 265669002718 CoA-binding site [chemical binding]; other site 265669002719 Mg2+-binding site [ion binding]; other site 265669002720 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 265669002721 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 265669002722 Walker A/P-loop; other site 265669002723 ATP binding site [chemical binding]; other site 265669002724 Q-loop/lid; other site 265669002725 ABC transporter signature motif; other site 265669002726 Walker B; other site 265669002727 D-loop; other site 265669002728 H-loop/switch region; other site 265669002729 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 265669002730 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 265669002731 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 265669002732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 265669002733 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 265669002734 Domain of unknown function (DUF373); Region: DUF373; cl12079 265669002735 Sulfatase; Region: Sulfatase; pfam00884 265669002736 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 265669002737 active site 265669002738 DNA binding site [nucleotide binding] 265669002739 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 265669002740 active site 265669002741 catalytic site [active] 265669002742 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 265669002743 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 265669002744 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 265669002745 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 265669002746 Uncharacterized conserved protein [Function unknown]; Region: COG0398 265669002747 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 265669002748 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 265669002749 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 265669002750 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 265669002751 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 265669002752 dimer interface [polypeptide binding]; other site 265669002753 FMN binding site [chemical binding]; other site 265669002754 NADPH bind site [chemical binding]; other site 265669002755 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 265669002756 Low molecular weight phosphatase family; Region: LMWPc; cd00115 265669002757 active site 265669002758 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 265669002759 HSP90 family protein; Provisional; Region: PRK14083 265669002760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669002761 ATP binding site [chemical binding]; other site 265669002762 Mg2+ binding site [ion binding]; other site 265669002763 G-X-G motif; other site 265669002764 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 265669002765 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 265669002766 dimerization interface [polypeptide binding]; other site 265669002767 DPS ferroxidase diiron center [ion binding]; other site 265669002768 ion pore; other site 265669002769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 265669002770 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 265669002771 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 265669002772 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 265669002773 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 265669002774 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 265669002775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669002776 putative substrate translocation pore; other site 265669002777 Transcriptional regulators [Transcription]; Region: FadR; COG2186 265669002778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669002779 DNA-binding site [nucleotide binding]; DNA binding site 265669002780 FCD domain; Region: FCD; pfam07729 265669002781 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 265669002782 Domain of unknown function DUF20; Region: UPF0118; pfam01594 265669002783 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 265669002784 PGAP1-like protein; Region: PGAP1; pfam07819 265669002785 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 265669002786 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 265669002787 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 265669002788 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 265669002789 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 265669002790 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 265669002791 active site 265669002792 dimer interface [polypeptide binding]; other site 265669002793 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 265669002794 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 265669002795 active site 265669002796 trimer interface [polypeptide binding]; other site 265669002797 allosteric site; other site 265669002798 active site lid [active] 265669002799 hexamer (dimer of trimers) interface [polypeptide binding]; other site 265669002800 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 265669002801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669002802 DNA-binding site [nucleotide binding]; DNA binding site 265669002803 UTRA domain; Region: UTRA; pfam07702 265669002804 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 265669002805 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 265669002806 Mg++ binding site [ion binding]; other site 265669002807 putative catalytic motif [active] 265669002808 substrate binding site [chemical binding]; other site 265669002809 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 265669002810 Peptidase family U32; Region: Peptidase_U32; pfam01136 265669002811 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 265669002812 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 265669002813 Peptidase family U32; Region: Peptidase_U32; pfam01136 265669002814 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 265669002815 heat shock protein HtpX; Provisional; Region: PRK04897 265669002816 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 265669002817 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 265669002818 catalytic residues [active] 265669002819 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 265669002820 putative active site [active] 265669002821 putative metal binding residues [ion binding]; other site 265669002822 signature motif; other site 265669002823 putative triphosphate binding site [ion binding]; other site 265669002824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 265669002825 TPR motif; other site 265669002826 binding surface 265669002827 Tetratrico peptide repeat; Region: TPR_5; pfam12688 265669002828 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 265669002829 synthetase active site [active] 265669002830 NTP binding site [chemical binding]; other site 265669002831 metal binding site [ion binding]; metal-binding site 265669002832 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 265669002833 ATP-NAD kinase; Region: NAD_kinase; pfam01513 265669002834 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 265669002835 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 265669002836 active site 265669002837 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 265669002838 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 265669002839 NAD binding site [chemical binding]; other site 265669002840 homotetramer interface [polypeptide binding]; other site 265669002841 homodimer interface [polypeptide binding]; other site 265669002842 substrate binding site [chemical binding]; other site 265669002843 active site 265669002844 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 265669002845 DltD N-terminal region; Region: DltD_N; pfam04915 265669002846 DltD central region; Region: DltD_M; pfam04918 265669002847 DltD C-terminal region; Region: DltD_C; pfam04914 265669002848 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 265669002849 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 265669002850 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 265669002851 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 265669002852 acyl-activating enzyme (AAE) consensus motif; other site 265669002853 AMP binding site [chemical binding]; other site 265669002854 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 265669002855 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 265669002856 tetramer (dimer of dimers) interface [polypeptide binding]; other site 265669002857 active site 265669002858 dimer interface [polypeptide binding]; other site 265669002859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669002860 Coenzyme A binding pocket [chemical binding]; other site 265669002861 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 265669002862 Putative esterase; Region: Esterase; pfam00756 265669002863 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 265669002864 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 265669002865 homodimer interface [polypeptide binding]; other site 265669002866 substrate-cofactor binding pocket; other site 265669002867 catalytic residue [active] 265669002868 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 265669002869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669002870 Walker A/P-loop; other site 265669002871 ATP binding site [chemical binding]; other site 265669002872 Q-loop/lid; other site 265669002873 ABC transporter signature motif; other site 265669002874 Walker B; other site 265669002875 D-loop; other site 265669002876 H-loop/switch region; other site 265669002877 ABC-2 type transporter; Region: ABC2_membrane; cl17235 265669002878 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 265669002879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669002880 Major Facilitator Superfamily; Region: MFS_1; pfam07690 265669002881 putative substrate translocation pore; other site 265669002882 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 265669002883 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 265669002884 putative oligomer interface [polypeptide binding]; other site 265669002885 putative active site [active] 265669002886 metal binding site [ion binding]; metal-binding site 265669002887 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 265669002888 catalytic residues [active] 265669002889 dimer interface [polypeptide binding]; other site 265669002890 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 265669002891 LytTr DNA-binding domain; Region: LytTR; pfam04397 265669002892 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 265669002893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669002894 Walker A/P-loop; other site 265669002895 ATP binding site [chemical binding]; other site 265669002896 Q-loop/lid; other site 265669002897 ABC transporter signature motif; other site 265669002898 Walker B; other site 265669002899 D-loop; other site 265669002900 H-loop/switch region; other site 265669002901 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 265669002902 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 265669002903 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 265669002904 G1 box; other site 265669002905 putative GEF interaction site [polypeptide binding]; other site 265669002906 GTP/Mg2+ binding site [chemical binding]; other site 265669002907 Switch I region; other site 265669002908 G2 box; other site 265669002909 G3 box; other site 265669002910 Switch II region; other site 265669002911 G4 box; other site 265669002912 G5 box; other site 265669002913 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 265669002914 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 265669002915 MarR family; Region: MarR_2; cl17246 265669002916 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 265669002917 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 265669002918 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 265669002919 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 265669002920 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 265669002921 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 265669002922 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 265669002923 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 265669002924 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 265669002925 DNA binding site [nucleotide binding] 265669002926 active site 265669002927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669002928 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 265669002929 Walker A motif; other site 265669002930 ATP binding site [chemical binding]; other site 265669002931 Walker B motif; other site 265669002932 arginine finger; other site 265669002933 UvrB/uvrC motif; Region: UVR; pfam02151 265669002934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669002935 Walker A motif; other site 265669002936 ATP binding site [chemical binding]; other site 265669002937 Walker B motif; other site 265669002938 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 265669002939 CAAX protease self-immunity; Region: Abi; pfam02517 265669002940 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 265669002941 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 265669002942 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 265669002943 nucleotide binding site [chemical binding]; other site 265669002944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 265669002945 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 265669002946 dimerization domain swap beta strand [polypeptide binding]; other site 265669002947 regulatory protein interface [polypeptide binding]; other site 265669002948 active site 265669002949 regulatory phosphorylation site [posttranslational modification]; other site 265669002950 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 265669002951 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 265669002952 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 265669002953 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 265669002954 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 265669002955 Uncharacterized conserved protein [Function unknown]; Region: COG1434 265669002956 putative active site [active] 265669002957 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 265669002958 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 265669002959 aminotransferase A; Validated; Region: PRK07683 265669002960 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 265669002961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669002962 homodimer interface [polypeptide binding]; other site 265669002963 catalytic residue [active] 265669002964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 265669002965 FOG: CBS domain [General function prediction only]; Region: COG0517 265669002966 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 265669002967 Transcriptional regulator [Transcription]; Region: LysR; COG0583 265669002968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 265669002969 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 265669002970 dimerization interface [polypeptide binding]; other site 265669002971 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 265669002972 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 265669002973 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 265669002974 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 265669002975 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 265669002976 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 265669002977 metal binding site [ion binding]; metal-binding site 265669002978 putative dimer interface [polypeptide binding]; other site 265669002979 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 265669002980 Mechanosensitive ion channel; Region: MS_channel; pfam00924 265669002981 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 265669002982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669002983 Walker A/P-loop; other site 265669002984 ATP binding site [chemical binding]; other site 265669002985 Q-loop/lid; other site 265669002986 ABC transporter signature motif; other site 265669002987 Walker B; other site 265669002988 D-loop; other site 265669002989 H-loop/switch region; other site 265669002990 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 265669002991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669002992 dimer interface [polypeptide binding]; other site 265669002993 conserved gate region; other site 265669002994 putative PBP binding loops; other site 265669002995 ABC-ATPase subunit interface; other site 265669002996 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 265669002997 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 265669002998 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 265669002999 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 265669003000 HPr interaction site; other site 265669003001 glycerol kinase (GK) interaction site [polypeptide binding]; other site 265669003002 active site 265669003003 phosphorylation site [posttranslational modification] 265669003004 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 265669003005 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 265669003006 S1 domain; Region: S1_2; pfam13509 265669003007 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 265669003008 RNA binding site [nucleotide binding]; other site 265669003009 Predicted membrane protein [Function unknown]; Region: COG4758 265669003010 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 265669003011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 265669003012 Histidine kinase; Region: HisKA_3; pfam07730 265669003013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669003014 ATP binding site [chemical binding]; other site 265669003015 Mg2+ binding site [ion binding]; other site 265669003016 G-X-G motif; other site 265669003017 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 265669003018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669003019 active site 265669003020 phosphorylation site [posttranslational modification] 265669003021 intermolecular recognition site; other site 265669003022 dimerization interface [polypeptide binding]; other site 265669003023 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 265669003024 DNA binding residues [nucleotide binding] 265669003025 dimerization interface [polypeptide binding]; other site 265669003026 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 265669003027 TrkA-N domain; Region: TrkA_N; pfam02254 265669003028 TrkA-C domain; Region: TrkA_C; pfam02080 265669003029 Predicted membrane protein [Function unknown]; Region: COG1289 265669003030 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 265669003031 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 265669003032 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 265669003033 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 265669003034 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 265669003035 hypothetical protein; Provisional; Region: PRK13667 265669003036 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 265669003037 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669003038 active site 265669003039 motif I; other site 265669003040 motif II; other site 265669003041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669003042 Transcriptional regulators [Transcription]; Region: PurR; COG1609 265669003043 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 265669003044 DNA binding site [nucleotide binding] 265669003045 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 265669003046 ligand binding site [chemical binding]; other site 265669003047 dimerization interface [polypeptide binding]; other site 265669003048 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 265669003049 hexamer (dimer of trimers) interface [polypeptide binding]; other site 265669003050 trimer interface [polypeptide binding]; other site 265669003051 substrate binding site [chemical binding]; other site 265669003052 Mn binding site [ion binding]; other site 265669003053 transketolase; Reviewed; Region: PRK05899 265669003054 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 265669003055 TPP-binding site [chemical binding]; other site 265669003056 dimer interface [polypeptide binding]; other site 265669003057 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 265669003058 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 265669003059 PYR/PP interface [polypeptide binding]; other site 265669003060 dimer interface [polypeptide binding]; other site 265669003061 TPP binding site [chemical binding]; other site 265669003062 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 265669003063 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 265669003064 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 265669003065 nucleotide binding site [chemical binding]; other site 265669003066 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 265669003067 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 265669003068 active site turn [active] 265669003069 phosphorylation site [posttranslational modification] 265669003070 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 265669003071 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 265669003072 HPr interaction site; other site 265669003073 glycerol kinase (GK) interaction site [polypeptide binding]; other site 265669003074 active site 265669003075 phosphorylation site [posttranslational modification] 265669003076 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 265669003077 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 265669003078 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 265669003079 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 265669003080 GTP binding site; other site 265669003081 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 265669003082 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 265669003083 Walker A/P-loop; other site 265669003084 ATP binding site [chemical binding]; other site 265669003085 Q-loop/lid; other site 265669003086 ABC transporter signature motif; other site 265669003087 Walker B; other site 265669003088 D-loop; other site 265669003089 H-loop/switch region; other site 265669003090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669003091 dimer interface [polypeptide binding]; other site 265669003092 conserved gate region; other site 265669003093 putative PBP binding loops; other site 265669003094 ABC-ATPase subunit interface; other site 265669003095 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 265669003096 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 265669003097 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 265669003098 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 265669003099 dimer interface [polypeptide binding]; other site 265669003100 putative functional site; other site 265669003101 putative MPT binding site; other site 265669003102 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 265669003103 Walker A motif; other site 265669003104 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 265669003105 MoaE homodimer interface [polypeptide binding]; other site 265669003106 MoaD interaction [polypeptide binding]; other site 265669003107 active site residues [active] 265669003108 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 265669003109 MoaE interaction surface [polypeptide binding]; other site 265669003110 MoeB interaction surface [polypeptide binding]; other site 265669003111 thiocarboxylated glycine; other site 265669003112 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 265669003113 trimer interface [polypeptide binding]; other site 265669003114 dimer interface [polypeptide binding]; other site 265669003115 putative active site [active] 265669003116 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 265669003117 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 265669003118 FeS/SAM binding site; other site 265669003119 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 265669003120 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 265669003121 MPT binding site; other site 265669003122 trimer interface [polypeptide binding]; other site 265669003123 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 265669003124 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 265669003125 ATP binding site [chemical binding]; other site 265669003126 substrate interface [chemical binding]; other site 265669003127 Flavin Reductases; Region: FlaRed; cl00801 265669003128 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 265669003129 active site 265669003130 catalytic residues [active] 265669003131 metal binding site [ion binding]; metal-binding site 265669003132 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 265669003133 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 265669003134 TPP-binding site [chemical binding]; other site 265669003135 tetramer interface [polypeptide binding]; other site 265669003136 heterodimer interface [polypeptide binding]; other site 265669003137 phosphorylation loop region [posttranslational modification] 265669003138 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 265669003139 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 265669003140 alpha subunit interface [polypeptide binding]; other site 265669003141 TPP binding site [chemical binding]; other site 265669003142 heterodimer interface [polypeptide binding]; other site 265669003143 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 265669003144 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 265669003145 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 265669003146 E3 interaction surface; other site 265669003147 lipoyl attachment site [posttranslational modification]; other site 265669003148 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 265669003149 E3 interaction surface; other site 265669003150 lipoyl attachment site [posttranslational modification]; other site 265669003151 e3 binding domain; Region: E3_binding; pfam02817 265669003152 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 265669003153 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 265669003154 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 265669003155 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 265669003156 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 265669003157 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 265669003158 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 265669003159 NAD(P) binding site [chemical binding]; other site 265669003160 LDH/MDH dimer interface [polypeptide binding]; other site 265669003161 substrate binding site [chemical binding]; other site 265669003162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476 265669003163 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 265669003164 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 265669003165 catalytic residues [active] 265669003166 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 265669003167 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 265669003168 Cl binding site [ion binding]; other site 265669003169 oligomer interface [polypeptide binding]; other site 265669003170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 265669003171 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 265669003172 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 265669003173 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 265669003174 active site 265669003175 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 265669003176 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 265669003177 G1 box; other site 265669003178 putative GEF interaction site [polypeptide binding]; other site 265669003179 GTP/Mg2+ binding site [chemical binding]; other site 265669003180 Switch I region; other site 265669003181 G2 box; other site 265669003182 G3 box; other site 265669003183 Switch II region; other site 265669003184 G4 box; other site 265669003185 G5 box; other site 265669003186 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 265669003187 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 265669003188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 265669003189 hypothetical protein; Provisional; Region: PRK13666 265669003190 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 265669003191 pyruvate carboxylase; Reviewed; Region: PRK12999 265669003192 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 265669003193 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 265669003194 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 265669003195 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 265669003196 active site 265669003197 catalytic residues [active] 265669003198 metal binding site [ion binding]; metal-binding site 265669003199 homodimer binding site [polypeptide binding]; other site 265669003200 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 265669003201 carboxyltransferase (CT) interaction site; other site 265669003202 biotinylation site [posttranslational modification]; other site 265669003203 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 265669003204 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 265669003205 putative binding site residues; other site 265669003206 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 265669003207 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 265669003208 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 265669003209 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 265669003210 Walker A/P-loop; other site 265669003211 ATP binding site [chemical binding]; other site 265669003212 Q-loop/lid; other site 265669003213 ABC transporter signature motif; other site 265669003214 Walker B; other site 265669003215 D-loop; other site 265669003216 H-loop/switch region; other site 265669003217 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 265669003218 SH3-like domain; Region: SH3_8; pfam13457 265669003219 SH3-like domain; Region: SH3_8; pfam13457 265669003220 SH3-like domain; Region: SH3_8; pfam13457 265669003221 SH3-like domain; Region: SH3_8; pfam13457 265669003222 SH3-like domain; Region: SH3_8; pfam13457 265669003223 SH3-like domain; Region: SH3_8; pfam13457 265669003224 SH3-like domain; Region: SH3_8; pfam13457 265669003225 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 265669003226 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 265669003227 Ligand binding site; other site 265669003228 Putative Catalytic site; other site 265669003229 DXD motif; other site 265669003230 conserved hypothetical integral membrane protein; Region: TIGR03766 265669003231 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 265669003232 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 265669003233 active site 265669003234 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 265669003235 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 265669003236 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 265669003237 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 265669003238 active site 265669003239 tetramer interface; other site 265669003240 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 265669003241 substrate binding site; other site 265669003242 dimer interface; other site 265669003243 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 265669003244 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 265669003245 putative NAD(P) binding site [chemical binding]; other site 265669003246 putative catalytic Zn binding site [ion binding]; other site 265669003247 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 265669003248 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 265669003249 active site 265669003250 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 265669003251 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 265669003252 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 265669003253 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 265669003254 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 265669003255 active site 265669003256 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 265669003257 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 265669003258 active site 265669003259 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 265669003260 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 265669003261 homodimer interface [polypeptide binding]; other site 265669003262 NAD binding pocket [chemical binding]; other site 265669003263 ATP binding pocket [chemical binding]; other site 265669003264 Mg binding site [ion binding]; other site 265669003265 active-site loop [active] 265669003266 Uncharacterized conserved protein [Function unknown]; Region: COG1359 265669003267 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 265669003268 active site 265669003269 P-loop; other site 265669003270 phosphorylation site [posttranslational modification] 265669003271 GMP synthase; Reviewed; Region: guaA; PRK00074 265669003272 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 265669003273 AMP/PPi binding site [chemical binding]; other site 265669003274 candidate oxyanion hole; other site 265669003275 catalytic triad [active] 265669003276 potential glutamine specificity residues [chemical binding]; other site 265669003277 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 265669003278 ATP Binding subdomain [chemical binding]; other site 265669003279 Dimerization subdomain; other site 265669003280 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 265669003281 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 265669003282 active site 265669003283 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 265669003284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669003285 Walker A/P-loop; other site 265669003286 ATP binding site [chemical binding]; other site 265669003287 Q-loop/lid; other site 265669003288 ABC transporter signature motif; other site 265669003289 Walker B; other site 265669003290 D-loop; other site 265669003291 H-loop/switch region; other site 265669003292 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 265669003293 putative FMN binding site [chemical binding]; other site 265669003294 NADPH bind site [chemical binding]; other site 265669003295 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 265669003296 YcaO-like family; Region: YcaO; pfam02624 265669003297 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 265669003298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 265669003299 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 265669003300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 265669003301 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 265669003302 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 265669003303 active site 265669003304 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 265669003305 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 265669003306 MepB protein; Region: MepB; cl01985 265669003307 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 265669003308 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 265669003309 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 265669003310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669003311 Coenzyme A binding pocket [chemical binding]; other site 265669003312 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 265669003313 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 265669003314 DNA binding residues [nucleotide binding] 265669003315 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 265669003316 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 265669003317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669003318 Walker A/P-loop; other site 265669003319 ATP binding site [chemical binding]; other site 265669003320 Q-loop/lid; other site 265669003321 ABC transporter signature motif; other site 265669003322 Walker B; other site 265669003323 D-loop; other site 265669003324 H-loop/switch region; other site 265669003325 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 265669003326 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 265669003327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669003328 Walker A/P-loop; other site 265669003329 ATP binding site [chemical binding]; other site 265669003330 Q-loop/lid; other site 265669003331 ABC transporter signature motif; other site 265669003332 Walker B; other site 265669003333 D-loop; other site 265669003334 H-loop/switch region; other site 265669003335 Uncharacterized conserved protein [Function unknown]; Region: COG1359 265669003336 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 265669003337 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 265669003338 DNA binding residues [nucleotide binding] 265669003339 putative dimer interface [polypeptide binding]; other site 265669003340 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 265669003341 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 265669003342 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 265669003343 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 265669003344 LRR adjacent; Region: LRR_adjacent; pfam08191 265669003345 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669003346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 265669003347 Clp protease; Region: CLP_protease; pfam00574 265669003348 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 265669003349 oligomer interface [polypeptide binding]; other site 265669003350 active site residues [active] 265669003351 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 265669003352 dimer interface [polypeptide binding]; other site 265669003353 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 265669003354 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 265669003355 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 265669003356 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 265669003357 SLBB domain; Region: SLBB; pfam10531 265669003358 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 265669003359 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 265669003360 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 265669003361 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 265669003362 putative hexamer interface [polypeptide binding]; other site 265669003363 putative hexagonal pore; other site 265669003364 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 265669003365 putative hexamer interface [polypeptide binding]; other site 265669003366 putative hexagonal pore; other site 265669003367 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 265669003368 putative hexamer interface [polypeptide binding]; other site 265669003369 putative hexagonal pore; other site 265669003370 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 265669003371 G1 box; other site 265669003372 GTP/Mg2+ binding site [chemical binding]; other site 265669003373 G2 box; other site 265669003374 Switch I region; other site 265669003375 G3 box; other site 265669003376 Switch II region; other site 265669003377 G4 box; other site 265669003378 G5 box; other site 265669003379 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 265669003380 homotrimer interface [polypeptide binding]; other site 265669003381 Walker A motif; other site 265669003382 GTP binding site [chemical binding]; other site 265669003383 Walker B motif; other site 265669003384 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 265669003385 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 265669003386 catalytic core [active] 265669003387 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 265669003388 Sensory domain found in PocR; Region: PocR; pfam10114 265669003389 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 265669003390 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 265669003391 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 265669003392 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 265669003393 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 265669003394 Hexamer interface [polypeptide binding]; other site 265669003395 Hexagonal pore residue; other site 265669003396 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816 265669003397 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 265669003398 putative hexamer interface [polypeptide binding]; other site 265669003399 putative hexagonal pore; other site 265669003400 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 265669003401 putative hexamer interface [polypeptide binding]; other site 265669003402 putative hexagonal pore; other site 265669003403 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 265669003404 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 265669003405 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 265669003406 alpha-beta subunit interface [polypeptide binding]; other site 265669003407 alpha-gamma subunit interface [polypeptide binding]; other site 265669003408 active site 265669003409 substrate and K+ binding site; other site 265669003410 K+ binding site [ion binding]; other site 265669003411 cobalamin binding site [chemical binding]; other site 265669003412 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 265669003413 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 265669003414 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 265669003415 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 265669003416 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 265669003417 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 265669003418 putative hexamer interface [polypeptide binding]; other site 265669003419 putative hexagonal pore; other site 265669003420 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 265669003421 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 265669003422 Hexamer interface [polypeptide binding]; other site 265669003423 Hexagonal pore residue; other site 265669003424 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 265669003425 Propanediol utilisation protein PduL; Region: PduL; pfam06130 265669003426 Propanediol utilisation protein PduL; Region: PduL; pfam06130 265669003427 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 265669003428 Cell division protein FtsA; Region: FtsA; cl17206 265669003429 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 265669003430 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 265669003431 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 265669003432 Hexamer/Pentamer interface [polypeptide binding]; other site 265669003433 central pore; other site 265669003434 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 265669003435 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 265669003436 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 265669003437 putative catalytic cysteine [active] 265669003438 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 265669003439 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 265669003440 putative active site [active] 265669003441 metal binding site [ion binding]; metal-binding site 265669003442 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 265669003443 amphipathic channel; other site 265669003444 Asn-Pro-Ala signature motifs; other site 265669003445 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 265669003446 propionate/acetate kinase; Provisional; Region: PRK12379 265669003447 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 265669003448 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 265669003449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669003450 homodimer interface [polypeptide binding]; other site 265669003451 catalytic residue [active] 265669003452 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 265669003453 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 265669003454 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 265669003455 putative active site [active] 265669003456 metal binding site [ion binding]; metal-binding site 265669003457 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 265669003458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669003459 active site 265669003460 phosphorylation site [posttranslational modification] 265669003461 intermolecular recognition site; other site 265669003462 dimerization interface [polypeptide binding]; other site 265669003463 ANTAR domain; Region: ANTAR; pfam03861 265669003464 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 265669003465 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 265669003466 Histidine kinase; Region: HisKA_2; pfam07568 265669003467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669003468 ATP binding site [chemical binding]; other site 265669003469 Mg2+ binding site [ion binding]; other site 265669003470 G-X-G motif; other site 265669003471 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 265669003472 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 265669003473 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 265669003474 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 265669003475 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 265669003476 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 265669003477 putative hexamer interface [polypeptide binding]; other site 265669003478 putative hexagonal pore; other site 265669003479 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 265669003480 putative hexamer interface [polypeptide binding]; other site 265669003481 putative hexagonal pore; other site 265669003482 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 265669003483 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 265669003484 Hexamer interface [polypeptide binding]; other site 265669003485 Hexagonal pore residue; other site 265669003486 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 265669003487 putative catalytic cysteine [active] 265669003488 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 265669003489 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 265669003490 Hexamer interface [polypeptide binding]; other site 265669003491 Putative hexagonal pore residue; other site 265669003492 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 265669003493 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 265669003494 Propanediol utilisation protein PduL; Region: PduL; pfam06130 265669003495 Propanediol utilisation protein PduL; Region: PduL; pfam06130 265669003496 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 265669003497 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 265669003498 Hexamer/Pentamer interface [polypeptide binding]; other site 265669003499 central pore; other site 265669003500 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 265669003501 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 265669003502 putative hexamer interface [polypeptide binding]; other site 265669003503 putative hexagonal pore; other site 265669003504 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 265669003505 putative hexamer interface [polypeptide binding]; other site 265669003506 putative hexagonal pore; other site 265669003507 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 265669003508 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 265669003509 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 265669003510 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 265669003511 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 265669003512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 265669003513 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 265669003514 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 265669003515 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 265669003516 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 265669003517 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 265669003518 catalytic triad [active] 265669003519 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 265669003520 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 265669003521 Precorrin-8X methylmutase; Region: CbiC; pfam02570 265669003522 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 265669003523 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 265669003524 active site 265669003525 putative homodimer interface [polypeptide binding]; other site 265669003526 SAM binding site [chemical binding]; other site 265669003527 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 265669003528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669003529 S-adenosylmethionine binding site [chemical binding]; other site 265669003530 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 265669003531 active site 265669003532 SAM binding site [chemical binding]; other site 265669003533 homodimer interface [polypeptide binding]; other site 265669003534 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 265669003535 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 265669003536 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 265669003537 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 265669003538 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 265669003539 active site 265669003540 