-- dump date   	20140619_134507
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
653938000001	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
653938000002	ribonuclease P; Reviewed; Region: rnpA; PRK00499
653938000003	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
653938000004	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
653938000005	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
653938000006	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
653938000007	G-X-X-G motif; other site
653938000008	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
653938000009	RxxxH motif; other site
653938000010	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
653938000011	Cupin domain; Region: Cupin_2; pfam07883
653938000012	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
653938000013	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938000014	putative substrate translocation pore; other site
653938000015	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653938000016	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
653938000017	N- and C-terminal domain interface [polypeptide binding]; other site
653938000018	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
653938000019	active site
653938000020	putative catalytic site [active]
653938000021	metal binding site [ion binding]; metal-binding site
653938000022	ATP binding site [chemical binding]; other site
653938000023	carbohydrate binding site [chemical binding]; other site
653938000024	L-rhamnose isomerase; Provisional; Region: PRK01076
653938000025	rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624
653938000026	intersubunit interface [polypeptide binding]; other site
653938000027	active site
653938000028	Zn2+ binding site [ion binding]; other site
653938000029	Domain of unknown function (DUF718); Region: DUF718; cl01281
653938000030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938000031	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653938000032	putative substrate translocation pore; other site
653938000033	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938000034	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
653938000035	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938000036	Coenzyme A binding pocket [chemical binding]; other site
653938000037	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
653938000038	Transcriptional regulators [Transcription]; Region: PurR; COG1609
653938000039	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
653938000040	DNA binding site [nucleotide binding]
653938000041	domain linker motif; other site
653938000042	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
653938000043	putative dimerization interface [polypeptide binding]; other site
653938000044	putative ligand binding site [chemical binding]; other site
653938000045	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
653938000046	sucrose phosphorylase; Provisional; Region: PRK13840
653938000047	active site
653938000048	homodimer interface [polypeptide binding]; other site
653938000049	catalytic site [active]
653938000050	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
653938000051	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
653938000052	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938000053	dimer interface [polypeptide binding]; other site
653938000054	conserved gate region; other site
653938000055	putative PBP binding loops; other site
653938000056	ABC-ATPase subunit interface; other site
653938000057	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
653938000058	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938000059	dimer interface [polypeptide binding]; other site
653938000060	conserved gate region; other site
653938000061	putative PBP binding loops; other site
653938000062	ABC-ATPase subunit interface; other site
653938000063	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
653938000064	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
653938000065	putative NAD(P) binding site [chemical binding]; other site
653938000066	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
653938000067	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
653938000068	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
653938000069	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
653938000070	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
653938000071	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
653938000072	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
653938000073	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
653938000074	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
653938000075	beta-phosphoglucomutase; Region: bPGM; TIGR01990
653938000076	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
653938000077	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938000078	motif II; other site
653938000079	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
653938000080	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
653938000081	catalytic residues [active]
653938000082	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
653938000083	dimer interface [polypeptide binding]; other site
653938000084	FMN binding site [chemical binding]; other site
653938000085	YolD-like protein; Region: YolD; pfam08863
653938000086	Transcriptional regulators [Transcription]; Region: MarR; COG1846
653938000087	MarR family; Region: MarR_2; pfam12802
653938000088	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938000089	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653938000090	putative substrate translocation pore; other site
653938000091	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
653938000092	homodimer interface [polypeptide binding]; other site
653938000093	substrate-cofactor binding pocket; other site
653938000094	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938000095	catalytic residue [active]
653938000096	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
653938000097	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
653938000098	putative ligand binding site [chemical binding]; other site
653938000099	putative NAD binding site [chemical binding]; other site
653938000100	putative catalytic site [active]
653938000101	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
653938000102	L-serine binding site [chemical binding]; other site
653938000103	ACT domain interface; other site
653938000104	Uncharacterized conserved protein [Function unknown]; Region: COG4198
653938000105	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
653938000106	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
653938000107	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
653938000108	Leucine-rich repeats; other site
653938000109	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938000110	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938000111	Substrate binding site [chemical binding]; other site
653938000112	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938000113	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938000114	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938000115	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938000116	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
653938000117	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
653938000118	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
653938000119	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
653938000120	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
653938000121	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
653938000122	metal binding site [ion binding]; metal-binding site
653938000123	dimer interface [polypeptide binding]; other site
653938000124	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
653938000125	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
653938000126	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
653938000127	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
653938000128	metal binding site [ion binding]; metal-binding site
653938000129	dimer interface [polypeptide binding]; other site
653938000130	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938000131	D-galactonate transporter; Region: 2A0114; TIGR00893
653938000132	putative substrate translocation pore; other site
653938000133	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
653938000134	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
653938000135	NADP binding site [chemical binding]; other site
653938000136	homodimer interface [polypeptide binding]; other site
653938000137	active site
653938000138	substrate binding site [chemical binding]; other site
653938000139	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
653938000140	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
653938000141	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
653938000142	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
653938000143	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
653938000144	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
653938000145	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
653938000146	trmE is a tRNA modification GTPase; Region: trmE; cd04164
653938000147	G1 box; other site
653938000148	GTP/Mg2+ binding site [chemical binding]; other site
653938000149	Switch I region; other site
653938000150	G2 box; other site
653938000151	Switch II region; other site
653938000152	G3 box; other site
653938000153	G4 box; other site
653938000154	G5 box; other site
653938000155	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
653938000156	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
653938000157	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
653938000158	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
653938000159	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
653938000160	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
653938000161	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
653938000162	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
653938000163	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
653938000164	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
653938000165	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
653938000166	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938000167	S-adenosylmethionine binding site [chemical binding]; other site
653938000168	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
653938000169	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
653938000170	putative active site cavity [active]
653938000171	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
653938000172	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
653938000173	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
653938000174	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
653938000175	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
653938000176	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
653938000177	active site
653938000178	P-loop; other site
653938000179	phosphorylation site [posttranslational modification]
653938000180	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
653938000181	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938000182	motif II; other site
653938000183	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938000184	active site
653938000185	phosphorylation site [posttranslational modification]
653938000186	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
653938000187	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
653938000188	nucleotide binding site [chemical binding]; other site
653938000189	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
653938000190	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
653938000191	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
653938000192	putative active site [active]
653938000193	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
653938000194	ParB-like nuclease domain; Region: ParBc; pfam02195
653938000195	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938000196	non-specific DNA binding site [nucleotide binding]; other site
653938000197	salt bridge; other site
653938000198	sequence-specific DNA binding site [nucleotide binding]; other site
653938000199	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
653938000200	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
653938000201	P-loop; other site
653938000202	Magnesium ion binding site [ion binding]; other site
653938000203	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
653938000204	Magnesium ion binding site [ion binding]; other site
653938000205	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
653938000206	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
653938000207	ParB-like nuclease domain; Region: ParB; smart00470
653938000208	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481
653938000209	transcriptional antiterminator BglG; Provisional; Region: PRK09772
653938000210	CAT RNA binding domain; Region: CAT_RBD; pfam03123
653938000211	PRD domain; Region: PRD; pfam00874
653938000212	PRD domain; Region: PRD; pfam00874
653938000213	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
653938000214	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
653938000215	active site turn [active]
653938000216	phosphorylation site [posttranslational modification]
653938000217	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
653938000218	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
653938000219	HPr interaction site; other site
653938000220	glycerol kinase (GK) interaction site [polypeptide binding]; other site
653938000221	active site
653938000222	phosphorylation site [posttranslational modification]
653938000223	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
653938000224	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
653938000225	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
653938000226	tetramer interface [polypeptide binding]; other site
653938000227	heme binding pocket [chemical binding]; other site
653938000228	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
653938000229	HTH domain; Region: HTH_11; pfam08279
653938000230	Mga helix-turn-helix domain; Region: Mga; pfam05043
653938000231	PRD domain; Region: PRD; pfam00874
653938000232	PRD domain; Region: PRD; pfam00874
653938000233	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
653938000234	active site
653938000235	P-loop; other site
653938000236	phosphorylation site [posttranslational modification]
653938000237	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938000238	active site
653938000239	phosphorylation site [posttranslational modification]
653938000240	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
653938000241	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
653938000242	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
653938000243	active site
653938000244	P-loop; other site
653938000245	phosphorylation site [posttranslational modification]
653938000246	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
653938000247	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
653938000248	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
653938000249	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
653938000250	methionine cluster; other site
653938000251	active site
653938000252	phosphorylation site [posttranslational modification]
653938000253	metal binding site [ion binding]; metal-binding site
653938000254	GTP-binding protein YchF; Reviewed; Region: PRK09601
653938000255	YchF GTPase; Region: YchF; cd01900
653938000256	G1 box; other site
653938000257	GTP/Mg2+ binding site [chemical binding]; other site
653938000258	Switch I region; other site
653938000259	G2 box; other site
653938000260	Switch II region; other site
653938000261	G3 box; other site
653938000262	G4 box; other site
653938000263	G5 box; other site
653938000264	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
653938000265	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
653938000266	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938000267	putative substrate translocation pore; other site
653938000268	transcriptional antiterminator BglG; Provisional; Region: PRK09772
653938000269	CAT RNA binding domain; Region: CAT_RBD; smart01061
653938000270	PRD domain; Region: PRD; pfam00874
653938000271	PRD domain; Region: PRD; pfam00874
653938000272	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
653938000273	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
653938000274	active site turn [active]
653938000275	phosphorylation site [posttranslational modification]
653938000276	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
653938000277	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
653938000278	HPr interaction site; other site
653938000279	glycerol kinase (GK) interaction site [polypeptide binding]; other site
653938000280	active site
653938000281	phosphorylation site [posttranslational modification]
653938000282	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
653938000283	beta-galactosidase; Region: BGL; TIGR03356
653938000284	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
653938000285	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
653938000286	ATP-grasp domain; Region: ATP-grasp_4; cl17255
653938000287	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
653938000288	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
653938000289	Walker A/P-loop; other site
653938000290	ATP binding site [chemical binding]; other site
653938000291	Q-loop/lid; other site
653938000292	ABC transporter signature motif; other site
653938000293	Walker B; other site
653938000294	D-loop; other site
653938000295	H-loop/switch region; other site
653938000296	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
653938000297	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
653938000298	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
653938000299	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
653938000300	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
653938000301	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
653938000302	putative active site [active]
653938000303	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
653938000304	methionine cluster; other site
653938000305	active site
653938000306	phosphorylation site [posttranslational modification]
653938000307	metal binding site [ion binding]; metal-binding site
653938000308	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
653938000309	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
653938000310	nucleotide binding site [chemical binding]; other site
653938000311	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
653938000312	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
653938000313	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
653938000314	active site
653938000315	P-loop; other site
653938000316	phosphorylation site [posttranslational modification]
653938000317	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
653938000318	beta-galactosidase; Region: BGL; TIGR03356
653938000319	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
653938000320	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653938000321	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653938000322	ABC transporter; Region: ABC_tran_2; pfam12848
653938000323	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653938000324	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
653938000325	putative ADP-ribose binding site [chemical binding]; other site
653938000326	putative active site [active]
653938000327	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
653938000328	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
653938000329	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
653938000330	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
653938000331	active site
653938000332	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
653938000333	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653938000334	ATP binding site [chemical binding]; other site
653938000335	putative Mg++ binding site [ion binding]; other site
653938000336	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653938000337	nucleotide binding region [chemical binding]; other site
653938000338	ATP-binding site [chemical binding]; other site
653938000339	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
653938000340	HRDC domain; Region: HRDC; pfam00570
653938000341	DNA topoisomerase III; Provisional; Region: PRK07726
653938000342	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
653938000343	active site
653938000344	putative interdomain interaction site [polypeptide binding]; other site
653938000345	putative metal-binding site [ion binding]; other site
653938000346	putative nucleotide binding site [chemical binding]; other site
653938000347	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
653938000348	domain I; other site
653938000349	DNA binding groove [nucleotide binding]
653938000350	phosphate binding site [ion binding]; other site
653938000351	domain II; other site
653938000352	domain III; other site
653938000353	nucleotide binding site [chemical binding]; other site
653938000354	catalytic site [active]
653938000355	domain IV; other site
653938000356	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
653938000357	Predicted acyl esterases [General function prediction only]; Region: COG2936
653938000358	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
653938000359	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
653938000360	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
653938000361	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
653938000362	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
653938000363	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653938000364	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938000365	Walker A/P-loop; other site
653938000366	ATP binding site [chemical binding]; other site
653938000367	Q-loop/lid; other site
653938000368	ABC transporter signature motif; other site
653938000369	Walker B; other site
653938000370	D-loop; other site
653938000371	H-loop/switch region; other site
653938000372	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
653938000373	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653938000374	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938000375	Walker A/P-loop; other site
653938000376	ATP binding site [chemical binding]; other site
653938000377	Q-loop/lid; other site
653938000378	ABC transporter signature motif; other site
653938000379	Walker B; other site
653938000380	D-loop; other site
653938000381	H-loop/switch region; other site
653938000382	aminodeoxychorismate synthase; Provisional; Region: PRK07508
653938000383	chorismate binding enzyme; Region: Chorismate_bind; cl10555
653938000384	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
653938000385	substrate-cofactor binding pocket; other site
653938000386	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
653938000387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938000388	catalytic residue [active]
653938000389	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
653938000390	Glutamine amidotransferase class-I; Region: GATase; pfam00117
653938000391	glutamine binding [chemical binding]; other site
653938000392	catalytic triad [active]
653938000393	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
653938000394	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
653938000395	seryl-tRNA synthetase; Provisional; Region: PRK05431
