-- dump date   	20140619_134038
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
863767000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
863767000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
863767000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767000004	Walker A motif; other site
863767000005	ATP binding site [chemical binding]; other site
863767000006	Walker B motif; other site
863767000007	arginine finger; other site
863767000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
863767000009	DnaA box-binding interface [nucleotide binding]; other site
863767000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
863767000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
863767000012	putative DNA binding surface [nucleotide binding]; other site
863767000013	dimer interface [polypeptide binding]; other site
863767000014	beta-clamp/clamp loader binding surface; other site
863767000015	beta-clamp/translesion DNA polymerase binding surface; other site
863767000016	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
863767000017	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
863767000018	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
863767000019	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
863767000020	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
863767000021	Walker A/P-loop; other site
863767000022	ATP binding site [chemical binding]; other site
863767000023	Q-loop/lid; other site
863767000024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767000025	ABC transporter signature motif; other site
863767000026	Walker B; other site
863767000027	D-loop; other site
863767000028	H-loop/switch region; other site
863767000029	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
863767000030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767000031	Mg2+ binding site [ion binding]; other site
863767000032	G-X-G motif; other site
863767000033	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
863767000034	anchoring element; other site
863767000035	dimer interface [polypeptide binding]; other site
863767000036	ATP binding site [chemical binding]; other site
863767000037	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
863767000038	active site
863767000039	putative metal-binding site [ion binding]; other site
863767000040	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
863767000041	DNA gyrase subunit A; Validated; Region: PRK05560
863767000042	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
863767000043	CAP-like domain; other site
863767000044	active site
863767000045	primary dimer interface [polypeptide binding]; other site
863767000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
863767000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
863767000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
863767000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
863767000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
863767000051	cardiolipin synthetase; Reviewed; Region: PRK12452
863767000052	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
863767000053	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
863767000054	putative active site [active]
863767000055	catalytic site [active]
863767000056	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
863767000057	putative active site [active]
863767000058	catalytic site [active]
863767000059	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
863767000060	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767000061	Coenzyme A binding pocket [chemical binding]; other site
863767000062	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
863767000063	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
863767000064	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
863767000065	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
863767000066	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
863767000067	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
863767000068	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
863767000069	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
863767000070	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
863767000071	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
863767000072	D-pathway; other site
863767000073	Putative ubiquinol binding site [chemical binding]; other site
863767000074	Low-spin heme (heme b) binding site [chemical binding]; other site
863767000075	Putative water exit pathway; other site
863767000076	Binuclear center (heme o3/CuB) [ion binding]; other site
863767000077	K-pathway; other site
863767000078	Putative proton exit pathway; other site
863767000079	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
863767000080	Subunit I/III interface [polypeptide binding]; other site
863767000081	Subunit III/IV interface [polypeptide binding]; other site
863767000082	cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901
863767000083	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
863767000084	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
863767000085	putative active site [active]
863767000086	putative metal binding site [ion binding]; other site
863767000087	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
863767000088	beta-galactosidase; Region: BGL; TIGR03356
863767000089	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
863767000090	Bacterial SH3 domain; Region: SH3_3; pfam08239
863767000091	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
863767000092	putative active site [active]
863767000093	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
863767000094	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767000095	DNA-binding site [nucleotide binding]; DNA binding site
863767000096	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
863767000097	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
863767000098	active site
863767000099	active pocket/dimerization site; other site
863767000100	phosphorylation site [posttranslational modification]
863767000101	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
863767000102	active site
863767000103	phosphorylation site [posttranslational modification]
863767000104	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
863767000105	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
863767000106	hypothetical protein; Provisional; Region: PRK02947
863767000107	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
863767000108	putative active site [active]
863767000109	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
863767000110	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
863767000111	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
863767000112	active site turn [active]
863767000113	phosphorylation site [posttranslational modification]
863767000114	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
863767000115	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
863767000116	HPr interaction site; other site
863767000117	glycerol kinase (GK) interaction site [polypeptide binding]; other site
863767000118	active site
863767000119	phosphorylation site [posttranslational modification]
863767000120	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
863767000121	putative dimer interface [polypeptide binding]; other site
863767000122	catalytic triad [active]
863767000123	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
863767000124	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767000125	Walker A/P-loop; other site
863767000126	ATP binding site [chemical binding]; other site
863767000127	Q-loop/lid; other site
863767000128	ABC transporter signature motif; other site
863767000129	Walker B; other site
863767000130	D-loop; other site
863767000131	H-loop/switch region; other site
863767000132	Protein of unknown function (DUF2705); Region: DUF2705; pfam10920
863767000133	Protein of unknown function (DUF2712); Region: DUF2712; pfam10916
863767000134	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
863767000135	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767000136	active site
863767000137	motif I; other site
863767000138	motif II; other site
863767000139	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767000140	Transcriptional regulators [Transcription]; Region: PurR; COG1609
863767000141	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
863767000142	DNA binding site [nucleotide binding]
863767000143	domain linker motif; other site
863767000144	Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
863767000145	dimerization interface [polypeptide binding]; other site
863767000146	putative ligand binding site [chemical binding]; other site
863767000147	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
863767000148	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
863767000149	nucleotide binding site [chemical binding]; other site
863767000150	Butyrate kinase [Energy production and conversion]; Region: COG3426
863767000151	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
863767000152	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
863767000153	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
863767000154	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
863767000155	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
863767000156	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
863767000157	dimer interface [polypeptide binding]; other site
863767000158	active site
863767000159	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
863767000160	dimer interface [polypeptide binding]; other site
863767000161	active site
863767000162	putrescine carbamoyltransferase; Provisional; Region: PRK02255
863767000163	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
863767000164	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
863767000165	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
863767000166	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
863767000167	agmatine deiminase; Provisional; Region: PRK13551
863767000168	agmatine deiminase; Region: agmatine_aguA; TIGR03380
863767000169	carbamate kinase; Reviewed; Region: PRK12686
863767000170	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
863767000171	putative substrate binding site [chemical binding]; other site
863767000172	nucleotide binding site [chemical binding]; other site
863767000173	nucleotide binding site [chemical binding]; other site
863767000174	homodimer interface [polypeptide binding]; other site
863767000175	agmatine deiminase; Provisional; Region: PRK13551
863767000176	agmatine deiminase; Region: agmatine_aguA; TIGR03380
863767000177	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
863767000178	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
863767000179	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
863767000180	putative active site [active]
863767000181	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
863767000182	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
863767000183	arginine deiminase; Provisional; Region: PRK01388
863767000184	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
863767000185	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
863767000186	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
863767000187	dimer interface [polypeptide binding]; other site
863767000188	ssDNA binding site [nucleotide binding]; other site
863767000189	tetramer (dimer of dimers) interface [polypeptide binding]; other site
863767000190	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
863767000191	Predicted membrane protein [Function unknown]; Region: COG3212
863767000192	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
863767000193	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
863767000194	putative accessory gene regulator protein; Provisional; Region: PRK01100
863767000195	Staphylococcal AgrD protein; Region: AgrD; cl05477
863767000196	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
863767000197	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767000198	ATP binding site [chemical binding]; other site
863767000199	Mg2+ binding site [ion binding]; other site
863767000200	G-X-G motif; other site
863767000201	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
863767000202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767000203	active site
863767000204	phosphorylation site [posttranslational modification]
863767000205	intermolecular recognition site; other site
863767000206	LytTr DNA-binding domain; Region: LytTR; pfam04397
863767000207	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
863767000208	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
863767000209	DHH family; Region: DHH; pfam01368
863767000210	DHHA1 domain; Region: DHHA1; pfam02272
863767000211	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
863767000212	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
863767000213	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
863767000214	replicative DNA helicase; Provisional; Region: PRK05748
863767000215	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
863767000216	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
863767000217	Walker A motif; other site
863767000218	ATP binding site [chemical binding]; other site
863767000219	Walker B motif; other site
863767000220	DNA binding loops [nucleotide binding]
863767000221	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
863767000222	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
863767000223	GDP-binding site [chemical binding]; other site
863767000224	ACT binding site; other site
863767000225	IMP binding site; other site
863767000226	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
863767000227	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
863767000228	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
863767000229	Predicted membrane protein [Function unknown]; Region: COG1511
863767000230	Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858
863767000231	WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266
863767000232	WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266
863767000233	Uncharacterized small protein [Function unknown]; Region: COG5417
863767000234	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868
863767000235	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
863767000236	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
863767000237	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
863767000238	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
863767000239	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
863767000240	LXG domain of WXG superfamily; Region: LXG; pfam04740
863767000241	Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013
863767000242	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
863767000243	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
863767000244	tetramer interface [polypeptide binding]; other site
863767000245	active site
863767000246	Mg2+/Mn2+ binding site [ion binding]; other site
863767000247	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
863767000248	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
863767000249	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
863767000250	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
863767000251	DNA binding site [nucleotide binding]
863767000252	active site
863767000253	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
863767000254	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
863767000255	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
863767000256	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
863767000257	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
863767000258	putative ligand binding site [chemical binding]; other site
863767000259	putative NAD binding site [chemical binding]; other site
863767000260	catalytic site [active]
863767000261	LXG domain of WXG superfamily; Region: LXG; pfam04740
863767000262	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
863767000263	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
863767000264	DNA binding residues [nucleotide binding]
863767000265	putative dimer interface [polypeptide binding]; other site
863767000266	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
863767000267	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
863767000268	active site
863767000269	catalytic tetrad [active]
863767000270	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767000271	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
863767000272	ATP synthase subunit C; Region: ATP-synt_C; cl00466
863767000273	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
863767000274	F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343
863767000275	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
863767000276	Walker A motif; other site
863767000277	ATP binding site [chemical binding]; other site
863767000278	Walker B motif; other site
863767000279	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
863767000280	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
863767000281	core domain interface [polypeptide binding]; other site
863767000282	delta subunit interface [polypeptide binding]; other site
863767000283	epsilon subunit interface [polypeptide binding]; other site
863767000284	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
863767000285	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
863767000286	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
863767000287	alpha subunit interaction interface [polypeptide binding]; other site
863767000288	Walker A motif; other site
863767000289	ATP binding site [chemical binding]; other site
863767000290	Walker B motif; other site
863767000291	inhibitor binding site; inhibition site
863767000292	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
863767000293	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823
863767000294	gamma subunit interface [polypeptide binding]; other site
863767000295	epsilon subunit interface [polypeptide binding]; other site
863767000296	LBP interface [polypeptide binding]; other site
863767000297	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
863767000298	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
863767000299	active pocket/dimerization site; other site
863767000300	active site
863767000301	phosphorylation site [posttranslational modification]
863767000302	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
863767000303	active site
863767000304	phosphorylation site [posttranslational modification]
863767000305	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
863767000306	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
863767000307	Domain of unknown function (DUF956); Region: DUF956; pfam06115
863767000308	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
863767000309	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
863767000310	dimerization interface [polypeptide binding]; other site
863767000311	putative DNA binding site [nucleotide binding]; other site
863767000312	putative Zn2+ binding site [ion binding]; other site
863767000313	Uncharacterized conserved protein [Function unknown]; Region: COG1359
863767000314	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
863767000315	dimer interface [polypeptide binding]; other site
863767000316	FMN binding site [chemical binding]; other site
863767000317	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
863767000318	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
863767000319	active site
863767000320	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
863767000321	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
863767000322	Interdomain contacts; other site
863767000323	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
863767000324	aromatic chitin/cellulose binding site residues [chemical binding]; other site
863767000325	Protein of unknown function (DUF3130; Region: DUF3130; pfam11328
863767000326	LXG domain of WXG superfamily; Region: LXG; pfam04740
863767000327	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
863767000328	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
863767000329	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
863767000330	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
863767000331	Walker A/P-loop; other site
863767000332	ATP binding site [chemical binding]; other site
863767000333	Q-loop/lid; other site
863767000334	ABC transporter signature motif; other site
863767000335	Walker B; other site
863767000336	D-loop; other site
863767000337	H-loop/switch region; other site
863767000338	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
863767000339	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
863767000340	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
863767000341	Walker A/P-loop; other site
863767000342	ATP binding site [chemical binding]; other site
863767000343	Q-loop/lid; other site
863767000344	ABC transporter signature motif; other site
863767000345	Walker B; other site
863767000346	D-loop; other site
863767000347	H-loop/switch region; other site
863767000348	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
863767000349	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
863767000350	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
863767000351	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
863767000352	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
863767000353	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
863767000354	substrate binding pocket [chemical binding]; other site
863767000355	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
863767000356	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
863767000357	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767000358	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
863767000359	ligand binding site [chemical binding]; other site
863767000360	flexible hinge region; other site
863767000361	Domain of unknown function (DUF955); Region: DUF955; pfam06114
863767000362	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767000363	non-specific DNA binding site [nucleotide binding]; other site
863767000364	salt bridge; other site
863767000365	sequence-specific DNA binding site [nucleotide binding]; other site
863767000366	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
863767000367	Predicted secreted protein [Function unknown]; Region: COG5437
863767000368	Phage-related protein [Function unknown]; Region: COG5412
863767000369	Phage tail protein; Region: Sipho_tail; pfam05709
863767000370	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
863767000371	Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824
863767000372	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
863767000373	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
863767000374	active site
863767000375	metal binding site [ion binding]; metal-binding site
863767000376	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
863767000377	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
863767000378	putative active site [active]
863767000379	putative metal binding site [ion binding]; other site
863767000380	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
863767000381	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
863767000382	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107
863767000383	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
863767000384	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602
863767000385	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
863767000386	active site
863767000387	Uncharacterized conserved protein [Function unknown]; Region: COG3592
863767000388	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767000389	Coenzyme A binding pocket [chemical binding]; other site
863767000390	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
863767000391	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
863767000392	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
863767000393	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767000394	dimer interface [polypeptide binding]; other site
863767000395	conserved gate region; other site
863767000396	putative PBP binding loops; other site
863767000397	ABC-ATPase subunit interface; other site
863767000398	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
863767000399	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
863767000400	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767000401	dimer interface [polypeptide binding]; other site
863767000402	conserved gate region; other site
863767000403	putative PBP binding loops; other site
863767000404	ABC-ATPase subunit interface; other site
863767000405	Protein of unknown function (DUF3130; Region: DUF3130; cl12867
863767000406	LXG domain of WXG superfamily; Region: LXG; pfam04740
863767000407	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
863767000408	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
863767000409	peptide binding site [polypeptide binding]; other site
863767000410	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
863767000411	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
863767000412	metal binding site [ion binding]; metal-binding site
863767000413	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
863767000414	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
863767000415	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
863767000416	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
863767000417	ABC-ATPase subunit  interface; other site
863767000418	dimer interface [polypeptide binding]; other site
863767000419	putative PBP binding regions; other site
863767000420	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
863767000421	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767000422	ligand binding site [chemical binding]; other site
863767000423	flexible hinge region; other site
863767000424	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
863767000425	DEAD_2; Region: DEAD_2; pfam06733
863767000426	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
863767000427	sugar phosphate phosphatase; Provisional; Region: PRK10513
863767000428	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767000429	active site
863767000430	motif I; other site
863767000431	motif II; other site
863767000432	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767000433	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
863767000434	Collagen binding domain; Region: Collagen_bind; pfam05737
863767000435	Cna protein B-type domain; Region: Cna_B; pfam05738
863767000436	Cna protein B-type domain; Region: Cna_B; pfam05738
863767000437	Cna protein B-type domain; Region: Cna_B; pfam05738
863767000438	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
863767000439	Collagen binding domain; Region: Collagen_bind; pfam05737
863767000440	Cna protein B-type domain; Region: Cna_B; pfam05738
863767000441	Cna protein B-type domain; Region: Cna_B; pfam05738
863767000442	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
863767000443	DNA polymerase III subunit delta'; Validated; Region: PRK08058
863767000444	DNA polymerase III subunit delta'; Validated; Region: PRK08485
863767000445	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
863767000446	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467
863767000447	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
863767000448	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767000449	S-adenosylmethionine binding site [chemical binding]; other site
863767000450	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
863767000451	GIY-YIG motif/motif A; other site
863767000452	putative active site [active]
863767000453	putative metal binding site [ion binding]; other site
863767000454	Predicted methyltransferases [General function prediction only]; Region: COG0313
863767000455	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
863767000456	putative SAM binding site [chemical binding]; other site
863767000457	putative homodimer interface [polypeptide binding]; other site
863767000458	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
863767000459	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
863767000460	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
863767000461	Uncharacterized conserved protein [Function unknown]; Region: COG5361
863767000462	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
863767000463	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
863767000464	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767000465	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
863767000466	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
863767000467	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
863767000468	active site
863767000469	HIGH motif; other site
863767000470	KMSKS motif; other site
863767000471	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
863767000472	tRNA binding surface [nucleotide binding]; other site
863767000473	anticodon binding site; other site
863767000474	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
863767000475	dimer interface [polypeptide binding]; other site
863767000476	putative tRNA-binding site [nucleotide binding]; other site
863767000477	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
863767000478	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
863767000479	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
863767000480	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
863767000481	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
863767000482	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767000483	dimer interface [polypeptide binding]; other site
863767000484	conserved gate region; other site
863767000485	putative PBP binding loops; other site
863767000486	ABC-ATPase subunit interface; other site
863767000487	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
863767000488	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767000489	dimer interface [polypeptide binding]; other site
863767000490	conserved gate region; other site
863767000491	putative PBP binding loops; other site
863767000492	ABC-ATPase subunit interface; other site
863767000493	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
863767000494	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
863767000495	alpha-glucosidase; Provisional; Region: PRK10426
863767000496	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
863767000497	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
863767000498	active site
863767000499	catalytic site [active]
863767000500	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
863767000501	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
863767000502	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
863767000503	trimer interface [polypeptide binding]; other site
863767000504	active site
863767000505	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
863767000506	catalytic site [active]
863767000507	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
863767000508	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
863767000509	Ca binding site [ion binding]; other site
863767000510	active site
863767000511	catalytic site [active]
863767000512	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
863767000513	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
863767000514	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
863767000515	active site
863767000516	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
863767000517	Domain of unknown function (DUF348); Region: DUF348; pfam03990
863767000518	Domain of unknown function (DUF348); Region: DUF348; pfam03990
863767000519	G5 domain; Region: G5; pfam07501
863767000520	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
863767000521	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
863767000522	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
863767000523	putative active site [active]
863767000524	putative metal binding site [ion binding]; other site
863767000525	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
863767000526	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
863767000527	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767000528	S-adenosylmethionine binding site [chemical binding]; other site
863767000529	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
863767000530	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
863767000531	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
863767000532	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
863767000533	putative active site [active]
863767000534	YdjC motif; other site
863767000535	Mg binding site [ion binding]; other site
863767000536	putative homodimer interface [polypeptide binding]; other site
863767000537	pur operon repressor; Provisional; Region: PRK09213
863767000538	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
863767000539	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
863767000540	active site
863767000541	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
863767000542	HlyD family secretion protein; Region: HlyD_3; pfam13437
863767000543	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
863767000544	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
863767000545	Walker A/P-loop; other site
863767000546	ATP binding site [chemical binding]; other site
863767000547	Q-loop/lid; other site
863767000548	ABC transporter signature motif; other site
863767000549	Walker B; other site
863767000550	D-loop; other site
863767000551	H-loop/switch region; other site
863767000552	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
863767000553	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
863767000554	FtsX-like permease family; Region: FtsX; pfam02687
863767000555	regulatory protein SpoVG; Reviewed; Region: PRK13259
863767000556	regulatory protein SpoVG; Reviewed; Region: PRK13259
863767000557	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
863767000558	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
863767000559	Substrate binding site; other site
863767000560	Mg++ binding site; other site
863767000561	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
863767000562	active site
863767000563	substrate binding site [chemical binding]; other site
863767000564	CoA binding site [chemical binding]; other site
863767000565	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
863767000566	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
863767000567	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
863767000568	active site
863767000569	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767000570	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
863767000571	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
863767000572	Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137
863767000573	active site
863767000574	catalytic site [active]
863767000575	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
863767000576	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
863767000577	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
863767000578	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
863767000579	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
863767000580	active site
863767000581	Zn binding site [ion binding]; other site
863767000582	ActA Protein; Region: ActA; pfam05058
863767000583	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
863767000584	Zn binding site [ion binding]; other site
863767000585	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
863767000586	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
863767000587	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
863767000588	A new structural DNA glycosylase; Region: AlkD_like; cd06561
863767000589	active site
863767000590	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
863767000591	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
863767000592	tetramer (dimer of dimers) interface [polypeptide binding]; other site
863767000593	NAD binding site [chemical binding]; other site
863767000594	dimer interface [polypeptide binding]; other site
863767000595	substrate binding site [chemical binding]; other site
863767000596	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
863767000597	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
863767000598	5S rRNA interface [nucleotide binding]; other site
863767000599	CTC domain interface [polypeptide binding]; other site
863767000600	L16 interface [polypeptide binding]; other site
863767000601	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
863767000602	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767000603	Coenzyme A binding pocket [chemical binding]; other site
863767000604	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
863767000605	putative active site [active]
863767000606	catalytic residue [active]
863767000607	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
863767000608	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
863767000609	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
863767000610	ATP binding site [chemical binding]; other site
863767000611	putative Mg++ binding site [ion binding]; other site
863767000612	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
863767000613	nucleotide binding region [chemical binding]; other site
863767000614	ATP-binding site [chemical binding]; other site
863767000615	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
863767000616	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
863767000617	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
863767000618	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
863767000619	RNA binding surface [nucleotide binding]; other site
863767000620	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
863767000621	Septum formation initiator; Region: DivIC; pfam04977
863767000622	hypothetical protein; Provisional; Region: PRK08582
863767000623	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
863767000624	RNA binding site [nucleotide binding]; other site
863767000625	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
863767000626	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
863767000627	Ligand Binding Site [chemical binding]; other site
863767000628	TilS substrate C-terminal domain; Region: TilS_C; smart00977
863767000629	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
863767000630	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
863767000631	active site
863767000632	FtsH Extracellular; Region: FtsH_ext; pfam06480
863767000633	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
863767000634	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767000635	Walker A motif; other site
863767000636	ATP binding site [chemical binding]; other site
863767000637	Walker B motif; other site
863767000638	arginine finger; other site
863767000639	Peptidase family M41; Region: Peptidase_M41; pfam01434
863767000640	pantothenate kinase; Reviewed; Region: PRK13318
863767000641	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
863767000642	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
863767000643	dimerization interface [polypeptide binding]; other site
863767000644	domain crossover interface; other site
863767000645	redox-dependent activation switch; other site
863767000646	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
863767000647	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
863767000648	dimer interface [polypeptide binding]; other site
863767000649	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767000650	catalytic residue [active]
863767000651	dihydropteroate synthase; Region: DHPS; TIGR01496
863767000652	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
863767000653	substrate binding pocket [chemical binding]; other site
863767000654	dimer interface [polypeptide binding]; other site
863767000655	inhibitor binding site; inhibition site
863767000656	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
863767000657	homooctamer interface [polypeptide binding]; other site
863767000658	active site
863767000659	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
863767000660	catalytic center binding site [active]
863767000661	ATP binding site [chemical binding]; other site
863767000662	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
863767000663	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
863767000664	FMN binding site [chemical binding]; other site
863767000665	active site
863767000666	catalytic residues [active]
863767000667	substrate binding site [chemical binding]; other site
863767000668	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
863767000669	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
863767000670	dimer interface [polypeptide binding]; other site
863767000671	putative anticodon binding site; other site
863767000672	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
863767000673	motif 1; other site
863767000674	active site
863767000675	motif 2; other site
863767000676	motif 3; other site
863767000677	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
863767000678	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
863767000679	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
863767000680	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
863767000681	ADP binding site [chemical binding]; other site
863767000682	phosphagen binding site; other site
863767000683	substrate specificity loop; other site
863767000684	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
863767000685	Clp amino terminal domain; Region: Clp_N; pfam02861
863767000686	Clp amino terminal domain; Region: Clp_N; pfam02861
863767000687	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767000688	Walker A motif; other site
863767000689	ATP binding site [chemical binding]; other site
863767000690	Walker B motif; other site
863767000691	arginine finger; other site
863767000692	UvrB/uvrC motif; Region: UVR; pfam02151
863767000693	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767000694	Walker A motif; other site
863767000695	ATP binding site [chemical binding]; other site
863767000696	Walker B motif; other site
863767000697	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
863767000698	DNA repair protein RadA; Provisional; Region: PRK11823
863767000699	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
863767000700	Walker A motif/ATP binding site; other site
863767000701	ATP binding site [chemical binding]; other site
863767000702	Walker B motif; other site
863767000703	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
863767000704	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
863767000705	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
863767000706	putative active site [active]
863767000707	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
863767000708	substrate binding site; other site
863767000709	dimer interface; other site
863767000710	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
863767000711	homotrimer interaction site [polypeptide binding]; other site
863767000712	zinc binding site [ion binding]; other site
863767000713	CDP-binding sites; other site
863767000714	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
863767000715	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
863767000716	HIGH motif; other site
863767000717	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
863767000718	active site
863767000719	KMSKS motif; other site
863767000720	serine O-acetyltransferase; Region: cysE; TIGR01172
863767000721	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
863767000722	trimer interface [polypeptide binding]; other site
863767000723	active site
863767000724	substrate binding site [chemical binding]; other site
863767000725	CoA binding site [chemical binding]; other site
863767000726	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
863767000727	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
863767000728	active site
863767000729	HIGH motif; other site
863767000730	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
863767000731	KMSKS motif; other site
863767000732	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
863767000733	tRNA binding surface [nucleotide binding]; other site
863767000734	anticodon binding site; other site
863767000735	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
863767000736	active site
863767000737	metal binding site [ion binding]; metal-binding site
863767000738	dimerization interface [polypeptide binding]; other site
863767000739	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
863767000740	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
863767000741	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
863767000742	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
863767000743	RNA polymerase factor sigma-70; Validated; Region: PRK08295
863767000744	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
863767000745	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
863767000746	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
863767000747	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
863767000748	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
863767000749	putative homodimer interface [polypeptide binding]; other site
863767000750	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
863767000751	heterodimer interface [polypeptide binding]; other site
863767000752	homodimer interface [polypeptide binding]; other site
863767000753	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
863767000754	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
863767000755	23S rRNA interface [nucleotide binding]; other site
863767000756	L7/L12 interface [polypeptide binding]; other site
863767000757	putative thiostrepton binding site; other site
863767000758	L25 interface [polypeptide binding]; other site
863767000759	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
863767000760	mRNA/rRNA interface [nucleotide binding]; other site
863767000761	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
863767000762	23S rRNA interface [nucleotide binding]; other site
863767000763	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
863767000764	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
863767000765	core dimer interface [polypeptide binding]; other site
863767000766	peripheral dimer interface [polypeptide binding]; other site
863767000767	L10 interface [polypeptide binding]; other site
863767000768	L11 interface [polypeptide binding]; other site
863767000769	putative EF-Tu interaction site [polypeptide binding]; other site
863767000770	putative EF-G interaction site [polypeptide binding]; other site
863767000771	Methyltransferase domain; Region: Methyltransf_31; pfam13847
863767000772	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767000773	S-adenosylmethionine binding site [chemical binding]; other site
863767000774	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
863767000775	Transcriptional regulators [Transcription]; Region: PurR; COG1609
863767000776	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
863767000777	DNA binding site [nucleotide binding]
863767000778	domain linker motif; other site
863767000779	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
863767000780	putative dimerization interface [polypeptide binding]; other site
863767000781	putative ligand binding site [chemical binding]; other site
863767000782	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
863767000783	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
863767000784	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
863767000785	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767000786	dimer interface [polypeptide binding]; other site
863767000787	conserved gate region; other site
863767000788	putative PBP binding loops; other site
863767000789	ABC-ATPase subunit interface; other site
863767000790	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
863767000791	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767000792	dimer interface [polypeptide binding]; other site
863767000793	conserved gate region; other site
863767000794	putative PBP binding loops; other site
863767000795	ABC-ATPase subunit interface; other site
863767000796	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
863767000797	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
863767000798	Ca binding site [ion binding]; other site
863767000799	active site
863767000800	catalytic site [active]
863767000801	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
863767000802	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
863767000803	active site
863767000804	homodimer interface [polypeptide binding]; other site
863767000805	catalytic site [active]
863767000806	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
863767000807	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
863767000808	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
863767000809	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
863767000810	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
863767000811	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
863767000812	RPB10 interaction site [polypeptide binding]; other site
863767000813	RPB1 interaction site [polypeptide binding]; other site
863767000814	RPB11 interaction site [polypeptide binding]; other site
863767000815	RPB3 interaction site [polypeptide binding]; other site
863767000816	RPB12 interaction site [polypeptide binding]; other site
863767000817	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
863767000818	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
863767000819	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
863767000820	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
863767000821	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
863767000822	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
863767000823	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
863767000824	G-loop; other site
863767000825	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
863767000826	DNA binding site [nucleotide binding]
863767000827	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
863767000828	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
863767000829	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767000830	active site
863767000831	motif I; other site
863767000832	motif II; other site
863767000833	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
863767000834	beta-galactosidase; Region: BGL; TIGR03356
863767000835	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
863767000836	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
863767000837	Walker A/P-loop; other site
863767000838	ATP binding site [chemical binding]; other site
863767000839	Q-loop/lid; other site
863767000840	ABC transporter signature motif; other site
863767000841	Walker B; other site
863767000842	D-loop; other site
863767000843	H-loop/switch region; other site
863767000844	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
863767000845	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
863767000846	Walker A/P-loop; other site
863767000847	ATP binding site [chemical binding]; other site
863767000848	Q-loop/lid; other site
863767000849	ABC transporter signature motif; other site
863767000850	Walker B; other site
863767000851	D-loop; other site
863767000852	H-loop/switch region; other site
863767000853	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
863767000854	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
863767000855	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
863767000856	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
863767000857	LRR adjacent; Region: LRR_adjacent; pfam08191
863767000858	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767000859	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767000860	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
863767000861	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
863767000862	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000863	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000864	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000865	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000866	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000867	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000868	LRR adjacent; Region: LRR_adjacent; pfam08191
863767000869	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767000870	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767000871	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
863767000872	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000873	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000874	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
863767000875	Leucine-rich repeats; other site
863767000876	Substrate binding site [chemical binding]; other site
863767000877	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000878	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000879	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000880	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000881	LRR adjacent; Region: LRR_adjacent; pfam08191
863767000882	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767000883	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767000884	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
863767000885	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
863767000886	metal binding site [ion binding]; metal-binding site
863767000887	dimer interface [polypeptide binding]; other site
863767000888	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
863767000889	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
863767000890	putative Zn2+ binding site [ion binding]; other site
863767000891	putative DNA binding site [nucleotide binding]; other site
863767000892	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
863767000893	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
863767000894	Zn binding site [ion binding]; other site
863767000895	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
863767000896	Zn binding site [ion binding]; other site
863767000897	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
863767000898	catalytic core [active]
863767000899	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
863767000900	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
863767000901	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
863767000902	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767000903	dimer interface [polypeptide binding]; other site
863767000904	conserved gate region; other site
863767000905	ABC-ATPase subunit interface; other site
863767000906	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
863767000907	Substrate binding site [chemical binding]; other site
863767000908	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000909	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000910	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000911	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000912	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767000913	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
863767000914	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
863767000915	beta-galactosidase; Region: BGL; TIGR03356
863767000916	sugar phosphate phosphatase; Provisional; Region: PRK10513
863767000917	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767000918	active site
863767000919	motif I; other site
863767000920	motif II; other site
863767000921	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767000922	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767000923	Coenzyme A binding pocket [chemical binding]; other site
863767000924	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767000925	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
863767000926	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
863767000927	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
863767000928	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767000929	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
863767000930	active site
863767000931	motif I; other site
863767000932	motif II; other site
863767000933	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767000934	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
863767000935	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
863767000936	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
863767000937	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
863767000938	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
863767000939	Walker A/P-loop; other site
863767000940	ATP binding site [chemical binding]; other site
863767000941	Q-loop/lid; other site
863767000942	ABC transporter signature motif; other site
863767000943	Walker B; other site
863767000944	D-loop; other site
863767000945	H-loop/switch region; other site
863767000946	TOBE domain; Region: TOBE; pfam03459
863767000947	ATP cone domain; Region: ATP-cone; pfam03477
863767000948	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
863767000949	Class III ribonucleotide reductase; Region: RNR_III; cd01675
863767000950	effector binding site; other site
863767000951	active site
863767000952	Zn binding site [ion binding]; other site
863767000953	glycine loop; other site
863767000954	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
863767000955	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
863767000956	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767000957	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
863767000958	ligand binding site [chemical binding]; other site
863767000959	flexible hinge region; other site
863767000960	Predicted amidohydrolase [General function prediction only]; Region: COG0388
863767000961	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
863767000962	putative active site [active]
863767000963	catalytic triad [active]
863767000964	putative dimer interface [polypeptide binding]; other site
863767000965	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767000966	dimer interface [polypeptide binding]; other site
863767000967	conserved gate region; other site
863767000968	ABC-ATPase subunit interface; other site
863767000969	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
863767000970	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
863767000971	Walker A/P-loop; other site
863767000972	ATP binding site [chemical binding]; other site
863767000973	Q-loop/lid; other site
863767000974	ABC transporter signature motif; other site
863767000975	Walker B; other site
863767000976	D-loop; other site
863767000977	H-loop/switch region; other site
863767000978	NIL domain; Region: NIL; pfam09383
863767000979	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
863767000980	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
863767000981	transaminase; Reviewed; Region: PRK08068
863767000982	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
863767000983	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767000984	homodimer interface [polypeptide binding]; other site
863767000985	catalytic residue [active]
863767000986	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
863767000987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767000988	active site
863767000989	phosphorylation site [posttranslational modification]
863767000990	intermolecular recognition site; other site
863767000991	dimerization interface [polypeptide binding]; other site
863767000992	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
863767000993	DNA binding site [nucleotide binding]
863767000994	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
863767000995	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
863767000996	dimerization interface [polypeptide binding]; other site
863767000997	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
863767000998	putative active site [active]
863767000999	heme pocket [chemical binding]; other site
863767001000	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
863767001001	dimer interface [polypeptide binding]; other site
863767001002	phosphorylation site [posttranslational modification]
863767001003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767001004	ATP binding site [chemical binding]; other site
863767001005	Mg2+ binding site [ion binding]; other site
863767001006	G-X-G motif; other site
863767001007	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
863767001008	YycH protein; Region: YycH; pfam07435
863767001009	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853
863767001010	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
863767001011	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
863767001012	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
863767001013	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
863767001014	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
863767001015	protein binding site [polypeptide binding]; other site
863767001016	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
863767001017	Transcriptional regulator [Transcription]; Region: LysR; COG0583
863767001018	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
863767001019	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
863767001020	dimerization interface [polypeptide binding]; other site
863767001021	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
863767001022	dimer interface [polypeptide binding]; other site
863767001023	FMN binding site [chemical binding]; other site
863767001024	NADPH bind site [chemical binding]; other site
863767001025	DNA adenine methylase (dam); Region: dam; TIGR00571
863767001026	AIPR protein; Region: AIPR; pfam10592
863767001027	Protein of unknown function (DUF998); Region: DUF998; pfam06197
863767001028	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
863767001029	HTH domain; Region: HTH_11; pfam08279
863767001030	Mga helix-turn-helix domain; Region: Mga; pfam05043
863767001031	PRD domain; Region: PRD; pfam00874
863767001032	PRD domain; Region: PRD; pfam00874
863767001033	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
863767001034	active site
863767001035	P-loop; other site
863767001036	phosphorylation site [posttranslational modification]
863767001037	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767001038	active site
863767001039	phosphorylation site [posttranslational modification]
863767001040	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
863767001041	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
863767001042	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
863767001043	active site
863767001044	P-loop; other site
863767001045	phosphorylation site [posttranslational modification]
863767001046	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
863767001047	beta-galactosidase; Region: BGL; TIGR03356
863767001048	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
863767001049	methionine cluster; other site
863767001050	active site
863767001051	phosphorylation site [posttranslational modification]
863767001052	metal binding site [ion binding]; metal-binding site
863767001053	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
863767001054	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
863767001055	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
863767001056	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
863767001057	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
863767001058	catalytic residue [active]
863767001059	Peptidase family M48; Region: Peptidase_M48; cl12018
863767001060	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
863767001061	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805
863767001062	putative active site [active]
863767001063	YdjC motif; other site
863767001064	Mg binding site [ion binding]; other site
863767001065	putative homodimer interface [polypeptide binding]; other site
863767001066	Putative transcription activator [Transcription]; Region: TenA; COG0819
863767001067	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
863767001068	substrate binding site [chemical binding]; other site
863767001069	multimerization interface [polypeptide binding]; other site
863767001070	ATP binding site [chemical binding]; other site
863767001071	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
863767001072	dimer interface [polypeptide binding]; other site
863767001073	substrate binding site [chemical binding]; other site
863767001074	ATP binding site [chemical binding]; other site
863767001075	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
863767001076	thiamine phosphate binding site [chemical binding]; other site
863767001077	active site
863767001078	pyrophosphate binding site [ion binding]; other site
863767001079	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
863767001080	beta-galactosidase; Region: BGL; TIGR03356
863767001081	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767001082	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
863767001083	Protein of unknown function (DUF1696); Region: DUF1696; pfam08000
863767001084	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
863767001085	putative catalytic site [active]
863767001086	putative metal binding site [ion binding]; other site
863767001087	putative phosphate binding site [ion binding]; other site
863767001088	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767001089	non-specific DNA binding site [nucleotide binding]; other site
863767001090	salt bridge; other site
863767001091	sequence-specific DNA binding site [nucleotide binding]; other site
863767001092	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
863767001093	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767001094	non-specific DNA binding site [nucleotide binding]; other site
863767001095	salt bridge; other site
863767001096	sequence-specific DNA binding site [nucleotide binding]; other site
863767001097	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
863767001098	Leucine rich repeat; Region: LRR_8; pfam13855
863767001099	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001100	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001101	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001102	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001103	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001104	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001105	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001106	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001107	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001108	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001109	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001110	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001111	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001112	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001113	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001114	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001115	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767001116	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001117	Leucine rich repeat; Region: LRR_8; pfam13855
863767001118	LRR adjacent; Region: LRR_adjacent; pfam08191
863767001119	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767001120	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
863767001121	Leucine-rich repeats; other site
863767001122	Substrate binding site [chemical binding]; other site
863767001123	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001124	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001125	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001126	Leucine rich repeat; Region: LRR_8; pfam13855
863767001127	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
863767001128	Leucine-rich repeats; other site
863767001129	Leucine rich repeat; Region: LRR_8; pfam13855
863767001130	Substrate binding site [chemical binding]; other site
863767001131	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001132	Leucine rich repeat; Region: LRR_8; pfam13855
863767001133	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001134	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001135	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001136	LRR adjacent; Region: LRR_adjacent; pfam08191
863767001137	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001138	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001139	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001140	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
863767001141	Protein of unknown function (DUF3130; Region: DUF3130; pfam11328
863767001142	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
863767001143	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
863767001144	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
863767001145	TPP-binding site [chemical binding]; other site
863767001146	dimer interface [polypeptide binding]; other site
863767001147	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
863767001148	PYR/PP interface [polypeptide binding]; other site
863767001149	dimer interface [polypeptide binding]; other site
863767001150	TPP binding site [chemical binding]; other site
863767001151	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
863767001152	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
863767001153	active site
863767001154	intersubunit interactions; other site
863767001155	catalytic residue [active]
863767001156	short chain dehydrogenase; Provisional; Region: PRK06841
863767001157	classical (c) SDRs; Region: SDR_c; cd05233
863767001158	NAD(P) binding site [chemical binding]; other site
863767001159	active site
863767001160	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
863767001161	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
863767001162	substrate binding site [chemical binding]; other site
863767001163	dimer interface [polypeptide binding]; other site
863767001164	catalytic triad [active]
863767001165	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
863767001166	DAK2 domain; Region: Dak2; cl03685
863767001167	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
863767001168	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
863767001169	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
863767001170	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
863767001171	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
863767001172	putative DNA binding site [nucleotide binding]; other site
863767001173	putative Zn2+ binding site [ion binding]; other site
863767001174	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
863767001175	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767001176	Coenzyme A binding pocket [chemical binding]; other site
863767001177	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
863767001178	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
863767001179	LRR adjacent; Region: LRR_adjacent; pfam08191
863767001180	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767001181	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767001182	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
863767001183	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
863767001184	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
863767001185	acyl-activating enzyme (AAE) consensus motif; other site
863767001186	acyl-activating enzyme (AAE) consensus motif; other site
863767001187	AMP binding site [chemical binding]; other site
863767001188	active site
863767001189	CoA binding site [chemical binding]; other site
863767001190	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
863767001191	L-aspartate oxidase; Provisional; Region: PRK06175
863767001192	putative oxidoreductase; Provisional; Region: PRK10206
863767001193	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