SAM binding site [chemical binding]; other site 265669003541 homodimer interface [polypeptide binding]; other site 265669003542 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 265669003543 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 265669003544 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 265669003545 active site 265669003546 SAM binding site [chemical binding]; other site 265669003547 homodimer interface [polypeptide binding]; other site 265669003548 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 265669003549 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 265669003550 active site 265669003551 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 265669003552 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 265669003553 active site 265669003554 C-terminal domain interface [polypeptide binding]; other site 265669003555 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 265669003556 active site 265669003557 N-terminal domain interface [polypeptide binding]; other site 265669003558 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 265669003559 active site 265669003560 SAM binding site [chemical binding]; other site 265669003561 homodimer interface [polypeptide binding]; other site 265669003562 cobalt transport protein CbiM; Validated; Region: PRK08319 265669003563 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 265669003564 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 265669003565 cobalt transport protein CbiQ; Provisional; Region: PRK15485 265669003566 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 265669003567 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 265669003568 Walker A/P-loop; other site 265669003569 ATP binding site [chemical binding]; other site 265669003570 Q-loop/lid; other site 265669003571 ABC transporter signature motif; other site 265669003572 Walker B; other site 265669003573 D-loop; other site 265669003574 H-loop/switch region; other site 265669003575 cobyric acid synthase; Provisional; Region: PRK00784 265669003576 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 265669003577 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 265669003578 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 265669003579 catalytic triad [active] 265669003580 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 265669003581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 265669003582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 265669003583 AAA domain; Region: AAA_17; cl17253 265669003584 Predicted transcriptional regulators [Transcription]; Region: COG1695 265669003585 Transcriptional regulator PadR-like family; Region: PadR; cl17335 265669003586 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 265669003587 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 265669003588 SH3-like domain; Region: SH3_8; pfam13457 265669003589 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 265669003590 SH3-like domain; Region: SH3_8; pfam13457 265669003591 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 265669003592 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 265669003593 oligomer interface [polypeptide binding]; other site 265669003594 active site 265669003595 metal binding site [ion binding]; metal-binding site 265669003596 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 265669003597 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 265669003598 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 265669003599 Predicted transcriptional regulators [Transcription]; Region: COG1733 265669003600 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 265669003601 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 265669003602 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 265669003603 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 265669003604 dimer interface [polypeptide binding]; other site 265669003605 motif 1; other site 265669003606 active site 265669003607 motif 2; other site 265669003608 motif 3; other site 265669003609 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 265669003610 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 265669003611 putative tRNA-binding site [nucleotide binding]; other site 265669003612 B3/4 domain; Region: B3_4; pfam03483 265669003613 tRNA synthetase B5 domain; Region: B5; smart00874 265669003614 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 265669003615 dimer interface [polypeptide binding]; other site 265669003616 motif 1; other site 265669003617 motif 3; other site 265669003618 motif 2; other site 265669003619 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 265669003620 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 265669003621 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 265669003622 Walker A/P-loop; other site 265669003623 ATP binding site [chemical binding]; other site 265669003624 Q-loop/lid; other site 265669003625 ABC transporter signature motif; other site 265669003626 Walker B; other site 265669003627 D-loop; other site 265669003628 H-loop/switch region; other site 265669003629 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 265669003630 FtsX-like permease family; Region: FtsX; pfam02687 265669003631 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 265669003632 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 265669003633 FtsX-like permease family; Region: FtsX; pfam02687 265669003634 Transcriptional regulators [Transcription]; Region: MarR; COG1846 265669003635 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 265669003636 putative DNA binding site [nucleotide binding]; other site 265669003637 putative Zn2+ binding site [ion binding]; other site 265669003638 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 265669003639 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 265669003640 ligand binding site [chemical binding]; other site 265669003641 active site 265669003642 UGI interface [polypeptide binding]; other site 265669003643 catalytic site [active] 265669003644 ribonuclease HIII; Provisional; Region: PRK00996 265669003645 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 265669003646 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 265669003647 RNA/DNA hybrid binding site [nucleotide binding]; other site 265669003648 active site 265669003649 Cell division protein ZapA; Region: ZapA; cl01146 265669003650 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 265669003651 Colicin V production protein; Region: Colicin_V; pfam02674 265669003652 hypothetical protein; Provisional; Region: PRK08609 265669003653 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 265669003654 active site 265669003655 primer binding site [nucleotide binding]; other site 265669003656 NTP binding site [chemical binding]; other site 265669003657 metal binding triad [ion binding]; metal-binding site 265669003658 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 265669003659 active site 265669003660 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 265669003661 MutS domain III; Region: MutS_III; pfam05192 265669003662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669003663 Walker A/P-loop; other site 265669003664 ATP binding site [chemical binding]; other site 265669003665 Q-loop/lid; other site 265669003666 ABC transporter signature motif; other site 265669003667 Walker B; other site 265669003668 D-loop; other site 265669003669 H-loop/switch region; other site 265669003670 Smr domain; Region: Smr; pfam01713 265669003671 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 265669003672 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 265669003673 catalytic residues [active] 265669003674 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 265669003675 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 265669003676 GIY-YIG motif/motif A; other site 265669003677 active site 265669003678 catalytic site [active] 265669003679 putative DNA binding site [nucleotide binding]; other site 265669003680 metal binding site [ion binding]; metal-binding site 265669003681 UvrB/uvrC motif; Region: UVR; pfam02151 265669003682 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 265669003683 aspartate kinase; Reviewed; Region: PRK06635 265669003684 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 265669003685 putative nucleotide binding site [chemical binding]; other site 265669003686 putative catalytic residues [active] 265669003687 putative Mg ion binding site [ion binding]; other site 265669003688 putative aspartate binding site [chemical binding]; other site 265669003689 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 265669003690 putative allosteric regulatory site; other site 265669003691 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 265669003692 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 265669003693 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 265669003694 ribonuclease PH; Reviewed; Region: rph; PRK00173 265669003695 Ribonuclease PH; Region: RNase_PH_bact; cd11362 265669003696 hexamer interface [polypeptide binding]; other site 265669003697 active site 265669003698 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 265669003699 active site 265669003700 dimerization interface [polypeptide binding]; other site 265669003701 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 265669003702 active site 265669003703 metal binding site [ion binding]; metal-binding site 265669003704 homotetramer interface [polypeptide binding]; other site 265669003705 prophage LambdaLm02; lysogenic bacteriophage region; appears to be a degenerate remnant of the unpublished Listeria monocytogenes bacteriophage PSA 265669003706 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 265669003707 Leucine rich repeat; Region: LRR_8; pfam13855 265669003708 LRR adjacent; Region: LRR_adjacent; pfam08191 265669003709 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669003710 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669003711 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669003712 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669003713 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669003714 Uncharacterized conserved protein [Function unknown]; Region: COG5361 265669003715 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 265669003716 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 265669003717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 265669003718 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 265669003719 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 265669003720 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 265669003721 dimer interface [polypeptide binding]; other site 265669003722 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 265669003723 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 265669003724 catalytic core [active] 265669003725 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 265669003726 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 265669003727 ATP binding site [chemical binding]; other site 265669003728 Mg++ binding site [ion binding]; other site 265669003729 motif III; other site 265669003730 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 265669003731 nucleotide binding region [chemical binding]; other site 265669003732 ATP-binding site [chemical binding]; other site 265669003733 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 265669003734 RNA binding site [nucleotide binding]; other site 265669003735 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 265669003736 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 265669003737 putative active site [active] 265669003738 nucleotide binding site [chemical binding]; other site 265669003739 nudix motif; other site 265669003740 putative metal binding site [ion binding]; other site 265669003741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669003742 Major Facilitator Superfamily; Region: MFS_1; pfam07690 265669003743 putative substrate translocation pore; other site 265669003744 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669003745 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 265669003746 ligand binding site [chemical binding]; other site 265669003747 flexible hinge region; other site 265669003748 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 265669003749 Uncharacterized conserved protein [Function unknown]; Region: COG1284 265669003750 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 265669003751 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 265669003752 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 265669003753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669003754 DNA-binding site [nucleotide binding]; DNA binding site 265669003755 UTRA domain; Region: UTRA; pfam07702 265669003756 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 265669003757 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 265669003758 Ca binding site [ion binding]; other site 265669003759 active site 265669003760 catalytic site [active] 265669003761 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 265669003762 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 265669003763 active site turn [active] 265669003764 phosphorylation site [posttranslational modification] 265669003765 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 265669003766 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 265669003767 nudix motif; other site 265669003768 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 265669003769 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 265669003770 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 265669003771 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 265669003772 putative catalytic cysteine [active] 265669003773 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 265669003774 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 265669003775 nucleotide binding site [chemical binding]; other site 265669003776 homotetrameric interface [polypeptide binding]; other site 265669003777 putative phosphate binding site [ion binding]; other site 265669003778 putative allosteric binding site; other site 265669003779 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 265669003780 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 265669003781 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 265669003782 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669003783 non-specific DNA binding site [nucleotide binding]; other site 265669003784 salt bridge; other site 265669003785 sequence-specific DNA binding site [nucleotide binding]; other site 265669003786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669003787 non-specific DNA binding site [nucleotide binding]; other site 265669003788 salt bridge; other site 265669003789 sequence-specific DNA binding site [nucleotide binding]; other site 265669003790 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 265669003791 active site 265669003792 trigger factor; Provisional; Region: tig; PRK01490 265669003793 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 265669003794 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 265669003795 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 265669003796 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 265669003797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669003798 Walker A motif; other site 265669003799 ATP binding site [chemical binding]; other site 265669003800 Walker B motif; other site 265669003801 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 265669003802 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 265669003803 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 265669003804 Catalytic site [active] 265669003805 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 265669003806 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 265669003807 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 265669003808 Catalytic site [active] 265669003809 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 265669003810 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 265669003811 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 265669003812 Catalytic site [active] 265669003813 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 265669003814 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 265669003815 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 265669003816 GTP/Mg2+ binding site [chemical binding]; other site 265669003817 G4 box; other site 265669003818 G5 box; other site 265669003819 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 265669003820 G1 box; other site 265669003821 G1 box; other site 265669003822 GTP/Mg2+ binding site [chemical binding]; other site 265669003823 Switch I region; other site 265669003824 G2 box; other site 265669003825 G2 box; other site 265669003826 G3 box; other site 265669003827 G3 box; other site 265669003828 Switch II region; other site 265669003829 Switch II region; other site 265669003830 G5 box; other site 265669003831 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 265669003832 RNA/DNA hybrid binding site [nucleotide binding]; other site 265669003833 active site 265669003834 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 265669003835 DNA protecting protein DprA; Region: dprA; TIGR00732 265669003836 DNA topoisomerase I; Validated; Region: PRK05582 265669003837 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 265669003838 active site 265669003839 interdomain interaction site; other site 265669003840 putative metal-binding site [ion binding]; other site 265669003841 nucleotide binding site [chemical binding]; other site 265669003842 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 265669003843 domain I; other site 265669003844 DNA binding groove [nucleotide binding] 265669003845 phosphate binding site [ion binding]; other site 265669003846 domain II; other site 265669003847 domain III; other site 265669003848 nucleotide binding site [chemical binding]; other site 265669003849 catalytic site [active] 265669003850 domain IV; other site 265669003851 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 265669003852 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 265669003853 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 265669003854 Glucose inhibited division protein A; Region: GIDA; pfam01134 265669003855 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 265669003856 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 265669003857 active site 265669003858 DNA binding site [nucleotide binding] 265669003859 Int/Topo IB signature motif; other site 265669003860 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 265669003861 active site 265669003862 HslU subunit interaction site [polypeptide binding]; other site 265669003863 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 265669003864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669003865 Walker A motif; other site 265669003866 ATP binding site [chemical binding]; other site 265669003867 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 265669003868 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 265669003869 transcriptional repressor CodY; Validated; Region: PRK04158 265669003870 CodY GAF-like domain; Region: CodY; pfam06018 265669003871 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 265669003872 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 265669003873 active site 265669003874 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 265669003875 active site 265669003876 catalytic residues [active] 265669003877 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 265669003878 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 265669003879 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 265669003880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669003881 Mg2+ binding site [ion binding]; other site 265669003882 G-X-G motif; other site 265669003883 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 265669003884 anchoring element; other site 265669003885 dimer interface [polypeptide binding]; other site 265669003886 ATP binding site [chemical binding]; other site 265669003887 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 265669003888 active site 265669003889 putative metal-binding site [ion binding]; other site 265669003890 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 265669003891 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 265669003892 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 265669003893 CAP-like domain; other site 265669003894 active site 265669003895 primary dimer interface [polypeptide binding]; other site 265669003896 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 265669003897 S-ribosylhomocysteinase; Provisional; Region: PRK02260 265669003898 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 265669003899 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669003900 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 265669003901 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 265669003902 catalytic triad [active] 265669003903 catalytic triad [active] 265669003904 oxyanion hole [active] 265669003905 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 265669003906 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 265669003907 active site 265669003908 catalytic site [active] 265669003909 metal binding site [ion binding]; metal-binding site 265669003910 dimer interface [polypeptide binding]; other site 265669003911 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 265669003912 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 265669003913 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 265669003914 bacterial Hfq-like; Region: Hfq; cd01716 265669003915 hexamer interface [polypeptide binding]; other site 265669003916 Sm1 motif; other site 265669003917 RNA binding site [nucleotide binding]; other site 265669003918 Sm2 motif; other site 265669003919 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 265669003920 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 265669003921 HflX GTPase family; Region: HflX; cd01878 265669003922 G1 box; other site 265669003923 GTP/Mg2+ binding site [chemical binding]; other site 265669003924 Switch I region; other site 265669003925 G2 box; other site 265669003926 G3 box; other site 265669003927 Switch II region; other site 265669003928 G4 box; other site 265669003929 G5 box; other site 265669003930 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 265669003931 Aluminium resistance protein; Region: Alum_res; pfam06838 265669003932 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 265669003933 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 265669003934 DNA binding residues [nucleotide binding] 265669003935 putative dimer interface [polypeptide binding]; other site 265669003936 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 265669003937 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 265669003938 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 265669003939 arsenical pump membrane protein; Provisional; Region: PRK15445 265669003940 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 265669003941 transmembrane helices; other site 265669003942 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 265669003943 LexA repressor; Validated; Region: PRK00215 265669003944 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 265669003945 putative DNA binding site [nucleotide binding]; other site 265669003946 putative Zn2+ binding site [ion binding]; other site 265669003947 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 265669003948 Catalytic site [active] 265669003949 cell division suppressor protein YneA; Provisional; Region: PRK14125 265669003950 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 265669003951 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 265669003952 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 265669003953 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 265669003954 TPP-binding site [chemical binding]; other site 265669003955 dimer interface [polypeptide binding]; other site 265669003956 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 265669003957 PYR/PP interface [polypeptide binding]; other site 265669003958 dimer interface [polypeptide binding]; other site 265669003959 TPP binding site [chemical binding]; other site 265669003960 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 265669003961 hypothetical protein; Provisional; Region: PRK01844 265669003962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 265669003963 Methyltransferase domain; Region: Methyltransf_31; pfam13847 265669003964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669003965 S-adenosylmethionine binding site [chemical binding]; other site 265669003966 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 265669003967 ParB-like nuclease domain; Region: ParBc; pfam02195 265669003968 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 265669003969 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 265669003970 Active Sites [active] 265669003971 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 265669003972 DEAD-like helicases superfamily; Region: DEXDc; smart00487 265669003973 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 265669003974 putative nucleotide binding site [chemical binding]; other site 265669003975 uridine monophosphate binding site [chemical binding]; other site 265669003976 homohexameric interface [polypeptide binding]; other site 265669003977 ribosome recycling factor; Reviewed; Region: frr; PRK00083 265669003978 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 265669003979 hinge region; other site 265669003980 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 265669003981 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 265669003982 catalytic residue [active] 265669003983 putative FPP diphosphate binding site; other site 265669003984 putative FPP binding hydrophobic cleft; other site 265669003985 dimer interface [polypeptide binding]; other site 265669003986 putative IPP diphosphate binding site; other site 265669003987 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 265669003988 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 265669003989 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 265669003990 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 265669003991 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 265669003992 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 265669003993 RIP metalloprotease RseP; Region: TIGR00054 265669003994 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 265669003995 active site 265669003996 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 265669003997 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 265669003998 protein binding site [polypeptide binding]; other site 265669003999 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 265669004000 putative substrate binding region [chemical binding]; other site 265669004001 prolyl-tRNA synthetase; Provisional; Region: PRK09194 265669004002 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 265669004003 dimer interface [polypeptide binding]; other site 265669004004 motif 1; other site 265669004005 active site 265669004006 motif 2; other site 265669004007 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 265669004008 putative deacylase active site [active] 265669004009 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 265669004010 active site 265669004011 motif 3; other site 265669004012 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 265669004013 anticodon binding site; other site 265669004014 DNA polymerase III PolC; Validated; Region: polC; PRK00448 265669004015 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 265669004016 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 265669004017 generic binding surface II; other site 265669004018 generic binding surface I; other site 265669004019 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 265669004020 active site 265669004021 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 265669004022 active site 265669004023 catalytic site [active] 265669004024 substrate binding site [chemical binding]; other site 265669004025 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 265669004026 ribosome maturation protein RimP; Reviewed; Region: PRK00092 265669004027 Sm and related proteins; Region: Sm_like; cl00259 265669004028 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 265669004029 putative oligomer interface [polypeptide binding]; other site 265669004030 putative RNA binding site [nucleotide binding]; other site 265669004031 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 265669004032 NusA N-terminal domain; Region: NusA_N; pfam08529 265669004033 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 265669004034 RNA binding site [nucleotide binding]; other site 265669004035 homodimer interface [polypeptide binding]; other site 265669004036 NusA-like KH domain; Region: KH_5; pfam13184 265669004037 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 265669004038 G-X-X-G motif; other site 265669004039 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 265669004040 putative RNA binding cleft [nucleotide binding]; other site 265669004041 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 265669004042 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 265669004043 translation initiation factor IF-2; Region: IF-2; TIGR00487 265669004044 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 265669004045 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 265669004046 G1 box; other site 265669004047 putative GEF interaction site [polypeptide binding]; other site 265669004048 GTP/Mg2+ binding site [chemical binding]; other site 265669004049 Switch I region; other site 265669004050 G2 box; other site 265669004051 G3 box; other site 265669004052 Switch II region; other site 265669004053 G4 box; other site 265669004054 G5 box; other site 265669004055 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 265669004056 Translation-initiation factor 2; Region: IF-2; pfam11987 265669004057 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 265669004058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 265669004059 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 265669004060 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 265669004061 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 265669004062 RNA binding site [nucleotide binding]; other site 265669004063 active site 265669004064 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 265669004065 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 265669004066 active site 265669004067 Riboflavin kinase; Region: Flavokinase; smart00904 265669004068 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 265669004069 16S/18S rRNA binding site [nucleotide binding]; other site 265669004070 S13e-L30e interaction site [polypeptide binding]; other site 265669004071 25S rRNA binding site [nucleotide binding]; other site 265669004072 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 265669004073 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 265669004074 RNase E interface [polypeptide binding]; other site 265669004075 trimer interface [polypeptide binding]; other site 265669004076 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 265669004077 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 265669004078 RNase E interface [polypeptide binding]; other site 265669004079 trimer interface [polypeptide binding]; other site 265669004080 active site 265669004081 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 265669004082 putative nucleic acid binding region [nucleotide binding]; other site 265669004083 G-X-X-G motif; other site 265669004084 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 265669004085 RNA binding site [nucleotide binding]; other site 265669004086 domain interface; other site 265669004087 GTPase RsgA; Reviewed; Region: PRK01889 265669004088 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 265669004089 RNA binding site [nucleotide binding]; other site 265669004090 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 265669004091 GTPase/Zn-binding domain interface [polypeptide binding]; other site 265669004092 GTP/Mg2+ binding site [chemical binding]; other site 265669004093 G4 box; other site 265669004094 G5 box; other site 265669004095 G1 box; other site 265669004096 Switch I region; other site 265669004097 G2 box; other site 265669004098 G3 box; other site 265669004099 Switch II region; other site 265669004100 YceG-like family; Region: YceG; pfam02618 265669004101 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 265669004102 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 265669004103 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 265669004104 Rhomboid family; Region: Rhomboid; pfam01694 265669004105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 265669004106 TPR motif; other site 265669004107 TPR repeat; Region: TPR_11; pfam13414 265669004108 binding surface 265669004109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 265669004110 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 265669004111 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 265669004112 nucleotide binding site [chemical binding]; other site 265669004113 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 265669004114 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 265669004115 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 265669004116 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 265669004117 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 265669004118 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 265669004119 Type II/IV secretion system protein; Region: T2SE; pfam00437 265669004120 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 265669004121 Walker A motif; other site 265669004122 ATP binding site [chemical binding]; other site 265669004123 Walker B motif; other site 265669004124 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 265669004125 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 265669004126 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 265669004127 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 265669004128 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 265669004129 tetramer interface [polypeptide binding]; other site 265669004130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669004131 catalytic residue [active] 265669004132 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 265669004133 tetramer interface [polypeptide binding]; other site 265669004134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669004135 catalytic residue [active] 265669004136 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 265669004137 active site residue [active] 265669004138 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 265669004139 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 265669004140 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 265669004141 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 265669004142 active site 265669004143 elongation factor P; Validated; Region: PRK00529 265669004144 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 265669004145 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 265669004146 RNA binding site [nucleotide binding]; other site 265669004147 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 265669004148 RNA binding site [nucleotide binding]; other site 265669004149 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 265669004150 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 265669004151 carboxyltransferase (CT) interaction site; other site 265669004152 biotinylation site [posttranslational modification]; other site 265669004153 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 265669004154 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 265669004155 ATP-grasp domain; Region: ATP-grasp_4; cl17255 265669004156 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 265669004157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 265669004158 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 265669004159 putative RNA binding site [nucleotide binding]; other site 265669004160 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 265669004161 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 265669004162 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 265669004163 homodimer interface [polypeptide binding]; other site 265669004164 NADP binding site [chemical binding]; other site 265669004165 substrate binding site [chemical binding]; other site 265669004166 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 265669004167 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 265669004168 generic binding surface II; other site 265669004169 generic binding surface I; other site 265669004170 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 265669004171 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 265669004172 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 265669004173 substrate binding pocket [chemical binding]; other site 265669004174 chain length determination region; other site 265669004175 substrate-Mg2+ binding site; other site 265669004176 catalytic residues [active] 265669004177 aspartate-rich region 1; other site 265669004178 active site lid residues [active] 265669004179 aspartate-rich region 2; other site 265669004180 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 265669004181 DNA-binding site [nucleotide binding]; DNA binding site 265669004182 RNA-binding motif; other site 265669004183 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 265669004184 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 265669004185 TPP-binding site; other site 265669004186 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 265669004187 PYR/PP interface [polypeptide binding]; other site 265669004188 dimer interface [polypeptide binding]; other site 265669004189 TPP binding site [chemical binding]; other site 265669004190 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 265669004191 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 265669004192 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 265669004193 RNA binding surface [nucleotide binding]; other site 265669004194 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 265669004195 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 265669004196 arginine repressor; Provisional; Region: PRK04280 265669004197 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 265669004198 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 265669004199 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 265669004200 Walker A/P-loop; other site 265669004201 ATP binding site [chemical binding]; other site 265669004202 Q-loop/lid; other site 265669004203 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 265669004204 ABC transporter signature motif; other site 265669004205 Walker B; other site 265669004206 D-loop; other site 265669004207 H-loop/switch region; other site 265669004208 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 265669004209 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 265669004210 nucleotide binding site [chemical binding]; other site 265669004211 Acetokinase family; Region: Acetate_kinase; cl17229 265669004212 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 265669004213 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 265669004214 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 265669004215 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 265669004216 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 265669004217 tetramer interface [polypeptide binding]; other site 265669004218 TPP-binding site [chemical binding]; other site 265669004219 heterodimer interface [polypeptide binding]; other site 265669004220 phosphorylation loop region [posttranslational modification] 265669004221 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 265669004222 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 265669004223 alpha subunit interface [polypeptide binding]; other site 265669004224 TPP binding site [chemical binding]; other site 265669004225 heterodimer interface [polypeptide binding]; other site 265669004226 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 265669004227 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 265669004228 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 265669004229 E3 interaction surface; other site 265669004230 lipoyl attachment site [posttranslational modification]; other site 265669004231 e3 binding domain; Region: E3_binding; pfam02817 265669004232 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 265669004233 peptidase T-like protein; Region: PepT-like; TIGR01883 265669004234 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 265669004235 metal binding site [ion binding]; metal-binding site 265669004236 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 265669004237 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 265669004238 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 265669004239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 265669004240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669004241 active site 265669004242 phosphorylation site [posttranslational modification] 265669004243 intermolecular recognition site; other site 265669004244 dimerization interface [polypeptide binding]; other site 265669004245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 265669004246 DNA binding site [nucleotide binding] 265669004247 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 265669004248 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 265669004249 dimerization interface [polypeptide binding]; other site 265669004250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 265669004251 dimer interface [polypeptide binding]; other site 265669004252 phosphorylation site [posttranslational modification] 265669004253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669004254 ATP binding site [chemical binding]; other site 265669004255 Mg2+ binding site [ion binding]; other site 265669004256 G-X-G motif; other site 265669004257 OxaA-like protein precursor; Validated; Region: PRK01622 265669004258 acylphosphatase; Provisional; Region: PRK14443 265669004259 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 265669004260 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 265669004261 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 265669004262 homotetramer interface [polypeptide binding]; other site 265669004263 FMN binding site [chemical binding]; other site 265669004264 homodimer contacts [polypeptide binding]; other site 265669004265 putative active site [active] 265669004266 putative substrate binding site [chemical binding]; other site 265669004267 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 265669004268 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 265669004269 active site residue [active] 265669004270 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 265669004271 Uncharacterized conserved protein [Function unknown]; Region: COG1284 265669004272 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 265669004273 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 265669004274 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 265669004275 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 265669004276 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 265669004277 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 265669004278 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 265669004279 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 265669004280 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 265669004281 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 265669004282 ligand binding site [chemical binding]; other site 265669004283 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 265669004284 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 265669004285 Walker A/P-loop; other site 265669004286 ATP binding site [chemical binding]; other site 265669004287 Q-loop/lid; other site 265669004288 ABC transporter signature motif; other site 265669004289 Walker B; other site 265669004290 D-loop; other site 265669004291 H-loop/switch region; other site 265669004292 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 265669004293 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 265669004294 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 265669004295 TM-ABC transporter signature motif; other site 265669004296 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 265669004297 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 265669004298 TM-ABC transporter signature motif; other site 265669004299 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 265669004300 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 265669004301 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 265669004302 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 265669004303 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 265669004304 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 265669004305 classical (c) SDRs; Region: SDR_c; cd05233 265669004306 NAD(P) binding site [chemical binding]; other site 265669004307 active site 265669004308 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 265669004309 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669004310 non-specific DNA binding site [nucleotide binding]; other site 265669004311 salt bridge; other site 265669004312 sequence-specific DNA binding site [nucleotide binding]; other site 265669004313 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 265669004314 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 265669004315 competence damage-inducible protein A; Provisional; Region: PRK00549 265669004316 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 265669004317 putative MPT binding site; other site 265669004318 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 265669004319 recombinase A; Provisional; Region: recA; PRK09354 265669004320 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 265669004321 hexamer interface [polypeptide binding]; other site 265669004322 Walker A motif; other site 265669004323 ATP binding site [chemical binding]; other site 265669004324 Walker B motif; other site 265669004325 phosphodiesterase; Provisional; Region: PRK12704 265669004326 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 265669004327 Zn2+ binding site [ion binding]; other site 265669004328 Mg2+ binding site [ion binding]; other site 265669004329 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 265669004330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669004331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 265669004332 Coenzyme A binding pocket [chemical binding]; other site 265669004333 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 265669004334 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 265669004335 putative active site [active] 265669004336 metal binding site [ion binding]; metal-binding site 265669004337 homodimer binding site [polypeptide binding]; other site 265669004338 Predicted membrane protein [Function unknown]; Region: COG4550 265669004339 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 265669004340 MutS domain I; Region: MutS_I; pfam01624 265669004341 MutS domain II; Region: MutS_II; pfam05188 265669004342 MutS domain III; Region: MutS_III; pfam05192 265669004343 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 265669004344 Walker A/P-loop; other site 265669004345 ATP binding site [chemical binding]; other site 265669004346 Q-loop/lid; other site 265669004347 ABC transporter signature motif; other site 265669004348 Walker B; other site 265669004349 D-loop; other site 265669004350 H-loop/switch region; other site 265669004351 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 265669004352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669004353 ATP binding site [chemical binding]; other site 265669004354 Mg2+ binding site [ion binding]; other site 265669004355 G-X-G motif; other site 265669004356 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 265669004357 ATP binding site [chemical binding]; other site 265669004358 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 265669004359 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 265669004360 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 265669004361 Pyruvate formate lyase 1; Region: PFL1; cd01678 265669004362 coenzyme A binding site [chemical binding]; other site 265669004363 active site 265669004364 catalytic residues [active] 265669004365 glycine loop; other site 265669004366 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 265669004367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 265669004368 FeS/SAM binding site; other site 265669004369 Predicted transcriptional regulators [Transcription]; Region: COG1695 265669004370 Transcriptional regulator PadR-like family; Region: PadR; cl17335 265669004371 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 265669004372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669004373 Major Facilitator Superfamily; Region: MFS_1; pfam07690 265669004374 putative substrate translocation pore; other site 265669004375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669004376 non-specific DNA binding site [nucleotide binding]; other site 265669004377 salt bridge; other site 265669004378 sequence-specific DNA binding site [nucleotide binding]; other site 265669004379 topology modulation protein; Reviewed; Region: PRK08118 265669004380 AAA domain; Region: AAA_17; pfam13207 265669004381 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669004382 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669004383 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669004384 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669004385 putative acyltransferase; Provisional; Region: PRK05790 265669004386 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 265669004387 dimer interface [polypeptide binding]; other site 265669004388 active site 265669004389 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 265669004390 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 265669004391 dimer interface [polypeptide binding]; other site 265669004392 active site 265669004393 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 265669004394 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 265669004395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669004396 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 265669004397 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 265669004398 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 265669004399 Domain of unknown function DUF20; Region: UPF0118; pfam01594 265669004400 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 265669004401 FAD binding domain; Region: FAD_binding_4; pfam01565 265669004402 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 265669004403 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 265669004404 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 265669004405 Walker A/P-loop; other site 265669004406 ATP binding site [chemical binding]; other site 265669004407 Q-loop/lid; other site 265669004408 ABC transporter signature motif; other site 265669004409 Walker B; other site 265669004410 D-loop; other site 265669004411 H-loop/switch region; other site 265669004412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669004413 dimer interface [polypeptide binding]; other site 265669004414 conserved gate region; other site 265669004415 ABC-ATPase subunit interface; other site 265669004416 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 265669004417 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 265669004418 manganese transport protein MntH; Reviewed; Region: PRK00701 265669004419 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 265669004420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669004421 dimer interface [polypeptide binding]; other site 265669004422 conserved gate region; other site 265669004423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 265669004424 ABC-ATPase subunit interface; other site 265669004425 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 265669004426 LysR substrate binding domain; Region: LysR_substrate; pfam03466 265669004427 dimerization interface [polypeptide binding]; other site 265669004428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669004429 dimer interface [polypeptide binding]; other site 265669004430 conserved gate region; other site 265669004431 putative PBP binding loops; other site 265669004432 ABC-ATPase subunit interface; other site 265669004433 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 265669004434 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 265669004435 Walker A/P-loop; other site 265669004436 ATP binding site [chemical binding]; other site 265669004437 Q-loop/lid; other site 265669004438 ABC transporter signature motif; other site 265669004439 Walker B; other site 265669004440 D-loop; other site 265669004441 H-loop/switch region; other site 265669004442 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 265669004443 Predicted membrane protein [Function unknown]; Region: COG3859 265669004444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 265669004445 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 265669004446 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 265669004447 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 265669004448 ABC transporter; Region: ABC_tran_2; pfam12848 265669004449 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 265669004450 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 265669004451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 265669004452 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 265669004453 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 265669004454 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 265669004455 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 265669004456 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 265669004457 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 265669004458 dihydrodipicolinate synthase; Region: dapA; TIGR00674 265669004459 dimer interface [polypeptide binding]; other site 265669004460 active site 265669004461 catalytic residue [active] 265669004462 aspartate kinase I; Reviewed; Region: PRK08210 265669004463 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 265669004464 nucleotide binding site [chemical binding]; other site 265669004465 substrate binding site [chemical binding]; other site 265669004466 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 265669004467 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 265669004468 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 265669004469 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 265669004470 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 265669004471 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 265669004472 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 265669004473 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 265669004474 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 265669004475 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 265669004476 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 265669004477 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 265669004478 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 265669004479 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 265669004480 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 265669004481 Predicted membrane protein [Function unknown]; Region: COG4392 265669004482 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 265669004483 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 265669004484 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 265669004485 metal binding site 2 [ion binding]; metal-binding site 265669004486 putative DNA binding helix; other site 265669004487 metal binding site 1 [ion binding]; metal-binding site 265669004488 dimer interface [polypeptide binding]; other site 265669004489 structural Zn2+ binding site [ion binding]; other site 265669004490 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 265669004491 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 265669004492 ABC-ATPase subunit interface; other site 265669004493 dimer interface [polypeptide binding]; other site 265669004494 putative PBP binding regions; other site 265669004495 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 265669004496 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 265669004497 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 265669004498 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 265669004499 DHHA2 domain; Region: DHHA2; pfam02833 265669004500 endonuclease IV; Provisional; Region: PRK01060 265669004501 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 265669004502 AP (apurinic/apyrimidinic) site pocket; other site 265669004503 DNA interaction; other site 265669004504 Metal-binding active site; metal-binding site 265669004505 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 265669004506 DEAD-like helicases superfamily; Region: DEXDc; smart00487 265669004507 ATP binding site [chemical binding]; other site 265669004508 Mg++ binding site [ion binding]; other site 265669004509 motif III; other site 265669004510 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 265669004511 nucleotide binding region [chemical binding]; other site 265669004512 ATP-binding site [chemical binding]; other site 265669004513 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 265669004514 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 265669004515 Uncharacterized conserved protein [Function unknown]; Region: COG0327 265669004516 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 265669004517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 265669004518 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 265669004519 Uncharacterized conserved protein [Function unknown]; Region: COG0327 265669004520 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 265669004521 Family of unknown function (DUF633); Region: DUF633; pfam04816 265669004522 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 265669004523 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 265669004524 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 265669004525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 265669004526 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 265669004527 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 265669004528 DNA binding residues [nucleotide binding] 265669004529 DNA primase; Validated; Region: dnaG; PRK05667 265669004530 CHC2 zinc finger; Region: zf-CHC2; pfam01807 265669004531 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 265669004532 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 265669004533 active site 265669004534 metal binding site [ion binding]; metal-binding site 265669004535 interdomain interaction site; other site 265669004536 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 265669004537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 265669004538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 265669004539 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 265669004540 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 265669004541 DALR anticodon binding domain; Region: DALR_1; pfam05746 265669004542 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 265669004543 dimer interface [polypeptide binding]; other site 265669004544 motif 1; other site 265669004545 active site 265669004546 motif 2; other site 265669004547 motif 3; other site 265669004548 DNA repair protein RecO; Region: reco; TIGR00613 265669004549 Recombination protein O N terminal; Region: RecO_N; pfam11967 265669004550 Recombination protein O C terminal; Region: RecO_C; pfam02565 265669004551 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 265669004552 GTPase Era; Reviewed; Region: era; PRK00089 265669004553 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 265669004554 G1 box; other site 265669004555 GTP/Mg2+ binding site [chemical binding]; other site 265669004556 Switch I region; other site 265669004557 G2 box; other site 265669004558 Switch II region; other site 265669004559 G3 box; other site 265669004560 G4 box; other site 265669004561 G5 box; other site 265669004562 KH domain; Region: KH_2; pfam07650 265669004563 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 265669004564 active site 265669004565 catalytic motif [active] 265669004566 Zn binding site [ion binding]; other site 265669004567 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 265669004568 metal-binding heat shock protein; Provisional; Region: PRK00016 265669004569 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 265669004570 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 265669004571 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 265669004572 Zn2+ binding site [ion binding]; other site 265669004573 Mg2+ binding site [ion binding]; other site 265669004574 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 265669004575 PhoH-like protein; Region: PhoH; pfam02562 265669004576 Yqey-like protein; Region: YqeY; pfam09424 265669004577 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 265669004578 RNA methyltransferase, RsmE family; Region: TIGR00046 265669004579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 265669004580 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 265669004581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669004582 S-adenosylmethionine binding site [chemical binding]; other site 265669004583 chaperone protein DnaJ; Provisional; Region: PRK14280 265669004584 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 265669004585 HSP70 interaction site [polypeptide binding]; other site 265669004586 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 265669004587 substrate binding site [polypeptide binding]; other site 265669004588 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 265669004589 Zn binding sites [ion binding]; other site 265669004590 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 265669004591 dimer interface [polypeptide binding]; other site 265669004592 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 265669004593 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 265669004594 nucleotide binding site [chemical binding]; other site 265669004595 NEF interaction site [polypeptide binding]; other site 265669004596 SBD interface [polypeptide binding]; other site 265669004597 heat shock protein GrpE; Provisional; Region: PRK14140 265669004598 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 265669004599 dimer interface [polypeptide binding]; other site 265669004600 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 265669004601 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 265669004602 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 265669004603 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 265669004604 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 265669004605 FeS/SAM binding site; other site 265669004606 HemN C-terminal domain; Region: HemN_C; pfam06969 265669004607 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 265669004608 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 265669004609 NADP binding site [chemical binding]; other site 265669004610 putative substrate binding site [chemical binding]; other site 265669004611 active site 265669004612 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 265669004613 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 265669004614 DNA binding residues [nucleotide binding] 265669004615 putative dimer interface [polypeptide binding]; other site 265669004616 GTP-binding protein LepA; Provisional; Region: PRK05433 265669004617 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 265669004618 G1 box; other site 265669004619 putative GEF interaction site [polypeptide binding]; other site 265669004620 GTP/Mg2+ binding site [chemical binding]; other site 265669004621 Switch I region; other site 265669004622 G2 box; other site 265669004623 G3 box; other site 265669004624 Switch II region; other site 265669004625 G4 box; other site 265669004626 G5 box; other site 265669004627 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 265669004628 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 265669004629 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 265669004630 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 265669004631 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 265669004632 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 265669004633 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 265669004634 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 265669004635 Competence protein; Region: Competence; pfam03772 265669004636 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 265669004637 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 265669004638 catalytic motif [active] 265669004639 Zn binding site [ion binding]; other site 265669004640 SLBB domain; Region: SLBB; pfam10531 265669004641 comEA protein; Region: comE; TIGR01259 265669004642 Helix-hairpin-helix motif; Region: HHH; pfam00633 265669004643 Methyltransferase domain; Region: Methyltransf_23; pfam13489 265669004644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669004645 S-adenosylmethionine binding site [chemical binding]; other site 265669004646 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 265669004647 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 265669004648 Zn2+ binding site [ion binding]; other site 265669004649 Mg2+ binding site [ion binding]; other site 265669004650 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 265669004651 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 265669004652 active site 265669004653 (T/H)XGH motif; other site 265669004654 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 265669004655 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 265669004656 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 265669004657 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 265669004658 shikimate binding site; other site 265669004659 NAD(P) binding site [chemical binding]; other site 265669004660 GTPase YqeH; Provisional; Region: PRK13796 265669004661 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 265669004662 GTP/Mg2+ binding site [chemical binding]; other site 265669004663 G4 box; other site 265669004664 G5 box; other site 265669004665 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 265669004666 G1 box; other site 265669004667 G1 box; other site 265669004668 GTP/Mg2+ binding site [chemical binding]; other site 265669004669 G2 box; other site 265669004670 Switch I region; other site 265669004671 G2 box; other site 265669004672 Switch I region; other site 265669004673 G3 box; other site 265669004674 G3 box; other site 265669004675 Switch II region; other site 265669004676 Switch II region; other site 265669004677 G4 box; other site 265669004678 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 265669004679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669004680 motif II; other site 265669004681 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 265669004682 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 265669004683 active site 265669004684 Zn binding site [ion binding]; other site 265669004685 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 265669004686 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 265669004687 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 265669004688 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 265669004689 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 265669004690 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 265669004691 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 265669004692 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 265669004693 Sugar specificity; other site 265669004694 Pyrimidine base specificity; other site 265669004695 ATP-binding site [chemical binding]; other site 265669004696 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 265669004697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669004698 S-adenosylmethionine binding site [chemical binding]; other site 265669004699 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 265669004700 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 265669004701 dimerization interface [polypeptide binding]; other site 265669004702 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 265669004703 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 265669004704 hypothetical protein; Provisional; Region: PRK13678 265669004705 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 265669004706 hypothetical protein; Provisional; Region: PRK05473 265669004707 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 265669004708 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 265669004709 motif 1; other site 265669004710 active site 265669004711 motif 2; other site 265669004712 motif 3; other site 265669004713 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 265669004714 DHHA1 domain; Region: DHHA1; pfam02272 265669004715 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 265669004716 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 265669004717 Walker A/P-loop; other site 265669004718 ATP binding site [chemical binding]; other site 265669004719 Q-loop/lid; other site 265669004720 ABC transporter signature motif; other site 265669004721 Walker B; other site 265669004722 D-loop; other site 265669004723 H-loop/switch region; other site 265669004724 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 265669004725 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 265669004726 FtsX-like permease family; Region: FtsX; pfam02687 265669004727 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 265669004728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669004729 active site 265669004730 phosphorylation site [posttranslational modification] 265669004731 intermolecular recognition site; other site 265669004732 dimerization interface [polypeptide binding]; other site 265669004733 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 265669004734 DNA binding site [nucleotide binding] 265669004735 sensor kinase CusS; Provisional; Region: PRK09835 265669004736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 265669004737 dimerization interface [polypeptide binding]; other site 265669004738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 265669004739 dimer interface [polypeptide binding]; other site 265669004740 phosphorylation site [posttranslational modification] 265669004741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669004742 ATP binding site [chemical binding]; other site 265669004743 Mg2+ binding site [ion binding]; other site 265669004744 G-X-G motif; other site 265669004745 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 265669004746 AAA domain; Region: AAA_30; pfam13604 265669004747 Family description; Region: UvrD_C_2; pfam13538 265669004748 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 265669004749 binding surface 265669004750 TPR motif; other site 265669004751 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 265669004752 TPR repeat; Region: TPR_11; pfam13414 265669004753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 265669004754 binding surface 265669004755 TPR motif; other site 265669004756 TPR repeat; Region: TPR_11; pfam13414 265669004757 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 265669004758 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 265669004759 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 265669004760 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 265669004761 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 265669004762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 265669004763 catalytic residue [active] 265669004764 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 265669004765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669004766 Walker A motif; other site 265669004767 ATP binding site [chemical binding]; other site 265669004768 Walker B motif; other site 265669004769 arginine finger; other site 265669004770 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 265669004771 Predicted transcriptional regulator [Transcription]; Region: COG1959 265669004772 Transcriptional regulator; Region: Rrf2; pfam02082 265669004773 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 265669004774 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 265669004775 Nitrogen regulatory protein P-II; Region: P-II; smart00938 265669004776 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 265669004777 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 265669004778 dimer interface [polypeptide binding]; other site 265669004779 anticodon binding site; other site 265669004780 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 265669004781 homodimer interface [polypeptide binding]; other site 265669004782 motif 1; other site 265669004783 active site 265669004784 motif 2; other site 265669004785 GAD domain; Region: GAD; pfam02938 265669004786 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 265669004787 motif 3; other site 265669004788 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 265669004789 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 265669004790 dimer interface [polypeptide binding]; other site 265669004791 motif 1; other site 265669004792 active site 265669004793 motif 2; other site 265669004794 motif 3; other site 265669004795 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 265669004796 anticodon binding site; other site 265669004797 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 265669004798 Bacterial SH3 domain; Region: SH3_3; pfam08239 265669004799 Bacterial SH3 domain; Region: SH3_3; pfam08239 265669004800 Bacterial SH3 domain homologues; Region: SH3b; smart00287 265669004801 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 265669004802 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 265669004803 active site 265669004804 metal binding site [ion binding]; metal-binding site 265669004805 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 265669004806 putative active site [active] 265669004807 dimerization interface [polypeptide binding]; other site 265669004808 putative tRNAtyr binding site [nucleotide binding]; other site 265669004809 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 265669004810 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 265669004811 Zn2+ binding site [ion binding]; other site 265669004812 Mg2+ binding site [ion binding]; other site 265669004813 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 265669004814 synthetase active site [active] 265669004815 NTP binding site [chemical binding]; other site 265669004816 metal binding site [ion binding]; metal-binding site 265669004817 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 265669004818 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 265669004819 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 265669004820 active site 265669004821 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 265669004822 DHH family; Region: DHH; pfam01368 265669004823 DHHA1 domain; Region: DHHA1; pfam02272 265669004824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 265669004825 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 265669004826 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 265669004827 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 265669004828 Protein export membrane protein; Region: SecD_SecF; cl14618 265669004829 Protein export membrane protein; Region: SecD_SecF; pfam02355 265669004830 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 265669004831 Preprotein translocase subunit; Region: YajC; pfam02699 265669004832 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 265669004833 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 265669004834 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 265669004835 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 265669004836 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 265669004837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669004838 Walker A motif; other site 265669004839 ATP binding site [chemical binding]; other site 265669004840 Walker B motif; other site 265669004841 arginine finger; other site 265669004842 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 265669004843 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 265669004844 RuvA N terminal domain; Region: RuvA_N; pfam01330 265669004845 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 265669004846 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 265669004847 tetramer (dimer of dimers) interface [polypeptide binding]; other site 265669004848 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 265669004849 NAD binding site [chemical binding]; other site 265669004850 dimer interface [polypeptide binding]; other site 265669004851 substrate binding site [chemical binding]; other site 265669004852 hypothetical protein; Validated; Region: PRK00110 265669004853 prephenate dehydratase; Provisional; Region: PRK11898 265669004854 Prephenate dehydratase; Region: PDT; pfam00800 265669004855 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 265669004856 putative L-Phe binding site [chemical binding]; other site 265669004857 GTPase CgtA; Reviewed; Region: obgE; PRK12297 265669004858 GTP1/OBG; Region: GTP1_OBG; pfam01018 265669004859 Obg GTPase; Region: Obg; cd01898 265669004860 G1 box; other site 265669004861 GTP/Mg2+ binding site [chemical binding]; other site 265669004862 Switch I region; other site 265669004863 G2 box; other site 265669004864 G3 box; other site 265669004865 Switch II region; other site 265669004866 G4 box; other site 265669004867 G5 box; other site 265669004868 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 265669004869 glycerol kinase; Provisional; Region: glpK; PRK00047 265669004870 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 265669004871 N- and C-terminal domain interface [polypeptide binding]; other site 265669004872 active site 265669004873 MgATP binding site [chemical binding]; other site 265669004874 catalytic site [active] 265669004875 metal binding site [ion binding]; metal-binding site 265669004876 glycerol binding site [chemical binding]; other site 265669004877 homotetramer interface [polypeptide binding]; other site 265669004878 homodimer interface [polypeptide binding]; other site 265669004879 FBP binding site [chemical binding]; other site 265669004880 protein IIAGlc interface [polypeptide binding]; other site 265669004881 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 265669004882 amphipathic channel; other site 265669004883 Asn-Pro-Ala signature motifs; other site 265669004884 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 265669004885 hypothetical protein; Provisional; Region: PRK14553 265669004886 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 265669004887 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 265669004888 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 265669004889 homodimer interface [polypeptide binding]; other site 265669004890 oligonucleotide binding site [chemical binding]; other site 265669004891 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 265669004892 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 265669004893 Switch I; other site 265669004894 Switch II; other site 265669004895 septum formation inhibitor; Reviewed; Region: minC; PRK00513 265669004896 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 265669004897 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 265669004898 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 265669004899 Protein of unknown function (DUF972); Region: DUF972; pfam06156 265669004900 rod shape-determining protein MreC; Region: MreC; pfam04085 265669004901 rod shape-determining protein MreB; Provisional; Region: PRK13927 265669004902 MreB and similar proteins; Region: MreB_like; cd10225 265669004903 nucleotide binding site [chemical binding]; other site 265669004904 Mg binding site [ion binding]; other site 265669004905 putative protofilament interaction site [polypeptide binding]; other site 265669004906 RodZ interaction site [polypeptide binding]; other site 265669004907 hypothetical protein; Reviewed; Region: PRK00024 265669004908 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 265669004909 MPN+ (JAMM) motif; other site 265669004910 Zinc-binding site [ion binding]; other site 265669004911 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 265669004912 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 265669004913 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 265669004914 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 265669004915 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 265669004916 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 265669004917 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 265669004918 active site 265669004919 HIGH motif; other site 265669004920 nucleotide binding site [chemical binding]; other site 265669004921 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 265669004922 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 265669004923 active site 265669004924 KMSKS motif; other site 265669004925 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 265669004926 tRNA binding surface [nucleotide binding]; other site 265669004927 anticodon binding site; other site 265669004928 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 265669004929 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 265669004930 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 265669004931 inhibitor-cofactor binding pocket; inhibition site 265669004932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669004933 catalytic residue [active] 265669004934 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 265669004935 dimer interface [polypeptide binding]; other site 265669004936 active site 265669004937 Schiff base residues; other site 265669004938 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 265669004939 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 265669004940 active site 265669004941 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 265669004942 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 265669004943 domain interfaces; other site 265669004944 active site 265669004945 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 265669004946 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 265669004947 tRNA; other site 265669004948 putative tRNA binding site [nucleotide binding]; other site 265669004949 putative NADP binding site [chemical binding]; other site 265669004950 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 265669004951 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 265669004952 G1 box; other site 265669004953 GTP/Mg2+ binding site [chemical binding]; other site 265669004954 Switch I region; other site 265669004955 G2 box; other site 265669004956 G3 box; other site 265669004957 Switch II region; other site 265669004958 G4 box; other site 265669004959 G5 box; other site 265669004960 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 265669004961 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 265669004962 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 265669004963 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 265669004964 active site 265669004965 dimer interface [polypeptide binding]; other site 265669004966 motif 1; other site 265669004967 motif 2; other site 265669004968 motif 3; other site 265669004969 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 265669004970 anticodon binding site; other site 265669004971 primosomal protein DnaI; Reviewed; Region: PRK08939 265669004972 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 265669004973 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 265669004974 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 265669004975 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 265669004976 ATP cone domain; Region: ATP-cone; pfam03477 265669004977 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 265669004978 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 265669004979 CoA-binding site [chemical binding]; other site 265669004980 ATP-binding [chemical binding]; other site 265669004981 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 265669004982 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 265669004983 DNA binding site [nucleotide binding] 265669004984 catalytic residue [active] 265669004985 H2TH interface [polypeptide binding]; other site 265669004986 putative catalytic residues [active] 265669004987 turnover-facilitating residue; other site 265669004988 intercalation triad [nucleotide binding]; other site 265669004989 8OG recognition residue [nucleotide binding]; other site 265669004990 putative reading head residues; other site 265669004991 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 265669004992 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 265669004993 DNA polymerase I; Provisional; Region: PRK05755 265669004994 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 265669004995 active site 265669004996 metal binding site 1 [ion binding]; metal-binding site 265669004997 putative 5' ssDNA interaction site; other site 265669004998 metal binding site 3; metal-binding site 265669004999 metal binding site 2 [ion binding]; metal-binding site 265669005000 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 265669005001 putative DNA binding site [nucleotide binding]; other site 265669005002 putative metal binding site [ion binding]; other site 265669005003 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 265669005004 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 265669005005 active site 265669005006 DNA binding site [nucleotide binding] 265669005007 catalytic site [active] 265669005008 isocitrate dehydrogenase; Reviewed; Region: PRK07006 265669005009 isocitrate dehydrogenase; Validated; Region: PRK07362 265669005010 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 265669005011 dimer interface [polypeptide binding]; other site 265669005012 Citrate synthase; Region: Citrate_synt; pfam00285 265669005013 active site 265669005014 citrylCoA binding site [chemical binding]; other site 265669005015 oxalacetate/citrate binding site [chemical binding]; other site 265669005016 coenzyme A binding site [chemical binding]; other site 265669005017 catalytic triad [active] 265669005018 Protein of unknown function (DUF441); Region: DUF441; pfam04284 265669005019 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 265669005020 pyruvate kinase; Provisional; Region: PRK06354 265669005021 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 265669005022 domain interfaces; other site 265669005023 active site 265669005024 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 265669005025 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 265669005026 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 265669005027 active site 265669005028 ADP/pyrophosphate binding site [chemical binding]; other site 265669005029 dimerization interface [polypeptide binding]; other site 265669005030 allosteric effector site; other site 265669005031 fructose-1,6-bisphosphate binding site; other site 265669005032 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 265669005033 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 265669005034 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 265669005035 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 265669005036 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 265669005037 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 265669005038 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 265669005039 active site 265669005040 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 265669005041 generic binding surface I; other site 265669005042 generic binding surface II; other site 265669005043 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 265669005044 DHH family; Region: DHH; pfam01368 265669005045 DHHA1 domain; Region: DHHA1; pfam02272 265669005046 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 265669005047 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 265669005048 DNA-binding site [nucleotide binding]; DNA binding site 265669005049 DRTGG domain; Region: DRTGG; pfam07085 265669005050 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 265669005051 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 265669005052 active site 2 [active] 265669005053 active site 1 [active] 265669005054 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 265669005055 metal-dependent hydrolase; Provisional; Region: PRK00685 265669005056 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 265669005057 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 265669005058 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 265669005059 active site 265669005060 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 265669005061 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 265669005062 hexamer interface [polypeptide binding]; other site 265669005063 ligand binding site [chemical binding]; other site 265669005064 putative active site [active] 265669005065 NAD(P) binding site [chemical binding]; other site 265669005066 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 265669005067 Ligand Binding Site [chemical binding]; other site 265669005068 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 265669005069 propionate/acetate kinase; Provisional; Region: PRK12379 265669005070 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 265669005071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669005072 S-adenosylmethionine binding site [chemical binding]; other site 265669005073 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 265669005074 dimer interface [polypeptide binding]; other site 265669005075 catalytic triad [active] 265669005076 peroxidatic and resolving cysteines [active] 265669005077 RDD family; Region: RDD; pfam06271 265669005078 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 265669005079 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 265669005080 tandem repeat interface [polypeptide binding]; other site 265669005081 oligomer interface [polypeptide binding]; other site 265669005082 active site residues [active] 265669005083 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 265669005084 ATP-NAD kinase; Region: NAD_kinase; pfam01513 265669005085 ornithine carbamoyltransferase; Provisional; Region: PRK00779 265669005086 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 265669005087 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 265669005088 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 265669005089 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 265669005090 inhibitor-cofactor binding pocket; inhibition site 265669005091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669005092 catalytic residue [active] 265669005093 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 265669005094 nucleotide binding site [chemical binding]; other site 265669005095 N-acetyl-L-glutamate binding site [chemical binding]; other site 265669005096 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 265669005097 heterotetramer interface [polypeptide binding]; other site 265669005098 active site pocket [active] 265669005099 cleavage site 265669005100 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 265669005101 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 265669005102 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 265669005103 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 265669005104 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 265669005105 Ligand Binding Site [chemical binding]; other site 265669005106 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 265669005107 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 265669005108 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 265669005109 catalytic residue [active] 265669005110 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 265669005111 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 265669005112 GAF domain; Region: GAF_2; pfam13185 265669005113 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 265669005114 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 265669005115 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 265669005116 RNA binding surface [nucleotide binding]; other site 265669005117 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 265669005118 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 265669005119 active site 265669005120 HIGH motif; other site 265669005121 dimer interface [polypeptide binding]; other site 265669005122 KMSKS motif; other site 265669005123 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 265669005124 RNA binding surface [nucleotide binding]; other site 265669005125 catabolite control protein A; Region: ccpA; TIGR01481 265669005126 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 265669005127 DNA binding site [nucleotide binding] 265669005128 domain linker motif; other site 265669005129 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 265669005130 dimerization interface [polypeptide binding]; other site 265669005131 effector binding site; other site 265669005132 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 265669005133 Chorismate mutase type II; Region: CM_2; cl00693 265669005134 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 265669005135 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 265669005136 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 265669005137 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 265669005138 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 265669005139 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 265669005140 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 265669005141 dimer interface [polypeptide binding]; other site 265669005142 decamer (pentamer of dimers) interface [polypeptide binding]; other site 265669005143 catalytic triad [active] 265669005144 peroxidatic and resolving cysteines [active] 265669005145 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 265669005146 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 265669005147 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 265669005148 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 265669005149 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 265669005150 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 265669005151 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 265669005152 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 265669005153 putative tRNA-binding site [nucleotide binding]; other site 265669005154 hypothetical protein; Provisional; Region: PRK13668 265669005155 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 265669005156 catalytic residues [active] 265669005157 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 265669005158 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 265669005159 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 265669005160 oligomer interface [polypeptide binding]; other site 265669005161 active site 265669005162 metal binding site [ion binding]; metal-binding site 265669005163 Predicted small secreted protein [Function unknown]; Region: COG5584 265669005164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 265669005165 putative homodimer interface [polypeptide binding]; other site 265669005166 putative homotetramer interface [polypeptide binding]; other site 265669005167 putative allosteric switch controlling residues; other site 265669005168 putative metal binding site [ion binding]; other site 265669005169 putative homodimer-homodimer interface [polypeptide binding]; other site 265669005170 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 265669005171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669005172 S-adenosylmethionine binding site [chemical binding]; other site 265669005173 Phosphotransferase enzyme family; Region: APH; pfam01636 265669005174 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 265669005175 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 265669005176 MarR family; Region: MarR; pfam01047 265669005177 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 265669005178 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 265669005179 homodimer interface [polypeptide binding]; other site 265669005180 substrate-cofactor binding pocket; other site 265669005181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669005182 catalytic residue [active] 265669005183 dipeptidase PepV; Reviewed; Region: PRK07318 265669005184 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 265669005185 active site 265669005186 metal binding site [ion binding]; metal-binding site 265669005187 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 265669005188 nudix motif; other site 265669005189 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 265669005190 putative substrate binding site [chemical binding]; other site 265669005191 putative ATP binding site [chemical binding]; other site 265669005192 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 265669005193 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 265669005194 active site 265669005195 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 265669005196 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 265669005197 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 265669005198 