653938000396	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
653938000397	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
653938000398	dimer interface [polypeptide binding]; other site
653938000399	active site
653938000400	motif 1; other site
653938000401	motif 2; other site
653938000402	motif 3; other site
653938000403	TfoX C-terminal domain; Region: TfoX_C; pfam04994
653938000404	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
653938000405	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653938000406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938000407	Walker A/P-loop; other site
653938000408	ATP binding site [chemical binding]; other site
653938000409	Q-loop/lid; other site
653938000410	ABC transporter signature motif; other site
653938000411	Walker B; other site
653938000412	D-loop; other site
653938000413	H-loop/switch region; other site
653938000414	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938000415	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
653938000416	ligand binding site [chemical binding]; other site
653938000417	flexible hinge region; other site
653938000418	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
653938000419	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
653938000420	active site
653938000421	intersubunit interactions; other site
653938000422	catalytic residue [active]
653938000423	Src Homology 3 domain superfamily; Region: SH3; cl17036
653938000424	Variant SH3 domain; Region: SH3_2; pfam07653
653938000425	drug efflux system protein MdtG; Provisional; Region: PRK09874
653938000426	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938000427	putative substrate translocation pore; other site
653938000428	Pathogenicity locus; Region: Cdd1; pfam11731
653938000429	NAD-dependent deacetylase; Provisional; Region: PRK00481
653938000430	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
653938000431	NAD+ binding site [chemical binding]; other site
653938000432	substrate binding site [chemical binding]; other site
653938000433	putative Zn binding site [ion binding]; other site
653938000434	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
653938000435	Domain of unknown function DUF21; Region: DUF21; pfam01595
653938000436	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
653938000437	Transporter associated domain; Region: CorC_HlyC; pfam03471
653938000438	Transcriptional regulators [Transcription]; Region: PurR; COG1609
653938000439	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
653938000440	DNA binding site [nucleotide binding]
653938000441	domain linker motif; other site
653938000442	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
653938000443	putative dimerization interface [polypeptide binding]; other site
653938000444	putative ligand binding site [chemical binding]; other site
653938000445	glycerate kinase; Region: TIGR00045
653938000446	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
653938000447	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
653938000448	active site
653938000449	homodimer interface [polypeptide binding]; other site
653938000450	catalytic site [active]
653938000451	alpha-mannosidase; Provisional; Region: PRK09819
653938000452	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
653938000453	active site
653938000454	metal binding site [ion binding]; metal-binding site
653938000455	catalytic site [active]
653938000456	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
653938000457	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
653938000458	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938000459	active site
653938000460	phosphorylation site [posttranslational modification]
653938000461	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
653938000462	active site
653938000463	P-loop; other site
653938000464	phosphorylation site [posttranslational modification]
653938000465	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
653938000466	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
653938000467	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
653938000468	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
653938000469	putative active site [active]
653938000470	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
653938000471	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938000472	active site
653938000473	motif I; other site
653938000474	motif II; other site
653938000475	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
653938000476	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
653938000477	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
653938000478	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
653938000479	MarR family; Region: MarR; pfam01047
653938000480	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
653938000481	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
653938000482	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
653938000483	dimer interface [polypeptide binding]; other site
653938000484	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
653938000485	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938000486	Coenzyme A binding pocket [chemical binding]; other site
653938000487	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
653938000488	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
653938000489	DNA binding residues [nucleotide binding]
653938000490	drug binding residues [chemical binding]; other site
653938000491	dimer interface [polypeptide binding]; other site
653938000492	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
653938000493	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
653938000494	active site
653938000495	trimer interface [polypeptide binding]; other site
653938000496	allosteric site; other site
653938000497	active site lid [active]
653938000498	hexamer (dimer of trimers) interface [polypeptide binding]; other site
653938000499	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
653938000500	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
653938000501	active site
653938000502	acyl-activating enzyme (AAE) consensus motif; other site
653938000503	putative CoA binding site [chemical binding]; other site
653938000504	AMP binding site [chemical binding]; other site
653938000505	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
653938000506	nucleoside/Zn binding site; other site
653938000507	dimer interface [polypeptide binding]; other site
653938000508	catalytic motif [active]
653938000509	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
653938000510	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
653938000511	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
653938000512	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
653938000513	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
653938000514	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653938000515	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938000516	Walker A/P-loop; other site
653938000517	ATP binding site [chemical binding]; other site
653938000518	Q-loop/lid; other site
653938000519	ABC transporter signature motif; other site
653938000520	Walker B; other site
653938000521	D-loop; other site
653938000522	H-loop/switch region; other site
653938000523	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
653938000524	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653938000525	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
653938000526	Walker A/P-loop; other site
653938000527	ATP binding site [chemical binding]; other site
653938000528	Q-loop/lid; other site
653938000529	ABC transporter signature motif; other site
653938000530	Walker B; other site
653938000531	D-loop; other site
653938000532	H-loop/switch region; other site
653938000533	SH3-like domain; Region: SH3_8; pfam13457
653938000534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
653938000535	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
653938000536	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
653938000537	N- and C-terminal domain interface [polypeptide binding]; other site
653938000538	active site
653938000539	catalytic site [active]
653938000540	metal binding site [ion binding]; metal-binding site
653938000541	carbohydrate binding site [chemical binding]; other site
653938000542	ATP binding site [chemical binding]; other site
653938000543	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
653938000544	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
653938000545	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
653938000546	Protein of unknown function (DUF3188); Region: DUF3188; pfam11384
653938000547	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
653938000548	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
653938000549	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938000550	Walker A motif; other site
653938000551	ATP binding site [chemical binding]; other site
653938000552	Walker B motif; other site
653938000553	arginine finger; other site
653938000554	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
653938000555	hypothetical protein; Validated; Region: PRK00153
653938000556	recombination protein RecR; Reviewed; Region: recR; PRK00076
653938000557	RecR protein; Region: RecR; pfam02132
653938000558	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
653938000559	putative active site [active]
653938000560	putative metal-binding site [ion binding]; other site
653938000561	tetramer interface [polypeptide binding]; other site
653938000562	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
653938000563	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
653938000564	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
653938000565	active site
653938000566	catalytic tetrad [active]
653938000567	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
653938000568	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938000569	active site
653938000570	motif I; other site
653938000571	motif II; other site
653938000572	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
653938000573	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
653938000574	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
653938000575	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
653938000576	putative active site [active]
653938000577	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
653938000578	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
653938000579	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
653938000580	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
653938000581	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
653938000582	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
653938000583	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
653938000584	homodimer interface [polypeptide binding]; other site
653938000585	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938000586	catalytic residue [active]
653938000587	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
653938000588	thymidylate kinase; Validated; Region: tmk; PRK00698
653938000589	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
653938000590	TMP-binding site; other site
653938000591	ATP-binding site [chemical binding]; other site
653938000592	Protein of unknown function (DUF970); Region: DUF970; pfam06153
653938000593	autolysin; Reviewed; Region: PRK06347
653938000594	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
653938000595	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653938000596	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653938000597	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653938000598	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653938000599	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
653938000600	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
653938000601	magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524
653938000602	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
653938000603	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
653938000604	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
653938000605	Soluble P-type ATPase [General function prediction only]; Region: COG4087
653938000606	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
653938000607	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
653938000608	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
653938000609	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
653938000610	methionine cluster; other site
653938000611	active site
653938000612	phosphorylation site [posttranslational modification]
653938000613	metal binding site [ion binding]; metal-binding site
653938000614	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
653938000615	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
653938000616	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
653938000617	active site
653938000618	P-loop; other site
653938000619	phosphorylation site [posttranslational modification]
653938000620	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
653938000621	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
653938000622	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
653938000623	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
653938000624	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
653938000625	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
653938000626	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
653938000627	Ligand Binding Site [chemical binding]; other site
653938000628	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
653938000629	GAF domain; Region: GAF_3; pfam13492
653938000630	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653938000631	dimer interface [polypeptide binding]; other site
653938000632	phosphorylation site [posttranslational modification]
653938000633	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938000634	ATP binding site [chemical binding]; other site
653938000635	Mg2+ binding site [ion binding]; other site
653938000636	G-X-G motif; other site
653938000637	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
653938000638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938000639	active site
653938000640	phosphorylation site [posttranslational modification]
653938000641	intermolecular recognition site; other site
653938000642	dimerization interface [polypeptide binding]; other site
653938000643	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
653938000644	DNA binding site [nucleotide binding]
653938000645	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
653938000646	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
653938000647	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
653938000648	active site
653938000649	DNA binding site [nucleotide binding]
653938000650	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
653938000651	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
653938000652	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
653938000653	Ligand Binding Site [chemical binding]; other site
653938000654	Helix-turn-helix domain; Region: HTH_18; pfam12833
653938000655	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
653938000656	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
653938000657	active site
653938000658	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
653938000659	Predicted membrane protein [Function unknown]; Region: COG4905
653938000660	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
653938000661	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
653938000662	PRD domain; Region: PRD; pfam00874
653938000663	PRD domain; Region: PRD; pfam00874
653938000664	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
653938000665	active site
653938000666	P-loop; other site
653938000667	phosphorylation site [posttranslational modification]
653938000668	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938000669	active site
653938000670	phosphorylation site [posttranslational modification]
653938000671	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938000672	active site
653938000673	phosphorylation site [posttranslational modification]
653938000674	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
653938000675	active site
653938000676	P-loop; other site
653938000677	phosphorylation site [posttranslational modification]
653938000678	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
653938000679	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
653938000680	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
653938000681	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
653938000682	putative NAD(P) binding site [chemical binding]; other site
653938000683	catalytic Zn binding site [ion binding]; other site
653938000684	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
653938000685	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
653938000686	putative NAD(P) binding site [chemical binding]; other site
653938000687	catalytic Zn binding site [ion binding]; other site
653938000688	structural Zn binding site [ion binding]; other site
653938000689	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
653938000690	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
653938000691	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
653938000692	substrate binding site [chemical binding]; other site
653938000693	hexamer interface [polypeptide binding]; other site
653938000694	metal binding site [ion binding]; metal-binding site
653938000695	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
653938000696	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
653938000697	TPP-binding site [chemical binding]; other site
653938000698	dimer interface [polypeptide binding]; other site
653938000699	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
653938000700	PYR/PP interface [polypeptide binding]; other site
653938000701	dimer interface [polypeptide binding]; other site
653938000702	TPP binding site [chemical binding]; other site
653938000703	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
653938000704	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
653938000705	substrate binding site [chemical binding]; other site
653938000706	hexamer interface [polypeptide binding]; other site
653938000707	metal binding site [ion binding]; metal-binding site
653938000708	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938000709	Coenzyme A binding pocket [chemical binding]; other site
653938000710	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
653938000711	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653938000712	Zn2+ binding site [ion binding]; other site
653938000713	Mg2+ binding site [ion binding]; other site
653938000714	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
653938000715	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
653938000716	S17 interaction site [polypeptide binding]; other site
653938000717	S8 interaction site; other site
653938000718	16S rRNA interaction site [nucleotide binding]; other site
653938000719	streptomycin interaction site [chemical binding]; other site
653938000720	23S rRNA interaction site [nucleotide binding]; other site
653938000721	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
653938000722	30S ribosomal protein S7; Validated; Region: PRK05302
653938000723	elongation factor G; Reviewed; Region: PRK00007
653938000724	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
653938000725	G1 box; other site
653938000726	putative GEF interaction site [polypeptide binding]; other site
653938000727	GTP/Mg2+ binding site [chemical binding]; other site
653938000728	Switch I region; other site
653938000729	G2 box; other site
653938000730	G3 box; other site
653938000731	Switch II region; other site
653938000732	G4 box; other site
653938000733	G5 box; other site
653938000734	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
653938000735	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
653938000736	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
653938000737	elongation factor Tu; Reviewed; Region: PRK00049
653938000738	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
653938000739	G1 box; other site
653938000740	GEF interaction site [polypeptide binding]; other site
653938000741	GTP/Mg2+ binding site [chemical binding]; other site
653938000742	Switch I region; other site
653938000743	G2 box; other site
653938000744	G3 box; other site
653938000745	Switch II region; other site
653938000746	G4 box; other site
653938000747	G5 box; other site
653938000748	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
653938000749	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
653938000750	Antibiotic Binding Site [chemical binding]; other site
653938000751	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
653938000752	Mga helix-turn-helix domain; Region: Mga; pfam05043
653938000753	PRD domain; Region: PRD; pfam00874
653938000754	PRD domain; Region: PRD; pfam00874
653938000755	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
653938000756	active site
653938000757	P-loop; other site
653938000758	phosphorylation site [posttranslational modification]
653938000759	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938000760	active site
653938000761	phosphorylation site [posttranslational modification]
653938000762	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938000763	active site
653938000764	phosphorylation site [posttranslational modification]
653938000765	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
653938000766	active site
653938000767	P-loop; other site
653938000768	phosphorylation site [posttranslational modification]
653938000769	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
653938000770	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
653938000771	active site
653938000772	substrate binding pocket [chemical binding]; other site
653938000773	homodimer interaction site [polypeptide binding]; other site
653938000774	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
653938000775	Protein of unknown function (DUF1341); Region: DUF1341; cl06211
653938000776	hypothetical protein; Provisional; Region: PRK02947
653938000777	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
653938000778	putative active site [active]
653938000779	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
653938000780	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
653938000781	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
653938000782	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
653938000783	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
653938000784	active site
653938000785	metal binding site [ion binding]; metal-binding site
653938000786	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
653938000787	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
653938000788	substrate binding pocket [chemical binding]; other site
653938000789	chain length determination region; other site
653938000790	substrate-Mg2+ binding site; other site
653938000791	catalytic residues [active]
653938000792	aspartate-rich region 1; other site
653938000793	active site lid residues [active]
653938000794	aspartate-rich region 2; other site
653938000795	Predicted membrane protein [Function unknown]; Region: COG4769
653938000796	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
653938000797	trimer interface [polypeptide binding]; other site
653938000798	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
653938000799	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653938000800	Predicted membrane protein [Function unknown]; Region: COG2259