863767001194	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
863767001195	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767001196	active site
863767001197	phosphorylation site [posttranslational modification]
863767001198	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
863767001199	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
863767001200	active site
863767001201	P-loop; other site
863767001202	phosphorylation site [posttranslational modification]
863767001203	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
863767001204	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
863767001205	intersubunit interface [polypeptide binding]; other site
863767001206	active site
863767001207	zinc binding site [ion binding]; other site
863767001208	Na+ binding site [ion binding]; other site
863767001209	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
863767001210	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
863767001211	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
863767001212	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
863767001213	conserved cys residue [active]
863767001214	Predicted transcriptional regulator [Transcription]; Region: COG2378
863767001215	HTH domain; Region: HTH_11; pfam08279
863767001216	WYL domain; Region: WYL; pfam13280
863767001217	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693
863767001218	nudix motif; other site
863767001219	hypothetical protein; Provisional; Region: PRK12378
863767001220	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
863767001221	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
863767001222	PhnA protein; Region: PhnA; pfam03831
863767001223	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
863767001224	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767001225	DNA-binding site [nucleotide binding]; DNA binding site
863767001226	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
863767001227	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
863767001228	beta-galactosidase; Region: BGL; TIGR03356
863767001229	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
863767001230	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
863767001231	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
863767001232	active site
863767001233	P-loop; other site
863767001234	phosphorylation site [posttranslational modification]
863767001235	Predicted transcriptional regulator [Transcription]; Region: COG2378
863767001236	HTH domain; Region: HTH_11; pfam08279
863767001237	WYL domain; Region: WYL; pfam13280
863767001238	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
863767001239	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
863767001240	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
863767001241	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
863767001242	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
863767001243	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
863767001244	tetrameric interface [polypeptide binding]; other site
863767001245	NAD binding site [chemical binding]; other site
863767001246	catalytic residues [active]
863767001247	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
863767001248	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
863767001249	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
863767001250	substrate binding site [chemical binding]; other site
863767001251	ATP binding site [chemical binding]; other site
863767001252	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
863767001253	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
863767001254	PYR/PP interface [polypeptide binding]; other site
863767001255	dimer interface [polypeptide binding]; other site
863767001256	TPP binding site [chemical binding]; other site
863767001257	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
863767001258	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
863767001259	TPP-binding site; other site
863767001260	Uncharacterized conserved protein [Function unknown]; Region: COG5646
863767001261	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
863767001262	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
863767001263	ligand binding site [chemical binding]; other site
863767001264	active site
863767001265	UGI interface [polypeptide binding]; other site
863767001266	catalytic site [active]
863767001267	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
863767001268	hypothetical protein; Provisional; Region: PRK13665
863767001269	Bacterial SH3 domain; Region: SH3_3; cl17532
863767001270	NlpC/P60 family; Region: NLPC_P60; pfam00877
863767001271	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
863767001272	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767001273	Coenzyme A binding pocket [chemical binding]; other site
863767001274	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
863767001275	pyrroline-5-carboxylate reductase; Region: PLN02688
863767001276	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767001277	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767001278	Transcriptional regulators [Transcription]; Region: GntR; COG1802
863767001279	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767001280	DNA-binding site [nucleotide binding]; DNA binding site
863767001281	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
863767001282	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
863767001283	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
863767001284	Walker A/P-loop; other site
863767001285	ATP binding site [chemical binding]; other site
863767001286	Q-loop/lid; other site
863767001287	ABC transporter signature motif; other site
863767001288	Walker B; other site
863767001289	D-loop; other site
863767001290	H-loop/switch region; other site
863767001291	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
863767001292	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
863767001293	FtsX-like permease family; Region: FtsX; pfam02687
863767001294	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
863767001295	putative hydrophobic ligand binding site [chemical binding]; other site
863767001296	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767001297	active site
863767001298	phosphorylation site [posttranslational modification]
863767001299	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
863767001300	active site
863767001301	P-loop; other site
863767001302	phosphorylation site [posttranslational modification]
863767001303	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
863767001304	alpha-mannosidase; Provisional; Region: PRK09819
863767001305	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
863767001306	active site
863767001307	metal binding site [ion binding]; metal-binding site
863767001308	catalytic site [active]
863767001309	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
863767001310	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
863767001311	HTH domain; Region: HTH_11; pfam08279
863767001312	Mga helix-turn-helix domain; Region: Mga; pfam05043
863767001313	PRD domain; Region: PRD; pfam00874
863767001314	PRD domain; Region: PRD; pfam00874
863767001315	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
863767001316	active site
863767001317	P-loop; other site
863767001318	phosphorylation site [posttranslational modification]
863767001319	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767001320	active site
863767001321	phosphorylation site [posttranslational modification]
863767001322	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
863767001323	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
863767001324	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
863767001325	putative metal binding site [ion binding]; other site
863767001326	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835
863767001327	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
863767001328	trimer interface [polypeptide binding]; other site
863767001329	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
863767001330	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001331	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
863767001332	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001333	Leucine-rich repeats; other site
863767001334	Substrate binding site [chemical binding]; other site
863767001335	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001336	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001337	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001338	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001339	LRR adjacent; Region: LRR_adjacent; pfam08191
863767001340	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767001341	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767001342	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767001343	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767001344	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767001345	phosphoenolpyruvate synthase; Validated; Region: PRK06241
863767001346	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
863767001347	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
863767001348	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
863767001349	ZIP Zinc transporter; Region: Zip; pfam02535
863767001350	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
863767001351	Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954
863767001352	NodB motif; other site
863767001353	active site
863767001354	catalytic site [active]
863767001355	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767001356	non-specific DNA binding site [nucleotide binding]; other site
863767001357	salt bridge; other site
863767001358	sequence-specific DNA binding site [nucleotide binding]; other site
863767001359	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
863767001360	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
863767001361	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767001362	active site
863767001363	motif I; other site
863767001364	motif II; other site
863767001365	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767001366	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
863767001367	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
863767001368	HTH domain; Region: HTH_11; pfam08279
863767001369	PRD domain; Region: PRD; pfam00874
863767001370	PRD domain; Region: PRD; pfam00874
863767001371	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
863767001372	active site
863767001373	P-loop; other site
863767001374	phosphorylation site [posttranslational modification]
863767001375	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767001376	active site
863767001377	phosphorylation site [posttranslational modification]
863767001378	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767001379	active site
863767001380	phosphorylation site [posttranslational modification]
863767001381	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
863767001382	active site
863767001383	P-loop; other site
863767001384	phosphorylation site [posttranslational modification]
863767001385	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
863767001386	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
863767001387	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
863767001388	active site
863767001389	metal binding site [ion binding]; metal-binding site
863767001390	catalytic site [active]
863767001391	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
863767001392	Transcriptional regulator [Transcription]; Region: LysR; COG0583
863767001393	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
863767001394	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
863767001395	dimerization interface [polypeptide binding]; other site
863767001396	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
863767001397	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
863767001398	active site
863767001399	substrate binding site [chemical binding]; other site
863767001400	trimer interface [polypeptide binding]; other site
863767001401	CoA binding site [chemical binding]; other site
863767001402	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
863767001403	classical (c) SDRs; Region: SDR_c; cd05233
863767001404	NAD(P) binding site [chemical binding]; other site
863767001405	active site
863767001406	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
863767001407	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001408	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
863767001409	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001410	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001411	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001412	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001413	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001414	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001415	LRR adjacent; Region: LRR_adjacent; pfam08191
863767001416	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767001417	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767001418	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767001419	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
863767001420	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
863767001421	Leucine rich repeat; Region: LRR_8; pfam13855
863767001422	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
863767001423	Leucine rich repeat; Region: LRR_8; pfam13855
863767001424	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001425	LRR adjacent; Region: LRR_adjacent; pfam08191
863767001426	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767001427	SH3-like domain; Region: SH3_8; pfam13457
863767001428	Predicted transcriptional regulator [Transcription]; Region: COG1959
863767001429	Transcriptional regulator; Region: Rrf2; pfam02082
863767001430	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
863767001431	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
863767001432	NAD(P) binding site [chemical binding]; other site
863767001433	active site
863767001434	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
863767001435	Protein of unknown function (DUF2004); Region: DUF2004; pfam09406
863767001436	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
863767001437	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
863767001438	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
863767001439	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
863767001440	Transcriptional regulator [Transcription]; Region: LytR; COG1316
863767001441	Predicted membrane protein [Function unknown]; Region: COG1511
863767001442	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
863767001443	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
863767001444	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
863767001445	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
863767001446	Mga helix-turn-helix domain; Region: Mga; pfam05043
863767001447	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
863767001448	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
863767001449	active site
863767001450	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
863767001451	L-tyrosine decarboxylase; Provisional; Region: PRK13520
863767001452	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767001453	catalytic residue [active]
863767001454	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
863767001455	Signal peptide peptidase; Region: Peptidase_A22B; cl01342
863767001456	Predicted membrane protein [Function unknown]; Region: COG3619
863767001457	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
863767001458	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
863767001459	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
863767001460	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
863767001461	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
863767001462	Protein of unknown function DUF58; Region: DUF58; pfam01882
863767001463	MoxR-like ATPases [General function prediction only]; Region: COG0714
863767001464	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767001465	Walker A motif; other site
863767001466	ATP binding site [chemical binding]; other site
863767001467	Walker B motif; other site
863767001468	arginine finger; other site
863767001469	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
863767001470	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
863767001471	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
863767001472	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
863767001473	Na binding site [ion binding]; other site
863767001474	Uncharacterized conserved protein [Function unknown]; Region: COG3535
863767001475	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
863767001476	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
863767001477	nucleotide binding site [chemical binding]; other site
863767001478	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
863767001479	Mga helix-turn-helix domain; Region: Mga; pfam05043
863767001480	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
863767001481	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001482	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001483	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001484	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
863767001485	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001486	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001487	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001488	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001489	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767001490	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
863767001491	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001492	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001493	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001494	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
863767001495	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001496	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001497	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001498	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001499	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001500	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767001501	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
863767001502	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001503	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001504	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001505	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
863767001506	Leucine rich repeat; Region: LRR_8; pfam13855
863767001507	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
863767001508	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
863767001509	Zn2+ binding site [ion binding]; other site
863767001510	Mg2+ binding site [ion binding]; other site
863767001511	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
863767001512	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
863767001513	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
863767001514	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
863767001515	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
863767001516	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
863767001517	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
863767001518	FeS/SAM binding site; other site
863767001519	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
863767001520	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316
863767001521	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
863767001522	active site
863767001523	nucleic acid binding site [nucleotide binding]; other site
863767001524	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
863767001525	putative FMN binding site [chemical binding]; other site
863767001526	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
863767001527	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
863767001528	nudix motif; other site
863767001529	Transcriptional regulator [Transcription]; Region: LysR; COG0583
863767001530	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
863767001531	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
863767001532	putative dimerization interface [polypeptide binding]; other site
863767001533	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
863767001534	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
863767001535	active site
863767001536	FMN binding site [chemical binding]; other site
863767001537	substrate binding site [chemical binding]; other site
863767001538	putative catalytic residue [active]
863767001539	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
863767001540	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
863767001541	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
863767001542	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
863767001543	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
863767001544	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
863767001545	shikimate binding site; other site
863767001546	NAD(P) binding site [chemical binding]; other site
863767001547	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
863767001548	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
863767001549	active site
863767001550	catalytic residue [active]
863767001551	dimer interface [polypeptide binding]; other site
863767001552	Transcriptional regulator [Transcription]; Region: LysR; COG0583
863767001553	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
863767001554	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
863767001555	dimerization interface [polypeptide binding]; other site
863767001556	substrate binding pocket [chemical binding]; other site
863767001557	Predicted acyl esterases [General function prediction only]; Region: COG2936
863767001558	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
863767001559	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
863767001560	active site
863767001561	catalytic triad [active]
863767001562	oxyanion hole [active]
863767001563	EamA-like transporter family; Region: EamA; pfam00892
863767001564	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
863767001565	EamA-like transporter family; Region: EamA; pfam00892
863767001566	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
863767001567	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
863767001568	active site
863767001569	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
863767001570	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
863767001571	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
863767001572	substrate binding site [chemical binding]; other site
863767001573	hexamer interface [polypeptide binding]; other site
863767001574	metal binding site [ion binding]; metal-binding site
863767001575	Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176
863767001576	catalytic residue [active]
863767001577	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
863767001578	PRD domain; Region: PRD; pfam00874
863767001579	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
863767001580	active site
863767001581	P-loop; other site
863767001582	phosphorylation site [posttranslational modification]
863767001583	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767001584	active site
863767001585	phosphorylation site [posttranslational modification]
863767001586	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
863767001587	putative active site [active]
863767001588	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767001589	active site
863767001590	phosphorylation site [posttranslational modification]
863767001591	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
863767001592	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
863767001593	substrate binding site [chemical binding]; other site
863767001594	hexamer interface [polypeptide binding]; other site
863767001595	metal binding site [ion binding]; metal-binding site
863767001596	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
863767001597	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
863767001598	putative NAD(P) binding site [chemical binding]; other site
863767001599	catalytic Zn binding site [ion binding]; other site
863767001600	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
863767001601	active site
863767001602	P-loop; other site
863767001603	phosphorylation site [posttranslational modification]
863767001604	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
863767001605	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
863767001606	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
863767001607	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
863767001608	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
863767001609	active site
863767001610	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
863767001611	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
863767001612	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
863767001613	catalytic triad [active]
863767001614	conserved hypothetical protein; Region: lin0512_fam; TIGR02058
863767001615	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
863767001616	MarR family; Region: MarR_2; pfam12802
863767001617	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001618	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767001619	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
863767001620	Ligand Binding Site [chemical binding]; other site
863767001621	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
863767001622	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
863767001623	putative active site [active]
863767001624	putative metal binding site [ion binding]; other site
863767001625	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
863767001626	catalytic core [active]
863767001627	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
863767001628	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
863767001629	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754
863767001630	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909
863767001631	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
863767001632	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
863767001633	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
863767001634	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
863767001635	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
863767001636	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
863767001637	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
863767001638	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
863767001639	Predicted membrane protein [Function unknown]; Region: COG3759
863767001640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767001641	Major Facilitator Superfamily; Region: MFS_1; pfam07690
863767001642	putative substrate translocation pore; other site
863767001643	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
863767001644	non-specific DNA interactions [nucleotide binding]; other site
863767001645	DNA binding site [nucleotide binding]
863767001646	sequence specific DNA binding site [nucleotide binding]; other site
863767001647	putative cAMP binding site [chemical binding]; other site
863767001648	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
863767001649	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
863767001650	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
863767001651	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
863767001652	NAD binding site [chemical binding]; other site
863767001653	sugar binding site [chemical binding]; other site
863767001654	divalent metal binding site [ion binding]; other site
863767001655	tetramer (dimer of dimers) interface [polypeptide binding]; other site
863767001656	dimer interface [polypeptide binding]; other site
863767001657	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
863767001658	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
863767001659	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
863767001660	putative active site [active]
863767001661	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
863767001662	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
863767001663	Sulfate transporter family; Region: Sulfate_transp; pfam00916
863767001664	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
863767001665	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
863767001666	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
863767001667	DNA binding residues [nucleotide binding]
863767001668	dimer interface [polypeptide binding]; other site
863767001669	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
863767001670	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
863767001671	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
863767001672	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
863767001673	DXD motif; other site
863767001674	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
863767001675	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
863767001676	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
863767001677	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767001678	S-adenosylmethionine binding site [chemical binding]; other site
863767001679	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
863767001680	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
863767001681	Transcriptional regulators [Transcription]; Region: PurR; COG1609
863767001682	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
863767001683	DNA binding site [nucleotide binding]
863767001684	domain linker motif; other site
863767001685	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
863767001686	putative dimerization interface [polypeptide binding]; other site
863767001687	putative ligand binding site [chemical binding]; other site
863767001688	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
863767001689	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
863767001690	NAD binding site [chemical binding]; other site
863767001691	sugar binding site [chemical binding]; other site
863767001692	divalent metal binding site [ion binding]; other site
863767001693	tetramer (dimer of dimers) interface [polypeptide binding]; other site
863767001694	dimer interface [polypeptide binding]; other site
863767001695	allantoate amidohydrolase; Reviewed; Region: PRK09290
863767001696	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
863767001697	active site
863767001698	metal binding site [ion binding]; metal-binding site
863767001699	dimer interface [polypeptide binding]; other site
863767001700	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
863767001701	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
863767001702	metal binding site [ion binding]; metal-binding site
863767001703	putative dimer interface [polypeptide binding]; other site
863767001704	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
863767001705	Beta-lactamase; Region: Beta-lactamase; pfam00144
863767001706	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
863767001707	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
863767001708	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
863767001709	intersubunit interface [polypeptide binding]; other site
863767001710	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
863767001711	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
863767001712	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
863767001713	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
863767001714	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
863767001715	Glucitol operon activator protein (GutM); Region: GutM; cl01890
863767001716	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
863767001717	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
863767001718	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
863767001719	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
863767001720	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
863767001721	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767001722	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
863767001723	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001724	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001725	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001726	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767001727	WxL domain surface cell wall-binding; Region: WxL; pfam13731
863767001728	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
863767001729	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
863767001730	FOG: CBS domain [General function prediction only]; Region: COG0517
863767001731	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
863767001732	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
863767001733	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
863767001734	dimer interface [polypeptide binding]; other site
863767001735	active site
863767001736	metal binding site [ion binding]; metal-binding site
863767001737	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
863767001738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767001739	putative substrate translocation pore; other site
863767001740	POT family; Region: PTR2; pfam00854
863767001741	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
863767001742	catalytic core [active]
863767001743	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
863767001744	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
863767001745	catalytic core [active]
863767001746	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
863767001747	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
863767001748	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
863767001749	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
863767001750	Cl binding site [ion binding]; other site
863767001751	oligomer interface [polypeptide binding]; other site
863767001752	glutamate dehydrogenase; Provisional; Region: PRK09414
863767001753	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
863767001754	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
863767001755	NAD(P) binding site [chemical binding]; other site
863767001756	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
863767001757	metal binding site [ion binding]; metal-binding site
863767001758	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
863767001759	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
863767001760	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
863767001761	substrate binding site [chemical binding]; other site
863767001762	glutamase interaction surface [polypeptide binding]; other site
863767001763	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
863767001764	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
863767001765	catalytic residues [active]
863767001766	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
863767001767	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
863767001768	putative active site [active]
863767001769	oxyanion strand; other site
863767001770	catalytic triad [active]
863767001771	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
863767001772	putative active site pocket [active]
863767001773	4-fold oligomerization interface [polypeptide binding]; other site
863767001774	metal binding residues [ion binding]; metal-binding site
863767001775	3-fold/trimer interface [polypeptide binding]; other site
863767001776	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
863767001777	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
863767001778	NAD binding site [chemical binding]; other site
863767001779	dimerization interface [polypeptide binding]; other site
863767001780	product binding site; other site
863767001781	substrate binding site [chemical binding]; other site
863767001782	zinc binding site [ion binding]; other site
863767001783	catalytic residues [active]
863767001784	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
863767001785	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
863767001786	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
863767001787	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
863767001788	dimer interface [polypeptide binding]; other site
863767001789	motif 1; other site
863767001790	active site
863767001791	motif 2; other site
863767001792	motif 3; other site
863767001793	histidinol-phosphatase; Reviewed; Region: PRK08123
863767001794	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
863767001795	active site
863767001796	dimer interface [polypeptide binding]; other site
863767001797	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
863767001798	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
863767001799	DNA binding site [nucleotide binding]
863767001800	active site
863767001801	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
863767001802	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
863767001803	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
863767001804	beta-galactosidase; Region: BGL; TIGR03356
863767001805	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
863767001806	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767001807	DNA-binding site [nucleotide binding]; DNA binding site
863767001808	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
863767001809	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001810	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767001811	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
863767001812	Uncharacterized conserved protein [Function unknown]; Region: COG2966
863767001813	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
863767001814	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
863767001815	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
863767001816	Predicted esterase [General function prediction only]; Region: COG0400
863767001817	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
863767001818	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
863767001819	putative RNA binding site [nucleotide binding]; other site
863767001820	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767001821	S-adenosylmethionine binding site [chemical binding]; other site
863767001822	invasion associated secreted endopeptidase; Provisional; Region: PRK13914
863767001823	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
863767001824	Bacterial SH3 domain; Region: SH3_3; pfam08239
863767001825	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
863767001826	NlpC/P60 family; Region: NLPC_P60; pfam00877
863767001827	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
863767001828	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
863767001829	ATP binding site [chemical binding]; other site
863767001830	putative Mg++ binding site [ion binding]; other site
863767001831	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
863767001832	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
863767001833	nucleotide binding region [chemical binding]; other site
863767001834	ATP-binding site [chemical binding]; other site
863767001835	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
863767001836	Domain of unknown function DUF20; Region: UPF0118; pfam01594
863767001837	WxL domain surface cell wall-binding; Region: WxL; pfam13731
863767001838	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
863767001839	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
863767001840	UreD urease accessory protein; Region: UreD; cl00530
863767001841	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
863767001842	DNA photolyase; Region: DNA_photolyase; pfam00875
863767001843	Predicted membrane protein [Function unknown]; Region: COG4852
863767001844	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
863767001845	DAK2 domain; Region: Dak2; pfam02734
863767001846	EDD domain protein, DegV family; Region: DegV; TIGR00762
863767001847	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
863767001848	Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752
863767001849	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
863767001850	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
863767001851	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
863767001852	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
863767001853	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
863767001854	homodimer interface [polypeptide binding]; other site
863767001855	substrate-cofactor binding pocket; other site
863767001856	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767001857	catalytic residue [active]
863767001858	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
863767001859	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767001860	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
863767001861	ligand binding site [chemical binding]; other site
863767001862	flexible hinge region; other site
863767001863	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
863767001864	BioY family; Region: BioY; pfam02632
863767001865	Predicted transcriptional regulators [Transcription]; Region: COG1695
863767001866	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
863767001867	Predicted membrane protein [Function unknown]; Region: COG4709
863767001868	Uncharacterized conserved protein [Function unknown]; Region: COG3595
863767001869	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
863767001870	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
863767001871	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
863767001872	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
863767001873	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767001874	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
863767001875	Coenzyme A binding pocket [chemical binding]; other site
863767001876	Tic20-like protein; Region: Tic20; pfam09685
863767001877	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
863767001878	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
863767001879	Transcriptional regulators [Transcription]; Region: MarR; COG1846
863767001880	MarR family; Region: MarR_2; pfam12802
863767001881	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
863767001882	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
863767001883	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767001884	Walker A/P-loop; other site
863767001885	ATP binding site [chemical binding]; other site
863767001886	Q-loop/lid; other site
863767001887	ABC transporter signature motif; other site
863767001888	Walker B; other site
863767001889	D-loop; other site
863767001890	H-loop/switch region; other site
863767001891	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
863767001892	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
863767001893	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
863767001894	Walker A/P-loop; other site
863767001895	ATP binding site [chemical binding]; other site
863767001896	Q-loop/lid; other site
863767001897	ABC transporter signature motif; other site
863767001898	Walker B; other site
863767001899	D-loop; other site
863767001900	H-loop/switch region; other site
863767001901	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
863767001902	active site residue [active]
863767001903	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767001904	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
863767001905	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
863767001906	Transcriptional regulators [Transcription]; Region: MarR; COG1846
863767001907	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
863767001908	putative DNA binding site [nucleotide binding]; other site
863767001909	putative Zn2+ binding site [ion binding]; other site
863767001910	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
863767001911	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
863767001912	putative NAD(P) binding site [chemical binding]; other site
863767001913	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
863767001914	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
863767001915	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
863767001916	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
863767001917	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
863767001918	putative active site [active]
863767001919	catalytic site [active]
863767001920	putative metal binding site [ion binding]; other site
863767001921	Catalytic domain of Protein Kinases; Region: PKc; cd00180
863767001922	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
863767001923	active site
863767001924	ATP binding site [chemical binding]; other site
863767001925	substrate binding site [chemical binding]; other site
863767001926	activation loop (A-loop); other site
863767001927	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
863767001928	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
863767001929	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
863767001930	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
863767001931	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767001932	Coenzyme A binding pocket [chemical binding]; other site
863767001933	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
863767001934	active site
863767001935	catalytic triad [active]
863767001936	oxyanion hole [active]
863767001937	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
863767001938	domain interaction interfaces [polypeptide binding]; other site
863767001939	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
863767001940	domain interaction interfaces [polypeptide binding]; other site
863767001941	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
863767001942	domain interaction interfaces [polypeptide binding]; other site
863767001943	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
863767001944	domain interaction interfaces [polypeptide binding]; other site
863767001945	Isochorismatase family; Region: Isochorismatase; pfam00857
863767001946	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
863767001947	catalytic triad [active]
863767001948	conserved cis-peptide bond; other site
863767001949	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
863767001950	PRD domain; Region: PRD; pfam00874
863767001951	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
863767001952	active site
863767001953	P-loop; other site
863767001954	phosphorylation site [posttranslational modification]
863767001955	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767001956	active site
863767001957	phosphorylation site [posttranslational modification]
863767001958	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767001959	active site
863767001960	phosphorylation site [posttranslational modification]
863767001961	putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478
863767001962	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
863767001963	active site
863767001964	P-loop; other site
863767001965	phosphorylation site [posttranslational modification]
863767001966	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211
863767001967	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
863767001968	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767001969	motif II; other site
863767001970	Predicted transcriptional regulator [Transcription]; Region: COG1959
863767001971	Transcriptional regulator; Region: Rrf2; pfam02082
863767001972	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767001973	S-adenosylmethionine binding site [chemical binding]; other site
863767001974	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
863767001975	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
863767001976	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
863767001977	Int/Topo IB signature motif; other site
863767001978	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
863767001979	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767001980	non-specific DNA binding site [nucleotide binding]; other site
863767001981	salt bridge; other site
863767001982	sequence-specific DNA binding site [nucleotide binding]; other site
863767001983	Domain of unknown function (DUF4121); Region: DUF4121; pfam13497
863767001984	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
863767001985	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767001986	non-specific DNA binding site [nucleotide binding]; other site
863767001987	salt bridge; other site
863767001988	sequence-specific DNA binding site [nucleotide binding]; other site
863767001989	Domain of unknown function (DUF771); Region: DUF771; pfam05595
863767001990	Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524
863767001991	Methyltransferase domain; Region: Methyltransf_25; pfam13649
863767001992	S-adenosylmethionine binding site [chemical binding]; other site
863767001993	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
863767001994	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
863767001995	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
863767001996	dimer interface [polypeptide binding]; other site
863767001997	ssDNA binding site [nucleotide binding]; other site
863767001998	tetramer (dimer of dimers) interface [polypeptide binding]; other site
863767001999	positive control sigma-like factor; Validated; Region: PRK06930
863767002000	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
863767002001	DNA binding residues [nucleotide binding]
863767002002	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
863767002003	active site
863767002004	DNA binding site [nucleotide binding]
863767002005	Int/Topo IB signature motif; other site
863767002006	Phage terminase, small subunit; Region: Terminase_4; pfam05119
863767002007	Phage Terminase; Region: Terminase_1; pfam03354
863767002008	Phage-related protein [Function unknown]; Region: COG4695; cl01923
863767002009	Phage portal protein; Region: Phage_portal; pfam04860
863767002010	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
863767002011	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
863767002012	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
863767002013	Phage capsid family; Region: Phage_capsid; pfam05065
863767002014	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
863767002015	oligomerization interface [polypeptide binding]; other site
863767002016	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
863767002017	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
863767002018	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
863767002019	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
863767002020	Phage tail protein; Region: Sipho_tail; cl17486
863767002021	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
863767002022	Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669
863767002023	Phage holin; Region: Phage_holin_5; pfam06946
863767002024	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
863767002025	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
863767002026	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
863767002027	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
863767002028	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
863767002029	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
863767002030	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
863767002031	active site
863767002032	catalytic tetrad [active]
863767002033	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
863767002034	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
863767002035	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767002036	motif II; other site
863767002037	Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176
863767002038	catalytic residue [active]
863767002039	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
863767002040	Sulfatase; Region: Sulfatase; pfam00884
863767002041	amino acid transporter; Region: 2A0306; TIGR00909
863767002042	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
863767002043	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
863767002044	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
863767002045	putative metal binding site [ion binding]; other site
863767002046	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
863767002047	active site
863767002048	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
863767002049	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
863767002050	Cl binding site [ion binding]; other site
863767002051	oligomer interface [polypeptide binding]; other site
863767002052	Transcriptional regulators [Transcription]; Region: GntR; COG1802
863767002053	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767002054	DNA-binding site [nucleotide binding]; DNA binding site
863767002055	Predicted membrane protein [Function unknown]; Region: COG1511
863767002056	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
863767002057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767002058	Transcriptional regulators [Transcription]; Region: GntR; COG1802
863767002059	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767002060	DNA-binding site [nucleotide binding]; DNA binding site
863767002061	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
863767002062	Predicted integral membrane protein [Function unknown]; Region: COG5523
863767002063	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
863767002064	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
863767002065	active site
863767002066	metal binding site [ion binding]; metal-binding site
863767002067	Predicted membrane protein [Function unknown]; Region: COG2322
863767002068	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
863767002069	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
863767002070	minor groove reading motif; other site
863767002071	helix-hairpin-helix signature motif; other site
863767002072	substrate binding pocket [chemical binding]; other site
863767002073	active site
863767002074	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767002075	non-specific DNA binding site [nucleotide binding]; other site
863767002076	salt bridge; other site
863767002077	sequence-specific DNA binding site [nucleotide binding]; other site
863767002078	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
863767002079	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
863767002080	Transposase; Region: HTH_Tnp_1; cl17663
863767002081	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767002082	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767002083	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767002084	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
863767002085	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
863767002086	dimer interface [polypeptide binding]; other site
863767002087	substrate binding site [chemical binding]; other site
863767002088	ATP binding site [chemical binding]; other site
863767002089	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
863767002090	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767002091	active site
863767002092	motif I; other site
863767002093	motif II; other site
863767002094	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767002095	maltose O-acetyltransferase; Provisional; Region: PRK10092
863767002096	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
863767002097	active site
863767002098	substrate binding site [chemical binding]; other site
863767002099	trimer interface [polypeptide binding]; other site
863767002100	CoA binding site [chemical binding]; other site
863767002101	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
863767002102	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
863767002103	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
863767002104	Walker A/P-loop; other site
863767002105	ATP binding site [chemical binding]; other site
863767002106	Q-loop/lid; other site
863767002107	ABC transporter signature motif; other site
863767002108	Walker B; other site
863767002109	D-loop; other site
863767002110	H-loop/switch region; other site
863767002111	inner membrane transport permease; Provisional; Region: PRK15066
863767002112	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
863767002113	oxidoreductase; Provisional; Region: PRK07985
863767002114	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
863767002115	NAD(P) binding site [chemical binding]; other site
863767002116	active site
863767002117	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
863767002118	Predicted membrane protein [Function unknown]; Region: COG3152
863767002119	DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181
863767002120	Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338
863767002121	Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987
863767002122	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
863767002123	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
863767002124	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
863767002125	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298
863767002126	FHIPEP family; Region: FHIPEP; pfam00771
863767002127	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726
863767002128	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
863767002129	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819
863767002130	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
863767002131	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
863767002132	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
863767002133	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
863767002134	Protein of unknown function (DUF3964); Region: DUF3964; pfam13107
863767002135	flagellar motor protein MotA; Validated; Region: PRK08124
863767002136	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
863767002137	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
863767002138	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
863767002139	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
863767002140	ligand binding site [chemical binding]; other site
863767002141	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
863767002142	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
863767002143	putative metal binding site; other site
863767002144	TPR repeat; Region: TPR_11; pfam13414
863767002145	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
863767002146	binding surface
863767002147	TPR motif; other site
863767002148	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
863767002149	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
863767002150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767002151	active site
863767002152	phosphorylation site [posttranslational modification]
863767002153	intermolecular recognition site; other site
863767002154	dimerization interface [polypeptide binding]; other site
863767002155	flagellin; Provisional; Region: PRK12805
863767002156	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
863767002157	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
863767002158	Response regulator receiver domain; Region: Response_reg; pfam00072
863767002159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767002160	active site
863767002161	phosphorylation site [posttranslational modification]
863767002162	intermolecular recognition site; other site
863767002163	dimerization interface [polypeptide binding]; other site
863767002164	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
863767002165	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
863767002166	putative binding surface; other site
863767002167	active site
863767002168	P2 response regulator binding domain; Region: P2; pfam07194
863767002169	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
863767002170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767002171	ATP binding site [chemical binding]; other site
863767002172	Mg2+ binding site [ion binding]; other site
863767002173	G-X-G motif; other site
863767002174	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
863767002175	flagellar motor switch protein; Validated; Region: PRK06788
863767002176	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
863767002177	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911
863767002178	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
863767002179	Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749
863767002180	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
863767002181	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
863767002182	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
863767002183	flagellar motor switch protein; Validated; Region: PRK06789
863767002184	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
863767002185	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
863767002186	flagellar motor switch protein; Reviewed; Region: PRK06782
863767002187	CheC-like family; Region: CheC; pfam04509
863767002188	CheC-like family; Region: CheC; pfam04509
863767002189	Chemotaxis phosphatase CheX; Region: CheX; cl15816
863767002190	CheC-like family; Region: CheC; pfam04509
863767002191	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
863767002192	Protein of unknown function (DUF327); Region: DUF327; pfam03885
863767002193	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799
863767002194	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
863767002195	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073
863767002196	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
863767002197	flagellar capping protein; Validated; Region: fliD; PRK06798
863767002198	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
863767002199	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
863767002200	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
863767002201	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797
863767002202	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558
863767002203	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
863767002204	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699
863767002205	Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766
863767002206	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
863767002207	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
863767002208	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
863767002209	FliG C-terminal domain; Region: FliG_C; pfam01706
863767002210	flagellar assembly protein H; Validated; Region: fliH; PRK06800
863767002211	Flagellar assembly protein FliH; Region: FliH; pfam02108
863767002212	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793
863767002213	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
863767002214	Walker A motif; other site
863767002215	ATP binding site [chemical binding]; other site
863767002216	Walker B motif; other site
863767002217	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
863767002218	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
863767002219	N-acetyl-D-glucosamine binding site [chemical binding]; other site
863767002220	catalytic residue [active]
863767002221	Predicted transcriptional regulators [Transcription]; Region: COG1695
863767002222	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
863767002223	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
863767002224	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
863767002225	pyruvate oxidase; Provisional; Region: PRK08611
863767002226	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
863767002227	PYR/PP interface [polypeptide binding]; other site
863767002228	dimer interface [polypeptide binding]; other site
863767002229	tetramer interface [polypeptide binding]; other site
863767002230	TPP binding site [chemical binding]; other site
863767002231	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
863767002232	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
863767002233	TPP-binding site [chemical binding]; other site
863767002234	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
863767002235	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
863767002236	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
863767002237	dimerization interface [polypeptide binding]; other site
863767002238	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
863767002239	dimer interface [polypeptide binding]; other site
863767002240	putative CheW interface [polypeptide binding]; other site
863767002241	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
863767002242	putative active site [active]
863767002243	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
863767002244	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
863767002245	glutaminase active site [active]
863767002246	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
863767002247	dimer interface [polypeptide binding]; other site
863767002248	active site
863767002249	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
863767002250	dimer interface [polypeptide binding]; other site
863767002251	active site
863767002252	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
863767002253	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
863767002254	active site
863767002255	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
863767002256	GIY-YIG motif/motif A; other site
863767002257	Leucine rich repeat; Region: LRR_8; pfam13855
863767002258	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767002259	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767002260	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767002261	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
863767002262	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767002263	non-specific DNA binding site [nucleotide binding]; other site
863767002264	salt bridge; other site
863767002265	sequence-specific DNA binding site [nucleotide binding]; other site
863767002266	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767002267	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
863767002268	ligand binding site [chemical binding]; other site
863767002269	flexible hinge region; other site
863767002270	Predicted transcriptional regulators [Transcription]; Region: COG1725
863767002271	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767002272	DNA-binding site [nucleotide binding]; DNA binding site
863767002273	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
863767002274	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767002275	Walker A/P-loop; other site
863767002276	ATP binding site [chemical binding]; other site
863767002277	Q-loop/lid; other site
863767002278	ABC transporter signature motif; other site
863767002279	Walker B; other site
863767002280	D-loop; other site
863767002281	H-loop/switch region; other site
863767002282	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
863767002283	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
863767002284	Walker A/P-loop; other site
863767002285	ATP binding site [chemical binding]; other site
863767002286	Q-loop/lid; other site
863767002287	ABC transporter signature motif; other site
863767002288	Walker B; other site
863767002289	D-loop; other site
863767002290	H-loop/switch region; other site
863767002291	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
863767002292	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
863767002293	FtsX-like permease family; Region: FtsX; pfam02687
863767002294	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
863767002295	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767002296	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
863767002297	ligand binding site [chemical binding]; other site
863767002298	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
863767002299	non-specific DNA interactions [nucleotide binding]; other site
863767002300	DNA binding site [nucleotide binding]
863767002301	sequence specific DNA binding site [nucleotide binding]; other site
863767002302	putative cAMP binding site [chemical binding]; other site
863767002303	SnoaL-like domain; Region: SnoaL_4; pfam13577
863767002304	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
863767002305	active site
863767002306	catalytic triad [active]
863767002307	oxyanion hole [active]
863767002308	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767002309	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
863767002310	Walker A/P-loop; other site
863767002311	ATP binding site [chemical binding]; other site
863767002312	Q-loop/lid; other site
863767002313	ABC transporter signature motif; other site
863767002314	Walker B; other site
863767002315	D-loop; other site
863767002316	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
863767002317	H-loop/switch region; other site
863767002318	active site
863767002319	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
863767002320	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
863767002321	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
863767002322	Zn binding site [ion binding]; other site
863767002323	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
863767002324	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
863767002325	Zn binding site [ion binding]; other site
863767002326	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
863767002327	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
863767002328	Zn binding site [ion binding]; other site
863767002329	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
863767002330	Zn binding site [ion binding]; other site
863767002331	Predicted esterase [General function prediction only]; Region: COG0400
863767002332	putative hydrolase; Provisional; Region: PRK11460
863767002333	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
863767002334	GTPases [General function prediction only]; Region: HflX; COG2262
863767002335	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
863767002336	HflX GTPase family; Region: HflX; cd01878
863767002337	G1 box; other site
863767002338	GTP/Mg2+ binding site [chemical binding]; other site
863767002339	Switch I region; other site
863767002340	G2 box; other site
863767002341	G3 box; other site
863767002342	Switch II region; other site
863767002343	G4 box; other site
863767002344	G5 box; other site
863767002345	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
863767002346	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
863767002347	putative active site [active]
863767002348	putative metal binding site [ion binding]; other site
863767002349	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
863767002350	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
863767002351	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
863767002352	Uncharacterized conserved protein [Function unknown]; Region: COG3538
863767002353	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
863767002354	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
863767002355	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767002356	putative PBP binding loops; other site
863767002357	ABC-ATPase subunit interface; other site
863767002358	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
863767002359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767002360	dimer interface [polypeptide binding]; other site
863767002361	conserved gate region; other site
863767002362	putative PBP binding loops; other site
863767002363	ABC-ATPase subunit interface; other site
863767002364	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
863767002365	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
863767002366	Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833
863767002367	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767002368	DNA-binding site [nucleotide binding]; DNA binding site
863767002369	Transcriptional regulators [Transcription]; Region: PurR; COG1609
