-- dump date 20140619_134002 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1230340000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1230340000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1230340000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340000004 Walker A motif; other site 1230340000005 ATP binding site [chemical binding]; other site 1230340000006 Walker B motif; other site 1230340000007 arginine finger; other site 1230340000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1230340000009 DnaA box-binding interface [nucleotide binding]; other site 1230340000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1230340000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1230340000012 putative DNA binding surface [nucleotide binding]; other site 1230340000013 dimer interface [polypeptide binding]; other site 1230340000014 beta-clamp/clamp loader binding surface; other site 1230340000015 beta-clamp/translesion DNA polymerase binding surface; other site 1230340000016 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1230340000017 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1230340000018 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 1230340000019 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 1230340000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1230340000021 Q-loop/lid; other site 1230340000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340000023 ABC transporter signature motif; other site 1230340000024 Walker B; other site 1230340000025 D-loop; other site 1230340000026 H-loop/switch region; other site 1230340000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1230340000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340000029 Mg2+ binding site [ion binding]; other site 1230340000030 G-X-G motif; other site 1230340000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1230340000032 anchoring element; other site 1230340000033 dimer interface [polypeptide binding]; other site 1230340000034 ATP binding site [chemical binding]; other site 1230340000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1230340000036 active site 1230340000037 putative metal-binding site [ion binding]; other site 1230340000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1230340000039 DNA gyrase subunit A; Validated; Region: PRK05560 1230340000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1230340000041 CAP-like domain; other site 1230340000042 active site 1230340000043 primary dimer interface [polypeptide binding]; other site 1230340000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1230340000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1230340000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1230340000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1230340000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1230340000049 cardiolipin synthetase; Reviewed; Region: PRK12452 1230340000050 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1230340000051 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1230340000052 putative active site [active] 1230340000053 catalytic site [active] 1230340000054 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1230340000055 putative active site [active] 1230340000056 catalytic site [active] 1230340000057 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1230340000058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340000059 Coenzyme A binding pocket [chemical binding]; other site 1230340000060 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1230340000061 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1230340000062 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1230340000063 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1230340000064 diphosphomevalonate decarboxylase; Region: PLN02407 1230340000065 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1230340000066 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1230340000067 SH3-like domain; Region: SH3_8; pfam13457 1230340000068 SH3-like domain; Region: SH3_8; pfam13457 1230340000069 SH3-like domain; Region: SH3_8; pfam13457 1230340000070 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1230340000071 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1230340000072 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1230340000073 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1230340000074 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1230340000075 D-pathway; other site 1230340000076 Putative ubiquinol binding site [chemical binding]; other site 1230340000077 Low-spin heme (heme b) binding site [chemical binding]; other site 1230340000078 Putative water exit pathway; other site 1230340000079 Binuclear center (heme o3/CuB) [ion binding]; other site 1230340000080 K-pathway; other site 1230340000081 Putative proton exit pathway; other site 1230340000082 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1230340000083 Subunit I/III interface [polypeptide binding]; other site 1230340000084 Subunit III/IV interface [polypeptide binding]; other site 1230340000085 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1230340000086 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1230340000087 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1230340000088 putative active site [active] 1230340000089 putative metal binding site [ion binding]; other site 1230340000090 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1230340000091 beta-galactosidase; Region: BGL; TIGR03356 1230340000092 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1230340000093 Bacterial SH3 domain; Region: SH3_3; pfam08239 1230340000094 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1230340000095 putative active site [active] 1230340000096 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1230340000097 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340000098 DNA-binding site [nucleotide binding]; DNA binding site 1230340000099 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1230340000100 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1230340000101 active site 1230340000102 active pocket/dimerization site; other site 1230340000103 phosphorylation site [posttranslational modification] 1230340000104 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1230340000105 active site 1230340000106 phosphorylation site [posttranslational modification] 1230340000107 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1230340000108 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1230340000109 hypothetical protein; Provisional; Region: PRK02947 1230340000110 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1230340000111 putative active site [active] 1230340000112 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1230340000113 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 1230340000114 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1230340000115 active site turn [active] 1230340000116 phosphorylation site [posttranslational modification] 1230340000117 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1230340000118 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1230340000119 HPr interaction site; other site 1230340000120 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1230340000121 active site 1230340000122 phosphorylation site [posttranslational modification] 1230340000123 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1230340000124 putative dimer interface [polypeptide binding]; other site 1230340000125 catalytic triad [active] 1230340000126 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1230340000127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340000128 Walker A/P-loop; other site 1230340000129 ATP binding site [chemical binding]; other site 1230340000130 Q-loop/lid; other site 1230340000131 ABC transporter signature motif; other site 1230340000132 Walker B; other site 1230340000133 D-loop; other site 1230340000134 H-loop/switch region; other site 1230340000135 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 1230340000136 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 1230340000137 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1230340000138 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340000139 active site 1230340000140 motif I; other site 1230340000141 motif II; other site 1230340000142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340000143 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1230340000144 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1230340000145 DNA binding site [nucleotide binding] 1230340000146 domain linker motif; other site 1230340000147 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1230340000148 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1230340000149 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1230340000150 Butyrate kinase [Energy production and conversion]; Region: COG3426 1230340000151 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1230340000152 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1230340000153 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1230340000154 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1230340000155 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1230340000156 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1230340000157 dimer interface [polypeptide binding]; other site 1230340000158 active site 1230340000159 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1230340000160 dimer interface [polypeptide binding]; other site 1230340000161 active site 1230340000162 putrescine carbamoyltransferase; Provisional; Region: PRK02255 1230340000163 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1230340000164 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1230340000165 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1230340000166 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1230340000167 agmatine deiminase; Provisional; Region: PRK13551 1230340000168 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1230340000169 carbamate kinase; Reviewed; Region: PRK12686 1230340000170 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1230340000171 putative substrate binding site [chemical binding]; other site 1230340000172 nucleotide binding site [chemical binding]; other site 1230340000173 nucleotide binding site [chemical binding]; other site 1230340000174 homodimer interface [polypeptide binding]; other site 1230340000175 agmatine deiminase; Provisional; Region: PRK13551 1230340000176 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1230340000177 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1230340000178 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1230340000179 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1230340000180 putative active site [active] 1230340000181 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1230340000182 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1230340000183 arginine deiminase; Provisional; Region: PRK01388 1230340000184 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1230340000185 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1230340000186 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1230340000187 dimer interface [polypeptide binding]; other site 1230340000188 ssDNA binding site [nucleotide binding]; other site 1230340000189 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1230340000190 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1230340000191 Predicted membrane protein [Function unknown]; Region: COG3212 1230340000192 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1230340000193 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1230340000194 putative accessory gene regulator protein; Provisional; Region: PRK01100 1230340000195 Staphylococcal AgrD protein; Region: AgrD; cl05477 1230340000196 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1230340000197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340000198 ATP binding site [chemical binding]; other site 1230340000199 Mg2+ binding site [ion binding]; other site 1230340000200 G-X-G motif; other site 1230340000201 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1230340000202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340000203 active site 1230340000204 phosphorylation site [posttranslational modification] 1230340000205 intermolecular recognition site; other site 1230340000206 LytTr DNA-binding domain; Region: LytTR; pfam04397 1230340000207 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1230340000208 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1230340000209 DHH family; Region: DHH; pfam01368 1230340000210 DHHA1 domain; Region: DHHA1; pfam02272 1230340000211 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1230340000212 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1230340000213 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1230340000214 replicative DNA helicase; Provisional; Region: PRK05748 1230340000215 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1230340000216 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1230340000217 Walker A motif; other site 1230340000218 ATP binding site [chemical binding]; other site 1230340000219 Walker B motif; other site 1230340000220 DNA binding loops [nucleotide binding] 1230340000221 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1230340000222 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1230340000223 GDP-binding site [chemical binding]; other site 1230340000224 ACT binding site; other site 1230340000225 IMP binding site; other site 1230340000226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1230340000227 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1230340000228 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1230340000229 Predicted membrane protein [Function unknown]; Region: COG1511 1230340000230 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 1230340000231 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 1230340000232 Uncharacterized small protein [Function unknown]; Region: COG5417 1230340000233 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1230340000234 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1230340000235 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1230340000236 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1230340000237 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1230340000238 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1230340000239 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1230340000240 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1230340000241 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1230340000242 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1230340000243 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1230340000244 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1230340000245 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 1230340000246 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1230340000247 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1230340000248 tetramer interface [polypeptide binding]; other site 1230340000249 active site 1230340000250 Mg2+/Mn2+ binding site [ion binding]; other site 1230340000251 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1230340000252 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1230340000253 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1230340000254 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1230340000255 DNA binding site [nucleotide binding] 1230340000256 active site 1230340000257 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1230340000258 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1230340000259 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1230340000260 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1230340000261 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1230340000262 putative ligand binding site [chemical binding]; other site 1230340000263 putative NAD binding site [chemical binding]; other site 1230340000264 catalytic site [active] 1230340000265 LXG domain of WXG superfamily; Region: LXG; pfam04740 1230340000266 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1230340000267 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1230340000268 DNA binding residues [nucleotide binding] 1230340000269 putative dimer interface [polypeptide binding]; other site 1230340000270 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1230340000271 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1230340000272 active site 1230340000273 catalytic tetrad [active] 1230340000274 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340000275 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1230340000276 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1230340000277 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1230340000278 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 1230340000279 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1230340000280 Walker A motif; other site 1230340000281 ATP binding site [chemical binding]; other site 1230340000282 Walker B motif; other site 1230340000283 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1230340000284 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1230340000285 core domain interface [polypeptide binding]; other site 1230340000286 delta subunit interface [polypeptide binding]; other site 1230340000287 epsilon subunit interface [polypeptide binding]; other site 1230340000288 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 1230340000289 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1230340000290 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1230340000291 alpha subunit interaction interface [polypeptide binding]; other site 1230340000292 Walker A motif; other site 1230340000293 ATP binding site [chemical binding]; other site 1230340000294 Walker B motif; other site 1230340000295 inhibitor binding site; inhibition site 1230340000296 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1230340000297 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1230340000298 gamma subunit interface [polypeptide binding]; other site 1230340000299 epsilon subunit interface [polypeptide binding]; other site 1230340000300 LBP interface [polypeptide binding]; other site 1230340000301 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1230340000302 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1230340000303 active pocket/dimerization site; other site 1230340000304 active site 1230340000305 phosphorylation site [posttranslational modification] 1230340000306 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1230340000307 active site 1230340000308 phosphorylation site [posttranslational modification] 1230340000309 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1230340000310 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1230340000311 Domain of unknown function (DUF956); Region: DUF956; pfam06115 1230340000312 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 1230340000313 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1230340000314 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1230340000315 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1230340000316 dimerization interface [polypeptide binding]; other site 1230340000317 putative DNA binding site [nucleotide binding]; other site 1230340000318 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1230340000319 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1230340000320 dimer interface [polypeptide binding]; other site 1230340000321 FMN binding site [chemical binding]; other site 1230340000322 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 1230340000323 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1230340000324 active site 1230340000325 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1230340000326 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1230340000327 Interdomain contacts; other site 1230340000328 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1230340000329 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1230340000330 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1230340000331 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1230340000332 nucleotide binding site [chemical binding]; other site 1230340000333 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1230340000334 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1230340000335 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1230340000336 Walker A/P-loop; other site 1230340000337 ATP binding site [chemical binding]; other site 1230340000338 Q-loop/lid; other site 1230340000339 ABC transporter signature motif; other site 1230340000340 Walker B; other site 1230340000341 D-loop; other site 1230340000342 H-loop/switch region; other site 1230340000343 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1230340000344 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1230340000345 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1230340000346 Walker A/P-loop; other site 1230340000347 ATP binding site [chemical binding]; other site 1230340000348 Q-loop/lid; other site 1230340000349 ABC transporter signature motif; other site 1230340000350 Walker B; other site 1230340000351 D-loop; other site 1230340000352 H-loop/switch region; other site 1230340000353 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1230340000354 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1230340000355 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1230340000356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1230340000357 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1230340000358 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1230340000359 substrate binding pocket [chemical binding]; other site 1230340000360 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1230340000361 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1230340000362 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340000363 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1230340000364 ligand binding site [chemical binding]; other site 1230340000365 flexible hinge region; other site 1230340000366 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1230340000367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340000368 non-specific DNA binding site [nucleotide binding]; other site 1230340000369 salt bridge; other site 1230340000370 sequence-specific DNA binding site [nucleotide binding]; other site 1230340000371 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1230340000372 Predicted secreted protein [Function unknown]; Region: COG5437 1230340000373 Phage-related protein [Function unknown]; Region: COG5412 1230340000374 Phage tail protein; Region: Sipho_tail; pfam05709 1230340000375 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1230340000376 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1230340000377 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1230340000378 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1230340000379 active site 1230340000380 metal binding site [ion binding]; metal-binding site 1230340000381 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1230340000382 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1230340000383 putative active site [active] 1230340000384 putative metal binding site [ion binding]; other site 1230340000385 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1230340000386 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1230340000387 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 1230340000388 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1230340000389 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 1230340000390 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1230340000391 active site 1230340000392 Uncharacterized conserved protein [Function unknown]; Region: COG3592 1230340000393 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340000394 Coenzyme A binding pocket [chemical binding]; other site 1230340000395 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1230340000396 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1230340000397 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1230340000398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340000399 dimer interface [polypeptide binding]; other site 1230340000400 conserved gate region; other site 1230340000401 putative PBP binding loops; other site 1230340000402 ABC-ATPase subunit interface; other site 1230340000403 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1230340000404 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1230340000405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340000406 dimer interface [polypeptide binding]; other site 1230340000407 conserved gate region; other site 1230340000408 putative PBP binding loops; other site 1230340000409 ABC-ATPase subunit interface; other site 1230340000410 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 1230340000411 LXG domain of WXG superfamily; Region: LXG; pfam04740 1230340000412 LXG domain of WXG superfamily; Region: LXG; pfam04740 1230340000413 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 1230340000414 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1230340000415 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1230340000416 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1230340000417 peptide binding site [polypeptide binding]; other site 1230340000418 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1230340000419 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1230340000420 metal binding site [ion binding]; metal-binding site 1230340000421 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1230340000422 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1230340000423 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1230340000424 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1230340000425 ABC-ATPase subunit interface; other site 1230340000426 dimer interface [polypeptide binding]; other site 1230340000427 putative PBP binding regions; other site 1230340000428 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1230340000429 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340000430 ligand binding site [chemical binding]; other site 1230340000431 flexible hinge region; other site 1230340000432 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1230340000433 DEAD_2; Region: DEAD_2; pfam06733 1230340000434 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1230340000435 sugar phosphate phosphatase; Provisional; Region: PRK10513 1230340000436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340000437 active site 1230340000438 motif I; other site 1230340000439 motif II; other site 1230340000440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340000441 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1230340000442 Collagen binding domain; Region: Collagen_bind; pfam05737 1230340000443 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340000444 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340000445 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340000446 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1230340000447 Collagen binding domain; Region: Collagen_bind; pfam05737 1230340000448 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340000449 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340000450 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1230340000451 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1230340000452 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1230340000453 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1230340000454 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 1230340000455 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1230340000456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340000457 S-adenosylmethionine binding site [chemical binding]; other site 1230340000458 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1230340000459 GIY-YIG motif/motif A; other site 1230340000460 putative active site [active] 1230340000461 putative metal binding site [ion binding]; other site 1230340000462 Predicted methyltransferases [General function prediction only]; Region: COG0313 1230340000463 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1230340000464 putative SAM binding site [chemical binding]; other site 1230340000465 putative homodimer interface [polypeptide binding]; other site 1230340000466 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1230340000467 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1230340000468 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1230340000469 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1230340000470 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1230340000471 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1230340000472 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340000473 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1230340000474 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1230340000475 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1230340000476 active site 1230340000477 KMSKS motif; other site 1230340000478 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1230340000479 tRNA binding surface [nucleotide binding]; other site 1230340000480 anticodon binding site; other site 1230340000481 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1230340000482 dimer interface [polypeptide binding]; other site 1230340000483 putative tRNA-binding site [nucleotide binding]; other site 1230340000484 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1230340000485 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1230340000486 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1230340000487 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1230340000488 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1230340000489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340000490 dimer interface [polypeptide binding]; other site 1230340000491 conserved gate region; other site 1230340000492 putative PBP binding loops; other site 1230340000493 ABC-ATPase subunit interface; other site 1230340000494 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1230340000495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340000496 dimer interface [polypeptide binding]; other site 1230340000497 conserved gate region; other site 1230340000498 putative PBP binding loops; other site 1230340000499 ABC-ATPase subunit interface; other site 1230340000500 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1230340000501 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1230340000502 alpha-glucosidase; Provisional; Region: PRK10426 1230340000503 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1230340000504 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1230340000505 active site 1230340000506 catalytic site [active] 1230340000507 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1230340000508 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1230340000509 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1230340000510 trimer interface [polypeptide binding]; other site 1230340000511 active site 1230340000512 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1230340000513 catalytic site [active] 1230340000514 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1230340000515 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1230340000516 Ca binding site [ion binding]; other site 1230340000517 active site 1230340000518 catalytic site [active] 1230340000519 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1230340000520 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1230340000521 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1230340000522 active site 1230340000523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1230340000524 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1230340000525 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1230340000526 G5 domain; Region: G5; pfam07501 1230340000527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1230340000528 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1230340000529 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1230340000530 putative active site [active] 1230340000531 putative metal binding site [ion binding]; other site 1230340000532 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1230340000533 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1230340000534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340000535 S-adenosylmethionine binding site [chemical binding]; other site 1230340000536 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1230340000537 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1230340000538 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1230340000539 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1230340000540 putative active site [active] 1230340000541 YdjC motif; other site 1230340000542 Mg binding site [ion binding]; other site 1230340000543 putative homodimer interface [polypeptide binding]; other site 1230340000544 pur operon repressor; Provisional; Region: PRK09213 1230340000545 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1230340000546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1230340000547 active site 1230340000548 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1230340000549 HlyD family secretion protein; Region: HlyD_3; pfam13437 1230340000550 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1230340000551 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1230340000552 Walker A/P-loop; other site 1230340000553 ATP binding site [chemical binding]; other site 1230340000554 Q-loop/lid; other site 1230340000555 ABC transporter signature motif; other site 1230340000556 Walker B; other site 1230340000557 D-loop; other site 1230340000558 H-loop/switch region; other site 1230340000559 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1230340000560 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1230340000561 FtsX-like permease family; Region: FtsX; pfam02687 1230340000562 regulatory protein SpoVG; Reviewed; Region: PRK13259 1230340000563 regulatory protein SpoVG; Reviewed; Region: PRK13259 1230340000564 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1230340000565 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1230340000566 Substrate binding site; other site 1230340000567 Mg++ binding site; other site 1230340000568 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1230340000569 active site 1230340000570 substrate binding site [chemical binding]; other site 1230340000571 CoA binding site [chemical binding]; other site 1230340000572 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1230340000573 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1230340000574 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1230340000575 active site 1230340000576 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340000577 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1230340000578 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1230340000579 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 1230340000580 active site 1230340000581 catalytic site [active] 1230340000582 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 1230340000583 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1230340000584 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1230340000585 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1230340000586 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1230340000587 active site 1230340000588 Zn binding site [ion binding]; other site 1230340000589 ActA Protein; Region: ActA; pfam05058 1230340000590 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 1230340000591 Zn binding site [ion binding]; other site 1230340000592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1230340000593 hypothetical protein; Provisional; Region: PRK01119 1230340000594 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1230340000595 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1230340000596 active site 1230340000597 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1230340000598 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1230340000599 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1230340000600 NAD binding site [chemical binding]; other site 1230340000601 dimer interface [polypeptide binding]; other site 1230340000602 substrate binding site [chemical binding]; other site 1230340000603 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1230340000604 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1230340000605 5S rRNA interface [nucleotide binding]; other site 1230340000606 CTC domain interface [polypeptide binding]; other site 1230340000607 L16 interface [polypeptide binding]; other site 1230340000608 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1230340000609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340000610 Coenzyme A binding pocket [chemical binding]; other site 1230340000611 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1230340000612 putative active site [active] 1230340000613 catalytic residue [active] 1230340000614 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1230340000615 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1230340000616 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1230340000617 ATP binding site [chemical binding]; other site 1230340000618 putative Mg++ binding site [ion binding]; other site 1230340000619 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1230340000620 nucleotide binding region [chemical binding]; other site 1230340000621 ATP-binding site [chemical binding]; other site 1230340000622 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1230340000623 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1230340000624 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1230340000625 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1230340000626 RNA binding surface [nucleotide binding]; other site 1230340000627 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1230340000628 Septum formation initiator; Region: DivIC; pfam04977 1230340000629 hypothetical protein; Provisional; Region: PRK08582 1230340000630 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1230340000631 RNA binding site [nucleotide binding]; other site 1230340000632 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1230340000633 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1230340000634 Ligand Binding Site [chemical binding]; other site 1230340000635 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1230340000636 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1230340000637 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1230340000638 active site 1230340000639 FtsH Extracellular; Region: FtsH_ext; pfam06480 1230340000640 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1230340000641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340000642 Walker A motif; other site 1230340000643 ATP binding site [chemical binding]; other site 1230340000644 Walker B motif; other site 1230340000645 arginine finger; other site 1230340000646 Peptidase family M41; Region: Peptidase_M41; pfam01434 1230340000647 pantothenate kinase; Reviewed; Region: PRK13318 1230340000648 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1230340000649 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1230340000650 dimerization interface [polypeptide binding]; other site 1230340000651 domain crossover interface; other site 1230340000652 redox-dependent activation switch; other site 1230340000653 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1230340000654 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1230340000655 dimer interface [polypeptide binding]; other site 1230340000656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340000657 catalytic residue [active] 1230340000658 dihydropteroate synthase; Region: DHPS; TIGR01496 1230340000659 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1230340000660 substrate binding pocket [chemical binding]; other site 1230340000661 dimer interface [polypeptide binding]; other site 1230340000662 inhibitor binding site; inhibition site 1230340000663 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1230340000664 homooctamer interface [polypeptide binding]; other site 1230340000665 active site 1230340000666 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1230340000667 catalytic center binding site [active] 1230340000668 ATP binding site [chemical binding]; other site 1230340000669 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1230340000670 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1230340000671 FMN binding site [chemical binding]; other site 1230340000672 active site 1230340000673 catalytic residues [active] 1230340000674 substrate binding site [chemical binding]; other site 1230340000675 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1230340000676 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1230340000677 dimer interface [polypeptide binding]; other site 1230340000678 putative anticodon binding site; other site 1230340000679 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1230340000680 motif 1; other site 1230340000681 active site 1230340000682 motif 2; other site 1230340000683 motif 3; other site 1230340000684 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1230340000685 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1230340000686 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 1230340000687 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1230340000688 ADP binding site [chemical binding]; other site 1230340000689 phosphagen binding site; other site 1230340000690 substrate specificity loop; other site 1230340000691 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1230340000692 Clp amino terminal domain; Region: Clp_N; pfam02861 1230340000693 Clp amino terminal domain; Region: Clp_N; pfam02861 1230340000694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340000695 Walker A motif; other site 1230340000696 ATP binding site [chemical binding]; other site 1230340000697 Walker B motif; other site 1230340000698 arginine finger; other site 1230340000699 UvrB/uvrC motif; Region: UVR; pfam02151 1230340000700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340000701 Walker A motif; other site 1230340000702 ATP binding site [chemical binding]; other site 1230340000703 Walker B motif; other site 1230340000704 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1230340000705 DNA repair protein RadA; Provisional; Region: PRK11823 1230340000706 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1230340000707 Walker A motif/ATP binding site; other site 1230340000708 ATP binding site [chemical binding]; other site 1230340000709 Walker B motif; other site 1230340000710 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1230340000711 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1230340000712 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1230340000713 putative active site [active] 1230340000714 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1230340000715 substrate binding site; other site 1230340000716 dimer interface; other site 1230340000717 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1230340000718 homotrimer interaction site [polypeptide binding]; other site 1230340000719 zinc binding site [ion binding]; other site 1230340000720 CDP-binding sites; other site 1230340000721 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1230340000722 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1230340000723 HIGH motif; other site 1230340000724 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1230340000725 active site 1230340000726 KMSKS motif; other site 1230340000727 serine O-acetyltransferase; Region: cysE; TIGR01172 1230340000728 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1230340000729 trimer interface [polypeptide binding]; other site 1230340000730 active site 1230340000731 substrate binding site [chemical binding]; other site 1230340000732 CoA binding site [chemical binding]; other site 1230340000733 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1230340000734 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1230340000735 active site 1230340000736 HIGH motif; other site 1230340000737 nucleotide binding site [chemical binding]; other site 1230340000738 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1230340000739 KMSKS motif; other site 1230340000740 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1230340000741 tRNA binding surface [nucleotide binding]; other site 1230340000742 anticodon binding site; other site 1230340000743 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1230340000744 active site 1230340000745 metal binding site [ion binding]; metal-binding site 1230340000746 dimerization interface [polypeptide binding]; other site 1230340000747 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1230340000748 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1230340000749 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1230340000750 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1230340000751 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1230340000752 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1230340000753 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1230340000754 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1230340000755 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1230340000756 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1230340000757 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1230340000758 putative homodimer interface [polypeptide binding]; other site 1230340000759 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1230340000760 heterodimer interface [polypeptide binding]; other site 1230340000761 homodimer interface [polypeptide binding]; other site 1230340000762 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1230340000763 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1230340000764 23S rRNA interface [nucleotide binding]; other site 1230340000765 L7/L12 interface [polypeptide binding]; other site 1230340000766 putative thiostrepton binding site; other site 1230340000767 L25 interface [polypeptide binding]; other site 1230340000768 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1230340000769 mRNA/rRNA interface [nucleotide binding]; other site 1230340000770 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1230340000771 23S rRNA interface [nucleotide binding]; other site 1230340000772 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1230340000773 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1230340000774 core dimer interface [polypeptide binding]; other site 1230340000775 peripheral dimer interface [polypeptide binding]; other site 1230340000776 L10 interface [polypeptide binding]; other site 1230340000777 L11 interface [polypeptide binding]; other site 1230340000778 putative EF-Tu interaction site [polypeptide binding]; other site 1230340000779 putative EF-G interaction site [polypeptide binding]; other site 1230340000780 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1230340000781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340000782 S-adenosylmethionine binding site [chemical binding]; other site 1230340000783 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1230340000784 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1230340000785 putative dimerization interface [polypeptide binding]; other site 1230340000786 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1230340000787 putative ligand binding site [chemical binding]; other site 1230340000788 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1230340000789 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1230340000790 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1230340000791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340000792 dimer interface [polypeptide binding]; other site 1230340000793 conserved gate region; other site 1230340000794 putative PBP binding loops; other site 1230340000795 ABC-ATPase subunit interface; other site 1230340000796 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1230340000797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340000798 dimer interface [polypeptide binding]; other site 1230340000799 conserved gate region; other site 1230340000800 putative PBP binding loops; other site 1230340000801 ABC-ATPase subunit interface; other site 1230340000802 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1230340000803 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1230340000804 Ca binding site [ion binding]; other site 1230340000805 active site 1230340000806 catalytic site [active] 1230340000807 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1230340000808 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1230340000809 active site 1230340000810 homodimer interface [polypeptide binding]; other site 1230340000811 catalytic site [active] 1230340000812 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1230340000813 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1230340000814 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1230340000815 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1230340000816 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1230340000817 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1230340000818 RPB10 interaction site [polypeptide binding]; other site 1230340000819 RPB1 interaction site [polypeptide binding]; other site 1230340000820 RPB11 interaction site [polypeptide binding]; other site 1230340000821 RPB3 interaction site [polypeptide binding]; other site 1230340000822 RPB12 interaction site [polypeptide binding]; other site 1230340000823 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1230340000824 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1230340000825 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1230340000826 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1230340000827 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1230340000828 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1230340000829 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1230340000830 G-loop; other site 1230340000831 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1230340000832 DNA binding site [nucleotide binding] 1230340000833 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1230340000834 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1230340000835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340000836 active site 1230340000837 motif I; other site 1230340000838 motif II; other site 1230340000839 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1230340000840 beta-galactosidase; Region: BGL; TIGR03356 1230340000841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340000842 Q-loop/lid; other site 1230340000843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1230340000844 ABC transporter signature motif; other site 1230340000845 ABC transporter signature motif; other site 1230340000846 Walker B; other site 1230340000847 Walker B; other site 1230340000848 D-loop; other site 1230340000849 D-loop; other site 1230340000850 H-loop/switch region; other site 1230340000851 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1230340000852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1230340000853 Walker A/P-loop; other site 1230340000854 ATP binding site [chemical binding]; other site 1230340000855 Q-loop/lid; other site 1230340000856 ABC transporter signature motif; other site 1230340000857 Walker B; other site 1230340000858 D-loop; other site 1230340000859 H-loop/switch region; other site 1230340000860 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1230340000861 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1230340000862 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1230340000863 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000864 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000865 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000866 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000867 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000868 LRR adjacent; Region: LRR_adjacent; pfam08191 1230340000869 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340000870 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340000871 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1230340000872 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1230340000873 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000874 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000875 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000876 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000877 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000878 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000879 LRR adjacent; Region: LRR_adjacent; pfam08191 1230340000880 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340000881 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340000882 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1230340000883 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000884 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000885 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1230340000886 Leucine-rich repeats; other site 1230340000887 Substrate binding site [chemical binding]; other site 1230340000888 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000889 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000890 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000891 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000892 LRR adjacent; Region: LRR_adjacent; pfam08191 1230340000893 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340000894 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340000895 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1230340000896 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1230340000897 metal binding site [ion binding]; metal-binding site 1230340000898 dimer interface [polypeptide binding]; other site 1230340000899 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1230340000900 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1230340000901 putative Zn2+ binding site [ion binding]; other site 1230340000902 putative DNA binding site [nucleotide binding]; other site 1230340000903 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1230340000904 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1230340000905 Zn binding site [ion binding]; other site 1230340000906 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1230340000907 Zn binding site [ion binding]; other site 1230340000908 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1230340000909 catalytic core [active] 1230340000910 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1230340000911 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1230340000912 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1230340000913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340000914 dimer interface [polypeptide binding]; other site 1230340000915 conserved gate region; other site 1230340000916 ABC-ATPase subunit interface; other site 1230340000917 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1230340000918 Substrate binding site [chemical binding]; other site 1230340000919 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000920 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000921 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000922 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000923 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340000924 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1230340000925 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1230340000926 beta-galactosidase; Region: BGL; TIGR03356 1230340000927 sugar phosphate phosphatase; Provisional; Region: PRK10513 1230340000928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340000929 active site 1230340000930 motif I; other site 1230340000931 motif II; other site 1230340000932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340000933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340000934 Coenzyme A binding pocket [chemical binding]; other site 1230340000935 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340000936 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1230340000937 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1230340000938 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1230340000939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340000940 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1230340000941 active site 1230340000942 motif I; other site 1230340000943 motif II; other site 1230340000944 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340000945 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1230340000946 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1230340000947 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1230340000948 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1230340000949 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1230340000950 Walker A/P-loop; other site 1230340000951 ATP binding site [chemical binding]; other site 1230340000952 Q-loop/lid; other site 1230340000953 ABC transporter signature motif; other site 1230340000954 Walker B; other site 1230340000955 D-loop; other site 1230340000956 H-loop/switch region; other site 1230340000957 TOBE domain; Region: TOBE; pfam03459 1230340000958 ATP cone domain; Region: ATP-cone; pfam03477 1230340000959 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1230340000960 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1230340000961 effector binding site; other site 1230340000962 active site 1230340000963 Zn binding site [ion binding]; other site 1230340000964 glycine loop; other site 1230340000965 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1230340000966 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1230340000967 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340000968 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1230340000969 ligand binding site [chemical binding]; other site 1230340000970 flexible hinge region; other site 1230340000971 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1230340000972 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1230340000973 putative active site [active] 1230340000974 catalytic triad [active] 1230340000975 putative dimer interface [polypeptide binding]; other site 1230340000976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340000977 dimer interface [polypeptide binding]; other site 1230340000978 conserved gate region; other site 1230340000979 ABC-ATPase subunit interface; other site 1230340000980 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1230340000981 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1230340000982 Walker A/P-loop; other site 1230340000983 ATP binding site [chemical binding]; other site 1230340000984 Q-loop/lid; other site 1230340000985 ABC transporter signature motif; other site 1230340000986 Walker B; other site 1230340000987 D-loop; other site 1230340000988 H-loop/switch region; other site 1230340000989 NIL domain; Region: NIL; pfam09383 1230340000990 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1230340000991 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1230340000992 transaminase; Reviewed; Region: PRK08068 1230340000993 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1230340000994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340000995 homodimer interface [polypeptide binding]; other site 1230340000996 catalytic residue [active] 1230340000997 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1230340000998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340000999 active site 1230340001000 phosphorylation site [posttranslational modification] 1230340001001 intermolecular recognition site; other site 1230340001002 dimerization interface [polypeptide binding]; other site 1230340001003 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1230340001004 DNA binding site [nucleotide binding] 1230340001005 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1230340001006 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1230340001007 dimerization interface [polypeptide binding]; other site 1230340001008 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1230340001009 putative active site [active] 1230340001010 heme pocket [chemical binding]; other site 1230340001011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1230340001012 dimer interface [polypeptide binding]; other site 1230340001013 phosphorylation site [posttranslational modification] 1230340001014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340001015 ATP binding site [chemical binding]; other site 1230340001016 Mg2+ binding site [ion binding]; other site 1230340001017 G-X-G motif; other site 1230340001018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1230340001019 YycH protein; Region: YycH; pfam07435 1230340001020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 1230340001021 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1230340001022 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1230340001023 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1230340001024 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1230340001025 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1230340001026 protein binding site [polypeptide binding]; other site 1230340001027 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1230340001028 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1230340001029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1230340001030 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1230340001031 dimerization interface [polypeptide binding]; other site 1230340001032 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1230340001033 dimer interface [polypeptide binding]; other site 1230340001034 FMN binding site [chemical binding]; other site 1230340001035 NADPH bind site [chemical binding]; other site 1230340001036 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1230340001037 HTH domain; Region: HTH_11; pfam08279 1230340001038 Mga helix-turn-helix domain; Region: Mga; pfam05043 1230340001039 PRD domain; Region: PRD; pfam00874 1230340001040 PRD domain; Region: PRD; pfam00874 1230340001041 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1230340001042 active site 1230340001043 P-loop; other site 1230340001044 phosphorylation site [posttranslational modification] 1230340001045 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340001046 active site 1230340001047 phosphorylation site [posttranslational modification] 1230340001048 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1230340001049 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1230340001050 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1230340001051 active site 1230340001052 P-loop; other site 1230340001053 phosphorylation site [posttranslational modification] 1230340001054 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1230340001055 beta-galactosidase; Region: BGL; TIGR03356 1230340001056 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1230340001057 methionine cluster; other site 1230340001058 active site 1230340001059 phosphorylation site [posttranslational modification] 1230340001060 metal binding site [ion binding]; metal-binding site 1230340001061 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1230340001062 putative active site [active] 1230340001063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340001064 non-specific DNA binding site [nucleotide binding]; other site 1230340001065 salt bridge; other site 1230340001066 sequence-specific DNA binding site [nucleotide binding]; other site 1230340001067 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1230340001068 cofactor binding site; other site 1230340001069 DNA binding site [nucleotide binding] 1230340001070 substrate interaction site [chemical binding]; other site 1230340001071 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1230340001072 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1230340001073 active site 1230340001074 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1230340001075 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1230340001076 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1230340001077 catalytic residue [active] 1230340001078 Peptidase family M48; Region: Peptidase_M48; cl12018 1230340001079 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1230340001080 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 1230340001081 putative active site [active] 1230340001082 YdjC motif; other site 1230340001083 Mg binding site [ion binding]; other site 1230340001084 putative homodimer interface [polypeptide binding]; other site 1230340001085 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1230340001086 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1230340001087 substrate binding site [chemical binding]; other site 1230340001088 multimerization interface [polypeptide binding]; other site 1230340001089 ATP binding site [chemical binding]; other site 1230340001090 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1230340001091 dimer interface [polypeptide binding]; other site 1230340001092 substrate binding site [chemical binding]; other site 1230340001093 ATP binding site [chemical binding]; other site 1230340001094 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1230340001095 thiamine phosphate binding site [chemical binding]; other site 1230340001096 active site 1230340001097 pyrophosphate binding site [ion binding]; other site 1230340001098 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1230340001099 beta-galactosidase; Region: BGL; TIGR03356 1230340001100 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340001101 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1230340001102 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 1230340001103 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 1230340001104 putative catalytic site [active] 1230340001105 putative metal binding site [ion binding]; other site 1230340001106 putative phosphate binding site [ion binding]; other site 1230340001107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340001108 non-specific DNA binding site [nucleotide binding]; other site 1230340001109 salt bridge; other site 1230340001110 sequence-specific DNA binding site [nucleotide binding]; other site 1230340001111 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1230340001112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340001113 non-specific DNA binding site [nucleotide binding]; other site 1230340001114 salt bridge; other site 1230340001115 sequence-specific DNA binding site [nucleotide binding]; other site 1230340001116 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1230340001117 Leucine rich repeat; Region: LRR_8; pfam13855 1230340001118 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001119 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001120 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001121 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001122 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001123 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001124 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001125 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001126 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001127 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001128 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001129 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001130 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001131 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001132 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001133 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001134 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340001135 Leucine rich repeat; Region: LRR_8; pfam13855 1230340001136 LRR adjacent; Region: LRR_adjacent; pfam08191 1230340001137 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340001138 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1230340001139 Leucine-rich repeats; other site 1230340001140 Substrate binding site [chemical binding]; other site 1230340001141 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001142 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001143 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001144 Leucine rich repeat; Region: LRR_8; pfam13855 1230340001145 Leucine rich repeat; Region: LRR_8; pfam13855 1230340001146 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1230340001147 Leucine-rich repeats; other site 1230340001148 Substrate binding site [chemical binding]; other site 1230340001149 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001150 Leucine rich repeat; Region: LRR_8; pfam13855 1230340001151 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001152 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001153 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001154 LRR adjacent; Region: LRR_adjacent; pfam08191 1230340001155 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001156 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001157 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001158 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340001159 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1230340001160 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 1230340001161 LXG domain of WXG superfamily; Region: LXG; pfam04740 1230340001162 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1230340001163 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1230340001164 