653938000801	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
653938000802	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
653938000803	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
653938000804	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
653938000805	ApbE family; Region: ApbE; pfam02424
653938000806	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387
653938000807	UbiA prenyltransferase family; Region: UbiA; pfam01040
653938000808	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
653938000809	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
653938000810	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
653938000811	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
653938000812	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
653938000813	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
653938000814	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
653938000815	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
653938000816	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
653938000817	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
653938000818	putative translocon binding site; other site
653938000819	protein-rRNA interface [nucleotide binding]; other site
653938000820	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
653938000821	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
653938000822	G-X-X-G motif; other site
653938000823	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
653938000824	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
653938000825	23S rRNA interface [nucleotide binding]; other site
653938000826	5S rRNA interface [nucleotide binding]; other site
653938000827	putative antibiotic binding site [chemical binding]; other site
653938000828	L25 interface [polypeptide binding]; other site
653938000829	L27 interface [polypeptide binding]; other site
653938000830	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
653938000831	23S rRNA interface [nucleotide binding]; other site
653938000832	putative translocon interaction site; other site
653938000833	signal recognition particle (SRP54) interaction site; other site
653938000834	L23 interface [polypeptide binding]; other site
653938000835	trigger factor interaction site; other site
653938000836	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
653938000837	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
653938000838	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
653938000839	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
653938000840	RNA binding site [nucleotide binding]; other site
653938000841	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
653938000842	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
653938000843	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
653938000844	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
653938000845	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
653938000846	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
653938000847	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
653938000848	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
653938000849	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
653938000850	5S rRNA interface [nucleotide binding]; other site
653938000851	L27 interface [polypeptide binding]; other site
653938000852	23S rRNA interface [nucleotide binding]; other site
653938000853	L5 interface [polypeptide binding]; other site
653938000854	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
653938000855	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
653938000856	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
653938000857	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
653938000858	23S rRNA binding site [nucleotide binding]; other site
653938000859	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
653938000860	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
653938000861	SecY translocase; Region: SecY; pfam00344
653938000862	adenylate kinase; Reviewed; Region: adk; PRK00279
653938000863	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
653938000864	AMP-binding site [chemical binding]; other site
653938000865	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
653938000866	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
653938000867	rRNA binding site [nucleotide binding]; other site
653938000868	predicted 30S ribosome binding site; other site
653938000869	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
653938000870	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
653938000871	30S ribosomal protein S13; Region: bact_S13; TIGR03631
653938000872	30S ribosomal protein S11; Validated; Region: PRK05309
653938000873	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
653938000874	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
653938000875	alphaNTD - beta interaction site [polypeptide binding]; other site
653938000876	alphaNTD homodimer interface [polypeptide binding]; other site
653938000877	alphaNTD - beta' interaction site [polypeptide binding]; other site
653938000878	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
653938000879	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
653938000880	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
653938000881	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
653938000882	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
653938000883	MgtC family; Region: MgtC; pfam02308
653938000884	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
653938000885	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
653938000886	Walker A/P-loop; other site
653938000887	ATP binding site [chemical binding]; other site
653938000888	Q-loop/lid; other site
653938000889	ABC transporter signature motif; other site
653938000890	Walker B; other site
653938000891	D-loop; other site
653938000892	H-loop/switch region; other site
653938000893	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
653938000894	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
653938000895	Walker A/P-loop; other site
653938000896	ATP binding site [chemical binding]; other site
653938000897	Q-loop/lid; other site
653938000898	ABC transporter signature motif; other site
653938000899	Walker B; other site
653938000900	D-loop; other site
653938000901	H-loop/switch region; other site
653938000902	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
653938000903	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
653938000904	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
653938000905	dimerization interface 3.5A [polypeptide binding]; other site
653938000906	active site
653938000907	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
653938000908	23S rRNA interface [nucleotide binding]; other site
653938000909	L3 interface [polypeptide binding]; other site
653938000910	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
653938000911	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
653938000912	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
653938000913	DNA binding residues [nucleotide binding]
653938000914	putative dimer interface [polypeptide binding]; other site
653938000915	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
653938000916	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
653938000917	active site
653938000918	catalytic tetrad [active]
653938000919	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
653938000920	SH3-like domain; Region: SH3_8; pfam13457
653938000921	SH3-like domain; Region: SH3_8; pfam13457
653938000922	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
653938000923	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
653938000924	Walker A motif; other site
653938000925	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
653938000926	UvrB/uvrC motif; Region: UVR; pfam02151
653938000927	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
653938000928	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
653938000929	ADP binding site [chemical binding]; other site
653938000930	phosphagen binding site; other site
653938000931	substrate specificity loop; other site
653938000932	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
653938000933	Clp amino terminal domain; Region: Clp_N; pfam02861
653938000934	Clp amino terminal domain; Region: Clp_N; pfam02861
653938000935	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938000936	Walker A motif; other site
653938000937	ATP binding site [chemical binding]; other site
653938000938	Walker B motif; other site
653938000939	arginine finger; other site
653938000940	UvrB/uvrC motif; Region: UVR; pfam02151
653938000941	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938000942	Walker A motif; other site
653938000943	ATP binding site [chemical binding]; other site
653938000944	Walker B motif; other site
653938000945	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
653938000946	DNA repair protein RadA; Provisional; Region: PRK11823
653938000947	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
653938000948	Walker A motif/ATP binding site; other site
653938000949	ATP binding site [chemical binding]; other site
653938000950	Walker B motif; other site
653938000951	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
653938000952	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
653938000953	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
653938000954	putative active site [active]
653938000955	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
653938000956	substrate binding site; other site
653938000957	dimer interface; other site
653938000958	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
653938000959	homotrimer interaction site [polypeptide binding]; other site
653938000960	zinc binding site [ion binding]; other site
653938000961	CDP-binding sites; other site
653938000962	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
653938000963	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
653938000964	HIGH motif; other site
653938000965	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
653938000966	active site
653938000967	KMSKS motif; other site
653938000968	serine O-acetyltransferase; Region: cysE; TIGR01172
653938000969	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
653938000970	trimer interface [polypeptide binding]; other site
653938000971	active site
653938000972	substrate binding site [chemical binding]; other site
653938000973	CoA binding site [chemical binding]; other site
653938000974	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
653938000975	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
653938000976	active site
653938000977	HIGH motif; other site
653938000978	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
653938000979	KMSKS motif; other site
653938000980	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
653938000981	tRNA binding surface [nucleotide binding]; other site
653938000982	anticodon binding site; other site
653938000983	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
653938000984	active site
653938000985	metal binding site [ion binding]; metal-binding site
653938000986	dimerization interface [polypeptide binding]; other site
653938000987	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
653938000988	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
653938000989	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
653938000990	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
653938000991	RNA polymerase factor sigma-70; Validated; Region: PRK08295
653938000992	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
653938000993	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
653938000994	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
653938000995	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
653938000996	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
653938000997	putative homodimer interface [polypeptide binding]; other site
653938000998	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
653938000999	heterodimer interface [polypeptide binding]; other site
653938001000	homodimer interface [polypeptide binding]; other site
653938001001	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
653938001002	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
653938001003	23S rRNA interface [nucleotide binding]; other site
653938001004	L7/L12 interface [polypeptide binding]; other site
653938001005	putative thiostrepton binding site; other site
653938001006	L25 interface [polypeptide binding]; other site
653938001007	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
653938001008	mRNA/rRNA interface [nucleotide binding]; other site
653938001009	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
653938001010	23S rRNA interface [nucleotide binding]; other site
653938001011	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
653938001012	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
653938001013	core dimer interface [polypeptide binding]; other site
653938001014	peripheral dimer interface [polypeptide binding]; other site
653938001015	L10 interface [polypeptide binding]; other site
653938001016	L11 interface [polypeptide binding]; other site
653938001017	putative EF-Tu interaction site [polypeptide binding]; other site
653938001018	putative EF-G interaction site [polypeptide binding]; other site
653938001019	Protein of unknown function (DUF1307); Region: DUF1307; cl01981
653938001020	Methyltransferase domain; Region: Methyltransf_31; pfam13847
653938001021	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938001022	S-adenosylmethionine binding site [chemical binding]; other site
653938001023	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
653938001024	Transcriptional regulators [Transcription]; Region: PurR; COG1609
653938001025	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
653938001026	DNA binding site [nucleotide binding]
653938001027	domain linker motif; other site
653938001028	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
653938001029	putative dimerization interface [polypeptide binding]; other site
653938001030	putative ligand binding site [chemical binding]; other site
653938001031	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
653938001032	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
653938001033	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
653938001034	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938001035	dimer interface [polypeptide binding]; other site
653938001036	conserved gate region; other site
653938001037	putative PBP binding loops; other site
653938001038	ABC-ATPase subunit interface; other site
653938001039	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
653938001040	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938001041	dimer interface [polypeptide binding]; other site
653938001042	conserved gate region; other site
653938001043	putative PBP binding loops; other site
653938001044	ABC-ATPase subunit interface; other site
653938001045	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
653938001046	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
653938001047	Ca binding site [ion binding]; other site
653938001048	active site
653938001049	catalytic site [active]
653938001050	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
653938001051	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
653938001052	active site
653938001053	homodimer interface [polypeptide binding]; other site
653938001054	catalytic site [active]
653938001055	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
653938001056	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
653938001057	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
653938001058	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
653938001059	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
653938001060	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
653938001061	RPB10 interaction site [polypeptide binding]; other site
653938001062	RPB1 interaction site [polypeptide binding]; other site
653938001063	RPB11 interaction site [polypeptide binding]; other site
653938001064	RPB3 interaction site [polypeptide binding]; other site
653938001065	RPB12 interaction site [polypeptide binding]; other site
653938001066	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
653938001067	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
653938001068	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
653938001069	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
653938001070	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
653938001071	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
653938001072	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
653938001073	G-loop; other site
653938001074	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
653938001075	DNA binding site [nucleotide binding]
653938001076	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
653938001077	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
653938001078	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938001079	active site
653938001080	motif I; other site
653938001081	motif II; other site
653938001082	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
653938001083	beta-galactosidase; Region: BGL; TIGR03356
653938001084	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
653938001085	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
653938001086	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001087	Substrate binding site [chemical binding]; other site
653938001088	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001089	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001090	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001091	LRR adjacent; Region: LRR_adjacent; pfam08191
653938001092	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
653938001093	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
653938001094	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
653938001095	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
653938001096	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
653938001097	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001098	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001099	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001100	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001101	LRR adjacent; Region: LRR_adjacent; pfam08191
653938001102	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
653938001103	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
653938001104	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
653938001105	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
653938001106	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001107	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001108	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001109	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001110	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001111	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001112	LRR adjacent; Region: LRR_adjacent; pfam08191
653938001113	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
653938001114	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
653938001115	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
653938001116	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001117	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001118	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001119	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001120	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001121	LRR adjacent; Region: LRR_adjacent; pfam08191
653938001122	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
653938001123	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
653938001124	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
653938001125	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
653938001126	metal binding site [ion binding]; metal-binding site
653938001127	dimer interface [polypeptide binding]; other site
653938001128	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
653938001129	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
653938001130	putative Zn2+ binding site [ion binding]; other site
653938001131	putative DNA binding site [nucleotide binding]; other site
653938001132	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
653938001133	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
653938001134	Zn binding site [ion binding]; other site
653938001135	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
653938001136	Zn binding site [ion binding]; other site
653938001137	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
653938001138	catalytic core [active]
653938001139	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
653938001140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938001141	dimer interface [polypeptide binding]; other site
653938001142	conserved gate region; other site
653938001143	putative PBP binding loops; other site
653938001144	ABC-ATPase subunit interface; other site
653938001145	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
653938001146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938001147	dimer interface [polypeptide binding]; other site
653938001148	conserved gate region; other site
653938001149	ABC-ATPase subunit interface; other site
653938001150	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
653938001151	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
653938001152	beta-galactosidase; Region: BGL; TIGR03356
653938001153	sugar phosphate phosphatase; Provisional; Region: PRK10513
653938001154	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938001155	active site
653938001156	motif I; other site
653938001157	motif II; other site
653938001158	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938001159	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938001160	Coenzyme A binding pocket [chemical binding]; other site
653938001161	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938001162	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
653938001163	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
653938001164	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
653938001165	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938001166	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
653938001167	active site
653938001168	motif I; other site
653938001169	motif II; other site
653938001170	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938001171	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
653938001172	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
653938001173	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
653938001174	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
653938001175	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
653938001176	Walker A/P-loop; other site
653938001177	ATP binding site [chemical binding]; other site
653938001178	Q-loop/lid; other site
653938001179	ABC transporter signature motif; other site
653938001180	Walker B; other site
653938001181	D-loop; other site
653938001182	H-loop/switch region; other site
653938001183	TOBE domain; Region: TOBE; pfam03459
653938001184	ATP cone domain; Region: ATP-cone; pfam03477
653938001185	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
653938001186	Class III ribonucleotide reductase; Region: RNR_III; cd01675
653938001187	effector binding site; other site
653938001188	active site
653938001189	Zn binding site [ion binding]; other site
653938001190	glycine loop; other site
653938001191	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