863767002370	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
863767002371	ligand binding site [chemical binding]; other site
863767002372	dimerization interface [polypeptide binding]; other site
863767002373	Transcriptional regulators [Transcription]; Region: GntR; COG1802
863767002374	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767002375	DNA-binding site [nucleotide binding]; DNA binding site
863767002376	Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289
863767002377	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
863767002378	putative NADP binding site [chemical binding]; other site
863767002379	putative dimer interface [polypeptide binding]; other site
863767002380	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
863767002381	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
863767002382	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
863767002383	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
863767002384	nucleotide binding site [chemical binding]; other site
863767002385	Predicted membrane protein [Function unknown]; Region: COG4811
863767002386	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
863767002387	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
863767002388	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
863767002389	active site
863767002390	phosphorylation site [posttranslational modification]
863767002391	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
863767002392	active pocket/dimerization site; other site
863767002393	active site
863767002394	phosphorylation site [posttranslational modification]
863767002395	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
863767002396	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767002397	Walker A motif; other site
863767002398	ATP binding site [chemical binding]; other site
863767002399	Walker B motif; other site
863767002400	arginine finger; other site
863767002401	Transcriptional antiterminator [Transcription]; Region: COG3933
863767002402	PRD domain; Region: PRD; pfam00874
863767002403	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
863767002404	active pocket/dimerization site; other site
863767002405	active site
863767002406	phosphorylation site [posttranslational modification]
863767002407	PRD domain; Region: PRD; pfam00874
863767002408	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
863767002409	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
863767002410	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
863767002411	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
863767002412	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
863767002413	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
863767002414	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
863767002415	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
863767002416	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
863767002417	Leucine rich repeat; Region: LRR_8; pfam13855
863767002418	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767002419	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767002420	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767002421	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767002422	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767002423	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
863767002424	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
863767002425	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
863767002426	putative deacylase active site [active]
863767002427	Predicted amidohydrolase [General function prediction only]; Region: COG0388
863767002428	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
863767002429	active site
863767002430	catalytic triad [active]
863767002431	dimer interface [polypeptide binding]; other site
863767002432	Protein of unknown function (DUF554); Region: DUF554; pfam04474
863767002433	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
863767002434	NADH(P)-binding; Region: NAD_binding_10; pfam13460
863767002435	NAD binding site [chemical binding]; other site
863767002436	substrate binding site [chemical binding]; other site
863767002437	putative active site [active]
863767002438	Predicted permeases [General function prediction only]; Region: RarD; COG2962
863767002439	EamA-like transporter family; Region: EamA; pfam00892
863767002440	Uncharacterized conserved protein [Function unknown]; Region: COG2353
863767002441	Transcriptional regulators [Transcription]; Region: MarR; COG1846
863767002442	MarR family; Region: MarR_2; pfam12802
863767002443	lysine transporter; Provisional; Region: PRK10836
863767002444	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
863767002445	PAS domain; Region: PAS_9; pfam13426
863767002446	putative active site [active]
863767002447	heme pocket [chemical binding]; other site
863767002448	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
863767002449	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
863767002450	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
863767002451	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
863767002452	synthetase active site [active]
863767002453	NTP binding site [chemical binding]; other site
863767002454	metal binding site [ion binding]; metal-binding site
863767002455	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
863767002456	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
863767002457	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
863767002458	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767002459	non-specific DNA binding site [nucleotide binding]; other site
863767002460	salt bridge; other site
863767002461	sequence-specific DNA binding site [nucleotide binding]; other site
863767002462	Cupin domain; Region: Cupin_2; pfam07883
863767002463	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
863767002464	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
863767002465	Walker A/P-loop; other site
863767002466	ATP binding site [chemical binding]; other site
863767002467	Q-loop/lid; other site
863767002468	ABC transporter signature motif; other site
863767002469	Walker B; other site
863767002470	D-loop; other site
863767002471	H-loop/switch region; other site
863767002472	TOBE domain; Region: TOBE_2; pfam08402
863767002473	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
863767002474	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767002475	putative PBP binding loops; other site
863767002476	ABC-ATPase subunit interface; other site
863767002477	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
863767002478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767002479	dimer interface [polypeptide binding]; other site
863767002480	conserved gate region; other site
863767002481	putative PBP binding loops; other site
863767002482	ABC-ATPase subunit interface; other site
863767002483	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
863767002484	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
863767002485	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
863767002486	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
863767002487	active site
863767002488	zinc binding site [ion binding]; other site
863767002489	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
863767002490	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
863767002491	Zn2+ binding site [ion binding]; other site
863767002492	Mg2+ binding site [ion binding]; other site
863767002493	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
863767002494	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
863767002495	nucleotide binding site [chemical binding]; other site
863767002496	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
863767002497	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
863767002498	FMN binding site [chemical binding]; other site
863767002499	substrate binding site [chemical binding]; other site
863767002500	putative catalytic residue [active]
863767002501	Transcriptional regulators [Transcription]; Region: MarR; COG1846
863767002502	MarR family; Region: MarR_2; pfam12802
863767002503	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
863767002504	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767002505	Coenzyme A binding pocket [chemical binding]; other site
863767002506	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
863767002507	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
863767002508	dimer interface [polypeptide binding]; other site
863767002509	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
863767002510	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
863767002511	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
863767002512	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
863767002513	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
863767002514	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767002515	motif II; other site
863767002516	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
863767002517	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
863767002518	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767002519	Coenzyme A binding pocket [chemical binding]; other site
863767002520	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
863767002521	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
863767002522	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
863767002523	DNA binding residues [nucleotide binding]
863767002524	putative dimer interface [polypeptide binding]; other site
863767002525	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
863767002526	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
863767002527	active site
863767002528	catalytic tetrad [active]
863767002529	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
863767002530	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
863767002531	homodimer interface [polypeptide binding]; other site
863767002532	catalytic residues [active]
863767002533	NAD binding site [chemical binding]; other site
863767002534	substrate binding pocket [chemical binding]; other site
863767002535	flexible flap; other site
863767002536	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
863767002537	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
863767002538	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
863767002539	PhoU domain; Region: PhoU; pfam01895
863767002540	PhoU domain; Region: PhoU; pfam01895
863767002541	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
863767002542	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
863767002543	dimer interface [polypeptide binding]; other site
863767002544	PYR/PP interface [polypeptide binding]; other site
863767002545	TPP binding site [chemical binding]; other site
863767002546	substrate binding site [chemical binding]; other site
863767002547	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
863767002548	Domain of unknown function; Region: EKR; smart00890
863767002549	4Fe-4S binding domain; Region: Fer4_6; pfam12837
863767002550	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
863767002551	TPP-binding site [chemical binding]; other site
863767002552	dimer interface [polypeptide binding]; other site
863767002553	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
863767002554	Predicted permeases [General function prediction only]; Region: COG0679
863767002555	Helix-turn-helix domain; Region: HTH_28; pfam13518
863767002556	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767002557	non-specific DNA binding site [nucleotide binding]; other site
863767002558	salt bridge; other site
863767002559	sequence-specific DNA binding site [nucleotide binding]; other site
863767002560	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
863767002561	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767002562	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767002563	Predicted membrane protein [Function unknown]; Region: COG3223
863767002564	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
863767002565	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
863767002566	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
863767002567	Walker A/P-loop; other site
863767002568	ATP binding site [chemical binding]; other site
863767002569	Q-loop/lid; other site
863767002570	ABC transporter signature motif; other site
863767002571	Walker B; other site
863767002572	D-loop; other site
863767002573	H-loop/switch region; other site
863767002574	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
863767002575	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767002576	putative substrate translocation pore; other site
863767002577	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767002578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767002579	Major Facilitator Superfamily; Region: MFS_1; pfam07690
863767002580	putative substrate translocation pore; other site
863767002581	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
863767002582	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
863767002583	putative DNA binding site [nucleotide binding]; other site
863767002584	putative Zn2+ binding site [ion binding]; other site
863767002585	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
863767002586	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
863767002587	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
863767002588	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
863767002589	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767002590	motif II; other site
863767002591	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
863767002592	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767002593	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767002594	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767002595	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767002596	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767002597	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767002598	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767002599	Predicted membrane protein [Function unknown]; Region: COG3326
863767002600	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
863767002601	homotrimer interaction site [polypeptide binding]; other site
863767002602	putative active site [active]
863767002603	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
863767002604	substrate binding site [chemical binding]; other site
863767002605	zinc-binding site [ion binding]; other site
863767002606	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
863767002607	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
863767002608	GIY-YIG motif/motif A; other site
863767002609	active site
863767002610	catalytic site [active]
863767002611	putative DNA binding site [nucleotide binding]; other site
863767002612	metal binding site [ion binding]; metal-binding site
863767002613	UvrB/uvrC motif; Region: UVR; pfam02151
863767002614	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
863767002615	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
863767002616	substrate binding pocket [chemical binding]; other site
863767002617	membrane-bound complex binding site; other site
863767002618	hinge residues; other site
863767002619	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
863767002620	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767002621	dimer interface [polypeptide binding]; other site
863767002622	conserved gate region; other site
863767002623	putative PBP binding loops; other site
863767002624	ABC-ATPase subunit interface; other site
863767002625	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
863767002626	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
863767002627	Walker A/P-loop; other site
863767002628	ATP binding site [chemical binding]; other site
863767002629	Q-loop/lid; other site
863767002630	ABC transporter signature motif; other site
863767002631	Walker B; other site
863767002632	D-loop; other site
863767002633	H-loop/switch region; other site
863767002634	amidase; Provisional; Region: PRK11910
863767002635	Amidase; Region: Amidase; cl11426
863767002636	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
863767002637	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
863767002638	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
863767002639	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
863767002640	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
863767002641	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
863767002642	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
863767002643	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
863767002644	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
863767002645	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
863767002646	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
863767002647	Esterase/lipase [General function prediction only]; Region: COG1647
863767002648	Transcriptional regulators [Transcription]; Region: PurR; COG1609
863767002649	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
863767002650	DNA binding site [nucleotide binding]
863767002651	domain linker motif; other site
863767002652	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277
863767002653	putative dimerization interface [polypeptide binding]; other site
863767002654	putative ligand binding site [chemical binding]; other site
863767002655	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
863767002656	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
863767002657	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
863767002658	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767002659	dimer interface [polypeptide binding]; other site
863767002660	conserved gate region; other site
863767002661	putative PBP binding loops; other site
863767002662	ABC-ATPase subunit interface; other site
863767002663	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
863767002664	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767002665	dimer interface [polypeptide binding]; other site
863767002666	conserved gate region; other site
863767002667	ABC-ATPase subunit interface; other site
863767002668	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
863767002669	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
863767002670	Ca binding site [ion binding]; other site
863767002671	active site
863767002672	catalytic site [active]
863767002673	Protein of unknown function (DUF1861); Region: DUF1861; pfam08950
863767002674	Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152
863767002675	active site
863767002676	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
863767002677	active site
863767002678	substrate binding site [chemical binding]; other site
863767002679	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
863767002680	metal binding site [ion binding]; metal-binding site
863767002681	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
863767002682	DEAD-like helicases superfamily; Region: DEXDc; smart00487
863767002683	ATP binding site [chemical binding]; other site
863767002684	Mg++ binding site [ion binding]; other site
863767002685	motif III; other site
863767002686	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
863767002687	nucleotide binding region [chemical binding]; other site
863767002688	ATP-binding site [chemical binding]; other site
863767002689	QueT transporter; Region: QueT; cl01932
863767002690	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
863767002691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367
863767002692	Predicted transcriptional regulators [Transcription]; Region: COG1733
863767002693	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
863767002694	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
863767002695	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767002696	putative substrate translocation pore; other site
863767002697	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
863767002698	PRD domain; Region: PRD; pfam00874
863767002699	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
863767002700	active site
863767002701	P-loop; other site
863767002702	phosphorylation site [posttranslational modification]
863767002703	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767002704	active site
863767002705	phosphorylation site [posttranslational modification]
863767002706	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
863767002707	methionine cluster; other site
863767002708	active site
863767002709	phosphorylation site [posttranslational modification]
863767002710	metal binding site [ion binding]; metal-binding site
863767002711	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
863767002712	active site
863767002713	P-loop; other site
863767002714	phosphorylation site [posttranslational modification]
863767002715	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
863767002716	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
863767002717	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
863767002718	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
863767002719	active site
863767002720	trimer interface [polypeptide binding]; other site
863767002721	allosteric site; other site
863767002722	active site lid [active]
863767002723	hexamer (dimer of trimers) interface [polypeptide binding]; other site
863767002724	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
863767002725	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
863767002726	active site
863767002727	catalytic tetrad [active]
863767002728	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
863767002729	Collagen binding domain; Region: Collagen_bind; pfam05737
863767002730	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
863767002731	Uncharacterized conserved protein [Function unknown]; Region: COG3402
863767002732	Predicted membrane protein [Function unknown]; Region: COG3428
863767002733	Bacterial PH domain; Region: DUF304; pfam03703
863767002734	Bacterial PH domain; Region: DUF304; pfam03703
863767002735	Predicted membrane protein [Function unknown]; Region: COG3428
863767002736	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
863767002737	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
863767002738	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
863767002739	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
863767002740	active site
863767002741	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
863767002742	dimer interface [polypeptide binding]; other site
863767002743	substrate binding site [chemical binding]; other site
863767002744	catalytic residues [active]
863767002745	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
863767002746	PemK-like protein; Region: PemK; pfam02452
863767002747	Rsbr N terminal; Region: Rsbr_N; pfam08678
863767002748	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
863767002749	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
863767002750	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
863767002751	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
863767002752	ATP binding site [chemical binding]; other site
863767002753	Mg2+ binding site [ion binding]; other site
863767002754	G-X-G motif; other site
863767002755	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
863767002756	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
863767002757	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
863767002758	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
863767002759	anti sigma factor interaction site; other site
863767002760	regulatory phosphorylation site [posttranslational modification]; other site
863767002761	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
863767002762	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767002763	ATP binding site [chemical binding]; other site
863767002764	Mg2+ binding site [ion binding]; other site
863767002765	G-X-G motif; other site
863767002766	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
863767002767	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
863767002768	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
863767002769	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
863767002770	DNA binding residues [nucleotide binding]
863767002771	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
863767002772	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
863767002773	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
863767002774	Sulfate transporter family; Region: Sulfate_transp; pfam00916
863767002775	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
863767002776	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
863767002777	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
863767002778	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
863767002779	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
863767002780	RNA binding site [nucleotide binding]; other site
863767002781	hypothetical protein; Provisional; Region: PRK04351
863767002782	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
863767002783	Domain of unknown function (DUF1768); Region: DUF1768; cl01271
863767002784	Domain of unknown function (DUF1768); Region: DUF1768; cl01271
863767002785	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
863767002786	Uncharacterized conserved protein [Function unknown]; Region: COG5646
863767002787	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
863767002788	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
863767002789	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
863767002790	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767002791	DNA-binding site [nucleotide binding]; DNA binding site
863767002792	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
863767002793	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
863767002794	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
863767002795	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
863767002796	glutathione reductase; Validated; Region: PRK06116
863767002797	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
863767002798	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
863767002799	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
863767002800	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
863767002801	catalytic core [active]
863767002802	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
863767002803	Domain of unknown function DUF20; Region: UPF0118; pfam01594
863767002804	Predicted transcriptional regulators [Transcription]; Region: COG1725
863767002805	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767002806	DNA-binding site [nucleotide binding]; DNA binding site
863767002807	Predicted membrane protein [General function prediction only]; Region: COG4194
863767002808	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
863767002809	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
863767002810	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
863767002811	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
863767002812	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
863767002813	tetramerization interface [polypeptide binding]; other site
863767002814	NAD(P) binding site [chemical binding]; other site
863767002815	catalytic residues [active]
863767002816	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
863767002817	active site
863767002818	P-loop; other site
863767002819	phosphorylation site [posttranslational modification]
863767002820	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
863767002821	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
863767002822	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
863767002823	methionine cluster; other site
863767002824	active site
863767002825	phosphorylation site [posttranslational modification]
863767002826	metal binding site [ion binding]; metal-binding site
863767002827	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
863767002828	beta-galactosidase; Region: BGL; TIGR03356
863767002829	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
863767002830	Mga helix-turn-helix domain; Region: Mga; pfam05043
863767002831	PRD domain; Region: PRD; pfam00874
863767002832	PRD domain; Region: PRD; pfam00874
863767002833	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767002834	active site
863767002835	phosphorylation site [posttranslational modification]
863767002836	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
863767002837	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
863767002838	ABC transporter; Region: ABC_tran_2; pfam12848
863767002839	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
863767002840	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
863767002841	Predicted permeases [General function prediction only]; Region: COG0701
863767002842	Predicted membrane protein [Function unknown]; Region: COG3689
863767002843	pantothenate kinase; Provisional; Region: PRK05439
863767002844	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
863767002845	ATP-binding site [chemical binding]; other site
863767002846	CoA-binding site [chemical binding]; other site
863767002847	Mg2+-binding site [ion binding]; other site
863767002848	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
863767002849	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
863767002850	Walker A/P-loop; other site
863767002851	ATP binding site [chemical binding]; other site
863767002852	Q-loop/lid; other site
863767002853	ABC transporter signature motif; other site
863767002854	Walker B; other site
863767002855	D-loop; other site
863767002856	H-loop/switch region; other site
863767002857	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
863767002858	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
863767002859	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
863767002860	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
863767002861	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
863767002862	Domain of unknown function (DUF373); Region: DUF373; cl12079
863767002863	Sulfatase; Region: Sulfatase; pfam00884
863767002864	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
863767002865	active site
863767002866	DNA binding site [nucleotide binding]
863767002867	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
863767002868	active site
863767002869	catalytic site [active]
863767002870	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
863767002871	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
863767002872	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
863767002873	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
863767002874	Uncharacterized conserved protein [Function unknown]; Region: COG0398
863767002875	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
863767002876	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
863767002877	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
863767002878	Ligand binding site; other site
863767002879	Putative Catalytic site; other site
863767002880	DXD motif; other site
863767002881	epoxyqueuosine reductase; Region: TIGR00276
863767002882	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
863767002883	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
863767002884	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
863767002885	dimer interface [polypeptide binding]; other site
863767002886	FMN binding site [chemical binding]; other site
863767002887	NADPH bind site [chemical binding]; other site
863767002888	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
863767002889	Low molecular weight phosphatase family; Region: LMWPc; cd00115
863767002890	active site
863767002891	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
863767002892	HSP90 family protein; Provisional; Region: PRK14083
863767002893	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767002894	ATP binding site [chemical binding]; other site
863767002895	Mg2+ binding site [ion binding]; other site
863767002896	G-X-G motif; other site
863767002897	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
863767002898	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
863767002899	dimerization interface [polypeptide binding]; other site
863767002900	DPS ferroxidase diiron center [ion binding]; other site
863767002901	ion pore; other site
863767002902	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
863767002903	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
863767002904	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
863767002905	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
863767002906	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
863767002907	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
863767002908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767002909	putative substrate translocation pore; other site
863767002910	Transcriptional regulators [Transcription]; Region: FadR; COG2186
863767002911	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767002912	DNA-binding site [nucleotide binding]; DNA binding site
863767002913	FCD domain; Region: FCD; pfam07729
863767002914	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
863767002915	Domain of unknown function DUF20; Region: UPF0118; pfam01594
863767002916	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
863767002917	PGAP1-like protein; Region: PGAP1; pfam07819
863767002918	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
863767002919	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
863767002920	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
863767002921	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
863767002922	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
863767002923	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
863767002924	active site
863767002925	dimer interface [polypeptide binding]; other site
863767002926	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
863767002927	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
863767002928	active site
863767002929	trimer interface [polypeptide binding]; other site
863767002930	allosteric site; other site
863767002931	active site lid [active]
863767002932	hexamer (dimer of trimers) interface [polypeptide binding]; other site
863767002933	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
863767002934	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767002935	DNA-binding site [nucleotide binding]; DNA binding site
863767002936	UTRA domain; Region: UTRA; pfam07702
863767002937	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
863767002938	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
863767002939	Mg++ binding site [ion binding]; other site
863767002940	putative catalytic motif [active]
863767002941	substrate binding site [chemical binding]; other site
863767002942	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
863767002943	Peptidase family U32; Region: Peptidase_U32; pfam01136
863767002944	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
863767002945	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
863767002946	Peptidase family U32; Region: Peptidase_U32; pfam01136
863767002947	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
863767002948	heat shock protein HtpX; Provisional; Region: PRK04897
863767002949	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
863767002950	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
863767002951	catalytic residues [active]
863767002952	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
863767002953	putative active site [active]
863767002954	putative metal binding residues [ion binding]; other site
863767002955	signature motif; other site
863767002956	putative triphosphate binding site [ion binding]; other site
863767002957	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
863767002958	TPR motif; other site
863767002959	binding surface
863767002960	Tetratrico peptide repeat; Region: TPR_5; pfam12688
863767002961	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
863767002962	synthetase active site [active]
863767002963	NTP binding site [chemical binding]; other site
863767002964	metal binding site [ion binding]; metal-binding site
863767002965	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
863767002966	ATP-NAD kinase; Region: NAD_kinase; pfam01513
863767002967	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
863767002968	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
863767002969	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
863767002970	active site
863767002971	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
863767002972	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
863767002973	NAD binding site [chemical binding]; other site
863767002974	homotetramer interface [polypeptide binding]; other site
863767002975	homodimer interface [polypeptide binding]; other site
863767002976	substrate binding site [chemical binding]; other site
863767002977	active site
863767002978	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
863767002979	DltD N-terminal region; Region: DltD_N; pfam04915
863767002980	DltD central region; Region: DltD_M; pfam04918
863767002981	DltD C-terminal region; Region: DltD_C; pfam04914
863767002982	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
863767002983	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
863767002984	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
863767002985	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
863767002986	acyl-activating enzyme (AAE) consensus motif; other site
863767002987	AMP binding site [chemical binding]; other site
863767002988	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
863767002989	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
863767002990	tetramer (dimer of dimers) interface [polypeptide binding]; other site
863767002991	active site
863767002992	dimer interface [polypeptide binding]; other site
863767002993	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767002994	Coenzyme A binding pocket [chemical binding]; other site
863767002995	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
863767002996	Putative esterase; Region: Esterase; pfam00756
863767002997	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
863767002998	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
863767002999	homodimer interface [polypeptide binding]; other site
863767003000	substrate-cofactor binding pocket; other site
863767003001	catalytic residue [active]
863767003002	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
863767003003	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767003004	Walker A/P-loop; other site
863767003005	ATP binding site [chemical binding]; other site
863767003006	Q-loop/lid; other site
863767003007	ABC transporter signature motif; other site
863767003008	Walker B; other site
863767003009	D-loop; other site
863767003010	H-loop/switch region; other site
863767003011	ABC-2 type transporter; Region: ABC2_membrane; cl17235
863767003012	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
863767003013	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767003014	Major Facilitator Superfamily; Region: MFS_1; pfam07690
863767003015	putative substrate translocation pore; other site
863767003016	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
863767003017	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
863767003018	putative oligomer interface [polypeptide binding]; other site
863767003019	putative active site [active]
863767003020	metal binding site [ion binding]; metal-binding site
863767003021	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
863767003022	catalytic residues [active]
863767003023	dimer interface [polypeptide binding]; other site
863767003024	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
863767003025	LytTr DNA-binding domain; Region: LytTR; pfam04397
863767003026	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
863767003027	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767003028	Walker A/P-loop; other site
863767003029	ATP binding site [chemical binding]; other site
863767003030	Q-loop/lid; other site
863767003031	ABC transporter signature motif; other site
863767003032	Walker B; other site
863767003033	D-loop; other site
863767003034	H-loop/switch region; other site
863767003035	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829
863767003036	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
863767003037	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
863767003038	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
863767003039	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
863767003040	G1 box; other site
863767003041	putative GEF interaction site [polypeptide binding]; other site
863767003042	GTP/Mg2+ binding site [chemical binding]; other site
863767003043	Switch I region; other site
863767003044	G2 box; other site
863767003045	G3 box; other site
863767003046	Switch II region; other site
863767003047	G4 box; other site
863767003048	G5 box; other site
863767003049	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
863767003050	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
863767003051	MarR family; Region: MarR_2; cl17246
863767003052	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
863767003053	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
863767003054	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
863767003055	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
863767003056	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
863767003057	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
863767003058	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
863767003059	Acyltransferase family; Region: Acyl_transf_3; pfam01757
863767003060	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
863767003061	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
863767003062	DNA binding site [nucleotide binding]
863767003063	active site
863767003064	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
863767003065	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767003066	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
863767003067	Walker A motif; other site
863767003068	ATP binding site [chemical binding]; other site
863767003069	Walker B motif; other site
863767003070	arginine finger; other site
863767003071	UvrB/uvrC motif; Region: UVR; pfam02151
863767003072	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767003073	Walker A motif; other site
863767003074	ATP binding site [chemical binding]; other site
863767003075	Walker B motif; other site
863767003076	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
863767003077	CAAX protease self-immunity; Region: Abi; pfam02517
863767003078	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
863767003079	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
863767003080	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
863767003081	nucleotide binding site [chemical binding]; other site
863767003082	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873
863767003083	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
863767003084	dimerization domain swap beta strand [polypeptide binding]; other site
863767003085	regulatory protein interface [polypeptide binding]; other site
863767003086	active site
863767003087	regulatory phosphorylation site [posttranslational modification]; other site
863767003088	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
863767003089	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
863767003090	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
863767003091	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
863767003092	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
863767003093	Uncharacterized conserved protein [Function unknown]; Region: COG1434
863767003094	putative active site [active]
863767003095	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
863767003096	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
863767003097	aminotransferase A; Validated; Region: PRK07683
863767003098	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
863767003099	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767003100	homodimer interface [polypeptide binding]; other site
863767003101	catalytic residue [active]
863767003102	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
863767003103	FOG: CBS domain [General function prediction only]; Region: COG0517
863767003104	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
863767003105	Transcriptional regulator [Transcription]; Region: LysR; COG0583
863767003106	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
863767003107	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
863767003108	dimerization interface [polypeptide binding]; other site
863767003109	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
863767003110	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
863767003111	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
863767003112	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
863767003113	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
863767003114	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
863767003115	metal binding site [ion binding]; metal-binding site
863767003116	putative dimer interface [polypeptide binding]; other site
863767003117	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
863767003118	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
863767003119	Mechanosensitive ion channel; Region: MS_channel; pfam00924
863767003120	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
863767003121	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767003122	Walker A/P-loop; other site
863767003123	ATP binding site [chemical binding]; other site
863767003124	Q-loop/lid; other site
863767003125	ABC transporter signature motif; other site
863767003126	Walker B; other site
863767003127	D-loop; other site
863767003128	H-loop/switch region; other site
863767003129	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
863767003130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767003131	dimer interface [polypeptide binding]; other site
863767003132	conserved gate region; other site
863767003133	putative PBP binding loops; other site
863767003134	ABC-ATPase subunit interface; other site
863767003135	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
863767003136	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
863767003137	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
863767003138	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
863767003139	HPr interaction site; other site
863767003140	glycerol kinase (GK) interaction site [polypeptide binding]; other site
863767003141	active site
863767003142	phosphorylation site [posttranslational modification]
863767003143	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
863767003144	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
863767003145	S1 domain; Region: S1_2; pfam13509
863767003146	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
863767003147	RNA binding site [nucleotide binding]; other site
863767003148	Predicted membrane protein [Function unknown]; Region: COG4758
863767003149	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
863767003150	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
863767003151	Histidine kinase; Region: HisKA_3; pfam07730
863767003152	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767003153	ATP binding site [chemical binding]; other site
863767003154	Mg2+ binding site [ion binding]; other site
863767003155	G-X-G motif; other site
863767003156	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
863767003157	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767003158	active site
863767003159	phosphorylation site [posttranslational modification]
863767003160	intermolecular recognition site; other site
863767003161	dimerization interface [polypeptide binding]; other site
863767003162	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
863767003163	DNA binding residues [nucleotide binding]
863767003164	dimerization interface [polypeptide binding]; other site
863767003165	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
863767003166	TrkA-N domain; Region: TrkA_N; pfam02254
863767003167	TrkA-C domain; Region: TrkA_C; pfam02080
863767003168	Predicted membrane protein [Function unknown]; Region: COG1289
863767003169	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
863767003170	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
863767003171	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
863767003172	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
863767003173	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
863767003174	hypothetical protein; Provisional; Region: PRK13667
863767003175	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
863767003176	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767003177	active site
863767003178	motif I; other site
863767003179	motif II; other site
863767003180	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767003181	Transcriptional regulators [Transcription]; Region: PurR; COG1609
863767003182	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
863767003183	DNA binding site [nucleotide binding]
863767003184	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
863767003185	ligand binding site [chemical binding]; other site
863767003186	dimerization interface [polypeptide binding]; other site
863767003187	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
863767003188	hexamer (dimer of trimers) interface [polypeptide binding]; other site
863767003189	trimer interface [polypeptide binding]; other site
863767003190	substrate binding site [chemical binding]; other site
863767003191	Mn binding site [ion binding]; other site
863767003192	transketolase; Reviewed; Region: PRK05899
863767003193	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
863767003194	TPP-binding site [chemical binding]; other site
863767003195	dimer interface [polypeptide binding]; other site
863767003196	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
863767003197	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
863767003198	PYR/PP interface [polypeptide binding]; other site
863767003199	dimer interface [polypeptide binding]; other site
863767003200	TPP binding site [chemical binding]; other site
863767003201	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
863767003202	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
863767003203	Uncharacterized subgroup; belongs to the glycerol kinases subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK_1; cd10427
863767003204	N- and C-terminal domain interface [polypeptide binding]; other site
863767003205	active site
863767003206	MgATP binding site [chemical binding]; other site
863767003207	catalytic site [active]
863767003208	metal binding site [ion binding]; metal-binding site
863767003209	putative glycerol binding site [chemical binding]; other site
863767003210	putative homotetramer interface [polypeptide binding]; other site
863767003211	putative homodimer interface [polypeptide binding]; other site
863767003212	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
863767003213	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
863767003214	active site turn [active]
863767003215	phosphorylation site [posttranslational modification]
863767003216	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
863767003217	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
863767003218	HPr interaction site; other site
863767003219	glycerol kinase (GK) interaction site [polypeptide binding]; other site
863767003220	active site
863767003221	phosphorylation site [posttranslational modification]
863767003222	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
863767003223	Uncharacterized integral membrane protein [Function unknown]; Region: COG3739
863767003224	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
863767003225	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
863767003226	GTP binding site; other site
863767003227	ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297
863767003228	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
863767003229	Walker A/P-loop; other site
863767003230	ATP binding site [chemical binding]; other site
863767003231	Q-loop/lid; other site
863767003232	ABC transporter signature motif; other site
863767003233	Walker B; other site
863767003234	D-loop; other site
863767003235	H-loop/switch region; other site
863767003236	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767003237	dimer interface [polypeptide binding]; other site
863767003238	conserved gate region; other site
863767003239	putative PBP binding loops; other site
863767003240	ABC-ATPase subunit interface; other site
863767003241	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
863767003242	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
863767003243	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
863767003244	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
863767003245	dimer interface [polypeptide binding]; other site
863767003246	putative functional site; other site
863767003247	putative MPT binding site; other site
863767003248	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
863767003249	Walker A motif; other site
863767003250	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
863767003251	MoaE homodimer interface [polypeptide binding]; other site
863767003252	MoaD interaction [polypeptide binding]; other site
863767003253	active site residues [active]
863767003254	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
863767003255	MoaE interaction surface [polypeptide binding]; other site
863767003256	MoeB interaction surface [polypeptide binding]; other site
863767003257	thiocarboxylated glycine; other site
863767003258	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
863767003259	trimer interface [polypeptide binding]; other site
863767003260	dimer interface [polypeptide binding]; other site
863767003261	putative active site [active]
863767003262	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
863767003263	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
863767003264	FeS/SAM binding site; other site
863767003265	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
863767003266	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
863767003267	MPT binding site; other site
863767003268	trimer interface [polypeptide binding]; other site
863767003269	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
863767003270	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
863767003271	ATP binding site [chemical binding]; other site
863767003272	substrate interface [chemical binding]; other site
863767003273	Flavin Reductases; Region: FlaRed; cl00801
863767003274	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
863767003275	active site
863767003276	catalytic residues [active]
863767003277	metal binding site [ion binding]; metal-binding site
863767003278	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
863767003279	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
863767003280	TPP-binding site [chemical binding]; other site
863767003281	tetramer interface [polypeptide binding]; other site
863767003282	heterodimer interface [polypeptide binding]; other site
863767003283	phosphorylation loop region [posttranslational modification]
863767003284	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
863767003285	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
863767003286	alpha subunit interface [polypeptide binding]; other site
863767003287	TPP binding site [chemical binding]; other site
863767003288	heterodimer interface [polypeptide binding]; other site
863767003289	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
863767003290	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
863767003291	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
863767003292	E3 interaction surface; other site
863767003293	lipoyl attachment site [posttranslational modification]; other site
863767003294	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
863767003295	E3 interaction surface; other site
863767003296	lipoyl attachment site [posttranslational modification]; other site
863767003297	e3 binding domain; Region: E3_binding; pfam02817
863767003298	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
863767003299	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
863767003300	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
863767003301	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
863767003302	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
863767003303	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
863767003304	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
863767003305	NAD(P) binding site [chemical binding]; other site
863767003306	LDH/MDH dimer interface [polypeptide binding]; other site
863767003307	substrate binding site [chemical binding]; other site
863767003308	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476
863767003309	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
863767003310	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
863767003311	catalytic residues [active]
863767003312	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
863767003313	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
863767003314	Cl binding site [ion binding]; other site
863767003315	oligomer interface [polypeptide binding]; other site
863767003316	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
863767003317	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
863767003318	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
863767003319	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
863767003320	active site
863767003321	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
863767003322	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
863767003323	G1 box; other site
863767003324	putative GEF interaction site [polypeptide binding]; other site
863767003325	GTP/Mg2+ binding site [chemical binding]; other site
863767003326	Switch I region; other site
863767003327	G2 box; other site
863767003328	G3 box; other site
863767003329	Switch II region; other site
863767003330	G4 box; other site
863767003331	G5 box; other site
863767003332	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
863767003333	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
863767003334	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896
863767003335	hypothetical protein; Provisional; Region: PRK13666
863767003336	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
863767003337	pyruvate carboxylase; Reviewed; Region: PRK12999
863767003338	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
863767003339	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
863767003340	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
863767003341	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
863767003342	active site
863767003343	catalytic residues [active]
863767003344	metal binding site [ion binding]; metal-binding site
863767003345	homodimer binding site [polypeptide binding]; other site
863767003346	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
863767003347	carboxyltransferase (CT) interaction site; other site
863767003348	biotinylation site [posttranslational modification]; other site
863767003349	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
863767003350	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
863767003351	putative binding site residues; other site
863767003352	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
863767003353	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
863767003354	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
863767003355	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
863767003356	Walker A/P-loop; other site
863767003357	ATP binding site [chemical binding]; other site
863767003358	Q-loop/lid; other site
863767003359	ABC transporter signature motif; other site
863767003360	Walker B; other site
863767003361	D-loop; other site
863767003362	H-loop/switch region; other site
863767003363	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
863767003364	SH3-like domain; Region: SH3_8; pfam13457
863767003365	SH3-like domain; Region: SH3_8; pfam13457
863767003366	SH3-like domain; Region: SH3_8; pfam13457
863767003367	SH3-like domain; Region: SH3_8; pfam13457
863767003368	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
863767003369	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
863767003370	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
863767003371	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
863767003372	active site
863767003373	tetramer interface; other site
863767003374	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
863767003375	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131
863767003376	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
863767003377	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
863767003378	active site
863767003379	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
863767003380	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
863767003381	substrate binding site; other site
863767003382	tetramer interface; other site
863767003383	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
863767003384	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
863767003385	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
863767003386	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
863767003387	NAD binding site [chemical binding]; other site
863767003388	substrate binding site [chemical binding]; other site
863767003389	homodimer interface [polypeptide binding]; other site
863767003390	active site
863767003391	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
863767003392	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
863767003393	NADP binding site [chemical binding]; other site
863767003394	active site
863767003395	putative substrate binding site [chemical binding]; other site
863767003396	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
863767003397	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
863767003398	substrate binding site; other site
863767003399	dimer interface; other site
863767003400	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
863767003401	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
863767003402	putative NAD(P) binding site [chemical binding]; other site
863767003403	putative catalytic Zn binding site [ion binding]; other site
863767003404	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
863767003405	glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171
863767003406	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
863767003407	active site
863767003408	putative glycosyl transferase; Provisional; Region: PRK10073
863767003409	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
863767003410	active site
863767003411	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
863767003412	active site
863767003413	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
863767003414	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
863767003415	active site
863767003416	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
863767003417	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
863767003418	homodimer interface [polypeptide binding]; other site
863767003419	NAD binding pocket [chemical binding]; other site
863767003420	ATP binding pocket [chemical binding]; other site
863767003421	Mg binding site [ion binding]; other site
863767003422	active-site loop [active]
863767003423	Uncharacterized conserved protein [Function unknown]; Region: COG1359
863767003424	Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440
863767003425	active site
863767003426	P-loop; other site
863767003427	phosphorylation site [posttranslational modification]
863767003428	GMP synthase; Reviewed; Region: guaA; PRK00074
863767003429	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
863767003430	AMP/PPi binding site [chemical binding]; other site
863767003431	candidate oxyanion hole; other site
863767003432	catalytic triad [active]
863767003433	potential glutamine specificity residues [chemical binding]; other site
863767003434	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
863767003435	ATP Binding subdomain [chemical binding]; other site
863767003436	Dimerization subdomain; other site
863767003437	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
863767003438	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
863767003439	active site
863767003440	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
863767003441	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767003442	Walker A/P-loop; other site
863767003443	ATP binding site [chemical binding]; other site
863767003444	Q-loop/lid; other site
863767003445	ABC transporter signature motif; other site
863767003446	Walker B; other site
863767003447	D-loop; other site
863767003448	H-loop/switch region; other site
863767003449	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
863767003450	putative FMN binding site [chemical binding]; other site
863767003451	NADPH bind site [chemical binding]; other site
863767003452	thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603
863767003453	YcaO-like family; Region: YcaO; pfam02624
863767003454	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
863767003455	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
863767003456	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
863767003457	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
863767003458	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
863767003459	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
863767003460	Protein of unknown function (DUF3130; Region: DUF3130; cl12867
863767003461	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
863767003462	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
863767003463	MepB protein; Region: MepB; cl01985
863767003464	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
863767003465	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
863767003466	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
863767003467	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767003468	Coenzyme A binding pocket [chemical binding]; other site
863767003469	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
863767003470	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
863767003471	DNA binding residues [nucleotide binding]
863767003472	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
863767003473	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
863767003474	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767003475	Walker A/P-loop; other site
863767003476	ATP binding site [chemical binding]; other site
863767003477	Q-loop/lid; other site
863767003478	ABC transporter signature motif; other site
863767003479	Walker B; other site
863767003480	D-loop; other site
863767003481	H-loop/switch region; other site
863767003482	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
863767003483	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
863767003484	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767003485	Walker A/P-loop; other site
863767003486	ATP binding site [chemical binding]; other site
863767003487	Q-loop/lid; other site
863767003488	ABC transporter signature motif; other site
863767003489	Walker B; other site
863767003490	D-loop; other site
863767003491	H-loop/switch region; other site
863767003492	Uncharacterized conserved protein [Function unknown]; Region: COG1359
863767003493	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
863767003494	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
863767003495	DNA binding residues [nucleotide binding]
863767003496	putative dimer interface [polypeptide binding]; other site
863767003497	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
863767003498	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
863767003499	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
863767003500	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
863767003501	LRR adjacent; Region: LRR_adjacent; pfam08191
863767003502	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767003503	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
863767003504	Clp protease; Region: CLP_protease; pfam00574
863767003505	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
863767003506	oligomer interface [polypeptide binding]; other site
863767003507	active site residues [active]
863767003508	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
863767003509	dimer interface [polypeptide binding]; other site
863767003510	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
863767003511	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
863767003512	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
863767003513	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
863767003514	SLBB domain; Region: SLBB; pfam10531
863767003515	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
863767003516	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
863767003517	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
863767003518	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
863767003519	putative hexamer interface [polypeptide binding]; other site
863767003520	putative hexagonal pore; other site
863767003521	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
863767003522	putative hexamer interface [polypeptide binding]; other site
863767003523	putative hexagonal pore; other site
863767003524	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
863767003525	putative hexamer interface [polypeptide binding]; other site
863767003526	putative hexagonal pore; other site
863767003527	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
863767003528	G1 box; other site
863767003529	GTP/Mg2+ binding site [chemical binding]; other site
863767003530	G2 box; other site
863767003531	Switch I region; other site
863767003532	G3 box; other site
863767003533	Switch II region; other site
863767003534	G4 box; other site
863767003535	G5 box; other site
863767003536	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
863767003537	homotrimer interface [polypeptide binding]; other site
863767003538	Walker A motif; other site
863767003539	GTP binding site [chemical binding]; other site
863767003540	Walker B motif; other site
863767003541	Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368
863767003542	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
863767003543	catalytic core [active]
863767003544	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
863767003545	Sensory domain found in PocR; Region: PocR; pfam10114
863767003546	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
863767003547	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
863767003548	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
863767003549	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
863767003550	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
863767003551	Hexamer interface [polypeptide binding]; other site
863767003552	Hexagonal pore residue; other site
863767003553	propanediol utilization protein PduB; Provisional; Region: PRK15415
863767003554	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
863767003555	putative hexamer interface [polypeptide binding]; other site
863767003556	putative hexagonal pore; other site
863767003557	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
863767003558	putative hexamer interface [polypeptide binding]; other site
863767003559	putative hexagonal pore; other site
863767003560	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
863767003561	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
863767003562	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