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1230340001165 TPP-binding site [chemical binding]; other site 1230340001166 dimer interface [polypeptide binding]; other site 1230340001167 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1230340001168 PYR/PP interface [polypeptide binding]; other site 1230340001169 dimer interface [polypeptide binding]; other site 1230340001170 TPP binding site [chemical binding]; other site 1230340001171 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1230340001172 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1230340001173 active site 1230340001174 intersubunit interactions; other site 1230340001175 catalytic residue [active] 1230340001176 short chain dehydrogenase; Provisional; Region: PRK06841 1230340001177 classical (c) SDRs; Region: SDR_c; cd05233 1230340001178 NAD(P) binding site [chemical binding]; other site 1230340001179 active site 1230340001180 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1230340001181 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1230340001182 substrate binding site [chemical binding]; other site 1230340001183 dimer interface [polypeptide binding]; other site 1230340001184 catalytic triad [active] 1230340001185 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1230340001186 DAK2 domain; Region: Dak2; cl03685 1230340001187 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1230340001188 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1230340001189 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 1230340001190 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1230340001191 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1230340001192 putative DNA binding site [nucleotide binding]; other site 1230340001193 putative Zn2+ binding site [ion binding]; other site 1230340001194 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1230340001195 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340001196 Coenzyme A binding pocket [chemical binding]; other site 1230340001197 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1230340001198 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1230340001199 LRR adjacent; Region: LRR_adjacent; pfam08191 1230340001200 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340001201 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340001202 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1230340001203 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1230340001204 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1230340001205 acyl-activating enzyme (AAE) consensus motif; other site 1230340001206 acyl-activating enzyme (AAE) consensus motif; other site 1230340001207 AMP binding site [chemical binding]; other site 1230340001208 active site 1230340001209 CoA binding site [chemical binding]; other site 1230340001210 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1230340001211 L-aspartate oxidase; Provisional; Region: PRK06175 1230340001212 putative oxidoreductase; Provisional; Region: PRK10206 1230340001213 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1230340001214 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1230340001215 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340001216 active site 1230340001217 phosphorylation site [posttranslational modification] 1230340001218 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1230340001219 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1230340001220 active site 1230340001221 P-loop; other site 1230340001222 phosphorylation site [posttranslational modification] 1230340001223 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1230340001224 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1230340001225 intersubunit interface [polypeptide binding]; other site 1230340001226 active site 1230340001227 zinc binding site [ion binding]; other site 1230340001228 Na+ binding site [ion binding]; other site 1230340001229 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1230340001230 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1230340001231 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1230340001232 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1230340001233 conserved cys residue [active] 1230340001234 Predicted transcriptional regulator [Transcription]; Region: COG2378 1230340001235 HTH domain; Region: HTH_11; pfam08279 1230340001236 WYL domain; Region: WYL; pfam13280 1230340001237 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 1230340001238 nudix motif; other site 1230340001239 hypothetical protein; Provisional; Region: PRK12378 1230340001240 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1230340001241 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1230340001242 PhnA protein; Region: PhnA; pfam03831 1230340001243 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1230340001244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340001245 DNA-binding site [nucleotide binding]; DNA binding site 1230340001246 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1230340001247 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1230340001248 beta-galactosidase; Region: BGL; TIGR03356 1230340001249 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1230340001250 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1230340001251 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1230340001252 active site 1230340001253 P-loop; other site 1230340001254 phosphorylation site [posttranslational modification] 1230340001255 Predicted transcriptional regulator [Transcription]; Region: COG2378 1230340001256 HTH domain; Region: HTH_11; pfam08279 1230340001257 WYL domain; Region: WYL; pfam13280 1230340001258 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1230340001259 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1230340001260 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1230340001261 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1230340001262 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1230340001263 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1230340001264 tetrameric interface [polypeptide binding]; other site 1230340001265 NAD binding site [chemical binding]; other site 1230340001266 catalytic residues [active] 1230340001267 KduI/IolB family; Region: KduI; cl01508 1230340001268 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1230340001269 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1230340001270 substrate binding site [chemical binding]; other site 1230340001271 ATP binding site [chemical binding]; other site 1230340001272 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1230340001273 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1230340001274 PYR/PP interface [polypeptide binding]; other site 1230340001275 dimer interface [polypeptide binding]; other site 1230340001276 TPP binding site [chemical binding]; other site 1230340001277 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1230340001278 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1230340001279 TPP-binding site; other site 1230340001280 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1230340001281 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1230340001282 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1230340001283 ligand binding site [chemical binding]; other site 1230340001284 active site 1230340001285 UGI interface [polypeptide binding]; other site 1230340001286 catalytic site [active] 1230340001287 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1230340001288 hypothetical protein; Provisional; Region: PRK13665 1230340001289 Bacterial SH3 domain; Region: SH3_3; cl17532 1230340001290 NlpC/P60 family; Region: NLPC_P60; pfam00877 1230340001291 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1230340001292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340001293 Coenzyme A binding pocket [chemical binding]; other site 1230340001294 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1230340001295 pyrroline-5-carboxylate reductase; Region: PLN02688 1230340001296 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340001297 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340001298 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1230340001299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340001300 DNA-binding site [nucleotide binding]; DNA binding site 1230340001301 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1230340001302 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1230340001303 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1230340001304 Walker A/P-loop; other site 1230340001305 ATP binding site [chemical binding]; other site 1230340001306 Q-loop/lid; other site 1230340001307 ABC transporter signature motif; other site 1230340001308 Walker B; other site 1230340001309 D-loop; other site 1230340001310 H-loop/switch region; other site 1230340001311 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1230340001312 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1230340001313 FtsX-like permease family; Region: FtsX; pfam02687 1230340001314 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1230340001315 putative hydrophobic ligand binding site [chemical binding]; other site 1230340001316 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340001317 active site 1230340001318 phosphorylation site [posttranslational modification] 1230340001319 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1230340001320 active site 1230340001321 P-loop; other site 1230340001322 phosphorylation site [posttranslational modification] 1230340001323 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1230340001324 alpha-mannosidase; Provisional; Region: PRK09819 1230340001325 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 1230340001326 active site 1230340001327 metal binding site [ion binding]; metal-binding site 1230340001328 catalytic site [active] 1230340001329 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1230340001330 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1230340001331 HTH domain; Region: HTH_11; pfam08279 1230340001332 Mga helix-turn-helix domain; Region: Mga; pfam05043 1230340001333 PRD domain; Region: PRD; pfam00874 1230340001334 PRD domain; Region: PRD; pfam00874 1230340001335 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1230340001336 active site 1230340001337 P-loop; other site 1230340001338 phosphorylation site [posttranslational modification] 1230340001339 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340001340 active site 1230340001341 phosphorylation site [posttranslational modification] 1230340001342 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1230340001343 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1230340001344 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1230340001345 putative metal binding site [ion binding]; other site 1230340001346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 1230340001347 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 1230340001348 trimer interface [polypeptide binding]; other site 1230340001349 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1230340001350 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001351 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1230340001352 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001353 Leucine-rich repeats; other site 1230340001354 Substrate binding site [chemical binding]; other site 1230340001355 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001356 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001357 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001358 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001359 LRR adjacent; Region: LRR_adjacent; pfam08191 1230340001360 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340001361 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340001362 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340001363 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340001364 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340001365 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1230340001366 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1230340001367 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1230340001368 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1230340001369 ZIP Zinc transporter; Region: Zip; pfam02535 1230340001370 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1230340001371 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 1230340001372 NodB motif; other site 1230340001373 active site 1230340001374 catalytic site [active] 1230340001375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340001376 non-specific DNA binding site [nucleotide binding]; other site 1230340001377 salt bridge; other site 1230340001378 sequence-specific DNA binding site [nucleotide binding]; other site 1230340001379 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1230340001380 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1230340001381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340001382 active site 1230340001383 motif I; other site 1230340001384 motif II; other site 1230340001385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340001386 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1230340001387 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1230340001388 HTH domain; Region: HTH_11; pfam08279 1230340001389 PRD domain; Region: PRD; pfam00874 1230340001390 PRD domain; Region: PRD; pfam00874 1230340001391 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1230340001392 active site 1230340001393 P-loop; other site 1230340001394 phosphorylation site [posttranslational modification] 1230340001395 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340001396 active site 1230340001397 phosphorylation site [posttranslational modification] 1230340001398 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340001399 active site 1230340001400 phosphorylation site [posttranslational modification] 1230340001401 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1230340001402 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1230340001403 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 1230340001404 active site 1230340001405 metal binding site [ion binding]; metal-binding site 1230340001406 catalytic site [active] 1230340001407 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 1230340001408 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1230340001409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1230340001410 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1230340001411 dimerization interface [polypeptide binding]; other site 1230340001412 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1230340001413 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1230340001414 active site 1230340001415 substrate binding site [chemical binding]; other site 1230340001416 trimer interface [polypeptide binding]; other site 1230340001417 CoA binding site [chemical binding]; other site 1230340001418 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1230340001419 classical (c) SDRs; Region: SDR_c; cd05233 1230340001420 NAD(P) binding site [chemical binding]; other site 1230340001421 active site 1230340001422 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1230340001423 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1230340001424 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1230340001425 RHS Repeat; Region: RHS_repeat; pfam05593 1230340001426 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1230340001427 RHS Repeat; Region: RHS_repeat; pfam05593 1230340001428 RHS Repeat; Region: RHS_repeat; pfam05593 1230340001429 RHS Repeat; Region: RHS_repeat; pfam05593 1230340001430 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1230340001431 HEAT repeats; Region: HEAT_2; pfam13646 1230340001432 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1230340001433 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1230340001434 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1230340001435 Substrate binding site [chemical binding]; other site 1230340001436 LRR adjacent; Region: LRR_adjacent; pfam08191 1230340001437 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340001438 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340001439 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340001440 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1230340001441 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1230340001442 Leucine rich repeat; Region: LRR_8; pfam13855 1230340001443 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1230340001444 Leucine rich repeat; Region: LRR_8; pfam13855 1230340001445 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001446 LRR adjacent; Region: LRR_adjacent; pfam08191 1230340001447 Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543 1230340001448 SH3-like domain; Region: SH3_8; pfam13457 1230340001449 Predicted transcriptional regulator [Transcription]; Region: COG1959 1230340001450 Transcriptional regulator; Region: Rrf2; pfam02082 1230340001451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1230340001452 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1230340001453 NAD(P) binding site [chemical binding]; other site 1230340001454 active site 1230340001455 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1230340001456 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 1230340001457 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1230340001458 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1230340001459 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1230340001460 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1230340001461 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1230340001462 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 1230340001463 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 1230340001464 Predicted membrane protein [Function unknown]; Region: COG3619 1230340001465 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1230340001466 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1230340001467 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1230340001468 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1230340001469 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1230340001470 Protein of unknown function DUF58; Region: DUF58; pfam01882 1230340001471 MoxR-like ATPases [General function prediction only]; Region: COG0714 1230340001472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340001473 Walker A motif; other site 1230340001474 ATP binding site [chemical binding]; other site 1230340001475 Walker B motif; other site 1230340001476 arginine finger; other site 1230340001477 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1230340001478 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1230340001479 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1230340001480 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1230340001481 Na binding site [ion binding]; other site 1230340001482 Uncharacterized conserved protein [Function unknown]; Region: COG3535 1230340001483 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1230340001484 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1230340001485 nucleotide binding site [chemical binding]; other site 1230340001486 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1230340001487 Mga helix-turn-helix domain; Region: Mga; pfam05043 1230340001488 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1230340001489 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001490 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001491 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001492 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001493 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001494 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1230340001495 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001496 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001497 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001498 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001499 Leucine rich repeat; Region: LRR_8; pfam13855 1230340001500 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340001501 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1230340001502 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001503 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001504 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001505 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1230340001506 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001507 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001508 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001509 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001510 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340001511 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340001512 Transposase; Region: HTH_Tnp_1; cl17663 1230340001513 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1230340001514 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1230340001515 Zn2+ binding site [ion binding]; other site 1230340001516 Mg2+ binding site [ion binding]; other site 1230340001517 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1230340001518 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1230340001519 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1230340001520 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1230340001521 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1230340001522 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1230340001523 FeS/SAM binding site; other site 1230340001524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1230340001525 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 1230340001526 LXG domain of WXG superfamily; Region: LXG; pfam04740 1230340001527 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1230340001528 putative FMN binding site [chemical binding]; other site 1230340001529 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 1230340001530 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1230340001531 nudix motif; other site 1230340001532 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1230340001533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1230340001534 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1230340001535 putative dimerization interface [polypeptide binding]; other site 1230340001536 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1230340001537 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1230340001538 active site 1230340001539 FMN binding site [chemical binding]; other site 1230340001540 substrate binding site [chemical binding]; other site 1230340001541 putative catalytic residue [active] 1230340001542 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1230340001543 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1230340001544 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1230340001545 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1230340001546 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1230340001547 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1230340001548 shikimate binding site; other site 1230340001549 NAD(P) binding site [chemical binding]; other site 1230340001550 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1230340001551 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1230340001552 active site 1230340001553 catalytic residue [active] 1230340001554 dimer interface [polypeptide binding]; other site 1230340001555 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1230340001556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1230340001557 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1230340001558 dimerization interface [polypeptide binding]; other site 1230340001559 substrate binding pocket [chemical binding]; other site 1230340001560 Predicted acyl esterases [General function prediction only]; Region: COG2936 1230340001561 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1230340001562 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 1230340001563 active site 1230340001564 catalytic triad [active] 1230340001565 oxyanion hole [active] 1230340001566 EamA-like transporter family; Region: EamA; pfam00892 1230340001567 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1230340001568 EamA-like transporter family; Region: EamA; pfam00892 1230340001569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1230340001570 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1230340001571 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1230340001572 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1230340001573 substrate binding site [chemical binding]; other site 1230340001574 hexamer interface [polypeptide binding]; other site 1230340001575 metal binding site [ion binding]; metal-binding site 1230340001576 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 1230340001577 catalytic residue [active] 1230340001578 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1230340001579 PRD domain; Region: PRD; pfam00874 1230340001580 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1230340001581 active site 1230340001582 P-loop; other site 1230340001583 phosphorylation site [posttranslational modification] 1230340001584 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340001585 active site 1230340001586 phosphorylation site [posttranslational modification] 1230340001587 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1230340001588 putative active site [active] 1230340001589 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340001590 active site 1230340001591 phosphorylation site [posttranslational modification] 1230340001592 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1230340001593 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1230340001594 substrate binding site [chemical binding]; other site 1230340001595 hexamer interface [polypeptide binding]; other site 1230340001596 metal binding site [ion binding]; metal-binding site 1230340001597 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1230340001598 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1230340001599 putative NAD(P) binding site [chemical binding]; other site 1230340001600 catalytic Zn binding site [ion binding]; other site 1230340001601 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1230340001602 active site 1230340001603 P-loop; other site 1230340001604 phosphorylation site [posttranslational modification] 1230340001605 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1230340001606 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1230340001607 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1230340001608 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1230340001609 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1230340001610 active site 1230340001611 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1230340001612 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1230340001613 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1230340001614 catalytic triad [active] 1230340001615 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 1230340001616 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1230340001617 MarR family; Region: MarR_2; pfam12802 1230340001618 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001619 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340001620 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1230340001621 Ligand Binding Site [chemical binding]; other site 1230340001622 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1230340001623 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1230340001624 putative active site [active] 1230340001625 putative metal binding site [ion binding]; other site 1230340001626 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1230340001627 catalytic core [active] 1230340001628 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1230340001629 Predicted membrane protein [Function unknown]; Region: COG3759 1230340001630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340001631 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1230340001632 putative substrate translocation pore; other site 1230340001633 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1230340001634 non-specific DNA interactions [nucleotide binding]; other site 1230340001635 DNA binding site [nucleotide binding] 1230340001636 sequence specific DNA binding site [nucleotide binding]; other site 1230340001637 putative cAMP binding site [chemical binding]; other site 1230340001638 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1230340001639 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1230340001640 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1230340001641 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1230340001642 NAD binding site [chemical binding]; other site 1230340001643 sugar binding site [chemical binding]; other site 1230340001644 divalent metal binding site [ion binding]; other site 1230340001645 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1230340001646 dimer interface [polypeptide binding]; other site 1230340001647 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1230340001648 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1230340001649 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1230340001650 putative active site [active] 1230340001651 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1230340001652 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1230340001653 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1230340001654 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1230340001655 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1230340001656 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1230340001657 DNA binding residues [nucleotide binding] 1230340001658 dimer interface [polypeptide binding]; other site 1230340001659 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1230340001660 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1230340001661 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1230340001662 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1230340001663 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1230340001664 DXD motif; other site 1230340001665 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1230340001666 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1230340001667 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1230340001668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340001669 S-adenosylmethionine binding site [chemical binding]; other site 1230340001670 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1230340001671 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1230340001672 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1230340001673 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1230340001674 DNA binding site [nucleotide binding] 1230340001675 domain linker motif; other site 1230340001676 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1230340001677 putative dimerization interface [polypeptide binding]; other site 1230340001678 putative ligand binding site [chemical binding]; other site 1230340001679 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1230340001680 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1230340001681 NAD binding site [chemical binding]; other site 1230340001682 sugar binding site [chemical binding]; other site 1230340001683 divalent metal binding site [ion binding]; other site 1230340001684 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1230340001685 dimer interface [polypeptide binding]; other site 1230340001686 allantoate amidohydrolase; Reviewed; Region: PRK09290 1230340001687 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1230340001688 active site 1230340001689 metal binding site [ion binding]; metal-binding site 1230340001690 dimer interface [polypeptide binding]; other site 1230340001691 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1230340001692 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 1230340001693 metal binding site [ion binding]; metal-binding site 1230340001694 putative dimer interface [polypeptide binding]; other site 1230340001695 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1230340001696 Beta-lactamase; Region: Beta-lactamase; pfam00144 1230340001697 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1230340001698 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1230340001699 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1230340001700 putative ligand binding residues [chemical binding]; other site 1230340001701 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1230340001702 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1230340001703 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1230340001704 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1230340001705 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 1230340001706 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1230340001707 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 1230340001708 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1230340001709 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 1230340001710 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1230340001711 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1230340001712 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340001713 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 1230340001714 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001715 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001716 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001717 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340001718 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1230340001719 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1230340001720 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1230340001721 FOG: CBS domain [General function prediction only]; Region: COG0517 1230340001722 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1230340001723 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1230340001724 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1230340001725 dimer interface [polypeptide binding]; other site 1230340001726 active site 1230340001727 metal binding site [ion binding]; metal-binding site 1230340001728 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1230340001729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340001730 putative substrate translocation pore; other site 1230340001731 POT family; Region: PTR2; pfam00854 1230340001732 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1230340001733 catalytic core [active] 1230340001734 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1230340001735 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1230340001736 catalytic core [active] 1230340001737 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1230340001738 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1230340001739 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1230340001740 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1230340001741 Cl binding site [ion binding]; other site 1230340001742 oligomer interface [polypeptide binding]; other site 1230340001743 glutamate dehydrogenase; Provisional; Region: PRK09414 1230340001744 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1230340001745 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1230340001746 NAD(P) binding site [chemical binding]; other site 1230340001747 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1230340001748 metal binding site [ion binding]; metal-binding site 1230340001749 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1230340001750 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1230340001751 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1230340001752 substrate binding site [chemical binding]; other site 1230340001753 glutamase interaction surface [polypeptide binding]; other site 1230340001754 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1230340001755 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1230340001756 catalytic residues [active] 1230340001757 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1230340001758 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1230340001759 putative active site [active] 1230340001760 oxyanion strand; other site 1230340001761 catalytic triad [active] 1230340001762 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1230340001763 putative active site pocket [active] 1230340001764 4-fold oligomerization interface [polypeptide binding]; other site 1230340001765 metal binding residues [ion binding]; metal-binding site 1230340001766 3-fold/trimer interface [polypeptide binding]; other site 1230340001767 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1230340001768 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1230340001769 NAD binding site [chemical binding]; other site 1230340001770 dimerization interface [polypeptide binding]; other site 1230340001771 product binding site; other site 1230340001772 substrate binding site [chemical binding]; other site 1230340001773 zinc binding site [ion binding]; other site 1230340001774 catalytic residues [active] 1230340001775 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1230340001776 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1230340001777 dimer interface [polypeptide binding]; other site 1230340001778 motif 1; other site 1230340001779 active site 1230340001780 motif 2; other site 1230340001781 motif 3; other site 1230340001782 histidinol-phosphatase; Reviewed; Region: PRK08123 1230340001783 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1230340001784 active site 1230340001785 dimer interface [polypeptide binding]; other site 1230340001786 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1230340001787 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1230340001788 DNA binding site [nucleotide binding] 1230340001789 active site 1230340001790 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 1230340001791 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1230340001792 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1230340001793 beta-galactosidase; Region: BGL; TIGR03356 1230340001794 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1230340001795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340001796 DNA-binding site [nucleotide binding]; DNA binding site 1230340001797 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1230340001798 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001799 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340001800 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1230340001801 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1230340001802 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1230340001803 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1230340001804 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 1230340001805 Predicted esterase [General function prediction only]; Region: COG0400 1230340001806 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1230340001807 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1230340001808 putative RNA binding site [nucleotide binding]; other site 1230340001809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340001810 S-adenosylmethionine binding site [chemical binding]; other site 1230340001811 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 1230340001812 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1230340001813 Bacterial SH3 domain; Region: SH3_3; pfam08239 1230340001814 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1230340001815 NlpC/P60 family; Region: NLPC_P60; pfam00877 1230340001816 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 1230340001817 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1230340001818 ATP binding site [chemical binding]; other site 1230340001819 putative Mg++ binding site [ion binding]; other site 1230340001820 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1230340001821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1230340001822 nucleotide binding region [chemical binding]; other site 1230340001823 ATP-binding site [chemical binding]; other site 1230340001824 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1230340001825 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1230340001826 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1230340001827 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1230340001828 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1230340001829 UreD urease accessory protein; Region: UreD; cl00530 1230340001830 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1230340001831 DNA photolyase; Region: DNA_photolyase; pfam00875 1230340001832 Predicted membrane protein [Function unknown]; Region: COG4852 1230340001833 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1230340001834 DAK2 domain; Region: Dak2; pfam02734 1230340001835 EDD domain protein, DegV family; Region: DegV; TIGR00762 1230340001836 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1230340001837 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 1230340001838 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1230340001839 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1230340001840 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1230340001841 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 1230340001842 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1230340001843 homodimer interface [polypeptide binding]; other site 1230340001844 substrate-cofactor binding pocket; other site 1230340001845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340001846 catalytic residue [active] 1230340001847 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1230340001848 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340001849 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1230340001850 ligand binding site [chemical binding]; other site 1230340001851 flexible hinge region; other site 1230340001852 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1230340001853 BioY family; Region: BioY; pfam02632 1230340001854 Predicted transcriptional regulators [Transcription]; Region: COG1695 1230340001855 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1230340001856 Predicted membrane protein [Function unknown]; Region: COG4709 1230340001857 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1230340001858 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1230340001859 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1230340001860 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1230340001861 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1230340001862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340001863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1230340001864 Coenzyme A binding pocket [chemical binding]; other site 1230340001865 Tic20-like protein; Region: Tic20; pfam09685 1230340001866 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1230340001867 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1230340001868 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1230340001869 MarR family; Region: MarR_2; pfam12802 1230340001870 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1230340001871 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1230340001872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340001873 Walker A/P-loop; other site 1230340001874 ATP binding site [chemical binding]; other site 1230340001875 Q-loop/lid; other site 1230340001876 ABC transporter signature motif; other site 1230340001877 Walker B; other site 1230340001878 D-loop; other site 1230340001879 H-loop/switch region; other site 1230340001880 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1230340001881 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1230340001882 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1230340001883 Walker A/P-loop; other site 1230340001884 ATP binding site [chemical binding]; other site 1230340001885 Q-loop/lid; other site 1230340001886 ABC transporter signature motif; other site 1230340001887 Walker B; other site 1230340001888 D-loop; other site 1230340001889 H-loop/switch region; other site 1230340001890 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1230340001891 active site residue [active] 1230340001892 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340001893 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1230340001894 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1230340001895 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1230340001896 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1230340001897 putative DNA binding site [nucleotide binding]; other site 1230340001898 putative Zn2+ binding site [ion binding]; other site 1230340001899 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1230340001900 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1230340001901 putative NAD(P) binding site [chemical binding]; other site 1230340001902 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1230340001903 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1230340001904 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 1230340001905 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1230340001906 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1230340001907 putative active site [active] 1230340001908 catalytic site [active] 1230340001909 putative metal binding site [ion binding]; other site 1230340001910 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1230340001911 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1230340001912 active site 1230340001913 ATP binding site [chemical binding]; other site 1230340001914 substrate binding site [chemical binding]; other site 1230340001915 activation loop (A-loop); other site 1230340001916 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1230340001917 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1230340001918 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 1230340001919 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1230340001920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340001921 Coenzyme A binding pocket [chemical binding]; other site 1230340001922 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1230340001923 active site 1230340001924 catalytic triad [active] 1230340001925 oxyanion hole [active] 1230340001926 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1230340001927 domain interaction interfaces [polypeptide binding]; other site 1230340001928 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1230340001929 domain interaction interfaces [polypeptide binding]; other site 1230340001930 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1230340001931 domain interaction interfaces [polypeptide binding]; other site 1230340001932 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1230340001933 domain interaction interfaces [polypeptide binding]; other site 1230340001934 Isochorismatase family; Region: Isochorismatase; pfam00857 1230340001935 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1230340001936 catalytic triad [active] 1230340001937 conserved cis-peptide bond; other site 1230340001938 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1230340001939 PRD domain; Region: PRD; pfam00874 1230340001940 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1230340001941 active site 1230340001942 P-loop; other site 1230340001943 phosphorylation site [posttranslational modification] 1230340001944 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340001945 active site 1230340001946 phosphorylation site [posttranslational modification] 1230340001947 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340001948 active site 1230340001949 phosphorylation site [posttranslational modification] 1230340001950 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 1230340001951 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1230340001952 active site 1230340001953 P-loop; other site 1230340001954 phosphorylation site [posttranslational modification] 1230340001955 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 1230340001956 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1230340001957 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340001958 motif II; other site 1230340001959 Predicted transcriptional regulator [Transcription]; Region: COG1959 1230340001960 Transcriptional regulator; Region: Rrf2; pfam02082 1230340001961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340001962 S-adenosylmethionine binding site [chemical binding]; other site 1230340001963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1230340001964 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1230340001965 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1230340001966 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1230340001967 active site 1230340001968 catalytic tetrad [active] 1230340001969 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1230340001970 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1230340001971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340001972 motif II; other site 1230340001973 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 1230340001974 catalytic residue [active] 1230340001975 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1230340001976 Sulfatase; Region: Sulfatase; pfam00884 1230340001977 amino acid transporter; Region: 2A0306; TIGR00909 1230340001978 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1230340001979 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1230340001980 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1230340001981 putative metal binding site [ion binding]; other site 1230340001982 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1230340001983 active site 1230340001984 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1230340001985 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1230340001986 Cl binding site [ion binding]; other site 1230340001987 oligomer interface [polypeptide binding]; other site 1230340001988 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1230340001989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340001990 DNA-binding site [nucleotide binding]; DNA binding site 1230340001991 Predicted membrane protein [Function unknown]; Region: COG1511 1230340001992 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1230340001993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340001994 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1230340001995 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340001996 DNA-binding site [nucleotide binding]; DNA binding site 1230340001997 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1230340001998 Predicted integral membrane protein [Function unknown]; Region: COG5523 1230340001999 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1230340002000 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1230340002001 active site 1230340002002 metal binding site [ion binding]; metal-binding site 1230340002003 AAA domain; Region: AAA_13; pfam13166 1230340002004 Predicted membrane protein [Function unknown]; Region: COG2322 1230340002005 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1230340002006 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1230340002007 minor groove reading motif; other site 1230340002008 helix-hairpin-helix signature motif; other site 1230340002009 substrate binding pocket [chemical binding]; other site 1230340002010 active site 1230340002011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340002012 non-specific DNA binding site [nucleotide binding]; other site 1230340002013 salt bridge; other site 1230340002014 sequence-specific DNA binding site [nucleotide binding]; other site 1230340002015 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1230340002016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1230340002017 Transposase; Region: HTH_Tnp_1; cl17663 1230340002018 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340002019 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340002020 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340002021 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1230340002022 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1230340002023 dimer interface [polypeptide binding]; other site 1230340002024 substrate binding site [chemical binding]; other site 1230340002025 ATP binding site [chemical binding]; other site 1230340002026 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1230340002027 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340002028 active site 1230340002029 motif I; other site 1230340002030 motif II; other site 1230340002031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340002032 maltose O-acetyltransferase; Provisional; Region: PRK10092 1230340002033 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1230340002034 active site 1230340002035 substrate binding site [chemical binding]; other site 1230340002036 trimer interface [polypeptide binding]; other site 1230340002037 CoA binding site [chemical binding]; other site 1230340002038 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1230340002039 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1230340002040 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1230340002041 Walker A/P-loop; other site 1230340002042 ATP binding site [chemical binding]; other site 1230340002043 Q-loop/lid; other site 1230340002044 ABC transporter signature motif; other site 1230340002045 Walker B; other site 1230340002046 D-loop; other site 1230340002047 H-loop/switch region; other site 1230340002048 inner membrane transport permease; Provisional; Region: PRK15066 1230340002049 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1230340002050 oxidoreductase; Provisional; Region: PRK07985 1230340002051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1230340002052 NAD(P) binding site [chemical binding]; other site 1230340002053 active site 1230340002054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1230340002055 Predicted membrane protein [Function unknown]; Region: COG3152 1230340002056 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 1230340002057 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 1230340002058 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 1230340002059 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 1230340002060 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 1230340002061 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1230340002062 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 1230340002063 FHIPEP family; Region: FHIPEP; pfam00771 1230340002064 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 1230340002065 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1230340002066 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 1230340002067 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1230340002068 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1230340002069 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1230340002070 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1230340002071 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 1230340002072 flagellar motor protein MotA; Validated; Region: PRK08124 1230340002073 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1230340002074 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1230340002075 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1230340002076 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1230340002077 ligand binding site [chemical binding]; other site 1230340002078 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1230340002079 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1230340002080 putative metal binding site; other site 1230340002081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1230340002082 binding surface 1230340002083 TPR motif; other site 1230340002084 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1230340002085 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1230340002086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340002087 active site 1230340002088 phosphorylation site [posttranslational modification] 1230340002089 intermolecular recognition site; other site 1230340002090 dimerization interface [polypeptide binding]; other site 1230340002091 flagellin; Provisional; Region: PRK12805 1230340002092 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1230340002093 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1230340002094 Response regulator receiver domain; Region: Response_reg; pfam00072 1230340002095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340002096 active site 1230340002097 phosphorylation site [posttranslational modification] 1230340002098 intermolecular recognition site; other site 1230340002099 dimerization interface [polypeptide binding]; other site 1230340002100 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1230340002101 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1230340002102 putative binding surface; other site 1230340002103 active site 1230340002104 P2 response regulator binding domain; Region: P2; pfam07194 1230340002105 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1230340002106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340002107 ATP binding site [chemical binding]; other site 1230340002108 Mg2+ binding site [ion binding]; other site 1230340002109 G-X-G motif; other site 1230340002110 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1230340002111 flagellar motor switch protein; Validated; Region: PRK06788 1230340002112 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1230340002113 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 1230340002114 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1230340002115 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 1230340002116 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1230340002117 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1230340002118 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1230340002119 flagellar motor switch protein; Validated; Region: PRK06789 1230340002120 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1230340002121 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1230340002122 flagellar motor switch protein; Reviewed; Region: PRK06782 1230340002123 CheC-like family; Region: CheC; pfam04509 1230340002124 CheC-like family; Region: CheC; pfam04509 1230340002125 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1230340002126 CheC-like family; Region: CheC; pfam04509 1230340002127 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1230340002128 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1230340002129 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 1230340002130 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1230340002131 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 1230340002132 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1230340002133 flagellar capping protein; Validated; Region: fliD; PRK06798 1230340002134 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1230340002135 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1230340002136 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 1230340002137 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 1230340002138 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 1230340002139 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1230340002140 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 1230340002141 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 1230340002142 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1230340002143 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1230340002144 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 1230340002145 FliG C-terminal domain; Region: FliG_C; pfam01706 1230340002146 flagellar assembly protein H; Validated; Region: fliH; PRK06800 1230340002147 Flagellar assembly protein FliH; Region: FliH; pfam02108 1230340002148 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 1230340002149 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1230340002150 Walker A motif; other site 1230340002151 ATP binding site [chemical binding]; other site 1230340002152 Walker B motif; other site 1230340002153 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1230340002154 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1230340002155 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1230340002156 catalytic residue [active] 1230340002157 Predicted transcriptional regulators [Transcription]; Region: COG1695 1230340002158 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1230340002159 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 1230340002160 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1230340002161 pyruvate oxidase; Provisional; Region: PRK08611 1230340002162 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1230340002163 PYR/PP interface [polypeptide binding]; other site 1230340002164 dimer interface [polypeptide binding]; other site 1230340002165 tetramer interface [polypeptide binding]; other site 1230340002166 TPP binding site [chemical binding]; other site 1230340002167 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1230340002168 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1230340002169 TPP-binding site [chemical binding]; other site 1230340002170 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1230340002171 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1230340002172 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1230340002173 dimerization interface [polypeptide binding]; other site 1230340002174 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1230340002175 dimer interface [polypeptide binding]; other site 1230340002176 putative CheW interface [polypeptide binding]; other site 1230340002177 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1230340002178 putative active site [active] 1230340002179 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1230340002180 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1230340002181 glutaminase active site [active] 1230340002182 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1230340002183 dimer interface [polypeptide binding]; other site 1230340002184 active site 1230340002185 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1230340002186 dimer interface [polypeptide binding]; other site 1230340002187 active site 1230340002188 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 1230340002189 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1230340002190 active site 1230340002191 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 1230340002192 GIY-YIG motif/motif A; other site 1230340002193 Leucine rich repeat; Region: LRR_8; pfam13855 1230340002194 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340002195 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340002196 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340002197 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1230340002198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340002199 non-specific DNA binding site [nucleotide binding]; other site 1230340002200 salt bridge; other site 1230340002201 sequence-specific DNA binding site [nucleotide binding]; other site 1230340002202 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340002203 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1230340002204 ligand binding site [chemical binding]; other site 1230340002205 flexible hinge region; other site 1230340002206 Predicted transcriptional regulators [Transcription]; Region: COG1725 1230340002207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340002208 DNA-binding site [nucleotide binding]; DNA binding site 1230340002209 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1230340002210 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340002211 Walker A/P-loop; other site 1230340002212 ATP binding site [chemical binding]; other site 1230340002213 Q-loop/lid; other site 1230340002214 ABC transporter signature motif; other site 1230340002215 Walker B; other site 1230340002216 D-loop; other site 1230340002217 H-loop/switch region; other site 1230340002218 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1230340002219 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1230340002220 Walker A/P-loop; other site 1230340002221 ATP binding site [chemical binding]; other site 1230340002222 Q-loop/lid; other site 1230340002223 ABC transporter signature motif; other site 1230340002224 Walker B; other site 1230340002225 D-loop; other site 1230340002226 H-loop/switch region; other site 1230340002227 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1230340002228 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1230340002229 FtsX-like permease family; Region: FtsX; pfam02687 1230340002230 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1230340002231 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340002232 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1230340002233 ligand binding site [chemical binding]; other site 1230340002234 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1230340002235 non-specific DNA interactions [nucleotide binding]; other site 1230340002236 DNA binding site [nucleotide binding] 1230340002237 sequence specific DNA binding site [nucleotide binding]; other site 1230340002238 putative cAMP binding site [chemical binding]; other site 1230340002239 SnoaL-like domain; Region: SnoaL_4; pfam13577 1230340002240 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1230340002241 active site 1230340002242 catalytic triad [active] 1230340002243 oxyanion hole [active] 1230340002244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340002245 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1230340002246 Walker A/P-loop; other site 1230340002247 ATP binding site [chemical binding]; other site 1230340002248 Q-loop/lid; other site 1230340002249 ABC transporter signature motif; other site 1230340002250 Walker B; other site 1230340002251 D-loop; other site 1230340002252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1230340002253 H-loop/switch region; other site 1230340002254 active site 1230340002255 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1230340002256 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1230340002257 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1230340002258 Zn binding site [ion binding]; other site 1230340002259 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1230340002260 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1230340002261 Zn binding site [ion binding]; other site 1230340002262 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1230340002263 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1230340002264 Zn binding site [ion binding]; other site 1230340002265 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1230340002266 Zn binding site [ion binding]; other site 1230340002267 Predicted esterase [General function prediction only]; Region: COG0400 1230340002268 putative hydrolase; Provisional; Region: PRK11460 1230340002269 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1230340002270 GTPases [General function prediction only]; Region: HflX; COG2262 1230340002271 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1230340002272 HflX GTPase family; Region: HflX; cd01878 1230340002273 G1 box; other site 1230340002274 GTP/Mg2+ binding site [chemical binding]; other site 1230340002275 Switch I region; other site 1230340002276 G2 box; other site 1230340002277 G3 box; other site 1230340002278 Switch II region; other site 1230340002279 G4 box; other site 1230340002280 G5 box; other site 1230340002281 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1230340002282 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1230340002283 putative active site [active] 1230340002284 putative metal binding site [ion binding]; other site 1230340002285 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1230340002286 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1230340002287 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1230340002288 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1230340002289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340002290 DNA-binding site [nucleotide binding]; DNA binding site 1230340002291 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1230340002292 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1230340002293 putative NADP binding site [chemical binding]; other site 1230340002294 putative dimer interface [polypeptide binding]; other site 1230340002295 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1230340002296 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1230340002297 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1230340002298 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1230340002299 nucleotide binding site [chemical binding]; other site 1230340002300 Predicted membrane protein [Function unknown]; Region: COG4811 1230340002301 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1230340002302 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1230340002303 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1230340002304 active site 1230340002305 phosphorylation site [posttranslational modification] 1230340002306 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1230340002307 active pocket/dimerization site; other site 1230340002308 active site 1230340002309 phosphorylation site [posttranslational modification] 1230340002310 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1230340002311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340002312 Walker A motif; other