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 265669005199 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 265669005200 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 265669005201 substrate binding site [chemical binding]; other site 265669005202 active site 265669005203 catalytic residues [active] 265669005204 heterodimer interface [polypeptide binding]; other site 265669005205 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 265669005206 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 265669005207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669005208 catalytic residue [active] 265669005209 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 265669005210 active site 265669005211 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 265669005212 active site 265669005213 ribulose/triose binding site [chemical binding]; other site 265669005214 phosphate binding site [ion binding]; other site 265669005215 substrate (anthranilate) binding pocket [chemical binding]; other site 265669005216 product (indole) binding pocket [chemical binding]; other site 265669005217 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 265669005218 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 265669005219 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 265669005220 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 265669005221 Glutamine amidotransferase class-I; Region: GATase; pfam00117 265669005222 glutamine binding [chemical binding]; other site 265669005223 catalytic triad [active] 265669005224 anthranilate synthase component I; Provisional; Region: PRK13570 265669005225 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 265669005226 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 265669005227 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 265669005228 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 265669005229 putative catalytic cysteine [active] 265669005230 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 265669005231 putative active site [active] 265669005232 metal binding site [ion binding]; metal-binding site 265669005233 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 265669005234 dimer interface [polypeptide binding]; other site 265669005235 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 265669005236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669005237 Walker A/P-loop; other site 265669005238 ATP binding site [chemical binding]; other site 265669005239 Q-loop/lid; other site 265669005240 ABC transporter signature motif; other site 265669005241 Walker B; other site 265669005242 D-loop; other site 265669005243 H-loop/switch region; other site 265669005244 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 265669005245 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 265669005246 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 265669005247 putative dimer interface [polypeptide binding]; other site 265669005248 catalytic triad [active] 265669005249 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 265669005250 aconitate hydratase; Validated; Region: PRK09277 265669005251 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 265669005252 substrate binding site [chemical binding]; other site 265669005253 ligand binding site [chemical binding]; other site 265669005254 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 265669005255 substrate binding site [chemical binding]; other site 265669005256 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 265669005257 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 265669005258 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 265669005259 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 265669005260 ATP binding site [chemical binding]; other site 265669005261 putative Mg++ binding site [ion binding]; other site 265669005262 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 265669005263 nucleotide binding region [chemical binding]; other site 265669005264 ATP-binding site [chemical binding]; other site 265669005265 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 265669005266 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 265669005267 Walker A/P-loop; other site 265669005268 ATP binding site [chemical binding]; other site 265669005269 Q-loop/lid; other site 265669005270 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 265669005271 ABC transporter signature motif; other site 265669005272 Walker B; other site 265669005273 D-loop; other site 265669005274 H-loop/switch region; other site 265669005275 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 265669005276 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 265669005277 active site 265669005278 metal binding site [ion binding]; metal-binding site 265669005279 DNA binding site [nucleotide binding] 265669005280 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 265669005281 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 265669005282 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 265669005283 putative acyl-acceptor binding pocket; other site 265669005284 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 265669005285 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 265669005286 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 265669005287 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 265669005288 Walker A/P-loop; other site 265669005289 ATP binding site [chemical binding]; other site 265669005290 Q-loop/lid; other site 265669005291 ABC transporter signature motif; other site 265669005292 Walker B; other site 265669005293 D-loop; other site 265669005294 H-loop/switch region; other site 265669005295 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 265669005296 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 265669005297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669005298 Walker A/P-loop; other site 265669005299 ATP binding site [chemical binding]; other site 265669005300 Q-loop/lid; other site 265669005301 ABC transporter signature motif; other site 265669005302 Walker B; other site 265669005303 D-loop; other site 265669005304 H-loop/switch region; other site 265669005305 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 265669005306 active site 265669005307 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 265669005308 elongation factor Ts; Provisional; Region: tsf; PRK09377 265669005309 UBA/TS-N domain; Region: UBA; pfam00627 265669005310 Elongation factor TS; Region: EF_TS; pfam00889 265669005311 Elongation factor TS; Region: EF_TS; pfam00889 265669005312 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 265669005313 rRNA interaction site [nucleotide binding]; other site 265669005314 S8 interaction site; other site 265669005315 putative laminin-1 binding site; other site 265669005316 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 265669005317 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 265669005318 active site turn [active] 265669005319 phosphorylation site [posttranslational modification] 265669005320 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 265669005321 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 265669005322 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 265669005323 putative active site [active] 265669005324 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 265669005325 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 265669005326 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 265669005327 putative active site [active] 265669005328 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 265669005329 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 265669005330 HIGH motif; other site 265669005331 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 265669005332 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 265669005333 active site 265669005334 KMSKS motif; other site 265669005335 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 265669005336 tRNA binding surface [nucleotide binding]; other site 265669005337 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 265669005338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 265669005339 FeS/SAM binding site; other site 265669005340 Methyltransferase domain; Region: Methyltransf_31; pfam13847 265669005341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669005342 S-adenosylmethionine binding site [chemical binding]; other site 265669005343 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 265669005344 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 265669005345 active site 265669005346 dimer interface [polypeptide binding]; other site 265669005347 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 265669005348 Ligand Binding Site [chemical binding]; other site 265669005349 Molecular Tunnel; other site 265669005350 S-adenosylmethionine synthetase; Validated; Region: PRK05250 265669005351 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 265669005352 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 265669005353 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 265669005354 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 265669005355 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 265669005356 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 265669005357 tetramer (dimer of dimers) interface [polypeptide binding]; other site 265669005358 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 265669005359 NAD binding site [chemical binding]; other site 265669005360 dimer interface [polypeptide binding]; other site 265669005361 substrate binding site [chemical binding]; other site 265669005362 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 265669005363 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 265669005364 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 265669005365 nudix motif; other site 265669005366 Uncharacterized conserved protein [Function unknown]; Region: COG0759 265669005367 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 265669005368 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 265669005369 metal binding site [ion binding]; metal-binding site 265669005370 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 265669005371 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 265669005372 acyl-activating enzyme (AAE) consensus motif; other site 265669005373 putative AMP binding site [chemical binding]; other site 265669005374 putative active site [active] 265669005375 putative CoA binding site [chemical binding]; other site 265669005376 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 265669005377 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 265669005378 substrate binding site [chemical binding]; other site 265669005379 oxyanion hole (OAH) forming residues; other site 265669005380 trimer interface [polypeptide binding]; other site 265669005381 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 265669005382 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 265669005383 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 265669005384 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 265669005385 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 265669005386 dimer interface [polypeptide binding]; other site 265669005387 tetramer interface [polypeptide binding]; other site 265669005388 PYR/PP interface [polypeptide binding]; other site 265669005389 TPP binding site [chemical binding]; other site 265669005390 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 265669005391 TPP-binding site; other site 265669005392 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 265669005393 chorismate binding enzyme; Region: Chorismate_bind; cl10555 265669005394 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 265669005395 UbiA prenyltransferase family; Region: UbiA; pfam01040 265669005396 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 265669005397 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 265669005398 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 265669005399 FAD binding site [chemical binding]; other site 265669005400 cystathionine beta-lyase; Provisional; Region: PRK08064 265669005401 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 265669005402 homodimer interface [polypeptide binding]; other site 265669005403 substrate-cofactor binding pocket; other site 265669005404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669005405 catalytic residue [active] 265669005406 cystathionine gamma-synthase; Reviewed; Region: PRK08247 265669005407 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 265669005408 homodimer interface [polypeptide binding]; other site 265669005409 substrate-cofactor binding pocket; other site 265669005410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669005411 catalytic residue [active] 265669005412 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 265669005413 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 265669005414 THF binding site; other site 265669005415 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 265669005416 substrate binding site [chemical binding]; other site 265669005417 THF binding site; other site 265669005418 zinc-binding site [ion binding]; other site 265669005419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669005420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 265669005421 putative substrate translocation pore; other site 265669005422 ferric uptake regulator; Provisional; Region: fur; PRK09462 265669005423 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 265669005424 metal binding site 2 [ion binding]; metal-binding site 265669005425 putative DNA binding helix; other site 265669005426 metal binding site 1 [ion binding]; metal-binding site 265669005427 dimer interface [polypeptide binding]; other site 265669005428 structural Zn2+ binding site [ion binding]; other site 265669005429 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 265669005430 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 265669005431 NAD binding site [chemical binding]; other site 265669005432 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 265669005433 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 265669005434 inhibitor-cofactor binding pocket; inhibition site 265669005435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669005436 catalytic residue [active] 265669005437 Predicted membrane protein [Function unknown]; Region: COG4129 265669005438 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 265669005439 hypothetical protein; Provisional; Region: PRK13662 265669005440 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 265669005441 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 265669005442 putative NAD(P) binding site [chemical binding]; other site 265669005443 active site 265669005444 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 265669005445 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 265669005446 minor groove reading motif; other site 265669005447 helix-hairpin-helix signature motif; other site 265669005448 substrate binding pocket [chemical binding]; other site 265669005449 active site 265669005450 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 265669005451 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 265669005452 DNA binding and oxoG recognition site [nucleotide binding] 265669005453 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 265669005454 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 265669005455 trimer interface [polypeptide binding]; other site 265669005456 active site 265669005457 WVELL protein; Region: WVELL; pfam14043 265669005458 recombination regulator RecX; Provisional; Region: recX; PRK14135 265669005459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 265669005460 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 265669005461 NAD(P) binding site [chemical binding]; other site 265669005462 active site 265669005463 Predicted integral membrane protein [Function unknown]; Region: COG0392 265669005464 Uncharacterized conserved protein [Function unknown]; Region: COG2898 265669005465 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 265669005466 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 265669005467 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 265669005468 Cation efflux family; Region: Cation_efflux; pfam01545 265669005469 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 265669005470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 265669005471 PAS fold; Region: PAS_4; pfam08448 265669005472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 265669005473 putative active site [active] 265669005474 heme pocket [chemical binding]; other site 265669005475 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 265669005476 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 265669005477 dimer interface [polypeptide binding]; other site 265669005478 putative CheW interface [polypeptide binding]; other site 265669005479 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 265669005480 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 265669005481 dimer interface [polypeptide binding]; other site 265669005482 active site 265669005483 Mn binding site [ion binding]; other site 265669005484 TRAM domain; Region: TRAM; cl01282 265669005485 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 265669005486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669005487 S-adenosylmethionine binding site [chemical binding]; other site 265669005488 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 265669005489 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 265669005490 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 265669005491 Substrate-binding site [chemical binding]; other site 265669005492 Substrate specificity [chemical binding]; other site 265669005493 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 265669005494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 265669005495 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 265669005496 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 265669005497 active site 265669005498 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 265669005499 flavodoxin, short chain; Region: flav_short; TIGR01753 265669005500 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 265669005501 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 265669005502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669005503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 265669005504 putative substrate translocation pore; other site 265669005505 rod-share determining protein MreBH; Provisional; Region: PRK13929 265669005506 MreB and similar proteins; Region: MreB_like; cd10225 265669005507 nucleotide binding site [chemical binding]; other site 265669005508 Mg binding site [ion binding]; other site 265669005509 putative protofilament interaction site [polypeptide binding]; other site 265669005510 RodZ interaction site [polypeptide binding]; other site 265669005511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669005512 S-adenosylmethionine binding site [chemical binding]; other site 265669005513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 265669005514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 265669005515 Uncharacterized conserved protein [Function unknown]; Region: COG3589 265669005516 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 265669005517 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 265669005518 methionine cluster; other site 265669005519 active site 265669005520 phosphorylation site [posttranslational modification] 265669005521 metal binding site [ion binding]; metal-binding site 265669005522 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 265669005523 active site 265669005524 P-loop; other site 265669005525 phosphorylation site [posttranslational modification] 265669005526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 265669005527 DEAD-like helicases superfamily; Region: DEXDc; smart00487 265669005528 ATP binding site [chemical binding]; other site 265669005529 putative Mg++ binding site [ion binding]; other site 265669005530 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 265669005531 nucleotide binding region [chemical binding]; other site 265669005532 ATP-binding site [chemical binding]; other site 265669005533 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 265669005534 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 265669005535 Walker A/P-loop; other site 265669005536 ATP binding site [chemical binding]; other site 265669005537 Q-loop/lid; other site 265669005538 ABC transporter signature motif; other site 265669005539 Walker B; other site 265669005540 D-loop; other site 265669005541 H-loop/switch region; other site 265669005542 Predicted transcriptional regulators [Transcription]; Region: COG1725 265669005543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669005544 DNA-binding site [nucleotide binding]; DNA binding site 265669005545 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 265669005546 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 265669005547 Transcriptional regulators [Transcription]; Region: PurR; COG1609 265669005548 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 265669005549 DNA binding site [nucleotide binding] 265669005550 domain linker motif; other site 265669005551 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 265669005552 dimerization interface [polypeptide binding]; other site 265669005553 ligand binding site [chemical binding]; other site 265669005554 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 265669005555 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 265669005556 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 265669005557 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 265669005558 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 265669005559 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 265669005560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669005561 dimer interface [polypeptide binding]; other site 265669005562 conserved gate region; other site 265669005563 putative PBP binding loops; other site 265669005564 ABC-ATPase subunit interface; other site 265669005565 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 265669005566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669005567 dimer interface [polypeptide binding]; other site 265669005568 conserved gate region; other site 265669005569 putative PBP binding loops; other site 265669005570 ABC-ATPase subunit interface; other site 265669005571 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 265669005572 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 265669005573 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 265669005574 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 265669005575 active site 265669005576 dimer interface [polypeptide binding]; other site 265669005577 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 265669005578 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 265669005579 active site 265669005580 FMN binding site [chemical binding]; other site 265669005581 substrate binding site [chemical binding]; other site 265669005582 3Fe-4S cluster binding site [ion binding]; other site 265669005583 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 265669005584 domain interface; other site 265669005585 Transcriptional regulator [Transcription]; Region: LysR; COG0583 265669005586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 265669005587 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 265669005588 putative dimerization interface [polypeptide binding]; other site 265669005589 Predicted acetyltransferase [General function prediction only]; Region: COG3153 265669005590 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 265669005591 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 265669005592 putative active site [active] 265669005593 metal binding site [ion binding]; metal-binding site 265669005594 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 265669005595 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 265669005596 substrate binding pocket [chemical binding]; other site 265669005597 membrane-bound complex binding site; other site 265669005598 hinge residues; other site 265669005599 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 265669005600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669005601 Walker A/P-loop; other site 265669005602 ATP binding site [chemical binding]; other site 265669005603 Q-loop/lid; other site 265669005604 ABC transporter signature motif; other site 265669005605 Walker B; other site 265669005606 D-loop; other site 265669005607 H-loop/switch region; other site 265669005608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669005609 dimer interface [polypeptide binding]; other site 265669005610 conserved gate region; other site 265669005611 putative PBP binding loops; other site 265669005612 ABC-ATPase subunit interface; other site 265669005613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 265669005614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 265669005615 dimer interface [polypeptide binding]; other site 265669005616 phosphorylation site [posttranslational modification] 265669005617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669005618 ATP binding site [chemical binding]; other site 265669005619 Mg2+ binding site [ion binding]; other site 265669005620 G-X-G motif; other site 265669005621 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 265669005622 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 265669005623 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 265669005624 active site 265669005625 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 265669005626 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 265669005627 putative NAD(P) binding site [chemical binding]; other site 265669005628 active site 265669005629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 265669005630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669005631 active site 265669005632 phosphorylation site [posttranslational modification] 265669005633 intermolecular recognition site; other site 265669005634 dimerization interface [polypeptide binding]; other site 265669005635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 265669005636 DNA binding site [nucleotide binding] 265669005637 FtsX-like permease family; Region: FtsX; pfam02687 265669005638 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 265669005639 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 265669005640 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 265669005641 Walker A/P-loop; other site 265669005642 ATP binding site [chemical binding]; other site 265669005643 Q-loop/lid; other site 265669005644 ABC transporter signature motif; other site 265669005645 Walker B; other site 265669005646 D-loop; other site 265669005647 H-loop/switch region; other site 265669005648 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 265669005649 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 265669005650 ADP binding site [chemical binding]; other site 265669005651 magnesium binding site [ion binding]; other site 265669005652 putative shikimate binding site; other site 265669005653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 265669005654 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 265669005655 TRAM domain; Region: TRAM; pfam01938 265669005656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669005657 S-adenosylmethionine binding site [chemical binding]; other site 265669005658 putative lipid kinase; Reviewed; Region: PRK13337 265669005659 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 265669005660 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 265669005661 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 265669005662 GatB domain; Region: GatB_Yqey; smart00845 265669005663 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 265669005664 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 265669005665 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 265669005666 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 265669005667 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 265669005668 putative dimer interface [polypeptide binding]; other site 265669005669 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 265669005670 putative dimer interface [polypeptide binding]; other site 265669005671 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 265669005672 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 265669005673 nucleotide binding pocket [chemical binding]; other site 265669005674 K-X-D-G motif; other site 265669005675 catalytic site [active] 265669005676 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 265669005677 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 265669005678 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 265669005679 Dimer interface [polypeptide binding]; other site 265669005680 BRCT sequence motif; other site 265669005681 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 265669005682 Part of AAA domain; Region: AAA_19; pfam13245 265669005683 Family description; Region: UvrD_C_2; pfam13538 265669005684 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 265669005685 PcrB family; Region: PcrB; pfam01884 265669005686 substrate binding site [chemical binding]; other site 265669005687 putative active site [active] 265669005688 dimer interface [polypeptide binding]; other site 265669005689 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 265669005690 Na2 binding site [ion binding]; other site 265669005691 putative substrate binding site 1 [chemical binding]; other site 265669005692 Na binding site 1 [ion binding]; other site 265669005693 putative substrate binding site 2 [chemical binding]; other site 265669005694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 265669005695 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 265669005696 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 265669005697 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 265669005698 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 265669005699 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 265669005700 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 265669005701 purine monophosphate binding site [chemical binding]; other site 265669005702 dimer interface [polypeptide binding]; other site 265669005703 putative catalytic residues [active] 265669005704 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 265669005705 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 265669005706 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 265669005707 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 265669005708 active site 265669005709 substrate binding site [chemical binding]; other site 265669005710 cosubstrate binding site; other site 265669005711 catalytic site [active] 265669005712 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 265669005713 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 265669005714 dimerization interface [polypeptide binding]; other site 265669005715 putative ATP binding site [chemical binding]; other site 265669005716 amidophosphoribosyltransferase; Provisional; Region: PRK06781 265669005717 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 265669005718 active site 265669005719 tetramer interface [polypeptide binding]; other site 265669005720 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 265669005721 active site 265669005722 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 265669005723 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 265669005724 dimerization interface [polypeptide binding]; other site 265669005725 ATP binding site [chemical binding]; other site 265669005726 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 265669005727 dimerization interface [polypeptide binding]; other site 265669005728 ATP binding site [chemical binding]; other site 265669005729 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 265669005730 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 265669005731 putative active site [active] 265669005732 catalytic triad [active] 265669005733 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 265669005734 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 265669005735 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 265669005736 ATP binding site [chemical binding]; other site 265669005737 active site 265669005738 substrate binding site [chemical binding]; other site 265669005739 adenylosuccinate lyase; Provisional; Region: PRK07492 265669005740 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 265669005741 tetramer interface [polypeptide binding]; other site 265669005742 active site 265669005743 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 265669005744 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 265669005745 NAD binding site [chemical binding]; other site 265669005746 ATP-grasp domain; Region: ATP-grasp; pfam02222 265669005747 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 265669005748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 265669005749 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 265669005750 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 265669005751 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 265669005752 Zn2+ binding site [ion binding]; other site 265669005753 Mg2+ binding site [ion binding]; other site 265669005754 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 265669005755 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 265669005756 Walker A/P-loop; other site 265669005757 ATP binding site [chemical binding]; other site 265669005758 Q-loop/lid; other site 265669005759 ABC transporter signature motif; other site 265669005760 Walker B; other site 265669005761 D-loop; other site 265669005762 H-loop/switch region; other site 265669005763 peptidase T; Region: peptidase-T; TIGR01882 265669005764 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 265669005765 metal binding site [ion binding]; metal-binding site 265669005766 dimer interface [polypeptide binding]; other site 265669005767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 265669005768 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 265669005769 active site 265669005770 putative catalytic site [active] 265669005771 DNA binding site [nucleotide binding] 265669005772 putative phosphate binding site [ion binding]; other site 265669005773 metal binding site A [ion binding]; metal-binding site 265669005774 AP binding site [nucleotide binding]; other site 265669005775 metal binding site B [ion binding]; metal-binding site 265669005776 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 265669005777 23S rRNA binding site [nucleotide binding]; other site 265669005778 L21 binding site [polypeptide binding]; other site 265669005779 L13 binding site [polypeptide binding]; other site 265669005780 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 265669005781 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 265669005782 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 265669005783 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 265669005784 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 265669005785 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669005786 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 265669005787 Substrate binding site [chemical binding]; other site 265669005788 Leucine rich repeat; Region: LRR_8; pfam13855 265669005789 LRR adjacent; Region: LRR_adjacent; pfam08191 265669005790 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 265669005791 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 265669005792 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 265669005793 DNA binding residues [nucleotide binding] 265669005794 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 265669005795 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 265669005796 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 265669005797 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 265669005798 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 265669005799 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 265669005800 RimM N-terminal domain; Region: RimM; pfam01782 265669005801 PRC-barrel domain; Region: PRC; pfam05239 265669005802 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 265669005803 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 265669005804 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 265669005805 catalytic triad [active] 265669005806 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 265669005807 KH domain; Region: KH_4; pfam13083 265669005808 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 265669005809 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 265669005810 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 265669005811 signal recognition particle protein; Provisional; Region: PRK10867 265669005812 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 265669005813 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 265669005814 P loop; other site 265669005815 GTP binding site [chemical binding]; other site 265669005816 Signal peptide binding domain; Region: SRP_SPB; pfam02978 265669005817 putative DNA-binding protein; Validated; Region: PRK00118 265669005818 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 265669005819 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 265669005820 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 265669005821 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 265669005822 P loop; other site 265669005823 GTP binding site [chemical binding]; other site 265669005824 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 265669005825 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 265669005826 Walker A/P-loop; other site 265669005827 ATP binding site [chemical binding]; other site 265669005828 Q-loop/lid; other site 265669005829 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 265669005830 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 265669005831 linker region; other site 265669005832 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 265669005833 ABC transporter signature motif; other site 265669005834 Walker B; other site 265669005835 D-loop; other site 265669005836 H-loop/switch region; other site 265669005837 ribonuclease III; Reviewed; Region: rnc; PRK00102 265669005838 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 265669005839 dimerization interface [polypeptide binding]; other site 265669005840 active site 265669005841 metal binding site [ion binding]; metal-binding site 265669005842 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 265669005843 dsRNA binding site [nucleotide binding]; other site 265669005844 acyl carrier protein; Provisional; Region: acpP; PRK00982 265669005845 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 265669005846 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 265669005847 NAD(P) binding site [chemical binding]; other site 265669005848 homotetramer interface [polypeptide binding]; other site 265669005849 homodimer interface [polypeptide binding]; other site 265669005850 active site 265669005851 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 265669005852 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 265669005853 putative phosphate acyltransferase; Provisional; Region: PRK05331 265669005854 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 265669005855 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 265669005856 active site 2 [active] 265669005857 active site 1 [active] 265669005858 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 265669005859 Y-family of DNA polymerases; Region: PolY; cl12025 265669005860 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 265669005861 generic binding surface II; other site 265669005862 ssDNA binding site; other site 265669005863 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 265669005864 ATP binding site [chemical binding]; other site 265669005865 putative Mg++ binding site [ion binding]; other site 265669005866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 265669005867 nucleotide binding region [chemical binding]; other site 265669005868 ATP-binding site [chemical binding]; other site 265669005869 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 265669005870 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 265669005871 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 265669005872 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 265669005873 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 265669005874 putative L-serine binding site [chemical binding]; other site 265669005875 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 265669005876 DAK2 domain; Region: Dak2; pfam02734 265669005877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 265669005878 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 265669005879 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 265669005880 Thiamine pyrophosphokinase; Region: TPK; cd07995 265669005881 active site 265669005882 dimerization interface [polypeptide binding]; other site 265669005883 thiamine binding site [chemical binding]; other site 265669005884 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 265669005885 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 265669005886 substrate binding site [chemical binding]; other site 265669005887 hexamer interface [polypeptide binding]; other site 265669005888 metal binding site [ion binding]; metal-binding site 265669005889 GTPase RsgA; Reviewed; Region: PRK00098 265669005890 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 265669005891 RNA binding site [nucleotide binding]; other site 265669005892 homodimer interface [polypeptide binding]; other site 265669005893 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 265669005894 GTPase/Zn-binding domain interface [polypeptide binding]; other site 265669005895 GTP/Mg2+ binding site [chemical binding]; other site 265669005896 G4 box; other site 265669005897 G1 box; other site 265669005898 Switch I region; other site 265669005899 G2 box; other site 265669005900 G3 box; other site 265669005901 Switch II region; other site 265669005902 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 265669005903 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 265669005904 active site 265669005905 ATP binding site [chemical binding]; other site 265669005906 substrate binding site [chemical binding]; other site 265669005907 activation loop (A-loop); other site 265669005908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 265669005909 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 265669005910 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 265669005911 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 265669005912 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 265669005913 Protein phosphatase 2C; Region: PP2C; pfam00481 265669005914 active site 265669005915 16S rRNA methyltransferase B; Provisional; Region: PRK14902 265669005916 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 265669005917 putative RNA binding site [nucleotide binding]; other site 265669005918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669005919 S-adenosylmethionine binding site [chemical binding]; other site 265669005920 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 265669005921 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 265669005922 putative active site [active] 265669005923 substrate binding site [chemical binding]; other site 265669005924 putative cosubstrate binding site; other site 265669005925 catalytic site [active] 265669005926 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 265669005927 substrate binding site [chemical binding]; other site 265669005928 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 265669005929 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 265669005930 ATP binding site [chemical binding]; other site 265669005931 putative Mg++ binding site [ion binding]; other site 265669005932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 265669005933 ATP-binding site [chemical binding]; other site 265669005934 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 265669005935 Flavoprotein; Region: Flavoprotein; pfam02441 265669005936 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 265669005937 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 265669005938 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 265669005939 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 265669005940 catalytic site [active] 265669005941 G-X2-G-X-G-K; other site 265669005942 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 265669005943 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 265669005944 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 265669005945 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 265669005946 Domain of unknown function (DUF814); Region: DUF814; pfam05670 265669005947 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 265669005948 putative NAD(P) binding site [chemical binding]; other site 265669005949 homodimer interface [polypeptide binding]; other site 265669005950 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 265669005951 active site 265669005952 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 265669005953 active site 265669005954 dimer interface [polypeptide binding]; other site 265669005955 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 265669005956 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 265669005957 heterodimer interface [polypeptide binding]; other site 265669005958 active site 265669005959 FMN binding site [chemical binding]; other site 265669005960 homodimer interface [polypeptide binding]; other site 265669005961 substrate binding site [chemical binding]; other site 265669005962 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 265669005963 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 265669005964 FAD binding pocket [chemical binding]; other site 265669005965 FAD binding motif [chemical binding]; other site 265669005966 phosphate binding motif [ion binding]; other site 265669005967 beta-alpha-beta structure motif; other site 265669005968 NAD binding pocket [chemical binding]; other site 265669005969 Iron coordination center [ion binding]; other site 265669005970 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 265669005971 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 265669005972 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 265669005973 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 265669005974 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 265669005975 ATP-grasp domain; Region: ATP-grasp_4; cl17255 265669005976 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 265669005977 IMP binding site; other site 265669005978 dimer interface [polypeptide binding]; other site 265669005979 interdomain contacts; other site 265669005980 partial ornithine binding site; other site 265669005981 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 265669005982 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 265669005983 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 265669005984 catalytic site [active] 265669005985 subunit interface [polypeptide binding]; other site 265669005986 dihydroorotase; Validated; Region: pyrC; PRK09357 265669005987 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 265669005988 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 265669005989 active site 265669005990 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 265669005991 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 265669005992 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 265669005993 uracil transporter; Provisional; Region: PRK10720 265669005994 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 265669005995 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 265669005996 active site 265669005997 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 265669005998 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 265669005999 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 265669006000 RNA binding surface [nucleotide binding]; other site 265669006001 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 265669006002 active site 265669006003 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 265669006004 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 265669006005 Sulfate transporter family; Region: Sulfate_transp; pfam00916 265669006006 multidrug efflux protein; Reviewed; Region: PRK01766 265669006007 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 265669006008 cation binding site [ion binding]; other site 265669006009 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 265669006010 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 265669006011 metal binding site [ion binding]; metal-binding site 265669006012 