863767003563	alpha-beta subunit interface [polypeptide binding]; other site
863767003564	alpha-gamma subunit interface [polypeptide binding]; other site
863767003565	active site
863767003566	substrate and K+ binding site; other site
863767003567	K+ binding site [ion binding]; other site
863767003568	cobalamin binding site [chemical binding]; other site
863767003569	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
863767003570	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
863767003571	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
863767003572	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
863767003573	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
863767003574	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
863767003575	putative hexamer interface [polypeptide binding]; other site
863767003576	putative hexagonal pore; other site
863767003577	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
863767003578	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
863767003579	Hexamer interface [polypeptide binding]; other site
863767003580	Hexagonal pore residue; other site
863767003581	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
863767003582	Propanediol utilisation protein PduL; Region: PduL; pfam06130
863767003583	Propanediol utilisation protein PduL; Region: PduL; pfam06130
863767003584	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
863767003585	Cell division protein FtsA; Region: FtsA; cl17206
863767003586	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
863767003587	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
863767003588	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
863767003589	Hexamer/Pentamer interface [polypeptide binding]; other site
863767003590	central pore; other site
863767003591	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
863767003592	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
863767003593	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
863767003594	putative catalytic cysteine [active]
863767003595	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
863767003596	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
863767003597	putative active site [active]
863767003598	metal binding site [ion binding]; metal-binding site
863767003599	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
863767003600	amphipathic channel; other site
863767003601	Asn-Pro-Ala signature motifs; other site
863767003602	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
863767003603	propionate/acetate kinase; Provisional; Region: PRK12379
863767003604	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
863767003605	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
863767003606	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767003607	homodimer interface [polypeptide binding]; other site
863767003608	catalytic residue [active]
863767003609	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
863767003610	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
863767003611	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
863767003612	putative active site [active]
863767003613	metal binding site [ion binding]; metal-binding site
863767003614	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
863767003615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767003616	active site
863767003617	phosphorylation site [posttranslational modification]
863767003618	intermolecular recognition site; other site
863767003619	dimerization interface [polypeptide binding]; other site
863767003620	ANTAR domain; Region: ANTAR; pfam03861
863767003621	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
863767003622	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
863767003623	Histidine kinase; Region: HisKA_2; pfam07568
863767003624	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767003625	ATP binding site [chemical binding]; other site
863767003626	Mg2+ binding site [ion binding]; other site
863767003627	G-X-G motif; other site
863767003628	Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819
863767003629	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
863767003630	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
863767003631	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
863767003632	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
863767003633	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
863767003634	putative hexamer interface [polypeptide binding]; other site
863767003635	putative hexagonal pore; other site
863767003636	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
863767003637	putative hexamer interface [polypeptide binding]; other site
863767003638	putative hexagonal pore; other site
863767003639	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
863767003640	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
863767003641	Hexamer interface [polypeptide binding]; other site
863767003642	Hexagonal pore residue; other site
863767003643	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
863767003644	putative catalytic cysteine [active]
863767003645	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
863767003646	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
863767003647	Hexamer interface [polypeptide binding]; other site
863767003648	Putative hexagonal pore residue; other site
863767003649	Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812
863767003650	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
863767003651	Propanediol utilisation protein PduL; Region: PduL; pfam06130
863767003652	Propanediol utilisation protein PduL; Region: PduL; pfam06130
863767003653	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
863767003654	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
863767003655	Hexamer/Pentamer interface [polypeptide binding]; other site
863767003656	central pore; other site
863767003657	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
863767003658	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
863767003659	putative hexamer interface [polypeptide binding]; other site
863767003660	putative hexagonal pore; other site
863767003661	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
863767003662	putative hexamer interface [polypeptide binding]; other site
863767003663	putative hexagonal pore; other site
863767003664	Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346
863767003665	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
863767003666	Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249
863767003667	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
863767003668	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
863767003669	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
863767003670	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
863767003671	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
863767003672	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
863767003673	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
863767003674	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
863767003675	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
863767003676	catalytic triad [active]
863767003677	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
863767003678	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
863767003679	Precorrin-8X methylmutase; Region: CbiC; pfam02570
863767003680	Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903
863767003681	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
863767003682	active site
863767003683	putative homodimer interface [polypeptide binding]; other site
863767003684	SAM binding site [chemical binding]; other site
863767003685	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
863767003686	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767003687	S-adenosylmethionine binding site [chemical binding]; other site
863767003688	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
863767003689	active site
863767003690	SAM binding site [chemical binding]; other site
863767003691	homodimer interface [polypeptide binding]; other site
863767003692	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
863767003693	active site
863767003694	SAM binding site [chemical binding]; other site
863767003695	homodimer interface [polypeptide binding]; other site
863767003696	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
863767003697	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
863767003698	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
863767003699	active site
863767003700	SAM binding site [chemical binding]; other site
863767003701	homodimer interface [polypeptide binding]; other site
863767003702	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
863767003703	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
863767003704	active site
863767003705	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
863767003706	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
863767003707	active site
863767003708	C-terminal domain interface [polypeptide binding]; other site
863767003709	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
863767003710	active site
863767003711	N-terminal domain interface [polypeptide binding]; other site
863767003712	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
863767003713	active site
863767003714	SAM binding site [chemical binding]; other site
863767003715	homodimer interface [polypeptide binding]; other site
863767003716	cobalt transport protein CbiM; Validated; Region: PRK08319
863767003717	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
863767003718	ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930
863767003719	cobalt transport protein CbiQ; Provisional; Region: PRK15485
863767003720	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
863767003721	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
863767003722	Walker A/P-loop; other site
863767003723	ATP binding site [chemical binding]; other site
863767003724	Q-loop/lid; other site
863767003725	ABC transporter signature motif; other site
863767003726	Walker B; other site
863767003727	D-loop; other site
863767003728	H-loop/switch region; other site
863767003729	cobyric acid synthase; Provisional; Region: PRK00784
863767003730	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
863767003731	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
863767003732	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
863767003733	catalytic triad [active]
863767003734	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
863767003735	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
863767003736	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
863767003737	AAA domain; Region: AAA_17; cl17253
863767003738	Predicted transcriptional regulators [Transcription]; Region: COG1695
863767003739	Transcriptional regulator PadR-like family; Region: PadR; cl17335
863767003740	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
863767003741	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
863767003742	SH3-like domain; Region: SH3_8; pfam13457
863767003743	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
863767003744	SH3-like domain; Region: SH3_8; pfam13457
863767003745	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
863767003746	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
863767003747	oligomer interface [polypeptide binding]; other site
863767003748	active site
863767003749	metal binding site [ion binding]; metal-binding site
863767003750	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
863767003751	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
863767003752	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
863767003753	Predicted transcriptional regulators [Transcription]; Region: COG1733
863767003754	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
863767003755	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
863767003756	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
863767003757	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
863767003758	dimer interface [polypeptide binding]; other site
863767003759	motif 1; other site
863767003760	active site
863767003761	motif 2; other site
863767003762	motif 3; other site
863767003763	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
863767003764	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
863767003765	putative tRNA-binding site [nucleotide binding]; other site
863767003766	B3/4 domain; Region: B3_4; pfam03483
863767003767	tRNA synthetase B5 domain; Region: B5; smart00874
863767003768	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
863767003769	dimer interface [polypeptide binding]; other site
863767003770	motif 1; other site
863767003771	motif 3; other site
863767003772	motif 2; other site
863767003773	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
863767003774	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
863767003775	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
863767003776	Walker A/P-loop; other site
863767003777	ATP binding site [chemical binding]; other site
863767003778	Q-loop/lid; other site
863767003779	ABC transporter signature motif; other site
863767003780	Walker B; other site
863767003781	D-loop; other site
863767003782	H-loop/switch region; other site
863767003783	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
863767003784	FtsX-like permease family; Region: FtsX; pfam02687
863767003785	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
863767003786	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
863767003787	FtsX-like permease family; Region: FtsX; pfam02687
863767003788	Transcriptional regulators [Transcription]; Region: MarR; COG1846
863767003789	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
863767003790	putative DNA binding site [nucleotide binding]; other site
863767003791	putative Zn2+ binding site [ion binding]; other site
863767003792	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
863767003793	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
863767003794	ligand binding site [chemical binding]; other site
863767003795	active site
863767003796	UGI interface [polypeptide binding]; other site
863767003797	catalytic site [active]
863767003798	ribonuclease HIII; Provisional; Region: PRK00996
863767003799	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
863767003800	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
863767003801	RNA/DNA hybrid binding site [nucleotide binding]; other site
863767003802	active site
863767003803	Cell division protein ZapA; Region: ZapA; cl01146
863767003804	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
863767003805	Colicin V production protein; Region: Colicin_V; pfam02674
863767003806	hypothetical protein; Provisional; Region: PRK08609
863767003807	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
863767003808	active site
863767003809	primer binding site [nucleotide binding]; other site
863767003810	NTP  binding site [chemical binding]; other site
863767003811	metal binding triad [ion binding]; metal-binding site
863767003812	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
863767003813	active site
863767003814	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
863767003815	MutS domain III; Region: MutS_III; pfam05192
863767003816	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767003817	Walker A/P-loop; other site
863767003818	ATP binding site [chemical binding]; other site
863767003819	Q-loop/lid; other site
863767003820	ABC transporter signature motif; other site
863767003821	Walker B; other site
863767003822	D-loop; other site
863767003823	H-loop/switch region; other site
863767003824	Smr domain; Region: Smr; pfam01713
863767003825	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
863767003826	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
863767003827	catalytic residues [active]
863767003828	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
863767003829	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
863767003830	GIY-YIG motif/motif A; other site
863767003831	active site
863767003832	catalytic site [active]
863767003833	putative DNA binding site [nucleotide binding]; other site
863767003834	metal binding site [ion binding]; metal-binding site
863767003835	UvrB/uvrC motif; Region: UVR; pfam02151
863767003836	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
863767003837	aspartate kinase; Reviewed; Region: PRK06635
863767003838	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
863767003839	putative nucleotide binding site [chemical binding]; other site
863767003840	putative catalytic residues [active]
863767003841	putative Mg ion binding site [ion binding]; other site
863767003842	putative aspartate binding site [chemical binding]; other site
863767003843	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
863767003844	putative allosteric regulatory site; other site
863767003845	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
863767003846	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
863767003847	Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796
863767003848	ribonuclease PH; Reviewed; Region: rph; PRK00173
863767003849	Ribonuclease PH; Region: RNase_PH_bact; cd11362
863767003850	hexamer interface [polypeptide binding]; other site
863767003851	active site
863767003852	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
863767003853	active site
863767003854	dimerization interface [polypeptide binding]; other site
863767003855	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
863767003856	active site
863767003857	metal binding site [ion binding]; metal-binding site
863767003858	homotetramer interface [polypeptide binding]; other site
863767003859	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
863767003860	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
863767003861	LRR adjacent; Region: LRR_adjacent; pfam08191
863767003862	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767003863	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767003864	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767003865	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767003866	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767003867	Uncharacterized conserved protein [Function unknown]; Region: COG5361
863767003868	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
863767003869	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
863767003870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
863767003871	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
863767003872	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
863767003873	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
863767003874	dimer interface [polypeptide binding]; other site
863767003875	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
863767003876	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
863767003877	catalytic core [active]
863767003878	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
863767003879	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
863767003880	ATP binding site [chemical binding]; other site
863767003881	Mg++ binding site [ion binding]; other site
863767003882	motif III; other site
863767003883	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
863767003884	nucleotide binding region [chemical binding]; other site
863767003885	ATP-binding site [chemical binding]; other site
863767003886	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
863767003887	RNA binding site [nucleotide binding]; other site
863767003888	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
863767003889	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
863767003890	putative active site [active]
863767003891	nucleotide binding site [chemical binding]; other site
863767003892	nudix motif; other site
863767003893	putative metal binding site [ion binding]; other site
863767003894	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767003895	Major Facilitator Superfamily; Region: MFS_1; pfam07690
863767003896	putative substrate translocation pore; other site
863767003897	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767003898	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
863767003899	ligand binding site [chemical binding]; other site
863767003900	flexible hinge region; other site
863767003901	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
863767003902	Uncharacterized conserved protein [Function unknown]; Region: COG1284
863767003903	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
863767003904	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
863767003905	UTRA domain; Region: UTRA; pfam07702
863767003906	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
863767003907	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
863767003908	Ca binding site [ion binding]; other site
863767003909	active site
863767003910	catalytic site [active]
863767003911	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
863767003912	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
863767003913	active site turn [active]
863767003914	phosphorylation site [posttranslational modification]
863767003915	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
863767003916	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
863767003917	nudix motif; other site
863767003918	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
863767003919	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
863767003920	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
863767003921	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
863767003922	putative catalytic cysteine [active]
863767003923	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
863767003924	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
863767003925	nucleotide binding site [chemical binding]; other site
863767003926	homotetrameric interface [polypeptide binding]; other site
863767003927	putative phosphate binding site [ion binding]; other site
863767003928	putative allosteric binding site; other site
863767003929	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
863767003930	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
863767003931	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
863767003932	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767003933	non-specific DNA binding site [nucleotide binding]; other site
863767003934	salt bridge; other site
863767003935	sequence-specific DNA binding site [nucleotide binding]; other site
863767003936	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767003937	non-specific DNA binding site [nucleotide binding]; other site
863767003938	salt bridge; other site
863767003939	sequence-specific DNA binding site [nucleotide binding]; other site
863767003940	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
863767003941	active site
863767003942	trigger factor; Provisional; Region: tig; PRK01490
863767003943	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
863767003944	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
863767003945	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
863767003946	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
863767003947	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767003948	Walker A motif; other site
863767003949	ATP binding site [chemical binding]; other site
863767003950	Walker B motif; other site
863767003951	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
863767003952	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
863767003953	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
863767003954	Catalytic site [active]
863767003955	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
863767003956	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
863767003957	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
863767003958	Catalytic site [active]
863767003959	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
863767003960	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
863767003961	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
863767003962	Catalytic site [active]
863767003963	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
863767003964	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
863767003965	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
863767003966	GTP/Mg2+ binding site [chemical binding]; other site
863767003967	G4 box; other site
863767003968	G5 box; other site
863767003969	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
863767003970	G1 box; other site
863767003971	G1 box; other site
863767003972	GTP/Mg2+ binding site [chemical binding]; other site
863767003973	Switch I region; other site
863767003974	G2 box; other site
863767003975	G2 box; other site
863767003976	G3 box; other site
863767003977	G3 box; other site
863767003978	Switch II region; other site
863767003979	Switch II region; other site
863767003980	G5 box; other site
863767003981	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
863767003982	RNA/DNA hybrid binding site [nucleotide binding]; other site
863767003983	active site
863767003984	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
863767003985	DNA protecting protein DprA; Region: dprA; TIGR00732
863767003986	DNA topoisomerase I; Validated; Region: PRK05582
863767003987	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
863767003988	active site
863767003989	interdomain interaction site; other site
863767003990	putative metal-binding site [ion binding]; other site
863767003991	nucleotide binding site [chemical binding]; other site
863767003992	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
863767003993	domain I; other site
863767003994	DNA binding groove [nucleotide binding]
863767003995	phosphate binding site [ion binding]; other site
863767003996	domain II; other site
863767003997	domain III; other site
863767003998	nucleotide binding site [chemical binding]; other site
863767003999	catalytic site [active]
863767004000	domain IV; other site
863767004001	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
863767004002	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
863767004003	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
863767004004	Glucose inhibited division protein A; Region: GIDA; pfam01134
863767004005	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
863767004006	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
863767004007	active site
863767004008	DNA binding site [nucleotide binding]
863767004009	Int/Topo IB signature motif; other site
863767004010	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
863767004011	active site
863767004012	HslU subunit interaction site [polypeptide binding]; other site
863767004013	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
863767004014	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767004015	Walker A motif; other site
863767004016	ATP binding site [chemical binding]; other site
863767004017	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
863767004018	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
863767004019	transcriptional repressor CodY; Validated; Region: PRK04158
863767004020	CodY GAF-like domain; Region: CodY; pfam06018
863767004021	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
863767004022	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
863767004023	active site
863767004024	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
863767004025	active site
863767004026	catalytic residues [active]
863767004027	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
863767004028	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
863767004029	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
863767004030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767004031	Mg2+ binding site [ion binding]; other site
863767004032	G-X-G motif; other site
863767004033	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
863767004034	anchoring element; other site
863767004035	dimer interface [polypeptide binding]; other site
863767004036	ATP binding site [chemical binding]; other site
863767004037	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
863767004038	active site
863767004039	putative metal-binding site [ion binding]; other site
863767004040	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
863767004041	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
863767004042	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
863767004043	CAP-like domain; other site
863767004044	active site
863767004045	primary dimer interface [polypeptide binding]; other site
863767004046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
863767004047	S-ribosylhomocysteinase; Provisional; Region: PRK02260
863767004048	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
863767004049	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767004050	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
863767004051	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
863767004052	catalytic triad [active]
863767004053	catalytic triad [active]
863767004054	oxyanion hole [active]
863767004055	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
863767004056	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
863767004057	active site
863767004058	catalytic site [active]
863767004059	metal binding site [ion binding]; metal-binding site
863767004060	dimer interface [polypeptide binding]; other site
863767004061	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
863767004062	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
863767004063	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
863767004064	bacterial Hfq-like; Region: Hfq; cd01716
863767004065	hexamer interface [polypeptide binding]; other site
863767004066	Sm1 motif; other site
863767004067	RNA binding site [nucleotide binding]; other site
863767004068	Sm2 motif; other site
863767004069	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
863767004070	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
863767004071	HflX GTPase family; Region: HflX; cd01878
863767004072	G1 box; other site
863767004073	GTP/Mg2+ binding site [chemical binding]; other site
863767004074	Switch I region; other site
863767004075	G2 box; other site
863767004076	G3 box; other site
863767004077	Switch II region; other site
863767004078	G4 box; other site
863767004079	G5 box; other site
863767004080	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
863767004081	Aluminium resistance protein; Region: Alum_res; pfam06838
863767004082	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
863767004083	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
863767004084	DNA binding residues [nucleotide binding]
863767004085	putative dimer interface [polypeptide binding]; other site
863767004086	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
863767004087	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
863767004088	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
863767004089	arsenical pump membrane protein; Provisional; Region: PRK15445
863767004090	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
863767004091	transmembrane helices; other site
863767004092	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
863767004093	LexA repressor; Validated; Region: PRK00215
863767004094	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
863767004095	putative DNA binding site [nucleotide binding]; other site
863767004096	putative Zn2+ binding site [ion binding]; other site
863767004097	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
863767004098	Catalytic site [active]
863767004099	cell division suppressor protein YneA; Provisional; Region: PRK14125
863767004100	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
863767004101	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
863767004102	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
863767004103	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
863767004104	TPP-binding site [chemical binding]; other site
863767004105	dimer interface [polypeptide binding]; other site
863767004106	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
863767004107	PYR/PP interface [polypeptide binding]; other site
863767004108	dimer interface [polypeptide binding]; other site
863767004109	TPP binding site [chemical binding]; other site
863767004110	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
863767004111	hypothetical protein; Provisional; Region: PRK01844
863767004112	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
863767004113	Methyltransferase domain; Region: Methyltransf_31; pfam13847
863767004114	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767004115	S-adenosylmethionine binding site [chemical binding]; other site
863767004116	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
863767004117	ParB-like nuclease domain; Region: ParBc; pfam02195
863767004118	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
863767004119	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
863767004120	Active Sites [active]
863767004121	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
863767004122	DEAD-like helicases superfamily; Region: DEXDc; smart00487
863767004123	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
863767004124	putative nucleotide binding site [chemical binding]; other site
863767004125	uridine monophosphate binding site [chemical binding]; other site
863767004126	homohexameric interface [polypeptide binding]; other site
863767004127	ribosome recycling factor; Reviewed; Region: frr; PRK00083
863767004128	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
863767004129	hinge region; other site
863767004130	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830
863767004131	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
863767004132	catalytic residue [active]
863767004133	putative FPP diphosphate  binding site; other site
863767004134	putative FPP binding hydrophobic cleft; other site
863767004135	dimer interface [polypeptide binding]; other site
863767004136	putative IPP diphosphate binding site; other site
863767004137	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
863767004138	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
863767004139	1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743
863767004140	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
863767004141	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
863767004142	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
863767004143	RIP metalloprotease RseP; Region: TIGR00054
863767004144	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
863767004145	active site
863767004146	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
863767004147	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
863767004148	protein binding site [polypeptide binding]; other site
863767004149	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
863767004150	putative substrate binding region [chemical binding]; other site
863767004151	prolyl-tRNA synthetase; Provisional; Region: PRK09194
863767004152	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
863767004153	dimer interface [polypeptide binding]; other site
863767004154	motif 1; other site
863767004155	active site
863767004156	motif 2; other site
863767004157	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
863767004158	putative deacylase active site [active]
863767004159	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
863767004160	active site
863767004161	motif 3; other site
863767004162	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
863767004163	anticodon binding site; other site
863767004164	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
863767004165	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
863767004166	generic binding surface I; other site
863767004167	DNA polymerase III, alpha chain, Gram-positive type; Region: polC_Gram_pos; TIGR01405
863767004168	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
863767004169	active site
863767004170	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
863767004171	active site
863767004172	catalytic site [active]
863767004173	substrate binding site [chemical binding]; other site
863767004174	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
863767004175	ribosome maturation protein RimP; Reviewed; Region: PRK00092
863767004176	Sm and related proteins; Region: Sm_like; cl00259
863767004177	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
863767004178	putative oligomer interface [polypeptide binding]; other site
863767004179	putative RNA binding site [nucleotide binding]; other site
863767004180	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
863767004181	NusA N-terminal domain; Region: NusA_N; pfam08529
863767004182	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
863767004183	RNA binding site [nucleotide binding]; other site
863767004184	homodimer interface [polypeptide binding]; other site
863767004185	NusA-like KH domain; Region: KH_5; pfam13184
863767004186	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
863767004187	G-X-X-G motif; other site
863767004188	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
863767004189	putative RNA binding cleft [nucleotide binding]; other site
863767004190	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
863767004191	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
863767004192	translation initiation factor IF-2; Region: IF-2; TIGR00487
863767004193	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
863767004194	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
863767004195	G1 box; other site
863767004196	putative GEF interaction site [polypeptide binding]; other site
863767004197	GTP/Mg2+ binding site [chemical binding]; other site
863767004198	Switch I region; other site
863767004199	G2 box; other site
863767004200	G3 box; other site
863767004201	Switch II region; other site
863767004202	G4 box; other site
863767004203	G5 box; other site
863767004204	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
863767004205	Translation-initiation factor 2; Region: IF-2; pfam11987
863767004206	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
863767004207	Protein of unknown function (DUF503); Region: DUF503; cl00669
863767004208	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
863767004209	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
863767004210	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
863767004211	RNA binding site [nucleotide binding]; other site
863767004212	active site
863767004213	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
863767004214	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
863767004215	active site
863767004216	Riboflavin kinase; Region: Flavokinase; smart00904
863767004217	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
863767004218	16S/18S rRNA binding site [nucleotide binding]; other site
863767004219	S13e-L30e interaction site [polypeptide binding]; other site
863767004220	25S rRNA binding site [nucleotide binding]; other site
863767004221	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
863767004222	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
863767004223	RNase E interface [polypeptide binding]; other site
863767004224	trimer interface [polypeptide binding]; other site
863767004225	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
863767004226	RNase E interface [polypeptide binding]; other site
863767004227	trimer interface [polypeptide binding]; other site
863767004228	active site
863767004229	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
863767004230	putative nucleic acid binding region [nucleotide binding]; other site
863767004231	G-X-X-G motif; other site
863767004232	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
863767004233	RNA binding site [nucleotide binding]; other site
863767004234	domain interface; other site
863767004235	GTPase RsgA; Reviewed; Region: PRK01889
863767004236	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
863767004237	RNA binding site [nucleotide binding]; other site
863767004238	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
863767004239	GTPase/Zn-binding domain interface [polypeptide binding]; other site
863767004240	GTP/Mg2+ binding site [chemical binding]; other site
863767004241	G4 box; other site
863767004242	G5 box; other site
863767004243	G1 box; other site
863767004244	Switch I region; other site
863767004245	G2 box; other site
863767004246	G3 box; other site
863767004247	Switch II region; other site
863767004248	YceG-like family; Region: YceG; pfam02618
863767004249	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
863767004250	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
863767004251	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
863767004252	Rhomboid family; Region: Rhomboid; pfam01694
863767004253	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
863767004254	TPR motif; other site
863767004255	TPR repeat; Region: TPR_11; pfam13414
863767004256	binding surface
863767004257	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
863767004258	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
863767004259	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
863767004260	nucleotide binding site [chemical binding]; other site
863767004261	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
863767004262	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
863767004263	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
863767004264	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
863767004265	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
863767004266	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
863767004267	Type II/IV secretion system protein; Region: T2SE; pfam00437
863767004268	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
863767004269	Walker A motif; other site
863767004270	ATP binding site [chemical binding]; other site
863767004271	Walker B motif; other site
863767004272	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
863767004273	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
863767004274	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
863767004275	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
863767004276	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
863767004277	tetramer interface [polypeptide binding]; other site
863767004278	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767004279	catalytic residue [active]
863767004280	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
863767004281	tetramer interface [polypeptide binding]; other site
863767004282	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767004283	catalytic residue [active]
863767004284	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
863767004285	active site residue [active]
863767004286	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
863767004287	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
863767004288	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
863767004289	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
863767004290	active site
863767004291	elongation factor P; Validated; Region: PRK00529
863767004292	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
863767004293	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
863767004294	RNA binding site [nucleotide binding]; other site
863767004295	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
863767004296	RNA binding site [nucleotide binding]; other site
863767004297	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
863767004298	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
863767004299	carboxyltransferase (CT) interaction site; other site
863767004300	biotinylation site [posttranslational modification]; other site
863767004301	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
863767004302	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
863767004303	ATP-grasp domain; Region: ATP-grasp_4; cl17255
863767004304	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
863767004305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
863767004306	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
863767004307	putative RNA binding site [nucleotide binding]; other site
863767004308	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170
863767004309	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
863767004310	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
863767004311	homodimer interface [polypeptide binding]; other site
863767004312	NADP binding site [chemical binding]; other site
863767004313	substrate binding site [chemical binding]; other site
863767004314	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
863767004315	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
863767004316	generic binding surface II; other site
863767004317	generic binding surface I; other site
863767004318	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064
863767004319	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
863767004320	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
863767004321	substrate binding pocket [chemical binding]; other site
863767004322	chain length determination region; other site
863767004323	substrate-Mg2+ binding site; other site
863767004324	catalytic residues [active]
863767004325	aspartate-rich region 1; other site
863767004326	active site lid residues [active]
863767004327	aspartate-rich region 2; other site
863767004328	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
863767004329	DNA-binding site [nucleotide binding]; DNA binding site
863767004330	RNA-binding motif; other site
863767004331	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
863767004332	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
863767004333	TPP-binding site; other site
863767004334	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
863767004335	PYR/PP interface [polypeptide binding]; other site
863767004336	dimer interface [polypeptide binding]; other site
863767004337	TPP binding site [chemical binding]; other site
863767004338	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
863767004339	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
863767004340	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
863767004341	RNA binding surface [nucleotide binding]; other site
863767004342	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
863767004343	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
863767004344	arginine repressor; Provisional; Region: PRK04280
863767004345	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
863767004346	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
863767004347	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
863767004348	Walker A/P-loop; other site
863767004349	ATP binding site [chemical binding]; other site
863767004350	Q-loop/lid; other site
863767004351	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
863767004352	ABC transporter signature motif; other site
863767004353	Walker B; other site
863767004354	D-loop; other site
863767004355	H-loop/switch region; other site
863767004356	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
863767004357	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
863767004358	nucleotide binding site [chemical binding]; other site
863767004359	Acetokinase family; Region: Acetate_kinase; cl17229
863767004360	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
863767004361	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
863767004362	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
863767004363	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
863767004364	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
863767004365	tetramer interface [polypeptide binding]; other site
863767004366	TPP-binding site [chemical binding]; other site
863767004367	heterodimer interface [polypeptide binding]; other site
863767004368	phosphorylation loop region [posttranslational modification]
863767004369	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
863767004370	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
863767004371	alpha subunit interface [polypeptide binding]; other site
863767004372	TPP binding site [chemical binding]; other site
863767004373	heterodimer interface [polypeptide binding]; other site
863767004374	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
863767004375	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
863767004376	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
863767004377	E3 interaction surface; other site
863767004378	lipoyl attachment site [posttranslational modification]; other site
863767004379	e3 binding domain; Region: E3_binding; pfam02817
863767004380	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
863767004381	peptidase T-like protein; Region: PepT-like; TIGR01883
863767004382	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
863767004383	metal binding site [ion binding]; metal-binding site
863767004384	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
863767004385	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
863767004386	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
863767004387	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
863767004388	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767004389	active site
863767004390	phosphorylation site [posttranslational modification]
863767004391	intermolecular recognition site; other site
863767004392	dimerization interface [polypeptide binding]; other site
863767004393	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
863767004394	DNA binding site [nucleotide binding]
863767004395	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
863767004396	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
863767004397	dimerization interface [polypeptide binding]; other site
863767004398	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
863767004399	dimer interface [polypeptide binding]; other site
863767004400	phosphorylation site [posttranslational modification]
863767004401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767004402	ATP binding site [chemical binding]; other site
863767004403	Mg2+ binding site [ion binding]; other site
863767004404	G-X-G motif; other site
863767004405	OxaA-like protein precursor; Validated; Region: PRK01622
863767004406	acylphosphatase; Provisional; Region: PRK14443
863767004407	Protein of unknown function (DUF1033); Region: DUF1033; cl11549
863767004408	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
863767004409	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
863767004410	homotetramer interface [polypeptide binding]; other site
863767004411	FMN binding site [chemical binding]; other site
863767004412	homodimer contacts [polypeptide binding]; other site
863767004413	putative active site [active]
863767004414	putative substrate binding site [chemical binding]; other site
863767004415	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
863767004416	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
863767004417	active site residue [active]
863767004418	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
863767004419	Uncharacterized conserved protein [Function unknown]; Region: COG1284
863767004420	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
863767004421	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
863767004422	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
863767004423	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
863767004424	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
863767004425	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
863767004426	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928
863767004427	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
863767004428	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
863767004429	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
863767004430	ligand binding site [chemical binding]; other site
863767004431	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
863767004432	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
863767004433	Walker A/P-loop; other site
863767004434	ATP binding site [chemical binding]; other site
863767004435	Q-loop/lid; other site
863767004436	ABC transporter signature motif; other site
863767004437	Walker B; other site
863767004438	D-loop; other site
863767004439	H-loop/switch region; other site
863767004440	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
863767004441	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
863767004442	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
863767004443	TM-ABC transporter signature motif; other site
863767004444	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
863767004445	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
863767004446	TM-ABC transporter signature motif; other site
863767004447	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
863767004448	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
863767004449	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
863767004450	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
863767004451	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
863767004452	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
863767004453	classical (c) SDRs; Region: SDR_c; cd05233
863767004454	NAD(P) binding site [chemical binding]; other site
863767004455	active site
863767004456	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
863767004457	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767004458	non-specific DNA binding site [nucleotide binding]; other site
863767004459	salt bridge; other site
863767004460	sequence-specific DNA binding site [nucleotide binding]; other site
863767004461	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
863767004462	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
863767004463	competence damage-inducible protein A; Provisional; Region: PRK00549
863767004464	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
863767004465	putative MPT binding site; other site
863767004466	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
863767004467	recombinase A; Provisional; Region: recA; PRK09354
863767004468	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
863767004469	hexamer interface [polypeptide binding]; other site
863767004470	Walker A motif; other site
863767004471	ATP binding site [chemical binding]; other site
863767004472	Walker B motif; other site
863767004473	phosphodiesterase; Provisional; Region: PRK12704
863767004474	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
863767004475	Zn2+ binding site [ion binding]; other site
863767004476	Mg2+ binding site [ion binding]; other site
863767004477	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
863767004478	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767004479	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
863767004480	Coenzyme A binding pocket [chemical binding]; other site
863767004481	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
863767004482	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
863767004483	putative active site [active]
863767004484	metal binding site [ion binding]; metal-binding site
863767004485	homodimer binding site [polypeptide binding]; other site
863767004486	Predicted membrane protein [Function unknown]; Region: COG4550
863767004487	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
863767004488	MutS domain I; Region: MutS_I; pfam01624
863767004489	MutS domain II; Region: MutS_II; pfam05188
863767004490	MutS domain III; Region: MutS_III; pfam05192
863767004491	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
863767004492	Walker A/P-loop; other site
863767004493	ATP binding site [chemical binding]; other site
863767004494	Q-loop/lid; other site
863767004495	ABC transporter signature motif; other site
863767004496	Walker B; other site
863767004497	D-loop; other site
863767004498	H-loop/switch region; other site
863767004499	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
863767004500	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767004501	ATP binding site [chemical binding]; other site
863767004502	Mg2+ binding site [ion binding]; other site
863767004503	G-X-G motif; other site
863767004504	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
863767004505	ATP binding site [chemical binding]; other site
863767004506	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
863767004507	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
863767004508	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
863767004509	Pyruvate formate lyase 1; Region: PFL1; cd01678
863767004510	coenzyme A binding site [chemical binding]; other site
863767004511	active site
863767004512	catalytic residues [active]
863767004513	glycine loop; other site
863767004514	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
863767004515	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
863767004516	FeS/SAM binding site; other site
863767004517	Predicted transcriptional regulators [Transcription]; Region: COG1695
863767004518	Transcriptional regulator PadR-like family; Region: PadR; cl17335
863767004519	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
863767004520	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767004521	Major Facilitator Superfamily; Region: MFS_1; pfam07690
863767004522	putative substrate translocation pore; other site
863767004523	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767004524	non-specific DNA binding site [nucleotide binding]; other site
863767004525	salt bridge; other site
863767004526	sequence-specific DNA binding site [nucleotide binding]; other site
863767004527	hypothetical protein; Provisional; Region: PRK06547
863767004528	topology modulation protein; Reviewed; Region: PRK08118
863767004529	AAA domain; Region: AAA_17; pfam13207
863767004530	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767004531	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767004532	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767004533	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767004534	putative acyltransferase; Provisional; Region: PRK05790
863767004535	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
863767004536	dimer interface [polypeptide binding]; other site
863767004537	active site
863767004538	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
863767004539	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
863767004540	dimer interface [polypeptide binding]; other site
863767004541	active site
863767004542	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
863767004543	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
863767004544	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767004545	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
863767004546	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
863767004547	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
863767004548	Domain of unknown function DUF20; Region: UPF0118; pfam01594
863767004549	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
863767004550	FAD binding domain; Region: FAD_binding_4; pfam01565
863767004551	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
863767004552	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
863767004553	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
863767004554	Walker A/P-loop; other site
863767004555	ATP binding site [chemical binding]; other site
863767004556	Q-loop/lid; other site
863767004557	ABC transporter signature motif; other site
863767004558	Walker B; other site
863767004559	D-loop; other site
863767004560	H-loop/switch region; other site
863767004561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767004562	dimer interface [polypeptide binding]; other site
863767004563	conserved gate region; other site
863767004564	ABC-ATPase subunit interface; other site
863767004565	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
863767004566	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
863767004567	manganese transport protein MntH; Reviewed; Region: PRK00701
863767004568	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
863767004569	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767004570	dimer interface [polypeptide binding]; other site
863767004571	conserved gate region; other site
863767004572	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
863767004573	ABC-ATPase subunit interface; other site
863767004574	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
863767004575	LysR substrate binding domain; Region: LysR_substrate; pfam03466
863767004576	dimerization interface [polypeptide binding]; other site
863767004577	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767004578	dimer interface [polypeptide binding]; other site
863767004579	conserved gate region; other site
863767004580	putative PBP binding loops; other site
863767004581	ABC-ATPase subunit interface; other site
863767004582	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
863767004583	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
863767004584	Walker A/P-loop; other site
863767004585	ATP binding site [chemical binding]; other site
863767004586	Q-loop/lid; other site
863767004587	ABC transporter signature motif; other site
863767004588	Walker B; other site
863767004589	D-loop; other site
863767004590	H-loop/switch region; other site
863767004591	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
863767004592	Predicted membrane protein [Function unknown]; Region: COG3859
863767004593	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
863767004594	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
863767004595	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
863767004596	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
863767004597	ABC transporter; Region: ABC_tran_2; pfam12848
863767004598	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
863767004599	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
863767004600	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
863767004601	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
863767004602	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
863767004603	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
863767004604	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
863767004605	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
863767004606	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
863767004607	dihydrodipicolinate synthase; Region: dapA; TIGR00674
863767004608	dimer interface [polypeptide binding]; other site
863767004609	active site
863767004610	catalytic residue [active]
863767004611	aspartate kinase I; Reviewed; Region: PRK08210
863767004612	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
863767004613	nucleotide binding site [chemical binding]; other site
863767004614	substrate binding site [chemical binding]; other site
863767004615	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
863767004616	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
863767004617	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
863767004618	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
863767004619	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
863767004620	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
863767004621	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
863767004622	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
863767004623	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
863767004624	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
863767004625	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
863767004626	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
863767004627	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
863767004628	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
863767004629	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
863767004630	Predicted membrane protein [Function unknown]; Region: COG4392
863767004631	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
863767004632	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
863767004633	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
863767004634	metal binding site 2 [ion binding]; metal-binding site
863767004635	putative DNA binding helix; other site
863767004636	metal binding site 1 [ion binding]; metal-binding site
863767004637	dimer interface [polypeptide binding]; other site
863767004638	structural Zn2+ binding site [ion binding]; other site
863767004639	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
863767004640	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
863767004641	ABC-ATPase subunit  interface; other site
863767004642	dimer interface [polypeptide binding]; other site
863767004643	putative PBP binding regions; other site
863767004644	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
863767004645	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
863767004646	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
863767004647	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
863767004648	DHHA2 domain; Region: DHHA2; pfam02833
863767004649	endonuclease IV; Provisional; Region: PRK01060
863767004650	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
863767004651	AP (apurinic/apyrimidinic) site pocket; other site
863767004652	DNA interaction; other site
863767004653	Metal-binding active site; metal-binding site
863767004654	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
863767004655	DEAD-like helicases superfamily; Region: DEXDc; smart00487
863767004656	ATP binding site [chemical binding]; other site
863767004657	Mg++ binding site [ion binding]; other site
863767004658	motif III; other site
863767004659	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
863767004660	nucleotide binding region [chemical binding]; other site
863767004661	ATP-binding site [chemical binding]; other site
863767004662	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
863767004663	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
863767004664	Uncharacterized conserved protein [Function unknown]; Region: COG0327
863767004665	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
863767004666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
863767004667	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
863767004668	Uncharacterized conserved protein [Function unknown]; Region: COG0327
863767004669	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
863767004670	Family of unknown function (DUF633); Region: DUF633; pfam04816
863767004671	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
863767004672	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
863767004673	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
863767004674	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
863767004675	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
863767004676	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
863767004677	DNA binding residues [nucleotide binding]
863767004678	DNA primase; Validated; Region: dnaG; PRK05667
863767004679	CHC2 zinc finger; Region: zf-CHC2; pfam01807
863767004680	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
863767004681	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
863767004682	active site
863767004683	metal binding site [ion binding]; metal-binding site
863767004684	interdomain interaction site; other site
863767004685	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
863767004686	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
863767004687	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
863767004688	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
863767004689	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
863767004690	DALR anticodon binding domain; Region: DALR_1; pfam05746
863767004691	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
863767004692	dimer interface [polypeptide binding]; other site
863767004693	motif 1; other site
863767004694	active site
863767004695	motif 2; other site
863767004696	motif 3; other site
863767004697	DNA repair protein RecO; Region: reco; TIGR00613
863767004698	Recombination protein O N terminal; Region: RecO_N; pfam11967
863767004699	Recombination protein O C terminal; Region: RecO_C; pfam02565
863767004700	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
863767004701	GTPase Era; Reviewed; Region: era; PRK00089
863767004702	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
863767004703	G1 box; other site
863767004704	GTP/Mg2+ binding site [chemical binding]; other site
863767004705	Switch I region; other site
863767004706	G2 box; other site
863767004707	Switch II region; other site
863767004708	G3 box; other site
863767004709	G4 box; other site
863767004710	G5 box; other site
863767004711	KH domain; Region: KH_2; pfam07650
863767004712	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
863767004713	active site
863767004714	catalytic motif [active]
863767004715	Zn binding site [ion binding]; other site
863767004716	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
863767004717	metal-binding heat shock protein; Provisional; Region: PRK00016
863767004718	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
863767004719	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
863767004720	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
863767004721	Zn2+ binding site [ion binding]; other site
863767004722	Mg2+ binding site [ion binding]; other site
863767004723	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
863767004724	PhoH-like protein; Region: PhoH; pfam02562
863767004725	Yqey-like protein; Region: YqeY; pfam09424
863767004726	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
863767004727	RNA methyltransferase, RsmE family; Region: TIGR00046
863767004728	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
863767004729	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
863767004730	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767004731	S-adenosylmethionine binding site [chemical binding]; other site
863767004732	chaperone protein DnaJ; Provisional; Region: PRK14280
863767004733	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
863767004734	HSP70 interaction site [polypeptide binding]; other site
863767004735	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
863767004736	substrate binding site [polypeptide binding]; other site
863767004737	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
863767004738	Zn binding sites [ion binding]; other site
863767004739	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
863767004740	dimer interface [polypeptide binding]; other site
863767004741	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
863767004742	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
863767004743	nucleotide binding site [chemical binding]; other site
863767004744	NEF interaction site [polypeptide binding]; other site
863767004745	SBD interface [polypeptide binding]; other site
863767004746	heat shock protein GrpE; Provisional; Region: PRK14140
863767004747	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
863767004748	dimer interface [polypeptide binding]; other site
863767004749	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
863767004750	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
863767004751	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
863767004752	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
863767004753	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
863767004754	FeS/SAM binding site; other site
863767004755	HemN C-terminal domain; Region: HemN_C; pfam06969
863767004756	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
863767004757	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
863767004758	NADP binding site [chemical binding]; other site
863767004759	putative substrate binding site [chemical binding]; other site
863767004760	active site