653938001192	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
653938001193	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938001194	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
653938001195	ligand binding site [chemical binding]; other site
653938001196	flexible hinge region; other site
653938001197	Predicted amidohydrolase [General function prediction only]; Region: COG0388
653938001198	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
653938001199	putative active site [active]
653938001200	catalytic triad [active]
653938001201	putative dimer interface [polypeptide binding]; other site
653938001202	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938001203	dimer interface [polypeptide binding]; other site
653938001204	conserved gate region; other site
653938001205	ABC-ATPase subunit interface; other site
653938001206	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
653938001207	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
653938001208	Walker A/P-loop; other site
653938001209	ATP binding site [chemical binding]; other site
653938001210	Q-loop/lid; other site
653938001211	ABC transporter signature motif; other site
653938001212	Walker B; other site
653938001213	D-loop; other site
653938001214	H-loop/switch region; other site
653938001215	NIL domain; Region: NIL; pfam09383
653938001216	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
653938001217	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
653938001218	transaminase; Reviewed; Region: PRK08068
653938001219	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
653938001220	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938001221	homodimer interface [polypeptide binding]; other site
653938001222	catalytic residue [active]
653938001223	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
653938001224	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938001225	active site
653938001226	phosphorylation site [posttranslational modification]
653938001227	intermolecular recognition site; other site
653938001228	dimerization interface [polypeptide binding]; other site
653938001229	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
653938001230	DNA binding site [nucleotide binding]
653938001231	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
653938001232	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653938001233	dimerization interface [polypeptide binding]; other site
653938001234	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653938001235	putative active site [active]
653938001236	heme pocket [chemical binding]; other site
653938001237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653938001238	dimer interface [polypeptide binding]; other site
653938001239	phosphorylation site [posttranslational modification]
653938001240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938001241	ATP binding site [chemical binding]; other site
653938001242	Mg2+ binding site [ion binding]; other site
653938001243	G-X-G motif; other site
653938001244	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
653938001245	YycH protein; Region: YycH; pfam07435
653938001246	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853
653938001247	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
653938001248	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
653938001249	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
653938001250	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
653938001251	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
653938001252	protein binding site [polypeptide binding]; other site
653938001253	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
653938001254	Transcriptional regulator [Transcription]; Region: LysR; COG0583
653938001255	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
653938001256	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
653938001257	dimerization interface [polypeptide binding]; other site
653938001258	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
653938001259	dimer interface [polypeptide binding]; other site
653938001260	FMN binding site [chemical binding]; other site
653938001261	NADPH bind site [chemical binding]; other site
653938001262	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
653938001263	HTH domain; Region: HTH_11; pfam08279
653938001264	Mga helix-turn-helix domain; Region: Mga; pfam05043
653938001265	PRD domain; Region: PRD; pfam00874
653938001266	PRD domain; Region: PRD; pfam00874
653938001267	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
653938001268	active site
653938001269	P-loop; other site
653938001270	phosphorylation site [posttranslational modification]
653938001271	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938001272	active site
653938001273	phosphorylation site [posttranslational modification]
653938001274	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
653938001275	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
653938001276	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
653938001277	active site
653938001278	P-loop; other site
653938001279	phosphorylation site [posttranslational modification]
653938001280	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
653938001281	beta-galactosidase; Region: BGL; TIGR03356
653938001282	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
653938001283	methionine cluster; other site
653938001284	active site
653938001285	phosphorylation site [posttranslational modification]
653938001286	metal binding site [ion binding]; metal-binding site
653938001287	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
653938001288	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
653938001289	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
653938001290	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
653938001291	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
653938001292	catalytic residue [active]
653938001293	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805
653938001294	putative active site [active]
653938001295	YdjC motif; other site
653938001296	Mg binding site [ion binding]; other site
653938001297	putative homodimer interface [polypeptide binding]; other site
653938001298	Putative transcription activator [Transcription]; Region: TenA; COG0819
653938001299	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
653938001300	substrate binding site [chemical binding]; other site
653938001301	multimerization interface [polypeptide binding]; other site
653938001302	ATP binding site [chemical binding]; other site
653938001303	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
653938001304	dimer interface [polypeptide binding]; other site
653938001305	substrate binding site [chemical binding]; other site
653938001306	ATP binding site [chemical binding]; other site
653938001307	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
653938001308	thiamine phosphate binding site [chemical binding]; other site
653938001309	active site
653938001310	pyrophosphate binding site [ion binding]; other site
653938001311	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
653938001312	beta-galactosidase; Region: BGL; TIGR03356
653938001313	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
653938001314	Protein of unknown function (DUF1696); Region: DUF1696; pfam08000
653938001315	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
653938001316	putative catalytic site [active]
653938001317	putative metal binding site [ion binding]; other site
653938001318	putative phosphate binding site [ion binding]; other site
653938001319	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938001320	non-specific DNA binding site [nucleotide binding]; other site
653938001321	salt bridge; other site
653938001322	sequence-specific DNA binding site [nucleotide binding]; other site
653938001323	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
653938001324	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938001325	non-specific DNA binding site [nucleotide binding]; other site
653938001326	salt bridge; other site
653938001327	sequence-specific DNA binding site [nucleotide binding]; other site
653938001328	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
653938001329	Leucine rich repeat; Region: LRR_8; pfam13855
653938001330	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001331	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001332	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001333	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001334	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001335	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001336	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001337	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001338	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001339	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001340	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001341	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001342	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001343	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001344	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001345	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001346	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
653938001347	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
653938001348	Leucine-rich repeats; other site
653938001349	Substrate binding site [chemical binding]; other site
653938001350	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001351	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001352	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001353	Leucine rich repeat; Region: LRR_8; pfam13855
653938001354	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
653938001355	Leucine-rich repeats; other site
653938001356	Substrate binding site [chemical binding]; other site
653938001357	Leucine rich repeat; Region: LRR_8; pfam13855
653938001358	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001359	Leucine rich repeat; Region: LRR_8; pfam13855
653938001360	Leucine rich repeat; Region: LRR_8; pfam13855
653938001361	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001362	LRR adjacent; Region: LRR_adjacent; pfam08191
653938001363	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001364	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001365	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001366	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
653938001367	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
653938001368	Enterocin A Immunity; Region: EntA_Immun; pfam08951
653938001369	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
653938001370	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
653938001371	TPP-binding site [chemical binding]; other site
653938001372	dimer interface [polypeptide binding]; other site
653938001373	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
653938001374	PYR/PP interface [polypeptide binding]; other site
653938001375	dimer interface [polypeptide binding]; other site
653938001376	TPP binding site [chemical binding]; other site
653938001377	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
653938001378	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
653938001379	active site
653938001380	intersubunit interactions; other site
653938001381	catalytic residue [active]
653938001382	short chain dehydrogenase; Provisional; Region: PRK06841
653938001383	classical (c) SDRs; Region: SDR_c; cd05233
653938001384	NAD(P) binding site [chemical binding]; other site
653938001385	active site
653938001386	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
653938001387	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
653938001388	substrate binding site [chemical binding]; other site
653938001389	dimer interface [polypeptide binding]; other site
653938001390	catalytic triad [active]
653938001391	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
653938001392	DAK2 domain; Region: Dak2; cl03685
653938001393	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
653938001394	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
653938001395	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
653938001396	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
653938001397	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
653938001398	putative DNA binding site [nucleotide binding]; other site
653938001399	putative Zn2+ binding site [ion binding]; other site
653938001400	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
653938001401	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938001402	Coenzyme A binding pocket [chemical binding]; other site
653938001403	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
653938001404	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
653938001405	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
653938001406	acyl-activating enzyme (AAE) consensus motif; other site
653938001407	acyl-activating enzyme (AAE) consensus motif; other site
653938001408	AMP binding site [chemical binding]; other site
653938001409	active site
653938001410	CoA binding site [chemical binding]; other site
653938001411	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
653938001412	L-aspartate oxidase; Provisional; Region: PRK06175
653938001413	putative oxidoreductase; Provisional; Region: PRK10206
653938001414	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
653938001415	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
653938001416	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938001417	active site
653938001418	phosphorylation site [posttranslational modification]
653938001419	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
653938001420	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
653938001421	active site
653938001422	P-loop; other site
653938001423	phosphorylation site [posttranslational modification]
653938001424	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
653938001425	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
653938001426	intersubunit interface [polypeptide binding]; other site
653938001427	active site
653938001428	zinc binding site [ion binding]; other site
653938001429	Na+ binding site [ion binding]; other site
653938001430	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
653938001431	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
653938001432	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
653938001433	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
653938001434	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
653938001435	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
653938001436	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
653938001437	Imelysin; Region: Peptidase_M75; pfam09375
653938001438	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
653938001439	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
653938001440	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693
653938001441	nudix motif; other site
653938001442	hypothetical protein; Provisional; Region: PRK12378
653938001443	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
653938001444	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
653938001445	PhnA protein; Region: PhnA; pfam03831
653938001446	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
653938001447	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938001448	DNA-binding site [nucleotide binding]; DNA binding site
653938001449	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
653938001450	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
653938001451	beta-galactosidase; Region: BGL; TIGR03356
653938001452	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
653938001453	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
653938001454	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
653938001455	active site
653938001456	P-loop; other site
653938001457	phosphorylation site [posttranslational modification]
653938001458	Predicted transcriptional regulator [Transcription]; Region: COG2378
653938001459	HTH domain; Region: HTH_11; pfam08279
653938001460	WYL domain; Region: WYL; pfam13280
653938001461	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
653938001462	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
653938001463	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
653938001464	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
653938001465	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
653938001466	tetrameric interface [polypeptide binding]; other site
653938001467	NAD binding site [chemical binding]; other site
653938001468	catalytic residues [active]
653938001469	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
653938001470	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
653938001471	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
653938001472	substrate binding site [chemical binding]; other site
653938001473	ATP binding site [chemical binding]; other site
653938001474	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
653938001475	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
653938001476	PYR/PP interface [polypeptide binding]; other site
653938001477	dimer interface [polypeptide binding]; other site
653938001478	TPP binding site [chemical binding]; other site
653938001479	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
653938001480	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
653938001481	TPP-binding site; other site
653938001482	Uncharacterized conserved protein [Function unknown]; Region: COG5646
653938001483	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
653938001484	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
653938001485	ligand binding site [chemical binding]; other site
653938001486	active site
653938001487	UGI interface [polypeptide binding]; other site
653938001488	catalytic site [active]
653938001489	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
653938001490	hypothetical protein; Provisional; Region: PRK13665
653938001491	Bacterial SH3 domain; Region: SH3_3; cl17532
653938001492	NlpC/P60 family; Region: NLPC_P60; pfam00877
653938001493	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
653938001494	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938001495	Coenzyme A binding pocket [chemical binding]; other site
653938001496	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
653938001497	pyrroline-5-carboxylate reductase; Region: PLN02688
653938001498	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
653938001499	putative hydrophobic ligand binding site [chemical binding]; other site
653938001500	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938001501	active site
653938001502	phosphorylation site [posttranslational modification]
653938001503	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
653938001504	active site
653938001505	P-loop; other site
653938001506	phosphorylation site [posttranslational modification]
653938001507	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
653938001508	alpha-mannosidase; Provisional; Region: PRK09819
653938001509	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
653938001510	active site
653938001511	metal binding site [ion binding]; metal-binding site
653938001512	catalytic site [active]
653938001513	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
653938001514	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
653938001515	HTH domain; Region: HTH_11; pfam08279
653938001516	Mga helix-turn-helix domain; Region: Mga; pfam05043
653938001517	PRD domain; Region: PRD; pfam00874
653938001518	PRD domain; Region: PRD; pfam00874
653938001519	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
653938001520	active site
653938001521	P-loop; other site
653938001522	phosphorylation site [posttranslational modification]
653938001523	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938001524	active site
653938001525	phosphorylation site [posttranslational modification]
653938001526	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
653938001527	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
653938001528	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
653938001529	putative metal binding site [ion binding]; other site
653938001530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835
653938001531	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
653938001532	trimer interface [polypeptide binding]; other site
653938001533	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
653938001534	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
653938001535	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
653938001536	Leucine-rich repeats; other site
653938001537	Substrate binding site [chemical binding]; other site
653938001538	LRR adjacent; Region: LRR_adjacent; pfam08191
653938001539	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
653938001540	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
653938001541	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
653938001542	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
653938001543	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
653938001544	phosphoenolpyruvate synthase; Validated; Region: PRK06241
653938001545	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
653938001546	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
653938001547	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
653938001548	ZIP Zinc transporter; Region: Zip; pfam02535
653938001549	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
653938001550	Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954
653938001551	NodB motif; other site
653938001552	active site
653938001553	catalytic site [active]
653938001554	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938001555	salt bridge; other site
653938001556	non-specific DNA binding site [nucleotide binding]; other site
653938001557	sequence-specific DNA binding site [nucleotide binding]; other site
653938001558	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
653938001559	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938001560	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
653938001561	active site
653938001562	motif I; other site
653938001563	motif II; other site
653938001564	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938001565	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
653938001566	lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416
653938001567	Predicted transcriptional regulators [Transcription]; Region: COG1695
653938001568	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
653938001569	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
653938001570	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
653938001571	DNA binding residues [nucleotide binding]
653938001572	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
653938001573	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
653938001574	HTH domain; Region: HTH_11; pfam08279
653938001575	PRD domain; Region: PRD; pfam00874
653938001576	PRD domain; Region: PRD; pfam00874
653938001577	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
653938001578	active site
653938001579	P-loop; other site
653938001580	phosphorylation site [posttranslational modification]
653938001581	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938001582	active site
653938001583	phosphorylation site [posttranslational modification]
653938001584	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938001585	active site
653938001586	phosphorylation site [posttranslational modification]
653938001587	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