site 1230340002313 ATP binding site [chemical binding]; other site 1230340002314 Walker B motif; other site 1230340002315 arginine finger; other site 1230340002316 Transcriptional antiterminator [Transcription]; Region: COG3933 1230340002317 PRD domain; Region: PRD; pfam00874 1230340002318 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1230340002319 active pocket/dimerization site; other site 1230340002320 active site 1230340002321 phosphorylation site [posttranslational modification] 1230340002322 PRD domain; Region: PRD; pfam00874 1230340002323 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1230340002324 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1230340002325 Amino acid permease; Region: AA_permease; pfam00324 1230340002326 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1230340002327 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1230340002328 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1230340002329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1230340002330 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1230340002331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1230340002332 Leucine rich repeat; Region: LRR_8; pfam13855 1230340002333 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340002334 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340002335 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340002336 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340002337 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340002338 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340002339 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1230340002340 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1230340002341 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1230340002342 putative deacylase active site [active] 1230340002343 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1230340002344 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1230340002345 active site 1230340002346 catalytic triad [active] 1230340002347 dimer interface [polypeptide binding]; other site 1230340002348 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1230340002349 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1230340002350 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1230340002351 NAD binding site [chemical binding]; other site 1230340002352 substrate binding site [chemical binding]; other site 1230340002353 putative active site [active] 1230340002354 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1230340002355 EamA-like transporter family; Region: EamA; pfam00892 1230340002356 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1230340002357 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1230340002358 MarR family; Region: MarR_2; pfam12802 1230340002359 lysine transporter; Provisional; Region: PRK10836 1230340002360 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1230340002361 PAS domain; Region: PAS_9; pfam13426 1230340002362 putative active site [active] 1230340002363 heme pocket [chemical binding]; other site 1230340002364 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1230340002365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1230340002366 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1230340002367 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1230340002368 synthetase active site [active] 1230340002369 NTP binding site [chemical binding]; other site 1230340002370 metal binding site [ion binding]; metal-binding site 1230340002371 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1230340002372 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340002373 non-specific DNA binding site [nucleotide binding]; other site 1230340002374 salt bridge; other site 1230340002375 sequence-specific DNA binding site [nucleotide binding]; other site 1230340002376 Cupin domain; Region: Cupin_2; pfam07883 1230340002377 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1230340002378 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1230340002379 Walker A/P-loop; other site 1230340002380 ATP binding site [chemical binding]; other site 1230340002381 Q-loop/lid; other site 1230340002382 ABC transporter signature motif; other site 1230340002383 Walker B; other site 1230340002384 D-loop; other site 1230340002385 H-loop/switch region; other site 1230340002386 TOBE domain; Region: TOBE_2; pfam08402 1230340002387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1230340002388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340002389 putative PBP binding loops; other site 1230340002390 ABC-ATPase subunit interface; other site 1230340002391 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1230340002392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340002393 dimer interface [polypeptide binding]; other site 1230340002394 conserved gate region; other site 1230340002395 putative PBP binding loops; other site 1230340002396 ABC-ATPase subunit interface; other site 1230340002397 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1230340002398 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1230340002399 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 1230340002400 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1230340002401 active site 1230340002402 zinc binding site [ion binding]; other site 1230340002403 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1230340002404 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1230340002405 Zn2+ binding site [ion binding]; other site 1230340002406 Mg2+ binding site [ion binding]; other site 1230340002407 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1230340002408 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1230340002409 nucleotide binding site [chemical binding]; other site 1230340002410 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1230340002411 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1230340002412 FMN binding site [chemical binding]; other site 1230340002413 substrate binding site [chemical binding]; other site 1230340002414 putative catalytic residue [active] 1230340002415 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 1230340002416 LXG domain of WXG superfamily; Region: LXG; pfam04740 1230340002417 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1230340002418 dimer interface [polypeptide binding]; other site 1230340002419 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1230340002420 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1230340002421 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1230340002422 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1230340002423 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1230340002424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340002425 motif II; other site 1230340002426 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1230340002427 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1230340002428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340002429 Coenzyme A binding pocket [chemical binding]; other site 1230340002430 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1230340002431 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1230340002432 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1230340002433 DNA binding residues [nucleotide binding] 1230340002434 putative dimer interface [polypeptide binding]; other site 1230340002435 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1230340002436 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1230340002437 active site 1230340002438 catalytic tetrad [active] 1230340002439 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1230340002440 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1230340002441 homodimer interface [polypeptide binding]; other site 1230340002442 catalytic residues [active] 1230340002443 NAD binding site [chemical binding]; other site 1230340002444 substrate binding pocket [chemical binding]; other site 1230340002445 flexible flap; other site 1230340002446 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1230340002447 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1230340002448 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1230340002449 PhoU domain; Region: PhoU; pfam01895 1230340002450 PhoU domain; Region: PhoU; pfam01895 1230340002451 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1230340002452 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1230340002453 dimer interface [polypeptide binding]; other site 1230340002454 PYR/PP interface [polypeptide binding]; other site 1230340002455 TPP binding site [chemical binding]; other site 1230340002456 substrate binding site [chemical binding]; other site 1230340002457 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1230340002458 Domain of unknown function; Region: EKR; smart00890 1230340002459 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1230340002460 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1230340002461 TPP-binding site [chemical binding]; other site 1230340002462 dimer interface [polypeptide binding]; other site 1230340002463 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1230340002464 Predicted permeases [General function prediction only]; Region: COG0679 1230340002465 Helix-turn-helix domain; Region: HTH_28; pfam13518 1230340002466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340002467 non-specific DNA binding site [nucleotide binding]; other site 1230340002468 salt bridge; other site 1230340002469 sequence-specific DNA binding site [nucleotide binding]; other site 1230340002470 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1230340002471 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340002472 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340002473 Predicted membrane protein [Function unknown]; Region: COG3223 1230340002474 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1230340002475 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1230340002476 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1230340002477 Walker A/P-loop; other site 1230340002478 ATP binding site [chemical binding]; other site 1230340002479 Q-loop/lid; other site 1230340002480 ABC transporter signature motif; other site 1230340002481 Walker B; other site 1230340002482 D-loop; other site 1230340002483 H-loop/switch region; other site 1230340002484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340002485 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1230340002486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340002487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340002488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1230340002489 putative substrate translocation pore; other site 1230340002490 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1230340002491 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1230340002492 putative DNA binding site [nucleotide binding]; other site 1230340002493 putative Zn2+ binding site [ion binding]; other site 1230340002494 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1230340002495 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1230340002496 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1230340002497 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1230340002498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340002499 motif II; other site 1230340002500 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1230340002501 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340002502 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340002503 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340002504 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340002505 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340002506 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340002507 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340002508 Predicted membrane protein [Function unknown]; Region: COG3326 1230340002509 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1230340002510 substrate binding site [chemical binding]; other site 1230340002511 zinc-binding site [ion binding]; other site 1230340002512 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1230340002513 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1230340002514 GIY-YIG motif/motif A; other site 1230340002515 active site 1230340002516 catalytic site [active] 1230340002517 putative DNA binding site [nucleotide binding]; other site 1230340002518 metal binding site [ion binding]; metal-binding site 1230340002519 UvrB/uvrC motif; Region: UVR; pfam02151 1230340002520 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1230340002521 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1230340002522 substrate binding pocket [chemical binding]; other site 1230340002523 membrane-bound complex binding site; other site 1230340002524 hinge residues; other site 1230340002525 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1230340002526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340002527 dimer interface [polypeptide binding]; other site 1230340002528 conserved gate region; other site 1230340002529 putative PBP binding loops; other site 1230340002530 ABC-ATPase subunit interface; other site 1230340002531 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1230340002532 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1230340002533 Walker A/P-loop; other site 1230340002534 ATP binding site [chemical binding]; other site 1230340002535 Q-loop/lid; other site 1230340002536 ABC transporter signature motif; other site 1230340002537 Walker B; other site 1230340002538 D-loop; other site 1230340002539 H-loop/switch region; other site 1230340002540 amidase; Provisional; Region: PRK11910 1230340002541 Amidase; Region: Amidase; cl11426 1230340002542 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1230340002543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1230340002544 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1230340002545 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1230340002546 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1230340002547 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1230340002548 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1230340002549 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1230340002550 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1230340002551 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1230340002552 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1230340002553 Esterase/lipase [General function prediction only]; Region: COG1647 1230340002554 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1230340002555 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1230340002556 DNA binding site [nucleotide binding] 1230340002557 domain linker motif; other site 1230340002558 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 1230340002559 putative dimerization interface [polypeptide binding]; other site 1230340002560 putative ligand binding site [chemical binding]; other site 1230340002561 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1230340002562 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1230340002563 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1230340002564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340002565 dimer interface [polypeptide binding]; other site 1230340002566 conserved gate region; other site 1230340002567 putative PBP binding loops; other site 1230340002568 ABC-ATPase subunit interface; other site 1230340002569 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1230340002570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340002571 dimer interface [polypeptide binding]; other site 1230340002572 conserved gate region; other site 1230340002573 ABC-ATPase subunit interface; other site 1230340002574 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1230340002575 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1230340002576 Ca binding site [ion binding]; other site 1230340002577 active site 1230340002578 catalytic site [active] 1230340002579 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 1230340002580 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 1230340002581 active site 1230340002582 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1230340002583 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1230340002584 active site 1230340002585 substrate binding site [chemical binding]; other site 1230340002586 metal binding site [ion binding]; metal-binding site 1230340002587 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1230340002588 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1230340002589 ATP binding site [chemical binding]; other site 1230340002590 Mg++ binding site [ion binding]; other site 1230340002591 motif III; other site 1230340002592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1230340002593 nucleotide binding region [chemical binding]; other site 1230340002594 ATP-binding site [chemical binding]; other site 1230340002595 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1230340002596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 1230340002597 Predicted transcriptional regulators [Transcription]; Region: COG1733 1230340002598 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1230340002599 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1230340002600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340002601 putative substrate translocation pore; other site 1230340002602 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1230340002603 PRD domain; Region: PRD; pfam00874 1230340002604 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1230340002605 active site 1230340002606 P-loop; other site 1230340002607 phosphorylation site [posttranslational modification] 1230340002608 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340002609 active site 1230340002610 phosphorylation site [posttranslational modification] 1230340002611 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1230340002612 methionine cluster; other site 1230340002613 active site 1230340002614 phosphorylation site [posttranslational modification] 1230340002615 metal binding site [ion binding]; metal-binding site 1230340002616 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1230340002617 active site 1230340002618 P-loop; other site 1230340002619 phosphorylation site [posttranslational modification] 1230340002620 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1230340002621 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1230340002622 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1230340002623 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1230340002624 active site 1230340002625 trimer interface [polypeptide binding]; other site 1230340002626 allosteric site; other site 1230340002627 active site lid [active] 1230340002628 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1230340002629 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1230340002630 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1230340002631 active site 1230340002632 catalytic tetrad [active] 1230340002633 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1230340002634 Collagen binding domain; Region: Collagen_bind; pfam05737 1230340002635 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1230340002636 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1230340002637 Predicted membrane protein [Function unknown]; Region: COG3428 1230340002638 Bacterial PH domain; Region: DUF304; pfam03703 1230340002639 Bacterial PH domain; Region: DUF304; pfam03703 1230340002640 Bacterial PH domain; Region: DUF304; pfam03703 1230340002641 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1230340002642 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1230340002643 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1230340002644 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1230340002645 active site 1230340002646 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1230340002647 dimer interface [polypeptide binding]; other site 1230340002648 substrate binding site [chemical binding]; other site 1230340002649 catalytic residues [active] 1230340002650 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1230340002651 PemK-like protein; Region: PemK; pfam02452 1230340002652 Rsbr N terminal; Region: Rsbr_N; pfam08678 1230340002653 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1230340002654 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1230340002655 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1230340002656 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 1230340002657 ATP binding site [chemical binding]; other site 1230340002658 Mg2+ binding site [ion binding]; other site 1230340002659 G-X-G motif; other site 1230340002660 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1230340002661 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1230340002662 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1230340002663 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1230340002664 anti sigma factor interaction site; other site 1230340002665 regulatory phosphorylation site [posttranslational modification]; other site 1230340002666 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1230340002667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340002668 ATP binding site [chemical binding]; other site 1230340002669 Mg2+ binding site [ion binding]; other site 1230340002670 G-X-G motif; other site 1230340002671 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1230340002672 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1230340002673 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1230340002674 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1230340002675 DNA binding residues [nucleotide binding] 1230340002676 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1230340002677 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1230340002678 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1230340002679 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1230340002680 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1230340002681 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1230340002682 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1230340002683 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1230340002684 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1230340002685 RNA binding site [nucleotide binding]; other site 1230340002686 hypothetical protein; Provisional; Region: PRK04351 1230340002687 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1230340002688 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1230340002689 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1230340002690 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1230340002691 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1230340002692 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1230340002693 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1230340002694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340002695 DNA-binding site [nucleotide binding]; DNA binding site 1230340002696 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1230340002697 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1230340002698 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1230340002699 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 1230340002700 glutathione reductase; Validated; Region: PRK06116 1230340002701 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1230340002702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1230340002703 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1230340002704 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1230340002705 catalytic core [active] 1230340002706 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1230340002707 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1230340002708 Predicted transcriptional regulators [Transcription]; Region: COG1725 1230340002709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340002710 DNA-binding site [nucleotide binding]; DNA binding site 1230340002711 Predicted membrane protein [General function prediction only]; Region: COG4194 1230340002712 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1230340002713 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1230340002714 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1230340002715 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1230340002716 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1230340002717 tetramerization interface [polypeptide binding]; other site 1230340002718 NAD(P) binding site [chemical binding]; other site 1230340002719 catalytic residues [active] 1230340002720 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1230340002721 active site 1230340002722 P-loop; other site 1230340002723 phosphorylation site [posttranslational modification] 1230340002724 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1230340002725 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1230340002726 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1230340002727 methionine cluster; other site 1230340002728 active site 1230340002729 phosphorylation site [posttranslational modification] 1230340002730 metal binding site [ion binding]; metal-binding site 1230340002731 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1230340002732 beta-galactosidase; Region: BGL; TIGR03356 1230340002733 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1230340002734 Mga helix-turn-helix domain; Region: Mga; pfam05043 1230340002735 PRD domain; Region: PRD; pfam00874 1230340002736 PRD domain; Region: PRD; pfam00874 1230340002737 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340002738 active site 1230340002739 phosphorylation site [posttranslational modification] 1230340002740 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1230340002741 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1230340002742 ABC transporter; Region: ABC_tran_2; pfam12848 1230340002743 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1230340002744 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1230340002745 Predicted permeases [General function prediction only]; Region: COG0701 1230340002746 Predicted membrane protein [Function unknown]; Region: COG3689 1230340002747 pantothenate kinase; Provisional; Region: PRK05439 1230340002748 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1230340002749 ATP-binding site [chemical binding]; other site 1230340002750 CoA-binding site [chemical binding]; other site 1230340002751 Mg2+-binding site [ion binding]; other site 1230340002752 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1230340002753 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1230340002754 Walker A/P-loop; other site 1230340002755 ATP binding site [chemical binding]; other site 1230340002756 Q-loop/lid; other site 1230340002757 ABC transporter signature motif; other site 1230340002758 Walker B; other site 1230340002759 D-loop; other site 1230340002760 H-loop/switch region; other site 1230340002761 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1230340002762 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1230340002763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1230340002764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1230340002765 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1230340002766 Domain of unknown function (DUF373); Region: DUF373; cl12079 1230340002767 Sulfatase; Region: Sulfatase; pfam00884 1230340002768 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1230340002769 active site 1230340002770 DNA binding site [nucleotide binding] 1230340002771 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1230340002772 active site 1230340002773 catalytic site [active] 1230340002774 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1230340002775 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1230340002776 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1230340002777 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1230340002778 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1230340002779 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1230340002780 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1230340002781 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1230340002782 epoxyqueuosine reductase; Region: TIGR00276 1230340002783 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1230340002784 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1230340002785 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1230340002786 dimer interface [polypeptide binding]; other site 1230340002787 FMN binding site [chemical binding]; other site 1230340002788 NADPH bind site [chemical binding]; other site 1230340002789 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1230340002790 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1230340002791 active site 1230340002792 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1230340002793 HSP90 family protein; Provisional; Region: PRK14083 1230340002794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340002795 ATP binding site [chemical binding]; other site 1230340002796 Mg2+ binding site [ion binding]; other site 1230340002797 G-X-G motif; other site 1230340002798 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1230340002799 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1230340002800 dimerization interface [polypeptide binding]; other site 1230340002801 DPS ferroxidase diiron center [ion binding]; other site 1230340002802 ion pore; other site 1230340002803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1230340002804 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1230340002805 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1230340002806 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1230340002807 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 1230340002808 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1230340002809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340002810 putative substrate translocation pore; other site 1230340002811 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1230340002812 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340002813 DNA-binding site [nucleotide binding]; DNA binding site 1230340002814 FCD domain; Region: FCD; pfam07729 1230340002815 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1230340002816 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1230340002817 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 1230340002818 PGAP1-like protein; Region: PGAP1; pfam07819 1230340002819 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 1230340002820 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1230340002821 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1230340002822 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1230340002823 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1230340002824 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1230340002825 active site 1230340002826 dimer interface [polypeptide binding]; other site 1230340002827 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1230340002828 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1230340002829 active site 1230340002830 trimer interface [polypeptide binding]; other site 1230340002831 allosteric site; other site 1230340002832 active site lid [active] 1230340002833 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1230340002834 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1230340002835 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340002836 DNA-binding site [nucleotide binding]; DNA binding site 1230340002837 UTRA domain; Region: UTRA; pfam07702 1230340002838 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1230340002839 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1230340002840 putative catalytic motif [active] 1230340002841 substrate binding site [chemical binding]; other site 1230340002842 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1230340002843 Peptidase family U32; Region: Peptidase_U32; pfam01136 1230340002844 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1230340002845 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1230340002846 Peptidase family U32; Region: Peptidase_U32; pfam01136 1230340002847 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1230340002848 heat shock protein HtpX; Provisional; Region: PRK04897 1230340002849 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1230340002850 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1230340002851 catalytic residues [active] 1230340002852 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1230340002853 putative active site [active] 1230340002854 putative metal binding residues [ion binding]; other site 1230340002855 signature motif; other site 1230340002856 putative triphosphate binding site [ion binding]; other site 1230340002857 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1230340002858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1230340002859 binding surface 1230340002860 TPR motif; other site 1230340002861 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1230340002862 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1230340002863 synthetase active site [active] 1230340002864 NTP binding site [chemical binding]; other site 1230340002865 metal binding site [ion binding]; metal-binding site 1230340002866 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1230340002867 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1230340002868 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1230340002869 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1230340002870 active site 1230340002871 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1230340002872 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1230340002873 NAD binding site [chemical binding]; other site 1230340002874 homotetramer interface [polypeptide binding]; other site 1230340002875 homodimer interface [polypeptide binding]; other site 1230340002876 substrate binding site [chemical binding]; other site 1230340002877 active site 1230340002878 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1230340002879 DltD N-terminal region; Region: DltD_N; pfam04915 1230340002880 DltD central region; Region: DltD_M; pfam04918 1230340002881 DltD C-terminal region; Region: DltD_C; pfam04914 1230340002882 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1230340002883 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1230340002884 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1230340002885 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1230340002886 acyl-activating enzyme (AAE) consensus motif; other site 1230340002887 AMP binding site [chemical binding]; other site 1230340002888 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1230340002889 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1230340002890 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1230340002891 active site 1230340002892 dimer interface [polypeptide binding]; other site 1230340002893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340002894 Coenzyme A binding pocket [chemical binding]; other site 1230340002895 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1230340002896 Putative esterase; Region: Esterase; pfam00756 1230340002897 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1230340002898 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1230340002899 homodimer interface [polypeptide binding]; other site 1230340002900 substrate-cofactor binding pocket; other site 1230340002901 catalytic residue [active] 1230340002902 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1230340002903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340002904 Walker A/P-loop; other site 1230340002905 ATP binding site [chemical binding]; other site 1230340002906 Q-loop/lid; other site 1230340002907 ABC transporter signature motif; other site 1230340002908 Walker B; other site 1230340002909 D-loop; other site 1230340002910 H-loop/switch region; other site 1230340002911 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1230340002912 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1230340002913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340002914 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1230340002915 putative substrate translocation pore; other site 1230340002916 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1230340002917 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1230340002918 putative oligomer interface [polypeptide binding]; other site 1230340002919 putative active site [active] 1230340002920 metal binding site [ion binding]; metal-binding site 1230340002921 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1230340002922 catalytic residues [active] 1230340002923 dimer interface [polypeptide binding]; other site 1230340002924 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1230340002925 LytTr DNA-binding domain; Region: LytTR; pfam04397 1230340002926 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1230340002927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340002928 Walker A/P-loop; other site 1230340002929 ATP binding site [chemical binding]; other site 1230340002930 Q-loop/lid; other site 1230340002931 ABC transporter signature motif; other site 1230340002932 Walker B; other site 1230340002933 D-loop; other site 1230340002934 H-loop/switch region; other site 1230340002935 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 1230340002936 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1230340002937 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1230340002938 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1230340002939 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1230340002940 G1 box; other site 1230340002941 putative GEF interaction site [polypeptide binding]; other site 1230340002942 GTP/Mg2+ binding site [chemical binding]; other site 1230340002943 Switch I region; other site 1230340002944 G2 box; other site 1230340002945 G3 box; other site 1230340002946 Switch II region; other site 1230340002947 G4 box; other site 1230340002948 G5 box; other site 1230340002949 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1230340002950 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1230340002951 MarR family; Region: MarR_2; cl17246 1230340002952 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1230340002953 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1230340002954 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1230340002955 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1230340002956 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1230340002957 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1230340002958 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1230340002959 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1230340002960 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1230340002961 DNA binding site [nucleotide binding] 1230340002962 active site 1230340002963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340002964 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1230340002965 Walker A motif; other site 1230340002966 ATP binding site [chemical binding]; other site 1230340002967 Walker B motif; other site 1230340002968 arginine finger; other site 1230340002969 UvrB/uvrC motif; Region: UVR; pfam02151 1230340002970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340002971 Walker A motif; other site 1230340002972 ATP binding site [chemical binding]; other site 1230340002973 Walker B motif; other site 1230340002974 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1230340002975 CAAX protease self-immunity; Region: Abi; pfam02517 1230340002976 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1230340002977 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1230340002978 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1230340002979 nucleotide binding site [chemical binding]; other site 1230340002980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 1230340002981 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1230340002982 dimerization domain swap beta strand [polypeptide binding]; other site 1230340002983 regulatory protein interface [polypeptide binding]; other site 1230340002984 active site 1230340002985 regulatory phosphorylation site [posttranslational modification]; other site 1230340002986 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1230340002987 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1230340002988 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1230340002989 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1230340002990 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1230340002991 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1230340002992 putative active site [active] 1230340002993 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1230340002994 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1230340002995 aminotransferase A; Validated; Region: PRK07683 1230340002996 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1230340002997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340002998 homodimer interface [polypeptide binding]; other site 1230340002999 catalytic residue [active] 1230340003000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 1230340003001 FOG: CBS domain [General function prediction only]; Region: COG0517 1230340003002 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1230340003003 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1230340003004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1230340003005 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1230340003006 dimerization interface [polypeptide binding]; other site 1230340003007 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1230340003008 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1230340003009 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1230340003010 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1230340003011 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1230340003012 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1230340003013 metal binding site [ion binding]; metal-binding site 1230340003014 putative dimer interface [polypeptide binding]; other site 1230340003015 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1230340003016 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 1230340003017 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1230340003018 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1230340003019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340003020 Walker A/P-loop; other site 1230340003021 ATP binding site [chemical binding]; other site 1230340003022 Q-loop/lid; other site 1230340003023 ABC transporter signature motif; other site 1230340003024 Walker B; other site 1230340003025 D-loop; other site 1230340003026 H-loop/switch region; other site 1230340003027 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1230340003028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340003029 dimer interface [polypeptide binding]; other site 1230340003030 conserved gate region; other site 1230340003031 putative PBP binding loops; other site 1230340003032 ABC-ATPase subunit interface; other site 1230340003033 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1230340003034 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1230340003035 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1230340003036 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1230340003037 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1230340003038 HPr interaction site; other site 1230340003039 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1230340003040 active site 1230340003041 phosphorylation site [posttranslational modification] 1230340003042 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1230340003043 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1230340003044 S1 domain; Region: S1_2; pfam13509 1230340003045 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1230340003046 RNA binding site [nucleotide binding]; other site 1230340003047 Predicted membrane protein [Function unknown]; Region: COG4758 1230340003048 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1230340003049 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1230340003050 Histidine kinase; Region: HisKA_3; pfam07730 1230340003051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340003052 ATP binding site [chemical binding]; other site 1230340003053 Mg2+ binding site [ion binding]; other site 1230340003054 G-X-G motif; other site 1230340003055 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1230340003056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340003057 active site 1230340003058 phosphorylation site [posttranslational modification] 1230340003059 intermolecular recognition site; other site 1230340003060 dimerization interface [polypeptide binding]; other site 1230340003061 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1230340003062 DNA binding residues [nucleotide binding] 1230340003063 dimerization interface [polypeptide binding]; other site 1230340003064 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1230340003065 TrkA-N domain; Region: TrkA_N; pfam02254 1230340003066 TrkA-C domain; Region: TrkA_C; pfam02080 1230340003067 Predicted membrane protein [Function unknown]; Region: COG1289 1230340003068 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1230340003069 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1230340003070 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1230340003071 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1230340003072 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1230340003073 hypothetical protein; Provisional; Region: PRK13667 1230340003074 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1230340003075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340003076 active site 1230340003077 motif I; other site 1230340003078 motif II; other site 1230340003079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340003080 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1230340003081 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1230340003082 DNA binding site [nucleotide binding] 1230340003083 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1230340003084 ligand binding site [chemical binding]; other site 1230340003085 dimerization interface [polypeptide binding]; other site 1230340003086 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 1230340003087 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1230340003088 trimer interface [polypeptide binding]; other site 1230340003089 substrate binding site [chemical binding]; other site 1230340003090 Mn binding site [ion binding]; other site 1230340003091 transketolase; Reviewed; Region: PRK05899 1230340003092 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1230340003093 TPP-binding site [chemical binding]; other site 1230340003094 dimer interface [polypeptide binding]; other site 1230340003095 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1230340003096 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1230340003097 PYR/PP interface [polypeptide binding]; other site 1230340003098 dimer interface [polypeptide binding]; other site 1230340003099 TPP binding site [chemical binding]; other site 1230340003100 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1230340003101 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1230340003102 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1230340003103 nucleotide binding site [chemical binding]; other site 1230340003104 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1230340003105 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1230340003106 active site turn [active] 1230340003107 phosphorylation site [posttranslational modification] 1230340003108 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1230340003109 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1230340003110 HPr interaction site; other site 1230340003111 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1230340003112 active site 1230340003113 phosphorylation site [posttranslational modification] 1230340003114 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1230340003115 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 1230340003116 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 1230340003117 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1230340003118 Walker A/P-loop; other site 1230340003119 ATP binding site [chemical binding]; other site 1230340003120 Q-loop/lid; other site 1230340003121 ABC transporter signature motif; other site 1230340003122 Walker B; other site 1230340003123 D-loop; other site 1230340003124 H-loop/switch region; other site 1230340003125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340003126 dimer interface [polypeptide binding]; other site 1230340003127 conserved gate region; other site 1230340003128 putative PBP binding loops; other site 1230340003129 ABC-ATPase subunit interface; other site 1230340003130 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1230340003131 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1230340003132 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1230340003133 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1230340003134 dimer interface [polypeptide binding]; other site 1230340003135 putative functional site; other site 1230340003136 putative MPT binding site; other site 1230340003137 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1230340003138 Walker A motif; other site 1230340003139 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1230340003140 MoaE homodimer interface [polypeptide binding]; other site 1230340003141 MoaD interaction [polypeptide binding]; other site 1230340003142 active site residues [active] 1230340003143 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1230340003144 MoaE interaction surface [polypeptide binding]; other site 1230340003145 MoeB interaction surface [polypeptide binding]; other site 1230340003146 thiocarboxylated glycine; other site 1230340003147 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1230340003148 trimer interface [polypeptide binding]; other site 1230340003149 dimer interface [polypeptide binding]; other site 1230340003150 putative active site [active] 1230340003151 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1230340003152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1230340003153 FeS/SAM binding site; other site 1230340003154 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1230340003155 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1230340003156 MPT binding site; other site 1230340003157 trimer interface [polypeptide binding]; other site 1230340003158 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1230340003159 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1230340003160 ATP binding site [chemical binding]; other site 1230340003161 substrate interface [chemical binding]; other site 1230340003162 Flavin Reductases; Region: FlaRed; cl00801 1230340003163 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1230340003164 active site 1230340003165 catalytic residues [active] 1230340003166 metal binding site [ion binding]; metal-binding site 1230340003167 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1230340003168 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1230340003169 TPP-binding site [chemical binding]; other site 1230340003170 tetramer interface [polypeptide binding]; other site 1230340003171 heterodimer interface [polypeptide binding]; other site 1230340003172 phosphorylation loop region [posttranslational modification] 1230340003173 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1230340003174 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1230340003175 alpha subunit interface [polypeptide binding]; other site 1230340003176 TPP binding site [chemical binding]; other site 1230340003177 heterodimer interface [polypeptide binding]; other site 1230340003178 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1230340003179 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1230340003180 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1230340003181 E3 interaction surface; other site 1230340003182 lipoyl attachment site [posttranslational modification]; other site 1230340003183 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1230340003184 E3 interaction surface; other site 1230340003185 lipoyl attachment site [posttranslational modification]; other site 1230340003186 e3 binding domain; Region: E3_binding; pfam02817 1230340003187 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1230340003188 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1230340003189 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1230340003190 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 1230340003191 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1230340003192 NAD(P) binding site [chemical binding]; other site 1230340003193 LDH/MDH dimer interface [polypeptide binding]; other site 1230340003194 substrate binding site [chemical binding]; other site 1230340003195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476 1230340003196 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1230340003197 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1230340003198 catalytic residues [active] 1230340003199 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1230340003200 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1230340003201 Cl binding site [ion binding]; other site 1230340003202 oligomer interface [polypeptide binding]; other site 1230340003203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1230340003204 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1230340003205 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1230340003206 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1230340003207 active site 1230340003208 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1230340003209 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1230340003210 G1 box; other site 1230340003211 putative GEF interaction site [polypeptide binding]; other site 1230340003212 GTP/Mg2+ binding site [chemical binding]; other site 1230340003213 Switch I region; other site 1230340003214 G2 box; other site 1230340003215 G3 box; other site 1230340003216 Switch II region; other site 1230340003217 G4 box; other site 1230340003218 G5 box; other site 1230340003219 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1230340003220 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1230340003221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 1230340003222 hypothetical protein; Provisional; Region: PRK13666 1230340003223 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1230340003224 pyruvate carboxylase; Reviewed; Region: PRK12999 1230340003225 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1230340003226 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1230340003227 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1230340003228 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1230340003229 active site 1230340003230 catalytic residues [active] 1230340003231 metal binding site [ion binding]; metal-binding site 1230340003232 homodimer binding site [polypeptide binding]; other site 1230340003233 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1230340003234 carboxyltransferase (CT) interaction site; other site 1230340003235 biotinylation site [posttranslational modification]; other site 1230340003236 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1230340003237 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1230340003238 putative binding site residues; other site 1230340003239 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1230340003240 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1230340003241 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1230340003242 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1230340003243 Walker A/P-loop; other site 1230340003244 ATP binding site [chemical binding]; other site 1230340003245 Q-loop/lid; other site 1230340003246 ABC transporter signature motif; other site 1230340003247 Walker B; other site 1230340003248 D-loop; other site 1230340003249 H-loop/switch region; other site 1230340003250 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1230340003251 SH3-like domain; Region: SH3_8; pfam13457 1230340003252 SH3-like domain; Region: SH3_8; pfam13457 1230340003253 SH3-like domain; Region: SH3_8; pfam13457 1230340003254 SH3-like domain; Region: SH3_8; pfam13457 1230340003255 SH3-like domain; Region: SH3_8; pfam13457 1230340003256 SH3-like domain; Region: SH3_8; pfam13457 1230340003257 SH3-like domain; Region: SH3_8; pfam13457 1230340003258 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1230340003259 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1230340003260 Ligand binding site; other site 1230340003261 Putative Catalytic site; other site 1230340003262 DXD motif; other site 1230340003263 conserved hypothetical integral membrane protein; Region: TIGR03766 1230340003264 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1230340003265 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1230340003266 active site 1230340003267 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1230340003268 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1230340003269 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1230340003270 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1230340003271 active site 1230340003272 tetramer interface; other site 1230340003273 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1230340003274 substrate binding site; other site 1230340003275 dimer interface; other site 1230340003276 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1230340003277 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1230340003278 putative NAD(P) binding site [chemical binding]; other site 1230340003279 putative catalytic Zn binding site [ion binding]; other site 1230340003280 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1230340003281 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1230340003282 active site 1230340003283 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1230340003284 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1230340003285 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1230340003286 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1230340003287 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1230340003288 active site 1230340003289 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1230340003290 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1230340003291 active site 1230340003292 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1230340003293 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1230340003294 homodimer interface [polypeptide binding]; other site 1230340003295 NAD binding pocket [chemical binding]; other site 1230340003296 ATP binding pocket [chemical binding]; other site 1230340003297 Mg binding site [ion binding]; other site 1230340003298 active-site loop [active] 1230340003299 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1230340003300 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 1230340003301 active site 1230340003302 P-loop; other site 1230340003303 phosphorylation site [posttranslational modification] 1230340003304 GMP synthase; Reviewed; Region: guaA; PRK00074 1230340003305 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1230340003306 AMP/PPi binding site [chemical binding]; other site 1230340003307 candidate oxyanion hole; other site 1230340003308 catalytic triad [active] 1230340003309 potential glutamine specificity residues [chemical binding]; other site 1230340003310 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1230340003311 ATP Binding subdomain [chemical binding]; other site 1230340003312 Dimerization subdomain; other site 1230340003313 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1230340003314 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1230340003315 active site 1230340003316 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1230340003317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340003318 Walker A/P-loop; other site 1230340003319 ATP binding site [chemical binding]; other site 1230340003320 Q-loop/lid; other site 1230340003321 ABC transporter signature motif; other site 1230340003322 Walker B; other site 1230340003323 D-loop; other site 1230340003324 H-loop/switch region; other site 1230340003325 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1230340003326 putative FMN binding site [chemical binding]; other site 1230340003327 NADPH bind site [chemical binding]; other site 1230340003328 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 1230340003329 YcaO-like family; Region: YcaO; pfam02624 1230340003330 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1230340003331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1230340003332 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1230340003333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1230340003334 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1230340003335 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1230340003336 active site 1230340003337 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 1230340003338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1230340003339 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1230340003340 MepB protein; Region: MepB; cl01985 1230340003341 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1230340003342 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1230340003343 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1230340003344 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1230340003345 DNA binding residues [nucleotide binding] 1230340003346 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1230340003347 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1230340003348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340003349 Walker A/P-loop; other site 1230340003350 ATP binding site [chemical binding]; other site 1230340003351 Q-loop/lid; other site 1230340003352 ABC transporter signature motif; other site 1230340003353 Walker B; other site 1230340003354 D-loop; other site 1230340003355 H-loop/switch region; other site 1230340003356 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1230340003357 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1230340003358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340003359 Walker A/P-loop; other site 1230340003360 ATP binding site [chemical binding]; other site 1230340003361 Q-loop/lid; other site 1230340003362 ABC transporter signature motif; other site 1230340003363 Walker B; other site 1230340003364 D-loop; other site 1230340003365 H-loop/switch region; other site 1230340003366 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1230340003367 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1230340003368 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1230340003369 DNA binding residues [nucleotide binding] 1230340003370 putative dimer interface [polypeptide binding]; other site 1230340003371 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1230340003372 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1230340003373 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1230340003374 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1230340003375 LRR adjacent; Region: LRR_adjacent; pfam08191 1230340003376 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340003377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 1230340003378 Clp protease; Region: CLP_protease; pfam00574 1230340003379 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1230340003380 oligomer interface [polypeptide binding]; other site 1230340003381 active site residues [active] 1230340003382 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1230340003383 dimer interface [polypeptide binding]; other site 1230340003384 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1230340003385 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1230340003386 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1230340003387 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1230340003388 SLBB domain; Region: SLBB; pfam10531 1230340003389 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1230340003390 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 1230340003391 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1230340003392 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 1230340003393 putative hexamer interface [polypeptide binding]; other site 1230340003394 putative hexagonal pore; other site 1230340003395 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 1230340003396 putative hexamer interface [polypeptide binding]; other site 1230340003397 putative hexagonal pore; other site 1230340003398 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1230340003399 putative hexamer interface [polypeptide binding]; other site 1230340003400 putative hexagonal pore; other site 1230340003401 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1230340003402 G1 box; other site 1230340003403 GTP/Mg2+ binding site [chemical binding]; other site 1230340003404 G2 box; other site 1230340003405 Switch I region; other site 1230340003406 G3 box; other site 1230340003407 Switch II region; other site 1230340003408 G4 box; other site 1230340003409 G5 box; other site 1230340003410 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1230340003411 homotrimer interface [polypeptide binding]; other site 1230340003412 Walker A motif; other site 1230340003413 GTP binding site [chemical binding]; other site 1230340003414 Walker B motif; other site 1230340003415 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 1230340003416 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1230340003417 catalytic core [active] 1230340003418 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1230340003419 Sensory domain found in PocR; Region: PocR; pfam10114 1230340003420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1230340003421 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1230340003422 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1230340003423 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1230340003424 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1230340003425 Hexamer interface [polypeptide binding]; other site 1230340003426 Hexagonal pore residue; other site 1230340003427 propanediol utilization protein PduB; Provisional; Region: PRK15415 1230340003428 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 1230340003429 putative hexamer interface [polypeptide binding]; other site 1230340003430 putative hexagonal pore; other site 1230340003431 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 1230340003432 putative hexamer interface [polypeptide binding]; other site 1230340003433 putative hexagonal pore; other site 1230340003434 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 1230340003435 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 1230340003436 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 1230340003437 alpha-beta subunit interface [polypeptide binding]; other site 1230340003438 alpha-gamma subunit interface [polypeptide binding]; other site 1230340003439 active site 1230340003440 substrate and K+ binding site; other site 1230340003441 K+ binding site [ion binding]; other site 1230340003442 cobalamin binding site [chemical binding]; other site 1230340003443 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 1230340003444 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 1230340003445 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 1230340003446 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 1230340003447 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1230340003448 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 1230340003449 putative hexamer interface [polypeptide binding]; other site 1230340003450 putative hexagonal pore; other site 1230340003451 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1230340003452 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1230340003453 Hexamer interface [polypeptide binding]; other site 1230340003454 Hexagonal pore residue; other site 1230340003455 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 1230340003456 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1230340003457 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1230340003458 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 1230340003459 Cell division protein FtsA; Region: FtsA; cl17206 1230340003460 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1230340003461 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 1230340003462 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1230340003463 Hexamer/Pentamer interface [polypeptide binding]; other site 1230340003464 central pore; other site 1230340003465 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1230340003466 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1230340003467 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1230340003468 putative catalytic cysteine [active] 1230340003469 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1230340003470 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1230340003471 putative active site [active] 1230340003472 metal binding site [ion binding]; metal-binding site 1230340003473 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1230340003474 amphipathic channel; other site 1230340003475 Asn-Pro-Ala signature motifs; other site 1230340003476 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1230340003477 propionate/acetate