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 265669006013 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 265669006014 ABC-ATPase subunit interface; other site 265669006015 dimer interface [polypeptide binding]; other site 265669006016 putative PBP binding regions; other site 265669006017 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 265669006018 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 265669006019 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 265669006020 MarR family; Region: MarR; pfam01047 265669006021 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 265669006022 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 265669006023 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 265669006024 protein binding site [polypeptide binding]; other site 265669006025 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 265669006026 Catalytic dyad [active] 265669006027 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 265669006028 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 265669006029 metal-binding site [ion binding] 265669006030 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 265669006031 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 265669006032 metal-binding site [ion binding] 265669006033 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 265669006034 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669006035 motif II; other site 265669006036 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 265669006037 putative homodimer interface [polypeptide binding]; other site 265669006038 putative homotetramer interface [polypeptide binding]; other site 265669006039 putative allosteric switch controlling residues; other site 265669006040 putative metal binding site [ion binding]; other site 265669006041 putative homodimer-homodimer interface [polypeptide binding]; other site 265669006042 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 265669006043 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 265669006044 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 265669006045 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 265669006046 hypothetical protein; Provisional; Region: PRK13672 265669006047 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 265669006048 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 265669006049 methionine sulfoxide reductase B; Provisional; Region: PRK00222 265669006050 SelR domain; Region: SelR; pfam01641 265669006051 methionine sulfoxide reductase A; Provisional; Region: PRK14054 265669006052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 265669006053 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 265669006054 active site 265669006055 catalytic triad [active] 265669006056 oxyanion hole [active] 265669006057 EDD domain protein, DegV family; Region: DegV; TIGR00762 265669006058 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 265669006059 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 265669006060 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 265669006061 HTH domain; Region: HTH_11; pfam08279 265669006062 FOG: CBS domain [General function prediction only]; Region: COG0517 265669006063 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 265669006064 PEP synthetase regulatory protein; Provisional; Region: PRK05339 265669006065 pyruvate phosphate dikinase; Provisional; Region: PRK09279 265669006066 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 265669006067 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 265669006068 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 265669006069 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 265669006070 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 265669006071 Predicted membrane protein [Function unknown]; Region: COG4129 265669006072 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 265669006073 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 265669006074 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 265669006075 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 265669006076 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 265669006077 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 265669006078 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 265669006079 Clostridial hydrophobic W; Region: ChW; pfam07538 265669006080 Clostridial hydrophobic W; Region: ChW; pfam07538 265669006081 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 265669006082 active site 265669006083 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 265669006084 substrate binding site [chemical binding]; other site 265669006085 metal binding site [ion binding]; metal-binding site 265669006086 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 265669006087 Methyltransferase domain; Region: Methyltransf_18; pfam12847 265669006088 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 265669006089 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 265669006090 folate binding site [chemical binding]; other site 265669006091 NADP+ binding site [chemical binding]; other site 265669006092 thymidylate synthase; Region: thym_sym; TIGR03284 265669006093 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 265669006094 dimerization interface [polypeptide binding]; other site 265669006095 active site 265669006096 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 265669006097 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 265669006098 Walker A/P-loop; other site 265669006099 ATP binding site [chemical binding]; other site 265669006100 Q-loop/lid; other site 265669006101 ABC transporter signature motif; other site 265669006102 Walker B; other site 265669006103 D-loop; other site 265669006104 H-loop/switch region; other site 265669006105 ABC transporter; Region: ABC_tran_2; pfam12848 265669006106 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 265669006107 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 265669006108 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 265669006109 Potassium binding sites [ion binding]; other site 265669006110 Cesium cation binding sites [ion binding]; other site 265669006111 manganese transport transcriptional regulator; Provisional; Region: PRK03902 265669006112 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 265669006113 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 265669006114 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 265669006115 DNA-binding site [nucleotide binding]; DNA binding site 265669006116 RNA-binding motif; other site 265669006117 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 265669006118 RNA/DNA hybrid binding site [nucleotide binding]; other site 265669006119 active site 265669006120 5'-3' exonuclease; Region: 53EXOc; smart00475 265669006121 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 265669006122 active site 265669006123 metal binding site 1 [ion binding]; metal-binding site 265669006124 putative 5' ssDNA interaction site; other site 265669006125 metal binding site 3; metal-binding site 265669006126 metal binding site 2 [ion binding]; metal-binding site 265669006127 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 265669006128 putative DNA binding site [nucleotide binding]; other site 265669006129 putative metal binding site [ion binding]; other site 265669006130 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 265669006131 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 265669006132 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 265669006133 putative active site [active] 265669006134 xanthine permease; Region: pbuX; TIGR03173 265669006135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 265669006136 active site 265669006137 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 265669006138 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 265669006139 active site 265669006140 Zn binding site [ion binding]; other site 265669006141 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 265669006142 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 265669006143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 265669006144 cell division protein GpsB; Provisional; Region: PRK14127 265669006145 DivIVA domain; Region: DivI1A_domain; TIGR03544 265669006146 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 265669006147 hypothetical protein; Provisional; Region: PRK13660 265669006148 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 265669006149 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 265669006150 Transglycosylase; Region: Transgly; pfam00912 265669006151 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 265669006152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 265669006153 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 265669006154 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 265669006155 minor groove reading motif; other site 265669006156 helix-hairpin-helix signature motif; other site 265669006157 substrate binding pocket [chemical binding]; other site 265669006158 active site 265669006159 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 265669006160 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 265669006161 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 265669006162 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 265669006163 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 265669006164 putative dimer interface [polypeptide binding]; other site 265669006165 putative anticodon binding site; other site 265669006166 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 265669006167 homodimer interface [polypeptide binding]; other site 265669006168 motif 1; other site 265669006169 motif 2; other site 265669006170 active site 265669006171 motif 3; other site 265669006172 aspartate aminotransferase; Provisional; Region: PRK05764 265669006173 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 265669006174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669006175 homodimer interface [polypeptide binding]; other site 265669006176 catalytic residue [active] 265669006177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 265669006178 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 265669006179 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 265669006180 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 265669006181 active site 265669006182 catalytic site [active] 265669006183 substrate binding site [chemical binding]; other site 265669006184 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 265669006185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 265669006186 putative Mg++ binding site [ion binding]; other site 265669006187 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 265669006188 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 265669006189 tetramerization interface [polypeptide binding]; other site 265669006190 active site 265669006191 pantoate--beta-alanine ligase; Region: panC; TIGR00018 265669006192 Pantoate-beta-alanine ligase; Region: PanC; cd00560 265669006193 active site 265669006194 ATP-binding site [chemical binding]; other site 265669006195 pantoate-binding site; other site 265669006196 HXXH motif; other site 265669006197 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 265669006198 active site 265669006199 oligomerization interface [polypeptide binding]; other site 265669006200 metal binding site [ion binding]; metal-binding site 265669006201 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 265669006202 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 265669006203 catalytic residues [active] 265669006204 Biotin operon repressor [Transcription]; Region: BirA; COG1654 265669006205 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 265669006206 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 265669006207 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 265669006208 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 265669006209 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 265669006210 active site 265669006211 NTP binding site [chemical binding]; other site 265669006212 metal binding triad [ion binding]; metal-binding site 265669006213 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 265669006214 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 265669006215 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 265669006216 active site 265669006217 dimer interfaces [polypeptide binding]; other site 265669006218 catalytic residues [active] 265669006219 dihydrodipicolinate reductase; Provisional; Region: PRK00048 265669006220 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 265669006221 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 265669006222 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 265669006223 homodimer interface [polypeptide binding]; other site 265669006224 metal binding site [ion binding]; metal-binding site 265669006225 Uncharacterized conserved protein [Function unknown]; Region: COG1284 265669006226 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 265669006227 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 265669006228 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 265669006229 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 265669006230 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 265669006231 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 265669006232 metal binding site [ion binding]; metal-binding site 265669006233 active site 265669006234 I-site; other site 265669006235 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 265669006236 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 265669006237 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 265669006238 metal binding site [ion binding]; metal-binding site 265669006239 active site 265669006240 I-site; other site 265669006241 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 265669006242 malate dehydrogenase; Provisional; Region: PRK13529 265669006243 Malic enzyme, N-terminal domain; Region: malic; pfam00390 265669006244 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 265669006245 NAD(P) binding pocket [chemical binding]; other site 265669006246 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 265669006247 Beta-lactamase; Region: Beta-lactamase; pfam00144 265669006248 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 265669006249 Pyruvate formate lyase 1; Region: PFL1; cd01678 265669006250 coenzyme A binding site [chemical binding]; other site 265669006251 active site 265669006252 catalytic residues [active] 265669006253 glycine loop; other site 265669006254 HI0933-like protein; Region: HI0933_like; pfam03486 265669006255 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 265669006256 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 265669006257 Predicted membrane protein [Function unknown]; Region: COG4347 265669006258 hypothetical protein; Provisional; Region: PRK03636 265669006259 UPF0302 domain; Region: UPF0302; pfam08864 265669006260 IDEAL domain; Region: IDEAL; pfam08858 265669006261 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 265669006262 binding surface 265669006263 TPR motif; other site 265669006264 TPR repeat; Region: TPR_11; pfam13414 265669006265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 265669006266 binding surface 265669006267 TPR motif; other site 265669006268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 265669006269 binding surface 265669006270 TPR motif; other site 265669006271 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 265669006272 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 265669006273 hinge; other site 265669006274 active site 265669006275 prephenate dehydrogenase; Validated; Region: PRK06545 265669006276 prephenate dehydrogenase; Validated; Region: PRK08507 265669006277 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 265669006278 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 265669006279 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 265669006280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669006281 homodimer interface [polypeptide binding]; other site 265669006282 catalytic residue [active] 265669006283 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 265669006284 homotrimer interaction site [polypeptide binding]; other site 265669006285 active site 265669006286 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 265669006287 active site 265669006288 dimer interface [polypeptide binding]; other site 265669006289 metal binding site [ion binding]; metal-binding site 265669006290 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 265669006291 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 265669006292 Tetramer interface [polypeptide binding]; other site 265669006293 active site 265669006294 FMN-binding site [chemical binding]; other site 265669006295 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 265669006296 active site 265669006297 multimer interface [polypeptide binding]; other site 265669006298 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 265669006299 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 265669006300 substrate binding pocket [chemical binding]; other site 265669006301 chain length determination region; other site 265669006302 substrate-Mg2+ binding site; other site 265669006303 catalytic residues [active] 265669006304 aspartate-rich region 1; other site 265669006305 active site lid residues [active] 265669006306 aspartate-rich region 2; other site 265669006307 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 265669006308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669006309 S-adenosylmethionine binding site [chemical binding]; other site 265669006310 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 265669006311 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 265669006312 homodecamer interface [polypeptide binding]; other site 265669006313 GTP cyclohydrolase I; Provisional; Region: PLN03044 265669006314 active site 265669006315 putative catalytic site residues [active] 265669006316 zinc binding site [ion binding]; other site 265669006317 GTP-CH-I/GFRP interaction surface; other site 265669006318 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 265669006319 IHF dimer interface [polypeptide binding]; other site 265669006320 IHF - DNA interface [nucleotide binding]; other site 265669006321 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 265669006322 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 265669006323 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 265669006324 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 265669006325 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 265669006326 GTP-binding protein Der; Reviewed; Region: PRK00093 265669006327 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 265669006328 G1 box; other site 265669006329 GTP/Mg2+ binding site [chemical binding]; other site 265669006330 Switch I region; other site 265669006331 G2 box; other site 265669006332 Switch II region; other site 265669006333 G3 box; other site 265669006334 G4 box; other site 265669006335 G5 box; other site 265669006336 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 265669006337 G1 box; other site 265669006338 GTP/Mg2+ binding site [chemical binding]; other site 265669006339 Switch I region; other site 265669006340 G2 box; other site 265669006341 G3 box; other site 265669006342 Switch II region; other site 265669006343 G4 box; other site 265669006344 G5 box; other site 265669006345 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 265669006346 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 265669006347 RNA binding site [nucleotide binding]; other site 265669006348 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 265669006349 RNA binding site [nucleotide binding]; other site 265669006350 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 265669006351 RNA binding site [nucleotide binding]; other site 265669006352 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 265669006353 RNA binding site [nucleotide binding]; other site 265669006354 cytidylate kinase; Provisional; Region: cmk; PRK00023 265669006355 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 265669006356 CMP-binding site; other site 265669006357 The sites determining sugar specificity; other site 265669006358 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 265669006359 active site 265669006360 homotetramer interface [polypeptide binding]; other site 265669006361 homodimer interface [polypeptide binding]; other site 265669006362 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 265669006363 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 265669006364 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 265669006365 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 265669006366 ATP binding site [chemical binding]; other site 265669006367 putative Mg++ binding site [ion binding]; other site 265669006368 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 265669006369 nucleotide binding region [chemical binding]; other site 265669006370 ATP-binding site [chemical binding]; other site 265669006371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 265669006372 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 265669006373 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669006374 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669006375 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669006376 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669006377 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669006378 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669006379 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 265669006380 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669006381 Predicted membrane protein [Function unknown]; Region: COG3601 265669006382 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 265669006383 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 265669006384 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 265669006385 dimerization interface [polypeptide binding]; other site 265669006386 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 265669006387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 265669006388 dimer interface [polypeptide binding]; other site 265669006389 phosphorylation site [posttranslational modification] 265669006390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669006391 ATP binding site [chemical binding]; other site 265669006392 Mg2+ binding site [ion binding]; other site 265669006393 G-X-G motif; other site 265669006394 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 265669006395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669006396 active site 265669006397 phosphorylation site [posttranslational modification] 265669006398 intermolecular recognition site; other site 265669006399 dimerization interface [polypeptide binding]; other site 265669006400 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 265669006401 DNA binding site [nucleotide binding] 265669006402 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 265669006403 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 265669006404 RNA binding surface [nucleotide binding]; other site 265669006405 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 265669006406 active site 265669006407 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 265669006408 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 265669006409 diaminopimelate decarboxylase; Region: lysA; TIGR01048 265669006410 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 265669006411 active site 265669006412 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 265669006413 substrate binding site [chemical binding]; other site 265669006414 catalytic residues [active] 265669006415 dimer interface [polypeptide binding]; other site 265669006416 purine nucleoside phosphorylase; Provisional; Region: PRK08202 265669006417 phosphopentomutase; Provisional; Region: PRK05362 265669006418 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 265669006419 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 265669006420 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 265669006421 active site 265669006422 Int/Topo IB signature motif; other site 265669006423 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 265669006424 metal binding site 2 [ion binding]; metal-binding site 265669006425 putative DNA binding helix; other site 265669006426 metal binding site 1 [ion binding]; metal-binding site 265669006427 dimer interface [polypeptide binding]; other site 265669006428 structural Zn2+ binding site [ion binding]; other site 265669006429 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 265669006430 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 265669006431 ABC-ATPase subunit interface; other site 265669006432 dimer interface [polypeptide binding]; other site 265669006433 putative PBP binding regions; other site 265669006434 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 265669006435 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 265669006436 ABC-ATPase subunit interface; other site 265669006437 dimer interface [polypeptide binding]; other site 265669006438 putative PBP binding regions; other site 265669006439 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 265669006440 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 265669006441 putative ligand binding residues [chemical binding]; other site 265669006442 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 265669006443 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 265669006444 Walker A/P-loop; other site 265669006445 ATP binding site [chemical binding]; other site 265669006446 Q-loop/lid; other site 265669006447 ABC transporter signature motif; other site 265669006448 Walker B; other site 265669006449 D-loop; other site 265669006450 H-loop/switch region; other site 265669006451 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 265669006452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 265669006453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 265669006454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 265669006455 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 265669006456 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 265669006457 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 265669006458 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 265669006459 Walker A/P-loop; other site 265669006460 ATP binding site [chemical binding]; other site 265669006461 Q-loop/lid; other site 265669006462 ABC transporter signature motif; other site 265669006463 Walker B; other site 265669006464 D-loop; other site 265669006465 H-loop/switch region; other site 265669006466 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 265669006467 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 265669006468 dimer interface [polypeptide binding]; other site 265669006469 ADP-ribose binding site [chemical binding]; other site 265669006470 active site 265669006471 nudix motif; other site 265669006472 metal binding site [ion binding]; metal-binding site 265669006473 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 265669006474 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 265669006475 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 265669006476 active site 265669006477 DNA polymerase IV; Validated; Region: PRK02406 265669006478 DNA binding site [nucleotide binding] 265669006479 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 265669006480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 265669006481 NAD(P) binding site [chemical binding]; other site 265669006482 active site 265669006483 ribonuclease Z; Region: RNase_Z; TIGR02651 265669006484 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 265669006485 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 265669006486 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 265669006487 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 265669006488 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 265669006489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669006490 Coenzyme A binding pocket [chemical binding]; other site 265669006491 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 265669006492 6-phosphogluconate dehydratase; Region: edd; TIGR01196 265669006493 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 265669006494 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 265669006495 PYR/PP interface [polypeptide binding]; other site 265669006496 dimer interface [polypeptide binding]; other site 265669006497 TPP binding site [chemical binding]; other site 265669006498 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 265669006499 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 265669006500 TPP-binding site [chemical binding]; other site 265669006501 dimer interface [polypeptide binding]; other site 265669006502 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 265669006503 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 265669006504 putative valine binding site [chemical binding]; other site 265669006505 dimer interface [polypeptide binding]; other site 265669006506 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 265669006507 ketol-acid reductoisomerase; Provisional; Region: PRK05479 265669006508 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 265669006509 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 265669006510 2-isopropylmalate synthase; Validated; Region: PRK00915 265669006511 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 265669006512 active site 265669006513 catalytic residues [active] 265669006514 metal binding site [ion binding]; metal-binding site 265669006515 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 265669006516 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 265669006517 tartrate dehydrogenase; Region: TTC; TIGR02089 265669006518 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 265669006519 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 265669006520 substrate binding site [chemical binding]; other site 265669006521 ligand binding site [chemical binding]; other site 265669006522 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 265669006523 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 265669006524 substrate binding site [chemical binding]; other site 265669006525 threonine dehydratase; Validated; Region: PRK08639 265669006526 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 265669006527 tetramer interface [polypeptide binding]; other site 265669006528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669006529 catalytic residue [active] 265669006530 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 265669006531 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 265669006532 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 265669006533 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 265669006534 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 265669006535 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 265669006536 Transcriptional regulators [Transcription]; Region: PurR; COG1609 265669006537 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 265669006538 DNA binding site [nucleotide binding] 265669006539 domain linker motif; other site 265669006540 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 265669006541 dimerization interface [polypeptide binding]; other site 265669006542 ligand binding site [chemical binding]; other site 265669006543 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 265669006544 intersubunit interface [polypeptide binding]; other site 265669006545 active site 265669006546 catalytic residue [active] 265669006547 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 265669006548 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 265669006549 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 265669006550 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 265669006551 active pocket/dimerization site; other site 265669006552 active site 265669006553 phosphorylation site [posttranslational modification] 265669006554 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 265669006555 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 265669006556 putative active site [active] 265669006557 SIS domain; Region: SIS; pfam01380 265669006558 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 265669006559 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 265669006560 dimer interface [polypeptide binding]; other site 265669006561 active site 265669006562 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 265669006563 dimer interface [polypeptide binding]; other site 265669006564 active site 265669006565 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 265669006566 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 265669006567 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 265669006568 active site 265669006569 phosphorylation site [posttranslational modification] 265669006570 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 265669006571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669006572 DNA-binding site [nucleotide binding]; DNA binding site 265669006573 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 265669006574 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 265669006575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669006576 DNA-binding site [nucleotide binding]; DNA binding site 265669006577 UTRA domain; Region: UTRA; pfam07702 265669006578 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 265669006579 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 265669006580 active site 265669006581 catalytic tetrad [active] 265669006582 acetolactate synthase; Reviewed; Region: PRK08617 265669006583 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 265669006584 PYR/PP interface [polypeptide binding]; other site 265669006585 dimer interface [polypeptide binding]; other site 265669006586 TPP binding site [chemical binding]; other site 265669006587 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 265669006588 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 265669006589 TPP-binding site [chemical binding]; other site 265669006590 dimer interface [polypeptide binding]; other site 265669006591 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 265669006592 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 265669006593 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 265669006594 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 265669006595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669006596 dimer interface [polypeptide binding]; other site 265669006597 conserved gate region; other site 265669006598 ABC-ATPase subunit interface; other site 265669006599 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 265669006600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669006601 dimer interface [polypeptide binding]; other site 265669006602 conserved gate region; other site 265669006603 ABC-ATPase subunit interface; other site 265669006604 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 265669006605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669006606 active site 265669006607 phosphorylation site [posttranslational modification] 265669006608 intermolecular recognition site; other site 265669006609 dimerization interface [polypeptide binding]; other site 265669006610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 265669006611 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 265669006612 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 265669006613 dimerization interface [polypeptide binding]; other site 265669006614 Histidine kinase; Region: His_kinase; pfam06580 265669006615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669006616 ATP binding site [chemical binding]; other site 265669006617 Mg2+ binding site [ion binding]; other site 265669006618 G-X-G motif; other site 265669006619 Predicted integral membrane protein [Function unknown]; Region: COG5578 265669006620 Uncharacterized conserved protein [Function unknown]; Region: COG3538 265669006621 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 265669006622 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 265669006623 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 265669006624 active site 265669006625 metal binding site [ion binding]; metal-binding site 265669006626 homodimer interface [polypeptide binding]; other site 265669006627 catalytic site [active] 265669006628 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 265669006629 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 265669006630 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 265669006631 active site 265669006632 catalytic site [active] 265669006633 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 265669006634 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 265669006635 DNA-binding site [nucleotide binding]; DNA binding site 265669006636 RNA-binding motif; other site 265669006637 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 265669006638 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 265669006639 active site 265669006640 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 265669006641 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 265669006642 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 265669006643 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 265669006644 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 265669006645 active site 265669006646 HIGH motif; other site 265669006647 nucleotide binding site [chemical binding]; other site 265669006648 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 265669006649 active site 265669006650 KMSKS motif; other site 265669006651 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 265669006652 tRNA binding surface [nucleotide binding]; other site 265669006653 anticodon binding site; other site 265669006654 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 265669006655 DivIVA protein; Region: DivIVA; pfam05103 265669006656 DivIVA domain; Region: DivI1A_domain; TIGR03544 265669006657 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 265669006658 HTH domain; Region: HTH_11; pfam08279 265669006659 3H domain; Region: 3H; pfam02829 265669006660 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 265669006661 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 265669006662 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 265669006663 catalytic residue [active] 265669006664 L-aspartate oxidase; Provisional; Region: PRK08071 265669006665 L-aspartate oxidase; Provisional; Region: PRK06175 265669006666 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 265669006667 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 265669006668 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 265669006669 dimerization interface [polypeptide binding]; other site 265669006670 active site 265669006671 quinolinate synthetase; Provisional; Region: PRK09375 265669006672 Transposase; Region: HTH_Tnp_1; cl17663 265669006673 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 265669006674 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669006675 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669006676 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669006677 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 265669006678 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669006679 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669006680 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669006681 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669006682 Leucine rich repeat; Region: LRR_8; pfam13855 265669006683 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669006684 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 265669006685 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669006686 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669006687 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669006688 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 265669006689 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669006690 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669006691 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669006692 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 265669006693 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 265669006694 Mga helix-turn-helix domain; Region: Mga; pfam05043 265669006695 Methyltransferase domain; Region: Methyltransf_31; pfam13847 265669006696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669006697 S-adenosylmethionine binding site [chemical binding]; other site 265669006698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 265669006699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 265669006700 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 265669006701 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 265669006702 RNA binding surface [nucleotide binding]; other site 265669006703 YGGT family; Region: YGGT; pfam02325 265669006704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 265669006705 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 265669006706 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 265669006707 catalytic residue [active] 265669006708 cell division protein FtsZ; Validated; Region: PRK09330 265669006709 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 265669006710 nucleotide binding site [chemical binding]; other site 265669006711 SulA interaction site; other site 265669006712 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 265669006713 Cell division protein FtsA; Region: FtsA; smart00842 265669006714 Cell division protein FtsA; Region: FtsA; pfam14450 265669006715 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 265669006716 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 265669006717 Cell division protein FtsQ; Region: FtsQ; pfam03799 265669006718 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 265669006719 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 265669006720 active site 265669006721 homodimer interface [polypeptide binding]; other site 265669006722 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 265669006723 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 265669006724 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 265669006725 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 265669006726 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 265669006727 Mg++ binding site [ion binding]; other site 265669006728 putative catalytic motif [active] 265669006729 putative substrate binding site [chemical binding]; other site 265669006730 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 265669006731 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 265669006732 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 265669006733 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 265669006734 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 265669006735 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 265669006736 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 265669006737 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 265669006738 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 265669006739 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 265669006740 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 265669006741 MraW methylase family; Region: Methyltransf_5; pfam01795 265669006742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 265669006743 MraZ protein; Region: MraZ; pfam02381 265669006744 MraZ protein; Region: MraZ; pfam02381 265669006745 Major Facilitator Superfamily; Region: MFS_1; pfam07690 265669006746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669006747 putative substrate translocation pore; other site 265669006748 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 265669006749 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 265669006750 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 265669006751 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 265669006752 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 265669006753 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 265669006754 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 265669006755 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 265669006756 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 265669006757 hypothetical protein; Provisional; Region: PRK13670 265669006758 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 265669006759 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 265669006760 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 265669006761 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669006762 Walker A/P-loop; other site 265669006763 ATP binding site [chemical binding]; other site 265669006764 Q-loop/lid; other site 265669006765 ABC transporter signature motif; other site 265669006766 Walker B; other site 265669006767 D-loop; other site 265669006768 H-loop/switch region; other site 265669006769 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 265669006770 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 265669006771 protein binding site [polypeptide binding]; other site 265669006772 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 265669006773 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 265669006774 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 265669006775 active site 265669006776 (T/H)XGH motif; other site 265669006777 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 265669006778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669006779 S-adenosylmethionine binding site [chemical binding]; other site 265669006780 hypothetical protein; Provisional; Region: PRK02886 265669006781 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 265669006782 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 265669006783 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 265669006784 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 265669006785 UbiA prenyltransferase family; Region: UbiA; pfam01040 265669006786 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 265669006787 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 265669006788 Ion transport protein; Region: Ion_trans; pfam00520 265669006789 Ion channel; Region: Ion_trans_2; pfam07885 265669006790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 265669006791 MOSC domain; Region: MOSC; pfam03473 265669006792 3-alpha domain; Region: 3-alpha; pfam03475 265669006793 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 265669006794 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 265669006795 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 265669006796 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 265669006797 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 265669006798 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 265669006799 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 265669006800 active site 265669006801 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 265669006802 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 265669006803 ring oligomerisation interface [polypeptide binding]; other site 265669006804 ATP/Mg binding site [chemical binding]; other site 265669006805 stacking interactions; other site 265669006806 hinge regions; other site 265669006807 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 265669006808 oligomerisation interface [polypeptide binding]; other site 265669006809 mobile loop; other site 265669006810 roof hairpin; other site 265669006811 CAAX protease self-immunity; Region: Abi; pfam02517 265669006812 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 265669006813 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 265669006814 CoA binding domain; Region: CoA_binding; pfam02629 265669006815 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 265669006816 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 265669006817 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 265669006818 ABC transporter; Region: ABC_tran_2; pfam12848 265669006819 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 265669006820 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 265669006821 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 265669006822 UGMP family protein; Validated; Region: PRK09604 265669006823 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 265669006824 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 265669006825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669006826 Coenzyme A binding pocket [chemical binding]; other site 265669006827 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 265669006828 Glycoprotease family; Region: Peptidase_M22; pfam00814 265669006829 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 265669006830 camphor resistance protein CrcB; Provisional; Region: PRK14214 265669006831 