653938001588	active site
653938001589	P-loop; other site
653938001590	phosphorylation site [posttranslational modification]
653938001591	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
653938001592	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
653938001593	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
653938001594	active site
653938001595	metal binding site [ion binding]; metal-binding site
653938001596	catalytic site [active]
653938001597	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
653938001598	Transcriptional regulator [Transcription]; Region: LysR; COG0583
653938001599	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
653938001600	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
653938001601	dimerization interface [polypeptide binding]; other site
653938001602	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
653938001603	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
653938001604	active site
653938001605	substrate binding site [chemical binding]; other site
653938001606	trimer interface [polypeptide binding]; other site
653938001607	CoA binding site [chemical binding]; other site
653938001608	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
653938001609	classical (c) SDRs; Region: SDR_c; cd05233
653938001610	NAD(P) binding site [chemical binding]; other site
653938001611	active site
653938001612	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
653938001613	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001614	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
653938001615	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001616	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001617	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001618	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001619	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001620	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001621	LRR adjacent; Region: LRR_adjacent; pfam08191
653938001622	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
653938001623	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
653938001624	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
653938001625	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
653938001626	Leucine rich repeat; Region: LRR_8; pfam13855
653938001627	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
653938001628	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001629	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001630	LRR adjacent; Region: LRR_adjacent; pfam08191
653938001631	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
653938001632	SH3-like domain; Region: SH3_8; pfam13457
653938001633	Predicted transcriptional regulator [Transcription]; Region: COG1959
653938001634	Transcriptional regulator; Region: Rrf2; pfam02082
653938001635	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
653938001636	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
653938001637	NAD(P) binding site [chemical binding]; other site
653938001638	active site
653938001639	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
653938001640	Protein of unknown function (DUF2004); Region: DUF2004; pfam09406
653938001641	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
653938001642	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
653938001643	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
653938001644	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
653938001645	Transcriptional regulator [Transcription]; Region: LytR; COG1316
653938001646	Predicted membrane protein [Function unknown]; Region: COG1511
653938001647	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
653938001648	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
653938001649	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
653938001650	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
653938001651	Mga helix-turn-helix domain; Region: Mga; pfam05043
653938001652	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
653938001653	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
653938001654	active site
653938001655	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
653938001656	L-tyrosine decarboxylase; Provisional; Region: PRK13520
653938001657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938001658	catalytic residue [active]
653938001659	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
653938001660	Signal peptide peptidase; Region: Peptidase_A22B; cl01342
653938001661	Predicted membrane protein [Function unknown]; Region: COG3619
653938001662	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
653938001663	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
653938001664	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
653938001665	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
653938001666	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
653938001667	Protein of unknown function DUF58; Region: DUF58; pfam01882
653938001668	MoxR-like ATPases [General function prediction only]; Region: COG0714
653938001669	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938001670	Walker A motif; other site
653938001671	ATP binding site [chemical binding]; other site
653938001672	Walker B motif; other site
653938001673	arginine finger; other site
653938001674	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
653938001675	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
653938001676	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
653938001677	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
653938001678	Na binding site [ion binding]; other site
653938001679	Uncharacterized conserved protein [Function unknown]; Region: COG3535
653938001680	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
653938001681	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
653938001682	nucleotide binding site [chemical binding]; other site
653938001683	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
653938001684	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
653938001685	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
653938001686	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653938001687	Zn2+ binding site [ion binding]; other site
653938001688	Mg2+ binding site [ion binding]; other site
653938001689	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
653938001690	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
653938001691	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
653938001692	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
653938001693	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
653938001694	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
653938001695	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
653938001696	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653938001697	FeS/SAM binding site; other site
653938001698	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
653938001699	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316
653938001700	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
653938001701	putative FMN binding site [chemical binding]; other site
653938001702	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
653938001703	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
653938001704	nudix motif; other site
653938001705	Transcriptional regulator [Transcription]; Region: LysR; COG0583
653938001706	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
653938001707	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
653938001708	putative dimerization interface [polypeptide binding]; other site
653938001709	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
653938001710	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
653938001711	active site
653938001712	FMN binding site [chemical binding]; other site
653938001713	substrate binding site [chemical binding]; other site
653938001714	putative catalytic residue [active]
653938001715	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
653938001716	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653938001717	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653938001718	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
653938001719	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
653938001720	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
653938001721	shikimate binding site; other site
653938001722	NAD(P) binding site [chemical binding]; other site
653938001723	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
653938001724	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
653938001725	active site
653938001726	catalytic residue [active]
653938001727	dimer interface [polypeptide binding]; other site
653938001728	Transcriptional regulator [Transcription]; Region: LysR; COG0583
653938001729	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
653938001730	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
653938001731	dimerization interface [polypeptide binding]; other site
653938001732	substrate binding pocket [chemical binding]; other site
653938001733	Predicted acyl esterases [General function prediction only]; Region: COG2936
653938001734	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
653938001735	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
653938001736	active site
653938001737	catalytic triad [active]
653938001738	oxyanion hole [active]
653938001739	EamA-like transporter family; Region: EamA; pfam00892
653938001740	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
653938001741	EamA-like transporter family; Region: EamA; pfam00892
653938001742	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
653938001743	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
653938001744	active site
653938001745	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
653938001746	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
653938001747	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
653938001748	substrate binding site [chemical binding]; other site
653938001749	hexamer interface [polypeptide binding]; other site
653938001750	metal binding site [ion binding]; metal-binding site
653938001751	Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176
653938001752	catalytic residue [active]
653938001753	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
653938001754	PRD domain; Region: PRD; pfam00874
653938001755	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
653938001756	active site
653938001757	P-loop; other site
653938001758	phosphorylation site [posttranslational modification]
653938001759	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938001760	active site
653938001761	phosphorylation site [posttranslational modification]
653938001762	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
653938001763	putative active site [active]
653938001764	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938001765	active site
653938001766	phosphorylation site [posttranslational modification]
653938001767	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
653938001768	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
653938001769	substrate binding site [chemical binding]; other site
653938001770	hexamer interface [polypeptide binding]; other site
653938001771	metal binding site [ion binding]; metal-binding site
653938001772	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
653938001773	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
653938001774	putative NAD(P) binding site [chemical binding]; other site
653938001775	catalytic Zn binding site [ion binding]; other site
653938001776	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
653938001777	active site
653938001778	P-loop; other site
653938001779	phosphorylation site [posttranslational modification]
653938001780	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
653938001781	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
653938001782	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
653938001783	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
653938001784	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653938001785	active site
653938001786	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
653938001787	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
653938001788	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
653938001789	catalytic triad [active]
653938001790	conserved hypothetical protein; Region: lin0512_fam; TIGR02058
653938001791	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
653938001792	MarR family; Region: MarR_2; pfam12802
653938001793	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938001794	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
653938001795	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
653938001796	Ligand Binding Site [chemical binding]; other site
653938001797	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
653938001798	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
653938001799	putative active site [active]
653938001800	putative metal binding site [ion binding]; other site
653938001801	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
653938001802	catalytic core [active]
653938001803	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
653938001804	Predicted membrane protein [Function unknown]; Region: COG3759
653938001805	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938001806	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653938001807	putative substrate translocation pore; other site
653938001808	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
653938001809	non-specific DNA interactions [nucleotide binding]; other site
653938001810	DNA binding site [nucleotide binding]
653938001811	sequence specific DNA binding site [nucleotide binding]; other site
653938001812	putative cAMP binding site [chemical binding]; other site
653938001813	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
653938001814	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
653938001815	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
653938001816	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
653938001817	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653938001818	ATP binding site [chemical binding]; other site
653938001819	putative Mg++ binding site [ion binding]; other site
653938001820	HsdM N-terminal domain; Region: HsdM_N; pfam12161
653938001821	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
653938001822	Methyltransferase domain; Region: Methyltransf_26; pfam13659
653938001823	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
653938001824	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
653938001825	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
653938001826	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
653938001827	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
653938001828	Int/Topo IB signature motif; other site
653938001829	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
653938001830	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
653938001831	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
653938001832	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
653938001833	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
653938001834	NAD binding site [chemical binding]; other site
653938001835	sugar binding site [chemical binding]; other site
653938001836	divalent metal binding site [ion binding]; other site
653938001837	tetramer (dimer of dimers) interface [polypeptide binding]; other site
653938001838	dimer interface [polypeptide binding]; other site
653938001839	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
653938001840	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
653938001841	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
653938001842	putative active site [active]
653938001843	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
653938001844	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
653938001845	Sulfate transporter family; Region: Sulfate_transp; pfam00916
653938001846	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
653938001847	Uncharacterized conserved protein [Function unknown]; Region: COG5361
653938001848	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
653938001849	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
653938001850	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
653938001851	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
653938001852	DNA binding residues [nucleotide binding]
653938001853	dimer interface [polypeptide binding]; other site
653938001854	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
653938001855	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
653938001856	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
653938001857	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
653938001858	DXD motif; other site
653938001859	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
653938001860	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
653938001861	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653938001862	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938001863	S-adenosylmethionine binding site [chemical binding]; other site
653938001864	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
653938001865	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
653938001866	Transcriptional regulators [Transcription]; Region: PurR; COG1609
653938001867	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
653938001868	DNA binding site [nucleotide binding]
653938001869	domain linker motif; other site
653938001870	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
653938001871	putative dimerization interface [polypeptide binding]; other site
653938001872	putative ligand binding site [chemical binding]; other site
653938001873	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
653938001874	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
653938001875	NAD binding site [chemical binding]; other site
653938001876	sugar binding site [chemical binding]; other site
653938001877	divalent metal binding site [ion binding]; other site
653938001878	tetramer (dimer of dimers) interface [polypeptide binding]; other site
653938001879	dimer interface [polypeptide binding]; other site
653938001880	allantoate amidohydrolase; Reviewed; Region: PRK09290
653938001881	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
653938001882	active site
653938001883	metal binding site [ion binding]; metal-binding site
653938001884	dimer interface [polypeptide binding]; other site
653938001885	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
653938001886	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
653938001887	metal binding site [ion binding]; metal-binding site
653938001888	putative dimer interface [polypeptide binding]; other site
653938001889	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
653938001890	Beta-lactamase; Region: Beta-lactamase; pfam00144
653938001891	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
653938001892	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
653938001893	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
653938001894	intersubunit interface [polypeptide binding]; other site
653938001895	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
653938001896	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
653938001897	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
653938001898	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
653938001899	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
653938001900	Glucitol operon activator protein (GutM); Region: GutM; cl01890
653938001901	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
653938001902	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
653938001903	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
653938001904	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
653938001905	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
653938001906	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938001907	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
653938001908	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
653938001909	WxL domain surface cell wall-binding; Region: WxL; pfam13731
653938001910	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
653938001911	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
653938001912	FOG: CBS domain [General function prediction only]; Region: COG0517
653938001913	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
653938001914	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
653938001915	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
653938001916	dimer interface [polypeptide binding]; other site
653938001917	active site
653938001918	metal binding site [ion binding]; metal-binding site
653938001919	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
653938001920	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938001921	putative substrate translocation pore; other site
653938001922	POT family; Region: PTR2; pfam00854
653938001923	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
653938001924	catalytic core [active]
653938001925	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
653938001926	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
653938001927	catalytic core [active]
653938001928	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
653938001929	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
653938001930	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
653938001931	Cl binding site [ion binding]; other site
653938001932	oligomer interface [polypeptide binding]; other site
653938001933	glutamate dehydrogenase; Provisional; Region: PRK09414
653938001934	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
653938001935	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
653938001936	NAD(P) binding site [chemical binding]; other site
653938001937	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
653938001938	metal binding site [ion binding]; metal-binding site
653938001939	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
653938001940	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
653938001941	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
653938001942	substrate binding site [chemical binding]; other site
653938001943	glutamase interaction surface [polypeptide binding]; other site
653938001944	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
653938001945	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
653938001946	catalytic residues [active]
653938001947	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
653938001948	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
653938001949	putative active site [active]
653938001950	oxyanion strand; other site
653938001951	catalytic triad [active]
653938001952	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
653938001953	putative active site pocket [active]
653938001954	4-fold oligomerization interface [polypeptide binding]; other site
653938001955	metal binding residues [ion binding]; metal-binding site
653938001956	3-fold/trimer interface [polypeptide binding]; other site
653938001957	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
653938001958	histidinol dehydrogenase; Region: hisD; TIGR00069
653938001959	NAD binding site [chemical binding]; other site
653938001960	dimerization interface [polypeptide binding]; other site
653938001961	product binding site; other site
653938001962	substrate binding site [chemical binding]; other site
653938001963	zinc binding site [ion binding]; other site
653938001964	catalytic residues [active]