863767004761	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
863767004762	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
863767004763	DNA binding residues [nucleotide binding]
863767004764	putative dimer interface [polypeptide binding]; other site
863767004765	GTP-binding protein LepA; Provisional; Region: PRK05433
863767004766	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
863767004767	G1 box; other site
863767004768	putative GEF interaction site [polypeptide binding]; other site
863767004769	GTP/Mg2+ binding site [chemical binding]; other site
863767004770	Switch I region; other site
863767004771	G2 box; other site
863767004772	G3 box; other site
863767004773	Switch II region; other site
863767004774	G4 box; other site
863767004775	G5 box; other site
863767004776	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
863767004777	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
863767004778	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
863767004779	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
863767004780	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
863767004781	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
863767004782	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
863767004783	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
863767004784	Competence protein; Region: Competence; pfam03772
863767004785	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
863767004786	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
863767004787	catalytic motif [active]
863767004788	Zn binding site [ion binding]; other site
863767004789	SLBB domain; Region: SLBB; pfam10531
863767004790	comEA protein; Region: comE; TIGR01259
863767004791	Helix-hairpin-helix motif; Region: HHH; pfam00633
863767004792	Methyltransferase domain; Region: Methyltransf_23; pfam13489
863767004793	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767004794	S-adenosylmethionine binding site [chemical binding]; other site
863767004795	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
863767004796	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
863767004797	Zn2+ binding site [ion binding]; other site
863767004798	Mg2+ binding site [ion binding]; other site
863767004799	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
863767004800	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
863767004801	active site
863767004802	(T/H)XGH motif; other site
863767004803	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
863767004804	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
863767004805	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
863767004806	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
863767004807	shikimate binding site; other site
863767004808	NAD(P) binding site [chemical binding]; other site
863767004809	GTPase YqeH; Provisional; Region: PRK13796
863767004810	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
863767004811	GTP/Mg2+ binding site [chemical binding]; other site
863767004812	G4 box; other site
863767004813	G5 box; other site
863767004814	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
863767004815	G1 box; other site
863767004816	G1 box; other site
863767004817	GTP/Mg2+ binding site [chemical binding]; other site
863767004818	G2 box; other site
863767004819	Switch I region; other site
863767004820	G2 box; other site
863767004821	Switch I region; other site
863767004822	G3 box; other site
863767004823	G3 box; other site
863767004824	Switch II region; other site
863767004825	Switch II region; other site
863767004826	G4 box; other site
863767004827	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
863767004828	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767004829	motif II; other site
863767004830	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
863767004831	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
863767004832	active site
863767004833	Zn binding site [ion binding]; other site
863767004834	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
863767004835	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
863767004836	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
863767004837	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
863767004838	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
863767004839	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
863767004840	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
863767004841	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
863767004842	Sugar specificity; other site
863767004843	Pyrimidine base specificity; other site
863767004844	ATP-binding site [chemical binding]; other site
863767004845	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
863767004846	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767004847	S-adenosylmethionine binding site [chemical binding]; other site
863767004848	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
863767004849	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
863767004850	dimerization interface [polypeptide binding]; other site
863767004851	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
863767004852	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
863767004853	hypothetical protein; Provisional; Region: PRK13678
863767004854	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
863767004855	hypothetical protein; Provisional; Region: PRK05473
863767004856	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
863767004857	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
863767004858	motif 1; other site
863767004859	active site
863767004860	motif 2; other site
863767004861	motif 3; other site
863767004862	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
863767004863	DHHA1 domain; Region: DHHA1; pfam02272
863767004864	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
863767004865	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
863767004866	Walker A/P-loop; other site
863767004867	ATP binding site [chemical binding]; other site
863767004868	Q-loop/lid; other site
863767004869	ABC transporter signature motif; other site
863767004870	Walker B; other site
863767004871	D-loop; other site
863767004872	H-loop/switch region; other site
863767004873	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
863767004874	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
863767004875	FtsX-like permease family; Region: FtsX; pfam02687
863767004876	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
863767004877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767004878	active site
863767004879	phosphorylation site [posttranslational modification]
863767004880	intermolecular recognition site; other site
863767004881	dimerization interface [polypeptide binding]; other site
863767004882	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
863767004883	DNA binding site [nucleotide binding]
863767004884	sensor kinase CusS; Provisional; Region: PRK09835
863767004885	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
863767004886	dimerization interface [polypeptide binding]; other site
863767004887	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
863767004888	dimer interface [polypeptide binding]; other site
863767004889	phosphorylation site [posttranslational modification]
863767004890	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767004891	ATP binding site [chemical binding]; other site
863767004892	Mg2+ binding site [ion binding]; other site
863767004893	G-X-G motif; other site
863767004894	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
863767004895	AAA domain; Region: AAA_30; pfam13604
863767004896	Family description; Region: UvrD_C_2; pfam13538
863767004897	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
863767004898	binding surface
863767004899	TPR motif; other site
863767004900	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
863767004901	TPR repeat; Region: TPR_11; pfam13414
863767004902	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
863767004903	binding surface
863767004904	TPR motif; other site
863767004905	TPR repeat; Region: TPR_11; pfam13414
863767004906	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
863767004907	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
863767004908	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
863767004909	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
863767004910	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
863767004911	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
863767004912	catalytic residue [active]
863767004913	recombination factor protein RarA; Reviewed; Region: PRK13342
863767004914	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767004915	Walker A motif; other site
863767004916	ATP binding site [chemical binding]; other site
863767004917	Walker B motif; other site
863767004918	arginine finger; other site
863767004919	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
863767004920	Predicted transcriptional regulator [Transcription]; Region: COG1959
863767004921	Transcriptional regulator; Region: Rrf2; pfam02082
863767004922	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
863767004923	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
863767004924	Nitrogen regulatory protein P-II; Region: P-II; smart00938
863767004925	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
863767004926	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
863767004927	dimer interface [polypeptide binding]; other site
863767004928	anticodon binding site; other site
863767004929	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
863767004930	homodimer interface [polypeptide binding]; other site
863767004931	motif 1; other site
863767004932	active site
863767004933	motif 2; other site
863767004934	GAD domain; Region: GAD; pfam02938
863767004935	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
863767004936	motif 3; other site
863767004937	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
863767004938	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
863767004939	dimer interface [polypeptide binding]; other site
863767004940	motif 1; other site
863767004941	active site
863767004942	motif 2; other site
863767004943	motif 3; other site
863767004944	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
863767004945	anticodon binding site; other site
863767004946	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
863767004947	Bacterial SH3 domain; Region: SH3_3; pfam08239
863767004948	Bacterial SH3 domain; Region: SH3_3; pfam08239
863767004949	Bacterial SH3 domain homologues; Region: SH3b; smart00287
863767004950	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
863767004951	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
863767004952	active site
863767004953	metal binding site [ion binding]; metal-binding site
863767004954	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
863767004955	putative active site [active]
863767004956	dimerization interface [polypeptide binding]; other site
863767004957	putative tRNAtyr binding site [nucleotide binding]; other site
863767004958	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
863767004959	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
863767004960	Zn2+ binding site [ion binding]; other site
863767004961	Mg2+ binding site [ion binding]; other site
863767004962	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
863767004963	synthetase active site [active]
863767004964	NTP binding site [chemical binding]; other site
863767004965	metal binding site [ion binding]; metal-binding site
863767004966	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
863767004967	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
863767004968	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
863767004969	active site
863767004970	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
863767004971	DHH family; Region: DHH; pfam01368
863767004972	DHHA1 domain; Region: DHHA1; pfam02272
863767004973	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
863767004974	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
863767004975	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
863767004976	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
863767004977	Protein export membrane protein; Region: SecD_SecF; cl14618
863767004978	Protein export membrane protein; Region: SecD_SecF; pfam02355
863767004979	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
863767004980	Preprotein translocase subunit; Region: YajC; pfam02699
863767004981	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
863767004982	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
863767004983	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
863767004984	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
863767004985	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
863767004986	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767004987	Walker A motif; other site
863767004988	ATP binding site [chemical binding]; other site
863767004989	Walker B motif; other site
863767004990	arginine finger; other site
863767004991	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
863767004992	Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
863767004993	RuvA N terminal domain; Region: RuvA_N; pfam01330
863767004994	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
863767004995	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
863767004996	tetramer (dimer of dimers) interface [polypeptide binding]; other site
863767004997	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
863767004998	NAD binding site [chemical binding]; other site
863767004999	dimer interface [polypeptide binding]; other site
863767005000	substrate binding site [chemical binding]; other site
863767005001	hypothetical protein; Validated; Region: PRK00110
863767005002	prephenate dehydratase; Provisional; Region: PRK11898
863767005003	Prephenate dehydratase; Region: PDT; pfam00800
863767005004	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
863767005005	putative L-Phe binding site [chemical binding]; other site
863767005006	GTPase CgtA; Reviewed; Region: obgE; PRK12297
863767005007	GTP1/OBG; Region: GTP1_OBG; pfam01018
863767005008	Obg GTPase; Region: Obg; cd01898
863767005009	G1 box; other site
863767005010	GTP/Mg2+ binding site [chemical binding]; other site
863767005011	Switch I region; other site
863767005012	G2 box; other site
863767005013	G3 box; other site
863767005014	Switch II region; other site
863767005015	G4 box; other site
863767005016	G5 box; other site
863767005017	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
863767005018	glycerol kinase; Provisional; Region: glpK; PRK00047
863767005019	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
863767005020	N- and C-terminal domain interface [polypeptide binding]; other site
863767005021	active site
863767005022	MgATP binding site [chemical binding]; other site
863767005023	catalytic site [active]
863767005024	metal binding site [ion binding]; metal-binding site
863767005025	glycerol binding site [chemical binding]; other site
863767005026	homotetramer interface [polypeptide binding]; other site
863767005027	homodimer interface [polypeptide binding]; other site
863767005028	FBP binding site [chemical binding]; other site
863767005029	protein IIAGlc interface [polypeptide binding]; other site
863767005030	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
863767005031	amphipathic channel; other site
863767005032	Asn-Pro-Ala signature motifs; other site
863767005033	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
863767005034	hypothetical protein; Provisional; Region: PRK14553
863767005035	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
863767005036	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
863767005037	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
863767005038	homodimer interface [polypeptide binding]; other site
863767005039	oligonucleotide binding site [chemical binding]; other site
863767005040	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
863767005041	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
863767005042	Switch I; other site
863767005043	Switch II; other site
863767005044	septum formation inhibitor; Reviewed; Region: minC; PRK00513
863767005045	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
863767005046	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
863767005047	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
863767005048	Protein of unknown function (DUF972); Region: DUF972; pfam06156
863767005049	rod shape-determining protein MreC; Region: MreC; pfam04085
863767005050	rod shape-determining protein MreB; Provisional; Region: PRK13927
863767005051	MreB and similar proteins; Region: MreB_like; cd10225
863767005052	nucleotide binding site [chemical binding]; other site
863767005053	Mg binding site [ion binding]; other site
863767005054	putative protofilament interaction site [polypeptide binding]; other site
863767005055	RodZ interaction site [polypeptide binding]; other site
863767005056	hypothetical protein; Reviewed; Region: PRK00024
863767005057	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
863767005058	MPN+ (JAMM) motif; other site
863767005059	Zinc-binding site [ion binding]; other site
863767005060	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
863767005061	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
863767005062	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
863767005063	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
863767005064	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
863767005065	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
863767005066	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
863767005067	active site
863767005068	HIGH motif; other site
863767005069	nucleotide binding site [chemical binding]; other site
863767005070	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
863767005071	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
863767005072	active site
863767005073	KMSKS motif; other site
863767005074	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
863767005075	tRNA binding surface [nucleotide binding]; other site
863767005076	anticodon binding site; other site
863767005077	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
863767005078	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
863767005079	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
863767005080	inhibitor-cofactor binding pocket; inhibition site
863767005081	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767005082	catalytic residue [active]
863767005083	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
863767005084	dimer interface [polypeptide binding]; other site
863767005085	active site
863767005086	Schiff base residues; other site
863767005087	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
863767005088	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
863767005089	active site
863767005090	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
863767005091	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
863767005092	domain interfaces; other site
863767005093	active site
863767005094	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
863767005095	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
863767005096	tRNA; other site
863767005097	putative tRNA binding site [nucleotide binding]; other site
863767005098	putative NADP binding site [chemical binding]; other site
863767005099	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
863767005100	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
863767005101	G1 box; other site
863767005102	GTP/Mg2+ binding site [chemical binding]; other site
863767005103	Switch I region; other site
863767005104	G2 box; other site
863767005105	G3 box; other site
863767005106	Switch II region; other site
863767005107	G4 box; other site
863767005108	G5 box; other site
863767005109	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
863767005110	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
863767005111	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
863767005112	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
863767005113	active site
863767005114	dimer interface [polypeptide binding]; other site
863767005115	motif 1; other site
863767005116	motif 2; other site
863767005117	motif 3; other site
863767005118	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
863767005119	anticodon binding site; other site
863767005120	primosomal protein DnaI; Reviewed; Region: PRK08939
863767005121	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
863767005122	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
863767005123	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
863767005124	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
863767005125	ATP cone domain; Region: ATP-cone; pfam03477
863767005126	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
863767005127	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
863767005128	CoA-binding site [chemical binding]; other site
863767005129	ATP-binding [chemical binding]; other site
863767005130	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
863767005131	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
863767005132	DNA binding site [nucleotide binding]
863767005133	catalytic residue [active]
863767005134	H2TH interface [polypeptide binding]; other site
863767005135	putative catalytic residues [active]
863767005136	turnover-facilitating residue; other site
863767005137	intercalation triad [nucleotide binding]; other site
863767005138	8OG recognition residue [nucleotide binding]; other site
863767005139	putative reading head residues; other site
863767005140	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
863767005141	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
863767005142	DNA polymerase I; Provisional; Region: PRK05755
863767005143	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
863767005144	active site
863767005145	metal binding site 1 [ion binding]; metal-binding site
863767005146	putative 5' ssDNA interaction site; other site
863767005147	metal binding site 3; metal-binding site
863767005148	metal binding site 2 [ion binding]; metal-binding site
863767005149	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
863767005150	putative DNA binding site [nucleotide binding]; other site
863767005151	putative metal binding site [ion binding]; other site
863767005152	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
863767005153	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
863767005154	active site
863767005155	DNA binding site [nucleotide binding]
863767005156	catalytic site [active]
863767005157	isocitrate dehydrogenase; Reviewed; Region: PRK07006
863767005158	isocitrate dehydrogenase; Validated; Region: PRK07362
863767005159	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
863767005160	dimer interface [polypeptide binding]; other site
863767005161	Citrate synthase; Region: Citrate_synt; pfam00285
863767005162	active site
863767005163	citrylCoA binding site [chemical binding]; other site
863767005164	oxalacetate/citrate binding site [chemical binding]; other site
863767005165	coenzyme A binding site [chemical binding]; other site
863767005166	catalytic triad [active]
863767005167	Protein of unknown function (DUF441); Region: DUF441; pfam04284
863767005168	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
863767005169	pyruvate kinase; Provisional; Region: PRK06354
863767005170	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
863767005171	domain interfaces; other site
863767005172	active site
863767005173	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
863767005174	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
863767005175	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
863767005176	active site
863767005177	ADP/pyrophosphate binding site [chemical binding]; other site
863767005178	dimerization interface [polypeptide binding]; other site
863767005179	allosteric effector site; other site
863767005180	fructose-1,6-bisphosphate binding site; other site
863767005181	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
863767005182	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
863767005183	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
863767005184	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
863767005185	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
863767005186	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
863767005187	active site
863767005188	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
863767005189	generic binding surface I; other site
863767005190	generic binding surface II; other site
863767005191	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
863767005192	DHH family; Region: DHH; pfam01368
863767005193	DHHA1 domain; Region: DHHA1; pfam02272
863767005194	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
863767005195	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
863767005196	DNA-binding site [nucleotide binding]; DNA binding site
863767005197	DRTGG domain; Region: DRTGG; pfam07085
863767005198	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
863767005199	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
863767005200	active site 2 [active]
863767005201	active site 1 [active]
863767005202	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
863767005203	metal-dependent hydrolase; Provisional; Region: PRK00685
863767005204	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
863767005205	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
863767005206	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
863767005207	active site
863767005208	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
863767005209	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
863767005210	hexamer interface [polypeptide binding]; other site
863767005211	ligand binding site [chemical binding]; other site
863767005212	putative active site [active]
863767005213	NAD(P) binding site [chemical binding]; other site
863767005214	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
863767005215	Ligand Binding Site [chemical binding]; other site
863767005216	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
863767005217	propionate/acetate kinase; Provisional; Region: PRK12379
863767005218	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
863767005219	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767005220	S-adenosylmethionine binding site [chemical binding]; other site
863767005221	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
863767005222	dimer interface [polypeptide binding]; other site
863767005223	catalytic triad [active]
863767005224	peroxidatic and resolving cysteines [active]
863767005225	RDD family; Region: RDD; pfam06271
863767005226	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
863767005227	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
863767005228	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
863767005229	tandem repeat interface [polypeptide binding]; other site
863767005230	active site residues [active]
863767005231	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
863767005232	ATP-NAD kinase; Region: NAD_kinase; pfam01513
863767005233	ornithine carbamoyltransferase; Provisional; Region: PRK00779
863767005234	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
863767005235	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
863767005236	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
863767005237	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
863767005238	catalytic residue [active]
863767005239	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
863767005240	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
863767005241	nucleotide binding site [chemical binding]; other site
863767005242	N-acetyl-L-glutamate binding site [chemical binding]; other site
863767005243	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
863767005244	heterotetramer interface [polypeptide binding]; other site
863767005245	active site pocket [active]
863767005246	cleavage site
863767005247	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
863767005248	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
863767005249	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
863767005250	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
863767005251	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
863767005252	Ligand Binding Site [chemical binding]; other site
863767005253	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
863767005254	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
863767005255	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
863767005256	catalytic residue [active]
863767005257	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
863767005258	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
863767005259	GAF domain; Region: GAF_2; pfam13185
863767005260	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
863767005261	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
863767005262	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
863767005263	RNA binding surface [nucleotide binding]; other site
863767005264	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
863767005265	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
863767005266	active site
863767005267	HIGH motif; other site
863767005268	dimer interface [polypeptide binding]; other site
863767005269	KMSKS motif; other site
863767005270	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
863767005271	RNA binding surface [nucleotide binding]; other site
863767005272	catabolite control protein A; Region: ccpA; TIGR01481
863767005273	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
863767005274	DNA binding site [nucleotide binding]
863767005275	domain linker motif; other site
863767005276	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
863767005277	dimerization interface [polypeptide binding]; other site
863767005278	effector binding site; other site
863767005279	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
863767005280	Chorismate mutase type II; Region: CM_2; cl00693
863767005281	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
863767005282	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
863767005283	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
863767005284	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
863767005285	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
863767005286	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
863767005287	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
863767005288	dimer interface [polypeptide binding]; other site
863767005289	decamer (pentamer of dimers) interface [polypeptide binding]; other site
863767005290	catalytic triad [active]
863767005291	peroxidatic and resolving cysteines [active]
863767005292	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
863767005293	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
863767005294	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
863767005295	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
863767005296	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
863767005297	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
863767005298	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
863767005299	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
863767005300	putative tRNA-binding site [nucleotide binding]; other site
863767005301	hypothetical protein; Provisional; Region: PRK13668
863767005302	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
863767005303	catalytic residues [active]
863767005304	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
863767005305	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
863767005306	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
863767005307	oligomer interface [polypeptide binding]; other site
863767005308	active site
863767005309	metal binding site [ion binding]; metal-binding site
863767005310	Predicted small secreted protein [Function unknown]; Region: COG5584
863767005311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937
863767005312	putative homodimer interface [polypeptide binding]; other site
863767005313	putative homotetramer interface [polypeptide binding]; other site
863767005314	putative allosteric switch controlling residues; other site
863767005315	putative metal binding site [ion binding]; other site
863767005316	putative homodimer-homodimer interface [polypeptide binding]; other site
863767005317	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
863767005318	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767005319	S-adenosylmethionine binding site [chemical binding]; other site
863767005320	Phosphotransferase enzyme family; Region: APH; pfam01636
863767005321	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
863767005322	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
863767005323	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767005324	putative substrate translocation pore; other site
863767005325	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767005326	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
863767005327	MarR family; Region: MarR; pfam01047
863767005328	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
863767005329	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
863767005330	homodimer interface [polypeptide binding]; other site
863767005331	substrate-cofactor binding pocket; other site
863767005332	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767005333	catalytic residue [active]
863767005334	dipeptidase PepV; Reviewed; Region: PRK07318
863767005335	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
863767005336	active site
863767005337	metal binding site [ion binding]; metal-binding site
863767005338	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699
863767005339	nudix motif; other site
863767005340	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
863767005341	putative substrate binding site [chemical binding]; other site
863767005342	putative ATP binding site [chemical binding]; other site
863767005343	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
863767005344	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
863767005345	active site
863767005346	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
863767005347	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
863767005348	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
863767005349	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
863767005350	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
863767005351	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
863767005352	substrate binding site [chemical binding]; other site
863767005353	active site
863767005354	catalytic residues [active]
863767005355	heterodimer interface [polypeptide binding]; other site
863767005356	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
863767005357	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
863767005358	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767005359	catalytic residue [active]
863767005360	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
863767005361	active site
863767005362	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
863767005363	active site
863767005364	ribulose/triose binding site [chemical binding]; other site
863767005365	phosphate binding site [ion binding]; other site
863767005366	substrate (anthranilate) binding pocket [chemical binding]; other site
863767005367	product (indole) binding pocket [chemical binding]; other site
863767005368	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
863767005369	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
863767005370	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
863767005371	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
863767005372	Glutamine amidotransferase class-I; Region: GATase; pfam00117
863767005373	glutamine binding [chemical binding]; other site
863767005374	catalytic triad [active]
863767005375	anthranilate synthase component I; Provisional; Region: PRK13570
863767005376	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
863767005377	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
863767005378	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
863767005379	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
863767005380	putative catalytic cysteine [active]
863767005381	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
863767005382	putative active site [active]
863767005383	metal binding site [ion binding]; metal-binding site
863767005384	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
863767005385	dimer interface [polypeptide binding]; other site
863767005386	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
863767005387	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767005388	Walker A/P-loop; other site
863767005389	ATP binding site [chemical binding]; other site
863767005390	Q-loop/lid; other site
863767005391	ABC transporter signature motif; other site
863767005392	Walker B; other site
863767005393	D-loop; other site
863767005394	H-loop/switch region; other site
863767005395	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
863767005396	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
863767005397	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
863767005398	putative dimer interface [polypeptide binding]; other site
863767005399	catalytic triad [active]
863767005400	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
863767005401	aconitate hydratase; Validated; Region: PRK09277
863767005402	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
863767005403	substrate binding site [chemical binding]; other site
863767005404	ligand binding site [chemical binding]; other site
863767005405	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
863767005406	substrate binding site [chemical binding]; other site
863767005407	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
863767005408	Heat induced stress protein YflT; Region: YflT; pfam11181
863767005409	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
863767005410	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
863767005411	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
863767005412	ATP binding site [chemical binding]; other site
863767005413	putative Mg++ binding site [ion binding]; other site
863767005414	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
863767005415	nucleotide binding region [chemical binding]; other site
863767005416	ATP-binding site [chemical binding]; other site
863767005417	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
863767005418	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
863767005419	Walker A/P-loop; other site
863767005420	ATP binding site [chemical binding]; other site
863767005421	Q-loop/lid; other site
863767005422	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
863767005423	ABC transporter signature motif; other site
863767005424	Walker B; other site
863767005425	D-loop; other site
863767005426	H-loop/switch region; other site
863767005427	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
863767005428	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
863767005429	active site
863767005430	metal binding site [ion binding]; metal-binding site
863767005431	DNA binding site [nucleotide binding]
863767005432	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
863767005433	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
863767005434	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
863767005435	putative acyl-acceptor binding pocket; other site
863767005436	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
863767005437	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
863767005438	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
863767005439	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
863767005440	Walker A/P-loop; other site
863767005441	ATP binding site [chemical binding]; other site
863767005442	Q-loop/lid; other site
863767005443	ABC transporter signature motif; other site
863767005444	Walker B; other site
863767005445	D-loop; other site
863767005446	H-loop/switch region; other site
863767005447	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
863767005448	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
863767005449	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767005450	Walker A/P-loop; other site
863767005451	ATP binding site [chemical binding]; other site
863767005452	Q-loop/lid; other site
863767005453	ABC transporter signature motif; other site
863767005454	Walker B; other site
863767005455	D-loop; other site
863767005456	H-loop/switch region; other site
863767005457	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
863767005458	active site
863767005459	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
863767005460	elongation factor Ts; Provisional; Region: tsf; PRK09377
863767005461	UBA/TS-N domain; Region: UBA; pfam00627
863767005462	Elongation factor TS; Region: EF_TS; pfam00889
863767005463	Elongation factor TS; Region: EF_TS; pfam00889
863767005464	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
863767005465	rRNA interaction site [nucleotide binding]; other site
863767005466	S8 interaction site; other site
863767005467	putative laminin-1 binding site; other site
863767005468	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
863767005469	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
863767005470	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
863767005471	active site turn [active]
863767005472	phosphorylation site [posttranslational modification]
863767005473	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
863767005474	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
863767005475	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
863767005476	putative active site [active]
863767005477	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
863767005478	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
863767005479	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
863767005480	putative active site [active]
863767005481	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
863767005482	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
863767005483	HIGH motif; other site
863767005484	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
863767005485	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
863767005486	active site
863767005487	KMSKS motif; other site
863767005488	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
863767005489	tRNA binding surface [nucleotide binding]; other site
863767005490	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
863767005491	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
863767005492	FeS/SAM binding site; other site
863767005493	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
863767005494	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
863767005495	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
863767005496	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
863767005497	active site
863767005498	dimer interface [polypeptide binding]; other site
863767005499	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
863767005500	Ligand Binding Site [chemical binding]; other site
863767005501	Molecular Tunnel; other site
863767005502	S-adenosylmethionine synthetase; Validated; Region: PRK05250
863767005503	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
863767005504	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
863767005505	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
863767005506	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
863767005507	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
863767005508	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
863767005509	tetramer (dimer of dimers) interface [polypeptide binding]; other site
863767005510	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
863767005511	NAD binding site [chemical binding]; other site
863767005512	dimer interface [polypeptide binding]; other site
863767005513	substrate binding site [chemical binding]; other site
863767005514	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
863767005515	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
863767005516	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
863767005517	nudix motif; other site
863767005518	Uncharacterized conserved protein [Function unknown]; Region: COG0759
863767005519	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
863767005520	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
863767005521	intersubunit interface [polypeptide binding]; other site
863767005522	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
863767005523	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
863767005524	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
863767005525	acyl-activating enzyme (AAE) consensus motif; other site
863767005526	putative AMP binding site [chemical binding]; other site
863767005527	putative active site [active]
863767005528	putative CoA binding site [chemical binding]; other site
863767005529	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
863767005530	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
863767005531	substrate binding site [chemical binding]; other site
863767005532	oxyanion hole (OAH) forming residues; other site
863767005533	trimer interface [polypeptide binding]; other site
863767005534	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
863767005535	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
863767005536	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
863767005537	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
863767005538	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
863767005539	dimer interface [polypeptide binding]; other site
863767005540	tetramer interface [polypeptide binding]; other site
863767005541	PYR/PP interface [polypeptide binding]; other site
863767005542	TPP binding site [chemical binding]; other site
863767005543	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
863767005544	TPP-binding site; other site
863767005545	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
863767005546	chorismate binding enzyme; Region: Chorismate_bind; cl10555
863767005547	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
863767005548	UbiA prenyltransferase family; Region: UbiA; pfam01040
863767005549	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
863767005550	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
863767005551	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
863767005552	FAD binding site [chemical binding]; other site
863767005553	cystathionine beta-lyase; Provisional; Region: PRK08064
863767005554	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
863767005555	homodimer interface [polypeptide binding]; other site
863767005556	substrate-cofactor binding pocket; other site
863767005557	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767005558	catalytic residue [active]
863767005559	cystathionine gamma-synthase; Reviewed; Region: PRK08247
863767005560	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
863767005561	homodimer interface [polypeptide binding]; other site
863767005562	substrate-cofactor binding pocket; other site
863767005563	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767005564	catalytic residue [active]
863767005565	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
863767005566	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
863767005567	THF binding site; other site
863767005568	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
863767005569	substrate binding site [chemical binding]; other site
863767005570	THF binding site; other site
863767005571	zinc-binding site [ion binding]; other site
863767005572	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767005573	Major Facilitator Superfamily; Region: MFS_1; pfam07690
863767005574	putative substrate translocation pore; other site
863767005575	ferric uptake regulator; Provisional; Region: fur; PRK09462
863767005576	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
863767005577	metal binding site 2 [ion binding]; metal-binding site
863767005578	putative DNA binding helix; other site
863767005579	metal binding site 1 [ion binding]; metal-binding site
863767005580	dimer interface [polypeptide binding]; other site
863767005581	structural Zn2+ binding site [ion binding]; other site
863767005582	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
863767005583	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
863767005584	NAD binding site [chemical binding]; other site
863767005585	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
863767005586	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
863767005587	inhibitor-cofactor binding pocket; inhibition site
863767005588	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767005589	catalytic residue [active]
863767005590	Predicted membrane protein [Function unknown]; Region: COG4129
863767005591	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
863767005592	hypothetical protein; Provisional; Region: PRK13662
863767005593	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
863767005594	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
863767005595	putative NAD(P) binding site [chemical binding]; other site
863767005596	active site
863767005597	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
863767005598	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
863767005599	minor groove reading motif; other site
863767005600	helix-hairpin-helix signature motif; other site
863767005601	substrate binding pocket [chemical binding]; other site
863767005602	active site
863767005603	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
863767005604	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
863767005605	DNA binding and oxoG recognition site [nucleotide binding]
863767005606	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
863767005607	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
863767005608	trimer interface [polypeptide binding]; other site
863767005609	active site
863767005610	WVELL protein; Region: WVELL; pfam14043
863767005611	recombination regulator RecX; Provisional; Region: recX; PRK14135
863767005612	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
863767005613	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
863767005614	NAD(P) binding site [chemical binding]; other site
863767005615	active site
863767005616	Predicted integral membrane protein [Function unknown]; Region: COG0392
863767005617	Uncharacterized conserved protein [Function unknown]; Region: COG2898
863767005618	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
863767005619	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
863767005620	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
863767005621	Cation efflux family; Region: Cation_efflux; pfam01545
863767005622	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
863767005623	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
863767005624	PAS fold; Region: PAS_4; pfam08448
863767005625	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
863767005626	putative active site [active]
863767005627	heme pocket [chemical binding]; other site
863767005628	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
863767005629	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
863767005630	dimer interface [polypeptide binding]; other site
863767005631	putative CheW interface [polypeptide binding]; other site
863767005632	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
863767005633	FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364
863767005634	dimer interface [polypeptide binding]; other site
863767005635	active site
863767005636	Mn binding site [ion binding]; other site
863767005637	TRAM domain; Region: TRAM; cl01282
863767005638	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
863767005639	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767005640	S-adenosylmethionine binding site [chemical binding]; other site
863767005641	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
863767005642	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
863767005643	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
863767005644	Substrate-binding site [chemical binding]; other site
863767005645	Substrate specificity [chemical binding]; other site
863767005646	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
863767005647	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840
863767005648	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
863767005649	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
863767005650	active site
863767005651	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
863767005652	flavodoxin, short chain; Region: flav_short; TIGR01753
863767005653	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
863767005654	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
863767005655	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767005656	Major Facilitator Superfamily; Region: MFS_1; pfam07690
863767005657	putative substrate translocation pore; other site
863767005658	rod-share determining protein MreBH; Provisional; Region: PRK13929
863767005659	MreB and similar proteins; Region: MreB_like; cd10225
863767005660	nucleotide binding site [chemical binding]; other site
863767005661	Mg binding site [ion binding]; other site
863767005662	putative protofilament interaction site [polypeptide binding]; other site
863767005663	RodZ interaction site [polypeptide binding]; other site
863767005664	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767005665	S-adenosylmethionine binding site [chemical binding]; other site
863767005666	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
863767005667	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
863767005668	Uncharacterized conserved protein [Function unknown]; Region: COG3589
863767005669	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
863767005670	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
863767005671	methionine cluster; other site
863767005672	active site
863767005673	phosphorylation site [posttranslational modification]
863767005674	metal binding site [ion binding]; metal-binding site
863767005675	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
863767005676	active site
863767005677	P-loop; other site
863767005678	phosphorylation site [posttranslational modification]
863767005679	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
863767005680	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
863767005681	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767005682	Walker A motif; other site
863767005683	ATP binding site [chemical binding]; other site
863767005684	Walker B motif; other site
863767005685	arginine finger; other site
863767005686	Transcriptional antiterminator [Transcription]; Region: COG3933
863767005687	PRD domain; Region: PRD; pfam00874
863767005688	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
863767005689	active pocket/dimerization site; other site
863767005690	active site
863767005691	phosphorylation site [posttranslational modification]
863767005692	PRD domain; Region: PRD; pfam00874
863767005693	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
863767005694	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
863767005695	nucleotide binding region [chemical binding]; other site
863767005696	ATP-binding site [chemical binding]; other site
863767005697	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
863767005698	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
863767005699	ATP binding site [chemical binding]; other site
863767005700	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
863767005701	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
863767005702	Transcriptional regulators [Transcription]; Region: PurR; COG1609
863767005703	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
863767005704	DNA binding site [nucleotide binding]
863767005705	domain linker motif; other site
863767005706	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
863767005707	dimerization interface [polypeptide binding]; other site
863767005708	ligand binding site [chemical binding]; other site
863767005709	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
863767005710	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
863767005711	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
863767005712	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
863767005713	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
863767005714	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
863767005715	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767005716	dimer interface [polypeptide binding]; other site
863767005717	conserved gate region; other site
863767005718	putative PBP binding loops; other site
863767005719	ABC-ATPase subunit interface; other site
863767005720	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
863767005721	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767005722	dimer interface [polypeptide binding]; other site
863767005723	conserved gate region; other site
863767005724	putative PBP binding loops; other site
863767005725	ABC-ATPase subunit interface; other site
863767005726	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
863767005727	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
863767005728	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
863767005729	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
863767005730	active site
863767005731	dimer interface [polypeptide binding]; other site
863767005732	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
863767005733	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
863767005734	active site
863767005735	FMN binding site [chemical binding]; other site
863767005736	substrate binding site [chemical binding]; other site
863767005737	3Fe-4S cluster binding site [ion binding]; other site
863767005738	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
863767005739	domain interface; other site
863767005740	Transcriptional regulator [Transcription]; Region: LysR; COG0583
863767005741	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
863767005742	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
863767005743	putative dimerization interface [polypeptide binding]; other site
863767005744	Predicted acetyltransferase [General function prediction only]; Region: COG3153
863767005745	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
863767005746	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
863767005747	putative active site [active]
863767005748	metal binding site [ion binding]; metal-binding site
863767005749	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
863767005750	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
863767005751	substrate binding pocket [chemical binding]; other site
863767005752	membrane-bound complex binding site; other site
863767005753	hinge residues; other site
863767005754	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
863767005755	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767005756	Walker A/P-loop; other site
863767005757	ATP binding site [chemical binding]; other site
863767005758	Q-loop/lid; other site
863767005759	ABC transporter signature motif; other site
863767005760	Walker B; other site
863767005761	D-loop; other site
863767005762	H-loop/switch region; other site
863767005763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767005764	dimer interface [polypeptide binding]; other site
863767005765	conserved gate region; other site
863767005766	putative PBP binding loops; other site
863767005767	ABC-ATPase subunit interface; other site
863767005768	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
863767005769	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
863767005770	dimer interface [polypeptide binding]; other site
863767005771	phosphorylation site [posttranslational modification]
863767005772	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767005773	ATP binding site [chemical binding]; other site
863767005774	Mg2+ binding site [ion binding]; other site
863767005775	G-X-G motif; other site
863767005776	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
863767005777	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
863767005778	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
863767005779	active site
863767005780	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
863767005781	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
863767005782	putative NAD(P) binding site [chemical binding]; other site
863767005783	active site
863767005784	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
863767005785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767005786	active site
863767005787	phosphorylation site [posttranslational modification]
863767005788	intermolecular recognition site; other site
863767005789	dimerization interface [polypeptide binding]; other site
863767005790	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
863767005791	DNA binding site [nucleotide binding]
863767005792	FtsX-like permease family; Region: FtsX; pfam02687
863767005793	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
863767005794	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
863767005795	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
863767005796	Walker A/P-loop; other site
863767005797	ATP binding site [chemical binding]; other site
863767005798	Q-loop/lid; other site
863767005799	ABC transporter signature motif; other site
863767005800	Walker B; other site
863767005801	D-loop; other site
863767005802	H-loop/switch region; other site
863767005803	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
863767005804	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
863767005805	ADP binding site [chemical binding]; other site
863767005806	magnesium binding site [ion binding]; other site
863767005807	putative shikimate binding site; other site
863767005808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884
863767005809	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
863767005810	TRAM domain; Region: TRAM; pfam01938
863767005811	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767005812	S-adenosylmethionine binding site [chemical binding]; other site
863767005813	putative lipid kinase; Reviewed; Region: PRK13337
863767005814	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
863767005815	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
863767005816	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
863767005817	GatB domain; Region: GatB_Yqey; smart00845
863767005818	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
863767005819	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
863767005820	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
863767005821	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
863767005822	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
863767005823	putative dimer interface [polypeptide binding]; other site
863767005824	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
863767005825	putative dimer interface [polypeptide binding]; other site
863767005826	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
863767005827	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
863767005828	nucleotide binding pocket [chemical binding]; other site
863767005829	K-X-D-G motif; other site
863767005830	catalytic site [active]
863767005831	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
863767005832	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
863767005833	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
863767005834	Dimer interface [polypeptide binding]; other site
863767005835	BRCT sequence motif; other site
863767005836	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
863767005837	Part of AAA domain; Region: AAA_19; pfam13245
863767005838	Family description; Region: UvrD_C_2; pfam13538
863767005839	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
863767005840	PcrB family; Region: PcrB; pfam01884
863767005841	substrate binding site [chemical binding]; other site
863767005842	putative active site [active]
863767005843	dimer interface [polypeptide binding]; other site
863767005844	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
863767005845	Na2 binding site [ion binding]; other site
863767005846	putative substrate binding site 1 [chemical binding]; other site
863767005847	Na binding site 1 [ion binding]; other site
863767005848	putative substrate binding site 2 [chemical binding]; other site
863767005849	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
863767005850	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
863767005851	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
863767005852	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
863767005853	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
863767005854	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
863767005855	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
863767005856	purine monophosphate binding site [chemical binding]; other site
863767005857	dimer interface [polypeptide binding]; other site
863767005858	putative catalytic residues [active]
863767005859	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
863767005860	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
863767005861	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
863767005862	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
863767005863	active site
863767005864	substrate binding site [chemical binding]; other site
863767005865	cosubstrate binding site; other site
863767005866	catalytic site [active]
863767005867	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
863767005868	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
863767005869	dimerization interface [polypeptide binding]; other site
863767005870	putative ATP binding site [chemical binding]; other site
863767005871	amidophosphoribosyltransferase; Provisional; Region: PRK06781
863767005872	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
863767005873	active site
863767005874	tetramer interface [polypeptide binding]; other site
863767005875	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
863767005876	active site
863767005877	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
863767005878	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
863767005879	dimerization interface [polypeptide binding]; other site
863767005880	ATP binding site [chemical binding]; other site
863767005881	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
863767005882	dimerization interface [polypeptide binding]; other site
863767005883	ATP binding site [chemical binding]; other site
863767005884	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
863767005885	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
863767005886	putative active site [active]
863767005887	catalytic triad [active]
863767005888	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
863767005889	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
863767005890	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
863767005891	ATP binding site [chemical binding]; other site
863767005892	active site
863767005893	substrate binding site [chemical binding]; other site
863767005894	adenylosuccinate lyase; Provisional; Region: PRK07492
863767005895	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
863767005896	tetramer interface [polypeptide binding]; other site
863767005897	active site
863767005898	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
863767005899	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
863767005900	NAD binding site [chemical binding]; other site
863767005901	ATP-grasp domain; Region: ATP-grasp; pfam02222
863767005902	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
863767005903	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
863767005904	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
863767005905	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
863767005906	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
863767005907	Zn2+ binding site [ion binding]; other site
863767005908	Mg2+ binding site [ion binding]; other site
863767005909	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
863767005910	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
863767005911	Walker A/P-loop; other site
863767005912	ATP binding site [chemical binding]; other site
863767005913	Q-loop/lid; other site
863767005914	ABC transporter signature motif; other site
863767005915	Walker B; other site
863767005916	D-loop; other site
863767005917	H-loop/switch region; other site
863767005918	peptidase T; Region: peptidase-T; TIGR01882
863767005919	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
863767005920	metal binding site [ion binding]; metal-binding site
863767005921	dimer interface [polypeptide binding]; other site
863767005922	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
863767005923	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
863767005924	active site
863767005925	putative catalytic site [active]
863767005926	DNA binding site [nucleotide binding]
863767005927	putative phosphate binding site [ion binding]; other site
863767005928	metal binding site A [ion binding]; metal-binding site
863767005929	AP binding site [nucleotide binding]; other site
863767005930	metal binding site B [ion binding]; metal-binding site
863767005931	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
863767005932	23S rRNA binding site [nucleotide binding]; other site
863767005933	L21 binding site [polypeptide binding]; other site
863767005934	L13 binding site [polypeptide binding]; other site
863767005935	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
863767005936	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
863767005937	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
863767005938	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
863767005939	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
863767005940	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767005941	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
863767005942	Substrate binding site [chemical binding]; other site
863767005943	Leucine rich repeat; Region: LRR_8; pfam13855
863767005944	LRR adjacent; Region: LRR_adjacent; pfam08191
863767005945	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
863767005946	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
863767005947	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
863767005948	DNA binding residues [nucleotide binding]
863767005949	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
863767005950	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
863767005951	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
863767005952	Putative heavy-metal-binding; Region: YbjQ_1; pfam01906
863767005953	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
863767005954	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
863767005955	RimM N-terminal domain; Region: RimM; pfam01782
863767005956	PRC-barrel domain; Region: PRC; pfam05239
863767005957	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
863767005958	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
863767005959	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
863767005960	catalytic triad [active]
863767005961	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
863767005962	KH domain; Region: KH_4; pfam13083
863767005963	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
863767005964	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