kinase; Provisional; Region: PRK12379 1230340003478 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 1230340003479 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1230340003480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340003481 homodimer interface [polypeptide binding]; other site 1230340003482 catalytic residue [active] 1230340003483 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1230340003484 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1230340003485 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1230340003486 putative active site [active] 1230340003487 metal binding site [ion binding]; metal-binding site 1230340003488 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1230340003489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340003490 active site 1230340003491 phosphorylation site [posttranslational modification] 1230340003492 intermolecular recognition site; other site 1230340003493 dimerization interface [polypeptide binding]; other site 1230340003494 ANTAR domain; Region: ANTAR; pfam03861 1230340003495 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1230340003496 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1230340003497 Histidine kinase; Region: HisKA_2; pfam07568 1230340003498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340003499 ATP binding site [chemical binding]; other site 1230340003500 Mg2+ binding site [ion binding]; other site 1230340003501 G-X-G motif; other site 1230340003502 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 1230340003503 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 1230340003504 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1230340003505 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 1230340003506 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 1230340003507 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 1230340003508 putative hexamer interface [polypeptide binding]; other site 1230340003509 putative hexagonal pore; other site 1230340003510 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 1230340003511 putative hexamer interface [polypeptide binding]; other site 1230340003512 putative hexagonal pore; other site 1230340003513 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1230340003514 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1230340003515 Hexamer interface [polypeptide binding]; other site 1230340003516 Hexagonal pore residue; other site 1230340003517 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1230340003518 putative catalytic cysteine [active] 1230340003519 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1230340003520 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1230340003521 Hexamer interface [polypeptide binding]; other site 1230340003522 Putative hexagonal pore residue; other site 1230340003523 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 1230340003524 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 1230340003525 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1230340003526 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1230340003527 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 1230340003528 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1230340003529 Hexamer/Pentamer interface [polypeptide binding]; other site 1230340003530 central pore; other site 1230340003531 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 1230340003532 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 1230340003533 putative hexamer interface [polypeptide binding]; other site 1230340003534 putative hexagonal pore; other site 1230340003535 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 1230340003536 putative hexamer interface [polypeptide binding]; other site 1230340003537 putative hexagonal pore; other site 1230340003538 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 1230340003539 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1230340003540 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 1230340003541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1230340003542 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1230340003543 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1230340003544 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1230340003545 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1230340003546 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1230340003547 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1230340003548 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1230340003549 catalytic triad [active] 1230340003550 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1230340003551 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 1230340003552 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1230340003553 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 1230340003554 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1230340003555 active site 1230340003556 putative homodimer interface [polypeptide binding]; other site 1230340003557 SAM binding site [chemical binding]; other site 1230340003558 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 1230340003559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340003560 S-adenosylmethionine binding site [chemical binding]; other site 1230340003561 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1230340003562 active site 1230340003563 SAM binding site [chemical binding]; other site 1230340003564 homodimer interface [polypeptide binding]; other site 1230340003565 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1230340003566 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1230340003567 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1230340003568 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1230340003569 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1230340003570 homodimer interface [polypeptide binding]; other site 1230340003571 active site 1230340003572 SAM binding site [chemical binding]; other site 1230340003573 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1230340003574 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1230340003575 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1230340003576 active site 1230340003577 SAM binding site [chemical binding]; other site 1230340003578 homodimer interface [polypeptide binding]; other site 1230340003579 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1230340003580 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1230340003581 active site 1230340003582 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 1230340003583 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 1230340003584 active site 1230340003585 C-terminal domain interface [polypeptide binding]; other site 1230340003586 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 1230340003587 active site 1230340003588 N-terminal domain interface [polypeptide binding]; other site 1230340003589 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1230340003590 active site 1230340003591 SAM binding site [chemical binding]; other site 1230340003592 homodimer interface [polypeptide binding]; other site 1230340003593 cobalt transport protein CbiM; Validated; Region: PRK08319 1230340003594 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1230340003595 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 1230340003596 cobalt transport protein CbiQ; Provisional; Region: PRK15485 1230340003597 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 1230340003598 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1230340003599 Walker A/P-loop; other site 1230340003600 ATP binding site [chemical binding]; other site 1230340003601 Q-loop/lid; other site 1230340003602 ABC transporter signature motif; other site 1230340003603 Walker B; other site 1230340003604 D-loop; other site 1230340003605 H-loop/switch region; other site 1230340003606 cobyric acid synthase; Provisional; Region: PRK00784 1230340003607 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1230340003608 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1230340003609 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1230340003610 catalytic triad [active] 1230340003611 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1230340003612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1230340003613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1230340003614 AAA domain; Region: AAA_17; cl17253 1230340003615 Predicted transcriptional regulators [Transcription]; Region: COG1695 1230340003616 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1230340003617 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1230340003618 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1230340003619 SH3-like domain; Region: SH3_8; pfam13457 1230340003620 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1230340003621 SH3-like domain; Region: SH3_8; pfam13457 1230340003622 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1230340003623 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1230340003624 oligomer interface [polypeptide binding]; other site 1230340003625 active site 1230340003626 metal binding site [ion binding]; metal-binding site 1230340003627 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1230340003628 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1230340003629 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1230340003630 Predicted transcriptional regulators [Transcription]; Region: COG1733 1230340003631 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1230340003632 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1230340003633 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1230340003634 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1230340003635 dimer interface [polypeptide binding]; other site 1230340003636 motif 1; other site 1230340003637 active site 1230340003638 motif 2; other site 1230340003639 motif 3; other site 1230340003640 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1230340003641 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1230340003642 putative tRNA-binding site [nucleotide binding]; other site 1230340003643 B3/4 domain; Region: B3_4; pfam03483 1230340003644 tRNA synthetase B5 domain; Region: B5; smart00874 1230340003645 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1230340003646 dimer interface [polypeptide binding]; other site 1230340003647 motif 1; other site 1230340003648 motif 3; other site 1230340003649 motif 2; other site 1230340003650 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1230340003651 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1230340003652 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1230340003653 Walker A/P-loop; other site 1230340003654 ATP binding site [chemical binding]; other site 1230340003655 Q-loop/lid; other site 1230340003656 ABC transporter signature motif; other site 1230340003657 Walker B; other site 1230340003658 D-loop; other site 1230340003659 H-loop/switch region; other site 1230340003660 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1230340003661 FtsX-like permease family; Region: FtsX; pfam02687 1230340003662 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1230340003663 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1230340003664 FtsX-like permease family; Region: FtsX; pfam02687 1230340003665 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1230340003666 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1230340003667 putative DNA binding site [nucleotide binding]; other site 1230340003668 putative Zn2+ binding site [ion binding]; other site 1230340003669 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1230340003670 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1230340003671 ligand binding site [chemical binding]; other site 1230340003672 active site 1230340003673 UGI interface [polypeptide binding]; other site 1230340003674 catalytic site [active] 1230340003675 ribonuclease HIII; Provisional; Region: PRK00996 1230340003676 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1230340003677 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1230340003678 RNA/DNA hybrid binding site [nucleotide binding]; other site 1230340003679 active site 1230340003680 Cell division protein ZapA; Region: ZapA; cl01146 1230340003681 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1230340003682 Colicin V production protein; Region: Colicin_V; pfam02674 1230340003683 hypothetical protein; Provisional; Region: PRK08609 1230340003684 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1230340003685 active site 1230340003686 primer binding site [nucleotide binding]; other site 1230340003687 NTP binding site [chemical binding]; other site 1230340003688 metal binding triad [ion binding]; metal-binding site 1230340003689 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1230340003690 active site 1230340003691 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1230340003692 MutS domain III; Region: MutS_III; pfam05192 1230340003693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340003694 Walker A/P-loop; other site 1230340003695 ATP binding site [chemical binding]; other site 1230340003696 Q-loop/lid; other site 1230340003697 ABC transporter signature motif; other site 1230340003698 Walker B; other site 1230340003699 D-loop; other site 1230340003700 H-loop/switch region; other site 1230340003701 Smr domain; Region: Smr; pfam01713 1230340003702 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1230340003703 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1230340003704 catalytic residues [active] 1230340003705 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1230340003706 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1230340003707 GIY-YIG motif/motif A; other site 1230340003708 active site 1230340003709 catalytic site [active] 1230340003710 putative DNA binding site [nucleotide binding]; other site 1230340003711 metal binding site [ion binding]; metal-binding site 1230340003712 UvrB/uvrC motif; Region: UVR; pfam02151 1230340003713 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1230340003714 aspartate kinase; Reviewed; Region: PRK06635 1230340003715 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1230340003716 putative Mg ion binding site [ion binding]; other site 1230340003717 putative aspartate binding site [chemical binding]; other site 1230340003718 putative catalytic residues [active] 1230340003719 putative nucleotide binding site [chemical binding]; other site 1230340003720 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1230340003721 putative allosteric regulatory site; other site 1230340003722 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1230340003723 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1230340003724 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 1230340003725 ribonuclease PH; Reviewed; Region: rph; PRK00173 1230340003726 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1230340003727 hexamer interface [polypeptide binding]; other site 1230340003728 active site 1230340003729 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1230340003730 active site 1230340003731 dimerization interface [polypeptide binding]; other site 1230340003732 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1230340003733 active site 1230340003734 metal binding site [ion binding]; metal-binding site 1230340003735 homotetramer interface [polypeptide binding]; other site 1230340003736 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1230340003737 LRR adjacent; Region: LRR_adjacent; pfam08191 1230340003738 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340003739 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340003740 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340003741 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340003742 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340003743 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1230340003744 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1230340003745 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 1230340003746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1230340003747 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1230340003748 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1230340003749 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1230340003750 dimer interface [polypeptide binding]; other site 1230340003751 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1230340003752 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1230340003753 catalytic core [active] 1230340003754 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1230340003755 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1230340003756 ATP binding site [chemical binding]; other site 1230340003757 Mg++ binding site [ion binding]; other site 1230340003758 motif III; other site 1230340003759 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1230340003760 nucleotide binding region [chemical binding]; other site 1230340003761 ATP-binding site [chemical binding]; other site 1230340003762 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1230340003763 RNA binding site [nucleotide binding]; other site 1230340003764 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 1230340003765 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1230340003766 putative active site [active] 1230340003767 nucleotide binding site [chemical binding]; other site 1230340003768 nudix motif; other site 1230340003769 putative metal binding site [ion binding]; other site 1230340003770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340003771 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1230340003772 putative substrate translocation pore; other site 1230340003773 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340003774 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1230340003775 ligand binding site [chemical binding]; other site 1230340003776 flexible hinge region; other site 1230340003777 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1230340003778 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1230340003779 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1230340003780 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1230340003781 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1230340003782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340003783 DNA-binding site [nucleotide binding]; DNA binding site 1230340003784 UTRA domain; Region: UTRA; pfam07702 1230340003785 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1230340003786 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1230340003787 Ca binding site [ion binding]; other site 1230340003788 active site 1230340003789 catalytic site [active] 1230340003790 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1230340003791 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1230340003792 active site turn [active] 1230340003793 phosphorylation site [posttranslational modification] 1230340003794 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1230340003795 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 1230340003796 nudix motif; other site 1230340003797 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1230340003798 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1230340003799 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1230340003800 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1230340003801 putative catalytic cysteine [active] 1230340003802 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 1230340003803 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1230340003804 nucleotide binding site [chemical binding]; other site 1230340003805 homotetrameric interface [polypeptide binding]; other site 1230340003806 putative phosphate binding site [ion binding]; other site 1230340003807 putative allosteric binding site; other site 1230340003808 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 1230340003809 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1230340003810 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1230340003811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340003812 non-specific DNA binding site [nucleotide binding]; other site 1230340003813 salt bridge; other site 1230340003814 sequence-specific DNA binding site [nucleotide binding]; other site 1230340003815 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340003816 non-specific DNA binding site [nucleotide binding]; other site 1230340003817 salt bridge; other site 1230340003818 sequence-specific DNA binding site [nucleotide binding]; other site 1230340003819 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1230340003820 active site 1230340003821 trigger factor; Provisional; Region: tig; PRK01490 1230340003822 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1230340003823 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1230340003824 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1230340003825 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1230340003826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340003827 Walker A motif; other site 1230340003828 ATP binding site [chemical binding]; other site 1230340003829 Walker B motif; other site 1230340003830 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1230340003831 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1230340003832 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1230340003833 Catalytic site [active] 1230340003834 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1230340003835 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1230340003836 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1230340003837 Catalytic site [active] 1230340003838 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1230340003839 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1230340003840 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1230340003841 Catalytic site [active] 1230340003842 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1230340003843 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1230340003844 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1230340003845 GTP/Mg2+ binding site [chemical binding]; other site 1230340003846 G4 box; other site 1230340003847 G5 box; other site 1230340003848 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1230340003849 G1 box; other site 1230340003850 G1 box; other site 1230340003851 GTP/Mg2+ binding site [chemical binding]; other site 1230340003852 Switch I region; other site 1230340003853 G2 box; other site 1230340003854 G2 box; other site 1230340003855 G3 box; other site 1230340003856 G3 box; other site 1230340003857 Switch II region; other site 1230340003858 Switch II region; other site 1230340003859 G5 box; other site 1230340003860 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1230340003861 RNA/DNA hybrid binding site [nucleotide binding]; other site 1230340003862 active site 1230340003863 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1230340003864 DNA protecting protein DprA; Region: dprA; TIGR00732 1230340003865 DNA topoisomerase I; Validated; Region: PRK05582 1230340003866 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1230340003867 active site 1230340003868 interdomain interaction site; other site 1230340003869 putative metal-binding site [ion binding]; other site 1230340003870 nucleotide binding site [chemical binding]; other site 1230340003871 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1230340003872 domain I; other site 1230340003873 DNA binding groove [nucleotide binding] 1230340003874 phosphate binding site [ion binding]; other site 1230340003875 domain II; other site 1230340003876 domain III; other site 1230340003877 nucleotide binding site [chemical binding]; other site 1230340003878 catalytic site [active] 1230340003879 domain IV; other site 1230340003880 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1230340003881 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1230340003882 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1230340003883 Glucose inhibited division protein A; Region: GIDA; pfam01134 1230340003884 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1230340003885 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1230340003886 active site 1230340003887 DNA binding site [nucleotide binding] 1230340003888 Int/Topo IB signature motif; other site 1230340003889 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1230340003890 active site 1230340003891 HslU subunit interaction site [polypeptide binding]; other site 1230340003892 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1230340003893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340003894 Walker A motif; other site 1230340003895 ATP binding site [chemical binding]; other site 1230340003896 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1230340003897 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1230340003898 transcriptional repressor CodY; Validated; Region: PRK04158 1230340003899 CodY GAF-like domain; Region: CodY; pfam06018 1230340003900 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1230340003901 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1230340003902 active site 1230340003903 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1230340003904 active site 1230340003905 catalytic residues [active] 1230340003906 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1230340003907 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1230340003908 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1230340003909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340003910 Mg2+ binding site [ion binding]; other site 1230340003911 G-X-G motif; other site 1230340003912 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1230340003913 anchoring element; other site 1230340003914 dimer interface [polypeptide binding]; other site 1230340003915 ATP binding site [chemical binding]; other site 1230340003916 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1230340003917 active site 1230340003918 putative metal-binding site [ion binding]; other site 1230340003919 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1230340003920 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1230340003921 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1230340003922 CAP-like domain; other site 1230340003923 active site 1230340003924 primary dimer interface [polypeptide binding]; other site 1230340003925 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1230340003926 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1230340003927 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1230340003928 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340003929 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1230340003930 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1230340003931 catalytic triad [active] 1230340003932 catalytic triad [active] 1230340003933 oxyanion hole [active] 1230340003934 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1230340003935 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1230340003936 active site 1230340003937 catalytic site [active] 1230340003938 metal binding site [ion binding]; metal-binding site 1230340003939 dimer interface [polypeptide binding]; other site 1230340003940 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1230340003941 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1230340003942 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1230340003943 bacterial Hfq-like; Region: Hfq; cd01716 1230340003944 hexamer interface [polypeptide binding]; other site 1230340003945 Sm1 motif; other site 1230340003946 RNA binding site [nucleotide binding]; other site 1230340003947 Sm2 motif; other site 1230340003948 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1230340003949 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1230340003950 HflX GTPase family; Region: HflX; cd01878 1230340003951 G1 box; other site 1230340003952 GTP/Mg2+ binding site [chemical binding]; other site 1230340003953 Switch I region; other site 1230340003954 G2 box; other site 1230340003955 G3 box; other site 1230340003956 Switch II region; other site 1230340003957 G4 box; other site 1230340003958 G5 box; other site 1230340003959 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1230340003960 Aluminium resistance protein; Region: Alum_res; pfam06838 1230340003961 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1230340003962 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1230340003963 DNA binding residues [nucleotide binding] 1230340003964 putative dimer interface [polypeptide binding]; other site 1230340003965 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1230340003966 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1230340003967 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1230340003968 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1230340003969 transmembrane helices; other site 1230340003970 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1230340003971 LexA repressor; Validated; Region: PRK00215 1230340003972 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1230340003973 putative DNA binding site [nucleotide binding]; other site 1230340003974 putative Zn2+ binding site [ion binding]; other site 1230340003975 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1230340003976 Catalytic site [active] 1230340003977 cell division suppressor protein YneA; Provisional; Region: PRK14125 1230340003978 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1230340003979 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1230340003980 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1230340003981 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1230340003982 TPP-binding site [chemical binding]; other site 1230340003983 dimer interface [polypeptide binding]; other site 1230340003984 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1230340003985 PYR/PP interface [polypeptide binding]; other site 1230340003986 dimer interface [polypeptide binding]; other site 1230340003987 TPP binding site [chemical binding]; other site 1230340003988 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1230340003989 hypothetical protein; Provisional; Region: PRK01844 1230340003990 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1230340003991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1230340003992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340003993 S-adenosylmethionine binding site [chemical binding]; other site 1230340003994 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1230340003995 ParB-like nuclease domain; Region: ParBc; pfam02195 1230340003996 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1230340003997 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1230340003998 Active Sites [active] 1230340003999 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1230340004000 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1230340004001 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1230340004002 putative nucleotide binding site [chemical binding]; other site 1230340004003 uridine monophosphate binding site [chemical binding]; other site 1230340004004 homohexameric interface [polypeptide binding]; other site 1230340004005 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1230340004006 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1230340004007 hinge region; other site 1230340004008 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 1230340004009 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1230340004010 catalytic residue [active] 1230340004011 putative FPP diphosphate binding site; other site 1230340004012 putative FPP binding hydrophobic cleft; other site 1230340004013 dimer interface [polypeptide binding]; other site 1230340004014 putative IPP diphosphate binding site; other site 1230340004015 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1230340004016 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1230340004017 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 1230340004018 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1230340004019 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1230340004020 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1230340004021 RIP metalloprotease RseP; Region: TIGR00054 1230340004022 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1230340004023 active site 1230340004024 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1230340004025 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1230340004026 protein binding site [polypeptide binding]; other site 1230340004027 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1230340004028 putative substrate binding region [chemical binding]; other site 1230340004029 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1230340004030 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1230340004031 dimer interface [polypeptide binding]; other site 1230340004032 motif 1; other site 1230340004033 active site 1230340004034 motif 2; other site 1230340004035 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1230340004036 putative deacylase active site [active] 1230340004037 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1230340004038 active site 1230340004039 motif 3; other site 1230340004040 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1230340004041 anticodon binding site; other site 1230340004042 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1230340004043 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1230340004044 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1230340004045 generic binding surface II; other site 1230340004046 generic binding surface I; other site 1230340004047 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1230340004048 active site 1230340004049 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1230340004050 active site 1230340004051 catalytic site [active] 1230340004052 substrate binding site [chemical binding]; other site 1230340004053 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1230340004054 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1230340004055 Sm and related proteins; Region: Sm_like; cl00259 1230340004056 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1230340004057 putative oligomer interface [polypeptide binding]; other site 1230340004058 putative RNA binding site [nucleotide binding]; other site 1230340004059 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1230340004060 NusA N-terminal domain; Region: NusA_N; pfam08529 1230340004061 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1230340004062 RNA binding site [nucleotide binding]; other site 1230340004063 homodimer interface [polypeptide binding]; other site 1230340004064 NusA-like KH domain; Region: KH_5; pfam13184 1230340004065 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1230340004066 G-X-X-G motif; other site 1230340004067 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1230340004068 putative RNA binding cleft [nucleotide binding]; other site 1230340004069 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1230340004070 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1230340004071 translation initiation factor IF-2; Region: IF-2; TIGR00487 1230340004072 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1230340004073 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1230340004074 G1 box; other site 1230340004075 putative GEF interaction site [polypeptide binding]; other site 1230340004076 GTP/Mg2+ binding site [chemical binding]; other site 1230340004077 Switch I region; other site 1230340004078 G2 box; other site 1230340004079 G3 box; other site 1230340004080 Switch II region; other site 1230340004081 G4 box; other site 1230340004082 G5 box; other site 1230340004083 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1230340004084 Translation-initiation factor 2; Region: IF-2; pfam11987 1230340004085 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1230340004086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1230340004087 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1230340004088 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1230340004089 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1230340004090 RNA binding site [nucleotide binding]; other site 1230340004091 active site 1230340004092 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1230340004093 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1230340004094 active site 1230340004095 Riboflavin kinase; Region: Flavokinase; smart00904 1230340004096 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1230340004097 16S/18S rRNA binding site [nucleotide binding]; other site 1230340004098 S13e-L30e interaction site [polypeptide binding]; other site 1230340004099 25S rRNA binding site [nucleotide binding]; other site 1230340004100 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1230340004101 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1230340004102 RNase E interface [polypeptide binding]; other site 1230340004103 trimer interface [polypeptide binding]; other site 1230340004104 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1230340004105 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1230340004106 RNase E interface [polypeptide binding]; other site 1230340004107 trimer interface [polypeptide binding]; other site 1230340004108 active site 1230340004109 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1230340004110 putative nucleic acid binding region [nucleotide binding]; other site 1230340004111 G-X-X-G motif; other site 1230340004112 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1230340004113 RNA binding site [nucleotide binding]; other site 1230340004114 domain interface; other site 1230340004115 GTPase RsgA; Reviewed; Region: PRK01889 1230340004116 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1230340004117 RNA binding site [nucleotide binding]; other site 1230340004118 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1230340004119 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1230340004120 GTP/Mg2+ binding site [chemical binding]; other site 1230340004121 G4 box; other site 1230340004122 G5 box; other site 1230340004123 G1 box; other site 1230340004124 Switch I region; other site 1230340004125 G2 box; other site 1230340004126 G3 box; other site 1230340004127 Switch II region; other site 1230340004128 YceG-like family; Region: YceG; pfam02618 1230340004129 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1230340004130 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1230340004131 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1230340004132 Rhomboid family; Region: Rhomboid; pfam01694 1230340004133 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1230340004134 TPR motif; other site 1230340004135 TPR repeat; Region: TPR_11; pfam13414 1230340004136 binding surface 1230340004137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1230340004138 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1230340004139 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1230340004140 nucleotide binding site [chemical binding]; other site 1230340004141 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1230340004142 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1230340004143 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1230340004144 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1230340004145 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1230340004146 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1230340004147 Type II/IV secretion system protein; Region: T2SE; pfam00437 1230340004148 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1230340004149 Walker A motif; other site 1230340004150 ATP binding site [chemical binding]; other site 1230340004151 Walker B motif; other site 1230340004152 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1230340004153 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1230340004154 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1230340004155 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1230340004156 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1230340004157 tetramer interface [polypeptide binding]; other site 1230340004158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340004159 catalytic residue [active] 1230340004160 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1230340004161 tetramer interface [polypeptide binding]; other site 1230340004162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340004163 catalytic residue [active] 1230340004164 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1230340004165 active site residue [active] 1230340004166 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1230340004167 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1230340004168 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1230340004169 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1230340004170 active site 1230340004171 elongation factor P; Validated; Region: PRK00529 1230340004172 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1230340004173 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1230340004174 RNA binding site [nucleotide binding]; other site 1230340004175 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1230340004176 RNA binding site [nucleotide binding]; other site 1230340004177 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1230340004178 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1230340004179 carboxyltransferase (CT) interaction site; other site 1230340004180 biotinylation site [posttranslational modification]; other site 1230340004181 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1230340004182 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1230340004183 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1230340004184 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1230340004185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1230340004186 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1230340004187 putative RNA binding site [nucleotide binding]; other site 1230340004188 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 1230340004189 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1230340004190 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1230340004191 homodimer interface [polypeptide binding]; other site 1230340004192 NADP binding site [chemical binding]; other site 1230340004193 substrate binding site [chemical binding]; other site 1230340004194 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1230340004195 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1230340004196 generic binding surface II; other site 1230340004197 generic binding surface I; other site 1230340004198 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 1230340004199 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1230340004200 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1230340004201 substrate binding pocket [chemical binding]; other site 1230340004202 chain length determination region; other site 1230340004203 substrate-Mg2+ binding site; other site 1230340004204 catalytic residues [active] 1230340004205 aspartate-rich region 1; other site 1230340004206 active site lid residues [active] 1230340004207 aspartate-rich region 2; other site 1230340004208 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1230340004209 DNA-binding site [nucleotide binding]; DNA binding site 1230340004210 RNA-binding motif; other site 1230340004211 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1230340004212 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1230340004213 TPP-binding site; other site 1230340004214 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1230340004215 PYR/PP interface [polypeptide binding]; other site 1230340004216 dimer interface [polypeptide binding]; other site 1230340004217 TPP binding site [chemical binding]; other site 1230340004218 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1230340004219 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1230340004220 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1230340004221 RNA binding surface [nucleotide binding]; other site 1230340004222 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1230340004223 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1230340004224 arginine repressor; Provisional; Region: PRK04280 1230340004225 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1230340004226 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1230340004227 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1230340004228 Walker A/P-loop; other site 1230340004229 ATP binding site [chemical binding]; other site 1230340004230 Q-loop/lid; other site 1230340004231 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1230340004232 ABC transporter signature motif; other site 1230340004233 Walker B; other site 1230340004234 D-loop; other site 1230340004235 H-loop/switch region; other site 1230340004236 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1230340004237 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1230340004238 nucleotide binding site [chemical binding]; other site 1230340004239 Acetokinase family; Region: Acetate_kinase; cl17229 1230340004240 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1230340004241 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1230340004242 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1230340004243 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1230340004244 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1230340004245 tetramer interface [polypeptide binding]; other site 1230340004246 TPP-binding site [chemical binding]; other site 1230340004247 heterodimer interface [polypeptide binding]; other site 1230340004248 phosphorylation loop region [posttranslational modification] 1230340004249 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1230340004250 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1230340004251 alpha subunit interface [polypeptide binding]; other site 1230340004252 TPP binding site [chemical binding]; other site 1230340004253 heterodimer interface [polypeptide binding]; other site 1230340004254 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1230340004255 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1230340004256 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1230340004257 E3 interaction surface; other site 1230340004258 lipoyl attachment site [posttranslational modification]; other site 1230340004259 e3 binding domain; Region: E3_binding; pfam02817 1230340004260 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1230340004261 peptidase T-like protein; Region: PepT-like; TIGR01883 1230340004262 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1230340004263 metal binding site [ion binding]; metal-binding site 1230340004264 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1230340004265 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1230340004266 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1230340004267 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1230340004268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340004269 active site 1230340004270 phosphorylation site [posttranslational modification] 1230340004271 intermolecular recognition site; other site 1230340004272 dimerization interface [polypeptide binding]; other site 1230340004273 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1230340004274 DNA binding site [nucleotide binding] 1230340004275 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1230340004276 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1230340004277 dimerization interface [polypeptide binding]; other site 1230340004278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1230340004279 dimer interface [polypeptide binding]; other site 1230340004280 phosphorylation site [posttranslational modification] 1230340004281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340004282 ATP binding site [chemical binding]; other site 1230340004283 Mg2+ binding site [ion binding]; other site 1230340004284 G-X-G motif; other site 1230340004285 OxaA-like protein precursor; Validated; Region: PRK01622 1230340004286 acylphosphatase; Provisional; Region: PRK14443 1230340004287 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 1230340004288 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1230340004289 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1230340004290 homotetramer interface [polypeptide binding]; other site 1230340004291 FMN binding site [chemical binding]; other site 1230340004292 homodimer contacts [polypeptide binding]; other site 1230340004293 putative active site [active] 1230340004294 putative substrate binding site [chemical binding]; other site 1230340004295 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1230340004296 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1230340004297 active site residue [active] 1230340004298 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1230340004299 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1230340004300 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1230340004301 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1230340004302 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1230340004303 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1230340004304 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1230340004305 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1230340004306 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 1230340004307 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1230340004308 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1230340004309 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1230340004310 ligand binding site [chemical binding]; other site 1230340004311 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1230340004312 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1230340004313 Walker A/P-loop; other site 1230340004314 ATP binding site [chemical binding]; other site 1230340004315 Q-loop/lid; other site 1230340004316 ABC transporter signature motif; other site 1230340004317 Walker B; other site 1230340004318 D-loop; other site 1230340004319 H-loop/switch region; other site 1230340004320 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1230340004321 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1230340004322 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1230340004323 TM-ABC transporter signature motif; other site 1230340004324 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1230340004325 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1230340004326 TM-ABC transporter signature motif; other site 1230340004327 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1230340004328 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1230340004329 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1230340004330 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1230340004331 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1230340004332 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1230340004333 classical (c) SDRs; Region: SDR_c; cd05233 1230340004334 NAD(P) binding site [chemical binding]; other site 1230340004335 active site 1230340004336 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1230340004337 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1230340004338 competence damage-inducible protein A; Provisional; Region: PRK00549 1230340004339 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1230340004340 putative MPT binding site; other site 1230340004341 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1230340004342 recombinase A; Provisional; Region: recA; PRK09354 1230340004343 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1230340004344 hexamer interface [polypeptide binding]; other site 1230340004345 Walker A motif; other site 1230340004346 ATP binding site [chemical binding]; other site 1230340004347 Walker B motif; other site 1230340004348 phosphodiesterase; Provisional; Region: PRK12704 1230340004349 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1230340004350 Zn2+ binding site [ion binding]; other site 1230340004351 Mg2+ binding site [ion binding]; other site 1230340004352 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1230340004353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340004354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1230340004355 Coenzyme A binding pocket [chemical binding]; other site 1230340004356 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1230340004357 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1230340004358 putative active site [active] 1230340004359 metal binding site [ion binding]; metal-binding site 1230340004360 homodimer binding site [polypeptide binding]; other site 1230340004361 Predicted membrane protein [Function unknown]; Region: COG4550 1230340004362 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1230340004363 MutS domain I; Region: MutS_I; pfam01624 1230340004364 MutS domain II; Region: MutS_II; pfam05188 1230340004365 MutS domain III; Region: MutS_III; pfam05192 1230340004366 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1230340004367 Walker A/P-loop; other site 1230340004368 ATP binding site [chemical binding]; other site 1230340004369 Q-loop/lid; other site 1230340004370 ABC transporter signature motif; other site 1230340004371 Walker B; other site 1230340004372 D-loop; other site 1230340004373 H-loop/switch region; other site 1230340004374 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1230340004375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340004376 ATP binding site [chemical binding]; other site 1230340004377 Mg2+ binding site [ion binding]; other site 1230340004378 G-X-G motif; other site 1230340004379 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1230340004380 ATP binding site [chemical binding]; other site 1230340004381 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1230340004382 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1230340004383 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1230340004384 Pyruvate formate lyase 1; Region: PFL1; cd01678 1230340004385 coenzyme A binding site [chemical binding]; other site 1230340004386 active site 1230340004387 catalytic residues [active] 1230340004388 glycine loop; other site 1230340004389 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1230340004390 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1230340004391 FeS/SAM binding site; other site 1230340004392 Predicted transcriptional regulators [Transcription]; Region: COG1695 1230340004393 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1230340004394 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1230340004395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340004396 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1230340004397 putative substrate translocation pore; other site 1230340004398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340004399 non-specific DNA binding site [nucleotide binding]; other site 1230340004400 salt bridge; other site 1230340004401 sequence-specific DNA binding site [nucleotide binding]; other site 1230340004402 topology modulation protein; Reviewed; Region: PRK08118 1230340004403 AAA domain; Region: AAA_17; pfam13207 1230340004404 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340004405 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340004406 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340004407 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340004408 putative acyltransferase; Provisional; Region: PRK05790 1230340004409 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1230340004410 dimer interface [polypeptide binding]; other site 1230340004411 active site 1230340004412 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1230340004413 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1230340004414 dimer interface [polypeptide binding]; other site 1230340004415 active site 1230340004416 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1230340004417 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1230340004418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340004419 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1230340004420 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1230340004421 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1230340004422 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1230340004423 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1230340004424 FAD binding domain; Region: FAD_binding_4; pfam01565 1230340004425 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1230340004426 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1230340004427 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1230340004428 Walker A/P-loop; other site 1230340004429 ATP binding site [chemical binding]; other site 1230340004430 Q-loop/lid; other site 1230340004431 ABC transporter signature motif; other site 1230340004432 Walker B; other site 1230340004433 D-loop; other site 1230340004434 H-loop/switch region; other site 1230340004435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340004436 dimer interface [polypeptide binding]; other site 1230340004437 conserved gate region; other site 1230340004438 ABC-ATPase subunit interface; other site 1230340004439 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1230340004440 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1230340004441 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 1230340004442 manganese transport protein MntH; Reviewed; Region: PRK00701 1230340004443 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1230340004444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340004445 dimer interface [polypeptide binding]; other site 1230340004446 conserved gate region; other site 1230340004447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1230340004448 ABC-ATPase subunit interface; other site 1230340004449 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1230340004450 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1230340004451 dimerization interface [polypeptide binding]; other site 1230340004452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340004453 dimer interface [polypeptide binding]; other site 1230340004454 conserved gate region; other site 1230340004455 putative PBP binding loops; other site 1230340004456 ABC-ATPase subunit interface; other site 1230340004457 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1230340004458 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1230340004459 Walker A/P-loop; other site 1230340004460 ATP binding site [chemical binding]; other site 1230340004461 Q-loop/lid; other site 1230340004462 ABC transporter signature motif; other site 1230340004463 Walker B; other site 1230340004464 D-loop; other site 1230340004465 H-loop/switch region; other site 1230340004466 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1230340004467 Predicted membrane protein [Function unknown]; Region: COG3859 1230340004468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1230340004469 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1230340004470 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1230340004471 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1230340004472 ABC transporter; Region: ABC_tran_2; pfam12848 1230340004473 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1230340004474 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1230340004475 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1230340004476 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1230340004477 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1230340004478 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1230340004479 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1230340004480 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1230340004481 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1230340004482 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1230340004483 dimer interface [polypeptide binding]; other site 1230340004484 active site 1230340004485 catalytic residue [active] 1230340004486 aspartate kinase I; Reviewed; Region: PRK08210 1230340004487 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1230340004488 nucleotide binding site [chemical binding]; other site 1230340004489 substrate binding site [chemical binding]; other site 1230340004490 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1230340004491 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1230340004492 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1230340004493 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1230340004494 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1230340004495 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1230340004496 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1230340004497 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1230340004498 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1230340004499 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1230340004500 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1230340004501 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1230340004502 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1230340004503 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1230340004504 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1230340004505 Predicted membrane protein [Function unknown]; Region: COG4392 1230340004506 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1230340004507 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1230340004508 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1230340004509 metal binding site 2 [ion binding]; metal-binding site 1230340004510 putative DNA binding helix; other site 1230340004511 metal binding site 1 [ion binding]; metal-binding site 1230340004512 dimer interface [polypeptide binding]; other site 1230340004513 structural Zn2+ binding site [ion binding]; other site 1230340004514 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1230340004515 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1230340004516 ABC-ATPase subunit interface; other site 1230340004517 dimer interface [polypeptide binding]; other site 1230340004518 putative PBP binding regions; other site 1230340004519 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1230340004520 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1230340004521 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1230340004522 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1230340004523 DHHA2 domain; Region: DHHA2; pfam02833 1230340004524 endonuclease IV; Provisional; Region: PRK01060 1230340004525 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1230340004526 AP (apurinic/apyrimidinic) site pocket; other site 1230340004527 DNA interaction; other site 1230340004528 Metal-binding active site; metal-binding site 1230340004529 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1230340004530 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1230340004531 ATP binding site [chemical binding]; other site 1230340004532 Mg++ binding site [ion binding]; other site 1230340004533 motif III; other site 1230340004534 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1230340004535 nucleotide binding region [chemical binding]; other site 1230340004536 ATP-binding site [chemical binding]; other site 1230340004537 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1230340004538 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1230340004539 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1230340004540 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1230340004541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1230340004542 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1230340004543 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1230340004544 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1230340004545 Family of unknown function (DUF633); Region: DUF633; pfam04816 1230340004546 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1230340004547 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1230340004548 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1230340004549 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1230340004550 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1230340004551 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1230340004552 DNA binding residues [nucleotide binding] 1230340004553 DNA primase; Validated; Region: dnaG; PRK05667 1230340004554 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1230340004555 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1230340004556 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1230340004557 active site 1230340004558 metal binding site [ion binding]; metal-binding site 1230340004559 interdomain interaction site; other site 1230340004560 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1230340004561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1230340004562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 1230340004563 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1230340004564 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1230340004565 DALR anticodon binding domain; Region: DALR_1; pfam05746 1230340004566 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1230340004567 dimer interface [polypeptide binding]; other site 1230340004568 motif 1; other site 1230340004569 active site 1230340004570 motif 2; other site 1230340004571 motif 3; other site 1230340004572 Recombination protein O N terminal; Region: RecO_N; pfam11967 1230340004573 DNA repair protein RecO; Region: reco; TIGR00613 1230340004574 Recombination protein O C terminal; Region: RecO_C; pfam02565 1230340004575 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1230340004576 GTPase Era; Reviewed; Region: era; PRK00089 1230340004577 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1230340004578 G1 box; other site 1230340004579 GTP/Mg2+ binding site [chemical binding]; other site 1230340004580 Switch I region; other site 1230340004581 G2 box; other site 1230340004582 Switch II region; other site 1230340004583 G3 box; other site 1230340004584 G4 box; other site 1230340004585 G5 box; other site 1230340004586 KH domain; Region: KH_2; pfam07650 1230340004587 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1230340004588 metal-binding heat shock protein; Provisional; Region: PRK00016 1230340004589 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1230340004590 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1230340004591 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1230340004592 Zn2+ binding site [ion binding]; other site 1230340004593 Mg2+ binding site [ion binding]; other site 1230340004594 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1230340004595 PhoH-like protein; Region: PhoH; pfam02562 1230340004596 Yqey-like protein; Region: YqeY; pfam09424 1230340004597 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1230340004598 RNA methyltransferase, RsmE family; Region: TIGR00046 1230340004599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1230340004600 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1230340004601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340004602 S-adenosylmethionine binding site [chemical binding]; other site 1230340004603 chaperone protein DnaJ; Provisional; Region: PRK14280 1230340004604 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1230340004605 HSP70 interaction site [polypeptide binding]; other site 1230340004606 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1230340004607 substrate binding site [polypeptide binding]; other site 1230340004608 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1230340004609 Zn binding sites [ion binding]; other site 1230340004610 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1230340004611 dimer interface [polypeptide binding]; other site 1230340004612 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1230340004613 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1230340004614 nucleotide binding site [chemical binding]; other site 1230340004615 NEF interaction site [polypeptide binding]; other site 1230340004616 SBD interface [polypeptide binding]; other site 1230340004617 heat shock protein GrpE; Provisional; Region: PRK14140 1230340004618 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1230340004619 dimer interface [polypeptide binding]; other site 1230340004620 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1230340004621 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1230340004622 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1230340004623 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1230340004624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1230340004625 FeS/SAM binding site; other site 1230340004626 HemN C-terminal domain; Region: HemN_C; pfam06969 1230340004627 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1230340004628 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1230340004629 NADP binding site [chemical binding]; other site 1230340004630 putative substrate binding site [chemical binding]; other site 1230340004631 active site 1230340004632 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1230340004633 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1230340004634 DNA binding residues [nucleotide binding] 1230340004635 putative dimer interface [polypeptide binding]; other site 1230340004636 GTP-binding protein LepA; Provisional; Region: PRK05433 1230340004637 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1230340004638 G1 box; other site 1230340004639 putative GEF interaction site [polypeptide binding]; other site 1230340004640 GTP/Mg2+ binding site [chemical binding]; other site 1230340004641 