camphor resistance protein CrcB; Provisional; Region: PRK14231 265669006832 Uncharacterized conserved protein [Function unknown]; Region: COG4832 265669006833 Cna protein B-type domain; Region: Cna_B; pfam05738 265669006834 Cna protein B-type domain; Region: Cna_B; pfam05738 265669006835 Cna protein B-type domain; Region: Cna_B; pfam05738 265669006836 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669006837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669006838 non-specific DNA binding site [nucleotide binding]; other site 265669006839 salt bridge; other site 265669006840 sequence-specific DNA binding site [nucleotide binding]; other site 265669006841 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 265669006842 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 265669006843 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 265669006844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 265669006845 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 265669006846 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 265669006847 substrate binding pocket [chemical binding]; other site 265669006848 argininosuccinate synthase; Provisional; Region: PRK13820 265669006849 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 265669006850 ANP binding site [chemical binding]; other site 265669006851 Substrate Binding Site II [chemical binding]; other site 265669006852 Substrate Binding Site I [chemical binding]; other site 265669006853 argininosuccinate lyase; Provisional; Region: PRK00855 265669006854 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 265669006855 active sites [active] 265669006856 tetramer interface [polypeptide binding]; other site 265669006857 BCCT family transporter; Region: BCCT; pfam02028 265669006858 hypothetical protein; Provisional; Region: PRK06357 265669006859 active site 265669006860 intersubunit interface [polypeptide binding]; other site 265669006861 Zn2+ binding site [ion binding]; other site 265669006862 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 265669006863 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 265669006864 putative substrate binding site [chemical binding]; other site 265669006865 putative ATP binding site [chemical binding]; other site 265669006866 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 265669006867 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 265669006868 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 265669006869 active site 265669006870 P-loop; other site 265669006871 phosphorylation site [posttranslational modification] 265669006872 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669006873 active site 265669006874 phosphorylation site [posttranslational modification] 265669006875 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 265669006876 PRD domain; Region: PRD; pfam00874 265669006877 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 265669006878 active site 265669006879 P-loop; other site 265669006880 phosphorylation site [posttranslational modification] 265669006881 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 265669006882 active site 265669006883 phosphorylation site [posttranslational modification] 265669006884 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 265669006885 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669006886 DNA-binding site [nucleotide binding]; DNA binding site 265669006887 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 265669006888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669006889 homodimer interface [polypeptide binding]; other site 265669006890 catalytic residue [active] 265669006891 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 265669006892 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 265669006893 active site 265669006894 multimer interface [polypeptide binding]; other site 265669006895 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 265669006896 conserved cys residue [active] 265669006897 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 265669006898 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 265669006899 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 265669006900 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 265669006901 G1 box; other site 265669006902 GTP/Mg2+ binding site [chemical binding]; other site 265669006903 Switch I region; other site 265669006904 G2 box; other site 265669006905 G3 box; other site 265669006906 Switch II region; other site 265669006907 G4 box; other site 265669006908 G5 box; other site 265669006909 Nucleoside recognition; Region: Gate; pfam07670 265669006910 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 265669006911 Nucleoside recognition; Region: Gate; pfam07670 265669006912 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 265669006913 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 265669006914 putative active site [active] 265669006915 putative metal binding site [ion binding]; other site 265669006916 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 265669006917 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 265669006918 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 265669006919 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 265669006920 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 265669006921 active site 265669006922 dimer interface [polypeptide binding]; other site 265669006923 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 265669006924 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 265669006925 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 265669006926 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 265669006927 dimer interface [polypeptide binding]; other site 265669006928 FMN binding site [chemical binding]; other site 265669006929 NADPH bind site [chemical binding]; other site 265669006930 Helix-turn-helix domain; Region: HTH_17; pfam12728 265669006931 putative heme peroxidase; Provisional; Region: PRK12276 265669006932 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 265669006933 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 265669006934 Walker A/P-loop; other site 265669006935 ATP binding site [chemical binding]; other site 265669006936 Q-loop/lid; other site 265669006937 ABC transporter signature motif; other site 265669006938 Walker B; other site 265669006939 D-loop; other site 265669006940 H-loop/switch region; other site 265669006941 FtsX-like permease family; Region: FtsX; pfam02687 265669006942 FtsX-like permease family; Region: FtsX; pfam02687 265669006943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669006944 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 265669006945 Coenzyme A binding pocket [chemical binding]; other site 265669006946 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 265669006947 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 265669006948 active site 265669006949 substrate binding site [chemical binding]; other site 265669006950 metal binding site [ion binding]; metal-binding site 265669006951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 265669006952 YbbR-like protein; Region: YbbR; pfam07949 265669006953 YbbR-like protein; Region: YbbR; pfam07949 265669006954 YbbR-like protein; Region: YbbR; pfam07949 265669006955 Uncharacterized conserved protein [Function unknown]; Region: COG1624 265669006956 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 265669006957 maltose phosphorylase; Provisional; Region: PRK13807 265669006958 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 265669006959 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 265669006960 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 265669006961 Predicted integral membrane protein [Function unknown]; Region: COG5521 265669006962 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 265669006963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669006964 dimer interface [polypeptide binding]; other site 265669006965 conserved gate region; other site 265669006966 putative PBP binding loops; other site 265669006967 ABC-ATPase subunit interface; other site 265669006968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669006969 dimer interface [polypeptide binding]; other site 265669006970 conserved gate region; other site 265669006971 putative PBP binding loops; other site 265669006972 ABC-ATPase subunit interface; other site 265669006973 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 265669006974 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 265669006975 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 265669006976 homodimer interface [polypeptide binding]; other site 265669006977 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 265669006978 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 265669006979 active site 265669006980 homodimer interface [polypeptide binding]; other site 265669006981 catalytic site [active] 265669006982 CAAX protease self-immunity; Region: Abi; cl00558 265669006983 Transcriptional regulators [Transcription]; Region: PurR; COG1609 265669006984 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 265669006985 DNA binding site [nucleotide binding] 265669006986 domain linker motif; other site 265669006987 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 265669006988 ligand binding site [chemical binding]; other site 265669006989 dimerization interface [polypeptide binding]; other site 265669006990 Amino acid permease; Region: AA_permease_2; pfam13520 265669006991 K+ potassium transporter; Region: K_trans; cl15781 265669006992 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669006993 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 265669006994 ligand binding site [chemical binding]; other site 265669006995 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669006996 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 265669006997 ligand binding site [chemical binding]; other site 265669006998 flexible hinge region; other site 265669006999 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 265669007000 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 265669007001 intersubunit interface [polypeptide binding]; other site 265669007002 active site 265669007003 zinc binding site [ion binding]; other site 265669007004 Na+ binding site [ion binding]; other site 265669007005 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 265669007006 intersubunit interface [polypeptide binding]; other site 265669007007 active site 265669007008 zinc binding site [ion binding]; other site 265669007009 Na+ binding site [ion binding]; other site 265669007010 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 265669007011 HTH domain; Region: HTH_11; pfam08279 265669007012 Mga helix-turn-helix domain; Region: Mga; pfam05043 265669007013 PRD domain; Region: PRD; pfam00874 265669007014 PRD domain; Region: PRD; pfam00874 265669007015 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 265669007016 active site 265669007017 P-loop; other site 265669007018 phosphorylation site [posttranslational modification] 265669007019 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 265669007020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669007021 Walker A/P-loop; other site 265669007022 ATP binding site [chemical binding]; other site 265669007023 Q-loop/lid; other site 265669007024 ABC transporter signature motif; other site 265669007025 Walker B; other site 265669007026 D-loop; other site 265669007027 H-loop/switch region; other site 265669007028 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 265669007029 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 265669007030 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 265669007031 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669007032 Coenzyme A binding pocket [chemical binding]; other site 265669007033 Transcriptional regulators [Transcription]; Region: GntR; COG1802 265669007034 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 265669007035 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 265669007036 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 265669007037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669007038 DNA-binding site [nucleotide binding]; DNA binding site 265669007039 UTRA domain; Region: UTRA; pfam07702 265669007040 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 265669007041 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 265669007042 Transcriptional regulator [Transcription]; Region: LysR; COG0583 265669007043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 265669007044 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 265669007045 putative dimerization interface [polypeptide binding]; other site 265669007046 Predicted membrane protein [Function unknown]; Region: COG2855 265669007047 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 265669007048 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 265669007049 putative metal binding site [ion binding]; other site 265669007050 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 265669007051 homodimer interface [polypeptide binding]; other site 265669007052 chemical substrate binding site [chemical binding]; other site 265669007053 oligomer interface [polypeptide binding]; other site 265669007054 metal binding site [ion binding]; metal-binding site 265669007055 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 265669007056 catalytic residues [active] 265669007057 flavodoxin; Provisional; Region: PRK09271 265669007058 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 265669007059 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 265669007060 dimer interface [polypeptide binding]; other site 265669007061 putative radical transfer pathway; other site 265669007062 diiron center [ion binding]; other site 265669007063 tyrosyl radical; other site 265669007064 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 265669007065 Class I ribonucleotide reductase; Region: RNR_I; cd01679 265669007066 active site 265669007067 dimer interface [polypeptide binding]; other site 265669007068 catalytic residues [active] 265669007069 effector binding site; other site 265669007070 R2 peptide binding site; other site 265669007071 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 265669007072 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 265669007073 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 265669007074 SCP-2 sterol transfer family; Region: SCP2; cl01225 265669007075 CsbD-like; Region: CsbD; cl17424 265669007076 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 265669007077 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 265669007078 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 265669007079 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 265669007080 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 265669007081 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 265669007082 conserved cys residue [active] 265669007083 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 265669007084 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 265669007085 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 265669007086 Cupin; Region: Cupin_1; pfam00190 265669007087 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 265669007088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 265669007089 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669007090 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669007091 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 265669007092 ligand binding site [chemical binding]; other site 265669007093 flexible hinge region; other site 265669007094 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 265669007095 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 265669007096 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 265669007097 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 265669007098 dimer interface [polypeptide binding]; other site 265669007099 active site 265669007100 metal binding site [ion binding]; metal-binding site 265669007101 glutathione binding site [chemical binding]; other site 265669007102 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 265669007103 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 265669007104 FMN binding site [chemical binding]; other site 265669007105 substrate binding site [chemical binding]; other site 265669007106 putative catalytic residue [active] 265669007107 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 265669007108 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 265669007109 Coenzyme A transferase; Region: CoA_trans; smart00882 265669007110 Coenzyme A transferase; Region: CoA_trans; cl17247 265669007111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669007112 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 265669007113 Walker A motif; other site 265669007114 ATP binding site [chemical binding]; other site 265669007115 Walker B motif; other site 265669007116 arginine finger; other site 265669007117 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 265669007118 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 265669007119 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 265669007120 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 265669007121 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 265669007122 metal binding site [ion binding]; metal-binding site 265669007123 active site 265669007124 I-site; other site 265669007125 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 265669007126 classical (c) SDRs; Region: SDR_c; cd05233 265669007127 NAD(P) binding site [chemical binding]; other site 265669007128 active site 265669007129 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 265669007130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 265669007131 Tic20-like protein; Region: Tic20; pfam09685 265669007132 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 265669007133 Cna protein B-type domain; Region: Cna_B; pfam05738 265669007134 Collagen binding domain; Region: Collagen_bind; pfam05737 265669007135 Cna protein B-type domain; Region: Cna_B; pfam05738 265669007136 Cna protein B-type domain; Region: Cna_B; pfam05738 265669007137 Cna protein B-type domain; Region: Cna_B; pfam05738 265669007138 Cna protein B-type domain; Region: Cna_B; pfam05738 265669007139 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669007140 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 265669007141 Cna protein B-type domain; Region: Cna_B; pfam05738 265669007142 Collagen binding domain; Region: Collagen_bind; pfam05737 265669007143 Cna protein B-type domain; Region: Cna_B; pfam05738 265669007144 Cna protein B-type domain; Region: Cna_B; pfam05738 265669007145 Cna protein B-type domain; Region: Cna_B; pfam05738 265669007146 Cna protein B-type domain; Region: Cna_B; pfam05738 265669007147 Cna protein B-type domain; Region: Cna_B; pfam05738 265669007148 Cna protein B-type domain; Region: Cna_B; pfam05738 265669007149 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669007150 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669007151 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669007152 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669007153 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669007154 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 265669007155 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 265669007156 active site 265669007157 catalytic site [active] 265669007158 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 265669007159 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 265669007160 Walker A/P-loop; other site 265669007161 ATP binding site [chemical binding]; other site 265669007162 Q-loop/lid; other site 265669007163 ABC transporter signature motif; other site 265669007164 Walker B; other site 265669007165 D-loop; other site 265669007166 H-loop/switch region; other site 265669007167 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 265669007168 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 265669007169 ABC-ATPase subunit interface; other site 265669007170 dimer interface [polypeptide binding]; other site 265669007171 putative PBP binding regions; other site 265669007172 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 265669007173 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 265669007174 intersubunit interface [polypeptide binding]; other site 265669007175 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 265669007176 heme-binding site [chemical binding]; other site 265669007177 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 265669007178 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 265669007179 heme-binding site [chemical binding]; other site 265669007180 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 265669007181 heme-binding site [chemical binding]; other site 265669007182 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 265669007183 heme uptake protein IsdC; Region: IsdC; TIGR03656 265669007184 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 265669007185 heme-binding site [chemical binding]; other site 265669007186 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 265669007187 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 265669007188 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 265669007189 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 265669007190 active site 265669007191 Zn binding site [ion binding]; other site 265669007192 Competence protein CoiA-like family; Region: CoiA; cl11541 265669007193 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 265669007194 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 265669007195 ArsC family; Region: ArsC; pfam03960 265669007196 putative catalytic residues [active] 265669007197 thiol/disulfide switch; other site 265669007198 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 265669007199 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 265669007200 Walker A/P-loop; other site 265669007201 ATP binding site [chemical binding]; other site 265669007202 Q-loop/lid; other site 265669007203 ABC transporter signature motif; other site 265669007204 Walker B; other site 265669007205 D-loop; other site 265669007206 H-loop/switch region; other site 265669007207 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 265669007208 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 265669007209 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 265669007210 Walker A/P-loop; other site 265669007211 ATP binding site [chemical binding]; other site 265669007212 Q-loop/lid; other site 265669007213 ABC transporter signature motif; other site 265669007214 Walker B; other site 265669007215 D-loop; other site 265669007216 H-loop/switch region; other site 265669007217 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 265669007218 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 265669007219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669007220 dimer interface [polypeptide binding]; other site 265669007221 conserved gate region; other site 265669007222 putative PBP binding loops; other site 265669007223 ABC-ATPase subunit interface; other site 265669007224 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 265669007225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669007226 dimer interface [polypeptide binding]; other site 265669007227 conserved gate region; other site 265669007228 putative PBP binding loops; other site 265669007229 ABC-ATPase subunit interface; other site 265669007230 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 265669007231 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 265669007232 peptide binding site [polypeptide binding]; other site 265669007233 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 265669007234 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 265669007235 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 265669007236 active site 265669007237 HIGH motif; other site 265669007238 dimer interface [polypeptide binding]; other site 265669007239 KMSKS motif; other site 265669007240 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 265669007241 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 265669007242 MarR family; Region: MarR; pfam01047 265669007243 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 265669007244 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 265669007245 dimer interface [polypeptide binding]; other site 265669007246 active site 265669007247 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 265669007248 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 265669007249 dimer interface [polypeptide binding]; other site 265669007250 active site 265669007251 CoA binding pocket [chemical binding]; other site 265669007252 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 265669007253 SH3-like domain; Region: SH3_8; pfam13457 265669007254 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 265669007255 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 265669007256 catalytic core [active] 265669007257 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 265669007258 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 265669007259 Clp amino terminal domain; Region: Clp_N; pfam02861 265669007260 Clp amino terminal domain; Region: Clp_N; pfam02861 265669007261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669007262 Walker A motif; other site 265669007263 ATP binding site [chemical binding]; other site 265669007264 Walker B motif; other site 265669007265 arginine finger; other site 265669007266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669007267 Walker A motif; other site 265669007268 ATP binding site [chemical binding]; other site 265669007269 Walker B motif; other site 265669007270 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 265669007271 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 265669007272 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 265669007273 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 265669007274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669007275 active site 265669007276 motif I; other site 265669007277 motif II; other site 265669007278 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 265669007279 Predicted acetyltransferase [General function prediction only]; Region: COG3393 265669007280 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 265669007281 ferrochelatase; Provisional; Region: PRK12435 265669007282 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 265669007283 C-terminal domain interface [polypeptide binding]; other site 265669007284 active site 265669007285 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 265669007286 active site 265669007287 N-terminal domain interface [polypeptide binding]; other site 265669007288 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 265669007289 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 265669007290 substrate binding site [chemical binding]; other site 265669007291 active site 265669007292 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 265669007293 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 265669007294 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 265669007295 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 265669007296 Walker A/P-loop; other site 265669007297 ATP binding site [chemical binding]; other site 265669007298 Q-loop/lid; other site 265669007299 ABC transporter signature motif; other site 265669007300 Walker B; other site 265669007301 D-loop; other site 265669007302 H-loop/switch region; other site 265669007303 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 265669007304 HIT family signature motif; other site 265669007305 catalytic residue [active] 265669007306 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 265669007307 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 265669007308 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 265669007309 SurA N-terminal domain; Region: SurA_N_3; cl07813 265669007310 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 265669007311 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 265669007312 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 265669007313 generic binding surface II; other site 265669007314 generic binding surface I; other site 265669007315 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 265669007316 Zn2+ binding site [ion binding]; other site 265669007317 Mg2+ binding site [ion binding]; other site 265669007318 Uncharacterized conserved protein [Function unknown]; Region: COG4717 265669007319 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 265669007320 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 265669007321 active site 265669007322 metal binding site [ion binding]; metal-binding site 265669007323 DNA binding site [nucleotide binding] 265669007324 hypothetical protein; Provisional; Region: PRK13676 265669007325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 265669007326 fumarate hydratase; Reviewed; Region: fumC; PRK00485 265669007327 Class II fumarases; Region: Fumarase_classII; cd01362 265669007328 active site 265669007329 tetramer interface [polypeptide binding]; other site 265669007330 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 265669007331 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 265669007332 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 265669007333 Walker A/P-loop; other site 265669007334 ATP binding site [chemical binding]; other site 265669007335 Q-loop/lid; other site 265669007336 ABC transporter signature motif; other site 265669007337 Walker B; other site 265669007338 D-loop; other site 265669007339 H-loop/switch region; other site 265669007340 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 265669007341 Transglycosylase; Region: Transgly; pfam00912 265669007342 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 265669007343 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 265669007344 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 265669007345 Low molecular weight phosphatase family; Region: LMWPc; cl00105 265669007346 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 265669007347 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 265669007348 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 265669007349 Domain of unknown function DUF21; Region: DUF21; pfam01595 265669007350 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 265669007351 Transporter associated domain; Region: CorC_HlyC; smart01091 265669007352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 265669007353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 265669007354 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 265669007355 putative dimerization interface [polypeptide binding]; other site 265669007356 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 265669007357 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 265669007358 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 265669007359 active site 265669007360 FMN binding site [chemical binding]; other site 265669007361 substrate binding site [chemical binding]; other site 265669007362 putative catalytic residue [active] 265669007363 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 265669007364 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 265669007365 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 265669007366 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 265669007367 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 265669007368 shikimate binding site; other site 265669007369 NAD(P) binding site [chemical binding]; other site 265669007370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669007371 putative substrate translocation pore; other site 265669007372 Major Facilitator Superfamily; Region: MFS_1; pfam07690 265669007373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669007374 Major Facilitator Superfamily; Region: MFS_1; pfam07690 265669007375 putative substrate translocation pore; other site 265669007376 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 265669007377 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 265669007378 Walker A/P-loop; other site 265669007379 ATP binding site [chemical binding]; other site 265669007380 Q-loop/lid; other site 265669007381 ABC transporter signature motif; other site 265669007382 Walker B; other site 265669007383 D-loop; other site 265669007384 H-loop/switch region; other site 265669007385 Predicted transcriptional regulators [Transcription]; Region: COG1725 265669007386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 265669007387 DNA-binding site [nucleotide binding]; DNA binding site 265669007388 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 265669007389 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 265669007390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 265669007391 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 265669007392 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 265669007393 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 265669007394 active site 265669007395 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 265669007396 putative dimer interface [polypeptide binding]; other site 265669007397 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 265669007398 ligand binding site [chemical binding]; other site 265669007399 Zn binding site [ion binding]; other site 265669007400 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 265669007401 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 265669007402 active site 265669007403 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 265669007404 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 265669007405 active site 265669007406 catalytic tetrad [active] 265669007407 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 265669007408 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 265669007409 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 265669007410 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 265669007411 substrate binding pocket [chemical binding]; other site 265669007412 membrane-bound complex binding site; other site 265669007413 hinge residues; other site 265669007414 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 265669007415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669007416 dimer interface [polypeptide binding]; other site 265669007417 conserved gate region; other site 265669007418 putative PBP binding loops; other site 265669007419 ABC-ATPase subunit interface; other site 265669007420 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 265669007421 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 265669007422 Walker A/P-loop; other site 265669007423 ATP binding site [chemical binding]; other site 265669007424 Q-loop/lid; other site 265669007425 ABC transporter signature motif; other site 265669007426 Walker B; other site 265669007427 D-loop; other site 265669007428 H-loop/switch region; other site 265669007429 aspartate aminotransferase; Provisional; Region: PRK06348 265669007430 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 265669007431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669007432 homodimer interface [polypeptide binding]; other site 265669007433 catalytic residue [active] 265669007434 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 265669007435 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 265669007436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669007437 motif II; other site 265669007438 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 265669007439 intracellular protease, PfpI family; Region: PfpI; TIGR01382 265669007440 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 265669007441 proposed catalytic triad [active] 265669007442 conserved cys residue [active] 265669007443 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 265669007444 methionine cluster; other site 265669007445 active site 265669007446 phosphorylation site [posttranslational modification] 265669007447 metal binding site [ion binding]; metal-binding site 265669007448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669007449 Coenzyme A binding pocket [chemical binding]; other site 265669007450 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 265669007451 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 265669007452 esterase; Provisional; Region: PRK10566 265669007453 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 265669007454 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 265669007455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 265669007456 motif II; other site 265669007457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669007458 Uncharacterized conserved protein [Function unknown]; Region: COG1284 265669007459 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 265669007460 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 265669007461 hypothetical protein; Provisional; Region: PRK13673 265669007462 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 265669007463 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 265669007464 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 265669007465 Part of AAA domain; Region: AAA_19; pfam13245 265669007466 Family description; Region: UvrD_C_2; pfam13538 265669007467 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 265669007468 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 265669007469 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 265669007470 IDEAL domain; Region: IDEAL; pfam08858 265669007471 ComK protein; Region: ComK; cl11560 265669007472 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 265669007473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669007474 non-specific DNA binding site [nucleotide binding]; other site 265669007475 salt bridge; other site 265669007476 sequence-specific DNA binding site [nucleotide binding]; other site 265669007477 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 265669007478 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669007479 active site 265669007480 phosphorylation site [posttranslational modification] 265669007481 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 265669007482 active site 265669007483 P-loop; other site 265669007484 phosphorylation site [posttranslational modification] 265669007485 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 265669007486 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 265669007487 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 265669007488 putative substrate binding site [chemical binding]; other site 265669007489 putative ATP binding site [chemical binding]; other site 265669007490 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 265669007491 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 265669007492 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 265669007493 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 265669007494 trimer interface [polypeptide binding]; other site 265669007495 active site 265669007496 G bulge; other site 265669007497 Uncharacterized conserved protein [Function unknown]; Region: COG1683 265669007498 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 265669007499 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 265669007500 non-specific DNA interactions [nucleotide binding]; other site 265669007501 DNA binding site [nucleotide binding] 265669007502 sequence specific DNA binding site [nucleotide binding]; other site 265669007503 putative cAMP binding site [chemical binding]; other site 265669007504 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 265669007505 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 265669007506 substrate binding site [chemical binding]; other site 265669007507 ATP binding site [chemical binding]; other site 265669007508 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 265669007509 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 265669007510 RNA binding surface [nucleotide binding]; other site 265669007511 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 265669007512 active site 265669007513 uracil binding [chemical binding]; other site 265669007514 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 265669007515 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 265669007516 active site 265669007517 non-prolyl cis peptide bond; other site 265669007518 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 265669007519 catalytic residues [active] 265669007520 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 265669007521 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 265669007522 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 265669007523 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 265669007524 Walker A/P-loop; other site 265669007525 ATP binding site [chemical binding]; other site 265669007526 Q-loop/lid; other site 265669007527 ABC transporter signature motif; other site 265669007528 Walker B; other site 265669007529 D-loop; other site 265669007530 H-loop/switch region; other site 265669007531 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 265669007532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669007533 dimer interface [polypeptide binding]; other site 265669007534 conserved gate region; other site 265669007535 putative PBP binding loops; other site 265669007536 ABC-ATPase subunit interface; other site 265669007537 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 265669007538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669007539 dimer interface [polypeptide binding]; other site 265669007540 conserved gate region; other site 265669007541 putative PBP binding loops; other site 265669007542 ABC-ATPase subunit interface; other site 265669007543 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 265669007544 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 265669007545 substrate binding pocket [chemical binding]; other site 265669007546 membrane-bound complex binding site; other site 265669007547 hinge residues; other site 265669007548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669007549 Coenzyme A binding pocket [chemical binding]; other site 265669007550 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 265669007551 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 265669007552 Transcriptional regulator [Transcription]; Region: LysR; COG0583 265669007553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 265669007554 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 265669007555 dimerization interface [polypeptide binding]; other site 265669007556 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 265669007557 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 265669007558 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 265669007559 active site 265669007560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669007561 Major Facilitator Superfamily; Region: MFS_1; pfam07690 265669007562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669007563 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 265669007564 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 265669007565 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 265669007566 active site 265669007567 trimer interface [polypeptide binding]; other site 265669007568 allosteric site; other site 265669007569 active site lid [active] 265669007570 hexamer (dimer of trimers) interface [polypeptide binding]; other site 265669007571 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 265669007572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 265669007573 Predicted membrane protein [Function unknown]; Region: COG1511 265669007574 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 265669007575 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 265669007576 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 265669007577 Predicted transcriptional regulator [Transcription]; Region: COG1959 265669007578 Transcriptional regulator; Region: Rrf2; pfam02082 265669007579 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 265669007580 L-tyrosine decarboxylase; Provisional; Region: PRK13520 265669007581 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 265669007582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669007583 catalytic residue [active] 265669007584 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 265669007585 Mga helix-turn-helix domain; Region: Mga; pfam05043 265669007586 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 265669007587 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 265669007588 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 265669007589 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 265669007590 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 265669007591 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 265669007592 active site 265669007593 dimer interface [polypeptide binding]; other site 265669007594 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 265669007595 dimer interface [polypeptide binding]; other site 265669007596 active site 265669007597 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 265669007598 nudix motif; other site 265669007599 general stress protein 13; Validated; Region: PRK08059 265669007600 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 265669007601 RNA binding site [nucleotide binding]; other site 265669007602 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 265669007603 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 265669007604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669007605 homodimer interface [polypeptide binding]; other site 265669007606 catalytic residue [active] 265669007607 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 265669007608 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 265669007609 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 265669007610 Walker A/P-loop; other site 265669007611 ATP binding site [chemical binding]; other site 265669007612 Q-loop/lid; other site 265669007613 ABC transporter signature motif; other site 265669007614 Walker B; other site 265669007615 D-loop; other site 265669007616 H-loop/switch region; other site 265669007617 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 265669007618 active site 265669007619 P-loop; other site 265669007620 phosphorylation site [posttranslational modification] 265669007621 aspartate kinase; Reviewed; Region: PRK09034 265669007622 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 265669007623 putative catalytic residues [active] 265669007624 putative nucleotide binding site [chemical binding]; other site 265669007625 putative aspartate binding site [chemical binding]; other site 265669007626 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 265669007627 allosteric regulatory residue; other site 265669007628 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 265669007629 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 265669007630 putative active site [active] 265669007631 putative NTP binding site [chemical binding]; other site 265669007632 putative nucleic acid binding site [nucleotide binding]; other site 265669007633 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 265669007634 active site 265669007635 drug efflux system protein MdtG; Provisional; Region: PRK09874 265669007636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669007637 putative substrate translocation pore; other site 265669007638 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 265669007639 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 265669007640 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 265669007641 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 265669007642 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 265669007643 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 265669007644 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 265669007645 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 265669007646 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 265669007647 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 265669007648 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 265669007649 CoenzymeA binding site [chemical binding]; other site 265669007650 subunit interaction site [polypeptide binding]; other site 265669007651 PHB binding site; other site 265669007652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 265669007653 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 265669007654 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 265669007655 Cl- selectivity filter; other site 265669007656 Cl- binding residues [ion binding]; other site 265669007657 pore gating glutamate residue; other site 265669007658 dimer interface [polypeptide binding]; other site 265669007659 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669007660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 265669007661 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 265669007662 