863767005965	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
863767005966	signal recognition particle protein; Provisional; Region: PRK10867
863767005967	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
863767005968	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
863767005969	P loop; other site
863767005970	GTP binding site [chemical binding]; other site
863767005971	Signal peptide binding domain; Region: SRP_SPB; pfam02978
863767005972	putative DNA-binding protein; Validated; Region: PRK00118
863767005973	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
863767005974	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
863767005975	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
863767005976	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
863767005977	P loop; other site
863767005978	GTP binding site [chemical binding]; other site
863767005979	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
863767005980	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
863767005981	Walker A/P-loop; other site
863767005982	ATP binding site [chemical binding]; other site
863767005983	Q-loop/lid; other site
863767005984	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
863767005985	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
863767005986	linker region; other site
863767005987	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
863767005988	ABC transporter signature motif; other site
863767005989	Walker B; other site
863767005990	D-loop; other site
863767005991	H-loop/switch region; other site
863767005992	ribonuclease III; Reviewed; Region: rnc; PRK00102
863767005993	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
863767005994	dimerization interface [polypeptide binding]; other site
863767005995	active site
863767005996	metal binding site [ion binding]; metal-binding site
863767005997	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
863767005998	dsRNA binding site [nucleotide binding]; other site
863767005999	acyl carrier protein; Provisional; Region: acpP; PRK00982
863767006000	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
863767006001	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
863767006002	NAD(P) binding site [chemical binding]; other site
863767006003	homotetramer interface [polypeptide binding]; other site
863767006004	homodimer interface [polypeptide binding]; other site
863767006005	active site
863767006006	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
863767006007	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
863767006008	putative phosphate acyltransferase; Provisional; Region: PRK05331
863767006009	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
863767006010	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
863767006011	active site 2 [active]
863767006012	active site 1 [active]
863767006013	Y-family of DNA polymerases; Region: PolY; cl12025
863767006014	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
863767006015	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
863767006016	generic binding surface II; other site
863767006017	ssDNA binding site; other site
863767006018	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
863767006019	ATP binding site [chemical binding]; other site
863767006020	putative Mg++ binding site [ion binding]; other site
863767006021	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
863767006022	nucleotide binding region [chemical binding]; other site
863767006023	ATP-binding site [chemical binding]; other site
863767006024	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
863767006025	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
863767006026	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
863767006027	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
863767006028	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
863767006029	putative L-serine binding site [chemical binding]; other site
863767006030	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
863767006031	DAK2 domain; Region: Dak2; pfam02734
863767006032	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
863767006033	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
863767006034	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
863767006035	Thiamine pyrophosphokinase; Region: TPK; cd07995
863767006036	active site
863767006037	dimerization interface [polypeptide binding]; other site
863767006038	thiamine binding site [chemical binding]; other site
863767006039	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
863767006040	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
863767006041	substrate binding site [chemical binding]; other site
863767006042	hexamer interface [polypeptide binding]; other site
863767006043	metal binding site [ion binding]; metal-binding site
863767006044	GTPase RsgA; Reviewed; Region: PRK00098
863767006045	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
863767006046	RNA binding site [nucleotide binding]; other site
863767006047	homodimer interface [polypeptide binding]; other site
863767006048	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
863767006049	GTPase/Zn-binding domain interface [polypeptide binding]; other site
863767006050	GTP/Mg2+ binding site [chemical binding]; other site
863767006051	G4 box; other site
863767006052	G1 box; other site
863767006053	Switch I region; other site
863767006054	G2 box; other site
863767006055	G3 box; other site
863767006056	Switch II region; other site
863767006057	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
863767006058	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
863767006059	active site
863767006060	ATP binding site [chemical binding]; other site
863767006061	substrate binding site [chemical binding]; other site
863767006062	activation loop (A-loop); other site
863767006063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
863767006064	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
863767006065	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
863767006066	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
863767006067	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
863767006068	Protein phosphatase 2C; Region: PP2C; pfam00481
863767006069	active site
863767006070	16S rRNA methyltransferase B; Provisional; Region: PRK14902
863767006071	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
863767006072	putative RNA binding site [nucleotide binding]; other site
863767006073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767006074	S-adenosylmethionine binding site [chemical binding]; other site
863767006075	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
863767006076	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
863767006077	putative active site [active]
863767006078	substrate binding site [chemical binding]; other site
863767006079	putative cosubstrate binding site; other site
863767006080	catalytic site [active]
863767006081	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
863767006082	substrate binding site [chemical binding]; other site
863767006083	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
863767006084	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
863767006085	ATP binding site [chemical binding]; other site
863767006086	putative Mg++ binding site [ion binding]; other site
863767006087	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
863767006088	ATP-binding site [chemical binding]; other site
863767006089	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
863767006090	Flavoprotein; Region: Flavoprotein; pfam02441
863767006091	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
863767006092	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
863767006093	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
863767006094	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
863767006095	catalytic site [active]
863767006096	G-X2-G-X-G-K; other site
863767006097	Uncharacterized stress-induced protein [Function unknown]; Region: COG1561
863767006098	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
863767006099	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
863767006100	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
863767006101	Domain of unknown function (DUF814); Region: DUF814; pfam05670
863767006102	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
863767006103	putative NAD(P) binding site [chemical binding]; other site
863767006104	homodimer interface [polypeptide binding]; other site
863767006105	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
863767006106	active site
863767006107	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
863767006108	active site
863767006109	dimer interface [polypeptide binding]; other site
863767006110	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
863767006111	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
863767006112	heterodimer interface [polypeptide binding]; other site
863767006113	active site
863767006114	FMN binding site [chemical binding]; other site
863767006115	homodimer interface [polypeptide binding]; other site
863767006116	substrate binding site [chemical binding]; other site
863767006117	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
863767006118	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
863767006119	FAD binding pocket [chemical binding]; other site
863767006120	FAD binding motif [chemical binding]; other site
863767006121	phosphate binding motif [ion binding]; other site
863767006122	beta-alpha-beta structure motif; other site
863767006123	NAD binding pocket [chemical binding]; other site
863767006124	Iron coordination center [ion binding]; other site
863767006125	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
863767006126	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
863767006127	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
863767006128	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
863767006129	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
863767006130	ATP-grasp domain; Region: ATP-grasp_4; cl17255
863767006131	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
863767006132	IMP binding site; other site
863767006133	dimer interface [polypeptide binding]; other site
863767006134	interdomain contacts; other site
863767006135	partial ornithine binding site; other site
863767006136	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
863767006137	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
863767006138	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
863767006139	catalytic site [active]
863767006140	subunit interface [polypeptide binding]; other site
863767006141	dihydroorotase; Validated; Region: pyrC; PRK09357
863767006142	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
863767006143	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
863767006144	active site
863767006145	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
863767006146	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
863767006147	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
863767006148	uracil transporter; Provisional; Region: PRK10720
863767006149	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
863767006150	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
863767006151	active site
863767006152	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
863767006153	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
863767006154	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
863767006155	RNA binding surface [nucleotide binding]; other site
863767006156	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
863767006157	active site
863767006158	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
863767006159	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
863767006160	Sulfate transporter family; Region: Sulfate_transp; pfam00916
863767006161	multidrug efflux protein; Reviewed; Region: PRK01766
863767006162	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
863767006163	cation binding site [ion binding]; other site
863767006164	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
863767006165	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
863767006166	metal binding site [ion binding]; metal-binding site
863767006167	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
863767006168	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
863767006169	ABC-ATPase subunit  interface; other site
863767006170	dimer interface [polypeptide binding]; other site
863767006171	putative PBP binding regions; other site
863767006172	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
863767006173	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
863767006174	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
863767006175	MarR family; Region: MarR; pfam01047
863767006176	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
863767006177	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
863767006178	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
863767006179	protein binding site [polypeptide binding]; other site
863767006180	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
863767006181	Catalytic dyad [active]
863767006182	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
863767006183	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
863767006184	metal-binding site [ion binding]
863767006185	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
863767006186	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
863767006187	metal-binding site [ion binding]
863767006188	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
863767006189	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767006190	motif II; other site
863767006191	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
863767006192	putative homodimer interface [polypeptide binding]; other site
863767006193	putative homotetramer interface [polypeptide binding]; other site
863767006194	putative allosteric switch controlling residues; other site
863767006195	putative metal binding site [ion binding]; other site
863767006196	putative homodimer-homodimer interface [polypeptide binding]; other site
863767006197	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
863767006198	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
863767006199	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
863767006200	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
863767006201	hypothetical protein; Provisional; Region: PRK13672
863767006202	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
863767006203	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
863767006204	methionine sulfoxide reductase B; Provisional; Region: PRK00222
863767006205	SelR domain; Region: SelR; pfam01641
863767006206	methionine sulfoxide reductase A; Provisional; Region: PRK14054
863767006207	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698
863767006208	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
863767006209	active site
863767006210	catalytic triad [active]
863767006211	oxyanion hole [active]
863767006212	EDD domain protein, DegV family; Region: DegV; TIGR00762
863767006213	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
863767006214	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
863767006215	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
863767006216	HTH domain; Region: HTH_11; pfam08279
863767006217	FOG: CBS domain [General function prediction only]; Region: COG0517
863767006218	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
863767006219	PEP synthetase regulatory protein; Provisional; Region: PRK05339
863767006220	pyruvate phosphate dikinase; Provisional; Region: PRK09279
863767006221	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
863767006222	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
863767006223	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
863767006224	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
863767006225	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
863767006226	Predicted membrane protein [Function unknown]; Region: COG4129
863767006227	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
863767006228	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
863767006229	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
863767006230	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
863767006231	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
863767006232	active site
863767006233	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
863767006234	substrate binding site [chemical binding]; other site
863767006235	metal binding site [ion binding]; metal-binding site
863767006236	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
863767006237	Methyltransferase domain; Region: Methyltransf_18; pfam12847
863767006238	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
863767006239	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
863767006240	folate binding site [chemical binding]; other site
863767006241	NADP+ binding site [chemical binding]; other site
863767006242	thymidylate synthase; Region: thym_sym; TIGR03284
863767006243	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
863767006244	dimerization interface [polypeptide binding]; other site
863767006245	active site
863767006246	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
863767006247	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
863767006248	Walker A/P-loop; other site
863767006249	ATP binding site [chemical binding]; other site
863767006250	Q-loop/lid; other site
863767006251	ABC transporter signature motif; other site
863767006252	Walker B; other site
863767006253	D-loop; other site
863767006254	H-loop/switch region; other site
863767006255	ABC transporter; Region: ABC_tran_2; pfam12848
863767006256	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
863767006257	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
863767006258	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
863767006259	Potassium binding sites [ion binding]; other site
863767006260	Cesium cation binding sites [ion binding]; other site
863767006261	manganese transport transcriptional regulator; Provisional; Region: PRK03902
863767006262	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
863767006263	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
863767006264	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
863767006265	DNA-binding site [nucleotide binding]; DNA binding site
863767006266	RNA-binding motif; other site
863767006267	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
863767006268	RNA/DNA hybrid binding site [nucleotide binding]; other site
863767006269	active site
863767006270	5'-3' exonuclease; Region: 53EXOc; smart00475
863767006271	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
863767006272	active site
863767006273	metal binding site 1 [ion binding]; metal-binding site
863767006274	putative 5' ssDNA interaction site; other site
863767006275	metal binding site 3; metal-binding site
863767006276	metal binding site 2 [ion binding]; metal-binding site
863767006277	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
863767006278	putative DNA binding site [nucleotide binding]; other site
863767006279	putative metal binding site [ion binding]; other site
863767006280	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
863767006281	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
863767006282	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
863767006283	putative active site [active]
863767006284	xanthine permease; Region: pbuX; TIGR03173
863767006285	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
863767006286	active site
863767006287	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
863767006288	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
863767006289	active site
863767006290	Zn binding site [ion binding]; other site
863767006291	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
863767006292	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
863767006293	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
863767006294	cell division protein GpsB; Provisional; Region: PRK14127
863767006295	DivIVA domain; Region: DivI1A_domain; TIGR03544
863767006296	Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884
863767006297	hypothetical protein; Provisional; Region: PRK13660
863767006298	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
863767006299	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
863767006300	Transglycosylase; Region: Transgly; pfam00912
863767006301	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
863767006302	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
863767006303	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
863767006304	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
863767006305	minor groove reading motif; other site
863767006306	helix-hairpin-helix signature motif; other site
863767006307	substrate binding pocket [chemical binding]; other site
863767006308	active site
863767006309	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
863767006310	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
863767006311	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
863767006312	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
863767006313	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
863767006314	putative dimer interface [polypeptide binding]; other site
863767006315	putative anticodon binding site; other site
863767006316	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
863767006317	homodimer interface [polypeptide binding]; other site
863767006318	motif 1; other site
863767006319	motif 2; other site
863767006320	active site
863767006321	motif 3; other site
863767006322	aspartate aminotransferase; Provisional; Region: PRK05764
863767006323	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
863767006324	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767006325	homodimer interface [polypeptide binding]; other site
863767006326	catalytic residue [active]
863767006327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
863767006328	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
863767006329	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
863767006330	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
863767006331	active site
863767006332	catalytic site [active]
863767006333	substrate binding site [chemical binding]; other site
863767006334	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
863767006335	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
863767006336	putative Mg++ binding site [ion binding]; other site
863767006337	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
863767006338	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
863767006339	tetramerization interface [polypeptide binding]; other site
863767006340	active site
863767006341	pantoate--beta-alanine ligase; Region: panC; TIGR00018
863767006342	Pantoate-beta-alanine ligase; Region: PanC; cd00560
863767006343	active site
863767006344	ATP-binding site [chemical binding]; other site
863767006345	pantoate-binding site; other site
863767006346	HXXH motif; other site
863767006347	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
863767006348	active site
863767006349	oligomerization interface [polypeptide binding]; other site
863767006350	metal binding site [ion binding]; metal-binding site
863767006351	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
863767006352	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
863767006353	catalytic residues [active]
863767006354	Biotin operon repressor [Transcription]; Region: BirA; COG1654
863767006355	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
863767006356	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
863767006357	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
863767006358	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
863767006359	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
863767006360	active site
863767006361	NTP binding site [chemical binding]; other site
863767006362	metal binding triad [ion binding]; metal-binding site
863767006363	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
863767006364	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
863767006365	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
863767006366	active site
863767006367	dimer interfaces [polypeptide binding]; other site
863767006368	catalytic residues [active]
863767006369	dihydrodipicolinate reductase; Provisional; Region: PRK00048
863767006370	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
863767006371	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
863767006372	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
863767006373	homodimer interface [polypeptide binding]; other site
863767006374	metal binding site [ion binding]; metal-binding site
863767006375	Uncharacterized conserved protein [Function unknown]; Region: COG1284
863767006376	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
863767006377	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
863767006378	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
863767006379	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
863767006380	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
863767006381	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
863767006382	metal binding site [ion binding]; metal-binding site
863767006383	active site
863767006384	I-site; other site
863767006385	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
863767006386	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
863767006387	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
863767006388	metal binding site [ion binding]; metal-binding site
863767006389	active site
863767006390	I-site; other site
863767006391	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
863767006392	malate dehydrogenase; Provisional; Region: PRK13529
863767006393	Malic enzyme, N-terminal domain; Region: malic; pfam00390
863767006394	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
863767006395	NAD(P) binding pocket [chemical binding]; other site
863767006396	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
863767006397	Beta-lactamase; Region: Beta-lactamase; pfam00144
863767006398	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
863767006399	Pyruvate formate lyase 1; Region: PFL1; cd01678
863767006400	coenzyme A binding site [chemical binding]; other site
863767006401	active site
863767006402	catalytic residues [active]
863767006403	HI0933-like protein; Region: HI0933_like; pfam03486
863767006404	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
863767006405	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
863767006406	Predicted membrane protein [Function unknown]; Region: COG4347
863767006407	hypothetical protein; Provisional; Region: PRK03636
863767006408	UPF0302 domain; Region: UPF0302; pfam08864
863767006409	IDEAL domain; Region: IDEAL; pfam08858
863767006410	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
863767006411	binding surface
863767006412	TPR motif; other site
863767006413	TPR repeat; Region: TPR_11; pfam13414
863767006414	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
863767006415	binding surface
863767006416	TPR motif; other site
863767006417	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
863767006418	binding surface
863767006419	TPR motif; other site
863767006420	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
863767006421	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
863767006422	hinge; other site
863767006423	active site
863767006424	prephenate dehydrogenase; Validated; Region: PRK06545
863767006425	prephenate dehydrogenase; Validated; Region: PRK08507
863767006426	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
863767006427	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
863767006428	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
863767006429	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767006430	homodimer interface [polypeptide binding]; other site
863767006431	catalytic residue [active]
863767006432	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
863767006433	homotrimer interaction site [polypeptide binding]; other site
863767006434	active site
863767006435	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
863767006436	active site
863767006437	dimer interface [polypeptide binding]; other site
863767006438	metal binding site [ion binding]; metal-binding site
863767006439	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
863767006440	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
863767006441	Tetramer interface [polypeptide binding]; other site
863767006442	active site
863767006443	FMN-binding site [chemical binding]; other site
863767006444	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
863767006445	active site
863767006446	multimer interface [polypeptide binding]; other site
863767006447	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
863767006448	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
863767006449	substrate binding pocket [chemical binding]; other site
863767006450	chain length determination region; other site
863767006451	substrate-Mg2+ binding site; other site
863767006452	catalytic residues [active]
863767006453	aspartate-rich region 1; other site
863767006454	active site lid residues [active]
863767006455	aspartate-rich region 2; other site
863767006456	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
863767006457	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767006458	S-adenosylmethionine binding site [chemical binding]; other site
863767006459	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
863767006460	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
863767006461	homodecamer interface [polypeptide binding]; other site
863767006462	GTP cyclohydrolase I; Provisional; Region: PLN03044
863767006463	active site
863767006464	putative catalytic site residues [active]
863767006465	zinc binding site [ion binding]; other site
863767006466	GTP-CH-I/GFRP interaction surface; other site
863767006467	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
863767006468	IHF dimer interface [polypeptide binding]; other site
863767006469	IHF - DNA interface [nucleotide binding]; other site
863767006470	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
863767006471	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
863767006472	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
863767006473	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
863767006474	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
863767006475	GTP-binding protein Der; Reviewed; Region: PRK00093
863767006476	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
863767006477	G1 box; other site
863767006478	GTP/Mg2+ binding site [chemical binding]; other site
863767006479	Switch I region; other site
863767006480	G2 box; other site
863767006481	Switch II region; other site
863767006482	G3 box; other site
863767006483	G4 box; other site
863767006484	G5 box; other site
863767006485	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
863767006486	G1 box; other site
863767006487	GTP/Mg2+ binding site [chemical binding]; other site
863767006488	Switch I region; other site
863767006489	G2 box; other site
863767006490	G3 box; other site
863767006491	Switch II region; other site
863767006492	G4 box; other site
863767006493	G5 box; other site
863767006494	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
863767006495	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
863767006496	RNA binding site [nucleotide binding]; other site
863767006497	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
863767006498	RNA binding site [nucleotide binding]; other site
863767006499	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
863767006500	RNA binding site [nucleotide binding]; other site
863767006501	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
863767006502	RNA binding site [nucleotide binding]; other site
863767006503	cytidylate kinase; Provisional; Region: cmk; PRK00023
863767006504	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
863767006505	CMP-binding site; other site
863767006506	The sites determining sugar specificity; other site
863767006507	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
863767006508	active site
863767006509	homotetramer interface [polypeptide binding]; other site
863767006510	homodimer interface [polypeptide binding]; other site
863767006511	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
863767006512	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
863767006513	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
863767006514	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
863767006515	ATP binding site [chemical binding]; other site
863767006516	putative Mg++ binding site [ion binding]; other site
863767006517	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
863767006518	nucleotide binding region [chemical binding]; other site
863767006519	ATP-binding site [chemical binding]; other site
863767006520	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
863767006521	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
863767006522	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
863767006523	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767006524	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767006525	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767006526	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767006527	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767006528	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767006529	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767006530	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767006531	Predicted membrane protein [Function unknown]; Region: COG3601
863767006532	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
863767006533	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
863767006534	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
863767006535	dimerization interface [polypeptide binding]; other site
863767006536	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
863767006537	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
863767006538	dimer interface [polypeptide binding]; other site
863767006539	phosphorylation site [posttranslational modification]
863767006540	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767006541	ATP binding site [chemical binding]; other site
863767006542	Mg2+ binding site [ion binding]; other site
863767006543	G-X-G motif; other site
863767006544	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
863767006545	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767006546	active site
863767006547	phosphorylation site [posttranslational modification]
863767006548	intermolecular recognition site; other site
863767006549	dimerization interface [polypeptide binding]; other site
863767006550	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
863767006551	DNA binding site [nucleotide binding]
863767006552	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
863767006553	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
863767006554	RNA binding surface [nucleotide binding]; other site
863767006555	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
863767006556	active site
863767006557	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
863767006558	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
863767006559	diaminopimelate decarboxylase; Region: lysA; TIGR01048
863767006560	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
863767006561	active site
863767006562	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
863767006563	substrate binding site [chemical binding]; other site
863767006564	catalytic residues [active]
863767006565	dimer interface [polypeptide binding]; other site
863767006566	purine nucleoside phosphorylase; Provisional; Region: PRK08202
863767006567	phosphopentomutase; Provisional; Region: PRK05362
863767006568	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
863767006569	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
863767006570	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
863767006571	active site
863767006572	Int/Topo IB signature motif; other site
863767006573	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
863767006574	metal binding site 2 [ion binding]; metal-binding site
863767006575	putative DNA binding helix; other site
863767006576	metal binding site 1 [ion binding]; metal-binding site
863767006577	dimer interface [polypeptide binding]; other site
863767006578	structural Zn2+ binding site [ion binding]; other site
863767006579	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
863767006580	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
863767006581	ABC-ATPase subunit  interface; other site
863767006582	dimer interface [polypeptide binding]; other site
863767006583	putative PBP binding regions; other site
863767006584	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
863767006585	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
863767006586	ABC-ATPase subunit  interface; other site
863767006587	dimer interface [polypeptide binding]; other site
863767006588	putative PBP binding regions; other site
863767006589	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
863767006590	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
863767006591	putative ligand binding residues [chemical binding]; other site
863767006592	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
863767006593	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
863767006594	Walker A/P-loop; other site
863767006595	ATP binding site [chemical binding]; other site
863767006596	Q-loop/lid; other site
863767006597	ABC transporter signature motif; other site
863767006598	Walker B; other site
863767006599	D-loop; other site
863767006600	H-loop/switch region; other site
863767006601	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
863767006602	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
863767006603	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
863767006604	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
863767006605	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
863767006606	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
863767006607	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
863767006608	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
863767006609	Walker A/P-loop; other site
863767006610	ATP binding site [chemical binding]; other site
863767006611	Q-loop/lid; other site
863767006612	ABC transporter signature motif; other site
863767006613	Walker B; other site
863767006614	D-loop; other site
863767006615	H-loop/switch region; other site
863767006616	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
863767006617	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
863767006618	dimer interface [polypeptide binding]; other site
863767006619	ADP-ribose binding site [chemical binding]; other site
863767006620	active site
863767006621	nudix motif; other site
863767006622	metal binding site [ion binding]; metal-binding site
863767006623	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
863767006624	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
863767006625	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
863767006626	active site
863767006627	DNA polymerase IV; Validated; Region: PRK02406
863767006628	DNA binding site [nucleotide binding]
863767006629	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
863767006630	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
863767006631	NAD(P) binding site [chemical binding]; other site
863767006632	active site
863767006633	ribonuclease Z; Region: RNase_Z; TIGR02651
863767006634	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
863767006635	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
863767006636	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
863767006637	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
863767006638	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
863767006639	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767006640	Coenzyme A binding pocket [chemical binding]; other site
863767006641	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
863767006642	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
863767006643	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
863767006644	PYR/PP interface [polypeptide binding]; other site
863767006645	dimer interface [polypeptide binding]; other site
863767006646	TPP binding site [chemical binding]; other site
863767006647	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
863767006648	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
863767006649	TPP-binding site [chemical binding]; other site
863767006650	dimer interface [polypeptide binding]; other site
863767006651	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
863767006652	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
863767006653	putative valine binding site [chemical binding]; other site
863767006654	dimer interface [polypeptide binding]; other site
863767006655	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
863767006656	ketol-acid reductoisomerase; Provisional; Region: PRK05479
863767006657	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
863767006658	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
863767006659	2-isopropylmalate synthase; Validated; Region: PRK00915
863767006660	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
863767006661	active site
863767006662	catalytic residues [active]
863767006663	metal binding site [ion binding]; metal-binding site
863767006664	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
863767006665	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
863767006666	tartrate dehydrogenase; Region: TTC; TIGR02089
863767006667	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
863767006668	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
863767006669	substrate binding site [chemical binding]; other site
863767006670	ligand binding site [chemical binding]; other site
863767006671	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
863767006672	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
863767006673	substrate binding site [chemical binding]; other site
863767006674	threonine dehydratase; Validated; Region: PRK08639
863767006675	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
863767006676	tetramer interface [polypeptide binding]; other site
863767006677	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767006678	catalytic residue [active]
863767006679	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
863767006680	alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252
863767006681	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
863767006682	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
863767006683	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
863767006684	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
863767006685	Transcriptional regulators [Transcription]; Region: PurR; COG1609
863767006686	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
863767006687	DNA binding site [nucleotide binding]
863767006688	domain linker motif; other site
863767006689	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
863767006690	dimerization interface [polypeptide binding]; other site
863767006691	ligand binding site [chemical binding]; other site
863767006692	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
863767006693	intersubunit interface [polypeptide binding]; other site
863767006694	active site
863767006695	catalytic residue [active]
863767006696	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
863767006697	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
863767006698	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
863767006699	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
863767006700	active pocket/dimerization site; other site
863767006701	active site
863767006702	phosphorylation site [posttranslational modification]
863767006703	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
863767006704	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
863767006705	putative active site [active]
863767006706	SIS domain; Region: SIS; pfam01380
863767006707	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
863767006708	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
863767006709	dimer interface [polypeptide binding]; other site
863767006710	active site
863767006711	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
863767006712	dimer interface [polypeptide binding]; other site
863767006713	active site
863767006714	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
863767006715	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
863767006716	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
863767006717	active site
863767006718	phosphorylation site [posttranslational modification]
863767006719	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
863767006720	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767006721	DNA-binding site [nucleotide binding]; DNA binding site
863767006722	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
863767006723	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
863767006724	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767006725	DNA-binding site [nucleotide binding]; DNA binding site
863767006726	UTRA domain; Region: UTRA; pfam07702
863767006727	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
863767006728	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
863767006729	active site
863767006730	catalytic tetrad [active]
863767006731	acetolactate synthase; Reviewed; Region: PRK08617
863767006732	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
863767006733	PYR/PP interface [polypeptide binding]; other site
863767006734	dimer interface [polypeptide binding]; other site
863767006735	TPP binding site [chemical binding]; other site
863767006736	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
863767006737	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
863767006738	TPP-binding site [chemical binding]; other site
863767006739	dimer interface [polypeptide binding]; other site
863767006740	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
863767006741	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
863767006742	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
863767006743	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
863767006744	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767006745	dimer interface [polypeptide binding]; other site
863767006746	conserved gate region; other site
863767006747	ABC-ATPase subunit interface; other site
863767006748	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
863767006749	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767006750	dimer interface [polypeptide binding]; other site
863767006751	conserved gate region; other site
863767006752	ABC-ATPase subunit interface; other site
863767006753	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
863767006754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767006755	active site
863767006756	phosphorylation site [posttranslational modification]
863767006757	intermolecular recognition site; other site
863767006758	dimerization interface [polypeptide binding]; other site
863767006759	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
863767006760	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
863767006761	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
863767006762	dimerization interface [polypeptide binding]; other site
863767006763	Histidine kinase; Region: His_kinase; pfam06580
863767006764	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767006765	ATP binding site [chemical binding]; other site
863767006766	Mg2+ binding site [ion binding]; other site
863767006767	G-X-G motif; other site
863767006768	Predicted integral membrane protein [Function unknown]; Region: COG5578
863767006769	Uncharacterized conserved protein [Function unknown]; Region: COG3538
863767006770	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
863767006771	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
863767006772	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
863767006773	active site
863767006774	metal binding site [ion binding]; metal-binding site
863767006775	homodimer interface [polypeptide binding]; other site
863767006776	catalytic site [active]
863767006777	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
863767006778	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
863767006779	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
863767006780	active site
863767006781	catalytic site [active]
863767006782	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
863767006783	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
863767006784	DNA-binding site [nucleotide binding]; DNA binding site
863767006785	RNA-binding motif; other site
863767006786	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
863767006787	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
863767006788	active site
863767006789	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
863767006790	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
863767006791	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
863767006792	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
863767006793	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
863767006794	active site
863767006795	HIGH motif; other site
863767006796	nucleotide binding site [chemical binding]; other site
863767006797	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
863767006798	active site
863767006799	KMSKS motif; other site
863767006800	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
863767006801	tRNA binding surface [nucleotide binding]; other site
863767006802	anticodon binding site; other site
863767006803	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
863767006804	DivIVA protein; Region: DivIVA; pfam05103
863767006805	DivIVA domain; Region: DivI1A_domain; TIGR03544
863767006806	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
863767006807	HTH domain; Region: HTH_11; pfam08279
863767006808	3H domain; Region: 3H; pfam02829
863767006809	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
863767006810	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
863767006811	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
863767006812	catalytic residue [active]
863767006813	L-aspartate oxidase; Provisional; Region: PRK08071
863767006814	L-aspartate oxidase; Provisional; Region: PRK06175
863767006815	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
863767006816	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
863767006817	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
863767006818	dimerization interface [polypeptide binding]; other site
863767006819	active site
863767006820	quinolinate synthetase; Provisional; Region: PRK09375
863767006821	Mga helix-turn-helix domain; Region: Mga; pfam05043
863767006822	Methyltransferase domain; Region: Methyltransf_31; pfam13847
863767006823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767006824	S-adenosylmethionine binding site [chemical binding]; other site
863767006825	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
863767006826	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
863767006827	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
863767006828	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
863767006829	RNA binding surface [nucleotide binding]; other site
863767006830	YGGT family; Region: YGGT; pfam02325
863767006831	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
863767006832	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
863767006833	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
863767006834	catalytic residue [active]
863767006835	cell division protein FtsZ; Validated; Region: PRK09330
863767006836	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
863767006837	nucleotide binding site [chemical binding]; other site
863767006838	SulA interaction site; other site
863767006839	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
863767006840	Cell division protein FtsA; Region: FtsA; smart00842
863767006841	Cell division protein FtsA; Region: FtsA; pfam14450
863767006842	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
863767006843	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
863767006844	Cell division protein FtsQ; Region: FtsQ; pfam03799
863767006845	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
863767006846	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
863767006847	active site
863767006848	homodimer interface [polypeptide binding]; other site
863767006849	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
863767006850	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
863767006851	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
863767006852	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
863767006853	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
863767006854	Mg++ binding site [ion binding]; other site
863767006855	putative catalytic motif [active]
863767006856	putative substrate binding site [chemical binding]; other site
863767006857	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
863767006858	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
863767006859	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
863767006860	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
863767006861	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
863767006862	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
863767006863	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
863767006864	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
863767006865	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
863767006866	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
863767006867	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
863767006868	MraW methylase family; Region: Methyltransf_5; pfam01795
863767006869	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
863767006870	MraZ protein; Region: MraZ; pfam02381
863767006871	MraZ protein; Region: MraZ; pfam02381
863767006872	Major Facilitator Superfamily; Region: MFS_1; pfam07690
863767006873	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767006874	putative substrate translocation pore; other site
863767006875	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
863767006876	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
863767006877	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
863767006878	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
863767006879	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
863767006880	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
863767006881	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
863767006882	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
863767006883	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
863767006884	hypothetical protein; Provisional; Region: PRK13670
863767006885	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
863767006886	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
863767006887	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
863767006888	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767006889	Walker A/P-loop; other site
863767006890	ATP binding site [chemical binding]; other site
863767006891	Q-loop/lid; other site
863767006892	ABC transporter signature motif; other site
863767006893	Walker B; other site
863767006894	D-loop; other site
863767006895	H-loop/switch region; other site
863767006896	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
863767006897	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
863767006898	protein binding site [polypeptide binding]; other site
863767006899	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
863767006900	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
863767006901	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
863767006902	active site
863767006903	(T/H)XGH motif; other site
863767006904	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
863767006905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767006906	S-adenosylmethionine binding site [chemical binding]; other site
863767006907	hypothetical protein; Provisional; Region: PRK02886
863767006908	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
863767006909	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
863767006910	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
863767006911	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
863767006912	UbiA prenyltransferase family; Region: UbiA; pfam01040
863767006913	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
863767006914	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
863767006915	Ion transport protein; Region: Ion_trans; pfam00520
863767006916	Ion channel; Region: Ion_trans_2; pfam07885
863767006917	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
863767006918	MOSC domain; Region: MOSC; pfam03473
863767006919	3-alpha domain; Region: 3-alpha; pfam03475
863767006920	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
863767006921	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
863767006922	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
863767006923	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953
863767006924	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
863767006925	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
863767006926	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
863767006927	active site
863767006928	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
863767006929	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
863767006930	ring oligomerisation interface [polypeptide binding]; other site
863767006931	ATP/Mg binding site [chemical binding]; other site
863767006932	stacking interactions; other site
863767006933	hinge regions; other site
863767006934	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
863767006935	oligomerisation interface [polypeptide binding]; other site
863767006936	mobile loop; other site
863767006937	roof hairpin; other site
863767006938	CAAX protease self-immunity; Region: Abi; pfam02517
863767006939	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
863767006940	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
863767006941	CoA binding domain; Region: CoA_binding; pfam02629
863767006942	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
863767006943	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
863767006944	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
863767006945	ABC transporter; Region: ABC_tran_2; pfam12848
863767006946	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
863767006947	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
863767006948	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
863767006949	UGMP family protein; Validated; Region: PRK09604
863767006950	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
863767006951	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
863767006952	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767006953	Coenzyme A binding pocket [chemical binding]; other site
863767006954	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
863767006955	Glycoprotease family; Region: Peptidase_M22; pfam00814
863767006956	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
863767006957	camphor resistance protein CrcB; Provisional; Region: PRK14214
863767006958	camphor resistance protein CrcB; Provisional; Region: PRK14231
863767006959	Uncharacterized conserved protein [Function unknown]; Region: COG4832
863767006960	Phosphotransferase enzyme family; Region: APH; pfam01636
863767006961	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
863767006962	active site
863767006963	substrate binding site [chemical binding]; other site
863767006964	ATP binding site [chemical binding]; other site
863767006965	Cna protein B-type domain; Region: Cna_B; pfam05738
863767006966	Cna protein B-type domain; Region: Cna_B; pfam05738
863767006967	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767006968	Cna protein B-type domain; Region: Cna_B; pfam05738
863767006969	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767006970	non-specific DNA binding site [nucleotide binding]; other site
863767006971	salt bridge; other site
863767006972	sequence-specific DNA binding site [nucleotide binding]; other site
863767006973	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
863767006974	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
863767006975	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
863767006976	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
863767006977	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
863767006978	argininosuccinate synthase; Provisional; Region: PRK13820
863767006979	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
863767006980	ANP binding site [chemical binding]; other site
863767006981	Substrate Binding Site II [chemical binding]; other site
863767006982	Substrate Binding Site I [chemical binding]; other site
863767006983	argininosuccinate lyase; Provisional; Region: PRK00855
863767006984	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
863767006985	active sites [active]
863767006986	tetramer interface [polypeptide binding]; other site
863767006987	BCCT family transporter; Region: BCCT; pfam02028
863767006988	hypothetical protein; Provisional; Region: PRK06357
863767006989	active site
863767006990	intersubunit interface [polypeptide binding]; other site
863767006991	Zn2+ binding site [ion binding]; other site
863767006992	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
863767006993	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
863767006994	putative substrate binding site [chemical binding]; other site
863767006995	putative ATP binding site [chemical binding]; other site
863767006996	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
863767006997	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
863767006998	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
863767006999	active site
863767007000	P-loop; other site
863767007001	phosphorylation site [posttranslational modification]
863767007002	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767007003	active site
863767007004	phosphorylation site [posttranslational modification]
863767007005	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
863767007006	PRD domain; Region: PRD; pfam00874
863767007007	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
863767007008	active site
863767007009	P-loop; other site
863767007010	phosphorylation site [posttranslational modification]
863767007011	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762
863767007012	active site
863767007013	phosphorylation site [posttranslational modification]
863767007014	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
863767007015	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767007016	DNA-binding site [nucleotide binding]; DNA binding site
863767007017	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
863767007018	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767007019	homodimer interface [polypeptide binding]; other site
863767007020	catalytic residue [active]
863767007021	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
863767007022	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
863767007023	active site
863767007024	multimer interface [polypeptide binding]; other site
863767007025	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
863767007026	predicted active site [active]
863767007027	catalytic triad [active]
863767007028	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
863767007029	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
863767007030	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
863767007031	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
863767007032	G1 box; other site
863767007033	GTP/Mg2+ binding site [chemical binding]; other site
863767007034	Switch I region; other site
863767007035	G2 box; other site
863767007036	G3 box; other site
863767007037	Switch II region; other site
863767007038	G4 box; other site
863767007039	G5 box; other site
863767007040	Nucleoside recognition; Region: Gate; pfam07670
863767007041	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
863767007042	Nucleoside recognition; Region: Gate; pfam07670
863767007043	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
863767007044	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
863767007045	putative active site [active]
863767007046	putative metal binding site [ion binding]; other site
863767007047	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
863767007048	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
863767007049	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
863767007050	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
863767007051	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
863767007052	active site
863767007053	dimer interface [polypeptide binding]; other site
863767007054	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
863767007055	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
863767007056	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
863767007057	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
863767007058	dimer interface [polypeptide binding]; other site
863767007059	FMN binding site [chemical binding]; other site
863767007060	NADPH bind site [chemical binding]; other site
863767007061	Helix-turn-helix domain; Region: HTH_17; pfam12728
863767007062	putative heme peroxidase; Provisional; Region: PRK12276
863767007063	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
863767007064	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
863767007065	Walker A/P-loop; other site
863767007066	ATP binding site [chemical binding]; other site
863767007067	Q-loop/lid; other site
863767007068	ABC transporter signature motif; other site
863767007069	Walker B; other site
863767007070	D-loop; other site
863767007071	H-loop/switch region; other site
863767007072	FtsX-like permease family; Region: FtsX; pfam02687
863767007073	FtsX-like permease family; Region: FtsX; pfam02687
863767007074	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767007075	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
863767007076	Coenzyme A binding pocket [chemical binding]; other site
863767007077	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
863767007078	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
863767007079	active site
863767007080	substrate binding site [chemical binding]; other site
863767007081	metal binding site [ion binding]; metal-binding site
863767007082	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
863767007083	YbbR-like protein; Region: YbbR; pfam07949
863767007084	YbbR-like protein; Region: YbbR; pfam07949
863767007085	YbbR-like protein; Region: YbbR; pfam07949
863767007086	Uncharacterized conserved protein [Function unknown]; Region: COG1624
863767007087	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
863767007088	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
863767007089	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
863767007090	Predicted integral membrane protein [Function unknown]; Region: COG5521
863767007091	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
863767007092	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767007093	dimer interface [polypeptide binding]; other site
863767007094	conserved gate region; other site
863767007095	putative PBP binding loops; other site
863767007096	ABC-ATPase subunit interface; other site
863767007097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767007098	dimer interface [polypeptide binding]; other site
863767007099	conserved gate region; other site
863767007100	putative PBP binding loops; other site
863767007101	ABC-ATPase subunit interface; other site
863767007102	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
863767007103	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
863767007104	maltodextrin glucosidase; Provisional; Region: PRK10785
863767007105	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
863767007106	homodimer interface [polypeptide binding]; other site
863767007107	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
863767007108	active site
863767007109	homodimer interface [polypeptide binding]; other site
863767007110	catalytic site [active]
863767007111	CAAX protease self-immunity; Region: Abi; cl00558
863767007112	Transcriptional regulators [Transcription]; Region: PurR; COG1609
863767007113	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
863767007114	DNA binding site [nucleotide binding]
863767007115	domain linker motif; other site
863767007116	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
863767007117	ligand binding site [chemical binding]; other site
863767007118	dimerization interface [polypeptide binding]; other site
863767007119	Amino acid permease; Region: AA_permease_2; pfam13520
863767007120	K+ potassium transporter; Region: K_trans; cl15781
863767007121	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767007122	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
863767007123	ligand binding site [chemical binding]; other site
863767007124	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767007125	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
863767007126	ligand binding site [chemical binding]; other site
863767007127	flexible hinge region; other site
863767007128	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
863767007129	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
863767007130	intersubunit interface [polypeptide binding]; other site
863767007131	active site
863767007132	zinc binding site [ion binding]; other site
863767007133	Na+ binding site [ion binding]; other site
863767007134	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
863767007135	intersubunit interface [polypeptide binding]; other site
863767007136	active site
863767007137	zinc binding site [ion binding]; other site
863767007138	Na+ binding site [ion binding]; other site
863767007139	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
863767007140	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
863767007141	active site
863767007142	P-loop; other site
863767007143	phosphorylation site [posttranslational modification]
863767007144	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767007145	active site
863767007146	phosphorylation site [posttranslational modification]
863767007147	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
863767007148	HTH domain; Region: HTH_11; pfam08279
863767007149	Mga helix-turn-helix domain; Region: Mga; pfam05043
863767007150	PRD domain; Region: PRD; pfam00874
863767007151	PRD domain; Region: PRD; pfam00874
863767007152	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
863767007153	active site
863767007154	P-loop; other site
863767007155	phosphorylation site [posttranslational modification]
863767007156	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
863767007157	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767007158	Walker A/P-loop; other site
863767007159	ATP binding site [chemical binding]; other site
863767007160	Q-loop/lid; other site
863767007161	ABC transporter signature motif; other site
863767007162	Walker B; other site
863767007163	D-loop; other site
863767007164	H-loop/switch region; other site
863767007165	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
863767007166	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