Switch I region; other site 1230340004642 G2 box; other site 1230340004643 G3 box; other site 1230340004644 Switch II region; other site 1230340004645 G4 box; other site 1230340004646 G5 box; other site 1230340004647 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1230340004648 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1230340004649 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1230340004650 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1230340004651 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1230340004652 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1230340004653 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1230340004654 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1230340004655 Competence protein; Region: Competence; pfam03772 1230340004656 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1230340004657 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1230340004658 catalytic motif [active] 1230340004659 Zn binding site [ion binding]; other site 1230340004660 SLBB domain; Region: SLBB; pfam10531 1230340004661 comEA protein; Region: comE; TIGR01259 1230340004662 Helix-hairpin-helix motif; Region: HHH; pfam00633 1230340004663 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1230340004664 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1230340004665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340004666 S-adenosylmethionine binding site [chemical binding]; other site 1230340004667 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1230340004668 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1230340004669 Zn2+ binding site [ion binding]; other site 1230340004670 Mg2+ binding site [ion binding]; other site 1230340004671 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1230340004672 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1230340004673 active site 1230340004674 (T/H)XGH motif; other site 1230340004675 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1230340004676 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1230340004677 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1230340004678 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1230340004679 shikimate binding site; other site 1230340004680 NAD(P) binding site [chemical binding]; other site 1230340004681 GTPase YqeH; Provisional; Region: PRK13796 1230340004682 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1230340004683 GTP/Mg2+ binding site [chemical binding]; other site 1230340004684 G4 box; other site 1230340004685 G5 box; other site 1230340004686 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1230340004687 G1 box; other site 1230340004688 G1 box; other site 1230340004689 GTP/Mg2+ binding site [chemical binding]; other site 1230340004690 G2 box; other site 1230340004691 Switch I region; other site 1230340004692 G2 box; other site 1230340004693 Switch I region; other site 1230340004694 G3 box; other site 1230340004695 G3 box; other site 1230340004696 Switch II region; other site 1230340004697 Switch II region; other site 1230340004698 G4 box; other site 1230340004699 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1230340004700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340004701 motif II; other site 1230340004702 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1230340004703 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1230340004704 active site 1230340004705 Zn binding site [ion binding]; other site 1230340004706 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1230340004707 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1230340004708 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1230340004709 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1230340004710 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1230340004711 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1230340004712 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1230340004713 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1230340004714 Sugar specificity; other site 1230340004715 Pyrimidine base specificity; other site 1230340004716 ATP-binding site [chemical binding]; other site 1230340004717 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1230340004718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340004719 S-adenosylmethionine binding site [chemical binding]; other site 1230340004720 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1230340004721 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1230340004722 dimerization interface [polypeptide binding]; other site 1230340004723 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1230340004724 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1230340004725 hypothetical protein; Provisional; Region: PRK13678 1230340004726 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1230340004727 hypothetical protein; Provisional; Region: PRK05473 1230340004728 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1230340004729 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1230340004730 motif 1; other site 1230340004731 active site 1230340004732 motif 2; other site 1230340004733 motif 3; other site 1230340004734 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1230340004735 DHHA1 domain; Region: DHHA1; pfam02272 1230340004736 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1230340004737 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1230340004738 Walker A/P-loop; other site 1230340004739 ATP binding site [chemical binding]; other site 1230340004740 Q-loop/lid; other site 1230340004741 ABC transporter signature motif; other site 1230340004742 Walker B; other site 1230340004743 D-loop; other site 1230340004744 H-loop/switch region; other site 1230340004745 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1230340004746 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1230340004747 FtsX-like permease family; Region: FtsX; pfam02687 1230340004748 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1230340004749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340004750 active site 1230340004751 phosphorylation site [posttranslational modification] 1230340004752 intermolecular recognition site; other site 1230340004753 dimerization interface [polypeptide binding]; other site 1230340004754 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1230340004755 DNA binding site [nucleotide binding] 1230340004756 sensor kinase CusS; Provisional; Region: PRK09835 1230340004757 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1230340004758 dimerization interface [polypeptide binding]; other site 1230340004759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1230340004760 dimer interface [polypeptide binding]; other site 1230340004761 phosphorylation site [posttranslational modification] 1230340004762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340004763 ATP binding site [chemical binding]; other site 1230340004764 Mg2+ binding site [ion binding]; other site 1230340004765 G-X-G motif; other site 1230340004766 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1230340004767 AAA domain; Region: AAA_30; pfam13604 1230340004768 Family description; Region: UvrD_C_2; pfam13538 1230340004769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1230340004770 binding surface 1230340004771 TPR motif; other site 1230340004772 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1230340004773 TPR repeat; Region: TPR_11; pfam13414 1230340004774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1230340004775 binding surface 1230340004776 TPR motif; other site 1230340004777 TPR repeat; Region: TPR_11; pfam13414 1230340004778 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1230340004779 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1230340004780 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1230340004781 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1230340004782 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1230340004783 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1230340004784 catalytic residue [active] 1230340004785 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 1230340004786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340004787 Walker A motif; other site 1230340004788 ATP binding site [chemical binding]; other site 1230340004789 Walker B motif; other site 1230340004790 arginine finger; other site 1230340004791 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1230340004792 Predicted transcriptional regulator [Transcription]; Region: COG1959 1230340004793 Transcriptional regulator; Region: Rrf2; pfam02082 1230340004794 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1230340004795 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1230340004796 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1230340004797 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1230340004798 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1230340004799 dimer interface [polypeptide binding]; other site 1230340004800 anticodon binding site; other site 1230340004801 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1230340004802 homodimer interface [polypeptide binding]; other site 1230340004803 motif 1; other site 1230340004804 active site 1230340004805 motif 2; other site 1230340004806 GAD domain; Region: GAD; pfam02938 1230340004807 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1230340004808 motif 3; other site 1230340004809 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1230340004810 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1230340004811 dimer interface [polypeptide binding]; other site 1230340004812 motif 1; other site 1230340004813 active site 1230340004814 motif 2; other site 1230340004815 motif 3; other site 1230340004816 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1230340004817 anticodon binding site; other site 1230340004818 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1230340004819 Bacterial SH3 domain; Region: SH3_3; pfam08239 1230340004820 Bacterial SH3 domain; Region: SH3_3; pfam08239 1230340004821 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1230340004822 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1230340004823 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1230340004824 active site 1230340004825 metal binding site [ion binding]; metal-binding site 1230340004826 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1230340004827 putative active site [active] 1230340004828 dimerization interface [polypeptide binding]; other site 1230340004829 putative tRNAtyr binding site [nucleotide binding]; other site 1230340004830 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1230340004831 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1230340004832 Zn2+ binding site [ion binding]; other site 1230340004833 Mg2+ binding site [ion binding]; other site 1230340004834 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1230340004835 synthetase active site [active] 1230340004836 NTP binding site [chemical binding]; other site 1230340004837 metal binding site [ion binding]; metal-binding site 1230340004838 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1230340004839 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1230340004840 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1230340004841 active site 1230340004842 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1230340004843 DHH family; Region: DHH; pfam01368 1230340004844 DHHA1 domain; Region: DHHA1; pfam02272 1230340004845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1230340004846 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1230340004847 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1230340004848 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1230340004849 Protein export membrane protein; Region: SecD_SecF; cl14618 1230340004850 Protein export membrane protein; Region: SecD_SecF; pfam02355 1230340004851 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1230340004852 Preprotein translocase subunit; Region: YajC; pfam02699 1230340004853 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1230340004854 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1230340004855 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1230340004856 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1230340004857 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1230340004858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340004859 Walker A motif; other site 1230340004860 ATP binding site [chemical binding]; other site 1230340004861 Walker B motif; other site 1230340004862 arginine finger; other site 1230340004863 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1230340004864 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 1230340004865 RuvA N terminal domain; Region: RuvA_N; pfam01330 1230340004866 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1230340004867 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1230340004868 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1230340004869 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1230340004870 NAD binding site [chemical binding]; other site 1230340004871 dimer interface [polypeptide binding]; other site 1230340004872 substrate binding site [chemical binding]; other site 1230340004873 hypothetical protein; Validated; Region: PRK00110 1230340004874 prephenate dehydratase; Provisional; Region: PRK11898 1230340004875 Prephenate dehydratase; Region: PDT; pfam00800 1230340004876 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1230340004877 putative L-Phe binding site [chemical binding]; other site 1230340004878 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1230340004879 GTP1/OBG; Region: GTP1_OBG; pfam01018 1230340004880 Obg GTPase; Region: Obg; cd01898 1230340004881 G1 box; other site 1230340004882 GTP/Mg2+ binding site [chemical binding]; other site 1230340004883 Switch I region; other site 1230340004884 G2 box; other site 1230340004885 G3 box; other site 1230340004886 Switch II region; other site 1230340004887 G4 box; other site 1230340004888 G5 box; other site 1230340004889 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1230340004890 glycerol kinase; Provisional; Region: glpK; PRK00047 1230340004891 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1230340004892 N- and C-terminal domain interface [polypeptide binding]; other site 1230340004893 active site 1230340004894 MgATP binding site [chemical binding]; other site 1230340004895 catalytic site [active] 1230340004896 metal binding site [ion binding]; metal-binding site 1230340004897 glycerol binding site [chemical binding]; other site 1230340004898 homotetramer interface [polypeptide binding]; other site 1230340004899 homodimer interface [polypeptide binding]; other site 1230340004900 FBP binding site [chemical binding]; other site 1230340004901 protein IIAGlc interface [polypeptide binding]; other site 1230340004902 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1230340004903 amphipathic channel; other site 1230340004904 Asn-Pro-Ala signature motifs; other site 1230340004905 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1230340004906 hypothetical protein; Provisional; Region: PRK14553 1230340004907 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1230340004908 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1230340004909 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1230340004910 homodimer interface [polypeptide binding]; other site 1230340004911 oligonucleotide binding site [chemical binding]; other site 1230340004912 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1230340004913 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1230340004914 Switch I; other site 1230340004915 Switch II; other site 1230340004916 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1230340004917 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1230340004918 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1230340004919 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1230340004920 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1230340004921 rod shape-determining protein MreC; Region: MreC; pfam04085 1230340004922 rod shape-determining protein MreB; Provisional; Region: PRK13927 1230340004923 MreB and similar proteins; Region: MreB_like; cd10225 1230340004924 nucleotide binding site [chemical binding]; other site 1230340004925 Mg binding site [ion binding]; other site 1230340004926 putative protofilament interaction site [polypeptide binding]; other site 1230340004927 RodZ interaction site [polypeptide binding]; other site 1230340004928 hypothetical protein; Reviewed; Region: PRK00024 1230340004929 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1230340004930 MPN+ (JAMM) motif; other site 1230340004931 Zinc-binding site [ion binding]; other site 1230340004932 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1230340004933 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1230340004934 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1230340004935 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1230340004936 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1230340004937 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1230340004938 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1230340004939 active site 1230340004940 HIGH motif; other site 1230340004941 nucleotide binding site [chemical binding]; other site 1230340004942 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1230340004943 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1230340004944 active site 1230340004945 KMSKS motif; other site 1230340004946 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1230340004947 tRNA binding surface [nucleotide binding]; other site 1230340004948 anticodon binding site; other site 1230340004949 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1230340004950 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1230340004951 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1230340004952 inhibitor-cofactor binding pocket; inhibition site 1230340004953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340004954 catalytic residue [active] 1230340004955 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1230340004956 dimer interface [polypeptide binding]; other site 1230340004957 active site 1230340004958 Schiff base residues; other site 1230340004959 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1230340004960 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1230340004961 active site 1230340004962 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1230340004963 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1230340004964 domain interfaces; other site 1230340004965 active site 1230340004966 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1230340004967 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1230340004968 tRNA; other site 1230340004969 putative tRNA binding site [nucleotide binding]; other site 1230340004970 putative NADP binding site [chemical binding]; other site 1230340004971 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1230340004972 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1230340004973 G1 box; other site 1230340004974 GTP/Mg2+ binding site [chemical binding]; other site 1230340004975 Switch I region; other site 1230340004976 G2 box; other site 1230340004977 G3 box; other site 1230340004978 Switch II region; other site 1230340004979 G4 box; other site 1230340004980 G5 box; other site 1230340004981 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1230340004982 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1230340004983 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1230340004984 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1230340004985 active site 1230340004986 dimer interface [polypeptide binding]; other site 1230340004987 motif 1; other site 1230340004988 motif 2; other site 1230340004989 motif 3; other site 1230340004990 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1230340004991 anticodon binding site; other site 1230340004992 primosomal protein DnaI; Reviewed; Region: PRK08939 1230340004993 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1230340004994 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1230340004995 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1230340004996 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1230340004997 ATP cone domain; Region: ATP-cone; pfam03477 1230340004998 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1230340004999 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1230340005000 CoA-binding site [chemical binding]; other site 1230340005001 ATP-binding [chemical binding]; other site 1230340005002 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1230340005003 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1230340005004 DNA binding site [nucleotide binding] 1230340005005 catalytic residue [active] 1230340005006 H2TH interface [polypeptide binding]; other site 1230340005007 putative catalytic residues [active] 1230340005008 turnover-facilitating residue; other site 1230340005009 intercalation triad [nucleotide binding]; other site 1230340005010 8OG recognition residue [nucleotide binding]; other site 1230340005011 putative reading head residues; other site 1230340005012 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1230340005013 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1230340005014 DNA polymerase I; Provisional; Region: PRK05755 1230340005015 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1230340005016 active site 1230340005017 metal binding site 1 [ion binding]; metal-binding site 1230340005018 putative 5' ssDNA interaction site; other site 1230340005019 metal binding site 3; metal-binding site 1230340005020 metal binding site 2 [ion binding]; metal-binding site 1230340005021 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1230340005022 putative DNA binding site [nucleotide binding]; other site 1230340005023 putative metal binding site [ion binding]; other site 1230340005024 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1230340005025 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1230340005026 active site 1230340005027 DNA binding site [nucleotide binding] 1230340005028 catalytic site [active] 1230340005029 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1230340005030 isocitrate dehydrogenase; Validated; Region: PRK07362 1230340005031 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1230340005032 dimer interface [polypeptide binding]; other site 1230340005033 Citrate synthase; Region: Citrate_synt; pfam00285 1230340005034 active site 1230340005035 citrylCoA binding site [chemical binding]; other site 1230340005036 oxalacetate/citrate binding site [chemical binding]; other site 1230340005037 coenzyme A binding site [chemical binding]; other site 1230340005038 catalytic triad [active] 1230340005039 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1230340005040 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1230340005041 pyruvate kinase; Provisional; Region: PRK06354 1230340005042 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1230340005043 domain interfaces; other site 1230340005044 active site 1230340005045 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1230340005046 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1230340005047 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1230340005048 active site 1230340005049 ADP/pyrophosphate binding site [chemical binding]; other site 1230340005050 dimerization interface [polypeptide binding]; other site 1230340005051 allosteric effector site; other site 1230340005052 fructose-1,6-bisphosphate binding site; other site 1230340005053 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1230340005054 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1230340005055 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1230340005056 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1230340005057 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1230340005058 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1230340005059 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1230340005060 active site 1230340005061 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1230340005062 generic binding surface I; other site 1230340005063 generic binding surface II; other site 1230340005064 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1230340005065 DHH family; Region: DHH; pfam01368 1230340005066 DHHA1 domain; Region: DHHA1; pfam02272 1230340005067 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1230340005068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1230340005069 DNA-binding site [nucleotide binding]; DNA binding site 1230340005070 DRTGG domain; Region: DRTGG; pfam07085 1230340005071 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1230340005072 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1230340005073 active site 2 [active] 1230340005074 active site 1 [active] 1230340005075 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1230340005076 metal-dependent hydrolase; Provisional; Region: PRK00685 1230340005077 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1230340005078 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1230340005079 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1230340005080 active site 1230340005081 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1230340005082 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1230340005083 hexamer interface [polypeptide binding]; other site 1230340005084 ligand binding site [chemical binding]; other site 1230340005085 putative active site [active] 1230340005086 NAD(P) binding site [chemical binding]; other site 1230340005087 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1230340005088 Ligand Binding Site [chemical binding]; other site 1230340005089 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1230340005090 propionate/acetate kinase; Provisional; Region: PRK12379 1230340005091 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1230340005092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340005093 S-adenosylmethionine binding site [chemical binding]; other site 1230340005094 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1230340005095 dimer interface [polypeptide binding]; other site 1230340005096 catalytic triad [active] 1230340005097 peroxidatic and resolving cysteines [active] 1230340005098 RDD family; Region: RDD; pfam06271 1230340005099 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1230340005100 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1230340005101 tandem repeat interface [polypeptide binding]; other site 1230340005102 oligomer interface [polypeptide binding]; other site 1230340005103 active site residues [active] 1230340005104 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1230340005105 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1230340005106 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1230340005107 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1230340005108 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1230340005109 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1230340005110 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1230340005111 inhibitor-cofactor binding pocket; inhibition site 1230340005112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340005113 catalytic residue [active] 1230340005114 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1230340005115 nucleotide binding site [chemical binding]; other site 1230340005116 N-acetyl-L-glutamate binding site [chemical binding]; other site 1230340005117 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1230340005118 heterotetramer interface [polypeptide binding]; other site 1230340005119 active site pocket [active] 1230340005120 cleavage site 1230340005121 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1230340005122 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1230340005123 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1230340005124 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1230340005125 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1230340005126 Ligand Binding Site [chemical binding]; other site 1230340005127 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1230340005128 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1230340005129 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1230340005130 catalytic residue [active] 1230340005131 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1230340005132 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1230340005133 GAF domain; Region: GAF_2; pfam13185 1230340005134 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1230340005135 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1230340005136 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1230340005137 RNA binding surface [nucleotide binding]; other site 1230340005138 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1230340005139 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1230340005140 active site 1230340005141 HIGH motif; other site 1230340005142 dimer interface [polypeptide binding]; other site 1230340005143 KMSKS motif; other site 1230340005144 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1230340005145 RNA binding surface [nucleotide binding]; other site 1230340005146 catabolite control protein A; Region: ccpA; TIGR01481 1230340005147 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1230340005148 DNA binding site [nucleotide binding] 1230340005149 domain linker motif; other site 1230340005150 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1230340005151 dimerization interface [polypeptide binding]; other site 1230340005152 effector binding site; other site 1230340005153 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1230340005154 Chorismate mutase type II; Region: CM_2; cl00693 1230340005155 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1230340005156 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1230340005157 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1230340005158 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1230340005159 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1230340005160 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1230340005161 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1230340005162 dimer interface [polypeptide binding]; other site 1230340005163 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1230340005164 catalytic triad [active] 1230340005165 peroxidatic and resolving cysteines [active] 1230340005166 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1230340005167 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1230340005168 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1230340005169 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1230340005170 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1230340005171 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1230340005172 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1230340005173 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1230340005174 putative tRNA-binding site [nucleotide binding]; other site 1230340005175 hypothetical protein; Provisional; Region: PRK13668 1230340005176 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1230340005177 catalytic residues [active] 1230340005178 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1230340005179 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1230340005180 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1230340005181 oligomer interface [polypeptide binding]; other site 1230340005182 active site 1230340005183 metal binding site [ion binding]; metal-binding site 1230340005184 Predicted small secreted protein [Function unknown]; Region: COG5584 1230340005185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 1230340005186 putative homodimer interface [polypeptide binding]; other site 1230340005187 putative homotetramer interface [polypeptide binding]; other site 1230340005188 putative allosteric switch controlling residues; other site 1230340005189 putative metal binding site [ion binding]; other site 1230340005190 putative homodimer-homodimer interface [polypeptide binding]; other site 1230340005191 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1230340005192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340005193 S-adenosylmethionine binding site [chemical binding]; other site 1230340005194 Phosphotransferase enzyme family; Region: APH; pfam01636 1230340005195 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1230340005196 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1230340005197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340005198 putative substrate translocation pore; other site 1230340005199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340005200 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1230340005201 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1230340005202 homodimer interface [polypeptide binding]; other site 1230340005203 substrate-cofactor binding pocket; other site 1230340005204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340005205 catalytic residue [active] 1230340005206 dipeptidase PepV; Reviewed; Region: PRK07318 1230340005207 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1230340005208 active site 1230340005209 metal binding site [ion binding]; metal-binding site 1230340005210 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 1230340005211 nudix motif; other site 1230340005212 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1230340005213 putative substrate binding site [chemical binding]; other site 1230340005214 putative ATP binding site [chemical binding]; other site 1230340005215 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1230340005216 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1230340005217 active site 1230340005218 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1230340005219 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1230340005220 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1230340005221 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1230340005222 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1230340005223 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1230340005224 substrate binding site [chemical binding]; other site 1230340005225 active site 1230340005226 catalytic residues [active] 1230340005227 heterodimer interface [polypeptide binding]; other site 1230340005228 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1230340005229 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1230340005230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340005231 catalytic residue [active] 1230340005232 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1230340005233 active site 1230340005234 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1230340005235 active site 1230340005236 ribulose/triose binding site [chemical binding]; other site 1230340005237 phosphate binding site [ion binding]; other site 1230340005238 substrate (anthranilate) binding pocket [chemical binding]; other site 1230340005239 product (indole) binding pocket [chemical binding]; other site 1230340005240 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1230340005241 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1230340005242 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1230340005243 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1230340005244 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1230340005245 glutamine binding [chemical binding]; other site 1230340005246 catalytic triad [active] 1230340005247 anthranilate synthase component I; Provisional; Region: PRK13570 1230340005248 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1230340005249 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1230340005250 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1230340005251 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1230340005252 putative catalytic cysteine [active] 1230340005253 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1230340005254 putative active site [active] 1230340005255 metal binding site [ion binding]; metal-binding site 1230340005256 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1230340005257 dimer interface [polypeptide binding]; other site 1230340005258 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1230340005259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340005260 Walker A/P-loop; other site 1230340005261 ATP binding site [chemical binding]; other site 1230340005262 Q-loop/lid; other site 1230340005263 ABC transporter signature motif; other site 1230340005264 Walker B; other site 1230340005265 D-loop; other site 1230340005266 H-loop/switch region; other site 1230340005267 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1230340005268 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1230340005269 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1230340005270 putative dimer interface [polypeptide binding]; other site 1230340005271 catalytic triad [active] 1230340005272 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1230340005273 aconitate hydratase; Validated; Region: PRK09277 1230340005274 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1230340005275 substrate binding site [chemical binding]; other site 1230340005276 ligand binding site [chemical binding]; other site 1230340005277 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1230340005278 substrate binding site [chemical binding]; other site 1230340005279 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1230340005280 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1230340005281 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1230340005282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1230340005283 ATP binding site [chemical binding]; other site 1230340005284 putative Mg++ binding site [ion binding]; other site 1230340005285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1230340005286 nucleotide binding region [chemical binding]; other site 1230340005287 ATP-binding site [chemical binding]; other site 1230340005288 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1230340005289 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1230340005290 Walker A/P-loop; other site 1230340005291 ATP binding site [chemical binding]; other site 1230340005292 Q-loop/lid; other site 1230340005293 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1230340005294 ABC transporter signature motif; other site 1230340005295 Walker B; other site 1230340005296 D-loop; other site 1230340005297 H-loop/switch region; other site 1230340005298 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1230340005299 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1230340005300 active site 1230340005301 metal binding site [ion binding]; metal-binding site 1230340005302 DNA binding site [nucleotide binding] 1230340005303 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1230340005304 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1230340005305 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1230340005306 putative acyl-acceptor binding pocket; other site 1230340005307 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1230340005308 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1230340005309 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1230340005310 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1230340005311 Walker A/P-loop; other site 1230340005312 ATP binding site [chemical binding]; other site 1230340005313 Q-loop/lid; other site 1230340005314 ABC transporter signature motif; other site 1230340005315 Walker B; other site 1230340005316 D-loop; other site 1230340005317 H-loop/switch region; other site 1230340005318 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1230340005319 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1230340005320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340005321 Walker A/P-loop; other site 1230340005322 ATP binding site [chemical binding]; other site 1230340005323 Q-loop/lid; other site 1230340005324 ABC transporter signature motif; other site 1230340005325 Walker B; other site 1230340005326 D-loop; other site 1230340005327 H-loop/switch region; other site 1230340005328 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1230340005329 active site 1230340005330 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1230340005331 elongation factor Ts; Provisional; Region: tsf; PRK09377 1230340005332 UBA/TS-N domain; Region: UBA; pfam00627 1230340005333 Elongation factor TS; Region: EF_TS; pfam00889 1230340005334 Elongation factor TS; Region: EF_TS; pfam00889 1230340005335 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1230340005336 rRNA interaction site [nucleotide binding]; other site 1230340005337 S8 interaction site; other site 1230340005338 putative laminin-1 binding site; other site 1230340005339 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1230340005340 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1230340005341 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1230340005342 active site turn [active] 1230340005343 phosphorylation site [posttranslational modification] 1230340005344 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1230340005345 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1230340005346 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1230340005347 putative active site [active] 1230340005348 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1230340005349 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1230340005350 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1230340005351 putative active site [active] 1230340005352 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1230340005353 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1230340005354 HIGH motif; other site 1230340005355 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1230340005356 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1230340005357 active site 1230340005358 KMSKS motif; other site 1230340005359 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1230340005360 tRNA binding surface [nucleotide binding]; other site 1230340005361 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1230340005362 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1230340005363 FeS/SAM binding site; other site 1230340005364 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1230340005365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340005366 S-adenosylmethionine binding site [chemical binding]; other site 1230340005367 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1230340005368 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1230340005369 active site 1230340005370 dimer interface [polypeptide binding]; other site 1230340005371 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1230340005372 Ligand Binding Site [chemical binding]; other site 1230340005373 Molecular Tunnel; other site 1230340005374 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1230340005375 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1230340005376 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1230340005377 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1230340005378 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1230340005379 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1230340005380 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1230340005381 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1230340005382 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1230340005383 NAD binding site [chemical binding]; other site 1230340005384 dimer interface [polypeptide binding]; other site 1230340005385 substrate binding site [chemical binding]; other site 1230340005386 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1230340005387 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1230340005388 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1230340005389 nudix motif; other site 1230340005390 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1230340005391 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1230340005392 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1230340005393 metal binding site [ion binding]; metal-binding site 1230340005394 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1230340005395 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1230340005396 acyl-activating enzyme (AAE) consensus motif; other site 1230340005397 putative AMP binding site [chemical binding]; other site 1230340005398 putative active site [active] 1230340005399 putative CoA binding site [chemical binding]; other site 1230340005400 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1230340005401 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1230340005402 substrate binding site [chemical binding]; other site 1230340005403 oxyanion hole (OAH) forming residues; other site 1230340005404 trimer interface [polypeptide binding]; other site 1230340005405 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1230340005406 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1230340005407 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1230340005408 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1230340005409 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1230340005410 dimer interface [polypeptide binding]; other site 1230340005411 tetramer interface [polypeptide binding]; other site 1230340005412 PYR/PP interface [polypeptide binding]; other site 1230340005413 TPP binding site [chemical binding]; other site 1230340005414 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1230340005415 TPP-binding site; other site 1230340005416 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1230340005417 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1230340005418 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1230340005419 UbiA prenyltransferase family; Region: UbiA; pfam01040 1230340005420 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1230340005421 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1230340005422 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1230340005423 FAD binding site [chemical binding]; other site 1230340005424 cystathionine beta-lyase; Provisional; Region: PRK08064 1230340005425 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1230340005426 homodimer interface [polypeptide binding]; other site 1230340005427 substrate-cofactor binding pocket; other site 1230340005428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340005429 catalytic residue [active] 1230340005430 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1230340005431 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1230340005432 homodimer interface [polypeptide binding]; other site 1230340005433 substrate-cofactor binding pocket; other site 1230340005434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340005435 catalytic residue [active] 1230340005436 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1230340005437 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1230340005438 THF binding site; other site 1230340005439 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1230340005440 substrate binding site [chemical binding]; other site 1230340005441 THF binding site; other site 1230340005442 zinc-binding site [ion binding]; other site 1230340005443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340005444 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1230340005445 putative substrate translocation pore; other site 1230340005446 ferric uptake regulator; Provisional; Region: fur; PRK09462 1230340005447 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1230340005448 metal binding site 2 [ion binding]; metal-binding site 1230340005449 putative DNA binding helix; other site 1230340005450 metal binding site 1 [ion binding]; metal-binding site 1230340005451 dimer interface [polypeptide binding]; other site 1230340005452 structural Zn2+ binding site [ion binding]; other site 1230340005453 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1230340005454 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1230340005455 NAD binding site [chemical binding]; other site 1230340005456 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1230340005457 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1230340005458 inhibitor-cofactor binding pocket; inhibition site 1230340005459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340005460 catalytic residue [active] 1230340005461 Predicted membrane protein [Function unknown]; Region: COG4129 1230340005462 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1230340005463 hypothetical protein; Provisional; Region: PRK13662 1230340005464 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1230340005465 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1230340005466 putative NAD(P) binding site [chemical binding]; other site 1230340005467 active site 1230340005468 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1230340005469 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1230340005470 minor groove reading motif; other site 1230340005471 helix-hairpin-helix signature motif; other site 1230340005472 substrate binding pocket [chemical binding]; other site 1230340005473 active site 1230340005474 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1230340005475 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1230340005476 DNA binding and oxoG recognition site [nucleotide binding] 1230340005477 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1230340005478 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1230340005479 trimer interface [polypeptide binding]; other site 1230340005480 active site 1230340005481 WVELL protein; Region: WVELL; pfam14043 1230340005482 recombination regulator RecX; Provisional; Region: recX; PRK14135 1230340005483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1230340005484 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1230340005485 NAD(P) binding site [chemical binding]; other site 1230340005486 active site 1230340005487 Predicted integral membrane protein [Function unknown]; Region: COG0392 1230340005488 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1230340005489 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1230340005490 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1230340005491 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1230340005492 Cation efflux family; Region: Cation_efflux; pfam01545 1230340005493 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1230340005494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1230340005495 PAS fold; Region: PAS_4; pfam08448 1230340005496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1230340005497 putative active site [active] 1230340005498 heme pocket [chemical binding]; other site 1230340005499 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1230340005500 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1230340005501 dimer interface [polypeptide binding]; other site 1230340005502 putative CheW interface [polypeptide binding]; other site 1230340005503 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1230340005504 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 1230340005505 dimer interface [polypeptide binding]; other site 1230340005506 active site 1230340005507 Mn binding site [ion binding]; other site 1230340005508 TRAM domain; Region: TRAM; cl01282 1230340005509 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1230340005510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340005511 S-adenosylmethionine binding site [chemical binding]; other site 1230340005512 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1230340005513 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1230340005514 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1230340005515 Substrate-binding site [chemical binding]; other site 1230340005516 Substrate specificity [chemical binding]; other site 1230340005517 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1230340005518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 1230340005519 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1230340005520 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1230340005521 active site 1230340005522 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1230340005523 flavodoxin, short chain; Region: flav_short; TIGR01753 1230340005524 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1230340005525 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1230340005526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340005527 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1230340005528 putative substrate translocation pore; other site 1230340005529 MreB and similar proteins; Region: MreB_like; cd10225 1230340005530 putative protofilament interaction site [polypeptide binding]; other site 1230340005531 nucleotide binding site [chemical binding]; other site 1230340005532 RodZ interaction site [polypeptide binding]; other site 1230340005533 Mg binding site [ion binding]; other site 1230340005534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340005535 S-adenosylmethionine binding site [chemical binding]; other site 1230340005536 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1230340005537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1230340005538 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1230340005539 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1230340005540 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1230340005541 methionine cluster; other site 1230340005542 active site 1230340005543 phosphorylation site [posttranslational modification] 1230340005544 metal binding site [ion binding]; metal-binding site 1230340005545 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1230340005546 active site 1230340005547 P-loop; other site 1230340005548 phosphorylation site [posttranslational modification] 1230340005549 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1230340005550 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1230340005551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340005552 Walker A motif; other site 1230340005553 ATP binding site [chemical binding]; other site 1230340005554 Walker B motif; other site 1230340005555 arginine finger; other site 1230340005556 Transcriptional antiterminator [Transcription]; Region: COG3933 1230340005557 PRD domain; Region: PRD; pfam00874 1230340005558 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1230340005559 active pocket/dimerization site; other site 1230340005560 active site 1230340005561 phosphorylation site [posttranslational modification] 1230340005562 PRD domain; Region: PRD; pfam00874 1230340005563 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1230340005564 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1230340005565 ATP binding site [chemical binding]; other site 1230340005566 putative Mg++ binding site [ion binding]; other site 1230340005567 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1230340005568 nucleotide binding region [chemical binding]; other site 1230340005569 ATP-binding site [chemical binding]; other site 1230340005570 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1230340005571 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1230340005572 Walker A/P-loop; other site 1230340005573 ATP binding site [chemical binding]; other site 1230340005574 Q-loop/lid; other site 1230340005575 ABC transporter signature motif; other site 1230340005576 Walker B; other site 1230340005577 D-loop; other site 1230340005578 H-loop/switch region; other site 1230340005579 Predicted transcriptional regulators [Transcription]; Region: COG1725 1230340005580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340005581 DNA-binding site [nucleotide binding]; DNA binding site 1230340005582 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1230340005583 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1230340005584 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1230340005585 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1230340005586 DNA binding site [nucleotide binding] 1230340005587 domain linker motif; other site 1230340005588 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1230340005589 dimerization interface [polypeptide binding]; other site 1230340005590 ligand binding site [chemical binding]; other site 1230340005591 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1230340005592 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1230340005593 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1230340005594 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1230340005595 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1230340005596 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1230340005597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340005598 dimer interface [polypeptide binding]; other site 1230340005599 conserved gate region; other site 1230340005600 putative PBP binding loops; other site 1230340005601 ABC-ATPase subunit interface; other site 1230340005602 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1230340005603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340005604 dimer interface [polypeptide binding]; other site 1230340005605 conserved gate region; other site 1230340005606 putative PBP binding loops; other site 1230340005607 ABC-ATPase subunit interface; other site 1230340005608 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1230340005609 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1230340005610 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1230340005611 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1230340005612 active site 1230340005613 dimer interface [polypeptide binding]; other site 1230340005614 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1230340005615 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1230340005616 active site 1230340005617 FMN binding site [chemical binding]; other site 1230340005618 substrate binding site [chemical binding]; other site 1230340005619 3Fe-4S cluster binding site [ion binding]; other site 1230340005620 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1230340005621 domain interface; other site 1230340005622 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1230340005623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1230340005624 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1230340005625 putative dimerization interface [polypeptide binding]; other site 1230340005626 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1230340005627 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1230340005628 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1230340005629 putative active site [active] 1230340005630 metal binding site [ion binding]; metal-binding site 1230340005631 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1230340005632 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1230340005633 substrate binding pocket [chemical binding]; other site 1230340005634 membrane-bound complex binding site; other site 1230340005635 hinge residues; other site 1230340005636 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1230340005637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340005638 Walker A/P-loop; other site 1230340005639 ATP binding site [chemical binding]; other site 1230340005640 Q-loop/lid; other site 1230340005641 ABC transporter signature motif; other site 1230340005642 Walker B; other site 1230340005643 D-loop; other site 1230340005644 H-loop/switch region; other site 1230340005645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340005646 dimer interface [polypeptide binding]; other site 1230340005647 conserved gate region; other site 1230340005648 putative PBP binding loops; other site 1230340005649 ABC-ATPase subunit interface; other site 1230340005650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1230340005651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1230340005652 dimer interface [polypeptide binding]; other site 1230340005653 phosphorylation site [posttranslational modification] 1230340005654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340005655 ATP binding site [chemical binding]; other site 1230340005656 Mg2+ binding site [ion binding]; other site 1230340005657 G-X-G motif; other site 1230340005658 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1230340005659 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1230340005660 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1230340005661 active site 1230340005662 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1230340005663 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 1230340005664 putative NAD(P) binding site [chemical binding]; other site 1230340005665 active site 1230340005666 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1230340005667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340005668 active site 1230340005669 phosphorylation site [posttranslational modification] 1230340005670 intermolecular recognition site; other site 1230340005671 dimerization interface [polypeptide binding]; other site 1230340005672 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1230340005673 DNA binding site [nucleotide binding] 1230340005674 FtsX-like permease family; Region: FtsX; pfam02687 1230340005675 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1230340005676 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1230340005677 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1230340005678 Walker A/P-loop; other site 1230340005679 ATP binding site [chemical binding]; other site 1230340005680 Q-loop/lid; other site 1230340005681 ABC transporter signature motif; other site 1230340005682 Walker B; other site 1230340005683 D-loop; other site 1230340005684 H-loop/switch region; other site 1230340005685 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1230340005686 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1230340005687 ADP binding site [chemical binding]; other site 1230340005688 magnesium binding site [ion binding]; other site 1230340005689 putative shikimate binding site; other site 1230340005690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 1230340005691 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1230340005692 TRAM domain; Region: TRAM; pfam01938 1230340005693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340005694 S-adenosylmethionine binding site [chemical binding]; other site 1230340005695 putative lipid kinase; Reviewed; Region: PRK13337 1230340005696 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1230340005697 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1230340005698 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1230340005699 GatB domain; Region: GatB_Yqey; pfam02637 1230340005700 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1230340005701 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1230340005702 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1230340005703 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1230340005704 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1230340005705 putative dimer interface [polypeptide binding]; other site 1230340005706 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1230340005707 putative dimer interface [polypeptide binding]; other site 1230340005708 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1230340005709 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1230340005710 nucleotide binding pocket [chemical binding]; other site 1230340005711 K-X-D-G motif; other site 1230340005712 catalytic site [active] 1230340005713 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1230340005714 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1230340005715 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1230340005716 Dimer interface [polypeptide binding]; other site 1230340005717 BRCT sequence motif; other site 1230340005718 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1230340005719 Part of AAA domain; Region: AAA_19; pfam13245 1230340005720 Family description; Region: UvrD_C_2; pfam13538 1230340005721 PcrB family; Region: PcrB; pfam01884 1230340005722 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1230340005723 substrate binding site [chemical binding]; other site 1230340005724 putative active site [active] 1230340005725 dimer interface [polypeptide binding]; other site 1230340005726 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1230340005727 Na2 binding site [ion binding]; other site 1230340005728 putative substrate binding site 1 [chemical binding]; other site 1230340005729 Na binding site 1 [ion binding]; other site 1230340005730 putative substrate binding site 2 [chemical binding]; other site 1230340005731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1230340005732 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1230340005733 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1230340005734 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1230340005735 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1230340005736 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1230340005737 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1230340005738 purine monophosphate binding site [chemical binding]; other site 1230340005739 dimer interface [polypeptide binding]; other site 1230340005740 putative catalytic residues [active] 1230340005741 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1230340005742 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1230340005743 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1230340005744 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1230340005745 active site 1230340005746 substrate binding site [chemical binding]; other site 1230340005747 cosubstrate binding site; other site 1230340005748 catalytic site [active] 1230340005749 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1230340005750 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1230340005751 dimerization interface [polypeptide binding]; other site 1230340005752 putative ATP binding site [chemical binding]; other site 1230340005753 amidophosphoribosyltransferase; Provisional; Region: PRK06781 1230340005754 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1230340005755 active site 1230340005756 tetramer interface [polypeptide binding]; other site 1230340005757 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1230340005758 active site 1230340005759 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1230340005760 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1230340005761 dimerization interface [polypeptide binding]; other site 1230340005762 ATP binding site [chemical binding]; other site 1230340005763 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1230340005764 dimerization interface [polypeptide binding]; other site 1230340005765 ATP binding site [chemical binding]; other site 1230340005766 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1230340005767 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1230340005768 putative active site [active] 1230340005769 catalytic triad [active] 1230340005770 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1230340005771 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1230340005772 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1230340005773 ATP binding site [chemical binding]; other site 1230340005774 active site 1230340005775 substrate binding site [chemical binding]; other site 1230340005776 adenylosuccinate lyase; Provisional; Region: PRK07492 1230340005777 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1230340005778 tetramer interface [polypeptide binding]; other site 1230340005779 active site 1230340005780 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1230340005781 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1230340005782 NAD binding site [chemical binding]; other site 1230340005783 ATP-grasp domain; Region: ATP-grasp; pfam02222 1230340005784 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1230340005785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1230340005786 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1230340005787 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1230340005788 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1230340005789 Zn2+ binding site [ion binding]; other site 1230340005790 Mg2+ binding site [ion binding]; other site 1230340005791 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1230340005792 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1230340005793 Walker A/P-loop; other site 1230340005794 ATP binding site [chemical binding]; other site 1230340005795 Q-loop/lid; other site 1230340005796 ABC transporter signature motif; other site 1230340005797 Walker B; other site 1230340005798 D-loop; other site 1230340005799 H-loop/switch region; other site 1230340005800 peptidase T; Region: peptidase-T; TIGR01882 1230340005801 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1230340005802 metal binding site [ion binding]; metal-binding site 1230340005803 dimer interface [polypeptide binding]; other site 1230340005804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1230340005805 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1230340005806 active site 1230340005807 putative catalytic site [active] 1230340005808 DNA binding site [nucleotide binding] 1230340005809 putative phosphate binding site [ion binding]; other site 1230340005810 metal binding site A [ion binding]; metal-binding site 1230340005811 AP binding site [nucleotide binding]; other site 1230340005812 metal binding site B [ion binding]; metal-binding site 1230340005813 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1230340005814 23S