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 265669007663 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 265669007664 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 265669007665 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 265669007666 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 265669007667 NADH(P)-binding; Region: NAD_binding_10; pfam13460 265669007668 NAD(P) binding site [chemical binding]; other site 265669007669 putative active site [active] 265669007670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844 265669007671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 265669007672 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 265669007673 Leucine-rich repeats; other site 265669007674 Substrate binding site [chemical binding]; other site 265669007675 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669007676 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669007677 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669007678 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669007679 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669007680 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669007681 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669007682 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669007683 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 265669007684 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 265669007685 tetramer interfaces [polypeptide binding]; other site 265669007686 binuclear metal-binding site [ion binding]; other site 265669007687 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 265669007688 Domain of unknown function DUF21; Region: DUF21; pfam01595 265669007689 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 265669007690 Transporter associated domain; Region: CorC_HlyC; smart01091 265669007691 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 265669007692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669007693 Coenzyme A binding pocket [chemical binding]; other site 265669007694 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 265669007695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669007696 active site 265669007697 motif I; other site 265669007698 motif II; other site 265669007699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669007700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 265669007701 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 265669007702 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 265669007703 active site 265669007704 metal binding site [ion binding]; metal-binding site 265669007705 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 265669007706 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 265669007707 Predicted membrane protein [Function unknown]; Region: COG4272 265669007708 Uncharacterized conserved protein [Function unknown]; Region: COG1801 265669007709 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 265669007710 FeS assembly protein SufB; Region: sufB; TIGR01980 265669007711 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 265669007712 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 265669007713 trimerization site [polypeptide binding]; other site 265669007714 active site 265669007715 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 265669007716 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 265669007717 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 265669007718 catalytic residue [active] 265669007719 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 265669007720 FeS assembly protein SufD; Region: sufD; TIGR01981 265669007721 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 265669007722 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 265669007723 Walker A/P-loop; other site 265669007724 ATP binding site [chemical binding]; other site 265669007725 Q-loop/lid; other site 265669007726 ABC transporter signature motif; other site 265669007727 Walker B; other site 265669007728 D-loop; other site 265669007729 H-loop/switch region; other site 265669007730 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 265669007731 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 265669007732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669007733 ABC-ATPase subunit interface; other site 265669007734 putative PBP binding loops; other site 265669007735 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 265669007736 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 265669007737 Walker A/P-loop; other site 265669007738 ATP binding site [chemical binding]; other site 265669007739 Q-loop/lid; other site 265669007740 ABC transporter signature motif; other site 265669007741 Walker B; other site 265669007742 D-loop; other site 265669007743 H-loop/switch region; other site 265669007744 NIL domain; Region: NIL; pfam09383 265669007745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 265669007746 dimer interface [polypeptide binding]; other site 265669007747 phosphorylation site [posttranslational modification] 265669007748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669007749 ATP binding site [chemical binding]; other site 265669007750 Mg2+ binding site [ion binding]; other site 265669007751 G-X-G motif; other site 265669007752 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 265669007753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669007754 active site 265669007755 phosphorylation site [posttranslational modification] 265669007756 intermolecular recognition site; other site 265669007757 dimerization interface [polypeptide binding]; other site 265669007758 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 265669007759 DNA binding site [nucleotide binding] 265669007760 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 265669007761 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 265669007762 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 265669007763 catalytic residues [active] 265669007764 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 265669007765 lipoyl attachment site [posttranslational modification]; other site 265669007766 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 265669007767 ArsC family; Region: ArsC; pfam03960 265669007768 putative ArsC-like catalytic residues; other site 265669007769 putative TRX-like catalytic residues [active] 265669007770 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 265669007771 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 265669007772 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 265669007773 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 265669007774 Walker A/P-loop; other site 265669007775 ATP binding site [chemical binding]; other site 265669007776 Q-loop/lid; other site 265669007777 ABC transporter signature motif; other site 265669007778 Walker B; other site 265669007779 D-loop; other site 265669007780 H-loop/switch region; other site 265669007781 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 265669007782 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 265669007783 ABC-ATPase subunit interface; other site 265669007784 dimer interface [polypeptide binding]; other site 265669007785 putative PBP binding regions; other site 265669007786 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 265669007787 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 265669007788 intersubunit interface [polypeptide binding]; other site 265669007789 Predicted esterase [General function prediction only]; Region: COG0627 265669007790 S-formylglutathione hydrolase; Region: PLN02442 265669007791 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 265669007792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669007793 catalytic residue [active] 265669007794 SdpI/YhfL protein family; Region: SdpI; pfam13630 265669007795 CAT RNA binding domain; Region: CAT_RBD; smart01061 265669007796 transcriptional antiterminator BglG; Provisional; Region: PRK09772 265669007797 PRD domain; Region: PRD; pfam00874 265669007798 PRD domain; Region: PRD; pfam00874 265669007799 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 265669007800 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 265669007801 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 265669007802 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 265669007803 Predicted transcriptional regulator [Transcription]; Region: COG2378 265669007804 HTH domain; Region: HTH_11; pfam08279 265669007805 WYL domain; Region: WYL; pfam13280 265669007806 Uncharacterized conserved protein [Function unknown]; Region: COG1434 265669007807 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 265669007808 putative active site [active] 265669007809 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 265669007810 Leucine rich repeat; Region: LRR_8; pfam13855 265669007811 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 265669007812 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 265669007813 active site 265669007814 catalytic site [active] 265669007815 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 265669007816 putative metal binding site [ion binding]; other site 265669007817 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 265669007818 putative metal binding site [ion binding]; other site 265669007819 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 265669007820 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 265669007821 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 265669007822 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 265669007823 active site 265669007824 catalytic site [active] 265669007825 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 265669007826 putative metal binding site [ion binding]; other site 265669007827 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669007828 non-specific DNA binding site [nucleotide binding]; other site 265669007829 salt bridge; other site 265669007830 sequence-specific DNA binding site [nucleotide binding]; other site 265669007831 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 265669007832 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 265669007833 SmpB-tmRNA interface; other site 265669007834 ribonuclease R; Region: RNase_R; TIGR02063 265669007835 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 265669007836 RNB domain; Region: RNB; pfam00773 265669007837 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 265669007838 RNA binding site [nucleotide binding]; other site 265669007839 Esterase/lipase [General function prediction only]; Region: COG1647 265669007840 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 265669007841 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 265669007842 Preprotein translocase SecG subunit; Region: SecG; cl09123 265669007843 Esterase/lipase [General function prediction only]; Region: COG1647 265669007844 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 265669007845 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 265669007846 PGAP1-like protein; Region: PGAP1; pfam07819 265669007847 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 265669007848 enolase; Provisional; Region: eno; PRK00077 265669007849 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 265669007850 dimer interface [polypeptide binding]; other site 265669007851 metal binding site [ion binding]; metal-binding site 265669007852 substrate binding pocket [chemical binding]; other site 265669007853 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 265669007854 phosphoglyceromutase; Provisional; Region: PRK05434 265669007855 triosephosphate isomerase; Provisional; Region: PRK14567 265669007856 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 265669007857 substrate binding site [chemical binding]; other site 265669007858 dimer interface [polypeptide binding]; other site 265669007859 catalytic triad [active] 265669007860 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 265669007861 Phosphoglycerate kinase; Region: PGK; pfam00162 265669007862 substrate binding site [chemical binding]; other site 265669007863 hinge regions; other site 265669007864 ADP binding site [chemical binding]; other site 265669007865 catalytic site [active] 265669007866 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 265669007867 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 265669007868 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 265669007869 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 265669007870 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 265669007871 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 265669007872 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 265669007873 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 265669007874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 265669007875 DNA binding site [nucleotide binding] 265669007876 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 265669007877 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 265669007878 active site 265669007879 dimer interface [polypeptide binding]; other site 265669007880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 265669007881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 265669007882 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 265669007883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 265669007884 Chitin binding domain; Region: Chitin_bind_3; pfam03067 265669007885 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 265669007886 Interdomain contacts; other site 265669007887 Cytokine receptor motif; other site 265669007888 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 265669007889 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 265669007890 Interdomain contacts; other site 265669007891 Cytokine receptor motif; other site 265669007892 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 265669007893 aromatic chitin/cellulose binding site residues [chemical binding]; other site 265669007894 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 265669007895 aromatic chitin/cellulose binding site residues [chemical binding]; other site 265669007896 Clp protease; Region: CLP_protease; pfam00574 265669007897 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 265669007898 oligomer interface [polypeptide binding]; other site 265669007899 active site residues [active] 265669007900 amino acid transporter; Region: 2A0306; TIGR00909 265669007901 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 265669007902 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 265669007903 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 265669007904 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669007905 Substrate binding site [chemical binding]; other site 265669007906 Leucine rich repeat; Region: LRR_8; pfam13855 265669007907 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669007908 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 265669007909 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 265669007910 active site 265669007911 FMN binding site [chemical binding]; other site 265669007912 substrate binding site [chemical binding]; other site 265669007913 homotetramer interface [polypeptide binding]; other site 265669007914 catalytic residue [active] 265669007915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 265669007916 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 265669007917 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 265669007918 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 265669007919 phosphate binding site [ion binding]; other site 265669007920 putative substrate binding pocket [chemical binding]; other site 265669007921 dimer interface [polypeptide binding]; other site 265669007922 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 265669007923 AAA domain; Region: AAA_18; pfam13238 265669007924 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 265669007925 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 265669007926 active site 265669007927 substrate binding site [chemical binding]; other site 265669007928 metal binding site [ion binding]; metal-binding site 265669007929 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 265669007930 active site 265669007931 catalytic residues [active] 265669007932 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 265669007933 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 265669007934 NAD binding site [chemical binding]; other site 265669007935 homodimer interface [polypeptide binding]; other site 265669007936 active site 265669007937 substrate binding site [chemical binding]; other site 265669007938 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 265669007939 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 265669007940 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 265669007941 TPR repeat; Region: TPR_11; pfam13414 265669007942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 265669007943 binding surface 265669007944 TPR motif; other site 265669007945 Tetratricopeptide repeat; Region: TPR_12; pfam13424 265669007946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 265669007947 binding surface 265669007948 TPR motif; other site 265669007949 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 265669007950 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 265669007951 putative trimer interface [polypeptide binding]; other site 265669007952 putative CoA binding site [chemical binding]; other site 265669007953 pyrophosphatase PpaX; Provisional; Region: PRK13288 265669007954 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669007955 motif II; other site 265669007956 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 265669007957 HPr kinase/phosphorylase; Provisional; Region: PRK05428 265669007958 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 265669007959 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 265669007960 Hpr binding site; other site 265669007961 active site 265669007962 homohexamer subunit interaction site [polypeptide binding]; other site 265669007963 Predicted membrane protein [Function unknown]; Region: COG1950 265669007964 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 265669007965 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 265669007966 Uncharacterized conserved protein [Function unknown]; Region: COG3595 265669007967 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 265669007968 Uncharacterized conserved protein [Function unknown]; Region: COG3595 265669007969 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 265669007970 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 265669007971 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 265669007972 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 265669007973 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 265669007974 excinuclease ABC subunit B; Provisional; Region: PRK05298 265669007975 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 265669007976 ATP binding site [chemical binding]; other site 265669007977 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 265669007978 nucleotide binding region [chemical binding]; other site 265669007979 ATP-binding site [chemical binding]; other site 265669007980 Ultra-violet resistance protein B; Region: UvrB; pfam12344 265669007981 UvrB/uvrC motif; Region: UVR; pfam02151 265669007982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 265669007983 HD containing hydrolase-like enzyme; Region: HD_2; pfam12917 265669007984 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 265669007985 dimerization interface [polypeptide binding]; other site 265669007986 putative DNA binding site [nucleotide binding]; other site 265669007987 putative Zn2+ binding site [ion binding]; other site 265669007988 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 265669007989 PhoU domain; Region: PhoU; pfam01895 265669007990 PhoU domain; Region: PhoU; pfam01895 265669007991 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 265669007992 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 265669007993 Walker A/P-loop; other site 265669007994 ATP binding site [chemical binding]; other site 265669007995 Q-loop/lid; other site 265669007996 ABC transporter signature motif; other site 265669007997 Walker B; other site 265669007998 D-loop; other site 265669007999 H-loop/switch region; other site 265669008000 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 265669008001 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 265669008002 Walker A/P-loop; other site 265669008003 ATP binding site [chemical binding]; other site 265669008004 Q-loop/lid; other site 265669008005 ABC transporter signature motif; other site 265669008006 Walker B; other site 265669008007 D-loop; other site 265669008008 H-loop/switch region; other site 265669008009 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 265669008010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669008011 dimer interface [polypeptide binding]; other site 265669008012 conserved gate region; other site 265669008013 putative PBP binding loops; other site 265669008014 ABC-ATPase subunit interface; other site 265669008015 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 265669008016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669008017 dimer interface [polypeptide binding]; other site 265669008018 conserved gate region; other site 265669008019 putative PBP binding loops; other site 265669008020 ABC-ATPase subunit interface; other site 265669008021 PBP superfamily domain; Region: PBP_like_2; cl17296 265669008022 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 265669008023 HAMP domain; Region: HAMP; pfam00672 265669008024 dimerization interface [polypeptide binding]; other site 265669008025 PAS domain; Region: PAS; smart00091 265669008026 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 265669008027 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 265669008028 dimer interface [polypeptide binding]; other site 265669008029 phosphorylation site [posttranslational modification] 265669008030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669008031 ATP binding site [chemical binding]; other site 265669008032 Mg2+ binding site [ion binding]; other site 265669008033 G-X-G motif; other site 265669008034 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 265669008035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669008036 active site 265669008037 phosphorylation site [posttranslational modification] 265669008038 intermolecular recognition site; other site 265669008039 dimerization interface [polypeptide binding]; other site 265669008040 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 265669008041 DNA binding site [nucleotide binding] 265669008042 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 265669008043 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 265669008044 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 265669008045 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 265669008046 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 265669008047 putative active site [active] 265669008048 catalytic site [active] 265669008049 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 265669008050 putative active site [active] 265669008051 catalytic site [active] 265669008052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 265669008053 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 265669008054 Peptidase family M23; Region: Peptidase_M23; pfam01551 265669008055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 265669008056 NlpC/P60 family; Region: NLPC_P60; pfam00877 265669008057 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 265669008058 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 265669008059 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 265669008060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669008061 Walker A/P-loop; other site 265669008062 ATP binding site [chemical binding]; other site 265669008063 Q-loop/lid; other site 265669008064 ABC transporter signature motif; other site 265669008065 Walker B; other site 265669008066 D-loop; other site 265669008067 H-loop/switch region; other site 265669008068 Uncharacterized conserved protein [Function unknown]; Region: COG1284 265669008069 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 265669008070 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 265669008071 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 265669008072 peptide chain release factor 2; Validated; Region: prfB; PRK00578 265669008073 This domain is found in peptide chain release factors; Region: PCRF; smart00937 265669008074 RF-1 domain; Region: RF-1; pfam00472 265669008075 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 265669008076 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 265669008077 nucleotide binding region [chemical binding]; other site 265669008078 helicase superfamily c-terminal domain; Region: HELICc; smart00490 265669008079 ATP-binding site [chemical binding]; other site 265669008080 SEC-C motif; Region: SEC-C; pfam02810 265669008081 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 265669008082 30S subunit binding site; other site 265669008083 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 265669008084 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 265669008085 active site 265669008086 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 265669008087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 265669008088 ATP binding site [chemical binding]; other site 265669008089 putative Mg++ binding site [ion binding]; other site 265669008090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 265669008091 nucleotide binding region [chemical binding]; other site 265669008092 ATP-binding site [chemical binding]; other site 265669008093 EDD domain protein, DegV family; Region: DegV; TIGR00762 265669008094 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 265669008095 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 265669008096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669008097 active site 265669008098 phosphorylation site [posttranslational modification] 265669008099 intermolecular recognition site; other site 265669008100 dimerization interface [polypeptide binding]; other site 265669008101 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 265669008102 DNA binding residues [nucleotide binding] 265669008103 dimerization interface [polypeptide binding]; other site 265669008104 Uncharacterized conserved protein [Function unknown]; Region: COG1739 265669008105 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 265669008106 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 265669008107 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 265669008108 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 265669008109 Transcriptional regulator [Transcription]; Region: LytR; COG1316 265669008110 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 265669008111 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 265669008112 Mg++ binding site [ion binding]; other site 265669008113 putative catalytic motif [active] 265669008114 substrate binding site [chemical binding]; other site 265669008115 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 265669008116 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 265669008117 active site 265669008118 octamer interface [polypeptide binding]; other site 265669008119 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 265669008120 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 265669008121 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 265669008122 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 265669008123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 265669008124 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 265669008125 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 265669008126 dimer interface [polypeptide binding]; other site 265669008127 ssDNA binding site [nucleotide binding]; other site 265669008128 tetramer (dimer of dimers) interface [polypeptide binding]; other site 265669008129 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 265669008130 rod shape-determining protein Mbl; Provisional; Region: PRK13928 265669008131 MreB and similar proteins; Region: MreB_like; cd10225 265669008132 nucleotide binding site [chemical binding]; other site 265669008133 Mg binding site [ion binding]; other site 265669008134 putative protofilament interaction site [polypeptide binding]; other site 265669008135 RodZ interaction site [polypeptide binding]; other site 265669008136 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 265669008137 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 265669008138 hinge; other site 265669008139 active site 265669008140 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 265669008141 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 265669008142 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 265669008143 gamma subunit interface [polypeptide binding]; other site 265669008144 epsilon subunit interface [polypeptide binding]; other site 265669008145 LBP interface [polypeptide binding]; other site 265669008146 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 265669008147 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 265669008148 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 265669008149 alpha subunit interaction interface [polypeptide binding]; other site 265669008150 Walker A motif; other site 265669008151 ATP binding site [chemical binding]; other site 265669008152 Walker B motif; other site 265669008153 inhibitor binding site; inhibition site 265669008154 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 265669008155 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 265669008156 core domain interface [polypeptide binding]; other site 265669008157 delta subunit interface [polypeptide binding]; other site 265669008158 epsilon subunit interface [polypeptide binding]; other site 265669008159 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 265669008160 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 265669008161 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 265669008162 beta subunit interaction interface [polypeptide binding]; other site 265669008163 Walker A motif; other site 265669008164 ATP binding site [chemical binding]; other site 265669008165 Walker B motif; other site 265669008166 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 265669008167 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 265669008168 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 265669008169 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 265669008170 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 265669008171 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 265669008172 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 265669008173 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 265669008174 ATP synthase I chain; Region: ATP_synt_I; pfam03899 265669008175 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 265669008176 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 265669008177 active site 265669008178 homodimer interface [polypeptide binding]; other site 265669008179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 265669008180 active site 265669008181 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 265669008182 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 265669008183 dimer interface [polypeptide binding]; other site 265669008184 active site 265669008185 glycine-pyridoxal phosphate binding site [chemical binding]; other site 265669008186 folate binding site [chemical binding]; other site 265669008187 Low molecular weight phosphatase family; Region: LMWPc; cd00115 265669008188 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 265669008189 active site 265669008190 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 265669008191 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 265669008192 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 265669008193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669008194 S-adenosylmethionine binding site [chemical binding]; other site 265669008195 peptide chain release factor 1; Validated; Region: prfA; PRK00591 265669008196 This domain is found in peptide chain release factors; Region: PCRF; smart00937 265669008197 RF-1 domain; Region: RF-1; pfam00472 265669008198 thymidine kinase; Provisional; Region: PRK04296 265669008199 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 265669008200 ATP binding site [chemical binding]; other site 265669008201 Walker A motif; other site 265669008202 Walker B motif; other site 265669008203 homoserine kinase; Provisional; Region: PRK01212 265669008204 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 265669008205 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 265669008206 threonine synthase; Reviewed; Region: PRK06721 265669008207 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 265669008208 homodimer interface [polypeptide binding]; other site 265669008209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669008210 catalytic residue [active] 265669008211 homoserine dehydrogenase; Provisional; Region: PRK06349 265669008212 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 265669008213 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 265669008214 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 265669008215 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 265669008216 Predicted membrane protein [Function unknown]; Region: COG2246 265669008217 GtrA-like protein; Region: GtrA; pfam04138 265669008218 transcription termination factor Rho; Provisional; Region: rho; PRK09376 265669008219 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 265669008220 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 265669008221 RNA binding site [nucleotide binding]; other site 265669008222 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 265669008223 multimer interface [polypeptide binding]; other site 265669008224 Walker A motif; other site 265669008225 ATP binding site [chemical binding]; other site 265669008226 Walker B motif; other site 265669008227 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 265669008228 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 265669008229 hinge; other site 265669008230 active site 265669008231 Predicted integral membrane protein [Function unknown]; Region: COG0392 265669008232 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 265669008233 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 265669008234 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 265669008235 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 265669008236 putative ADP-binding pocket [chemical binding]; other site 265669008237 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 265669008238 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 265669008239 intersubunit interface [polypeptide binding]; other site 265669008240 active site 265669008241 zinc binding site [ion binding]; other site 265669008242 Na+ binding site [ion binding]; other site 265669008243 putative lipid kinase; Reviewed; Region: PRK13055 265669008244 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 265669008245 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 265669008246 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 265669008247 substrate binding site [chemical binding]; other site 265669008248 SH3-like domain; Region: SH3_8; pfam13457 265669008249 SH3-like domain; Region: SH3_8; pfam13457 265669008250 SH3-like domain; Region: SH3_8; pfam13457 265669008251 CTP synthetase; Validated; Region: pyrG; PRK05380 265669008252 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 265669008253 Catalytic site [active] 265669008254 active site 265669008255 UTP binding site [chemical binding]; other site 265669008256 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 265669008257 active site 265669008258 putative oxyanion hole; other site 265669008259 catalytic triad [active] 265669008260 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 265669008261 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 265669008262 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 265669008263 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 265669008264 active site 265669008265 HIGH motif; other site 265669008266 KMSK motif region; other site 265669008267 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 265669008268 tRNA binding surface [nucleotide binding]; other site 265669008269 anticodon binding site; other site 265669008270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 265669008271 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 265669008272 Peptidase family M50; Region: Peptidase_M50; pfam02163 265669008273 active site 265669008274 putative substrate binding region [chemical binding]; other site 265669008275 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 265669008276 active site 1 [active] 265669008277 dimer interface [polypeptide binding]; other site 265669008278 hexamer interface [polypeptide binding]; other site 265669008279 active site 2 [active] 265669008280 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 265669008281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 265669008282 Zn2+ binding site [ion binding]; other site 265669008283 Mg2+ binding site [ion binding]; other site 265669008284 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 265669008285 conserved hypothetical protein TIGR01655; Region: yxeA_fam 265669008286 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 265669008287 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 265669008288 peptide binding site [polypeptide binding]; other site 265669008289 Predicted integral membrane protein [Function unknown]; Region: COG5658 265669008290 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 265669008291 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 265669008292 catalytic triad [active] 265669008293 metal binding site [ion binding]; metal-binding site 265669008294 conserved cis-peptide bond; other site 265669008295 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 265669008296 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 265669008297 folate binding site [chemical binding]; other site 265669008298 NADP+ binding site [chemical binding]; other site 265669008299 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 265669008300 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 265669008301 putative NAD(P) binding site [chemical binding]; other site 265669008302 dimer interface [polypeptide binding]; other site 265669008303 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 265669008304 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 265669008305 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 265669008306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669008307 active site 265669008308 motif I; other site 265669008309 motif II; other site 265669008310 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 265669008311 Uncharacterized conserved protein [Function unknown]; Region: COG1359 265669008312 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 265669008313 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 265669008314 Walker A/P-loop; other site 265669008315 ATP binding site [chemical binding]; other site 265669008316 Q-loop/lid; other site 265669008317 ABC transporter signature motif; other site 265669008318 Walker B; other site 265669008319 D-loop; other site 265669008320 H-loop/switch region; other site 265669008321 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 265669008322 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 265669008323 FtsX-like permease family; Region: FtsX; pfam02687 265669008324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 265669008325 dimerization interface [polypeptide binding]; other site 265669008326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 265669008327 dimer interface [polypeptide binding]; other site 265669008328 phosphorylation site [posttranslational modification] 265669008329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669008330 ATP binding site [chemical binding]; other site 265669008331 Mg2+ binding site [ion binding]; other site 265669008332 G-X-G motif; other site 265669008333 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 265669008334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669008335 active site 265669008336 phosphorylation site [posttranslational modification] 265669008337 intermolecular recognition site; other site 265669008338 dimerization interface [polypeptide binding]; other site 265669008339 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 265669008340 DNA binding site [nucleotide binding] 265669008341 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 265669008342 Uncharacterized conserved protein [Function unknown]; Region: COG2427 265669008343 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 265669008344 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 265669008345 catalytic loop [active] 265669008346 iron binding site [ion binding]; other site 265669008347 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 265669008348 4Fe-4S binding domain; Region: Fer4; pfam00037 265669008349 4Fe-4S binding domain; Region: Fer4; pfam00037 265669008350 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 265669008351 [4Fe-4S] binding site [ion binding]; other site 265669008352 molybdopterin cofactor binding site; other site 265669008353 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 265669008354 molybdopterin cofactor binding site; other site 265669008355 Uncharacterized conserved protein [Function unknown]; Region: COG1912 265669008356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669008357 Major Facilitator Superfamily; Region: MFS_1; pfam07690 265669008358 putative substrate translocation pore; other site 265669008359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 265669008360 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 265669008361 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 265669008362 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 265669008363 Walker A motif; other site 265669008364 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 265669008365 SH3-like domain; Region: SH3_8; pfam13457 265669008366 SH3-like domain; Region: SH3_8; pfam13457 265669008367 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 265669008368 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 265669008369 active site 265669008370 catalytic tetrad [active] 265669008371 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 265669008372 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 265669008373 DNA binding residues [nucleotide binding] 265669008374 putative dimer interface [polypeptide binding]; other site 265669008375 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 265669008376 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 265669008377 23S rRNA interface [nucleotide binding]; other site 265669008378 L3 interface [polypeptide binding]; other site 265669008379 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 265669008380 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 265669008381 dimerization interface 3.5A [polypeptide binding]; other site 265669008382 active site 265669008383 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 265669008384 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 265669008385 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 265669008386 Walker A/P-loop; other site 265669008387 ATP binding site [chemical binding]; other site 265669008388 Q-loop/lid; other site 265669008389 ABC transporter signature motif; other site 265669008390 Walker B; other site 265669008391 D-loop; other site 265669008392 H-loop/switch region; other site 265669008393 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 265669008394 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 265669008395 Walker A/P-loop; other site 265669008396 ATP binding site [chemical binding]; other site 265669008397 Q-loop/lid; other site 265669008398 ABC transporter signature motif; other site 265669008399 Walker B; other site 265669008400 D-loop; other site 265669008401 H-loop/switch region; other site 265669008402 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 265669008403 MgtC family; Region: MgtC; pfam02308 265669008404 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 265669008405 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 265669008406 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 265669008407 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 265669008408 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 265669008409 alphaNTD - beta interaction site [polypeptide binding]; other site 265669008410 alphaNTD homodimer interface [polypeptide binding]; other site 265669008411 alphaNTD - beta' interaction site [polypeptide binding]; other site 265669008412 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 265669008413 30S ribosomal protein S11; Validated; Region: PRK05309 265669008414 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 265669008415 30S ribosomal protein S13; Region: bact_S13; TIGR03631 265669008416 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 265669008417 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 265669008418 rRNA binding site [nucleotide binding]; other site 265669008419 predicted 30S ribosome binding site; other site 265669008420 adenylate kinase; Reviewed; Region: adk; PRK00279 265669008421 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 265669008422 AMP-binding site [chemical binding]; other site 265669008423 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 265669008424 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 265669008425 SecY translocase; Region: SecY; pfam00344 265669008426 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 265669008427 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 265669008428 23S rRNA binding site [nucleotide binding]; other site 265669008429 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 265669008430 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 265669008431 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 265669008432 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 265669008433 5S rRNA interface [nucleotide binding]; other site 265669008434 L27 interface [polypeptide binding]; other site 265669008435 23S rRNA interface [nucleotide binding]; other site 265669008436 L5 interface [polypeptide binding]; other site 265669008437 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 265669008438 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 265669008439 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 265669008440 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 265669008441 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 265669008442 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 265669008443 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 265669008444 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 265669008445 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 265669008446 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 265669008447 RNA binding site [nucleotide binding]; other site 265669008448 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 265669008449 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 265669008450 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 265669008451 23S rRNA interface [nucleotide binding]; other site 265669008452 putative translocon interaction site; other site 265669008453 signal recognition particle (SRP54) interaction site; other site 265669008454 L23 interface [polypeptide binding]; other site 265669008455 trigger factor interaction site; other site 265669008456 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 265669008457 23S rRNA interface [nucleotide binding]; other site 265669008458 5S rRNA interface [nucleotide binding]; other site 265669008459 putative antibiotic binding site [chemical binding]; other site 265669008460 L25 interface [polypeptide binding]; other site 265669008461 L27 interface [polypeptide binding]; other site 265669008462 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 265669008463 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 265669008464 G-X-X-G motif; other site 265669008465 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 265669008466 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 265669008467 putative translocon binding site; other site 265669008468 protein-rRNA interface [nucleotide binding]; other site 265669008469 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 265669008470 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 265669008471 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 265669008472 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 265669008473 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 