863767007167	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
863767007168	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767007169	Coenzyme A binding pocket [chemical binding]; other site
863767007170	Transcriptional regulators [Transcription]; Region: GntR; COG1802
863767007171	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
863767007172	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
863767007173	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
863767007174	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767007175	DNA-binding site [nucleotide binding]; DNA binding site
863767007176	UTRA domain; Region: UTRA; pfam07702
863767007177	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
863767007178	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
863767007179	Transcriptional regulator [Transcription]; Region: LysR; COG0583
863767007180	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
863767007181	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
863767007182	putative dimerization interface [polypeptide binding]; other site
863767007183	Predicted membrane protein [Function unknown]; Region: COG2855
863767007184	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
863767007185	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
863767007186	putative metal binding site [ion binding]; other site
863767007187	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
863767007188	homodimer interface [polypeptide binding]; other site
863767007189	chemical substrate binding site [chemical binding]; other site
863767007190	oligomer interface [polypeptide binding]; other site
863767007191	metal binding site [ion binding]; metal-binding site
863767007192	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
863767007193	catalytic residues [active]
863767007194	flavodoxin; Provisional; Region: PRK09271
863767007195	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
863767007196	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
863767007197	dimer interface [polypeptide binding]; other site
863767007198	putative radical transfer pathway; other site
863767007199	diiron center [ion binding]; other site
863767007200	tyrosyl radical; other site
863767007201	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209
863767007202	Class I ribonucleotide reductase; Region: RNR_I; cd01679
863767007203	active site
863767007204	dimer interface [polypeptide binding]; other site
863767007205	catalytic residues [active]
863767007206	effector binding site; other site
863767007207	R2 peptide binding site; other site
863767007208	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
863767007209	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
863767007210	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
863767007211	SCP-2 sterol transfer family; Region: SCP2; cl01225
863767007212	CsbD-like; Region: CsbD; cl17424
863767007213	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
863767007214	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
863767007215	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
863767007216	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
863767007217	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
863767007218	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
863767007219	conserved cys residue [active]
863767007220	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
863767007221	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
863767007222	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
863767007223	Cupin; Region: Cupin_1; pfam00190
863767007224	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
863767007225	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
863767007226	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767007227	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767007228	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
863767007229	ligand binding site [chemical binding]; other site
863767007230	flexible hinge region; other site
863767007231	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
863767007232	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
863767007233	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
863767007234	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
863767007235	dimer interface [polypeptide binding]; other site
863767007236	active site
863767007237	metal binding site [ion binding]; metal-binding site
863767007238	glutathione binding site [chemical binding]; other site
863767007239	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
863767007240	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
863767007241	FMN binding site [chemical binding]; other site
863767007242	substrate binding site [chemical binding]; other site
863767007243	putative catalytic residue [active]
863767007244	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
863767007245	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
863767007246	Coenzyme A transferase; Region: CoA_trans; smart00882
863767007247	Coenzyme A transferase; Region: CoA_trans; cl17247
863767007248	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767007249	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
863767007250	Walker A motif; other site
863767007251	ATP binding site [chemical binding]; other site
863767007252	Walker B motif; other site
863767007253	arginine finger; other site
863767007254	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
863767007255	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
863767007256	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
863767007257	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
863767007258	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
863767007259	metal binding site [ion binding]; metal-binding site
863767007260	active site
863767007261	I-site; other site
863767007262	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
863767007263	classical (c) SDRs; Region: SDR_c; cd05233
863767007264	NAD(P) binding site [chemical binding]; other site
863767007265	active site
863767007266	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
863767007267	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
863767007268	Tic20-like protein; Region: Tic20; pfam09685
863767007269	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
863767007270	Cna protein B-type domain; Region: Cna_B; pfam05738
863767007271	Collagen binding domain; Region: Collagen_bind; pfam05737
863767007272	Cna protein B-type domain; Region: Cna_B; pfam05738
863767007273	Cna protein B-type domain; Region: Cna_B; pfam05738
863767007274	Cna protein B-type domain; Region: Cna_B; pfam05738
863767007275	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767007276	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
863767007277	Collagen binding domain; Region: Collagen_bind; pfam05737
863767007278	Cna protein B-type domain; Region: Cna_B; pfam05738
863767007279	Cna protein B-type domain; Region: Cna_B; pfam05738
863767007280	Cna protein B-type domain; Region: Cna_B; pfam05738
863767007281	Cna protein B-type domain; Region: Cna_B; pfam05738
863767007282	Cna protein B-type domain; Region: Cna_B; pfam05738
863767007283	Cna protein B-type domain; Region: Cna_B; pfam05738
863767007284	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767007285	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767007286	Cna protein B-type domain; Region: Cna_B; pfam05738
863767007287	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767007288	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767007289	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767007290	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
863767007291	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
863767007292	active site
863767007293	catalytic site [active]
863767007294	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
863767007295	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
863767007296	Walker A/P-loop; other site
863767007297	ATP binding site [chemical binding]; other site
863767007298	Q-loop/lid; other site
863767007299	ABC transporter signature motif; other site
863767007300	Walker B; other site
863767007301	D-loop; other site
863767007302	H-loop/switch region; other site
863767007303	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
863767007304	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
863767007305	ABC-ATPase subunit  interface; other site
863767007306	dimer interface [polypeptide binding]; other site
863767007307	putative PBP binding regions; other site
863767007308	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
863767007309	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
863767007310	intersubunit interface [polypeptide binding]; other site
863767007311	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
863767007312	heme-binding site [chemical binding]; other site
863767007313	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
863767007314	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
863767007315	heme-binding site [chemical binding]; other site
863767007316	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
863767007317	heme-binding site [chemical binding]; other site
863767007318	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
863767007319	heme uptake protein IsdC; Region: IsdC; TIGR03656
863767007320	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
863767007321	heme-binding site [chemical binding]; other site
863767007322	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
863767007323	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
863767007324	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
863767007325	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
863767007326	active site
863767007327	Zn binding site [ion binding]; other site
863767007328	Competence protein CoiA-like family; Region: CoiA; cl11541
863767007329	Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862
863767007330	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
863767007331	ArsC family; Region: ArsC; pfam03960
863767007332	putative catalytic residues [active]
863767007333	thiol/disulfide switch; other site
863767007334	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
863767007335	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
863767007336	Walker A/P-loop; other site
863767007337	ATP binding site [chemical binding]; other site
863767007338	Q-loop/lid; other site
863767007339	ABC transporter signature motif; other site
863767007340	Walker B; other site
863767007341	D-loop; other site
863767007342	H-loop/switch region; other site
863767007343	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
863767007344	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
863767007345	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
863767007346	Walker A/P-loop; other site
863767007347	ATP binding site [chemical binding]; other site
863767007348	Q-loop/lid; other site
863767007349	ABC transporter signature motif; other site
863767007350	Walker B; other site
863767007351	D-loop; other site
863767007352	H-loop/switch region; other site
863767007353	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
863767007354	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
863767007355	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767007356	dimer interface [polypeptide binding]; other site
863767007357	conserved gate region; other site
863767007358	putative PBP binding loops; other site
863767007359	ABC-ATPase subunit interface; other site
863767007360	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
863767007361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767007362	dimer interface [polypeptide binding]; other site
863767007363	conserved gate region; other site
863767007364	putative PBP binding loops; other site
863767007365	ABC-ATPase subunit interface; other site
863767007366	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
863767007367	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
863767007368	peptide binding site [polypeptide binding]; other site
863767007369	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
863767007370	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
863767007371	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
863767007372	active site
863767007373	HIGH motif; other site
863767007374	dimer interface [polypeptide binding]; other site
863767007375	KMSKS motif; other site
863767007376	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
863767007377	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
863767007378	MarR family; Region: MarR; pfam01047
863767007379	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
863767007380	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
863767007381	dimer interface [polypeptide binding]; other site
863767007382	active site
863767007383	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
863767007384	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
863767007385	dimer interface [polypeptide binding]; other site
863767007386	active site
863767007387	CoA binding pocket [chemical binding]; other site
863767007388	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
863767007389	SH3-like domain; Region: SH3_8; pfam13457
863767007390	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
863767007391	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
863767007392	catalytic core [active]
863767007393	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
863767007394	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
863767007395	Clp amino terminal domain; Region: Clp_N; pfam02861
863767007396	Clp amino terminal domain; Region: Clp_N; pfam02861
863767007397	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767007398	Walker A motif; other site
863767007399	ATP binding site [chemical binding]; other site
863767007400	Walker B motif; other site
863767007401	arginine finger; other site
863767007402	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767007403	Walker A motif; other site
863767007404	ATP binding site [chemical binding]; other site
863767007405	Walker B motif; other site
863767007406	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
863767007407	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
863767007408	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
863767007409	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
863767007410	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767007411	active site
863767007412	motif I; other site
863767007413	motif II; other site
863767007414	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
863767007415	Predicted acetyltransferase [General function prediction only]; Region: COG3393
863767007416	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
863767007417	ferrochelatase; Provisional; Region: PRK12435
863767007418	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
863767007419	C-terminal domain interface [polypeptide binding]; other site
863767007420	active site
863767007421	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
863767007422	active site
863767007423	N-terminal domain interface [polypeptide binding]; other site
863767007424	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
863767007425	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
863767007426	substrate binding site [chemical binding]; other site
863767007427	active site
863767007428	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
863767007429	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
863767007430	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
863767007431	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
863767007432	Walker A/P-loop; other site
863767007433	ATP binding site [chemical binding]; other site
863767007434	Q-loop/lid; other site
863767007435	ABC transporter signature motif; other site
863767007436	Walker B; other site
863767007437	D-loop; other site
863767007438	H-loop/switch region; other site
863767007439	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
863767007440	HIT family signature motif; other site
863767007441	catalytic residue [active]
863767007442	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
863767007443	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
863767007444	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
863767007445	SurA N-terminal domain; Region: SurA_N_3; cl07813
863767007446	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
863767007447	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
863767007448	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
863767007449	generic binding surface II; other site
863767007450	generic binding surface I; other site
863767007451	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
863767007452	Zn2+ binding site [ion binding]; other site
863767007453	Mg2+ binding site [ion binding]; other site
863767007454	Uncharacterized conserved protein [Function unknown]; Region: COG4717
863767007455	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
863767007456	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
863767007457	active site
863767007458	metal binding site [ion binding]; metal-binding site
863767007459	DNA binding site [nucleotide binding]
863767007460	hypothetical protein; Provisional; Region: PRK13676
863767007461	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
863767007462	fumarate hydratase; Reviewed; Region: fumC; PRK00485
863767007463	Class II fumarases; Region: Fumarase_classII; cd01362
863767007464	active site
863767007465	tetramer interface [polypeptide binding]; other site
863767007466	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
863767007467	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
863767007468	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
863767007469	Walker A/P-loop; other site
863767007470	ATP binding site [chemical binding]; other site
863767007471	Q-loop/lid; other site
863767007472	ABC transporter signature motif; other site
863767007473	Walker B; other site
863767007474	D-loop; other site
863767007475	H-loop/switch region; other site
863767007476	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
863767007477	Transglycosylase; Region: Transgly; pfam00912
863767007478	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
863767007479	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
863767007480	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
863767007481	Low molecular weight phosphatase family; Region: LMWPc; cl00105
863767007482	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
863767007483	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
863767007484	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
863767007485	Domain of unknown function DUF21; Region: DUF21; pfam01595
863767007486	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
863767007487	Transporter associated domain; Region: CorC_HlyC; smart01091
863767007488	Transcriptional regulator [Transcription]; Region: LysR; COG0583
863767007489	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
863767007490	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
863767007491	putative dimerization interface [polypeptide binding]; other site
863767007492	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
863767007493	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
863767007494	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
863767007495	active site
863767007496	FMN binding site [chemical binding]; other site
863767007497	substrate binding site [chemical binding]; other site
863767007498	putative catalytic residue [active]
863767007499	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
863767007500	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
863767007501	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
863767007502	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
863767007503	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
863767007504	shikimate binding site; other site
863767007505	NAD(P) binding site [chemical binding]; other site
863767007506	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767007507	putative substrate translocation pore; other site
863767007508	Major Facilitator Superfamily; Region: MFS_1; pfam07690
863767007509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767007510	Major Facilitator Superfamily; Region: MFS_1; pfam07690
863767007511	putative substrate translocation pore; other site
863767007512	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
863767007513	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
863767007514	Walker A/P-loop; other site
863767007515	ATP binding site [chemical binding]; other site
863767007516	Q-loop/lid; other site
863767007517	ABC transporter signature motif; other site
863767007518	Walker B; other site
863767007519	D-loop; other site
863767007520	H-loop/switch region; other site
863767007521	Predicted transcriptional regulators [Transcription]; Region: COG1725
863767007522	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
863767007523	DNA-binding site [nucleotide binding]; DNA binding site
863767007524	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
863767007525	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
863767007526	DNA binding site [nucleotide binding]
863767007527	active site
863767007528	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
863767007529	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
863767007530	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
863767007531	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
863767007532	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
863767007533	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
863767007534	active site
863767007535	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
863767007536	putative dimer interface [polypeptide binding]; other site
863767007537	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
863767007538	ligand binding site [chemical binding]; other site
863767007539	Zn binding site [ion binding]; other site
863767007540	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
863767007541	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
863767007542	active site
863767007543	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
863767007544	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
863767007545	active site
863767007546	catalytic tetrad [active]
863767007547	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
863767007548	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
863767007549	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
863767007550	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
863767007551	substrate binding pocket [chemical binding]; other site
863767007552	membrane-bound complex binding site; other site
863767007553	hinge residues; other site
863767007554	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
863767007555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767007556	dimer interface [polypeptide binding]; other site
863767007557	conserved gate region; other site
863767007558	putative PBP binding loops; other site
863767007559	ABC-ATPase subunit interface; other site
863767007560	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
863767007561	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
863767007562	Walker A/P-loop; other site
863767007563	ATP binding site [chemical binding]; other site
863767007564	Q-loop/lid; other site
863767007565	ABC transporter signature motif; other site
863767007566	Walker B; other site
863767007567	D-loop; other site
863767007568	H-loop/switch region; other site
863767007569	aspartate aminotransferase; Provisional; Region: PRK06348
863767007570	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
863767007571	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767007572	homodimer interface [polypeptide binding]; other site
863767007573	catalytic residue [active]
863767007574	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
863767007575	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767007576	motif II; other site
863767007577	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
863767007578	intracellular protease, PfpI family; Region: PfpI; TIGR01382
863767007579	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
863767007580	proposed catalytic triad [active]
863767007581	conserved cys residue [active]
863767007582	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
863767007583	methionine cluster; other site
863767007584	active site
863767007585	phosphorylation site [posttranslational modification]
863767007586	metal binding site [ion binding]; metal-binding site
863767007587	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767007588	Coenzyme A binding pocket [chemical binding]; other site
863767007589	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
863767007590	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
863767007591	esterase; Provisional; Region: PRK10566
863767007592	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
863767007593	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
863767007594	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767007595	Uncharacterized conserved protein [Function unknown]; Region: COG1284
863767007596	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
863767007597	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
863767007598	hypothetical protein; Provisional; Region: PRK13673
863767007599	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
863767007600	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
863767007601	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
863767007602	Part of AAA domain; Region: AAA_19; pfam13245
863767007603	Family description; Region: UvrD_C_2; pfam13538
863767007604	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
863767007605	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
863767007606	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
863767007607	IDEAL domain; Region: IDEAL; pfam08858
863767007608	ComK protein; Region: ComK; cl11560
863767007609	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
863767007610	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767007611	non-specific DNA binding site [nucleotide binding]; other site
863767007612	salt bridge; other site
863767007613	sequence-specific DNA binding site [nucleotide binding]; other site
863767007614	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
863767007615	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767007616	active site
863767007617	phosphorylation site [posttranslational modification]
863767007618	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
863767007619	active site
863767007620	P-loop; other site
863767007621	phosphorylation site [posttranslational modification]
863767007622	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
863767007623	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
863767007624	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
863767007625	putative substrate binding site [chemical binding]; other site
863767007626	putative ATP binding site [chemical binding]; other site
863767007627	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
863767007628	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
863767007629	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
863767007630	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
863767007631	trimer interface [polypeptide binding]; other site
863767007632	active site
863767007633	G bulge; other site
863767007634	Uncharacterized conserved protein [Function unknown]; Region: COG1683
863767007635	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
863767007636	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
863767007637	non-specific DNA interactions [nucleotide binding]; other site
863767007638	DNA binding site [nucleotide binding]
863767007639	sequence specific DNA binding site [nucleotide binding]; other site
863767007640	putative cAMP binding site [chemical binding]; other site
863767007641	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
863767007642	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
863767007643	substrate binding site [chemical binding]; other site
863767007644	ATP binding site [chemical binding]; other site
863767007645	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
863767007646	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
863767007647	RNA binding surface [nucleotide binding]; other site
863767007648	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
863767007649	active site
863767007650	uracil binding [chemical binding]; other site
863767007651	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
863767007652	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
863767007653	active site
863767007654	non-prolyl cis peptide bond; other site
863767007655	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
863767007656	catalytic residues [active]
863767007657	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
863767007658	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
863767007659	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
863767007660	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
863767007661	Walker A/P-loop; other site
863767007662	ATP binding site [chemical binding]; other site
863767007663	Q-loop/lid; other site
863767007664	ABC transporter signature motif; other site
863767007665	Walker B; other site
863767007666	D-loop; other site
863767007667	H-loop/switch region; other site
863767007668	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
863767007669	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767007670	dimer interface [polypeptide binding]; other site
863767007671	conserved gate region; other site
863767007672	putative PBP binding loops; other site
863767007673	ABC-ATPase subunit interface; other site
863767007674	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
863767007675	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767007676	dimer interface [polypeptide binding]; other site
863767007677	conserved gate region; other site
863767007678	putative PBP binding loops; other site
863767007679	ABC-ATPase subunit interface; other site
863767007680	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
863767007681	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
863767007682	substrate binding pocket [chemical binding]; other site
863767007683	membrane-bound complex binding site; other site
863767007684	hinge residues; other site
863767007685	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767007686	Coenzyme A binding pocket [chemical binding]; other site
863767007687	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
863767007688	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
863767007689	Transcriptional regulator [Transcription]; Region: LysR; COG0583
863767007690	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
863767007691	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
863767007692	dimerization interface [polypeptide binding]; other site
863767007693	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
863767007694	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
863767007695	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
863767007696	active site
863767007697	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767007698	Major Facilitator Superfamily; Region: MFS_1; pfam07690
863767007699	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767007700	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
863767007701	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
863767007702	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
863767007703	active site
863767007704	trimer interface [polypeptide binding]; other site
863767007705	allosteric site; other site
863767007706	active site lid [active]
863767007707	hexamer (dimer of trimers) interface [polypeptide binding]; other site
863767007708	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
863767007709	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
863767007710	Predicted membrane protein [Function unknown]; Region: COG1511
863767007711	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
863767007712	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
863767007713	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
863767007714	Predicted transcriptional regulator [Transcription]; Region: COG1959
863767007715	Transcriptional regulator; Region: Rrf2; pfam02082
863767007716	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
863767007717	L-tyrosine decarboxylase; Provisional; Region: PRK13520
863767007718	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
863767007719	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767007720	catalytic residue [active]
863767007721	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
863767007722	Mga helix-turn-helix domain; Region: Mga; pfam05043
863767007723	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
863767007724	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
863767007725	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
863767007726	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
863767007727	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
863767007728	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
863767007729	active site
863767007730	dimer interface [polypeptide binding]; other site
863767007731	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
863767007732	dimer interface [polypeptide binding]; other site
863767007733	active site
863767007734	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
863767007735	nudix motif; other site
863767007736	general stress protein 13; Validated; Region: PRK08059
863767007737	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
863767007738	RNA binding site [nucleotide binding]; other site
863767007739	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
863767007740	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
863767007741	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767007742	homodimer interface [polypeptide binding]; other site
863767007743	catalytic residue [active]
863767007744	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
863767007745	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
863767007746	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
863767007747	Walker A/P-loop; other site
863767007748	ATP binding site [chemical binding]; other site
863767007749	Q-loop/lid; other site
863767007750	ABC transporter signature motif; other site
863767007751	Walker B; other site
863767007752	D-loop; other site
863767007753	H-loop/switch region; other site
863767007754	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
863767007755	active site
863767007756	P-loop; other site
863767007757	phosphorylation site [posttranslational modification]
863767007758	aspartate kinase; Reviewed; Region: PRK09034
863767007759	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
863767007760	putative catalytic residues [active]
863767007761	putative nucleotide binding site [chemical binding]; other site
863767007762	putative aspartate binding site [chemical binding]; other site
863767007763	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
863767007764	allosteric regulatory residue; other site
863767007765	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
863767007766	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
863767007767	active site
863767007768	drug efflux system protein MdtG; Provisional; Region: PRK09874
863767007769	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767007770	putative substrate translocation pore; other site
863767007771	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
863767007772	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
863767007773	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
863767007774	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
863767007775	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
863767007776	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
863767007777	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
863767007778	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
863767007779	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
863767007780	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585
863767007781	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
863767007782	CoenzymeA binding site [chemical binding]; other site
863767007783	subunit interaction site [polypeptide binding]; other site
863767007784	PHB binding site; other site
863767007785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963
863767007786	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
863767007787	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
863767007788	Cl- selectivity filter; other site
863767007789	Cl- binding residues [ion binding]; other site
863767007790	pore gating glutamate residue; other site
863767007791	dimer interface [polypeptide binding]; other site
863767007792	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767007793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
863767007794	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
863767007795	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
863767007796	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
863767007797	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
863767007798	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
863767007799	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
863767007800	NADH(P)-binding; Region: NAD_binding_10; pfam13460
863767007801	NAD(P) binding site [chemical binding]; other site
863767007802	putative active site [active]
863767007803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844
863767007804	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
863767007805	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
863767007806	Leucine-rich repeats; other site
863767007807	Substrate binding site [chemical binding]; other site
863767007808	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767007809	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767007810	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767007811	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767007812	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767007813	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767007814	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767007815	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767007816	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767007817	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
863767007818	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
863767007819	tetramer interfaces [polypeptide binding]; other site
863767007820	binuclear metal-binding site [ion binding]; other site
863767007821	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
863767007822	Domain of unknown function DUF21; Region: DUF21; pfam01595
863767007823	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
863767007824	Transporter associated domain; Region: CorC_HlyC; smart01091
863767007825	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
863767007826	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767007827	Coenzyme A binding pocket [chemical binding]; other site
863767007828	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
863767007829	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767007830	active site
863767007831	motif I; other site
863767007832	motif II; other site
863767007833	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767007834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
863767007835	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
863767007836	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
863767007837	active site
863767007838	metal binding site [ion binding]; metal-binding site
863767007839	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
863767007840	Predicted permeases [General function prediction only]; Region: COG0730
863767007841	Predicted membrane protein [Function unknown]; Region: COG4272
863767007842	Uncharacterized conserved protein [Function unknown]; Region: COG1801
863767007843	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
863767007844	FeS assembly protein SufB; Region: sufB; TIGR01980
863767007845	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
863767007846	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
863767007847	trimerization site [polypeptide binding]; other site
863767007848	active site
863767007849	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
863767007850	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
863767007851	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
863767007852	catalytic residue [active]
863767007853	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
863767007854	FeS assembly protein SufD; Region: sufD; TIGR01981
863767007855	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
863767007856	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
863767007857	Walker A/P-loop; other site
863767007858	ATP binding site [chemical binding]; other site
863767007859	Q-loop/lid; other site
863767007860	ABC transporter signature motif; other site
863767007861	Walker B; other site
863767007862	D-loop; other site
863767007863	H-loop/switch region; other site
863767007864	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
863767007865	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
863767007866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767007867	ABC-ATPase subunit interface; other site
863767007868	putative PBP binding loops; other site
863767007869	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
863767007870	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
863767007871	Walker A/P-loop; other site
863767007872	ATP binding site [chemical binding]; other site
863767007873	Q-loop/lid; other site
863767007874	ABC transporter signature motif; other site
863767007875	Walker B; other site
863767007876	D-loop; other site
863767007877	H-loop/switch region; other site
863767007878	NIL domain; Region: NIL; pfam09383
863767007879	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
863767007880	dimer interface [polypeptide binding]; other site
863767007881	phosphorylation site [posttranslational modification]
863767007882	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767007883	ATP binding site [chemical binding]; other site
863767007884	Mg2+ binding site [ion binding]; other site
863767007885	G-X-G motif; other site
863767007886	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
863767007887	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767007888	active site
863767007889	phosphorylation site [posttranslational modification]
863767007890	intermolecular recognition site; other site
863767007891	dimerization interface [polypeptide binding]; other site
863767007892	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
863767007893	DNA binding site [nucleotide binding]
863767007894	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
863767007895	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
863767007896	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
863767007897	catalytic residues [active]
863767007898	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
863767007899	lipoyl attachment site [posttranslational modification]; other site
863767007900	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
863767007901	ArsC family; Region: ArsC; pfam03960
863767007902	putative ArsC-like catalytic residues; other site
863767007903	putative TRX-like catalytic residues [active]
863767007904	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
863767007905	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
863767007906	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
863767007907	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
863767007908	Walker A/P-loop; other site
863767007909	ATP binding site [chemical binding]; other site
863767007910	Q-loop/lid; other site
863767007911	ABC transporter signature motif; other site
863767007912	Walker B; other site
863767007913	D-loop; other site
863767007914	H-loop/switch region; other site
863767007915	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
863767007916	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
863767007917	ABC-ATPase subunit  interface; other site
863767007918	dimer interface [polypeptide binding]; other site
863767007919	putative PBP binding regions; other site
863767007920	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
863767007921	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
863767007922	intersubunit interface [polypeptide binding]; other site
863767007923	Predicted esterase [General function prediction only]; Region: COG0627
863767007924	S-formylglutathione hydrolase; Region: PLN02442
863767007925	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
863767007926	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767007927	catalytic residue [active]
863767007928	SdpI/YhfL protein family; Region: SdpI; pfam13630
863767007929	CAT RNA binding domain; Region: CAT_RBD; smart01061
863767007930	transcriptional antiterminator BglG; Provisional; Region: PRK09772
863767007931	PRD domain; Region: PRD; pfam00874
863767007932	PRD domain; Region: PRD; pfam00874
863767007933	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
863767007934	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
863767007935	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
863767007936	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
863767007937	Predicted transcriptional regulator [Transcription]; Region: COG2378
863767007938	HTH domain; Region: HTH_11; pfam08279
863767007939	WYL domain; Region: WYL; pfam13280
863767007940	Uncharacterized conserved protein [Function unknown]; Region: COG1434
863767007941	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
863767007942	putative active site [active]
863767007943	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
863767007944	Leucine rich repeat; Region: LRR_8; pfam13855
863767007945	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
863767007946	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
863767007947	active site
863767007948	catalytic site [active]
863767007949	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
863767007950	putative metal binding site [ion binding]; other site
863767007951	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
863767007952	putative metal binding site [ion binding]; other site
863767007953	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
863767007954	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
863767007955	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
863767007956	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
863767007957	active site
863767007958	catalytic site [active]
863767007959	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
863767007960	putative metal binding site [ion binding]; other site
863767007961	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767007962	non-specific DNA binding site [nucleotide binding]; other site
863767007963	salt bridge; other site
863767007964	sequence-specific DNA binding site [nucleotide binding]; other site
863767007965	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
863767007966	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
863767007967	SmpB-tmRNA interface; other site
863767007968	ribonuclease R; Region: RNase_R; TIGR02063
863767007969	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
863767007970	RNB domain; Region: RNB; pfam00773
863767007971	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
863767007972	RNA binding site [nucleotide binding]; other site
863767007973	Esterase/lipase [General function prediction only]; Region: COG1647
863767007974	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
863767007975	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
863767007976	Preprotein translocase SecG subunit; Region: SecG; cl09123
863767007977	Esterase/lipase [General function prediction only]; Region: COG1647
863767007978	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
863767007979	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
863767007980	PGAP1-like protein; Region: PGAP1; pfam07819
863767007981	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
863767007982	enolase; Provisional; Region: eno; PRK00077
863767007983	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
863767007984	dimer interface [polypeptide binding]; other site
863767007985	metal binding site [ion binding]; metal-binding site
863767007986	substrate binding pocket [chemical binding]; other site
863767007987	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
863767007988	phosphoglyceromutase; Provisional; Region: PRK05434
863767007989	triosephosphate isomerase; Provisional; Region: PRK14567
863767007990	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
863767007991	substrate binding site [chemical binding]; other site
863767007992	dimer interface [polypeptide binding]; other site
863767007993	catalytic triad [active]
863767007994	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
863767007995	Phosphoglycerate kinase; Region: PGK; pfam00162
863767007996	substrate binding site [chemical binding]; other site
863767007997	hinge regions; other site
863767007998	ADP binding site [chemical binding]; other site
863767007999	catalytic site [active]
863767008000	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
863767008001	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
863767008002	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
863767008003	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
863767008004	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
863767008005	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
863767008006	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
863767008007	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
863767008008	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
863767008009	DNA binding site [nucleotide binding]
863767008010	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
863767008011	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
863767008012	active site
863767008013	dimer interface [polypeptide binding]; other site
863767008014	MMPL family; Region: MMPL; pfam03176
863767008015	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
863767008016	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
863767008017	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
863767008018	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
863767008019	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
863767008020	Chitin binding domain; Region: Chitin_bind_3; pfam03067
863767008021	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
863767008022	Interdomain contacts; other site
863767008023	Cytokine receptor motif; other site
863767008024	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
863767008025	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
863767008026	Interdomain contacts; other site
863767008027	Cytokine receptor motif; other site
863767008028	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
863767008029	aromatic chitin/cellulose binding site residues [chemical binding]; other site
863767008030	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
863767008031	aromatic chitin/cellulose binding site residues [chemical binding]; other site
863767008032	Clp protease; Region: CLP_protease; pfam00574
863767008033	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
863767008034	oligomer interface [polypeptide binding]; other site
863767008035	active site residues [active]
863767008036	amino acid transporter; Region: 2A0306; TIGR00909
863767008037	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
863767008038	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
863767008039	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
863767008040	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767008041	Substrate binding site [chemical binding]; other site
863767008042	Leucine rich repeat; Region: LRR_8; pfam13855
863767008043	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767008044	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
863767008045	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
863767008046	active site
863767008047	FMN binding site [chemical binding]; other site
863767008048	substrate binding site [chemical binding]; other site
863767008049	homotetramer interface [polypeptide binding]; other site
863767008050	catalytic residue [active]
863767008051	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
863767008052	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
863767008053	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
863767008054	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
863767008055	phosphate binding site [ion binding]; other site
863767008056	putative substrate binding pocket [chemical binding]; other site
863767008057	dimer interface [polypeptide binding]; other site
863767008058	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
863767008059	AAA domain; Region: AAA_18; pfam13238
863767008060	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
863767008061	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
863767008062	active site
863767008063	substrate binding site [chemical binding]; other site
863767008064	metal binding site [ion binding]; metal-binding site
863767008065	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
863767008066	active site
863767008067	catalytic residues [active]
863767008068	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
863767008069	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
863767008070	NAD binding site [chemical binding]; other site
863767008071	homodimer interface [polypeptide binding]; other site
863767008072	active site
863767008073	substrate binding site [chemical binding]; other site
863767008074	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
863767008075	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
863767008076	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
863767008077	TPR repeat; Region: TPR_11; pfam13414
863767008078	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
863767008079	binding surface
863767008080	TPR motif; other site
863767008081	Tetratricopeptide repeat; Region: TPR_12; pfam13424
863767008082	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
863767008083	binding surface
863767008084	TPR motif; other site
863767008085	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
863767008086	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
863767008087	putative trimer interface [polypeptide binding]; other site
863767008088	putative CoA binding site [chemical binding]; other site
863767008089	pyrophosphatase PpaX; Provisional; Region: PRK13288
863767008090	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767008091	motif II; other site
863767008092	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
863767008093	HPr kinase/phosphorylase; Provisional; Region: PRK05428
863767008094	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
863767008095	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
863767008096	Hpr binding site; other site
863767008097	active site
863767008098	homohexamer subunit interaction site [polypeptide binding]; other site
863767008099	Predicted membrane protein [Function unknown]; Region: COG1950
863767008100	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
863767008101	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
863767008102	Uncharacterized conserved protein [Function unknown]; Region: COG3595
863767008103	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
863767008104	Uncharacterized conserved protein [Function unknown]; Region: COG3595
863767008105	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
863767008106	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
863767008107	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
863767008108	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
863767008109	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
863767008110	excinuclease ABC subunit B; Provisional; Region: PRK05298
863767008111	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
863767008112	ATP binding site [chemical binding]; other site
863767008113	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
863767008114	nucleotide binding region [chemical binding]; other site
863767008115	ATP-binding site [chemical binding]; other site
863767008116	Ultra-violet resistance protein B; Region: UvrB; pfam12344
863767008117	UvrB/uvrC motif; Region: UVR; pfam02151
863767008118	Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559
863767008119	HD containing hydrolase-like enzyme; Region: HD_2; pfam12917
863767008120	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
863767008121	dimerization interface [polypeptide binding]; other site
863767008122	putative DNA binding site [nucleotide binding]; other site
863767008123	putative Zn2+ binding site [ion binding]; other site
863767008124	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
863767008125	PhoU domain; Region: PhoU; pfam01895
863767008126	PhoU domain; Region: PhoU; pfam01895
863767008127	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
863767008128	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
863767008129	Walker A/P-loop; other site
863767008130	ATP binding site [chemical binding]; other site
863767008131	Q-loop/lid; other site
863767008132	ABC transporter signature motif; other site
863767008133	Walker B; other site
863767008134	D-loop; other site
863767008135	H-loop/switch region; other site
863767008136	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
863767008137	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
863767008138	Walker A/P-loop; other site
863767008139	ATP binding site [chemical binding]; other site
863767008140	Q-loop/lid; other site
863767008141	ABC transporter signature motif; other site
863767008142	Walker B; other site
863767008143	D-loop; other site
863767008144	H-loop/switch region; other site
863767008145	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
863767008146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767008147	dimer interface [polypeptide binding]; other site
863767008148	conserved gate region; other site
863767008149	putative PBP binding loops; other site
863767008150	ABC-ATPase subunit interface; other site
863767008151	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
863767008152	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767008153	dimer interface [polypeptide binding]; other site
863767008154	conserved gate region; other site
863767008155	putative PBP binding loops; other site
863767008156	ABC-ATPase subunit interface; other site
863767008157	PBP superfamily domain; Region: PBP_like_2; cl17296
863767008158	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
863767008159	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
863767008160	HAMP domain; Region: HAMP; pfam00672
863767008161	dimerization interface [polypeptide binding]; other site
863767008162	PAS domain; Region: PAS; smart00091
863767008163	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
863767008164	dimer interface [polypeptide binding]; other site
863767008165	phosphorylation site [posttranslational modification]
863767008166	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767008167	ATP binding site [chemical binding]; other site
863767008168	Mg2+ binding site [ion binding]; other site
863767008169	G-X-G motif; other site
863767008170	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
863767008171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767008172	active site
863767008173	phosphorylation site [posttranslational modification]
863767008174	intermolecular recognition site; other site
863767008175	dimerization interface [polypeptide binding]; other site
863767008176	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
863767008177	DNA binding site [nucleotide binding]
863767008178	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
863767008179	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
863767008180	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
863767008181	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
863767008182	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
863767008183	putative active site [active]
863767008184	catalytic site [active]
863767008185	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
863767008186	putative active site [active]
863767008187	catalytic site [active]
863767008188	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
863767008189	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
863767008190	Peptidase family M23; Region: Peptidase_M23; pfam01551
863767008191	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
863767008192	NlpC/P60 family; Region: NLPC_P60; pfam00877
863767008193	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
863767008194	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
863767008195	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
863767008196	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767008197	Walker A/P-loop; other site
863767008198	ATP binding site [chemical binding]; other site
863767008199	Q-loop/lid; other site
863767008200	ABC transporter signature motif; other site
863767008201	Walker B; other site
863767008202	D-loop; other site
863767008203	H-loop/switch region; other site
863767008204	Uncharacterized conserved protein [Function unknown]; Region: COG1284
863767008205	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
863767008206	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
863767008207	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
863767008208	peptide chain release factor 2; Validated; Region: prfB; PRK00578
863767008209	This domain is found in peptide chain release factors; Region: PCRF; smart00937
863767008210	RF-1 domain; Region: RF-1; pfam00472
863767008211	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
863767008212	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
863767008213	nucleotide binding region [chemical binding]; other site
863767008214	helicase superfamily c-terminal domain; Region: HELICc; smart00490
863767008215	ATP-binding site [chemical binding]; other site
863767008216	SEC-C motif; Region: SEC-C; pfam02810
863767008217	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
863767008218	30S subunit binding site; other site
863767008219	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
863767008220	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
863767008221	active site
863767008222	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
863767008223	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
863767008224	ATP binding site [chemical binding]; other site
863767008225	putative Mg++ binding site [ion binding]; other site
863767008226	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
863767008227	nucleotide binding region [chemical binding]; other site
863767008228	ATP-binding site [chemical binding]; other site
863767008229	EDD domain protein, DegV family; Region: DegV; TIGR00762
863767008230	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
863767008231	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
863767008232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767008233	active site
863767008234	phosphorylation site [posttranslational modification]
863767008235	intermolecular recognition site; other site
863767008236	dimerization interface [polypeptide binding]; other site
863767008237	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
863767008238	DNA binding residues [nucleotide binding]
863767008239	dimerization interface [polypeptide binding]; other site
863767008240	Uncharacterized conserved protein [Function unknown]; Region: COG1739
863767008241	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
863767008242	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
863767008243	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
863767008244	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
863767008245	Transcriptional regulator [Transcription]; Region: LytR; COG1316
863767008246	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
863767008247	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
863767008248	Mg++ binding site [ion binding]; other site
863767008249	putative catalytic motif [active]
863767008250	substrate binding site [chemical binding]; other site
863767008251	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
863767008252	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
863767008253	active site
863767008254	octamer interface [polypeptide binding]; other site
863767008255	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
863767008256	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
863767008257	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
863767008258	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
863767008259	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
863767008260	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
863767008261	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
863767008262	dimer interface [polypeptide binding]; other site
863767008263	ssDNA binding site [nucleotide binding]; other site
863767008264	tetramer (dimer of dimers) interface [polypeptide binding]; other site
863767008265	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
863767008266	rod shape-determining protein Mbl; Provisional; Region: PRK13928
863767008267	MreB and similar proteins; Region: MreB_like; cd10225
863767008268	nucleotide binding site [chemical binding]; other site
863767008269	Mg binding site [ion binding]; other site
863767008270	putative protofilament interaction site [polypeptide binding]; other site
863767008271	RodZ interaction site [polypeptide binding]; other site
863767008272	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
863767008273	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
863767008274	hinge; other site
863767008275	active site
863767008276	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
863767008277	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
863767008278	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
863767008279	gamma subunit interface [polypeptide binding]; other site
863767008280	epsilon subunit interface [polypeptide binding]; other site
863767008281	LBP interface [polypeptide binding]; other site
863767008282	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
863767008283	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
863767008284	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
863767008285	alpha subunit interaction interface [polypeptide binding]; other site
863767008286	Walker A motif; other site
863767008287	ATP binding site [chemical binding]; other site
863767008288	Walker B motif; other site
863767008289	inhibitor binding site; inhibition site
863767008290	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
863767008291	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
863767008292	core domain interface [polypeptide binding]; other site
863767008293	delta subunit interface [polypeptide binding]; other site
863767008294	epsilon subunit interface [polypeptide binding]; other site
863767008295	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
863767008296	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
863767008297	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
863767008298	beta subunit interaction interface [polypeptide binding]; other site
863767008299	Walker A motif; other site
863767008300	ATP binding site [chemical binding]; other site
863767008301	Walker B motif; other site
863767008302	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
863767008303	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
863767008304	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
863767008305	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
863767008306	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
863767008307	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
863767008308	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
863767008309	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
863767008310	ATP synthase I chain; Region: ATP_synt_I; pfam03899
863767008311	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
863767008312	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
863767008313	active site
863767008314	homodimer interface [polypeptide binding]; other site
863767008315	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
863767008316	active site
863767008317	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
863767008318	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
863767008319	dimer interface [polypeptide binding]; other site
863767008320	active site
863767008321	glycine-pyridoxal phosphate binding site [chemical binding]; other site
863767008322	folate binding site [chemical binding]; other site
863767008323	Low molecular weight phosphatase family; Region: LMWPc; cd00115
863767008324	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
863767008325	active site
863767008326	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
863767008327	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
863767008328	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
863767008329	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767008330	S-adenosylmethionine binding site [chemical binding]; other site
863767008331	peptide chain release factor 1; Validated; Region: prfA; PRK00591
863767008332	This domain is found in peptide chain release factors; Region: PCRF; smart00937
863767008333	RF-1 domain; Region: RF-1; pfam00472
863767008334	thymidine kinase; Provisional; Region: PRK04296
863767008335	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
863767008336	ATP binding site [chemical binding]; other site
863767008337	Walker A motif; other site
863767008338	Walker B motif; other site
863767008339	homoserine kinase; Provisional; Region: PRK01212
863767008340	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
863767008341	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
863767008342	threonine synthase; Reviewed; Region: PRK06721
863767008343	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
863767008344	homodimer interface [polypeptide binding]; other site
863767008345	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767008346	catalytic residue [active]
863767008347	homoserine dehydrogenase; Provisional; Region: PRK06349
863767008348	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
863767008349	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
863767008350	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
863767008351	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
863767008352	Predicted membrane protein [Function unknown]; Region: COG2246
863767008353	GtrA-like protein; Region: GtrA; pfam04138
863767008354	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
863767008355	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
863767008356	Ligand binding site; other site
863767008357	Putative Catalytic site; other site
863767008358	DXD motif; other site
863767008359	transcription termination factor Rho; Provisional; Region: rho; PRK09376
863767008360	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
863767008361	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
863767008362	RNA binding site [nucleotide binding]; other site
863767008363	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