rRNA binding site [nucleotide binding]; other site 1230340005815 L21 binding site [polypeptide binding]; other site 1230340005816 L13 binding site [polypeptide binding]; other site 1230340005817 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1230340005818 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1230340005819 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1230340005820 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1230340005821 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1230340005822 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340005823 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1230340005824 Substrate binding site [chemical binding]; other site 1230340005825 Leucine rich repeat; Region: LRR_8; pfam13855 1230340005826 LRR adjacent; Region: LRR_adjacent; pfam08191 1230340005827 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1230340005828 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1230340005829 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1230340005830 DNA binding residues [nucleotide binding] 1230340005831 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1230340005832 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1230340005833 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1230340005834 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 1230340005835 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1230340005836 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1230340005837 RimM N-terminal domain; Region: RimM; pfam01782 1230340005838 PRC-barrel domain; Region: PRC; pfam05239 1230340005839 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1230340005840 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1230340005841 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1230340005842 catalytic triad [active] 1230340005843 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1230340005844 KH domain; Region: KH_4; pfam13083 1230340005845 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1230340005846 signal recognition particle protein; Provisional; Region: PRK10867 1230340005847 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1230340005848 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1230340005849 P loop; other site 1230340005850 GTP binding site [chemical binding]; other site 1230340005851 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1230340005852 putative DNA-binding protein; Validated; Region: PRK00118 1230340005853 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1230340005854 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1230340005855 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1230340005856 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1230340005857 P loop; other site 1230340005858 GTP binding site [chemical binding]; other site 1230340005859 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1230340005860 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1230340005861 Walker A/P-loop; other site 1230340005862 ATP binding site [chemical binding]; other site 1230340005863 Q-loop/lid; other site 1230340005864 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1230340005865 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1230340005866 linker region; other site 1230340005867 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1230340005868 ABC transporter signature motif; other site 1230340005869 Walker B; other site 1230340005870 D-loop; other site 1230340005871 H-loop/switch region; other site 1230340005872 ribonuclease III; Reviewed; Region: rnc; PRK00102 1230340005873 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1230340005874 dimerization interface [polypeptide binding]; other site 1230340005875 active site 1230340005876 metal binding site [ion binding]; metal-binding site 1230340005877 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1230340005878 dsRNA binding site [nucleotide binding]; other site 1230340005879 acyl carrier protein; Provisional; Region: acpP; PRK00982 1230340005880 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1230340005881 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1230340005882 NAD(P) binding site [chemical binding]; other site 1230340005883 homotetramer interface [polypeptide binding]; other site 1230340005884 homodimer interface [polypeptide binding]; other site 1230340005885 active site 1230340005886 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1230340005887 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1230340005888 putative phosphate acyltransferase; Provisional; Region: PRK05331 1230340005889 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1230340005890 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1230340005891 active site 2 [active] 1230340005892 active site 1 [active] 1230340005893 Y-family of DNA polymerases; Region: PolY; cl12025 1230340005894 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1230340005895 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1230340005896 generic binding surface II; other site 1230340005897 ssDNA binding site; other site 1230340005898 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1230340005899 ATP binding site [chemical binding]; other site 1230340005900 putative Mg++ binding site [ion binding]; other site 1230340005901 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1230340005902 nucleotide binding region [chemical binding]; other site 1230340005903 ATP-binding site [chemical binding]; other site 1230340005904 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1230340005905 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1230340005906 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1230340005907 putative L-serine binding site [chemical binding]; other site 1230340005908 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1230340005909 DAK2 domain; Region: Dak2; pfam02734 1230340005910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1230340005911 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1230340005912 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1230340005913 Thiamine pyrophosphokinase; Region: TPK; cd07995 1230340005914 active site 1230340005915 dimerization interface [polypeptide binding]; other site 1230340005916 thiamine binding site [chemical binding]; other site 1230340005917 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1230340005918 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1230340005919 substrate binding site [chemical binding]; other site 1230340005920 hexamer interface [polypeptide binding]; other site 1230340005921 metal binding site [ion binding]; metal-binding site 1230340005922 GTPase RsgA; Reviewed; Region: PRK00098 1230340005923 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1230340005924 RNA binding site [nucleotide binding]; other site 1230340005925 homodimer interface [polypeptide binding]; other site 1230340005926 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1230340005927 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1230340005928 GTP/Mg2+ binding site [chemical binding]; other site 1230340005929 G4 box; other site 1230340005930 G1 box; other site 1230340005931 Switch I region; other site 1230340005932 G2 box; other site 1230340005933 G3 box; other site 1230340005934 Switch II region; other site 1230340005935 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1230340005936 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1230340005937 active site 1230340005938 ATP binding site [chemical binding]; other site 1230340005939 substrate binding site [chemical binding]; other site 1230340005940 activation loop (A-loop); other site 1230340005941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1230340005942 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1230340005943 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1230340005944 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1230340005945 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1230340005946 Protein phosphatase 2C; Region: PP2C; pfam00481 1230340005947 active site 1230340005948 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1230340005949 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1230340005950 putative RNA binding site [nucleotide binding]; other site 1230340005951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340005952 S-adenosylmethionine binding site [chemical binding]; other site 1230340005953 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1230340005954 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1230340005955 putative active site [active] 1230340005956 substrate binding site [chemical binding]; other site 1230340005957 putative cosubstrate binding site; other site 1230340005958 catalytic site [active] 1230340005959 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1230340005960 substrate binding site [chemical binding]; other site 1230340005961 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1230340005962 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1230340005963 ATP binding site [chemical binding]; other site 1230340005964 putative Mg++ binding site [ion binding]; other site 1230340005965 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1230340005966 ATP-binding site [chemical binding]; other site 1230340005967 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1230340005968 Flavoprotein; Region: Flavoprotein; pfam02441 1230340005969 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1230340005970 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1230340005971 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1230340005972 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1230340005973 catalytic site [active] 1230340005974 G-X2-G-X-G-K; other site 1230340005975 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 1230340005976 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1230340005977 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1230340005978 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1230340005979 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1230340005980 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1230340005981 putative NAD(P) binding site [chemical binding]; other site 1230340005982 homodimer interface [polypeptide binding]; other site 1230340005983 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1230340005984 active site 1230340005985 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1230340005986 active site 1230340005987 dimer interface [polypeptide binding]; other site 1230340005988 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1230340005989 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1230340005990 heterodimer interface [polypeptide binding]; other site 1230340005991 active site 1230340005992 FMN binding site [chemical binding]; other site 1230340005993 homodimer interface [polypeptide binding]; other site 1230340005994 substrate binding site [chemical binding]; other site 1230340005995 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1230340005996 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1230340005997 FAD binding pocket [chemical binding]; other site 1230340005998 FAD binding motif [chemical binding]; other site 1230340005999 phosphate binding motif [ion binding]; other site 1230340006000 beta-alpha-beta structure motif; other site 1230340006001 NAD binding pocket [chemical binding]; other site 1230340006002 Iron coordination center [ion binding]; other site 1230340006003 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1230340006004 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1230340006005 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1230340006006 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1230340006007 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1230340006008 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1230340006009 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1230340006010 IMP binding site; other site 1230340006011 dimer interface [polypeptide binding]; other site 1230340006012 interdomain contacts; other site 1230340006013 partial ornithine binding site; other site 1230340006014 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1230340006015 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1230340006016 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1230340006017 catalytic site [active] 1230340006018 subunit interface [polypeptide binding]; other site 1230340006019 dihydroorotase; Validated; Region: pyrC; PRK09357 1230340006020 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1230340006021 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1230340006022 active site 1230340006023 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1230340006024 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1230340006025 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1230340006026 uracil transporter; Provisional; Region: PRK10720 1230340006027 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1230340006028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1230340006029 active site 1230340006030 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1230340006031 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1230340006032 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1230340006033 RNA binding surface [nucleotide binding]; other site 1230340006034 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1230340006035 active site 1230340006036 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1230340006037 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1230340006038 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1230340006039 multidrug efflux protein; Reviewed; Region: PRK01766 1230340006040 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1230340006041 cation binding site [ion binding]; other site 1230340006042 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1230340006043 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1230340006044 metal binding site [ion binding]; metal-binding site 1230340006045 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1230340006046 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1230340006047 ABC-ATPase subunit interface; other site 1230340006048 dimer interface [polypeptide binding]; other site 1230340006049 putative PBP binding regions; other site 1230340006050 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1230340006051 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1230340006052 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1230340006053 MarR family; Region: MarR; pfam01047 1230340006054 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1230340006055 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1230340006056 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1230340006057 protein binding site [polypeptide binding]; other site 1230340006058 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1230340006059 Catalytic dyad [active] 1230340006060 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1230340006061 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1230340006062 metal-binding site [ion binding] 1230340006063 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1230340006064 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1230340006065 metal-binding site [ion binding] 1230340006066 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1230340006067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340006068 motif II; other site 1230340006069 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1230340006070 putative homodimer interface [polypeptide binding]; other site 1230340006071 putative homotetramer interface [polypeptide binding]; other site 1230340006072 putative allosteric switch controlling residues; other site 1230340006073 putative metal binding site [ion binding]; other site 1230340006074 putative homodimer-homodimer interface [polypeptide binding]; other site 1230340006075 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1230340006076 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1230340006077 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1230340006078 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1230340006079 hypothetical protein; Provisional; Region: PRK13672 1230340006080 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1230340006081 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1230340006082 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1230340006083 SelR domain; Region: SelR; pfam01641 1230340006084 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1230340006085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 1230340006086 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1230340006087 active site 1230340006088 catalytic triad [active] 1230340006089 oxyanion hole [active] 1230340006090 EDD domain protein, DegV family; Region: DegV; TIGR00762 1230340006091 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1230340006092 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1230340006093 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1230340006094 HTH domain; Region: HTH_11; pfam08279 1230340006095 FOG: CBS domain [General function prediction only]; Region: COG0517 1230340006096 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1230340006097 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1230340006098 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1230340006099 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1230340006100 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1230340006101 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1230340006102 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1230340006103 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1230340006104 Predicted membrane protein [Function unknown]; Region: COG4129 1230340006105 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1230340006106 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1230340006107 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1230340006108 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1230340006109 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1230340006110 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1230340006111 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 1230340006112 Clostridial hydrophobic W; Region: ChW; pfam07538 1230340006113 Clostridial hydrophobic W; Region: ChW; pfam07538 1230340006114 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1230340006115 active site 1230340006116 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1230340006117 substrate binding site [chemical binding]; other site 1230340006118 metal binding site [ion binding]; metal-binding site 1230340006119 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1230340006120 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1230340006121 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1230340006122 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1230340006123 folate binding site [chemical binding]; other site 1230340006124 NADP+ binding site [chemical binding]; other site 1230340006125 thymidylate synthase; Region: thym_sym; TIGR03284 1230340006126 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1230340006127 dimerization interface [polypeptide binding]; other site 1230340006128 active site 1230340006129 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1230340006130 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1230340006131 Walker A/P-loop; other site 1230340006132 ATP binding site [chemical binding]; other site 1230340006133 Q-loop/lid; other site 1230340006134 ABC transporter signature motif; other site 1230340006135 Walker B; other site 1230340006136 D-loop; other site 1230340006137 H-loop/switch region; other site 1230340006138 ABC transporter; Region: ABC_tran_2; pfam12848 1230340006139 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1230340006140 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1230340006141 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1230340006142 Potassium binding sites [ion binding]; other site 1230340006143 Cesium cation binding sites [ion binding]; other site 1230340006144 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1230340006145 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1230340006146 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1230340006147 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1230340006148 DNA-binding site [nucleotide binding]; DNA binding site 1230340006149 RNA-binding motif; other site 1230340006150 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1230340006151 RNA/DNA hybrid binding site [nucleotide binding]; other site 1230340006152 active site 1230340006153 5'-3' exonuclease; Region: 53EXOc; smart00475 1230340006154 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1230340006155 active site 1230340006156 metal binding site 1 [ion binding]; metal-binding site 1230340006157 putative 5' ssDNA interaction site; other site 1230340006158 metal binding site 3; metal-binding site 1230340006159 metal binding site 2 [ion binding]; metal-binding site 1230340006160 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1230340006161 putative DNA binding site [nucleotide binding]; other site 1230340006162 putative metal binding site [ion binding]; other site 1230340006163 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1230340006164 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1230340006165 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1230340006166 putative active site [active] 1230340006167 xanthine permease; Region: pbuX; TIGR03173 1230340006168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1230340006169 active site 1230340006170 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1230340006171 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1230340006172 active site 1230340006173 Zn binding site [ion binding]; other site 1230340006174 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1230340006175 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1230340006176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1230340006177 cell division protein GpsB; Provisional; Region: PRK14127 1230340006178 DivIVA domain; Region: DivI1A_domain; TIGR03544 1230340006179 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 1230340006180 hypothetical protein; Provisional; Region: PRK13660 1230340006181 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1230340006182 Transglycosylase; Region: Transgly; pfam00912 1230340006183 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1230340006184 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1230340006185 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1230340006186 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1230340006187 minor groove reading motif; other site 1230340006188 helix-hairpin-helix signature motif; other site 1230340006189 substrate binding pocket [chemical binding]; other site 1230340006190 active site 1230340006191 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1230340006192 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1230340006193 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1230340006194 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1230340006195 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1230340006196 putative dimer interface [polypeptide binding]; other site 1230340006197 putative anticodon binding site; other site 1230340006198 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1230340006199 homodimer interface [polypeptide binding]; other site 1230340006200 motif 1; other site 1230340006201 motif 2; other site 1230340006202 active site 1230340006203 motif 3; other site 1230340006204 aspartate aminotransferase; Provisional; Region: PRK05764 1230340006205 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1230340006206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340006207 homodimer interface [polypeptide binding]; other site 1230340006208 catalytic residue [active] 1230340006209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1230340006210 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1230340006211 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1230340006212 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1230340006213 active site 1230340006214 catalytic site [active] 1230340006215 substrate binding site [chemical binding]; other site 1230340006216 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1230340006217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1230340006218 putative Mg++ binding site [ion binding]; other site 1230340006219 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1230340006220 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1230340006221 tetramerization interface [polypeptide binding]; other site 1230340006222 active site 1230340006223 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1230340006224 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1230340006225 active site 1230340006226 ATP-binding site [chemical binding]; other site 1230340006227 pantoate-binding site; other site 1230340006228 HXXH motif; other site 1230340006229 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1230340006230 active site 1230340006231 oligomerization interface [polypeptide binding]; other site 1230340006232 metal binding site [ion binding]; metal-binding site 1230340006233 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1230340006234 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1230340006235 catalytic residues [active] 1230340006236 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1230340006237 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1230340006238 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1230340006239 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1230340006240 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1230340006241 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1230340006242 active site 1230340006243 NTP binding site [chemical binding]; other site 1230340006244 metal binding triad [ion binding]; metal-binding site 1230340006245 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1230340006246 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1230340006247 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1230340006248 active site 1230340006249 dimer interfaces [polypeptide binding]; other site 1230340006250 catalytic residues [active] 1230340006251 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1230340006252 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1230340006253 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1230340006254 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1230340006255 homodimer interface [polypeptide binding]; other site 1230340006256 metal binding site [ion binding]; metal-binding site 1230340006257 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1230340006258 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1230340006259 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1230340006260 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1230340006261 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1230340006262 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1230340006263 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1230340006264 metal binding site [ion binding]; metal-binding site 1230340006265 active site 1230340006266 I-site; other site 1230340006267 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1230340006268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1230340006269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1230340006270 metal binding site [ion binding]; metal-binding site 1230340006271 active site 1230340006272 I-site; other site 1230340006273 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1230340006274 malate dehydrogenase; Provisional; Region: PRK13529 1230340006275 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1230340006276 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1230340006277 NAD(P) binding pocket [chemical binding]; other site 1230340006278 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1230340006279 Beta-lactamase; Region: Beta-lactamase; pfam00144 1230340006280 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1230340006281 Pyruvate formate lyase 1; Region: PFL1; cd01678 1230340006282 coenzyme A binding site [chemical binding]; other site 1230340006283 active site 1230340006284 catalytic residues [active] 1230340006285 glycine loop; other site 1230340006286 HI0933-like protein; Region: HI0933_like; pfam03486 1230340006287 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1230340006288 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1230340006289 Predicted membrane protein [Function unknown]; Region: COG4347 1230340006290 hypothetical protein; Provisional; Region: PRK03636 1230340006291 UPF0302 domain; Region: UPF0302; pfam08864 1230340006292 IDEAL domain; Region: IDEAL; pfam08858 1230340006293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1230340006294 binding surface 1230340006295 TPR motif; other site 1230340006296 TPR repeat; Region: TPR_11; pfam13414 1230340006297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1230340006298 binding surface 1230340006299 TPR motif; other site 1230340006300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1230340006301 binding surface 1230340006302 TPR motif; other site 1230340006303 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1230340006304 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1230340006305 hinge; other site 1230340006306 active site 1230340006307 prephenate dehydrogenase; Validated; Region: PRK06545 1230340006308 prephenate dehydrogenase; Validated; Region: PRK08507 1230340006309 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1230340006310 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1230340006311 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1230340006312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340006313 homodimer interface [polypeptide binding]; other site 1230340006314 catalytic residue [active] 1230340006315 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1230340006316 homotrimer interaction site [polypeptide binding]; other site 1230340006317 active site 1230340006318 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1230340006319 active site 1230340006320 dimer interface [polypeptide binding]; other site 1230340006321 metal binding site [ion binding]; metal-binding site 1230340006322 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1230340006323 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1230340006324 Tetramer interface [polypeptide binding]; other site 1230340006325 active site 1230340006326 FMN-binding site [chemical binding]; other site 1230340006327 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1230340006328 active site 1230340006329 multimer interface [polypeptide binding]; other site 1230340006330 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1230340006331 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1230340006332 substrate binding pocket [chemical binding]; other site 1230340006333 chain length determination region; other site 1230340006334 substrate-Mg2+ binding site; other site 1230340006335 catalytic residues [active] 1230340006336 aspartate-rich region 1; other site 1230340006337 active site lid residues [active] 1230340006338 aspartate-rich region 2; other site 1230340006339 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1230340006340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340006341 S-adenosylmethionine binding site [chemical binding]; other site 1230340006342 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1230340006343 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1230340006344 homodecamer interface [polypeptide binding]; other site 1230340006345 GTP cyclohydrolase I; Provisional; Region: PLN03044 1230340006346 active site 1230340006347 putative catalytic site residues [active] 1230340006348 zinc binding site [ion binding]; other site 1230340006349 GTP-CH-I/GFRP interaction surface; other site 1230340006350 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1230340006351 IHF dimer interface [polypeptide binding]; other site 1230340006352 IHF - DNA interface [nucleotide binding]; other site 1230340006353 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1230340006354 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1230340006355 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1230340006356 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1230340006357 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1230340006358 GTP-binding protein Der; Reviewed; Region: PRK00093 1230340006359 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1230340006360 G1 box; other site 1230340006361 GTP/Mg2+ binding site [chemical binding]; other site 1230340006362 Switch I region; other site 1230340006363 G2 box; other site 1230340006364 Switch II region; other site 1230340006365 G3 box; other site 1230340006366 G4 box; other site 1230340006367 G5 box; other site 1230340006368 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1230340006369 G1 box; other site 1230340006370 GTP/Mg2+ binding site [chemical binding]; other site 1230340006371 Switch I region; other site 1230340006372 G2 box; other site 1230340006373 G3 box; other site 1230340006374 Switch II region; other site 1230340006375 G4 box; other site 1230340006376 G5 box; other site 1230340006377 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1230340006378 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1230340006379 RNA binding site [nucleotide binding]; other site 1230340006380 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1230340006381 RNA binding site [nucleotide binding]; other site 1230340006382 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1230340006383 RNA binding site [nucleotide binding]; other site 1230340006384 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1230340006385 RNA binding site [nucleotide binding]; other site 1230340006386 cytidylate kinase; Provisional; Region: cmk; PRK00023 1230340006387 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1230340006388 CMP-binding site; other site 1230340006389 The sites determining sugar specificity; other site 1230340006390 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1230340006391 active site 1230340006392 homotetramer interface [polypeptide binding]; other site 1230340006393 homodimer interface [polypeptide binding]; other site 1230340006394 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1230340006395 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1230340006396 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1230340006397 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1230340006398 ATP binding site [chemical binding]; other site 1230340006399 putative Mg++ binding site [ion binding]; other site 1230340006400 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1230340006401 nucleotide binding region [chemical binding]; other site 1230340006402 ATP-binding site [chemical binding]; other site 1230340006403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1230340006404 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340006405 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340006406 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340006407 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340006408 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340006409 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340006410 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1230340006411 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340006412 Predicted membrane protein [Function unknown]; Region: COG3601 1230340006413 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1230340006414 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1230340006415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1230340006416 dimerization interface [polypeptide binding]; other site 1230340006417 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1230340006418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1230340006419 dimer interface [polypeptide binding]; other site 1230340006420 phosphorylation site [posttranslational modification] 1230340006421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340006422 ATP binding site [chemical binding]; other site 1230340006423 Mg2+ binding site [ion binding]; other site 1230340006424 G-X-G motif; other site 1230340006425 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1230340006426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340006427 active site 1230340006428 phosphorylation site [posttranslational modification] 1230340006429 intermolecular recognition site; other site 1230340006430 dimerization interface [polypeptide binding]; other site 1230340006431 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1230340006432 DNA binding site [nucleotide binding] 1230340006433 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1230340006434 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1230340006435 RNA binding surface [nucleotide binding]; other site 1230340006436 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1230340006437 active site 1230340006438 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1230340006439 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1230340006440 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1230340006441 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1230340006442 active site 1230340006443 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1230340006444 substrate binding site [chemical binding]; other site 1230340006445 catalytic residues [active] 1230340006446 dimer interface [polypeptide binding]; other site 1230340006447 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1230340006448 phosphopentomutase; Provisional; Region: PRK05362 1230340006449 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1230340006450 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1230340006451 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1230340006452 active site 1230340006453 Int/Topo IB signature motif; other site 1230340006454 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1230340006455 metal binding site 2 [ion binding]; metal-binding site 1230340006456 putative DNA binding helix; other site 1230340006457 metal binding site 1 [ion binding]; metal-binding site 1230340006458 dimer interface [polypeptide binding]; other site 1230340006459 structural Zn2+ binding site [ion binding]; other site 1230340006460 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1230340006461 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1230340006462 ABC-ATPase subunit interface; other site 1230340006463 dimer interface [polypeptide binding]; other site 1230340006464 putative PBP binding regions; other site 1230340006465 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1230340006466 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1230340006467 ABC-ATPase subunit interface; other site 1230340006468 dimer interface [polypeptide binding]; other site 1230340006469 putative PBP binding regions; other site 1230340006470 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1230340006471 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1230340006472 putative ligand binding residues [chemical binding]; other site 1230340006473 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1230340006474 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1230340006475 Walker A/P-loop; other site 1230340006476 ATP binding site [chemical binding]; other site 1230340006477 Q-loop/lid; other site 1230340006478 ABC transporter signature motif; other site 1230340006479 Walker B; other site 1230340006480 D-loop; other site 1230340006481 H-loop/switch region; other site 1230340006482 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1230340006483 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1230340006484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1230340006485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1230340006486 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1230340006487 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1230340006488 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1230340006489 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1230340006490 Walker A/P-loop; other site 1230340006491 ATP binding site [chemical binding]; other site 1230340006492 Q-loop/lid; other site 1230340006493 ABC transporter signature motif; other site 1230340006494 Walker B; other site 1230340006495 D-loop; other site 1230340006496 H-loop/switch region; other site 1230340006497 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1230340006498 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1230340006499 dimer interface [polypeptide binding]; other site 1230340006500 ADP-ribose binding site [chemical binding]; other site 1230340006501 active site 1230340006502 nudix motif; other site 1230340006503 metal binding site [ion binding]; metal-binding site 1230340006504 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1230340006505 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1230340006506 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1230340006507 active site 1230340006508 DNA polymerase IV; Validated; Region: PRK02406 1230340006509 DNA binding site [nucleotide binding] 1230340006510 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1230340006511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1230340006512 NAD(P) binding site [chemical binding]; other site 1230340006513 active site 1230340006514 ribonuclease Z; Region: RNase_Z; TIGR02651 1230340006515 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1230340006516 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1230340006517 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1230340006518 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 1230340006519 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1230340006520 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1230340006521 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1230340006522 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1230340006523 PYR/PP interface [polypeptide binding]; other site 1230340006524 dimer interface [polypeptide binding]; other site 1230340006525 TPP binding site [chemical binding]; other site 1230340006526 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1230340006527 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1230340006528 TPP-binding site [chemical binding]; other site 1230340006529 dimer interface [polypeptide binding]; other site 1230340006530 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1230340006531 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1230340006532 putative valine binding site [chemical binding]; other site 1230340006533 dimer interface [polypeptide binding]; other site 1230340006534 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1230340006535 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1230340006536 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1230340006537 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1230340006538 2-isopropylmalate synthase; Validated; Region: PRK00915 1230340006539 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1230340006540 active site 1230340006541 catalytic residues [active] 1230340006542 metal binding site [ion binding]; metal-binding site 1230340006543 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1230340006544 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1230340006545 tartrate dehydrogenase; Region: TTC; TIGR02089 1230340006546 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1230340006547 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1230340006548 substrate binding site [chemical binding]; other site 1230340006549 ligand binding site [chemical binding]; other site 1230340006550 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1230340006551 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1230340006552 substrate binding site [chemical binding]; other site 1230340006553 threonine dehydratase; Validated; Region: PRK08639 1230340006554 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1230340006555 tetramer interface [polypeptide binding]; other site 1230340006556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340006557 catalytic residue [active] 1230340006558 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1230340006559 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1230340006560 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1230340006561 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1230340006562 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1230340006563 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1230340006564 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1230340006565 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1230340006566 DNA binding site [nucleotide binding] 1230340006567 domain linker motif; other site 1230340006568 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1230340006569 dimerization interface [polypeptide binding]; other site 1230340006570 ligand binding site [chemical binding]; other site 1230340006571 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1230340006572 intersubunit interface [polypeptide binding]; other site 1230340006573 active site 1230340006574 catalytic residue [active] 1230340006575 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1230340006576 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 1230340006577 non-specific DNA interactions [nucleotide binding]; other site 1230340006578 DNA binding site [nucleotide binding] 1230340006579 sequence specific DNA binding site [nucleotide binding]; other site 1230340006580 putative cAMP binding site [chemical binding]; other site 1230340006581 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1230340006582 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1230340006583 active pocket/dimerization site; other site 1230340006584 active site 1230340006585 phosphorylation site [posttranslational modification] 1230340006586 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1230340006587 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1230340006588 putative active site [active] 1230340006589 SIS domain; Region: SIS; pfam01380 1230340006590 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1230340006591 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1230340006592 dimer interface [polypeptide binding]; other site 1230340006593 active site 1230340006594 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1230340006595 dimer interface [polypeptide binding]; other site 1230340006596 active site 1230340006597 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1230340006598 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1230340006599 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1230340006600 active site 1230340006601 phosphorylation site [posttranslational modification] 1230340006602 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1230340006603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340006604 DNA-binding site [nucleotide binding]; DNA binding site 1230340006605 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1230340006606 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1230340006607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340006608 DNA-binding site [nucleotide binding]; DNA binding site 1230340006609 UTRA domain; Region: UTRA; pfam07702 1230340006610 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1230340006611 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1230340006612 active site 1230340006613 catalytic tetrad [active] 1230340006614 acetolactate synthase; Reviewed; Region: PRK08617 1230340006615 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1230340006616 PYR/PP interface [polypeptide binding]; other site 1230340006617 dimer interface [polypeptide binding]; other site 1230340006618 TPP binding site [chemical binding]; other site 1230340006619 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1230340006620 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1230340006621 TPP-binding site [chemical binding]; other site 1230340006622 dimer interface [polypeptide binding]; other site 1230340006623 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1230340006624 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1230340006625 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1230340006626 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1230340006627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340006628 dimer interface [polypeptide binding]; other site 1230340006629 conserved gate region; other site 1230340006630 ABC-ATPase subunit interface; other site 1230340006631 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1230340006632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340006633 dimer interface [polypeptide binding]; other site 1230340006634 conserved gate region; other site 1230340006635 ABC-ATPase subunit interface; other site 1230340006636 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1230340006637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340006638 active site 1230340006639 phosphorylation site [posttranslational modification] 1230340006640 intermolecular recognition site; other site 1230340006641 dimerization interface [polypeptide binding]; other site 1230340006642 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1230340006643 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1230340006644 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1230340006645 dimerization interface [polypeptide binding]; other site 1230340006646 Histidine kinase; Region: His_kinase; pfam06580 1230340006647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340006648 ATP binding site [chemical binding]; other site 1230340006649 Mg2+ binding site [ion binding]; other site 1230340006650 G-X-G motif; other site 1230340006651 Predicted integral membrane protein [Function unknown]; Region: COG5578 1230340006652 Uncharacterized conserved protein [Function unknown]; Region: COG3538 1230340006653 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1230340006654 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1230340006655 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 1230340006656 active site 1230340006657 metal binding site [ion binding]; metal-binding site 1230340006658 homodimer interface [polypeptide binding]; other site 1230340006659 catalytic site [active] 1230340006660 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1230340006661 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1230340006662 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1230340006663 active site 1230340006664 catalytic site [active] 1230340006665 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1230340006666 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1230340006667 DNA-binding site [nucleotide binding]; DNA binding site 1230340006668 RNA-binding motif; other site 1230340006669 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1230340006670 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1230340006671 active site 1230340006672 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1230340006673 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1230340006674 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1230340006675 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1230340006676 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1230340006677 active site 1230340006678 HIGH motif; other site 1230340006679 nucleotide binding site [chemical binding]; other site 1230340006680 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1230340006681 active site 1230340006682 KMSKS motif; other site 1230340006683 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1230340006684 tRNA binding surface [nucleotide binding]; other site 1230340006685 anticodon binding site; other site 1230340006686 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1230340006687 DivIVA protein; Region: DivIVA; pfam05103 1230340006688 DivIVA domain; Region: DivI1A_domain; TIGR03544 1230340006689 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1230340006690 HTH domain; Region: HTH_11; pfam08279 1230340006691 3H domain; Region: 3H; pfam02829 1230340006692 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1230340006693 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1230340006694 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1230340006695 catalytic residue [active] 1230340006696 L-aspartate oxidase; Provisional; Region: PRK08071 1230340006697 L-aspartate oxidase; Provisional; Region: PRK06175 1230340006698 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1230340006699 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1230340006700 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1230340006701 dimerization interface [polypeptide binding]; other site 1230340006702 active site 1230340006703 quinolinate synthetase; Provisional; Region: PRK09375 1230340006704 Transposase; Region: HTH_Tnp_1; cl17663 1230340006705 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1230340006706 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340006707 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340006708 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340006709 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1230340006710 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340006711 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340006712 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340006713 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340006714 Leucine rich repeat; Region: LRR_8; pfam13855 1230340006715 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340006716 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1230340006717 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340006718 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340006719 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340006720 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1230340006721 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340006722 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340006723 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340006724 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1230340006725 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1230340006726 Mga helix-turn-helix domain; Region: Mga; pfam05043 1230340006727 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1230340006728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340006729 S-adenosylmethionine binding site [chemical binding]; other site 1230340006730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1230340006731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1230340006732 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1230340006733 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1230340006734 RNA binding surface [nucleotide binding]; other site 1230340006735 YGGT family; Region: YGGT; pfam02325 1230340006736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1230340006737 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1230340006738 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1230340006739 catalytic residue [active] 1230340006740 cell division protein FtsZ; Validated; Region: PRK09330 1230340006741 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1230340006742 nucleotide binding site [chemical binding]; other site 1230340006743 SulA interaction site; other site 1230340006744 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1230340006745 Cell division protein FtsA; Region: FtsA; smart00842 1230340006746 Cell division protein FtsA; Region: FtsA; pfam14450 1230340006747 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1230340006748 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1230340006749 Cell division protein FtsQ; Region: FtsQ; pfam03799 1230340006750 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1230340006751 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1230340006752 active site 1230340006753 homodimer interface [polypeptide binding]; other site 1230340006754 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1230340006755 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1230340006756 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1230340006757 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1230340006758 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1230340006759 Mg++ binding site [ion binding]; other site 1230340006760 putative catalytic motif [active] 1230340006761 putative substrate binding site [chemical binding]; other site 1230340006762 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1230340006763 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1230340006764 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1230340006765 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1230340006766 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1230340006767 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1230340006768 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1230340006769 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1230340006770 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1230340006771 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1230340006772 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1230340006773 MraW methylase family; Region: Methyltransf_5; pfam01795 1230340006774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1230340006775 MraZ protein; Region: MraZ; pfam02381 1230340006776 MraZ protein; Region: MraZ; pfam02381 1230340006777 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1230340006778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340006779 putative substrate translocation pore; other site 1230340006780 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1230340006781 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1230340006782 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1230340006783 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1230340006784 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1230340006785 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1230340006786 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1230340006787 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1230340006788 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1230340006789 hypothetical protein; Provisional; Region: PRK13670 1230340006790 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1230340006791 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1230340006792 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1230340006793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340006794 Walker A/P-loop; other site 1230340006795 ATP binding site [chemical binding]; other site 1230340006796 Q-loop/lid; other site 1230340006797 ABC transporter signature motif; other site 1230340006798 Walker B; other site 1230340006799 D-loop; other site 1230340006800 H-loop/switch region; other site 1230340006801 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1230340006802 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1230340006803 protein binding site [polypeptide binding]; other site 1230340006804 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1230340006805 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1230340006806 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1230340006807 active site 1230340006808 (T/H)XGH motif; other site 1230340006809 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1230340006810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340006811 S-adenosylmethionine binding site [chemical binding]; other site 1230340006812 hypothetical protein; Provisional; Region: PRK02886 1230340006813 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1230340006814 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1230340006815 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1230340006816 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1230340006817 UbiA prenyltransferase family; Region: UbiA; pfam01040 1230340006818 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1230340006819 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1230340006820 Ion transport protein; Region: Ion_trans; pfam00520 1230340006821 Ion channel; Region: Ion_trans_2; pfam07885 1230340006822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1230340006823 MOSC domain; Region: MOSC; pfam03473 1230340006824 3-alpha domain; Region: 3-alpha; pfam03475 1230340006825 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1230340006826 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1230340006827 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1230340006828 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 1230340006829 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1230340006830 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1230340006831 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1230340006832 active site 1230340006833 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1230340006834 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1230340006835 ring oligomerisation interface [polypeptide binding]; other site 1230340006836 ATP/Mg binding site [chemical binding]; other site 1230340006837 stacking interactions; other site 1230340006838 hinge regions; other site 1230340006839 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1230340006840 oligomerisation interface [polypeptide binding]; other site 1230340006841 mobile loop; other site 1230340006842 roof hairpin; other site 1230340006843 CAAX protease self-immunity; Region: Abi; pfam02517 1230340006844 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1230340006845 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1230340006846 CoA binding domain; Region: CoA_binding; pfam02629 1230340006847 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1230340006848 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1230340006849 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1230340006850 ABC transporter; Region: ABC_tran_2; pfam12848 1230340006851 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1230340006852 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1230340006853 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1230340006854 UGMP family protein; Validated; Region: PRK09604 1230340006855 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1230340006856 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1230340006857 Glycoprotease family; Region: Peptidase_M22; pfam00814 1230340006858 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1230340006859 camphor resistance protein CrcB; Provisional; Region: PRK14214 1230340006860 camphor resistance protein CrcB; Provisional; Region: PRK14231 1230340006861 Uncharacterized conserved protein [Function unknown]; Region: COG4832 1230340006862 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1230340006863 Phosphotransferase enzyme family; Region: APH; pfam01636 1230340006864 substrate binding site [chemical binding]; other site 1230340006865 Phosphotransferase enzyme family; Region: APH; pfam01636 1230340006866 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1230340006867 active site 1230340006868 ATP binding site [chemical binding]; other site 1230340006869 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340006870 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340006871 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340006872 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340006873 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340006874 non-specific DNA binding site [nucleotide binding]; other site 1230340006875 salt bridge; other site 1230340006876 sequence-specific DNA binding site [nucleotide binding]; other site 1230340006877 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 1230340006878 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1230340006879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1230340006880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1230340006881 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1230340006882 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1230340006883 substrate binding pocket [chemical binding]; other site 1230340006884 argininosuccinate synthase; Provisional; Region: PRK13820 1230340006885 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1230340006886 ANP binding site [chemical binding]; other site 1230340006887 Substrate Binding Site II [chemical binding]; other site 1230340006888 Substrate Binding Site I [chemical binding]; other site 1230340006889 argininosuccinate lyase; Provisional; Region: PRK00855 1230340006890 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1230340006891 active sites [active] 1230340006892 tetramer interface [polypeptide binding]; other site 1230340006893 BCCT family transporter; Region: BCCT; pfam02028 1230340006894 hypothetical protein; Provisional; Region: PRK06357 1230340006895 active site 1230340006896 intersubunit interface [polypeptide binding]; other site 1230340006897 Zn2+ binding site [ion binding]; other site 1230340006898 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1230340006899 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1230340006900 putative substrate binding site [chemical binding]; other site 1230340006901 putative ATP binding site [chemical binding]; other site 1230340006902 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1230340006903 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1230340006904 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1230340006905 active site 1230340006906 P-loop; other site 1230340006907 phosphorylation site [posttranslational modification] 1230340006908 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340006909 active site 1230340006910 phosphorylation site [posttranslational modification] 1230340006911 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1230340006912 PRD domain; Region: PRD; pfam00874 1230340006913 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1230340006914 active site 1230340006915 P-loop; other site 1230340006916 phosphorylation site [posttranslational modification] 1230340006917 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 1230340006918 active site 1230340006919 phosphorylation site [posttranslational modification] 1230340006920 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1230340006921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340006922 DNA-binding site [nucleotide binding]; DNA binding site 1230340006923 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1230340006924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340006925 homodimer interface [polypeptide binding]; other site 1230340006926 catalytic residue [active] 1230340006927 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1230340006928 phosphate binding site [ion binding]; other site 1230340006929 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 1230340006930 conserved cys residue [active] 1230340006931 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1230340006932 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1230340006933 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1230340006934 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1230340006935 G1 box; other site 1230340006936 GTP/Mg2+ binding site [chemical binding]; other site 1230340006937 Switch I region; other site 1230340006938 G2 box; other site 1230340006939 G3 box; other site 1230340006940 Switch II region; other site 1230340006941 G4 box; other site 1230340006942 G5 box; other site 1230340006943 Nucleoside recognition; Region: Gate; pfam07670 1230340006944 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1230340006945 Nucleoside recognition; Region: Gate; pfam07670 1230340006946 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1230340006947 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1230340006948 putative active site [active] 1230340006949 putative metal binding site [ion binding]; other site 1230340006950 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1230340006951 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1230340006952 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1230340006953 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1230340006954 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1230340006955 active site 1230340006956 dimer interface [polypeptide binding]; other site 1230340006957 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1230340006958 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1230340006959 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1230340006960 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1230340006961 dimer interface [polypeptide binding]; other site 1230340006962 FMN binding site [chemical binding]; other site 1230340006963 NADPH bind site [chemical binding]; other site 1230340006964 Helix-turn-helix domain; Region: HTH_17; pfam12728 1230340006965 putative heme peroxidase; Provisional; Region: PRK12276 1230340006966 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1230340006967 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1230340006968 Walker A/P-loop; other site 1230340006969 ATP binding site [chemical binding]; other site 1230340006970 Q-loop/lid; other site 1230340006971 ABC transporter signature motif; other site 1230340006972 Walker B; other site 1230340006973 D-loop; other site 1230340006974 