265669008474 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 265669008475 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 265669008476 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 265669008477 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 265669008478 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 265669008479 UbiA prenyltransferase family; Region: UbiA; pfam01040 265669008480 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 265669008481 ApbE family; Region: ApbE; pfam02424 265669008482 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 265669008483 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 265669008484 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 265669008485 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 265669008486 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 265669008487 Predicted membrane protein [Function unknown]; Region: COG2259 265669008488 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 265669008489 trimer interface [polypeptide binding]; other site 265669008490 Predicted membrane protein [Function unknown]; Region: COG4769 265669008491 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 265669008492 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 265669008493 substrate binding pocket [chemical binding]; other site 265669008494 chain length determination region; other site 265669008495 substrate-Mg2+ binding site; other site 265669008496 catalytic residues [active] 265669008497 aspartate-rich region 1; other site 265669008498 active site lid residues [active] 265669008499 aspartate-rich region 2; other site 265669008500 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 265669008501 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 265669008502 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 265669008503 active site 265669008504 metal binding site [ion binding]; metal-binding site 265669008505 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 265669008506 hypothetical protein; Provisional; Region: PRK02947 265669008507 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 265669008508 putative active site [active] 265669008509 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 265669008510 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 265669008511 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 265669008512 active site 265669008513 substrate binding pocket [chemical binding]; other site 265669008514 homodimer interaction site [polypeptide binding]; other site 265669008515 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 265669008516 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 265669008517 active site 265669008518 P-loop; other site 265669008519 phosphorylation site [posttranslational modification] 265669008520 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669008521 active site 265669008522 phosphorylation site [posttranslational modification] 265669008523 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 265669008524 Mga helix-turn-helix domain; Region: Mga; pfam05043 265669008525 PRD domain; Region: PRD; pfam00874 265669008526 PRD domain; Region: PRD; pfam00874 265669008527 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 265669008528 active site 265669008529 P-loop; other site 265669008530 phosphorylation site [posttranslational modification] 265669008531 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669008532 active site 265669008533 phosphorylation site [posttranslational modification] 265669008534 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 265669008535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669008536 Walker A/P-loop; other site 265669008537 ATP binding site [chemical binding]; other site 265669008538 Q-loop/lid; other site 265669008539 ABC transporter signature motif; other site 265669008540 Walker B; other site 265669008541 D-loop; other site 265669008542 H-loop/switch region; other site 265669008543 elongation factor Tu; Reviewed; Region: PRK00049 265669008544 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 265669008545 G1 box; other site 265669008546 GEF interaction site [polypeptide binding]; other site 265669008547 GTP/Mg2+ binding site [chemical binding]; other site 265669008548 Switch I region; other site 265669008549 G2 box; other site 265669008550 G3 box; other site 265669008551 Switch II region; other site 265669008552 G4 box; other site 265669008553 G5 box; other site 265669008554 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 265669008555 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 265669008556 Antibiotic Binding Site [chemical binding]; other site 265669008557 elongation factor G; Reviewed; Region: PRK00007 265669008558 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 265669008559 G1 box; other site 265669008560 putative GEF interaction site [polypeptide binding]; other site 265669008561 GTP/Mg2+ binding site [chemical binding]; other site 265669008562 Switch I region; other site 265669008563 G2 box; other site 265669008564 G3 box; other site 265669008565 Switch II region; other site 265669008566 G4 box; other site 265669008567 G5 box; other site 265669008568 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 265669008569 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 265669008570 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 265669008571 30S ribosomal protein S7; Validated; Region: PRK05302 265669008572 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 265669008573 S17 interaction site [polypeptide binding]; other site 265669008574 S8 interaction site; other site 265669008575 16S rRNA interaction site [nucleotide binding]; other site 265669008576 streptomycin interaction site [chemical binding]; other site 265669008577 23S rRNA interaction site [nucleotide binding]; other site 265669008578 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 265669008579 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 265669008580 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 265669008581 Zn2+ binding site [ion binding]; other site 265669008582 Mg2+ binding site [ion binding]; other site 265669008583 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 265669008584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669008585 Coenzyme A binding pocket [chemical binding]; other site 265669008586 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 265669008587 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669008588 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669008589 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 265669008590 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 265669008591 substrate binding site [chemical binding]; other site 265669008592 hexamer interface [polypeptide binding]; other site 265669008593 metal binding site [ion binding]; metal-binding site 265669008594 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 265669008595 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 265669008596 TPP-binding site [chemical binding]; other site 265669008597 dimer interface [polypeptide binding]; other site 265669008598 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 265669008599 PYR/PP interface [polypeptide binding]; other site 265669008600 dimer interface [polypeptide binding]; other site 265669008601 TPP binding site [chemical binding]; other site 265669008602 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 265669008603 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 265669008604 substrate binding site [chemical binding]; other site 265669008605 hexamer interface [polypeptide binding]; other site 265669008606 metal binding site [ion binding]; metal-binding site 265669008607 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 265669008608 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 265669008609 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 265669008610 putative NAD(P) binding site [chemical binding]; other site 265669008611 catalytic Zn binding site [ion binding]; other site 265669008612 structural Zn binding site [ion binding]; other site 265669008613 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 265669008614 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 265669008615 putative NAD(P) binding site [chemical binding]; other site 265669008616 catalytic Zn binding site [ion binding]; other site 265669008617 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 265669008618 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 265669008619 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 265669008620 active site 265669008621 P-loop; other site 265669008622 phosphorylation site [posttranslational modification] 265669008623 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669008624 active site 265669008625 phosphorylation site [posttranslational modification] 265669008626 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 265669008627 PRD domain; Region: PRD; pfam00874 265669008628 PRD domain; Region: PRD; pfam00874 265669008629 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 265669008630 active site 265669008631 P-loop; other site 265669008632 phosphorylation site [posttranslational modification] 265669008633 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 265669008634 active site 265669008635 phosphorylation site [posttranslational modification] 265669008636 Predicted membrane protein [Function unknown]; Region: COG4905 265669008637 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 265669008638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 265669008639 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 265669008640 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 265669008641 active site 265669008642 Helix-turn-helix domain; Region: HTH_18; pfam12833 265669008643 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 265669008644 Ligand Binding Site [chemical binding]; other site 265669008645 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 265669008646 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 265669008647 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 265669008648 active site 265669008649 DNA binding site [nucleotide binding] 265669008650 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 265669008651 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 265669008652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 265669008653 active site 265669008654 phosphorylation site [posttranslational modification] 265669008655 intermolecular recognition site; other site 265669008656 dimerization interface [polypeptide binding]; other site 265669008657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 265669008658 DNA binding site [nucleotide binding] 265669008659 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 265669008660 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 265669008661 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 265669008662 Ligand Binding Site [chemical binding]; other site 265669008663 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 265669008664 GAF domain; Region: GAF_3; pfam13492 265669008665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 265669008666 dimer interface [polypeptide binding]; other site 265669008667 phosphorylation site [posttranslational modification] 265669008668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 265669008669 ATP binding site [chemical binding]; other site 265669008670 Mg2+ binding site [ion binding]; other site 265669008671 G-X-G motif; other site 265669008672 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 265669008673 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 265669008674 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 265669008675 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 265669008676 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 265669008677 active site 265669008678 P-loop; other site 265669008679 phosphorylation site [posttranslational modification] 265669008680 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 265669008681 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 265669008682 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 265669008683 methionine cluster; other site 265669008684 active site 265669008685 phosphorylation site [posttranslational modification] 265669008686 metal binding site [ion binding]; metal-binding site 265669008687 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 265669008688 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 265669008689 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 265669008690 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 265669008691 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 265669008692 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 265669008693 Soluble P-type ATPase [General function prediction only]; Region: COG4087 265669008694 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 265669008695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 265669008696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 265669008697 autolysin; Reviewed; Region: PRK06347 265669008698 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 265669008699 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 265669008700 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 265669008701 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 265669008702 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 265669008703 Protein of unknown function (DUF970); Region: DUF970; pfam06153 265669008704 thymidylate kinase; Validated; Region: tmk; PRK00698 265669008705 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 265669008706 TMP-binding site; other site 265669008707 ATP-binding site [chemical binding]; other site 265669008708 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 265669008709 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 265669008710 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 265669008711 catalytic residue [active] 265669008712 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 265669008713 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 265669008714 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 265669008715 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 265669008716 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 265669008717 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 265669008718 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 265669008719 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 265669008720 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 265669008721 putative active site [active] 265669008722 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 265669008723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669008724 active site 265669008725 motif I; other site 265669008726 motif II; other site 265669008727 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 265669008728 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 265669008729 nudix motif; other site 265669008730 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 265669008731 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 265669008732 active site 265669008733 catalytic tetrad [active] 265669008734 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 265669008735 recombination protein RecR; Reviewed; Region: recR; PRK00076 265669008736 RecR protein; Region: RecR; pfam02132 265669008737 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 265669008738 putative active site [active] 265669008739 putative metal-binding site [ion binding]; other site 265669008740 tetramer interface [polypeptide binding]; other site 265669008741 hypothetical protein; Validated; Region: PRK00153 265669008742 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 265669008743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 265669008744 Walker A motif; other site 265669008745 ATP binding site [chemical binding]; other site 265669008746 Walker B motif; other site 265669008747 arginine finger; other site 265669008748 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 265669008749 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 265669008750 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 265669008751 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 265669008752 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 265669008753 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 265669008754 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 265669008755 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 265669008756 N- and C-terminal domain interface [polypeptide binding]; other site 265669008757 active site 265669008758 catalytic site [active] 265669008759 metal binding site [ion binding]; metal-binding site 265669008760 carbohydrate binding site [chemical binding]; other site 265669008761 ATP binding site [chemical binding]; other site 265669008762 SH3-like domain; Region: SH3_8; pfam13457 265669008763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 265669008764 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 265669008765 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 265669008766 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 265669008767 Walker A/P-loop; other site 265669008768 ATP binding site [chemical binding]; other site 265669008769 Q-loop/lid; other site 265669008770 ABC transporter signature motif; other site 265669008771 Walker B; other site 265669008772 D-loop; other site 265669008773 H-loop/switch region; other site 265669008774 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 265669008775 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 265669008776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669008777 Walker A/P-loop; other site 265669008778 ATP binding site [chemical binding]; other site 265669008779 Q-loop/lid; other site 265669008780 ABC transporter signature motif; other site 265669008781 Walker B; other site 265669008782 D-loop; other site 265669008783 H-loop/switch region; other site 265669008784 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 265669008785 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 265669008786 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 265669008787 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 265669008788 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 265669008789 nucleoside/Zn binding site; other site 265669008790 dimer interface [polypeptide binding]; other site 265669008791 catalytic motif [active] 265669008792 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 265669008793 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 265669008794 active site 265669008795 acyl-activating enzyme (AAE) consensus motif; other site 265669008796 putative CoA binding site [chemical binding]; other site 265669008797 AMP binding site [chemical binding]; other site 265669008798 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 265669008799 substrate binding site [chemical binding]; other site 265669008800 activation loop (A-loop); other site 265669008801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 265669008802 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 265669008803 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 265669008804 active site 265669008805 trimer interface [polypeptide binding]; other site 265669008806 allosteric site; other site 265669008807 active site lid [active] 265669008808 hexamer (dimer of trimers) interface [polypeptide binding]; other site 265669008809 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 265669008810 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 265669008811 DNA binding residues [nucleotide binding] 265669008812 drug binding residues [chemical binding]; other site 265669008813 dimer interface [polypeptide binding]; other site 265669008814 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 265669008815 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 265669008816 Coenzyme A binding pocket [chemical binding]; other site 265669008817 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 265669008818 dimer interface [polypeptide binding]; other site 265669008819 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 265669008820 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 265669008821 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 265669008822 MarR family; Region: MarR; pfam01047 265669008823 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 265669008824 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 265669008825 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 265669008826 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 265669008827 DNA binding residues [nucleotide binding] 265669008828 putative dimer interface [polypeptide binding]; other site 265669008829 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 265669008830 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 265669008831 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669008832 active site 265669008833 motif I; other site 265669008834 motif II; other site 265669008835 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 265669008836 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 265669008837 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 265669008838 putative active site [active] 265669008839 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 265669008840 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669008841 active site 265669008842 phosphorylation site [posttranslational modification] 265669008843 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 265669008844 active site 265669008845 P-loop; other site 265669008846 phosphorylation site [posttranslational modification] 265669008847 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 265669008848 alpha-mannosidase; Provisional; Region: PRK09819 265669008849 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 265669008850 active site 265669008851 metal binding site [ion binding]; metal-binding site 265669008852 catalytic site [active] 265669008853 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 265669008854 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 265669008855 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 265669008856 active site 265669008857 homodimer interface [polypeptide binding]; other site 265669008858 catalytic site [active] 265669008859 glycerate kinase; Region: TIGR00045 265669008860 Transcriptional regulators [Transcription]; Region: PurR; COG1609 265669008861 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 265669008862 DNA binding site [nucleotide binding] 265669008863 domain linker motif; other site 265669008864 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 265669008865 putative dimerization interface [polypeptide binding]; other site 265669008866 putative ligand binding site [chemical binding]; other site 265669008867 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 265669008868 Domain of unknown function DUF21; Region: DUF21; pfam01595 265669008869 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 265669008870 Transporter associated domain; Region: CorC_HlyC; pfam03471 265669008871 NAD-dependent deacetylase; Provisional; Region: PRK00481 265669008872 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 265669008873 NAD+ binding site [chemical binding]; other site 265669008874 substrate binding site [chemical binding]; other site 265669008875 putative Zn binding site [ion binding]; other site 265669008876 Pathogenicity locus; Region: Cdd1; pfam11731 265669008877 drug efflux system protein MdtG; Provisional; Region: PRK09874 265669008878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669008879 putative substrate translocation pore; other site 265669008880 Src Homology 3 domain superfamily; Region: SH3; cl17036 265669008881 Variant SH3 domain; Region: SH3_2; pfam07653 265669008882 peptide ligand binding site [polypeptide binding]; other site 265669008883 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 265669008884 active site 265669008885 intersubunit interactions; other site 265669008886 catalytic residue [active] 265669008887 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 265669008888 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 265669008889 ligand binding site [chemical binding]; other site 265669008890 flexible hinge region; other site 265669008891 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 265669008892 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 265669008893 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 265669008894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669008895 Walker A/P-loop; other site 265669008896 ATP binding site [chemical binding]; other site 265669008897 Q-loop/lid; other site 265669008898 ABC transporter signature motif; other site 265669008899 Walker B; other site 265669008900 D-loop; other site 265669008901 H-loop/switch region; other site 265669008902 TfoX C-terminal domain; Region: TfoX_C; pfam04994 265669008903 seryl-tRNA synthetase; Provisional; Region: PRK05431 265669008904 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 265669008905 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 265669008906 dimer interface [polypeptide binding]; other site 265669008907 active site 265669008908 motif 1; other site 265669008909 motif 2; other site 265669008910 motif 3; other site 265669008911 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 265669008912 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 265669008913 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 265669008914 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 265669008915 glutamine binding [chemical binding]; other site 265669008916 catalytic triad [active] 265669008917 aminodeoxychorismate synthase; Provisional; Region: PRK07508 265669008918 chorismate binding enzyme; Region: Chorismate_bind; cl10555 265669008919 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 265669008920 substrate-cofactor binding pocket; other site 265669008921 homodimer interface [polypeptide binding]; other site 265669008922 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 265669008923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 265669008924 catalytic residue [active] 265669008925 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 265669008926 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 265669008927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669008928 Walker A/P-loop; other site 265669008929 ATP binding site [chemical binding]; other site 265669008930 Q-loop/lid; other site 265669008931 ABC transporter signature motif; other site 265669008932 Walker B; other site 265669008933 D-loop; other site 265669008934 H-loop/switch region; other site 265669008935 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 265669008936 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 265669008937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 265669008938 Walker A/P-loop; other site 265669008939 ATP binding site [chemical binding]; other site 265669008940 Q-loop/lid; other site 265669008941 ABC transporter signature motif; other site 265669008942 Walker B; other site 265669008943 D-loop; other site 265669008944 H-loop/switch region; other site 265669008945 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 265669008946 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 265669008947 Ligand binding site; other site 265669008948 Putative Catalytic site; other site 265669008949 DXD motif; other site 265669008950 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 265669008951 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 265669008952 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 265669008953 Predicted acyl esterases [General function prediction only]; Region: COG2936 265669008954 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 265669008955 DNA topoisomerase III; Provisional; Region: PRK07726 265669008956 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 265669008957 active site 265669008958 putative interdomain interaction site [polypeptide binding]; other site 265669008959 putative metal-binding site [ion binding]; other site 265669008960 putative nucleotide binding site [chemical binding]; other site 265669008961 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 265669008962 domain I; other site 265669008963 DNA binding groove [nucleotide binding] 265669008964 phosphate binding site [ion binding]; other site 265669008965 domain II; other site 265669008966 domain III; other site 265669008967 nucleotide binding site [chemical binding]; other site 265669008968 catalytic site [active] 265669008969 domain IV; other site 265669008970 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 265669008971 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 265669008972 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 265669008973 ATP binding site [chemical binding]; other site 265669008974 putative Mg++ binding site [ion binding]; other site 265669008975 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 265669008976 nucleotide binding region [chemical binding]; other site 265669008977 ATP-binding site [chemical binding]; other site 265669008978 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 265669008979 HRDC domain; Region: HRDC; pfam00570 265669008980 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 265669008981 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 265669008982 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 265669008983 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 265669008984 active site 265669008985 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 265669008986 putative ADP-ribose binding site [chemical binding]; other site 265669008987 putative active site [active] 265669008988 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 265669008989 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 265669008990 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 265669008991 ABC transporter; Region: ABC_tran_2; pfam12848 265669008992 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 265669008993 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 265669008994 beta-galactosidase; Region: BGL; TIGR03356 265669008995 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 265669008996 active site 265669008997 P-loop; other site 265669008998 phosphorylation site [posttranslational modification] 265669008999 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 265669009000 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 265669009001 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 265669009002 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 265669009003 nucleotide binding site [chemical binding]; other site 265669009004 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 265669009005 methionine cluster; other site 265669009006 active site 265669009007 phosphorylation site [posttranslational modification] 265669009008 metal binding site [ion binding]; metal-binding site 265669009009 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 265669009010 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 265669009011 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 265669009012 putative active site [active] 265669009013 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 265669009014 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 265669009015 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 265669009016 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 265669009017 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 265669009018 Walker A/P-loop; other site 265669009019 ATP binding site [chemical binding]; other site 265669009020 Q-loop/lid; other site 265669009021 ABC transporter signature motif; other site 265669009022 Walker B; other site 265669009023 D-loop; other site 265669009024 H-loop/switch region; other site 265669009025 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 265669009026 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 265669009027 ATP-grasp domain; Region: ATP-grasp_4; cl17255 265669009028 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 265669009029 beta-galactosidase; Region: BGL; TIGR03356 265669009030 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 265669009031 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 265669009032 active site turn [active] 265669009033 phosphorylation site [posttranslational modification] 265669009034 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 265669009035 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 265669009036 HPr interaction site; other site 265669009037 glycerol kinase (GK) interaction site [polypeptide binding]; other site 265669009038 active site 265669009039 phosphorylation site [posttranslational modification] 265669009040 transcriptional antiterminator BglG; Provisional; Region: PRK09772 265669009041 CAT RNA binding domain; Region: CAT_RBD; smart01061 265669009042 PRD domain; Region: PRD; pfam00874 265669009043 PRD domain; Region: PRD; pfam00874 265669009044 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 265669009045 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 265669009046 Walker A/P-loop; other site 265669009047 ATP binding site [chemical binding]; other site 265669009048 Q-loop/lid; other site 265669009049 ABC transporter signature motif; other site 265669009050 Walker B; other site 265669009051 D-loop; other site 265669009052 H-loop/switch region; other site 265669009053 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 265669009054 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 265669009055 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 265669009056 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 265669009057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669009058 putative substrate translocation pore; other site 265669009059 GTP-binding protein YchF; Reviewed; Region: PRK09601 265669009060 YchF GTPase; Region: YchF; cd01900 265669009061 G1 box; other site 265669009062 GTP/Mg2+ binding site [chemical binding]; other site 265669009063 Switch I region; other site 265669009064 G2 box; other site 265669009065 Switch II region; other site 265669009066 G3 box; other site 265669009067 G4 box; other site 265669009068 G5 box; other site 265669009069 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 265669009070 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 265669009071 methionine cluster; other site 265669009072 active site 265669009073 phosphorylation site [posttranslational modification] 265669009074 metal binding site [ion binding]; metal-binding site 265669009075 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 265669009076 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 265669009077 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 265669009078 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 265669009079 active site 265669009080 P-loop; other site 265669009081 phosphorylation site [posttranslational modification] 265669009082 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 265669009083 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 265669009084 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 265669009085 HTH domain; Region: HTH_11; pfam08279 265669009086 Mga helix-turn-helix domain; Region: Mga; pfam05043 265669009087 PRD domain; Region: PRD; pfam00874 265669009088 PRD domain; Region: PRD; pfam00874 265669009089 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 265669009090 active site 265669009091 P-loop; other site 265669009092 phosphorylation site [posttranslational modification] 265669009093 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669009094 active site 265669009095 phosphorylation site [posttranslational modification] 265669009096 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 265669009097 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 265669009098 tetramer interface [polypeptide binding]; other site 265669009099 heme binding pocket [chemical binding]; other site 265669009100 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 265669009101 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 265669009102 ParB-like nuclease domain; Region: ParB; smart00470 265669009103 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 265669009104 salt bridge; other site 265669009105 non-specific DNA binding site [nucleotide binding]; other site 265669009106 sequence-specific DNA binding site [nucleotide binding]; other site 265669009107 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 265669009108 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 265669009109 P-loop; other site 265669009110 Magnesium ion binding site [ion binding]; other site 265669009111 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 265669009112 Magnesium ion binding site [ion binding]; other site 265669009113 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 265669009114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669009115 non-specific DNA binding site [nucleotide binding]; other site 265669009116 salt bridge; other site 265669009117 sequence-specific DNA binding site [nucleotide binding]; other site 265669009118 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 265669009119 ParB-like nuclease domain; Region: ParBc; pfam02195 265669009120 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 265669009121 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 265669009122 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 265669009123 putative active site [active] 265669009124 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 265669009125 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 265669009126 nucleotide binding site [chemical binding]; other site 265669009127 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 265669009128 active site 265669009129 phosphorylation site [posttranslational modification] 265669009130 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 265669009131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669009132 motif II; other site 265669009133 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 265669009134 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 265669009135 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 265669009136 active site 265669009137 P-loop; other site 265669009138 phosphorylation site [posttranslational modification] 265669009139 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 265669009140 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 265669009141 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 265669009142 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 265669009143 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 265669009144 putative active site cavity [active] 265669009145 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 265669009146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 265669009147 S-adenosylmethionine binding site [chemical binding]; other site 265669009148 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 265669009149 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 265669009150 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 265669009151 Abi-like protein; Region: Abi_2; pfam07751 265669009152 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 265669009153 non-specific DNA binding site [nucleotide binding]; other site 265669009154 salt bridge; other site 265669009155 sequence-specific DNA binding site [nucleotide binding]; other site 265669009156 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 265669009157 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 265669009158 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 265669009159 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 265669009160 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 265669009161 trmE is a tRNA modification GTPase; Region: trmE; cd04164 265669009162 G1 box; other site 265669009163 GTP/Mg2+ binding site [chemical binding]; other site 265669009164 Switch I region; other site 265669009165 G2 box; other site 265669009166 Switch II region; other site 265669009167 G3 box; other site 265669009168 G4 box; other site 265669009169 G5 box; other site 265669009170 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 265669009171 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 265669009172 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 265669009173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 265669009174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 265669009175 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 265669009176 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 265669009177 NADP binding site [chemical binding]; other site 265669009178 homodimer interface [polypeptide binding]; other site 265669009179 active site 265669009180 substrate binding site [chemical binding]; other site 265669009181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669009182 D-galactonate transporter; Region: 2A0114; TIGR00893 265669009183 putative substrate translocation pore; other site 265669009184 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 265669009185 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 265669009186 metal binding site [ion binding]; metal-binding site 265669009187 dimer interface [polypeptide binding]; other site 265669009188 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 265669009189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 265669009190 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 265669009191 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 265669009192 metal binding site [ion binding]; metal-binding site 265669009193 dimer interface [polypeptide binding]; other site 265669009194 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 265669009195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 265669009196 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 265669009197 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 265669009198 Leucine-rich repeats; other site 265669009199 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669009200 Substrate binding site [chemical binding]; other site 265669009201 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 265669009202 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669009203 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669009204 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669009205 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669009206 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 265669009207 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 265669009208 Uncharacterized conserved protein [Function unknown]; Region: COG4198 265669009209 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 265669009210 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 265669009211 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 265669009212 putative ligand binding site [chemical binding]; other site 265669009213 putative NAD binding site [chemical binding]; other site 265669009214 putative catalytic site [active] 265669009215 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 265669009216 L-serine binding site [chemical binding]; other site 265669009217 ACT domain interface; other site 265669009218 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 265669009219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 265669009220 catalytic residue [active] 265669009221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669009222 Major Facilitator Superfamily; Region: MFS_1; pfam07690 265669009223 putative substrate translocation pore; other site 265669009224 Transcriptional regulators [Transcription]; Region: MarR; COG1846 265669009225 MarR family; Region: MarR_2; pfam12802 265669009226 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 265669009227 dimer interface [polypeptide binding]; other site 265669009228 FMN binding site [chemical binding]; other site 265669009229 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 265669009230 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 265669009231 catalytic residues [active] 265669009232 beta-phosphoglucomutase; Region: bPGM; TIGR01990 265669009233 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 265669009234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 265669009235 motif II; other site 265669009236 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 265669009237 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 265669009238 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 265669009239 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 265669009240 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 265669009241 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 265669009242 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 265669009243 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 265669009244 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 265669009245 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 265669009246 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 265669009247 putative NAD(P) binding site [chemical binding]; other site 265669009248 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 265669009249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669009250 dimer interface [polypeptide binding]; other site 265669009251 conserved gate region; other site 265669009252 putative PBP binding loops; other site 265669009253 ABC-ATPase subunit interface; other site 265669009254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 265669009255 dimer interface [polypeptide binding]; other site 265669009256 conserved gate region; other site 265669009257 putative PBP binding loops; other site 265669009258 ABC-ATPase subunit interface; other site 265669009259 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 265669009260 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 265669009261 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 265669009262 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 265669009263 active site 265669009264 homodimer interface [polypeptide binding]; other site 265669009265 catalytic site [active] 265669009266 Transcriptional regulators [Transcription]; Region: PurR; COG1609 265669009267 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 265669009268 DNA binding site [nucleotide binding] 265669009269 domain linker motif; other site 265669009270 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 265669009271 putative dimerization interface [polypeptide binding]; other site 265669009272 putative ligand binding site [chemical binding]; other site 265669009273 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 265669009274 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 265669009275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 265669009276 Coenzyme A binding pocket [chemical binding]; other site 265669009277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669009278 Major Facilitator Superfamily; Region: MFS_1; pfam07690 265669009279 putative substrate translocation pore; other site 265669009280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669009281 Domain of unknown function (DUF718); Region: DUF718; cl01281 265669009282 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 265669009283 intersubunit interface [polypeptide binding]; other site 265669009284 active site 265669009285 Zn2+ binding site [ion binding]; other site 265669009286 L-rhamnose isomerase; Provisional; Region: PRK01076 265669009287 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 265669009288 N- and C-terminal domain interface [polypeptide binding]; other site 265669009289 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 265669009290 active site 265669009291 putative catalytic site [active] 265669009292 metal binding site [ion binding]; metal-binding site 265669009293 ATP binding site [chemical binding]; other site 265669009294 carbohydrate binding site [chemical binding]; other site 265669009295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 265669009296 putative substrate translocation pore; other site 265669009297 Major Facilitator Superfamily; Region: MFS_1; pfam07690 265669009298 Cupin domain; Region: Cupin_2; pfam07883 265669009299 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 265669009300 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 265669009301 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 265669009302 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 265669009303 G-X-X-G motif; other site 265669009304 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 265669009305 RxxxH motif; other site 265669009306 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 265669009307 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 265669009308 ribonuclease P; Reviewed; Region: rnpA; PRK00499 265669009309 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399