863767008364	multimer interface [polypeptide binding]; other site
863767008365	Walker A motif; other site
863767008366	ATP binding site [chemical binding]; other site
863767008367	Walker B motif; other site
863767008368	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
863767008369	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
863767008370	hinge; other site
863767008371	active site
863767008372	Predicted integral membrane protein [Function unknown]; Region: COG0392
863767008373	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
863767008374	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
863767008375	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
863767008376	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
863767008377	putative ADP-binding pocket [chemical binding]; other site
863767008378	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
863767008379	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
863767008380	intersubunit interface [polypeptide binding]; other site
863767008381	active site
863767008382	zinc binding site [ion binding]; other site
863767008383	Na+ binding site [ion binding]; other site
863767008384	putative lipid kinase; Reviewed; Region: PRK13055
863767008385	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
863767008386	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712
863767008387	substrate binding site [chemical binding]; other site
863767008388	amidase catalytic site [active]
863767008389	Zn binding residues [ion binding]; other site
863767008390	SH3-like domain; Region: SH3_8; pfam13457
863767008391	SH3-like domain; Region: SH3_8; pfam13457
863767008392	SH3-like domain; Region: SH3_8; pfam13457
863767008393	SH3-like domain; Region: SH3_8; pfam13457
863767008394	CTP synthetase; Validated; Region: pyrG; PRK05380
863767008395	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
863767008396	Catalytic site [active]
863767008397	active site
863767008398	UTP binding site [chemical binding]; other site
863767008399	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
863767008400	active site
863767008401	putative oxyanion hole; other site
863767008402	catalytic triad [active]
863767008403	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
863767008404	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
863767008405	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
863767008406	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
863767008407	active site
863767008408	HIGH motif; other site
863767008409	KMSK motif region; other site
863767008410	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
863767008411	tRNA binding surface [nucleotide binding]; other site
863767008412	anticodon binding site; other site
863767008413	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
863767008414	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
863767008415	Peptidase family M50; Region: Peptidase_M50; pfam02163
863767008416	active site
863767008417	putative substrate binding region [chemical binding]; other site
863767008418	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
863767008419	active site 1 [active]
863767008420	dimer interface [polypeptide binding]; other site
863767008421	hexamer interface [polypeptide binding]; other site
863767008422	active site 2 [active]
863767008423	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
863767008424	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
863767008425	Zn2+ binding site [ion binding]; other site
863767008426	Mg2+ binding site [ion binding]; other site
863767008427	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
863767008428	conserved hypothetical protein TIGR01655; Region: yxeA_fam
863767008429	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
863767008430	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
863767008431	peptide binding site [polypeptide binding]; other site
863767008432	Predicted integral membrane protein [Function unknown]; Region: COG5658
863767008433	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
863767008434	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
863767008435	catalytic triad [active]
863767008436	metal binding site [ion binding]; metal-binding site
863767008437	conserved cis-peptide bond; other site
863767008438	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
863767008439	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
863767008440	folate binding site [chemical binding]; other site
863767008441	NADP+ binding site [chemical binding]; other site
863767008442	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
863767008443	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
863767008444	putative NAD(P) binding site [chemical binding]; other site
863767008445	dimer interface [polypeptide binding]; other site
863767008446	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
863767008447	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
863767008448	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
863767008449	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767008450	active site
863767008451	motif I; other site
863767008452	motif II; other site
863767008453	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
863767008454	Uncharacterized conserved protein [Function unknown]; Region: COG1359
863767008455	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
863767008456	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
863767008457	Walker A/P-loop; other site
863767008458	ATP binding site [chemical binding]; other site
863767008459	Q-loop/lid; other site
863767008460	ABC transporter signature motif; other site
863767008461	Walker B; other site
863767008462	D-loop; other site
863767008463	H-loop/switch region; other site
863767008464	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
863767008465	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
863767008466	FtsX-like permease family; Region: FtsX; pfam02687
863767008467	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
863767008468	dimerization interface [polypeptide binding]; other site
863767008469	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
863767008470	dimer interface [polypeptide binding]; other site
863767008471	phosphorylation site [posttranslational modification]
863767008472	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767008473	ATP binding site [chemical binding]; other site
863767008474	Mg2+ binding site [ion binding]; other site
863767008475	G-X-G motif; other site
863767008476	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
863767008477	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767008478	active site
863767008479	phosphorylation site [posttranslational modification]
863767008480	intermolecular recognition site; other site
863767008481	dimerization interface [polypeptide binding]; other site
863767008482	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
863767008483	DNA binding site [nucleotide binding]
863767008484	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
863767008485	Uncharacterized conserved protein [Function unknown]; Region: COG2427
863767008486	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
863767008487	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
863767008488	catalytic loop [active]
863767008489	iron binding site [ion binding]; other site
863767008490	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
863767008491	4Fe-4S binding domain; Region: Fer4; pfam00037
863767008492	4Fe-4S binding domain; Region: Fer4; pfam00037
863767008493	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
863767008494	[4Fe-4S] binding site [ion binding]; other site
863767008495	molybdopterin cofactor binding site; other site
863767008496	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
863767008497	molybdopterin cofactor binding site; other site
863767008498	Uncharacterized conserved protein [Function unknown]; Region: COG1912
863767008499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767008500	Major Facilitator Superfamily; Region: MFS_1; pfam07690
863767008501	putative substrate translocation pore; other site
863767008502	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
863767008503	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
863767008504	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
863767008505	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
863767008506	Walker A motif; other site
863767008507	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
863767008508	SH3-like domain; Region: SH3_8; pfam13457
863767008509	SH3-like domain; Region: SH3_8; pfam13457
863767008510	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
863767008511	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
863767008512	active site
863767008513	catalytic tetrad [active]
863767008514	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
863767008515	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
863767008516	DNA binding residues [nucleotide binding]
863767008517	putative dimer interface [polypeptide binding]; other site
863767008518	CRISPR/Cas system-associated protein Csn2; Region: Csn2_like; cl09913
863767008519	CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866
863767008520	tetramer interface [polypeptide binding]; other site
863767008521	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
863767008522	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
863767008523	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
863767008524	CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643
863767008525	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
863767008526	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
863767008527	23S rRNA interface [nucleotide binding]; other site
863767008528	L3 interface [polypeptide binding]; other site
863767008529	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
863767008530	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
863767008531	dimerization interface 3.5A [polypeptide binding]; other site
863767008532	active site
863767008533	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
863767008534	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
863767008535	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
863767008536	Walker A/P-loop; other site
863767008537	ATP binding site [chemical binding]; other site
863767008538	Q-loop/lid; other site
863767008539	ABC transporter signature motif; other site
863767008540	Walker B; other site
863767008541	D-loop; other site
863767008542	H-loop/switch region; other site
863767008543	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
863767008544	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
863767008545	Walker A/P-loop; other site
863767008546	ATP binding site [chemical binding]; other site
863767008547	Q-loop/lid; other site
863767008548	ABC transporter signature motif; other site
863767008549	Walker B; other site
863767008550	D-loop; other site
863767008551	H-loop/switch region; other site
863767008552	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
863767008553	MgtC family; Region: MgtC; pfam02308
863767008554	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
863767008555	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
863767008556	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
863767008557	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
863767008558	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
863767008559	alphaNTD - beta interaction site [polypeptide binding]; other site
863767008560	alphaNTD homodimer interface [polypeptide binding]; other site
863767008561	alphaNTD - beta' interaction site [polypeptide binding]; other site
863767008562	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
863767008563	30S ribosomal protein S11; Validated; Region: PRK05309
863767008564	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
863767008565	30S ribosomal protein S13; Region: bact_S13; TIGR03631
863767008566	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
863767008567	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
863767008568	rRNA binding site [nucleotide binding]; other site
863767008569	predicted 30S ribosome binding site; other site
863767008570	adenylate kinase; Reviewed; Region: adk; PRK00279
863767008571	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
863767008572	AMP-binding site [chemical binding]; other site
863767008573	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
863767008574	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
863767008575	SecY translocase; Region: SecY; pfam00344
863767008576	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
863767008577	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
863767008578	23S rRNA binding site [nucleotide binding]; other site
863767008579	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
863767008580	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
863767008581	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
863767008582	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
863767008583	5S rRNA interface [nucleotide binding]; other site
863767008584	L27 interface [polypeptide binding]; other site
863767008585	23S rRNA interface [nucleotide binding]; other site
863767008586	L5 interface [polypeptide binding]; other site
863767008587	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
863767008588	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
863767008589	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
863767008590	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
863767008591	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
863767008592	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
863767008593	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
863767008594	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
863767008595	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
863767008596	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
863767008597	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
863767008598	RNA binding site [nucleotide binding]; other site
863767008599	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
863767008600	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
863767008601	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
863767008602	23S rRNA interface [nucleotide binding]; other site
863767008603	putative translocon interaction site; other site
863767008604	signal recognition particle (SRP54) interaction site; other site
863767008605	L23 interface [polypeptide binding]; other site
863767008606	trigger factor interaction site; other site
863767008607	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
863767008608	23S rRNA interface [nucleotide binding]; other site
863767008609	5S rRNA interface [nucleotide binding]; other site
863767008610	putative antibiotic binding site [chemical binding]; other site
863767008611	L25 interface [polypeptide binding]; other site
863767008612	L27 interface [polypeptide binding]; other site
863767008613	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
863767008614	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
863767008615	G-X-X-G motif; other site
863767008616	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
863767008617	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
863767008618	putative translocon binding site; other site
863767008619	protein-rRNA interface [nucleotide binding]; other site
863767008620	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
863767008621	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
863767008622	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
863767008623	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
863767008624	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
863767008625	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
863767008626	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
863767008627	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
863767008628	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
863767008629	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387
863767008630	UbiA prenyltransferase family; Region: UbiA; pfam01040
863767008631	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
863767008632	ApbE family; Region: ApbE; pfam02424
863767008633	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
863767008634	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
863767008635	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
863767008636	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
863767008637	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
863767008638	Predicted membrane protein [Function unknown]; Region: COG2259
863767008639	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
863767008640	trimer interface [polypeptide binding]; other site
863767008641	Predicted membrane protein [Function unknown]; Region: COG4769
863767008642	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
863767008643	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
863767008644	substrate binding pocket [chemical binding]; other site
863767008645	chain length determination region; other site
863767008646	substrate-Mg2+ binding site; other site
863767008647	catalytic residues [active]
863767008648	aspartate-rich region 1; other site
863767008649	active site lid residues [active]
863767008650	aspartate-rich region 2; other site
863767008651	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
863767008652	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
863767008653	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
863767008654	active site
863767008655	metal binding site [ion binding]; metal-binding site
863767008656	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
863767008657	hypothetical protein; Provisional; Region: PRK02947
863767008658	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
863767008659	putative active site [active]
863767008660	Protein of unknown function (DUF1341); Region: DUF1341; cl06211
863767008661	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
863767008662	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
863767008663	active site
863767008664	substrate binding pocket [chemical binding]; other site
863767008665	homodimer interaction site [polypeptide binding]; other site
863767008666	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
863767008667	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
863767008668	active site
863767008669	P-loop; other site
863767008670	phosphorylation site [posttranslational modification]
863767008671	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767008672	active site
863767008673	phosphorylation site [posttranslational modification]
863767008674	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
863767008675	Mga helix-turn-helix domain; Region: Mga; pfam05043
863767008676	PRD domain; Region: PRD; pfam00874
863767008677	PRD domain; Region: PRD; pfam00874
863767008678	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
863767008679	active site
863767008680	P-loop; other site
863767008681	phosphorylation site [posttranslational modification]
863767008682	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767008683	active site
863767008684	phosphorylation site [posttranslational modification]
863767008685	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
863767008686	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767008687	Walker A/P-loop; other site
863767008688	ATP binding site [chemical binding]; other site
863767008689	Q-loop/lid; other site
863767008690	ABC transporter signature motif; other site
863767008691	Walker B; other site
863767008692	D-loop; other site
863767008693	H-loop/switch region; other site
863767008694	elongation factor Tu; Reviewed; Region: PRK00049
863767008695	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
863767008696	G1 box; other site
863767008697	GEF interaction site [polypeptide binding]; other site
863767008698	GTP/Mg2+ binding site [chemical binding]; other site
863767008699	Switch I region; other site
863767008700	G2 box; other site
863767008701	G3 box; other site
863767008702	Switch II region; other site
863767008703	G4 box; other site
863767008704	G5 box; other site
863767008705	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
863767008706	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
863767008707	Antibiotic Binding Site [chemical binding]; other site
863767008708	elongation factor G; Reviewed; Region: PRK00007
863767008709	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
863767008710	G1 box; other site
863767008711	putative GEF interaction site [polypeptide binding]; other site
863767008712	GTP/Mg2+ binding site [chemical binding]; other site
863767008713	Switch I region; other site
863767008714	G2 box; other site
863767008715	G3 box; other site
863767008716	Switch II region; other site
863767008717	G4 box; other site
863767008718	G5 box; other site
863767008719	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
863767008720	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
863767008721	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
863767008722	30S ribosomal protein S7; Validated; Region: PRK05302
863767008723	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
863767008724	S17 interaction site [polypeptide binding]; other site
863767008725	S8 interaction site; other site
863767008726	16S rRNA interaction site [nucleotide binding]; other site
863767008727	streptomycin interaction site [chemical binding]; other site
863767008728	23S rRNA interaction site [nucleotide binding]; other site
863767008729	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
863767008730	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
863767008731	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
863767008732	Zn2+ binding site [ion binding]; other site
863767008733	Mg2+ binding site [ion binding]; other site
863767008734	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
863767008735	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767008736	Coenzyme A binding pocket [chemical binding]; other site
863767008737	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
863767008738	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767008739	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767008740	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
863767008741	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
863767008742	substrate binding site [chemical binding]; other site
863767008743	hexamer interface [polypeptide binding]; other site
863767008744	metal binding site [ion binding]; metal-binding site
863767008745	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
863767008746	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
863767008747	TPP-binding site [chemical binding]; other site
863767008748	dimer interface [polypeptide binding]; other site
863767008749	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
863767008750	PYR/PP interface [polypeptide binding]; other site
863767008751	dimer interface [polypeptide binding]; other site
863767008752	TPP binding site [chemical binding]; other site
863767008753	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
863767008754	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
863767008755	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
863767008756	substrate binding site [chemical binding]; other site
863767008757	hexamer interface [polypeptide binding]; other site
863767008758	metal binding site [ion binding]; metal-binding site
863767008759	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
863767008760	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
863767008761	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
863767008762	putative NAD(P) binding site [chemical binding]; other site
863767008763	catalytic Zn binding site [ion binding]; other site
863767008764	structural Zn binding site [ion binding]; other site
863767008765	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
863767008766	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
863767008767	putative NAD(P) binding site [chemical binding]; other site
863767008768	catalytic Zn binding site [ion binding]; other site
863767008769	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
863767008770	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
863767008771	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
863767008772	active site
863767008773	P-loop; other site
863767008774	phosphorylation site [posttranslational modification]
863767008775	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767008776	active site
863767008777	phosphorylation site [posttranslational modification]
863767008778	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
863767008779	PRD domain; Region: PRD; pfam00874
863767008780	PRD domain; Region: PRD; pfam00874
863767008781	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
863767008782	active site
863767008783	P-loop; other site
863767008784	phosphorylation site [posttranslational modification]
863767008785	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762
863767008786	active site
863767008787	phosphorylation site [posttranslational modification]
863767008788	Predicted membrane protein [Function unknown]; Region: COG4905
863767008789	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
863767008790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
863767008791	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
863767008792	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
863767008793	active site
863767008794	Helix-turn-helix domain; Region: HTH_18; pfam12833
863767008795	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
863767008796	Ligand Binding Site [chemical binding]; other site
863767008797	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
863767008798	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
863767008799	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
863767008800	active site
863767008801	DNA binding site [nucleotide binding]
863767008802	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
863767008803	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
863767008804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
863767008805	active site
863767008806	phosphorylation site [posttranslational modification]
863767008807	intermolecular recognition site; other site
863767008808	dimerization interface [polypeptide binding]; other site
863767008809	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
863767008810	DNA binding site [nucleotide binding]
863767008811	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
863767008812	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
863767008813	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
863767008814	Ligand Binding Site [chemical binding]; other site
863767008815	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
863767008816	GAF domain; Region: GAF_3; pfam13492
863767008817	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
863767008818	dimer interface [polypeptide binding]; other site
863767008819	phosphorylation site [posttranslational modification]
863767008820	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
863767008821	ATP binding site [chemical binding]; other site
863767008822	Mg2+ binding site [ion binding]; other site
863767008823	G-X-G motif; other site
863767008824	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
863767008825	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
863767008826	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
863767008827	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
863767008828	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
863767008829	active site
863767008830	P-loop; other site
863767008831	phosphorylation site [posttranslational modification]
863767008832	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
863767008833	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
863767008834	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
863767008835	methionine cluster; other site
863767008836	active site
863767008837	phosphorylation site [posttranslational modification]
863767008838	metal binding site [ion binding]; metal-binding site
863767008839	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
863767008840	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
863767008841	magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524
863767008842	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
863767008843	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
863767008844	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
863767008845	Soluble P-type ATPase [General function prediction only]; Region: COG4087
863767008846	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
863767008847	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
863767008848	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
863767008849	autolysin; Reviewed; Region: PRK06347
863767008850	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
863767008851	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
863767008852	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
863767008853	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
863767008854	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
863767008855	Protein of unknown function (DUF970); Region: DUF970; pfam06153
863767008856	thymidylate kinase; Validated; Region: tmk; PRK00698
863767008857	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
863767008858	TMP-binding site; other site
863767008859	ATP-binding site [chemical binding]; other site
863767008860	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
863767008861	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
863767008862	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
863767008863	catalytic residue [active]
863767008864	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
863767008865	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
863767008866	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
863767008867	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
863767008868	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
863767008869	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
863767008870	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
863767008871	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
863767008872	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
863767008873	putative active site [active]
863767008874	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
863767008875	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767008876	active site
863767008877	motif I; other site
863767008878	motif II; other site
863767008879	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
863767008880	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767008881	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767008882	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767008883	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767008884	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767008885	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767008886	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767008887	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
863767008888	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
863767008889	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
863767008890	active site
863767008891	catalytic tetrad [active]
863767008892	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
863767008893	recombination protein RecR; Reviewed; Region: recR; PRK00076
863767008894	RecR protein; Region: RecR; pfam02132
863767008895	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
863767008896	putative active site [active]
863767008897	putative metal-binding site [ion binding]; other site
863767008898	tetramer interface [polypeptide binding]; other site
863767008899	hypothetical protein; Validated; Region: PRK00153
863767008900	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
863767008901	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767008902	Walker A motif; other site
863767008903	ATP binding site [chemical binding]; other site
863767008904	Walker B motif; other site
863767008905	arginine finger; other site
863767008906	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
863767008907	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
863767008908	Protein of unknown function (DUF3188); Region: DUF3188; pfam11384
863767008909	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
863767008910	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
863767008911	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
863767008912	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
863767008913	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
863767008914	N- and C-terminal domain interface [polypeptide binding]; other site
863767008915	active site
863767008916	catalytic site [active]
863767008917	metal binding site [ion binding]; metal-binding site
863767008918	carbohydrate binding site [chemical binding]; other site
863767008919	ATP binding site [chemical binding]; other site
863767008920	SH3-like domain; Region: SH3_8; pfam13457
863767008921	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
863767008922	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
863767008923	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
863767008924	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
863767008925	Walker A/P-loop; other site
863767008926	ATP binding site [chemical binding]; other site
863767008927	Q-loop/lid; other site
863767008928	ABC transporter signature motif; other site
863767008929	Walker B; other site
863767008930	D-loop; other site
863767008931	H-loop/switch region; other site
863767008932	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
863767008933	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
863767008934	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767008935	Walker A/P-loop; other site
863767008936	ATP binding site [chemical binding]; other site
863767008937	Q-loop/lid; other site
863767008938	ABC transporter signature motif; other site
863767008939	Walker B; other site
863767008940	D-loop; other site
863767008941	H-loop/switch region; other site
863767008942	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
863767008943	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
863767008944	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
863767008945	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
863767008946	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
863767008947	nucleoside/Zn binding site; other site
863767008948	dimer interface [polypeptide binding]; other site
863767008949	catalytic motif [active]
863767008950	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
863767008951	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
863767008952	active site
863767008953	acyl-activating enzyme (AAE) consensus motif; other site
863767008954	putative CoA binding site [chemical binding]; other site
863767008955	AMP binding site [chemical binding]; other site
863767008956	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
863767008957	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
863767008958	active site
863767008959	trimer interface [polypeptide binding]; other site
863767008960	allosteric site; other site
863767008961	active site lid [active]
863767008962	hexamer (dimer of trimers) interface [polypeptide binding]; other site
863767008963	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
863767008964	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
863767008965	DNA binding residues [nucleotide binding]
863767008966	drug binding residues [chemical binding]; other site
863767008967	dimer interface [polypeptide binding]; other site
863767008968	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
863767008969	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
863767008970	Coenzyme A binding pocket [chemical binding]; other site
863767008971	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
863767008972	dimer interface [polypeptide binding]; other site
863767008973	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
863767008974	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
863767008975	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
863767008976	MarR family; Region: MarR; pfam01047
863767008977	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
863767008978	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
863767008979	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
863767008980	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
863767008981	DNA binding residues [nucleotide binding]
863767008982	putative dimer interface [polypeptide binding]; other site
863767008983	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
863767008984	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
863767008985	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767008986	active site
863767008987	motif I; other site
863767008988	motif II; other site
863767008989	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
863767008990	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
863767008991	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
863767008992	putative active site [active]
863767008993	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
863767008994	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767008995	active site
863767008996	phosphorylation site [posttranslational modification]
863767008997	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
863767008998	active site
863767008999	P-loop; other site
863767009000	phosphorylation site [posttranslational modification]
863767009001	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
863767009002	alpha-mannosidase; Provisional; Region: PRK09819
863767009003	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
863767009004	active site
863767009005	metal binding site [ion binding]; metal-binding site
863767009006	catalytic site [active]
863767009007	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
863767009008	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
863767009009	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
863767009010	active site
863767009011	homodimer interface [polypeptide binding]; other site
863767009012	catalytic site [active]
863767009013	glycerate kinase; Region: TIGR00045
863767009014	Transcriptional regulators [Transcription]; Region: PurR; COG1609
863767009015	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
863767009016	DNA binding site [nucleotide binding]
863767009017	domain linker motif; other site
863767009018	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
863767009019	putative dimerization interface [polypeptide binding]; other site
863767009020	putative ligand binding site [chemical binding]; other site
863767009021	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
863767009022	Domain of unknown function DUF21; Region: DUF21; pfam01595
863767009023	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
863767009024	Transporter associated domain; Region: CorC_HlyC; pfam03471
863767009025	NAD-dependent deacetylase; Provisional; Region: PRK00481
863767009026	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
863767009027	NAD+ binding site [chemical binding]; other site
863767009028	substrate binding site [chemical binding]; other site
863767009029	putative Zn binding site [ion binding]; other site
863767009030	Pathogenicity locus; Region: Cdd1; pfam11731
863767009031	drug efflux system protein MdtG; Provisional; Region: PRK09874
863767009032	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767009033	putative substrate translocation pore; other site
863767009034	Src Homology 3 domain superfamily; Region: SH3; cl17036
863767009035	Variant SH3 domain; Region: SH3_2; pfam07653
863767009036	peptide ligand binding site [polypeptide binding]; other site
863767009037	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
863767009038	active site
863767009039	intersubunit interactions; other site
863767009040	catalytic residue [active]
863767009041	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
863767009042	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
863767009043	ligand binding site [chemical binding]; other site
863767009044	flexible hinge region; other site
863767009045	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
863767009046	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
863767009047	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
863767009048	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767009049	Walker A/P-loop; other site
863767009050	ATP binding site [chemical binding]; other site
863767009051	Q-loop/lid; other site
863767009052	ABC transporter signature motif; other site
863767009053	Walker B; other site
863767009054	D-loop; other site
863767009055	H-loop/switch region; other site
863767009056	TfoX C-terminal domain; Region: TfoX_C; pfam04994
863767009057	seryl-tRNA synthetase; Provisional; Region: PRK05431
863767009058	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
863767009059	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
863767009060	dimer interface [polypeptide binding]; other site
863767009061	active site
863767009062	motif 1; other site
863767009063	motif 2; other site
863767009064	motif 3; other site
863767009065	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
863767009066	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
863767009067	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
863767009068	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
863767009069	glutamine binding [chemical binding]; other site
863767009070	catalytic triad [active]
863767009071	aminodeoxychorismate synthase; Provisional; Region: PRK07508
863767009072	chorismate binding enzyme; Region: Chorismate_bind; cl10555
863767009073	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
863767009074	substrate-cofactor binding pocket; other site
863767009075	homodimer interface [polypeptide binding]; other site
863767009076	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
863767009077	pyridoxal 5'-phosphate binding site [chemical binding]; other site
863767009078	catalytic residue [active]
863767009079	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
863767009080	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
863767009081	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767009082	Walker A/P-loop; other site
863767009083	ATP binding site [chemical binding]; other site
863767009084	Q-loop/lid; other site
863767009085	ABC transporter signature motif; other site
863767009086	Walker B; other site
863767009087	D-loop; other site
863767009088	H-loop/switch region; other site
863767009089	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
863767009090	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
863767009091	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
863767009092	Walker A/P-loop; other site
863767009093	ATP binding site [chemical binding]; other site
863767009094	Q-loop/lid; other site
863767009095	ABC transporter signature motif; other site
863767009096	Walker B; other site
863767009097	D-loop; other site
863767009098	H-loop/switch region; other site
863767009099	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
863767009100	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
863767009101	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
863767009102	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
863767009103	Predicted acyl esterases [General function prediction only]; Region: COG2936
863767009104	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
863767009105	DNA topoisomerase III; Provisional; Region: PRK07726
863767009106	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
863767009107	active site
863767009108	putative interdomain interaction site [polypeptide binding]; other site
863767009109	putative metal-binding site [ion binding]; other site
863767009110	putative nucleotide binding site [chemical binding]; other site
863767009111	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
863767009112	domain I; other site
863767009113	DNA binding groove [nucleotide binding]
863767009114	phosphate binding site [ion binding]; other site
863767009115	domain II; other site
863767009116	domain III; other site
863767009117	nucleotide binding site [chemical binding]; other site
863767009118	catalytic site [active]
863767009119	domain IV; other site
863767009120	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
863767009121	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
863767009122	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
863767009123	ATP binding site [chemical binding]; other site
863767009124	putative Mg++ binding site [ion binding]; other site
863767009125	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
863767009126	nucleotide binding region [chemical binding]; other site
863767009127	ATP-binding site [chemical binding]; other site
863767009128	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
863767009129	HRDC domain; Region: HRDC; pfam00570
863767009130	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
863767009131	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
863767009132	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
863767009133	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
863767009134	active site
863767009135	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
863767009136	putative ADP-ribose binding site [chemical binding]; other site
863767009137	putative active site [active]
863767009138	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
863767009139	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
863767009140	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
863767009141	ABC transporter; Region: ABC_tran_2; pfam12848
863767009142	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
863767009143	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
863767009144	beta-galactosidase; Region: BGL; TIGR03356
863767009145	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
863767009146	active site
863767009147	P-loop; other site
863767009148	phosphorylation site [posttranslational modification]
863767009149	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
863767009150	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
863767009151	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
863767009152	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
863767009153	nucleotide binding site [chemical binding]; other site
863767009154	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
863767009155	methionine cluster; other site
863767009156	active site
863767009157	phosphorylation site [posttranslational modification]
863767009158	metal binding site [ion binding]; metal-binding site
863767009159	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
863767009160	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
863767009161	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
863767009162	putative active site [active]
863767009163	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
863767009164	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
863767009165	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
863767009166	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
863767009167	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
863767009168	Walker A/P-loop; other site
863767009169	ATP binding site [chemical binding]; other site
863767009170	Q-loop/lid; other site
863767009171	ABC transporter signature motif; other site
863767009172	Walker B; other site
863767009173	D-loop; other site
863767009174	H-loop/switch region; other site
863767009175	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
863767009176	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
863767009177	ATP-grasp domain; Region: ATP-grasp_4; cl17255
863767009178	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
863767009179	beta-galactosidase; Region: BGL; TIGR03356
863767009180	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
863767009181	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
863767009182	active site turn [active]
863767009183	phosphorylation site [posttranslational modification]
863767009184	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
863767009185	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
863767009186	HPr interaction site; other site
863767009187	glycerol kinase (GK) interaction site [polypeptide binding]; other site
863767009188	active site
863767009189	phosphorylation site [posttranslational modification]
863767009190	transcriptional antiterminator BglG; Provisional; Region: PRK09772
863767009191	CAT RNA binding domain; Region: CAT_RBD; smart01061
863767009192	PRD domain; Region: PRD; pfam00874
863767009193	PRD domain; Region: PRD; pfam00874
863767009194	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
863767009195	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
863767009196	Walker A/P-loop; other site
863767009197	ATP binding site [chemical binding]; other site
863767009198	Q-loop/lid; other site
863767009199	ABC transporter signature motif; other site
863767009200	Walker B; other site
863767009201	D-loop; other site
863767009202	H-loop/switch region; other site
863767009203	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
863767009204	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
863767009205	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891
863767009206	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
863767009207	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767009208	putative substrate translocation pore; other site
863767009209	GTP-binding protein YchF; Reviewed; Region: PRK09601
863767009210	YchF GTPase; Region: YchF; cd01900
863767009211	G1 box; other site
863767009212	GTP/Mg2+ binding site [chemical binding]; other site
863767009213	Switch I region; other site
863767009214	G2 box; other site
863767009215	Switch II region; other site
863767009216	G3 box; other site
863767009217	G4 box; other site
863767009218	G5 box; other site
863767009219	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
863767009220	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
863767009221	methionine cluster; other site
863767009222	active site
863767009223	phosphorylation site [posttranslational modification]
863767009224	metal binding site [ion binding]; metal-binding site
863767009225	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
863767009226	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
863767009227	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
863767009228	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
863767009229	active site
863767009230	P-loop; other site
863767009231	phosphorylation site [posttranslational modification]
863767009232	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
863767009233	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
863767009234	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
863767009235	HTH domain; Region: HTH_11; pfam08279
863767009236	Mga helix-turn-helix domain; Region: Mga; pfam05043
863767009237	PRD domain; Region: PRD; pfam00874
863767009238	PRD domain; Region: PRD; pfam00874
863767009239	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
863767009240	active site
863767009241	P-loop; other site
863767009242	phosphorylation site [posttranslational modification]
863767009243	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767009244	active site
863767009245	phosphorylation site [posttranslational modification]
863767009246	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
863767009247	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
863767009248	tetramer interface [polypeptide binding]; other site
863767009249	heme binding pocket [chemical binding]; other site
863767009250	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481
863767009251	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
863767009252	ParB-like nuclease domain; Region: ParB; smart00470
863767009253	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
863767009254	salt bridge; other site
863767009255	non-specific DNA binding site [nucleotide binding]; other site
863767009256	sequence-specific DNA binding site [nucleotide binding]; other site
863767009257	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
863767009258	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
863767009259	P-loop; other site
863767009260	Magnesium ion binding site [ion binding]; other site
863767009261	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
863767009262	Magnesium ion binding site [ion binding]; other site
863767009263	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
863767009264	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767009265	non-specific DNA binding site [nucleotide binding]; other site
863767009266	salt bridge; other site
863767009267	sequence-specific DNA binding site [nucleotide binding]; other site
863767009268	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
863767009269	ParB-like nuclease domain; Region: ParBc; pfam02195
863767009270	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
863767009271	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
863767009272	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
863767009273	putative active site [active]
863767009274	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
863767009275	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
863767009276	nucleotide binding site [chemical binding]; other site
863767009277	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
863767009278	active site
863767009279	phosphorylation site [posttranslational modification]
863767009280	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
863767009281	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767009282	motif II; other site
863767009283	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
863767009284	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
863767009285	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
863767009286	active site
863767009287	P-loop; other site
863767009288	phosphorylation site [posttranslational modification]
863767009289	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
863767009290	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
863767009291	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
863767009292	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
863767009293	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
863767009294	putative active site cavity [active]
863767009295	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
863767009296	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
863767009297	S-adenosylmethionine binding site [chemical binding]; other site
863767009298	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
863767009299	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
863767009300	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
863767009301	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
863767009302	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
863767009303	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
863767009304	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
863767009305	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
863767009306	trmE is a tRNA modification GTPase; Region: trmE; cd04164
863767009307	G1 box; other site
863767009308	GTP/Mg2+ binding site [chemical binding]; other site
863767009309	Switch I region; other site
863767009310	G2 box; other site
863767009311	Switch II region; other site
863767009312	G3 box; other site
863767009313	G4 box; other site
863767009314	G5 box; other site
863767009315	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
863767009316	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
863767009317	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
863767009318	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
863767009319	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
863767009320	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
863767009321	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
863767009322	NADP binding site [chemical binding]; other site
863767009323	homodimer interface [polypeptide binding]; other site
863767009324	active site
863767009325	substrate binding site [chemical binding]; other site
863767009326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767009327	D-galactonate transporter; Region: 2A0114; TIGR00893
863767009328	putative substrate translocation pore; other site
863767009329	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
863767009330	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
863767009331	metal binding site [ion binding]; metal-binding site
863767009332	dimer interface [polypeptide binding]; other site
863767009333	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
863767009334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
863767009335	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
863767009336	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
863767009337	metal binding site [ion binding]; metal-binding site
863767009338	dimer interface [polypeptide binding]; other site
863767009339	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
863767009340	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
863767009341	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
863767009342	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
863767009343	Leucine-rich repeats; other site
863767009344	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767009345	Substrate binding site [chemical binding]; other site
863767009346	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
863767009347	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767009348	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767009349	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767009350	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767009351	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
863767009352	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
863767009353	Uncharacterized conserved protein [Function unknown]; Region: COG4198
863767009354	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
863767009355	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
863767009356	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
863767009357	putative ligand binding site [chemical binding]; other site
863767009358	putative NAD binding site [chemical binding]; other site
863767009359	putative catalytic site [active]
863767009360	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
863767009361	L-serine binding site [chemical binding]; other site
863767009362	ACT domain interface; other site
863767009363	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
863767009364	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
863767009365	catalytic residue [active]
863767009366	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767009367	Major Facilitator Superfamily; Region: MFS_1; pfam07690
863767009368	putative substrate translocation pore; other site
863767009369	Transcriptional regulators [Transcription]; Region: MarR; COG1846
863767009370	MarR family; Region: MarR_2; pfam12802
863767009371	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
863767009372	dimer interface [polypeptide binding]; other site
863767009373	FMN binding site [chemical binding]; other site
863767009374	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
863767009375	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
863767009376	catalytic residues [active]
863767009377	beta-phosphoglucomutase; Region: bPGM; TIGR01990
863767009378	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
863767009379	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
863767009380	motif II; other site
863767009381	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
863767009382	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
863767009383	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
863767009384	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
863767009385	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
863767009386	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
863767009387	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
863767009388	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
863767009389	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
863767009390	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
863767009391	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
863767009392	putative NAD(P) binding site [chemical binding]; other site
863767009393	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
863767009394	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767009395	dimer interface [polypeptide binding]; other site
863767009396	conserved gate region; other site
863767009397	putative PBP binding loops; other site
863767009398	ABC-ATPase subunit interface; other site
863767009399	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
863767009400	dimer interface [polypeptide binding]; other site
863767009401	conserved gate region; other site
863767009402	putative PBP binding loops; other site
863767009403	ABC-ATPase subunit interface; other site
863767009404	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
863767009405	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
863767009406	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
863767009407	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
863767009408	active site
863767009409	homodimer interface [polypeptide binding]; other site
863767009410	catalytic site [active]
863767009411	Transcriptional regulators [Transcription]; Region: PurR; COG1609
863767009412	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
863767009413	DNA binding site [nucleotide binding]
863767009414	domain linker motif; other site
863767009415	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
863767009416	putative dimerization interface [polypeptide binding]; other site
863767009417	putative ligand binding site [chemical binding]; other site
863767009418	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
863767009419	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
863767009420	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
863767009421	Coenzyme A binding pocket [chemical binding]; other site
863767009422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767009423	Major Facilitator Superfamily; Region: MFS_1; pfam07690
863767009424	putative substrate translocation pore; other site
863767009425	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767009426	Domain of unknown function (DUF718); Region: DUF718; cl01281
863767009427	rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624
863767009428	intersubunit interface [polypeptide binding]; other site
863767009429	active site
863767009430	Zn2+ binding site [ion binding]; other site
863767009431	L-rhamnose isomerase; Provisional; Region: PRK01076
863767009432	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
863767009433	N- and C-terminal domain interface [polypeptide binding]; other site
863767009434	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
863767009435	active site
863767009436	putative catalytic site [active]
863767009437	metal binding site [ion binding]; metal-binding site
863767009438	ATP binding site [chemical binding]; other site
863767009439	carbohydrate binding site [chemical binding]; other site
863767009440	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
863767009441	putative substrate translocation pore; other site
863767009442	Major Facilitator Superfamily; Region: MFS_1; pfam07690
863767009443	Cupin domain; Region: Cupin_2; pfam07883
863767009444	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
863767009445	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
863767009446	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
863767009447	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
863767009448	G-X-X-G motif; other site
863767009449	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
863767009450	RxxxH motif; other site
863767009451	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
863767009452	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
863767009453	ribonuclease P; Reviewed; Region: rnpA; PRK00499
863767009454	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
863767009455	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
863767009456	Integrase core domain; Region: rve; pfam00665
863767009457	Integrase core domain; Region: rve_3; pfam13683
863767009458	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
863767009459	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767009460	Walker A motif; other site
863767009461	ATP binding site [chemical binding]; other site
863767009462	Walker B motif; other site
863767009463	arginine finger; other site
863767009464	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
863767009465	Integrase core domain; Region: rve; pfam00665
863767009466	Fic family protein [Function unknown]; Region: COG3177
863767009467	Fic/DOC family; Region: Fic; pfam02661
863767009468	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
863767009469	non-specific DNA binding site [nucleotide binding]; other site
863767009470	salt bridge; other site
863767009471	sequence-specific DNA binding site [nucleotide binding]; other site
863767009472	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
863767009473	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
863767009474	Integrase core domain; Region: rve; pfam00665
863767009475	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
863767009476	Integrase core domain; Region: rve; pfam00665
863767009477	Domain of unknown function DUF87; Region: DUF87; pfam01935
863767009478	HerA helicase [Replication, recombination, and repair]; Region: COG0433
863767009479	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
863767009480	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
863767009481	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
863767009482	catalytic residues [active]
863767009483	catalytic nucleophile [active]
863767009484	Presynaptic Site I dimer interface [polypeptide binding]; other site
863767009485	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
863767009486	Synaptic Flat tetramer interface [polypeptide binding]; other site
863767009487	Synaptic Site I dimer interface [polypeptide binding]; other site
863767009488	DNA binding site [nucleotide binding]
863767009489	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
863767009490	DNA-binding interface [nucleotide binding]; DNA binding site
863767009491	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
863767009492	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
863767009493	Soluble P-type ATPase [General function prediction only]; Region: COG4087
863767009494	multicopper oxidase; Provisional; Region: PRK10965
863767009495	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
863767009496	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
863767009497	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
863767009498	multiple promoter invertase; Provisional; Region: mpi; PRK13413
863767009499	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
863767009500	catalytic residues [active]
863767009501	catalytic nucleophile [active]
863767009502	Presynaptic Site I dimer interface [polypeptide binding]; other site
863767009503	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
863767009504	Synaptic Flat tetramer interface [polypeptide binding]; other site
863767009505	Synaptic Site I dimer interface [polypeptide binding]; other site
863767009506	DNA binding site [nucleotide binding]
863767009507	Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
863767009508	DNA-binding interface [nucleotide binding]; DNA binding site
863767009509	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
863767009510	dimerization interface [polypeptide binding]; other site
863767009511	putative DNA binding site [nucleotide binding]; other site
863767009512	putative Zn2+ binding site [ion binding]; other site
863767009513	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
863767009514	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
863767009515	metal-binding site [ion binding]
863767009516	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
863767009517	Soluble P-type ATPase [General function prediction only]; Region: COG4087
863767009518	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
863767009519	Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961
863767009520	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
863767009521	AP2 domain; Region: AP2; pfam00847
863767009522	putative transposase OrfB; Reviewed; Region: PHA02517
863767009523	HTH-like domain; Region: HTH_21; pfam13276
863767009524	Integrase core domain; Region: rve; pfam00665
863767009525	Integrase core domain; Region: rve_3; pfam13683
863767009526	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
863767009527	Transposase; Region: HTH_Tnp_1; cl17663
863767009528	7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416
863767009529	multiple promoter invertase; Provisional; Region: mpi; PRK13413
863767009530	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
863767009531	catalytic residues [active]
863767009532	catalytic nucleophile [active]
863767009533	Presynaptic Site I dimer interface [polypeptide binding]; other site
863767009534	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
863767009535	Synaptic Flat tetramer interface [polypeptide binding]; other site
863767009536	Synaptic Site I dimer interface [polypeptide binding]; other site
863767009537	DNA binding site [nucleotide binding]
863767009538	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767009539	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
863767009540	Walker A motif; other site
863767009541	ATP binding site [chemical binding]; other site
863767009542	Walker B motif; other site
863767009543	arginine finger; other site
863767009544	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
863767009545	Walker A motif; other site
863767009546	ATP binding site [chemical binding]; other site
863767009547	Walker B motif; other site
863767009548	arginine finger; other site
863767009549	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
863767009550	Helix-turn-helix domain; Region: HTH_28; pfam13518
863767009551	putative transposase OrfB; Reviewed; Region: PHA02517
863767009552	HTH-like domain; Region: HTH_21; pfam13276
863767009553	Integrase core domain; Region: rve; pfam00665
863767009554	Integrase core domain; Region: rve_3; pfam13683
863767009555	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
863767009556	P-loop; other site
863767009557	Magnesium ion binding site [ion binding]; other site
863767009558	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
863767009559	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
863767009560	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
863767009561	active site
863767009562	DNA binding site [nucleotide binding]
863767009563	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
863767009564	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
863767009565	P-loop; other site
863767009566	Magnesium ion binding site [ion binding]; other site
863767009567	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
863767009568	Magnesium ion binding site [ion binding]; other site