653938001965	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
653938001966	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
653938001967	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
653938001968	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
653938001969	dimer interface [polypeptide binding]; other site
653938001970	motif 1; other site
653938001971	active site
653938001972	motif 2; other site
653938001973	motif 3; other site
653938001974	histidinol-phosphatase; Reviewed; Region: PRK08123
653938001975	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
653938001976	active site
653938001977	dimer interface [polypeptide binding]; other site
653938001978	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
653938001979	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
653938001980	DNA binding site [nucleotide binding]
653938001981	active site
653938001982	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
653938001983	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
653938001984	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
653938001985	beta-galactosidase; Region: BGL; TIGR03356
653938001986	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
653938001987	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938001988	DNA-binding site [nucleotide binding]; DNA binding site
653938001989	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
653938001990	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001991	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938001992	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
653938001993	Uncharacterized conserved protein [Function unknown]; Region: COG2966
653938001994	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
653938001995	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
653938001996	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
653938001997	Predicted esterase [General function prediction only]; Region: COG0400
653938001998	putative hydrolase; Provisional; Region: PRK11460
653938001999	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
653938002000	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
653938002001	putative RNA binding site [nucleotide binding]; other site
653938002002	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938002003	S-adenosylmethionine binding site [chemical binding]; other site
653938002004	invasion associated secreted endopeptidase; Provisional; Region: PRK13914
653938002005	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653938002006	Bacterial SH3 domain; Region: SH3_3; pfam08239
653938002007	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653938002008	NlpC/P60 family; Region: NLPC_P60; pfam00877
653938002009	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
653938002010	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
653938002011	ATP binding site [chemical binding]; other site
653938002012	putative Mg++ binding site [ion binding]; other site
653938002013	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
653938002014	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
653938002015	nucleotide binding region [chemical binding]; other site
653938002016	ATP-binding site [chemical binding]; other site
653938002017	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
653938002018	Domain of unknown function DUF20; Region: UPF0118; pfam01594
653938002019	WxL domain surface cell wall-binding; Region: WxL; pfam13731
653938002020	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
653938002021	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
653938002022	UreD urease accessory protein; Region: UreD; cl00530
653938002023	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
653938002024	DNA photolyase; Region: DNA_photolyase; pfam00875
653938002025	Predicted membrane protein [Function unknown]; Region: COG4852
653938002026	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
653938002027	DAK2 domain; Region: Dak2; pfam02734
653938002028	EDD domain protein, DegV family; Region: DegV; TIGR00762
653938002029	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
653938002030	Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752
653938002031	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
653938002032	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
653938002033	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
653938002034	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
653938002035	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
653938002036	homodimer interface [polypeptide binding]; other site
653938002037	substrate-cofactor binding pocket; other site
653938002038	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938002039	catalytic residue [active]
653938002040	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
653938002041	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938002042	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
653938002043	ligand binding site [chemical binding]; other site
653938002044	flexible hinge region; other site
653938002045	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
653938002046	BioY family; Region: BioY; pfam02632
653938002047	Predicted transcriptional regulators [Transcription]; Region: COG1695
653938002048	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
653938002049	Predicted membrane protein [Function unknown]; Region: COG4709
653938002050	Uncharacterized conserved protein [Function unknown]; Region: COG3595
653938002051	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
653938002052	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
653938002053	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
653938002054	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
653938002055	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
653938002056	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938002057	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
653938002058	Coenzyme A binding pocket [chemical binding]; other site
653938002059	Tic20-like protein; Region: Tic20; pfam09685
653938002060	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
653938002061	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
653938002062	Transcriptional regulators [Transcription]; Region: MarR; COG1846
653938002063	MarR family; Region: MarR_2; pfam12802
653938002064	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
653938002065	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653938002066	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938002067	Walker A/P-loop; other site
653938002068	ATP binding site [chemical binding]; other site
653938002069	Q-loop/lid; other site
653938002070	ABC transporter signature motif; other site
653938002071	Walker B; other site
653938002072	D-loop; other site
653938002073	H-loop/switch region; other site
653938002074	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
653938002075	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653938002076	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
653938002077	Walker A/P-loop; other site
653938002078	ATP binding site [chemical binding]; other site
653938002079	Q-loop/lid; other site
653938002080	ABC transporter signature motif; other site
653938002081	Walker B; other site
653938002082	D-loop; other site
653938002083	H-loop/switch region; other site
653938002084	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
653938002085	active site residue [active]
653938002086	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938002087	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938002088	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
653938002089	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
653938002090	Transcriptional regulators [Transcription]; Region: MarR; COG1846
653938002091	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
653938002092	putative DNA binding site [nucleotide binding]; other site
653938002093	putative Zn2+ binding site [ion binding]; other site
653938002094	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
653938002095	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
653938002096	putative NAD(P) binding site [chemical binding]; other site
653938002097	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
653938002098	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
653938002099	Coenzyme A binding pocket [chemical binding]; other site
653938002100	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
653938002101	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
653938002102	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
653938002103	putative active site [active]
653938002104	catalytic site [active]
653938002105	putative metal binding site [ion binding]; other site
653938002106	Catalytic domain of Protein Kinases; Region: PKc; cd00180
653938002107	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
653938002108	active site
653938002109	ATP binding site [chemical binding]; other site
653938002110	substrate binding site [chemical binding]; other site
653938002111	activation loop (A-loop); other site
653938002112	Eukaryotic protein of unknown function (DUF872); Region: DUF872; pfam05915
653938002113	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
653938002114	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
653938002115	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
653938002116	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
653938002117	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938002118	Coenzyme A binding pocket [chemical binding]; other site
653938002119	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
653938002120	active site
653938002121	catalytic triad [active]
653938002122	oxyanion hole [active]
653938002123	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
653938002124	domain interaction interfaces [polypeptide binding]; other site
653938002125	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
653938002126	domain interaction interfaces [polypeptide binding]; other site
653938002127	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
653938002128	domain interaction interfaces [polypeptide binding]; other site
653938002129	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
653938002130	domain interaction interfaces [polypeptide binding]; other site
653938002131	Isochorismatase family; Region: Isochorismatase; pfam00857
653938002132	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
653938002133	catalytic triad [active]
653938002134	conserved cis-peptide bond; other site
653938002135	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
653938002136	Mga helix-turn-helix domain; Region: Mga; pfam05043
653938002137	PRD domain; Region: PRD; pfam00874
653938002138	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
653938002139	active site
653938002140	P-loop; other site
653938002141	phosphorylation site [posttranslational modification]
653938002142	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
653938002143	active site
653938002144	phosphorylation site [posttranslational modification]
653938002145	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938002146	active site
653938002147	phosphorylation site [posttranslational modification]
653938002148	putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478
653938002149	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
653938002150	active site
653938002151	P-loop; other site
653938002152	phosphorylation site [posttranslational modification]
653938002153	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211
653938002154	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
653938002155	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938002156	motif II; other site
653938002157	Predicted transcriptional regulator [Transcription]; Region: COG1959
653938002158	Transcriptional regulator; Region: Rrf2; pfam02082
653938002159	Methyltransferase domain; Region: Methyltransf_31; pfam13847
653938002160	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938002161	S-adenosylmethionine binding site [chemical binding]; other site
653938002162	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
653938002163	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
653938002164	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
653938002165	Int/Topo IB signature motif; other site
653938002166	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
653938002167	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938002168	non-specific DNA binding site [nucleotide binding]; other site
653938002169	salt bridge; other site
653938002170	sequence-specific DNA binding site [nucleotide binding]; other site
653938002171	Domain of unknown function (DUF4121); Region: DUF4121; pfam13497
653938002172	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
653938002173	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938002174	non-specific DNA binding site [nucleotide binding]; other site
653938002175	salt bridge; other site
653938002176	sequence-specific DNA binding site [nucleotide binding]; other site
653938002177	Domain of unknown function (DUF771); Region: DUF771; pfam05595
653938002178	Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524
653938002179	Methyltransferase domain; Region: Methyltransf_25; pfam13649
653938002180	S-adenosylmethionine binding site [chemical binding]; other site
653938002181	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
653938002182	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
653938002183	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
653938002184	Int/Topo IB signature motif; other site
653938002185	Myb-like DNA-binding domain; Region: Myb_DNA-bind_6; pfam13921
653938002186	Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961
653938002187	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
653938002188	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
653938002189	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
653938002190	dimer interface [polypeptide binding]; other site
653938002191	ssDNA binding site [nucleotide binding]; other site
653938002192	tetramer (dimer of dimers) interface [polypeptide binding]; other site
653938002193	positive control sigma-like factor; Validated; Region: PRK06930
653938002194	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
653938002195	DNA binding residues [nucleotide binding]
653938002196	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
653938002197	active site
653938002198	DNA binding site [nucleotide binding]
653938002199	Int/Topo IB signature motif; other site
653938002200	Phage terminase, small subunit; Region: Terminase_4; pfam05119
653938002201	Phage Terminase; Region: Terminase_1; pfam03354
653938002202	Phage-related protein [Function unknown]; Region: COG4695; cl01923
653938002203	Phage portal protein; Region: Phage_portal; pfam04860
653938002204	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
653938002205	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
653938002206	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
653938002207	Phage capsid family; Region: Phage_capsid; pfam05065
653938002208	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
653938002209	oligomerization interface [polypeptide binding]; other site
653938002210	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
653938002211	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
653938002212	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
653938002213	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
653938002214	Phage tail protein; Region: Sipho_tail; cl17486
653938002215	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
653938002216	Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669
653938002217	Phage holin; Region: Phage_holin_5; pfam06946
653938002218	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
653938002219	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
653938002220	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
653938002221	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
653938002222	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
653938002223	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
653938002224	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
653938002225	active site
653938002226	catalytic tetrad [active]
653938002227	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
653938002228	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
653938002229	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938002230	motif II; other site
653938002231	Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176
653938002232	catalytic residue [active]
653938002233	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
653938002234	Sulfatase; Region: Sulfatase; pfam00884
653938002235	amino acid transporter; Region: 2A0306; TIGR00909
653938002236	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
653938002237	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
653938002238	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
653938002239	putative metal binding site [ion binding]; other site
653938002240	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
653938002241	active site
653938002242	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
653938002243	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
653938002244	Cl binding site [ion binding]; other site
653938002245	oligomer interface [polypeptide binding]; other site
653938002246	Transcriptional regulators [Transcription]; Region: GntR; COG1802
653938002247	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938002248	DNA-binding site [nucleotide binding]; DNA binding site
653938002249	Predicted membrane protein [Function unknown]; Region: COG1511
653938002250	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
653938002251	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
653938002252	linker region; other site
653938002253	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938002254	Transcriptional regulators [Transcription]; Region: FadR; COG2186
653938002255	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938002256	DNA-binding site [nucleotide binding]; DNA binding site
653938002257	FCD domain; Region: FCD; cl11656
653938002258	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
653938002259	Predicted integral membrane protein [Function unknown]; Region: COG5523
653938002260	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
653938002261	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
653938002262	active site
653938002263	metal binding site [ion binding]; metal-binding site
653938002264	Predicted membrane protein [Function unknown]; Region: COG2322
653938002265	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
653938002266	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
653938002267	minor groove reading motif; other site
653938002268	helix-hairpin-helix signature motif; other site
653938002269	substrate binding pocket [chemical binding]; other site
653938002270	active site
653938002271	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938002272	non-specific DNA binding site [nucleotide binding]; other site
653938002273	salt bridge; other site
653938002274	sequence-specific DNA binding site [nucleotide binding]; other site
653938002275	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
653938002276	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
653938002277	Helix-turn-helix domain; Region: HTH_28; pfam13518
653938002278	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
653938002279	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
653938002280	dimer interface [polypeptide binding]; other site
653938002281	substrate binding site [chemical binding]; other site
653938002282	ATP binding site [chemical binding]; other site
653938002283	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
653938002284	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938002285	active site
653938002286	motif I; other site
653938002287	motif II; other site
653938002288	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938002289	maltose O-acetyltransferase; Provisional; Region: PRK10092
653938002290	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
653938002291	active site
653938002292	substrate binding site [chemical binding]; other site
653938002293	trimer interface [polypeptide binding]; other site
653938002294	CoA binding site [chemical binding]; other site
653938002295	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
653938002296	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
653938002297	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
653938002298	Walker A/P-loop; other site
653938002299	ATP binding site [chemical binding]; other site
653938002300	Q-loop/lid; other site
653938002301	ABC transporter signature motif; other site
653938002302	Walker B; other site
653938002303	D-loop; other site
653938002304	H-loop/switch region; other site
653938002305	inner membrane transport permease; Provisional; Region: PRK15066
653938002306	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
653938002307	oxidoreductase; Provisional; Region: PRK07985
653938002308	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
653938002309	NAD(P) binding site [chemical binding]; other site
653938002310	active site
653938002311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
653938002312	Predicted membrane protein [Function unknown]; Region: COG3152
653938002313	DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181
653938002314	Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338
653938002315	Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987
653938002316	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
653938002317	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
653938002318	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
653938002319	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298
653938002320	FHIPEP family; Region: FHIPEP; pfam00771
653938002321	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726
653938002322	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
653938002323	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819
653938002324	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
653938002325	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
653938002326	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
653938002327	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
653938002328	Protein of unknown function (DUF3964); Region: DUF3964; pfam13107
653938002329	flagellar motor protein MotA; Validated; Region: PRK08124
653938002330	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
653938002331	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
653938002332	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
653938002333	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
653938002334	ligand binding site [chemical binding]; other site
653938002335	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
653938002336	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
653938002337	putative metal binding site; other site
653938002338	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653938002339	binding surface
653938002340	TPR motif; other site
653938002341	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
653938002342	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
653938002343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938002344	active site
653938002345	phosphorylation site [posttranslational modification]
653938002346	intermolecular recognition site; other site