H-loop/switch region; other site 1230340006975 FtsX-like permease family; Region: FtsX; pfam02687 1230340006976 FtsX-like permease family; Region: FtsX; pfam02687 1230340006977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340006978 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1230340006979 Coenzyme A binding pocket [chemical binding]; other site 1230340006980 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1230340006981 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1230340006982 active site 1230340006983 substrate binding site [chemical binding]; other site 1230340006984 metal binding site [ion binding]; metal-binding site 1230340006985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1230340006986 YbbR-like protein; Region: YbbR; pfam07949 1230340006987 YbbR-like protein; Region: YbbR; pfam07949 1230340006988 YbbR-like protein; Region: YbbR; pfam07949 1230340006989 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1230340006990 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1230340006991 maltose phosphorylase; Provisional; Region: PRK13807 1230340006992 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1230340006993 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1230340006994 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1230340006995 Predicted integral membrane protein [Function unknown]; Region: COG5521 1230340006996 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1230340006997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340006998 dimer interface [polypeptide binding]; other site 1230340006999 conserved gate region; other site 1230340007000 putative PBP binding loops; other site 1230340007001 ABC-ATPase subunit interface; other site 1230340007002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340007003 dimer interface [polypeptide binding]; other site 1230340007004 conserved gate region; other site 1230340007005 putative PBP binding loops; other site 1230340007006 ABC-ATPase subunit interface; other site 1230340007007 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1230340007008 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1230340007009 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1230340007010 homodimer interface [polypeptide binding]; other site 1230340007011 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1230340007012 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1230340007013 active site 1230340007014 homodimer interface [polypeptide binding]; other site 1230340007015 catalytic site [active] 1230340007016 CAAX protease self-immunity; Region: Abi; cl00558 1230340007017 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1230340007018 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1230340007019 DNA binding site [nucleotide binding] 1230340007020 domain linker motif; other site 1230340007021 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1230340007022 ligand binding site [chemical binding]; other site 1230340007023 dimerization interface [polypeptide binding]; other site 1230340007024 Amino acid permease; Region: AA_permease_2; pfam13520 1230340007025 K+ potassium transporter; Region: K_trans; cl15781 1230340007026 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340007027 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1230340007028 ligand binding site [chemical binding]; other site 1230340007029 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340007030 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1230340007031 ligand binding site [chemical binding]; other site 1230340007032 flexible hinge region; other site 1230340007033 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1230340007034 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1230340007035 intersubunit interface [polypeptide binding]; other site 1230340007036 active site 1230340007037 zinc binding site [ion binding]; other site 1230340007038 Na+ binding site [ion binding]; other site 1230340007039 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1230340007040 intersubunit interface [polypeptide binding]; other site 1230340007041 active site 1230340007042 zinc binding site [ion binding]; other site 1230340007043 Na+ binding site [ion binding]; other site 1230340007044 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1230340007045 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1230340007046 active site 1230340007047 P-loop; other site 1230340007048 phosphorylation site [posttranslational modification] 1230340007049 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340007050 active site 1230340007051 phosphorylation site [posttranslational modification] 1230340007052 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1230340007053 HTH domain; Region: HTH_11; pfam08279 1230340007054 Mga helix-turn-helix domain; Region: Mga; pfam05043 1230340007055 PRD domain; Region: PRD; pfam00874 1230340007056 PRD domain; Region: PRD; pfam00874 1230340007057 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1230340007058 active site 1230340007059 P-loop; other site 1230340007060 phosphorylation site [posttranslational modification] 1230340007061 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1230340007062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340007063 Walker A/P-loop; other site 1230340007064 ATP binding site [chemical binding]; other site 1230340007065 Q-loop/lid; other site 1230340007066 ABC transporter signature motif; other site 1230340007067 Walker B; other site 1230340007068 D-loop; other site 1230340007069 H-loop/switch region; other site 1230340007070 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1230340007071 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1230340007072 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1230340007073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340007074 Coenzyme A binding pocket [chemical binding]; other site 1230340007075 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1230340007076 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1230340007077 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1230340007078 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1230340007079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1230340007080 DNA-binding site [nucleotide binding]; DNA binding site 1230340007081 UTRA domain; Region: UTRA; pfam07702 1230340007082 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1230340007083 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1230340007084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1230340007085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1230340007086 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1230340007087 putative dimerization interface [polypeptide binding]; other site 1230340007088 Predicted membrane protein [Function unknown]; Region: COG2855 1230340007089 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 1230340007090 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1230340007091 putative metal binding site [ion binding]; other site 1230340007092 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1230340007093 homodimer interface [polypeptide binding]; other site 1230340007094 chemical substrate binding site [chemical binding]; other site 1230340007095 oligomer interface [polypeptide binding]; other site 1230340007096 metal binding site [ion binding]; metal-binding site 1230340007097 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1230340007098 catalytic residues [active] 1230340007099 flavodoxin; Provisional; Region: PRK09271 1230340007100 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1230340007101 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1230340007102 dimer interface [polypeptide binding]; other site 1230340007103 putative radical transfer pathway; other site 1230340007104 diiron center [ion binding]; other site 1230340007105 tyrosyl radical; other site 1230340007106 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 1230340007107 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1230340007108 active site 1230340007109 dimer interface [polypeptide binding]; other site 1230340007110 catalytic residues [active] 1230340007111 effector binding site; other site 1230340007112 R2 peptide binding site; other site 1230340007113 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1230340007114 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1230340007115 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1230340007116 CsbD-like; Region: CsbD; cl17424 1230340007117 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1230340007118 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1230340007119 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1230340007120 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1230340007121 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1230340007122 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1230340007123 conserved cys residue [active] 1230340007124 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1230340007125 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1230340007126 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1230340007127 Cupin; Region: Cupin_1; pfam00190 1230340007128 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1230340007129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1230340007130 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340007131 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340007132 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1230340007133 ligand binding site [chemical binding]; other site 1230340007134 flexible hinge region; other site 1230340007135 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1230340007136 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1230340007137 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1230340007138 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1230340007139 dimer interface [polypeptide binding]; other site 1230340007140 active site 1230340007141 metal binding site [ion binding]; metal-binding site 1230340007142 glutathione binding site [chemical binding]; other site 1230340007143 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1230340007144 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1230340007145 FMN binding site [chemical binding]; other site 1230340007146 substrate binding site [chemical binding]; other site 1230340007147 putative catalytic residue [active] 1230340007148 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1230340007149 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1230340007150 Coenzyme A transferase; Region: CoA_trans; smart00882 1230340007151 Coenzyme A transferase; Region: CoA_trans; cl17247 1230340007152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340007153 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1230340007154 Walker A motif; other site 1230340007155 ATP binding site [chemical binding]; other site 1230340007156 Walker B motif; other site 1230340007157 arginine finger; other site 1230340007158 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1230340007159 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1230340007160 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1230340007161 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1230340007162 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1230340007163 metal binding site [ion binding]; metal-binding site 1230340007164 active site 1230340007165 I-site; other site 1230340007166 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1230340007167 classical (c) SDRs; Region: SDR_c; cd05233 1230340007168 NAD(P) binding site [chemical binding]; other site 1230340007169 active site 1230340007170 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1230340007171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1230340007172 Tic20-like protein; Region: Tic20; pfam09685 1230340007173 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1230340007174 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340007175 Collagen binding domain; Region: Collagen_bind; pfam05737 1230340007176 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340007177 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340007178 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340007179 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340007180 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340007181 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1230340007182 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340007183 Collagen binding domain; Region: Collagen_bind; pfam05737 1230340007184 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340007185 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340007186 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340007187 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340007188 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340007189 Cna protein B-type domain; Region: Cna_B; pfam05738 1230340007190 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340007191 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340007192 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340007193 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340007194 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340007195 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1230340007196 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1230340007197 active site 1230340007198 catalytic site [active] 1230340007199 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1230340007200 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1230340007201 Walker A/P-loop; other site 1230340007202 ATP binding site [chemical binding]; other site 1230340007203 Q-loop/lid; other site 1230340007204 ABC transporter signature motif; other site 1230340007205 Walker B; other site 1230340007206 D-loop; other site 1230340007207 H-loop/switch region; other site 1230340007208 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1230340007209 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1230340007210 ABC-ATPase subunit interface; other site 1230340007211 dimer interface [polypeptide binding]; other site 1230340007212 putative PBP binding regions; other site 1230340007213 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 1230340007214 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1230340007215 intersubunit interface [polypeptide binding]; other site 1230340007216 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1230340007217 heme-binding site [chemical binding]; other site 1230340007218 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 1230340007219 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1230340007220 heme-binding site [chemical binding]; other site 1230340007221 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1230340007222 heme-binding site [chemical binding]; other site 1230340007223 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 1230340007224 heme uptake protein IsdC; Region: IsdC; TIGR03656 1230340007225 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1230340007226 heme-binding site [chemical binding]; other site 1230340007227 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 1230340007228 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 1230340007229 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1230340007230 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1230340007231 active site 1230340007232 Zn binding site [ion binding]; other site 1230340007233 Competence protein CoiA-like family; Region: CoiA; cl11541 1230340007234 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 1230340007235 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1230340007236 ArsC family; Region: ArsC; pfam03960 1230340007237 putative catalytic residues [active] 1230340007238 thiol/disulfide switch; other site 1230340007239 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1230340007240 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1230340007241 Walker A/P-loop; other site 1230340007242 ATP binding site [chemical binding]; other site 1230340007243 Q-loop/lid; other site 1230340007244 ABC transporter signature motif; other site 1230340007245 Walker B; other site 1230340007246 D-loop; other site 1230340007247 H-loop/switch region; other site 1230340007248 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1230340007249 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1230340007250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340007251 dimer interface [polypeptide binding]; other site 1230340007252 conserved gate region; other site 1230340007253 putative PBP binding loops; other site 1230340007254 ABC-ATPase subunit interface; other site 1230340007255 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1230340007256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340007257 dimer interface [polypeptide binding]; other site 1230340007258 conserved gate region; other site 1230340007259 putative PBP binding loops; other site 1230340007260 ABC-ATPase subunit interface; other site 1230340007261 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1230340007262 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1230340007263 peptide binding site [polypeptide binding]; other site 1230340007264 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1230340007265 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1230340007266 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1230340007267 active site 1230340007268 HIGH motif; other site 1230340007269 dimer interface [polypeptide binding]; other site 1230340007270 KMSKS motif; other site 1230340007271 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1230340007272 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1230340007273 MarR family; Region: MarR; pfam01047 1230340007274 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1230340007275 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1230340007276 dimer interface [polypeptide binding]; other site 1230340007277 active site 1230340007278 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1230340007279 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1230340007280 dimer interface [polypeptide binding]; other site 1230340007281 active site 1230340007282 CoA binding pocket [chemical binding]; other site 1230340007283 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1230340007284 SH3-like domain; Region: SH3_8; pfam13457 1230340007285 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1230340007286 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1230340007287 catalytic core [active] 1230340007288 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1230340007289 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1230340007290 Clp amino terminal domain; Region: Clp_N; pfam02861 1230340007291 Clp amino terminal domain; Region: Clp_N; pfam02861 1230340007292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340007293 Walker A motif; other site 1230340007294 ATP binding site [chemical binding]; other site 1230340007295 Walker B motif; other site 1230340007296 arginine finger; other site 1230340007297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340007298 Walker A motif; other site 1230340007299 ATP binding site [chemical binding]; other site 1230340007300 Walker B motif; other site 1230340007301 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1230340007302 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1230340007303 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1230340007304 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1230340007305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340007306 active site 1230340007307 motif I; other site 1230340007308 motif II; other site 1230340007309 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1230340007310 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1230340007311 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1230340007312 ferrochelatase; Provisional; Region: PRK12435 1230340007313 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1230340007314 C-terminal domain interface [polypeptide binding]; other site 1230340007315 active site 1230340007316 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1230340007317 active site 1230340007318 N-terminal domain interface [polypeptide binding]; other site 1230340007319 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1230340007320 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1230340007321 substrate binding site [chemical binding]; other site 1230340007322 active site 1230340007323 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1230340007324 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1230340007325 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1230340007326 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1230340007327 Walker A/P-loop; other site 1230340007328 ATP binding site [chemical binding]; other site 1230340007329 Q-loop/lid; other site 1230340007330 ABC transporter signature motif; other site 1230340007331 Walker B; other site 1230340007332 D-loop; other site 1230340007333 H-loop/switch region; other site 1230340007334 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1230340007335 HIT family signature motif; other site 1230340007336 catalytic residue [active] 1230340007337 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1230340007338 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1230340007339 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1230340007340 SurA N-terminal domain; Region: SurA_N_3; cl07813 1230340007341 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1230340007342 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1230340007343 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1230340007344 generic binding surface II; other site 1230340007345 generic binding surface I; other site 1230340007346 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1230340007347 Zn2+ binding site [ion binding]; other site 1230340007348 Mg2+ binding site [ion binding]; other site 1230340007349 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1230340007350 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1230340007351 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1230340007352 active site 1230340007353 metal binding site [ion binding]; metal-binding site 1230340007354 DNA binding site [nucleotide binding] 1230340007355 hypothetical protein; Provisional; Region: PRK13676 1230340007356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1230340007357 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1230340007358 Class II fumarases; Region: Fumarase_classII; cd01362 1230340007359 active site 1230340007360 tetramer interface [polypeptide binding]; other site 1230340007361 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1230340007362 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1230340007363 Walker A/P-loop; other site 1230340007364 ATP binding site [chemical binding]; other site 1230340007365 Q-loop/lid; other site 1230340007366 ABC transporter signature motif; other site 1230340007367 Walker B; other site 1230340007368 D-loop; other site 1230340007369 H-loop/switch region; other site 1230340007370 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1230340007371 Transglycosylase; Region: Transgly; pfam00912 1230340007372 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1230340007373 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1230340007374 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1230340007375 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1230340007376 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1230340007377 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1230340007378 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1230340007379 Domain of unknown function DUF21; Region: DUF21; pfam01595 1230340007380 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1230340007381 Transporter associated domain; Region: CorC_HlyC; smart01091 1230340007382 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1230340007383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1230340007384 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1230340007385 putative dimerization interface [polypeptide binding]; other site 1230340007386 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1230340007387 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1230340007388 active site 1230340007389 FMN binding site [chemical binding]; other site 1230340007390 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1230340007391 substrate binding site [chemical binding]; other site 1230340007392 putative catalytic residue [active] 1230340007393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1230340007394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1230340007395 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1230340007396 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1230340007397 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1230340007398 shikimate binding site; other site 1230340007399 NAD(P) binding site [chemical binding]; other site 1230340007400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340007401 putative substrate translocation pore; other site 1230340007402 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1230340007403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340007404 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1230340007405 putative substrate translocation pore; other site 1230340007406 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1230340007407 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1230340007408 Walker A/P-loop; other site 1230340007409 ATP binding site [chemical binding]; other site 1230340007410 Q-loop/lid; other site 1230340007411 ABC transporter signature motif; other site 1230340007412 Walker B; other site 1230340007413 D-loop; other site 1230340007414 H-loop/switch region; other site 1230340007415 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1230340007416 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1230340007417 DNA binding site [nucleotide binding] 1230340007418 active site 1230340007419 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1230340007420 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1230340007421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1230340007422 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1230340007423 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1230340007424 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1230340007425 active site 1230340007426 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1230340007427 putative dimer interface [polypeptide binding]; other site 1230340007428 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1230340007429 ligand binding site [chemical binding]; other site 1230340007430 Zn binding site [ion binding]; other site 1230340007431 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1230340007432 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1230340007433 active site 1230340007434 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1230340007435 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1230340007436 active site 1230340007437 catalytic tetrad [active] 1230340007438 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1230340007439 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1230340007440 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1230340007441 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1230340007442 substrate binding pocket [chemical binding]; other site 1230340007443 membrane-bound complex binding site; other site 1230340007444 hinge residues; other site 1230340007445 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1230340007446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340007447 dimer interface [polypeptide binding]; other site 1230340007448 conserved gate region; other site 1230340007449 putative PBP binding loops; other site 1230340007450 ABC-ATPase subunit interface; other site 1230340007451 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1230340007452 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1230340007453 Walker A/P-loop; other site 1230340007454 ATP binding site [chemical binding]; other site 1230340007455 Q-loop/lid; other site 1230340007456 ABC transporter signature motif; other site 1230340007457 Walker B; other site 1230340007458 D-loop; other site 1230340007459 H-loop/switch region; other site 1230340007460 aspartate aminotransferase; Provisional; Region: PRK06348 1230340007461 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1230340007462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340007463 homodimer interface [polypeptide binding]; other site 1230340007464 catalytic residue [active] 1230340007465 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1230340007466 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1230340007467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340007468 motif II; other site 1230340007469 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1230340007470 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1230340007471 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1230340007472 proposed catalytic triad [active] 1230340007473 conserved cys residue [active] 1230340007474 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1230340007475 methionine cluster; other site 1230340007476 active site 1230340007477 phosphorylation site [posttranslational modification] 1230340007478 metal binding site [ion binding]; metal-binding site 1230340007479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340007480 Coenzyme A binding pocket [chemical binding]; other site 1230340007481 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1230340007482 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1230340007483 esterase; Provisional; Region: PRK10566 1230340007484 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1230340007485 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1230340007486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1230340007487 motif II; other site 1230340007488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340007489 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1230340007490 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1230340007491 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1230340007492 hypothetical protein; Provisional; Region: PRK13673 1230340007493 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1230340007494 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1230340007495 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1230340007496 Part of AAA domain; Region: AAA_19; pfam13245 1230340007497 Family description; Region: UvrD_C_2; pfam13538 1230340007498 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1230340007499 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1230340007500 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1230340007501 IDEAL domain; Region: IDEAL; pfam08858 1230340007502 ComK protein; Region: ComK; cl11560 1230340007503 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1230340007504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340007505 non-specific DNA binding site [nucleotide binding]; other site 1230340007506 salt bridge; other site 1230340007507 sequence-specific DNA binding site [nucleotide binding]; other site 1230340007508 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1230340007509 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340007510 active site 1230340007511 phosphorylation site [posttranslational modification] 1230340007512 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1230340007513 active site 1230340007514 P-loop; other site 1230340007515 phosphorylation site [posttranslational modification] 1230340007516 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1230340007517 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1230340007518 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1230340007519 putative substrate binding site [chemical binding]; other site 1230340007520 putative ATP binding site [chemical binding]; other site 1230340007521 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1230340007522 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1230340007523 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1230340007524 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1230340007525 trimer interface [polypeptide binding]; other site 1230340007526 active site 1230340007527 G bulge; other site 1230340007528 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1230340007529 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1230340007530 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1230340007531 non-specific DNA interactions [nucleotide binding]; other site 1230340007532 DNA binding site [nucleotide binding] 1230340007533 sequence specific DNA binding site [nucleotide binding]; other site 1230340007534 putative cAMP binding site [chemical binding]; other site 1230340007535 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1230340007536 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1230340007537 substrate binding site [chemical binding]; other site 1230340007538 ATP binding site [chemical binding]; other site 1230340007539 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1230340007540 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1230340007541 RNA binding surface [nucleotide binding]; other site 1230340007542 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1230340007543 active site 1230340007544 uracil binding [chemical binding]; other site 1230340007545 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1230340007546 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1230340007547 active site 1230340007548 non-prolyl cis peptide bond; other site 1230340007549 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1230340007550 catalytic residues [active] 1230340007551 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1230340007552 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1230340007553 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1230340007554 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1230340007555 Walker A/P-loop; other site 1230340007556 ATP binding site [chemical binding]; other site 1230340007557 Q-loop/lid; other site 1230340007558 ABC transporter signature motif; other site 1230340007559 Walker B; other site 1230340007560 D-loop; other site 1230340007561 H-loop/switch region; other site 1230340007562 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1230340007563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340007564 dimer interface [polypeptide binding]; other site 1230340007565 conserved gate region; other site 1230340007566 putative PBP binding loops; other site 1230340007567 ABC-ATPase subunit interface; other site 1230340007568 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1230340007569 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1230340007570 substrate binding pocket [chemical binding]; other site 1230340007571 membrane-bound complex binding site; other site 1230340007572 hinge residues; other site 1230340007573 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340007574 Coenzyme A binding pocket [chemical binding]; other site 1230340007575 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1230340007576 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1230340007577 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1230340007578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1230340007579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1230340007580 dimerization interface [polypeptide binding]; other site 1230340007581 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1230340007582 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1230340007583 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1230340007584 active site 1230340007585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340007586 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1230340007587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340007588 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1230340007589 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1230340007590 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1230340007591 active site 1230340007592 trimer interface [polypeptide binding]; other site 1230340007593 allosteric site; other site 1230340007594 active site lid [active] 1230340007595 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1230340007596 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1230340007597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1230340007598 Predicted membrane protein [Function unknown]; Region: COG1511 1230340007599 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1230340007600 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1230340007601 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1230340007602 Predicted transcriptional regulator [Transcription]; Region: COG1959 1230340007603 Transcriptional regulator; Region: Rrf2; pfam02082 1230340007604 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 1230340007605 L-tyrosine decarboxylase; Provisional; Region: PRK13520 1230340007606 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1230340007607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340007608 catalytic residue [active] 1230340007609 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 1230340007610 Mga helix-turn-helix domain; Region: Mga; pfam05043 1230340007611 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 1230340007612 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1230340007613 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1230340007614 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1230340007615 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1230340007616 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1230340007617 active site 1230340007618 dimer interface [polypeptide binding]; other site 1230340007619 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1230340007620 dimer interface [polypeptide binding]; other site 1230340007621 active site 1230340007622 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1230340007623 nudix motif; other site 1230340007624 general stress protein 13; Validated; Region: PRK08059 1230340007625 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1230340007626 RNA binding site [nucleotide binding]; other site 1230340007627 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1230340007628 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1230340007629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340007630 homodimer interface [polypeptide binding]; other site 1230340007631 catalytic residue [active] 1230340007632 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1230340007633 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1230340007634 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1230340007635 Walker A/P-loop; other site 1230340007636 ATP binding site [chemical binding]; other site 1230340007637 Q-loop/lid; other site 1230340007638 ABC transporter signature motif; other site 1230340007639 Walker B; other site 1230340007640 D-loop; other site 1230340007641 H-loop/switch region; other site 1230340007642 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1230340007643 active site 1230340007644 P-loop; other site 1230340007645 phosphorylation site [posttranslational modification] 1230340007646 aspartate kinase; Reviewed; Region: PRK09034 1230340007647 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1230340007648 putative catalytic residues [active] 1230340007649 putative nucleotide binding site [chemical binding]; other site 1230340007650 putative aspartate binding site [chemical binding]; other site 1230340007651 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1230340007652 allosteric regulatory residue; other site 1230340007653 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1230340007654 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1230340007655 putative active site [active] 1230340007656 putative NTP binding site [chemical binding]; other site 1230340007657 putative nucleic acid binding site [nucleotide binding]; other site 1230340007658 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1230340007659 active site 1230340007660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340007661 putative substrate translocation pore; other site 1230340007662 drug efflux system protein MdtG; Provisional; Region: PRK09874 1230340007663 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1230340007664 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1230340007665 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1230340007666 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1230340007667 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1230340007668 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1230340007669 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1230340007670 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1230340007671 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1230340007672 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 1230340007673 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1230340007674 CoenzymeA binding site [chemical binding]; other site 1230340007675 subunit interaction site [polypeptide binding]; other site 1230340007676 PHB binding site; other site 1230340007677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 1230340007678 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1230340007679 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1230340007680 Cl- selectivity filter; other site 1230340007681 Cl- binding residues [ion binding]; other site 1230340007682 pore gating glutamate residue; other site 1230340007683 dimer interface [polypeptide binding]; other site 1230340007684 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340007685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1230340007686 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1230340007687 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1230340007688 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1230340007689 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1230340007690 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1230340007691 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1230340007692 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1230340007693 NAD(P) binding site [chemical binding]; other site 1230340007694 putative active site [active] 1230340007695 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1230340007696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1230340007697 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1230340007698 Leucine-rich repeats; other site 1230340007699 Substrate binding site [chemical binding]; other site 1230340007700 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340007701 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340007702 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340007703 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340007704 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340007705 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340007706 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340007707 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340007708 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1230340007709 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1230340007710 tetramer interfaces [polypeptide binding]; other site 1230340007711 binuclear metal-binding site [ion binding]; other site 1230340007712 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1230340007713 Domain of unknown function DUF21; Region: DUF21; pfam01595 1230340007714 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1230340007715 Transporter associated domain; Region: CorC_HlyC; smart01091 1230340007716 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1230340007717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340007718 Coenzyme A binding pocket [chemical binding]; other site 1230340007719 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1230340007720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340007721 active site 1230340007722 motif I; other site 1230340007723 motif II; other site 1230340007724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340007725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 1230340007726 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1230340007727 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1230340007728 active site 1230340007729 metal binding site [ion binding]; metal-binding site 1230340007730 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1230340007731 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1230340007732 Predicted membrane protein [Function unknown]; Region: COG4272 1230340007733 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1230340007734 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1230340007735 FeS assembly protein SufB; Region: sufB; TIGR01980 1230340007736 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1230340007737 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1230340007738 trimerization site [polypeptide binding]; other site 1230340007739 active site 1230340007740 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1230340007741 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1230340007742 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1230340007743 catalytic residue [active] 1230340007744 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1230340007745 FeS assembly protein SufD; Region: sufD; TIGR01981 1230340007746 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1230340007747 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1230340007748 Walker A/P-loop; other site 1230340007749 ATP binding site [chemical binding]; other site 1230340007750 Q-loop/lid; other site 1230340007751 ABC transporter signature motif; other site 1230340007752 Walker B; other site 1230340007753 D-loop; other site 1230340007754 H-loop/switch region; other site 1230340007755 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1230340007756 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1230340007757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340007758 ABC-ATPase subunit interface; other site 1230340007759 putative PBP binding loops; other site 1230340007760 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1230340007761 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1230340007762 Walker A/P-loop; other site 1230340007763 ATP binding site [chemical binding]; other site 1230340007764 Q-loop/lid; other site 1230340007765 ABC transporter signature motif; other site 1230340007766 Walker B; other site 1230340007767 D-loop; other site 1230340007768 H-loop/switch region; other site 1230340007769 NIL domain; Region: NIL; pfam09383 1230340007770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1230340007771 dimer interface [polypeptide binding]; other site 1230340007772 phosphorylation site [posttranslational modification] 1230340007773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340007774 ATP binding site [chemical binding]; other site 1230340007775 Mg2+ binding site [ion binding]; other site 1230340007776 G-X-G motif; other site 1230340007777 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1230340007778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340007779 active site 1230340007780 phosphorylation site [posttranslational modification] 1230340007781 intermolecular recognition site; other site 1230340007782 dimerization interface [polypeptide binding]; other site 1230340007783 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1230340007784 DNA binding site [nucleotide binding] 1230340007785 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1230340007786 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1230340007787 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1230340007788 catalytic residues [active] 1230340007789 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1230340007790 lipoyl attachment site [posttranslational modification]; other site 1230340007791 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1230340007792 ArsC family; Region: ArsC; pfam03960 1230340007793 putative ArsC-like catalytic residues; other site 1230340007794 putative TRX-like catalytic residues [active] 1230340007795 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1230340007796 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1230340007797 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1230340007798 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1230340007799 ABC-ATPase subunit interface; other site 1230340007800 dimer interface [polypeptide binding]; other site 1230340007801 putative PBP binding regions; other site 1230340007802 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1230340007803 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1230340007804 intersubunit interface [polypeptide binding]; other site 1230340007805 Predicted esterase [General function prediction only]; Region: COG0627 1230340007806 S-formylglutathione hydrolase; Region: PLN02442 1230340007807 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1230340007808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340007809 catalytic residue [active] 1230340007810 SdpI/YhfL protein family; Region: SdpI; pfam13630 1230340007811 CAT RNA binding domain; Region: CAT_RBD; smart01061 1230340007812 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1230340007813 PRD domain; Region: PRD; pfam00874 1230340007814 PRD domain; Region: PRD; pfam00874 1230340007815 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1230340007816 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1230340007817 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1230340007818 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1230340007819 Predicted transcriptional regulator [Transcription]; Region: COG2378 1230340007820 HTH domain; Region: HTH_11; pfam08279 1230340007821 WYL domain; Region: WYL; pfam13280 1230340007822 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1230340007823 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1230340007824 putative active site [active] 1230340007825 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1230340007826 Leucine rich repeat; Region: LRR_8; pfam13855 1230340007827 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1230340007828 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 1230340007829 active site 1230340007830 catalytic site [active] 1230340007831 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1230340007832 putative metal binding site [ion binding]; other site 1230340007833 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1230340007834 putative metal binding site [ion binding]; other site 1230340007835 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1230340007836 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1230340007837 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1230340007838 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1230340007839 active site 1230340007840 catalytic site [active] 1230340007841 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1230340007842 putative metal binding site [ion binding]; other site 1230340007843 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340007844 non-specific DNA binding site [nucleotide binding]; other site 1230340007845 salt bridge; other site 1230340007846 sequence-specific DNA binding site [nucleotide binding]; other site 1230340007847 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1230340007848 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1230340007849 SmpB-tmRNA interface; other site 1230340007850 ribonuclease R; Region: RNase_R; TIGR02063 1230340007851 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1230340007852 RNB domain; Region: RNB; pfam00773 1230340007853 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1230340007854 RNA binding site [nucleotide binding]; other site 1230340007855 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1230340007856 Esterase/lipase [General function prediction only]; Region: COG1647 1230340007857 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1230340007858 Preprotein translocase SecG subunit; Region: SecG; cl09123 1230340007859 Esterase/lipase [General function prediction only]; Region: COG1647 1230340007860 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1230340007861 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1230340007862 PGAP1-like protein; Region: PGAP1; pfam07819 1230340007863 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1230340007864 enolase; Provisional; Region: eno; PRK00077 1230340007865 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1230340007866 dimer interface [polypeptide binding]; other site 1230340007867 metal binding site [ion binding]; metal-binding site 1230340007868 substrate binding pocket [chemical binding]; other site 1230340007869 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1230340007870 phosphoglyceromutase; Provisional; Region: PRK05434 1230340007871 triosephosphate isomerase; Provisional; Region: PRK14567 1230340007872 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1230340007873 substrate binding site [chemical binding]; other site 1230340007874 dimer interface [polypeptide binding]; other site 1230340007875 catalytic triad [active] 1230340007876 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1230340007877 Phosphoglycerate kinase; Region: PGK; pfam00162 1230340007878 substrate binding site [chemical binding]; other site 1230340007879 hinge regions; other site 1230340007880 ADP binding site [chemical binding]; other site 1230340007881 catalytic site [active] 1230340007882 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1230340007883 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1230340007884 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1230340007885 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1230340007886 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1230340007887 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1230340007888 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1230340007889 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1230340007890 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1230340007891 DNA binding site [nucleotide binding] 1230340007892 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1230340007893 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1230340007894 active site 1230340007895 dimer interface [polypeptide binding]; other site 1230340007896 MMPL family; Region: MMPL; pfam03176 1230340007897 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1230340007898 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1230340007899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1230340007900 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1230340007901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 1230340007902 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1230340007903 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1230340007904 Interdomain contacts; other site 1230340007905 Cytokine receptor motif; other site 1230340007906 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1230340007907 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1230340007908 Interdomain contacts; other site 1230340007909 Cytokine receptor motif; other site 1230340007910 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1230340007911 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1230340007912 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1230340007913 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1230340007914 Clp protease; Region: CLP_protease; pfam00574 1230340007915 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1230340007916 oligomer interface [polypeptide binding]; other site 1230340007917 active site residues [active] 1230340007918 amino acid transporter; Region: 2A0306; TIGR00909 1230340007919 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1230340007920 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1230340007921 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1230340007922 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340007923 Substrate binding site [chemical binding]; other site 1230340007924 Leucine rich repeat; Region: LRR_8; pfam13855 1230340007925 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340007926 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1230340007927 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1230340007928 active site 1230340007929 FMN binding site [chemical binding]; other site 1230340007930 substrate binding site [chemical binding]; other site 1230340007931 homotetramer interface [polypeptide binding]; other site 1230340007932 catalytic residue [active] 1230340007933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1230340007934 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1230340007935 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1230340007936 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1230340007937 phosphate binding site [ion binding]; other site 1230340007938 putative substrate binding pocket [chemical binding]; other site 1230340007939 dimer interface [polypeptide binding]; other site 1230340007940 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1230340007941 AAA domain; Region: AAA_18; pfam13238 1230340007942 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1230340007943 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1230340007944 active site 1230340007945 substrate binding site [chemical binding]; other site 1230340007946 metal binding site [ion binding]; metal-binding site 1230340007947 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1230340007948 active site 1230340007949 catalytic residues [active] 1230340007950 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1230340007951 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1230340007952 NAD binding site [chemical binding]; other site 1230340007953 homodimer interface [polypeptide binding]; other site 1230340007954 active site 1230340007955 substrate binding site [chemical binding]; other site 1230340007956 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1230340007957 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1230340007958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1230340007959 TPR repeat; Region: TPR_11; pfam13414 1230340007960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1230340007961 binding surface 1230340007962 TPR motif; other site 1230340007963 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1230340007964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1230340007965 binding surface 1230340007966 TPR motif; other site 1230340007967 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1230340007968 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1230340007969 putative trimer interface [polypeptide binding]; other site 1230340007970 putative CoA binding site [chemical binding]; other site 1230340007971 pyrophosphatase PpaX; Provisional; Region: PRK13288 1230340007972 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340007973 motif II; other site 1230340007974 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1230340007975 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1230340007976 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1230340007977 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1230340007978 Hpr binding site; other site 1230340007979 active site 1230340007980 homohexamer subunit interaction site [polypeptide binding]; other site 1230340007981 Predicted membrane protein [Function unknown]; Region: COG1950 1230340007982 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1230340007983 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1230340007984 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1230340007985 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1230340007986 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1230340007987 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1230340007988 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1230340007989 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1230340007990 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1230340007991 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1230340007992 excinuclease ABC subunit B; Provisional; Region: PRK05298 1230340007993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1230340007994 ATP binding site [chemical binding]; other site 1230340007995 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1230340007996 nucleotide binding region [chemical binding]; other site 1230340007997 ATP-binding site [chemical binding]; other site 1230340007998 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1230340007999 UvrB/uvrC motif; Region: UVR; pfam02151 1230340008000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 1230340008001 HD containing hydrolase-like enzyme; Region: HD_2; pfam12917 1230340008002 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1230340008003 dimerization interface [polypeptide binding]; other site 1230340008004 putative DNA binding site [nucleotide binding]; other site 1230340008005 putative Zn2+ binding site [ion binding]; other site 1230340008006 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1230340008007 PhoU domain; Region: PhoU; pfam01895 1230340008008 PhoU domain; Region: PhoU; pfam01895 1230340008009 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1230340008010 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1230340008011 Walker A/P-loop; other site 1230340008012 ATP binding site [chemical binding]; other site 1230340008013 Q-loop/lid; other site 1230340008014 ABC transporter signature motif; other site 1230340008015 Walker B; other site 1230340008016 D-loop; other site 1230340008017 H-loop/switch region; other site 1230340008018 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1230340008019 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1230340008020 Walker A/P-loop; other site 1230340008021 ATP binding site [chemical binding]; other site 1230340008022 Q-loop/lid; other site 1230340008023 ABC transporter signature motif; other site 1230340008024 Walker B; other site 1230340008025 D-loop; other site 1230340008026 H-loop/switch region; other site 1230340008027 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1230340008028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340008029 dimer interface [polypeptide binding]; other site 1230340008030 conserved gate region; other site 1230340008031 putative PBP binding loops; other site 1230340008032 ABC-ATPase subunit interface; other site 1230340008033 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1230340008034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340008035 dimer interface [polypeptide binding]; other site 1230340008036 conserved gate region; other site 1230340008037 putative PBP binding loops; other site 1230340008038 ABC-ATPase subunit interface; other site 1230340008039 PBP superfamily domain; Region: PBP_like_2; cl17296 1230340008040 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1230340008041 HAMP domain; Region: HAMP; pfam00672 1230340008042 dimerization interface [polypeptide binding]; other site 1230340008043 PAS domain; Region: PAS; smart00091 1230340008044 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1230340008045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1230340008046 dimer interface [polypeptide binding]; other site 1230340008047 phosphorylation site [posttranslational modification] 1230340008048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340008049 ATP binding site [chemical binding]; other site 1230340008050 Mg2+ binding site [ion binding]; other site 1230340008051 G-X-G motif; other site 1230340008052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1230340008053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340008054 active site 1230340008055 phosphorylation site [posttranslational modification] 1230340008056 intermolecular recognition site; other site 1230340008057 dimerization interface [polypeptide binding]; other site 1230340008058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1230340008059 DNA binding site [nucleotide binding] 1230340008060 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1230340008061 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1230340008062 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1230340008063 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1230340008064 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1230340008065 putative active site [active] 1230340008066 catalytic site [active] 1230340008067 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1230340008068 putative active site [active] 1230340008069 catalytic site [active] 1230340008070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1230340008071 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1230340008072 Peptidase family M23; Region: Peptidase_M23; pfam01551 1230340008073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1230340008074 NlpC/P60 family; Region: NLPC_P60; pfam00877 1230340008075 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1230340008076 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1230340008077 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1230340008078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340008079 Walker A/P-loop; other site 1230340008080 ATP binding site [chemical binding]; other site 1230340008081 Q-loop/lid; other site 1230340008082 ABC transporter signature motif; other site 1230340008083 Walker B; other site 1230340008084 D-loop; other site 1230340008085 H-loop/switch region; other site 1230340008086 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1230340008087 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1230340008088 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1230340008089 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1230340008090 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1230340008091 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1230340008092 RF-1 domain; Region: RF-1; pfam00472 1230340008093 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1230340008094 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1230340008095 nucleotide binding region [chemical binding]; other site 1230340008096 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1230340008097 ATP-binding site [chemical binding]; other site 1230340008098 SEC-C motif; Region: SEC-C; pfam02810 1230340008099 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1230340008100 30S subunit binding site; other site 1230340008101 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1230340008102 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1230340008103 active site 1230340008104 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1230340008105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1230340008106 ATP binding site [chemical binding]; other site 1230340008107 putative Mg++ binding site [ion binding]; other site 1230340008108 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1230340008109 nucleotide binding region [chemical binding]; other site 1230340008110 ATP-binding site [chemical binding]; other site 1230340008111 EDD domain protein, DegV family; Region: DegV; TIGR00762 1230340008112 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1230340008113 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1230340008114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340008115 active site 1230340008116 phosphorylation site [posttranslational modification] 1230340008117 intermolecular recognition site; other site 1230340008118 dimerization interface [polypeptide binding]; other site 1230340008119 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1230340008120 DNA binding residues [nucleotide binding] 1230340008121 dimerization interface [polypeptide binding]; other site 1230340008122 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1230340008123 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1230340008124 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1230340008125 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1230340008126 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1230340008127 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1230340008128 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1230340008129 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1230340008130 Mg++ binding site [ion binding]; other site 1230340008131 putative catalytic motif [active] 1230340008132 substrate binding site [chemical binding]; other site 1230340008133 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1230340008134 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1230340008135 active site 1230340008136 octamer interface [polypeptide binding]; other site 1230340008137 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1230340008138 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1230340008139 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1230340008140 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1230340008141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1230340008142 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1230340008143 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1230340008144 dimer interface [polypeptide binding]; other site 1230340008145 ssDNA binding site [nucleotide binding]; other site 1230340008146 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1230340008147 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1230340008148 MreB and similar proteins; Region: MreB_like; cd10225 1230340008149 nucleotide binding site [chemical binding]; other site 1230340008150 Mg binding site [ion binding]; other site 1230340008151 putative protofilament interaction site [polypeptide binding]; other site 1230340008152 RodZ interaction site [polypeptide binding]; other site 1230340008153 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1230340008154 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1230340008155 hinge; other site 1230340008156 active site 1230340008157 Predicted membrane protein [Function unknown]; Region: COG4836 1230340008158 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1230340008159 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1230340008160 gamma subunit interface [polypeptide binding]; other site 1230340008161 epsilon subunit interface [polypeptide binding]; other site 1230340008162 LBP interface [polypeptide binding]; other site 1230340008163 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1230340008164 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1230340008165 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1230340008166 alpha subunit interaction interface [polypeptide binding]; other site 1230340008167 Walker A motif; other site 1230340008168 ATP binding site [chemical binding]; other site 1230340008169 Walker B motif; other site 1230340008170 inhibitor binding site; inhibition site 1230340008171 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1230340008172 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1230340008173 core domain interface [polypeptide binding]; other site 1230340008174 delta subunit interface [polypeptide binding]; other site 1230340008175 epsilon subunit interface [polypeptide binding]; other site 1230340008176 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1230340008177 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1230340008178 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1230340008179 beta subunit interaction interface [polypeptide binding]; other site 1230340008180 Walker A motif; other site 1230340008181 ATP binding site [chemical binding]; other site 1230340008182 Walker B motif; other site 1230340008183 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1230340008184 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1230340008185 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1230340008186 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1230340008187 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1230340008188 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1230340008189 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1230340008190 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1230340008191 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1230340008192 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1230340008193 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1230340008194 active site 1230340008195 homodimer interface [polypeptide binding]; other site 1230340008196 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1230340008197 active site 1230340008198 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1230340008199 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1230340008200 dimer interface [polypeptide binding]; other site 1230340008201 active site 1230340008202 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1230340008203 folate binding site [chemical binding]; other site 1230340008204 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1230340008205 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1230340008206 active site 1230340008207 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1230340008208 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1230340008209 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1230340008210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340008211 S-adenosylmethionine binding site [chemical binding]; other site 1230340008212 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1230340008213 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1230340008214 RF-1 domain; Region: RF-1; pfam00472 1230340008215 thymidine kinase; Provisional; Region: PRK04296 1230340008216 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1230340008217 ATP binding site [chemical binding]; other site 1230340008218 Walker A motif; other site 1230340008219 Walker B motif; other site 1230340008220 homoserine kinase; Provisional; Region: PRK01212 1230340008221 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1230340008222 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1230340008223 threonine synthase; Reviewed; Region: PRK06721 1230340008224 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1230340008225 homodimer interface [polypeptide binding]; other site 1230340008226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340008227 catalytic residue [active] 1230340008228 homoserine dehydrogenase; Provisional; Region: PRK06349 1230340008229 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1230340008230 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1230340008231 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1230340008232 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1230340008233 Predicted membrane protein [Function unknown]; Region: COG2246 1230340008234 GtrA-like protein; Region: GtrA; pfam04138 1230340008235 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1230340008236 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1230340008237 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1230340008238 RNA binding site [nucleotide binding]; other site 1230340008239 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1230340008240 multimer interface [polypeptide binding]; other site 1230340008241 Walker A motif; other site 1230340008242 ATP binding site [chemical binding]; other site 1230340008243 Walker B motif; other site 1230340008244 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1230340008245 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1230340008246 hinge; other site 1230340008247 active site 1230340008248 Predicted integral membrane protein [Function unknown]; Region: COG0392 1230340008249 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1230340008250 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1230340008251 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1230340008252 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1230340008253 putative ADP-binding pocket [chemical binding]; other site 1230340008254 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1230340008255 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1230340008256 intersubunit interface [polypeptide binding]; other site 1230340008257 active site 1230340008258 zinc binding site [ion binding]; other site 1230340008259 Na+ binding site [ion binding]; other site 1230340008260 putative lipid kinase; Reviewed; Region: PRK13055 1230340008261 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1230340008262 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1230340008263 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1230340008264 substrate binding site [chemical binding]; other site 1230340008265 SH3-like domain; Region: SH3_8; pfam13457 1230340008266 SH3-like domain; Region: SH3_8; pfam13457 1230340008267 SH3-like domain; Region: SH3_8; pfam13457 1230340008268 CTP synthetase; Validated; Region: pyrG; PRK05380 1230340008269 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1230340008270 Catalytic site [active] 1230340008271 active site 1230340008272 UTP binding site [chemical binding]; other site 1230340008273 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1230340008274 active site 1230340008275 putative oxyanion hole; other site 1230340008276 catalytic triad [active] 1230340008277 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1230340008278 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1230340008279 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1230340008280 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1230340008281 active site 1230340008282 HIGH motif; other site 1230340008283 KMSK motif region; other site 1230340008284 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1230340008285 tRNA binding surface [nucleotide binding]; other site 1230340008286 anticodon binding site; other site 1230340008287 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1230340008288 Peptidase family M50; Region: Peptidase_M50; pfam02163 1230340008289 active site 1230340008290 putative substrate binding region [chemical binding]; other site 1230340008291 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1230340008292 active site 1 [active] 1230340008293 dimer interface [polypeptide binding]; other site 1230340008294 hexamer interface [polypeptide binding]; other site 1230340008295 active site 2 [active] 1230340008296 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1230340008297 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1230340008298 Zn2+ binding site [ion binding]; other site 1230340008299 Mg2+ binding site [ion binding]; other site 1230340008300 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1230340008301 conserved hypothetical protein TIGR01655; Region: yxeA_fam 1230340008302 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1230340008303 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1230340008304 peptide binding site [polypeptide binding]; other site 1230340008305 Predicted integral membrane protein [Function unknown]; Region: COG5658 1230340008306 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1230340008307 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1230340008308 catalytic triad [active] 1230340008309 metal binding site [ion binding]; metal-binding site 1230340008310 conserved cis-peptide bond; other site 1230340008311 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1230340008312 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1230340008313 folate binding site [chemical binding]; other site 1230340008314 NADP+ binding site [chemical binding]; other site 1230340008315 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1230340008316 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1230340008317 putative NAD(P) binding site [chemical binding]; other site 1230340008318 dimer interface [polypeptide binding]; other site 1230340008319 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1230340008320 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1230340008321 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1230340008322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340008323 active site 1230340008324 motif I; other site 1230340008325 motif II; other site 1230340008326 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1230340008327 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1230340008328 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1230340008329 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1230340008330 FtsX-like permease family; Region: FtsX; pfam02687 1230340008331 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1230340008332 dimerization interface [polypeptide binding]; other site 1230340008333 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1230340008334 dimer interface [polypeptide binding]; other site 1230340008335 phosphorylation site [posttranslational modification] 1230340008336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340008337 ATP binding site [chemical binding]; other site 1230340008338 Mg2+ binding site [ion binding]; other site 1230340008339 G-X-G motif; other site 1230340008340 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1230340008341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340008342 active site 1230340008343 phosphorylation site [posttranslational modification] 1230340008344 intermolecular recognition site; other site 1230340008345 dimerization interface [polypeptide binding]; other site 1230340008346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1230340008347 DNA binding site [nucleotide binding] 1230340008348 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1230340008349 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1230340008350 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1230340008351 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1230340008352 catalytic loop [active] 1230340008353 iron binding site [ion binding]; other site 1230340008354 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1230340008355 4Fe-4S binding domain; Region: Fer4; pfam00037 1230340008356 4Fe-4S binding domain; Region: Fer4; pfam00037 1230340008357 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1230340008358 [4Fe-4S] binding site [ion binding]; other site 1230340008359 molybdopterin cofactor binding site; other site 1230340008360 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1230340008361 molybdopterin cofactor binding site; other site 1230340008362 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1230340008363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340008364 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1230340008365 putative substrate translocation pore; other site 1230340008366 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1230340008367 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1230340008368 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1230340008369 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1230340008370 Walker A motif; other site 1230340008371 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1230340008372 SH3-like domain; Region: SH3_8; pfam13457 1230340008373 SH3-like domain; Region: SH3_8; pfam13457 1230340008374 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1230340008375 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1230340008376 active site 1230340008377 catalytic tetrad [active] 1230340008378 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1230340008379 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1230340008380 DNA binding residues [nucleotide binding] 1230340008381 putative dimer interface [polypeptide binding]; other site 1230340008382 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1230340008383 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1230340008384 23S rRNA interface [nucleotide binding]; other site 1230340008385 L3 interface [polypeptide binding]; other site 1230340008386 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1230340008387 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1230340008388 dimerization interface 3.5A [polypeptide binding]; other site 1230340008389 active site 1230340008390 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1230340008391 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1230340008392 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1230340008393 Walker A/P-loop; other site 1230340008394 ATP binding site [chemical binding]; other site 1230340008395 Q-loop/lid; other site 1230340008396 ABC transporter signature motif; other site 1230340008397 Walker B; other site 1230340008398 D-loop; other site 1230340008399 H-loop/switch region; other site 1230340008400 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1230340008401 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1230340008402 Walker A/P-loop; other site 1230340008403 ATP binding site [chemical binding]; other site 1230340008404 Q-loop/lid; other site 1230340008405 ABC transporter signature motif; other site 1230340008406 Walker B; other site 1230340008407 D-loop; other site 1230340008408 H-loop/switch region; other site 1230340008409 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1230340008410 MgtC family; Region: MgtC; pfam02308 1230340008411 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1230340008412 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1230340008413 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1230340008414 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1230340008415 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1230340008416 alphaNTD - beta interaction site [polypeptide binding]; other site 1230340008417 alphaNTD homodimer interface [polypeptide binding]; other site 1230340008418 alphaNTD - beta' interaction site [polypeptide binding]; other site 1230340008419 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1230340008420 30S ribosomal protein S11; Validated; Region: PRK05309 1230340008421 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1230340008422 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1230340008423 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1230340008424 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1230340008425 rRNA binding site [nucleotide binding]; other site 1230340008426 predicted 30S ribosome binding site; other site 1230340008427 adenylate kinase; Reviewed; Region: adk; PRK00279 1230340008428 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1230340008429 AMP-binding site [chemical binding]; other site 1230340008430 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1230340008431 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1230340008432 SecY translocase; Region: SecY; pfam00344 1230340008433 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1230340008434 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1230340008435 23S rRNA binding site [nucleotide binding]; other site 1230340008436 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1230340008437 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1230340008438 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1230340008439 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1230340008440 5S rRNA interface [nucleotide binding]; other site 1230340008441 L27 interface [polypeptide binding]; other site 1230340008442 23S rRNA interface [nucleotide binding]; other site 1230340008443 L5 interface [polypeptide binding]; other site 1230340008444 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1230340008445 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1230340008446 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1230340008447 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1230340008448 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1230340008449 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1230340008450 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1230340008451 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1230340008452 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1230340008453 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1230340008454 RNA binding site [nucleotide binding]; other site 1230340008455 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1230340008456 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1230340008457 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1230340008458 23S rRNA interface [nucleotide binding]; other site 1230340008459 putative translocon interaction site; other site 1230340008460 signal recognition particle (SRP54) interaction site; other site 1230340008461 L23 interface [polypeptide binding]; other site 1230340008462 trigger factor interaction site; other site 1230340008463 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1230340008464 23S rRNA interface [nucleotide binding]; other site 1230340008465 5S rRNA interface [nucleotide binding]; other site 1230340008466 putative antibiotic binding site [chemical binding]; other site 1230340008467 L25 interface [polypeptide binding]; other site 1230340008468 L27 interface [polypeptide binding]; other site 1230340008469 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1230340008470 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1230340008471 G-X-X-G motif; other site 1230340008472 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1230340008473 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1230340008474 putative translocon binding site; other site 1230340008475 protein-rRNA interface [nucleotide binding]; other site 1230340008476 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1230340008477 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1230340008478 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1230340008479 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1230340008480 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1230340008481 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1230340008482 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1230340008483 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1230340008484 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1230340008485 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 1230340008486 UbiA prenyltransferase family; Region: UbiA; pfam01040 1230340008487 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1230340008488 ApbE family; Region: ApbE; pfam02424 1230340008489 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 1230340008490 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 1230340008491 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 1230340008492 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1230340008493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1230340008494 Predicted membrane protein [Function unknown]; Region: COG2259 1230340008495 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 1230340008496 trimer interface [polypeptide binding]; other site 1230340008497 Predicted membrane protein [Function unknown]; Region: COG4769 1230340008498 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1230340008499 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1230340008500 substrate binding pocket [chemical binding]; other site 1230340008501 chain length determination region; other site 1230340008502 substrate-Mg2+ binding site; other site 1230340008503 catalytic residues [active] 1230340008504 aspartate-rich region 1; other site 1230340008505 active site lid residues [active] 1230340008506 aspartate-rich region 2; other site 1230340008507 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1230340008508 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1230340008509 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1230340008510 active site 1230340008511 metal binding site [ion binding]; metal-binding site 1230340008512 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1230340008513 hypothetical protein; Provisional; Region: PRK02947 1230340008514 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1230340008515 putative active site [active] 1230340008516 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 1230340008517 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 1230340008518 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1230340008519 active site 1230340008520 substrate binding pocket [chemical binding]; other site 1230340008521 homodimer interaction site [polypeptide binding]; other site 1230340008522 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1230340008523 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1230340008524 active site 1230340008525 P-loop; other site 1230340008526 phosphorylation site [posttranslational modification] 1230340008527 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340008528 active site 1230340008529 phosphorylation site [posttranslational modification] 1230340008530 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1230340008531 Mga helix-turn-helix domain; Region: Mga; pfam05043 1230340008532 PRD domain; Region: PRD; pfam00874 1230340008533 PRD domain; Region: PRD; pfam00874 1230340008534 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1230340008535 active site 1230340008536 P-loop; other site 1230340008537 phosphorylation site [posttranslational modification] 1230340008538 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340008539 active site 1230340008540 phosphorylation site [posttranslational modification] 1230340008541 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1230340008542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340008543 Walker A/P-loop; other site 1230340008544 ATP binding site [chemical binding]; other site 1230340008545 Q-loop/lid; other site 1230340008546 ABC transporter signature motif; other site 1230340008547 Walker B; other site 1230340008548 D-loop; other site 1230340008549 H-loop/switch region; other site 1230340008550 elongation factor Tu; Reviewed; Region: PRK00049 1230340008551 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1230340008552 G1 box; other site 1230340008553 GEF interaction site [polypeptide binding]; other site 1230340008554 GTP/Mg2+ binding site [chemical binding]; other site 1230340008555 Switch I region; other site 1230340008556 G2 box; other site 1230340008557 G3 box; other site 1230340008558 Switch II region; other site 1230340008559 G4 box; other site 1230340008560 G5 box; other site 1230340008561 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1230340008562 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1230340008563 Antibiotic Binding Site [chemical binding]; other site 1230340008564 elongation factor G; Reviewed; Region: PRK00007 1230340008565 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1230340008566 G1 box; other site 1230340008567 putative GEF interaction site [polypeptide binding]; other site 1230340008568 GTP/Mg2+ binding site [chemical binding]; other site 1230340008569 Switch I region; other site 1230340008570 G2 box; other site 1230340008571 G3 box; other site 1230340008572 Switch II region; other site 1230340008573 G4 box; other site 1230340008574 G5 box; other site 1230340008575 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1230340008576 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1230340008577 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1230340008578 30S ribosomal protein S7; Validated; Region: PRK05302 1230340008579 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1230340008580 S17 interaction site [polypeptide binding]; other site 1230340008581 S8 interaction site; other site 1230340008582 16S rRNA interaction site [nucleotide binding]; other site 1230340008583 streptomycin interaction site [chemical binding]; other site 1230340008584 23S rRNA interaction site [nucleotide binding]; other site 1230340008585 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1230340008586 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1230340008587 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1230340008588 Zn2+ binding site [ion binding]; other site 1230340008589 Mg2+ binding site [ion binding]; other site 1230340008590 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1230340008591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340008592 Coenzyme A binding pocket [chemical binding]; other site 1230340008593 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1230340008594 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340008595 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340008596 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1230340008597 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1230340008598 substrate binding site [chemical binding]; other site 1230340008599 hexamer interface [polypeptide binding]; other site 1230340008600 metal binding site [ion binding]; metal-binding site 1230340008601 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1230340008602 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1230340008603 TPP-binding site [chemical binding]; other site 1230340008604 dimer interface [polypeptide binding]; other site 1230340008605 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1230340008606 PYR/PP interface [polypeptide binding]; other site 1230340008607 dimer interface [polypeptide binding]; other site 1230340008608 TPP binding site [chemical binding]; other site 1230340008609 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1230340008610 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1230340008611 substrate binding site [chemical binding]; other site 1230340008612 hexamer interface [polypeptide binding]; other site 1230340008613 metal binding site [ion binding]; metal-binding site 1230340008614 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1230340008615 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1230340008616 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1230340008617 putative NAD(P) binding site [chemical binding]; other site 1230340008618 catalytic Zn binding site [ion binding]; other site 1230340008619 structural Zn binding site [ion binding]; other site 1230340008620 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1230340008621 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1230340008622 putative NAD(P) binding site [chemical binding]; other site 1230340008623 catalytic Zn binding site [ion binding]; other site 1230340008624 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1230340008625 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1230340008626 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1230340008627 active site 1230340008628 P-loop; other site 1230340008629 phosphorylation site [posttranslational modification] 1230340008630 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340008631 active site 1230340008632 phosphorylation site [posttranslational modification] 1230340008633 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1230340008634 PRD domain; Region: PRD; pfam00874 1230340008635 PRD domain; Region: PRD; pfam00874 1230340008636 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1230340008637 active site 1230340008638 P-loop; other site 1230340008639 phosphorylation site [posttranslational modification] 1230340008640 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 1230340008641 active site 1230340008642 phosphorylation site [posttranslational modification] 1230340008643 Predicted membrane protein [Function unknown]; Region: COG4905 1230340008644 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1230340008645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1230340008646 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1230340008647 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1230340008648 active site 1230340008649 Helix-turn-helix domain; Region: HTH_18; pfam12833 1230340008650 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1230340008651 Ligand Binding Site [chemical binding]; other site 1230340008652 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1230340008653 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1230340008654 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1230340008655 active site 1230340008656 DNA binding site [nucleotide binding] 1230340008657 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1230340008658 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1230340008659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1230340008660 active site 1230340008661 phosphorylation site [posttranslational modification] 1230340008662 intermolecular recognition site; other site 1230340008663 dimerization interface [polypeptide binding]; other site 1230340008664 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1230340008665 DNA binding site [nucleotide binding] 1230340008666 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1230340008667 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1230340008668 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1230340008669 Ligand Binding Site [chemical binding]; other site 1230340008670 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1230340008671 GAF domain; Region: GAF_3; pfam13492 1230340008672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1230340008673 dimer interface [polypeptide binding]; other site 1230340008674 phosphorylation site [posttranslational modification] 1230340008675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1230340008676 ATP binding site [chemical binding]; other site 1230340008677 Mg2+ binding site [ion binding]; other site 1230340008678 G-X-G motif; other site 1230340008679 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 1230340008680 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1230340008681 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1230340008682 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1230340008683 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1230340008684 active site 1230340008685 P-loop; other site 1230340008686 phosphorylation site [posttranslational modification] 1230340008687 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1230340008688 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1230340008689 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1230340008690 methionine cluster; other site 1230340008691 active site 1230340008692 phosphorylation site [posttranslational modification] 1230340008693 metal binding site [ion binding]; metal-binding site 1230340008694 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1230340008695 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1230340008696 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 1230340008697 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1230340008698 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1230340008699 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1230340008700 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1230340008701 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1230340008702 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1230340008703 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1230340008704 autolysin; Reviewed; Region: PRK06347 1230340008705 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1230340008706 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1230340008707 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1230340008708 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1230340008709 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1230340008710 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1230340008711 thymidylate kinase; Validated; Region: tmk; PRK00698 1230340008712 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1230340008713 TMP-binding site; other site 1230340008714 ATP-binding site [chemical binding]; other site 1230340008715 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1230340008716 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1230340008717 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1230340008718 catalytic residue [active] 1230340008719 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1230340008720 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1230340008721 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1230340008722 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1230340008723 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1230340008724 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1230340008725 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1230340008726 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1230340008727 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1230340008728 putative active site [active] 1230340008729 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1230340008730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340008731 active site 1230340008732 motif I; other site 1230340008733 motif II; other site 1230340008734 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1230340008735 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1230340008736 nudix motif; other site 1230340008737 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1230340008738 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1230340008739 active site 1230340008740 catalytic tetrad [active] 1230340008741 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1230340008742 recombination protein RecR; Reviewed; Region: recR; PRK00076 1230340008743 RecR protein; Region: RecR; pfam02132 1230340008744 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1230340008745 putative active site [active] 1230340008746 putative metal-binding site [ion binding]; other site 1230340008747 tetramer interface [polypeptide binding]; other site 1230340008748 hypothetical protein; Validated; Region: PRK00153 1230340008749 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1230340008750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1230340008751 Walker A motif; other site 1230340008752 ATP binding site [chemical binding]; other site 1230340008753 Walker B motif; other site 1230340008754 arginine finger; other site 1230340008755 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1230340008756 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 1230340008757 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 1230340008758 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1230340008759 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1230340008760 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1230340008761 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1230340008762 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1230340008763 N- and C-terminal domain interface [polypeptide binding]; other site 1230340008764 active site 1230340008765 catalytic site [active] 1230340008766 metal binding site [ion binding]; metal-binding site 1230340008767 carbohydrate binding site [chemical binding]; other site 1230340008768 ATP binding site [chemical binding]; other site 1230340008769 SH3-like domain; Region: SH3_8; pfam13457 1230340008770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1230340008771 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1230340008772 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1230340008773 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1230340008774 Walker A/P-loop; other site 1230340008775 ATP binding site [chemical binding]; other site 1230340008776 Q-loop/lid; other site 1230340008777 ABC transporter signature motif; other site 1230340008778 Walker B; other site 1230340008779 D-loop; other site 1230340008780 H-loop/switch region; other site 1230340008781 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1230340008782 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1230340008783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340008784 Walker A/P-loop; other site 1230340008785 ATP binding site [chemical binding]; other site 1230340008786 Q-loop/lid; other site 1230340008787 ABC transporter signature motif; other site 1230340008788 Walker B; other site 1230340008789 D-loop; other site 1230340008790 H-loop/switch region; other site 1230340008791 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1230340008792 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1230340008793 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1230340008794 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1230340008795 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1230340008796 nucleoside/Zn binding site; other site 1230340008797 dimer interface [polypeptide binding]; other site 1230340008798 catalytic motif [active] 1230340008799 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1230340008800 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1230340008801 active site 1230340008802 acyl-activating enzyme (AAE) consensus motif; other site 1230340008803 putative CoA binding site [chemical binding]; other site 1230340008804 AMP binding site [chemical binding]; other site 1230340008805 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1230340008806 substrate binding site [chemical binding]; other site 1230340008807 activation loop (A-loop); other site 1230340008808 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1230340008809 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1230340008810 active site 1230340008811 trimer interface [polypeptide binding]; other site 1230340008812 allosteric site; other site 1230340008813 active site lid [active] 1230340008814 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1230340008815 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1230340008816 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1230340008817 DNA binding residues [nucleotide binding] 1230340008818 drug binding residues [chemical binding]; other site 1230340008819 dimer interface [polypeptide binding]; other site 1230340008820 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1230340008821 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1230340008822 Coenzyme A binding pocket [chemical binding]; other site 1230340008823 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1230340008824 dimer interface [polypeptide binding]; other site 1230340008825 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1230340008826 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1230340008827 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1230340008828 MarR family; Region: MarR; pfam01047 1230340008829 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1230340008830 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1230340008831 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1230340008832 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1230340008833 DNA binding residues [nucleotide binding] 1230340008834 putative dimer interface [polypeptide binding]; other site 1230340008835 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1230340008836 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1230340008837 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340008838 active site 1230340008839 motif I; other site 1230340008840 motif II; other site 1230340008841 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1230340008842 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1230340008843 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1230340008844 putative active site [active] 1230340008845 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1230340008846 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340008847 active site 1230340008848 phosphorylation site [posttranslational modification] 1230340008849 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1230340008850 active site 1230340008851 P-loop; other site 1230340008852 phosphorylation site [posttranslational modification] 1230340008853 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1230340008854 alpha-mannosidase; Provisional; Region: PRK09819 1230340008855 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 1230340008856 active site 1230340008857 metal binding site [ion binding]; metal-binding site 1230340008858 catalytic site [active] 1230340008859 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 1230340008860 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1230340008861 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1230340008862 active site 1230340008863 homodimer interface [polypeptide binding]; other site 1230340008864 catalytic site [active] 1230340008865 glycerate kinase; Region: TIGR00045 1230340008866 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1230340008867 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1230340008868 DNA binding site [nucleotide binding] 1230340008869 domain linker motif; other site 1230340008870 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1230340008871 putative dimerization interface [polypeptide binding]; other site 1230340008872 putative ligand binding site [chemical binding]; other site 1230340008873 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1230340008874 Domain of unknown function DUF21; Region: DUF21; pfam01595 1230340008875 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1230340008876 Transporter associated domain; Region: CorC_HlyC; pfam03471 1230340008877 NAD-dependent deacetylase; Provisional; Region: PRK00481 1230340008878 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1230340008879 NAD+ binding site [chemical binding]; other site 1230340008880 substrate binding site [chemical binding]; other site 1230340008881 putative Zn binding site [ion binding]; other site 1230340008882 Pathogenicity locus; Region: Cdd1; pfam11731 1230340008883 drug efflux system protein MdtG; Provisional; Region: PRK09874 1230340008884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340008885 putative substrate translocation pore; other site 1230340008886 Src Homology 3 domain superfamily; Region: SH3; cl17036 1230340008887 Variant SH3 domain; Region: SH3_2; pfam07653 1230340008888 peptide ligand binding site [polypeptide binding]; other site 1230340008889 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1230340008890 active site 1230340008891 intersubunit interactions; other site 1230340008892 catalytic residue [active] 1230340008893 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1230340008894 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1230340008895 ligand binding site [chemical binding]; other site 1230340008896 flexible hinge region; other site 1230340008897 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1230340008898 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1230340008899 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1230340008900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340008901 Walker A/P-loop; other site 1230340008902 ATP binding site [chemical binding]; other site 1230340008903 Q-loop/lid; other site 1230340008904 ABC transporter signature motif; other site 1230340008905 Walker B; other site 1230340008906 D-loop; other site 1230340008907 H-loop/switch region; other site 1230340008908 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1230340008909 seryl-tRNA synthetase; Provisional; Region: PRK05431 1230340008910 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1230340008911 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1230340008912 dimer interface [polypeptide binding]; other site 1230340008913 active site 1230340008914 motif 1; other site 1230340008915 motif 2; other site 1230340008916 motif 3; other site 1230340008917 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1230340008918 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1230340008919 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1230340008920 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1230340008921 glutamine binding [chemical binding]; other site 1230340008922 catalytic triad [active] 1230340008923 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1230340008924 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1230340008925 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1230340008926 substrate-cofactor binding pocket; other site 1230340008927 homodimer interface [polypeptide binding]; other site 1230340008928 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1230340008929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1230340008930 catalytic residue [active] 1230340008931 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1230340008932 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1230340008933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340008934 Walker A/P-loop; other site 1230340008935 ATP binding site [chemical binding]; other site 1230340008936 Q-loop/lid; other site 1230340008937 ABC transporter signature motif; other site 1230340008938 Walker B; other site 1230340008939 D-loop; other site 1230340008940 H-loop/switch region; other site 1230340008941 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1230340008942 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1230340008943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1230340008944 Walker A/P-loop; other site 1230340008945 ATP binding site [chemical binding]; other site 1230340008946 Q-loop/lid; other site 1230340008947 ABC transporter signature motif; other site 1230340008948 Walker B; other site 1230340008949 D-loop; other site 1230340008950 H-loop/switch region; other site 1230340008951 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1230340008952 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1230340008953 Ligand binding site; other site 1230340008954 Putative Catalytic site; other site 1230340008955 DXD motif; other site 1230340008956 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1230340008957 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1230340008958 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1230340008959 Predicted acyl esterases [General function prediction only]; Region: COG2936 1230340008960 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1230340008961 DNA topoisomerase III; Provisional; Region: PRK07726 1230340008962 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1230340008963 active site 1230340008964 putative interdomain interaction site [polypeptide binding]; other site 1230340008965 putative metal-binding site [ion binding]; other site 1230340008966 putative nucleotide binding site [chemical binding]; other site 1230340008967 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1230340008968 domain I; other site 1230340008969 DNA binding groove [nucleotide binding] 1230340008970 phosphate binding site [ion binding]; other site 1230340008971 domain II; other site 1230340008972 domain III; other site 1230340008973 nucleotide binding site [chemical binding]; other site 1230340008974 catalytic site [active] 1230340008975 domain IV; other site 1230340008976 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1230340008977 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1230340008978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1230340008979 ATP binding site [chemical binding]; other site 1230340008980 putative Mg++ binding site [ion binding]; other site 1230340008981 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1230340008982 nucleotide binding region [chemical binding]; other site 1230340008983 ATP-binding site [chemical binding]; other site 1230340008984 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1230340008985 HRDC domain; Region: HRDC; pfam00570 1230340008986 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 1230340008987 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1230340008988 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1230340008989 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1230340008990 active site 1230340008991 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1230340008992 putative ADP-ribose binding site [chemical binding]; other site 1230340008993 putative active site [active] 1230340008994 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1230340008995 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1230340008996 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1230340008997 ABC transporter; Region: ABC_tran_2; pfam12848 1230340008998 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1230340008999 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1230340009000 beta-galactosidase; Region: BGL; TIGR03356 1230340009001 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1230340009002 active site 1230340009003 P-loop; other site 1230340009004 phosphorylation site [posttranslational modification] 1230340009005 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1230340009006 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1230340009007 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1230340009008 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1230340009009 nucleotide binding site [chemical binding]; other site 1230340009010 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1230340009011 methionine cluster; other site 1230340009012 active site 1230340009013 phosphorylation site [posttranslational modification] 1230340009014 metal binding site [ion binding]; metal-binding site 1230340009015 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1230340009016 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1230340009017 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1230340009018 putative active site [active] 1230340009019 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 1230340009020 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 1230340009021 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1230340009022 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1230340009023 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1230340009024 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1230340009025 Walker A/P-loop; other site 1230340009026 ATP binding site [chemical binding]; other site 1230340009027 Q-loop/lid; other site 1230340009028 ABC transporter signature motif; other site 1230340009029 Walker B; other site 1230340009030 D-loop; other site 1230340009031 H-loop/switch region; other site 1230340009032 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1230340009033 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 1230340009034 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1230340009035 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1230340009036 beta-galactosidase; Region: BGL; TIGR03356 1230340009037 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1230340009038 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1230340009039 active site turn [active] 1230340009040 phosphorylation site [posttranslational modification] 1230340009041 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1230340009042 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1230340009043 HPr interaction site; other site 1230340009044 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1230340009045 active site 1230340009046 phosphorylation site [posttranslational modification] 1230340009047 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1230340009048 CAT RNA binding domain; Region: CAT_RBD; smart01061 1230340009049 PRD domain; Region: PRD; pfam00874 1230340009050 PRD domain; Region: PRD; pfam00874 1230340009051 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1230340009052 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1230340009053 Walker A/P-loop; other site 1230340009054 ATP binding site [chemical binding]; other site 1230340009055 Q-loop/lid; other site 1230340009056 ABC transporter signature motif; other site 1230340009057 Walker B; other site 1230340009058 D-loop; other site 1230340009059 H-loop/switch region; other site 1230340009060 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 1230340009061 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1230340009062 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 1230340009063 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1230340009064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340009065 putative substrate translocation pore; other site 1230340009066 GTP-binding protein YchF; Reviewed; Region: PRK09601 1230340009067 YchF GTPase; Region: YchF; cd01900 1230340009068 G1 box; other site 1230340009069 GTP/Mg2+ binding site [chemical binding]; other site 1230340009070 Switch I region; other site 1230340009071 G2 box; other site 1230340009072 Switch II region; other site 1230340009073 G3 box; other site 1230340009074 G4 box; other site 1230340009075 G5 box; other site 1230340009076 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1230340009077 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1230340009078 methionine cluster; other site 1230340009079 active site 1230340009080 phosphorylation site [posttranslational modification] 1230340009081 metal binding site [ion binding]; metal-binding site 1230340009082 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1230340009083 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1230340009084 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1230340009085 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1230340009086 active site 1230340009087 P-loop; other site 1230340009088 phosphorylation site [posttranslational modification] 1230340009089 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1230340009090 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1230340009091 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1230340009092 HTH domain; Region: HTH_11; pfam08279 1230340009093 Mga helix-turn-helix domain; Region: Mga; pfam05043 1230340009094 PRD domain; Region: PRD; pfam00874 1230340009095 PRD domain; Region: PRD; pfam00874 1230340009096 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1230340009097 active site 1230340009098 P-loop; other site 1230340009099 phosphorylation site [posttranslational modification] 1230340009100 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340009101 active site 1230340009102 phosphorylation site [posttranslational modification] 1230340009103 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1230340009104 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1230340009105 tetramer interface [polypeptide binding]; other site 1230340009106 heme binding pocket [chemical binding]; other site 1230340009107 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1230340009108 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1230340009109 ParB-like nuclease domain; Region: ParB; smart00470 1230340009110 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 1230340009111 salt bridge; other site 1230340009112 non-specific DNA binding site [nucleotide binding]; other site 1230340009113 sequence-specific DNA binding site [nucleotide binding]; other site 1230340009114 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1230340009115 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1230340009116 P-loop; other site 1230340009117 Magnesium ion binding site [ion binding]; other site 1230340009118 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1230340009119 Magnesium ion binding site [ion binding]; other site 1230340009120 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1230340009121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340009122 non-specific DNA binding site [nucleotide binding]; other site 1230340009123 salt bridge; other site 1230340009124 sequence-specific DNA binding site [nucleotide binding]; other site 1230340009125 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1230340009126 ParB-like nuclease domain; Region: ParBc; pfam02195 1230340009127 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1230340009128 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1230340009129 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1230340009130 putative active site [active] 1230340009131 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1230340009132 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1230340009133 nucleotide binding site [chemical binding]; other site 1230340009134 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1230340009135 active site 1230340009136 phosphorylation site [posttranslational modification] 1230340009137 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1230340009138 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340009139 motif II; other site 1230340009140 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1230340009141 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1230340009142 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1230340009143 active site 1230340009144 P-loop; other site 1230340009145 phosphorylation site [posttranslational modification] 1230340009146 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1230340009147 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1230340009148 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1230340009149 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1230340009150 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1230340009151 putative active site cavity [active] 1230340009152 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1230340009153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1230340009154 S-adenosylmethionine binding site [chemical binding]; other site 1230340009155 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 1230340009156 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 1230340009157 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 1230340009158 Abi-like protein; Region: Abi_2; pfam07751 1230340009159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1230340009160 non-specific DNA binding site [nucleotide binding]; other site 1230340009161 salt bridge; other site 1230340009162 sequence-specific DNA binding site [nucleotide binding]; other site 1230340009163 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1230340009164 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1230340009165 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1230340009166 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1230340009167 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1230340009168 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1230340009169 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1230340009170 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1230340009171 G1 box; other site 1230340009172 GTP/Mg2+ binding site [chemical binding]; other site 1230340009173 Switch I region; other site 1230340009174 G2 box; other site 1230340009175 Switch II region; other site 1230340009176 G3 box; other site 1230340009177 G4 box; other site 1230340009178 G5 box; other site 1230340009179 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1230340009180 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1230340009181 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1230340009182 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1230340009183 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1230340009184 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1230340009185 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1230340009186 NADP binding site [chemical binding]; other site 1230340009187 homodimer interface [polypeptide binding]; other site 1230340009188 active site 1230340009189 substrate binding site [chemical binding]; other site 1230340009190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340009191 D-galactonate transporter; Region: 2A0114; TIGR00893 1230340009192 putative substrate translocation pore; other site 1230340009193 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1230340009194 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1230340009195 metal binding site [ion binding]; metal-binding site 1230340009196 dimer interface [polypeptide binding]; other site 1230340009197 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1230340009198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1230340009199 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1230340009200 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1230340009201 metal binding site [ion binding]; metal-binding site 1230340009202 dimer interface [polypeptide binding]; other site 1230340009203 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1230340009204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1230340009205 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1230340009206 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 1230340009207 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1230340009208 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340009209 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340009210 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340009211 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340009212 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1230340009213 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1230340009214 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1230340009215 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1230340009216 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1230340009217 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1230340009218 putative ligand binding site [chemical binding]; other site 1230340009219 putative NAD binding site [chemical binding]; other site 1230340009220 putative catalytic site [active] 1230340009221 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1230340009222 L-serine binding site [chemical binding]; other site 1230340009223 ACT domain interface; other site 1230340009224 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1230340009225 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1230340009226 catalytic residue [active] 1230340009227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340009228 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1230340009229 putative substrate translocation pore; other site 1230340009230 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1230340009231 MarR family; Region: MarR_2; pfam12802 1230340009232 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1230340009233 dimer interface [polypeptide binding]; other site 1230340009234 FMN binding site [chemical binding]; other site 1230340009235 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1230340009236 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1230340009237 catalytic residues [active] 1230340009238 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1230340009239 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1230340009240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1230340009241 motif II; other site 1230340009242 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1230340009243 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1230340009244 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1230340009245 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1230340009246 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1230340009247 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1230340009248 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1230340009249 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1230340009250 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1230340009251 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1230340009252 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1230340009253 putative NAD(P) binding site [chemical binding]; other site 1230340009254 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1230340009255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340009256 dimer interface [polypeptide binding]; other site 1230340009257 conserved gate region; other site 1230340009258 putative PBP binding loops; other site 1230340009259 ABC-ATPase subunit interface; other site 1230340009260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1230340009261 dimer interface [polypeptide binding]; other site 1230340009262 conserved gate region; other site 1230340009263 putative PBP binding loops; other site 1230340009264 ABC-ATPase subunit interface; other site 1230340009265 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1230340009266 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1230340009267 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1230340009268 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1230340009269 active site 1230340009270 homodimer interface [polypeptide binding]; other site 1230340009271 catalytic site [active] 1230340009272 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1230340009273 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1230340009274 DNA binding site [nucleotide binding] 1230340009275 domain linker motif; other site 1230340009276 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1230340009277 putative dimerization interface [polypeptide binding]; other site 1230340009278 putative ligand binding site [chemical binding]; other site 1230340009279 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 1230340009280 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1230340009281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1230340009282 Coenzyme A binding pocket [chemical binding]; other site 1230340009283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340009284 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1230340009285 putative substrate translocation pore; other site 1230340009286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340009287 Domain of unknown function (DUF718); Region: DUF718; cl01281 1230340009288 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 1230340009289 intersubunit interface [polypeptide binding]; other site 1230340009290 active site 1230340009291 Zn2+ binding site [ion binding]; other site 1230340009292 L-rhamnose isomerase; Provisional; Region: PRK01076 1230340009293 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1230340009294 N- and C-terminal domain interface [polypeptide binding]; other site 1230340009295 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1230340009296 active site 1230340009297 putative catalytic site [active] 1230340009298 metal binding site [ion binding]; metal-binding site 1230340009299 ATP binding site [chemical binding]; other site 1230340009300 carbohydrate binding site [chemical binding]; other site 1230340009301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1230340009302 putative substrate translocation pore; other site 1230340009303 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1230340009304 Cupin domain; Region: Cupin_2; pfam07883 1230340009305 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1230340009306 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1230340009307 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1230340009308 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1230340009309 G-X-X-G motif; other site 1230340009310 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1230340009311 RxxxH motif; other site 1230340009312 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1230340009313 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1230340009314 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1230340009315 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399