653938002347	dimerization interface [polypeptide binding]; other site
653938002348	flagellin; Provisional; Region: PRK12805
653938002349	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
653938002350	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
653938002351	Response regulator receiver domain; Region: Response_reg; pfam00072
653938002352	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938002353	active site
653938002354	phosphorylation site [posttranslational modification]
653938002355	intermolecular recognition site; other site
653938002356	dimerization interface [polypeptide binding]; other site
653938002357	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
653938002358	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
653938002359	putative binding surface; other site
653938002360	active site
653938002361	P2 response regulator binding domain; Region: P2; pfam07194
653938002362	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
653938002363	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938002364	ATP binding site [chemical binding]; other site
653938002365	Mg2+ binding site [ion binding]; other site
653938002366	G-X-G motif; other site
653938002367	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
653938002368	flagellar motor switch protein; Validated; Region: PRK06788
653938002369	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
653938002370	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911
653938002371	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
653938002372	Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749
653938002373	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
653938002374	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
653938002375	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
653938002376	flagellar motor switch protein; Validated; Region: PRK06789
653938002377	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
653938002378	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
653938002379	flagellar motor switch protein; Reviewed; Region: PRK06782
653938002380	CheC-like family; Region: CheC; pfam04509
653938002381	CheC-like family; Region: CheC; pfam04509
653938002382	Chemotaxis phosphatase CheX; Region: CheX; cl15816
653938002383	CheC-like family; Region: CheC; pfam04509
653938002384	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
653938002385	Protein of unknown function (DUF327); Region: DUF327; pfam03885
653938002386	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799
653938002387	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
653938002388	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073
653938002389	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
653938002390	flagellar capping protein; Validated; Region: fliD; PRK06798
653938002391	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
653938002392	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
653938002393	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
653938002394	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797
653938002395	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
653938002396	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558
653938002397	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
653938002398	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699
653938002399	Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766
653938002400	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
653938002401	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
653938002402	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
653938002403	FliG C-terminal domain; Region: FliG_C; pfam01706
653938002404	flagellar assembly protein H; Validated; Region: fliH; PRK06800
653938002405	Flagellar assembly protein FliH; Region: FliH; pfam02108
653938002406	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793
653938002407	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
653938002408	Walker A motif; other site
653938002409	ATP binding site [chemical binding]; other site
653938002410	Walker B motif; other site
653938002411	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
653938002412	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
653938002413	N-acetyl-D-glucosamine binding site [chemical binding]; other site
653938002414	catalytic residue [active]
653938002415	Predicted transcriptional regulators [Transcription]; Region: COG1695
653938002416	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
653938002417	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
653938002418	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
653938002419	pyruvate oxidase; Provisional; Region: PRK08611
653938002420	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
653938002421	PYR/PP interface [polypeptide binding]; other site
653938002422	dimer interface [polypeptide binding]; other site
653938002423	tetramer interface [polypeptide binding]; other site
653938002424	TPP binding site [chemical binding]; other site
653938002425	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
653938002426	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
653938002427	TPP-binding site [chemical binding]; other site
653938002428	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
653938002429	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
653938002430	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653938002431	dimerization interface [polypeptide binding]; other site
653938002432	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653938002433	dimer interface [polypeptide binding]; other site
653938002434	putative CheW interface [polypeptide binding]; other site
653938002435	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
653938002436	putative active site [active]
653938002437	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
653938002438	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
653938002439	glutaminase active site [active]
653938002440	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
653938002441	dimer interface [polypeptide binding]; other site
653938002442	active site
653938002443	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
653938002444	dimer interface [polypeptide binding]; other site
653938002445	active site
653938002446	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
653938002447	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
653938002448	active site
653938002449	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
653938002450	GIY-YIG motif/motif A; other site
653938002451	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938002452	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938002453	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
653938002454	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
653938002455	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938002456	non-specific DNA binding site [nucleotide binding]; other site
653938002457	salt bridge; other site
653938002458	sequence-specific DNA binding site [nucleotide binding]; other site
653938002459	Transcriptional regulators [Transcription]; Region: PurR; COG1609
653938002460	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
653938002461	DNA binding site [nucleotide binding]
653938002462	domain linker motif; other site
653938002463	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
653938002464	ligand binding site [chemical binding]; other site
653938002465	dimerization interface [polypeptide binding]; other site
653938002466	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
653938002467	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
653938002468	substrate binding site [chemical binding]; other site
653938002469	hexamer interface [polypeptide binding]; other site
653938002470	metal binding site [ion binding]; metal-binding site
653938002471	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
653938002472	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
653938002473	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
653938002474	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
653938002475	active site turn [active]
653938002476	phosphorylation site [posttranslational modification]
653938002477	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
653938002478	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
653938002479	HPr interaction site; other site
653938002480	glycerol kinase (GK) interaction site [polypeptide binding]; other site
653938002481	active site
653938002482	phosphorylation site [posttranslational modification]
653938002483	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
653938002484	beta-galactosidase; Region: BGL; TIGR03356
653938002485	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938002486	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
653938002487	ligand binding site [chemical binding]; other site
653938002488	flexible hinge region; other site
653938002489	Predicted transcriptional regulators [Transcription]; Region: COG1725
653938002490	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938002491	DNA-binding site [nucleotide binding]; DNA binding site
653938002492	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
653938002493	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938002494	Walker A/P-loop; other site
653938002495	ATP binding site [chemical binding]; other site
653938002496	Q-loop/lid; other site
653938002497	ABC transporter signature motif; other site
653938002498	Walker B; other site
653938002499	D-loop; other site
653938002500	H-loop/switch region; other site
653938002501	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653938002502	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
653938002503	Walker A/P-loop; other site
653938002504	ATP binding site [chemical binding]; other site
653938002505	Q-loop/lid; other site
653938002506	ABC transporter signature motif; other site
653938002507	Walker B; other site
653938002508	D-loop; other site
653938002509	H-loop/switch region; other site
653938002510	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
653938002511	FtsX-like permease family; Region: FtsX; pfam02687
653938002512	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
653938002513	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938002514	non-specific DNA binding site [nucleotide binding]; other site
653938002515	salt bridge; other site
653938002516	sequence-specific DNA binding site [nucleotide binding]; other site
653938002517	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
653938002518	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938002519	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
653938002520	ligand binding site [chemical binding]; other site
653938002521	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
653938002522	non-specific DNA interactions [nucleotide binding]; other site
653938002523	DNA binding site [nucleotide binding]
653938002524	sequence specific DNA binding site [nucleotide binding]; other site
653938002525	putative cAMP binding site [chemical binding]; other site
653938002526	SnoaL-like domain; Region: SnoaL_4; pfam13577
653938002527	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
653938002528	active site
653938002529	catalytic triad [active]
653938002530	oxyanion hole [active]
653938002531	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938002532	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
653938002533	Walker A/P-loop; other site
653938002534	ATP binding site [chemical binding]; other site
653938002535	Q-loop/lid; other site
653938002536	ABC transporter signature motif; other site
653938002537	Walker B; other site
653938002538	D-loop; other site
653938002539	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
653938002540	H-loop/switch region; other site
653938002541	active site
653938002542	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
653938002543	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
653938002544	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
653938002545	Zn binding site [ion binding]; other site
653938002546	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
653938002547	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
653938002548	Zn binding site [ion binding]; other site
653938002549	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
653938002550	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
653938002551	Zn binding site [ion binding]; other site
653938002552	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
653938002553	Zn binding site [ion binding]; other site
653938002554	Predicted esterase [General function prediction only]; Region: COG0400
653938002555	putative hydrolase; Provisional; Region: PRK11460
653938002556	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
653938002557	GTPases [General function prediction only]; Region: HflX; COG2262
653938002558	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
653938002559	HflX GTPase family; Region: HflX; cd01878
653938002560	G1 box; other site
653938002561	GTP/Mg2+ binding site [chemical binding]; other site
653938002562	Switch I region; other site
653938002563	G2 box; other site
653938002564	G3 box; other site
653938002565	Switch II region; other site
653938002566	G4 box; other site
653938002567	G5 box; other site
653938002568	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
653938002569	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
653938002570	putative active site [active]
653938002571	putative metal binding site [ion binding]; other site
653938002572	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
653938002573	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
653938002574	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
653938002575	Uncharacterized conserved protein [Function unknown]; Region: COG3538
653938002576	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
653938002577	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
653938002578	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938002579	dimer interface [polypeptide binding]; other site
653938002580	conserved gate region; other site
653938002581	putative PBP binding loops; other site
653938002582	ABC-ATPase subunit interface; other site
653938002583	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
653938002584	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938002585	dimer interface [polypeptide binding]; other site
653938002586	conserved gate region; other site
653938002587	putative PBP binding loops; other site
653938002588	ABC-ATPase subunit interface; other site
653938002589	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
653938002590	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
653938002591	Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833
653938002592	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938002593	DNA-binding site [nucleotide binding]; DNA binding site
653938002594	Transcriptional regulators [Transcription]; Region: PurR; COG1609
653938002595	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
653938002596	ligand binding site [chemical binding]; other site
653938002597	dimerization interface [polypeptide binding]; other site
653938002598	Transcriptional regulators [Transcription]; Region: GntR; COG1802
653938002599	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938002600	DNA-binding site [nucleotide binding]; DNA binding site
653938002601	Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289
653938002602	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
653938002603	putative NADP binding site [chemical binding]; other site
653938002604	putative dimer interface [polypeptide binding]; other site
653938002605	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
653938002606	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
653938002607	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
653938002608	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
653938002609	nucleotide binding site [chemical binding]; other site
653938002610	Predicted membrane protein [Function unknown]; Region: COG4811
653938002611	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
653938002612	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
653938002613	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
653938002614	active site
653938002615	phosphorylation site [posttranslational modification]
653938002616	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
653938002617	active pocket/dimerization site; other site
653938002618	active site
653938002619	phosphorylation site [posttranslational modification]
653938002620	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
653938002621	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938002622	Walker A motif; other site
653938002623	ATP binding site [chemical binding]; other site
653938002624	Walker B motif; other site
653938002625	arginine finger; other site
653938002626	Transcriptional antiterminator [Transcription]; Region: COG3933
653938002627	PRD domain; Region: PRD; pfam00874
653938002628	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
653938002629	active pocket/dimerization site; other site
653938002630	active site
653938002631	phosphorylation site [posttranslational modification]
653938002632	PRD domain; Region: PRD; pfam00874
653938002633	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
653938002634	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
653938002635	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
653938002636	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
653938002637	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
653938002638	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
653938002639	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
653938002640	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
653938002641	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
653938002642	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
653938002643	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
653938002644	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
653938002645	putative deacylase active site [active]
653938002646	Predicted membrane protein [Function unknown]; Region: COG4640
653938002647	Protein of unknown function (DUF554); Region: DUF554; pfam04474
653938002648	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
653938002649	NADH(P)-binding; Region: NAD_binding_10; pfam13460
653938002650	NAD binding site [chemical binding]; other site
653938002651	substrate binding site [chemical binding]; other site
653938002652	putative active site [active]
653938002653	Predicted permeases [General function prediction only]; Region: RarD; COG2962
653938002654	EamA-like transporter family; Region: EamA; pfam00892
653938002655	Uncharacterized conserved protein [Function unknown]; Region: COG2353
653938002656	Transcriptional regulators [Transcription]; Region: MarR; COG1846
653938002657	MarR family; Region: MarR_2; pfam12802
653938002658	lysine transporter; Provisional; Region: PRK10836
653938002659	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653938002660	PAS domain; Region: PAS_9; pfam13426
653938002661	putative active site [active]
653938002662	heme pocket [chemical binding]; other site
653938002663	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
653938002664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
653938002665	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
653938002666	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
653938002667	synthetase active site [active]
653938002668	NTP binding site [chemical binding]; other site
653938002669	metal binding site [ion binding]; metal-binding site
653938002670	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
653938002671	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
653938002672	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
653938002673	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938002674	non-specific DNA binding site [nucleotide binding]; other site
653938002675	salt bridge; other site
653938002676	sequence-specific DNA binding site [nucleotide binding]; other site
653938002677	Cupin domain; Region: Cupin_2; pfam07883
653938002678	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
653938002679	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
653938002680	Walker A/P-loop; other site
653938002681	ATP binding site [chemical binding]; other site
653938002682	Q-loop/lid; other site
653938002683	ABC transporter signature motif; other site
653938002684	Walker B; other site
653938002685	D-loop; other site
653938002686	H-loop/switch region; other site
653938002687	TOBE domain; Region: TOBE_2; pfam08402
653938002688	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
653938002689	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938002690	putative PBP binding loops; other site
653938002691	ABC-ATPase subunit interface; other site
653938002692	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
653938002693	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938002694	dimer interface [polypeptide binding]; other site
653938002695	conserved gate region; other site
653938002696	putative PBP binding loops; other site
653938002697	ABC-ATPase subunit interface; other site
653938002698	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
653938002699	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
653938002700	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
653938002701	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
653938002702	active site
653938002703	zinc binding site [ion binding]; other site
653938002704	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
653938002705	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653938002706	Zn2+ binding site [ion binding]; other site
653938002707	Mg2+ binding site [ion binding]; other site
653938002708	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
653938002709	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
653938002710	nucleotide binding site [chemical binding]; other site
653938002711	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
653938002712	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
653938002713	FMN binding site [chemical binding]; other site
653938002714	substrate binding site [chemical binding]; other site
653938002715	putative catalytic residue [active]
653938002716	Transcriptional regulators [Transcription]; Region: MarR; COG1846
653938002717	MarR family; Region: MarR_2; pfam12802
653938002718	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
653938002719	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938002720	Coenzyme A binding pocket [chemical binding]; other site
653938002721	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
653938002722	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
653938002723	dimer interface [polypeptide binding]; other site
653938002724	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
653938002725	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
653938002726	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
653938002727	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
653938002728	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
653938002729	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938002730	motif II; other site
653938002731	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
653938002732	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
653938002733	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938002734	Coenzyme A binding pocket [chemical binding]; other site
653938002735	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
653938002736	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
653938002737	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
653938002738	DNA binding residues [nucleotide binding]
653938002739	putative dimer interface [polypeptide binding]; other site
653938002740	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
653938002741	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
653938002742	active site
653938002743	catalytic tetrad [active]
653938002744	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
653938002745	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
653938002746	homodimer interface [polypeptide binding]; other site
653938002747	catalytic residues [active]
653938002748	NAD binding site [chemical binding]; other site
653938002749	substrate binding pocket [chemical binding]; other site
653938002750	flexible flap; other site
653938002751	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
653938002752	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
653938002753	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
653938002754	PhoU domain; Region: PhoU; pfam01895
653938002755	PhoU domain; Region: PhoU; pfam01895
653938002756	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
653938002757	Integrase core domain; Region: rve; pfam00665
653938002758	Integrase core domain; Region: rve_3; cl15866
653938002759	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
653938002760	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
653938002761	dimer interface [polypeptide binding]; other site
653938002762	PYR/PP interface [polypeptide binding]; other site
653938002763	TPP binding site [chemical binding]; other site
653938002764	substrate binding site [chemical binding]; other site
653938002765	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
653938002766	Domain of unknown function; Region: EKR; smart00890
653938002767	4Fe-4S binding domain; Region: Fer4_6; pfam12837
653938002768	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
653938002769	TPP-binding site [chemical binding]; other site
653938002770	dimer interface [polypeptide binding]; other site
653938002771	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
653938002772	Predicted permeases [General function prediction only]; Region: COG0679
653938002773	Helix-turn-helix domain; Region: HTH_28; pfam13518
653938002774	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938002775	non-specific DNA binding site [nucleotide binding]; other site
653938002776	salt bridge; other site
653938002777	sequence-specific DNA binding site [nucleotide binding]; other site
653938002778	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
653938002779	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938002780	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938002781	Predicted membrane protein [Function unknown]; Region: COG3223
653938002782	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
653938002783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938002784	putative substrate translocation pore; other site
653938002785	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938002786	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938002787	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653938002788	putative substrate translocation pore; other site
653938002789	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
653938002790	MarR family; Region: MarR; pfam01047
653938002791	MarR family; Region: MarR_2; cl17246
653938002792	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
653938002793	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
653938002794	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
653938002795	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
653938002796	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938002797	motif II; other site
653938002798	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
653938002799	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
653938002800	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
653938002801	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
653938002802	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
653938002803	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
653938002804	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
653938002805	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
653938002806	Predicted membrane protein [Function unknown]; Region: COG3326
653938002807	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
653938002808	homotrimer interaction site [polypeptide binding]; other site
653938002809	putative active site [active]
653938002810	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
653938002811	substrate binding site [chemical binding]; other site
653938002812	zinc-binding site [ion binding]; other site
653938002813	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
653938002814	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
653938002815	GIY-YIG motif/motif A; other site
653938002816	active site
653938002817	catalytic site [active]
653938002818	putative DNA binding site [nucleotide binding]; other site
653938002819	metal binding site [ion binding]; metal-binding site
653938002820	UvrB/uvrC motif; Region: UVR; pfam02151
653938002821	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
653938002822	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
653938002823	substrate binding pocket [chemical binding]; other site
653938002824	membrane-bound complex binding site; other site
653938002825	hinge residues; other site
653938002826	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
653938002827	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938002828	dimer interface [polypeptide binding]; other site
653938002829	conserved gate region; other site
653938002830	putative PBP binding loops; other site
653938002831	ABC-ATPase subunit interface; other site
653938002832	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
653938002833	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
653938002834	Walker A/P-loop; other site
653938002835	ATP binding site [chemical binding]; other site
653938002836	Q-loop/lid; other site
653938002837	ABC transporter signature motif; other site
653938002838	Walker B; other site
653938002839	D-loop; other site
653938002840	H-loop/switch region; other site
653938002841	amidase; Provisional; Region: PRK11910
653938002842	Amidase; Region: Amidase; cl11426
653938002843	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
653938002844	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
653938002845	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
653938002846	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
653938002847	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
653938002848	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
653938002849	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
653938002850	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
653938002851	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
653938002852	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
653938002853	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
653938002854	Esterase/lipase [General function prediction only]; Region: COG1647
653938002855	Transcriptional regulators [Transcription]; Region: PurR; COG1609
653938002856	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
653938002857	DNA binding site [nucleotide binding]
653938002858	domain linker motif; other site
653938002859	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277
653938002860	putative dimerization interface [polypeptide binding]; other site
653938002861	putative ligand binding site [chemical binding]; other site
653938002862	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
653938002863	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
653938002864	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
653938002865	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938002866	dimer interface [polypeptide binding]; other site
653938002867	conserved gate region; other site
653938002868	putative PBP binding loops; other site
653938002869	ABC-ATPase subunit interface; other site
653938002870	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
653938002871	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938002872	dimer interface [polypeptide binding]; other site
653938002873	conserved gate region; other site
653938002874	ABC-ATPase subunit interface; other site
653938002875	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
653938002876	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
653938002877	Ca binding site [ion binding]; other site
653938002878	active site
653938002879	catalytic site [active]
653938002880	Protein of unknown function (DUF1861); Region: DUF1861; pfam08950
653938002881	Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152
653938002882	active site
653938002883	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
653938002884	active site
653938002885	substrate binding site [chemical binding]; other site
653938002886	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
653938002887	metal binding site [ion binding]; metal-binding site
653938002888	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
653938002889	DEAD-like helicases superfamily; Region: DEXDc; smart00487
653938002890	ATP binding site [chemical binding]; other site
653938002891	Mg++ binding site [ion binding]; other site
653938002892	motif III; other site
653938002893	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653938002894	nucleotide binding region [chemical binding]; other site
653938002895	ATP-binding site [chemical binding]; other site
653938002896	Predicted membrane protein [Function unknown]; Region: COG4708
653938002897	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
653938002898	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078
653938002899	Predicted transcriptional regulators [Transcription]; Region: COG1733
653938002900	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
653938002901	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
653938002902	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938002903	putative substrate translocation pore; other site
653938002904	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
653938002905	PRD domain; Region: PRD; pfam00874
653938002906	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
653938002907	active site
653938002908	P-loop; other site
653938002909	phosphorylation site [posttranslational modification]
653938002910	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938002911	active site
653938002912	phosphorylation site [posttranslational modification]
653938002913	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
653938002914	methionine cluster; other site
653938002915	active site
653938002916	phosphorylation site [posttranslational modification]
653938002917	metal binding site [ion binding]; metal-binding site
653938002918	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
653938002919	active site
653938002920	P-loop; other site
653938002921	phosphorylation site [posttranslational modification]
653938002922	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
653938002923	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
653938002924	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
653938002925	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
653938002926	active site
653938002927	trimer interface [polypeptide binding]; other site
653938002928	allosteric site; other site
653938002929	active site lid [active]
653938002930	hexamer (dimer of trimers) interface [polypeptide binding]; other site
653938002931	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
653938002932	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
653938002933	active site
653938002934	catalytic tetrad [active]
653938002935	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
653938002936	Collagen binding domain; Region: Collagen_bind; pfam05737
653938002937	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
653938002938	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653938002939	Uncharacterized conserved protein [Function unknown]; Region: COG3402
653938002940	Predicted membrane protein [Function unknown]; Region: COG3428
653938002941	Bacterial PH domain; Region: DUF304; pfam03703
653938002942	Bacterial PH domain; Region: DUF304; pfam03703
653938002943	Bacterial PH domain; Region: DUF304; pfam03703
653938002944	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
653938002945	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
653938002946	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
653938002947	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
653938002948	active site
653938002949	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
653938002950	dimer interface [polypeptide binding]; other site
653938002951	substrate binding site [chemical binding]; other site
653938002952	catalytic residues [active]
653938002953	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
653938002954	PemK-like protein; Region: PemK; pfam02452
653938002955	Rsbr N terminal; Region: Rsbr_N; pfam08678
653938002956	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
653938002957	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
653938002958	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
653938002959	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
653938002960	ATP binding site [chemical binding]; other site
653938002961	Mg2+ binding site [ion binding]; other site
653938002962	G-X-G motif; other site
653938002963	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
653938002964	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
653938002965	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
653938002966	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
653938002967	anti sigma factor interaction site; other site
653938002968	regulatory phosphorylation site [posttranslational modification]; other site
653938002969	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
653938002970	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938002971	ATP binding site [chemical binding]; other site
653938002972	Mg2+ binding site [ion binding]; other site
653938002973	G-X-G motif; other site
653938002974	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
653938002975	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
653938002976	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
653938002977	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
653938002978	DNA binding residues [nucleotide binding]
653938002979	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
653938002980	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
653938002981	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
653938002982	Sulfate transporter family; Region: Sulfate_transp; pfam00916
653938002983	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
653938002984	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
653938002985	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
653938002986	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
653938002987	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
653938002988	RNA binding site [nucleotide binding]; other site
653938002989	hypothetical protein; Provisional; Region: PRK04351
653938002990	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
653938002991	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
653938002992	Uncharacterized conserved protein [Function unknown]; Region: COG5646
653938002993	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
653938002994	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
653938002995	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
653938002996	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938002997	DNA-binding site [nucleotide binding]; DNA binding site
653938002998	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
653938002999	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
653938003000	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
653938003001	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
653938003002	glutathione reductase; Validated; Region: PRK06116
653938003003	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
653938003004	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653938003005	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
653938003006	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
653938003007	catalytic core [active]
653938003008	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
653938003009	Domain of unknown function DUF20; Region: UPF0118; pfam01594
653938003010	Predicted transcriptional regulators [Transcription]; Region: COG1725
653938003011	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938003012	DNA-binding site [nucleotide binding]; DNA binding site
653938003013	Predicted membrane protein [General function prediction only]; Region: COG4194
653938003014	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
653938003015	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
653938003016	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
653938003017	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
653938003018	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
653938003019	tetramerization interface [polypeptide binding]; other site
653938003020	NAD(P) binding site [chemical binding]; other site
653938003021	catalytic residues [active]
653938003022	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
653938003023	active site
653938003024	P-loop; other site
653938003025	phosphorylation site [posttranslational modification]
653938003026	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
653938003027	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
653938003028	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
653938003029	methionine cluster; other site
653938003030	active site
653938003031	phosphorylation site [posttranslational modification]
653938003032	metal binding site [ion binding]; metal-binding site
653938003033	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
653938003034	beta-galactosidase; Region: BGL; TIGR03356
653938003035	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
653938003036	Mga helix-turn-helix domain; Region: Mga; pfam05043
653938003037	PRD domain; Region: PRD; pfam00874
653938003038	PRD domain; Region: PRD; pfam00874
653938003039	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938003040	active site
653938003041	phosphorylation site [posttranslational modification]
653938003042	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653938003043	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
653938003044	ABC transporter; Region: ABC_tran_2; pfam12848
653938003045	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653938003046	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
653938003047	Predicted permeases [General function prediction only]; Region: COG0701
653938003048	Predicted membrane protein [Function unknown]; Region: COG3689
653938003049	pantothenate kinase; Provisional; Region: PRK05439
653938003050	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
653938003051	ATP-binding site [chemical binding]; other site
653938003052	CoA-binding site [chemical binding]; other site
653938003053	Mg2+-binding site [ion binding]; other site
653938003054	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
653938003055	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
653938003056	Walker A/P-loop; other site
653938003057	ATP binding site [chemical binding]; other site
653938003058	Q-loop/lid; other site
653938003059	ABC transporter signature motif; other site
653938003060	Walker B; other site
653938003061	D-loop; other site
653938003062	H-loop/switch region; other site
653938003063	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
653938003064	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
653938003065	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
653938003066	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
653938003067	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
653938003068	Domain of unknown function (DUF373); Region: DUF373; cl12079
653938003069	Sulfatase; Region: Sulfatase; pfam00884
653938003070	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
653938003071	active site
653938003072	DNA binding site [nucleotide binding]
653938003073	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
653938003074	active site
653938003075	catalytic site [active]
653938003076	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
653938003077	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
653938003078	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
653938003079	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
653938003080	Uncharacterized conserved protein [Function unknown]; Region: COG0398
653938003081	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
653938003082	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
653938003083	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
653938003084	Ligand binding site; other site
653938003085	Putative Catalytic site; other site
653938003086	DXD motif; other site
653938003087	epoxyqueuosine reductase; Region: TIGR00276
653938003088	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
653938003089	A new structural DNA glycosylase; Region: AlkD_like; cl11434
653938003090	active site
653938003091	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
653938003092	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
653938003093	dimer interface [polypeptide binding]; other site
653938003094	FMN binding site [chemical binding]; other site
653938003095	NADPH bind site [chemical binding]; other site
653938003096	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
653938003097	Low molecular weight phosphatase family; Region: LMWPc; cd00115
653938003098	active site
653938003099	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
653938003100	HSP90 family protein; Provisional; Region: PRK14083
653938003101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938003102	ATP binding site [chemical binding]; other site
653938003103	Mg2+ binding site [ion binding]; other site
653938003104	G-X-G motif; other site
653938003105	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
653938003106	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
653938003107	dimerization interface [polypeptide binding]; other site
653938003108	DPS ferroxidase diiron center [ion binding]; other site
653938003109	ion pore; other site
653938003110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
653938003111	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
653938003112	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
653938003113	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
653938003114	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
653938003115	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
653938003116	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
653938003117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938003118	putative substrate translocation pore; other site
653938003119	Transcriptional regulators [Transcription]; Region: FadR; COG2186
653938003120	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938003121	DNA-binding site [nucleotide binding]; DNA binding site
653938003122	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
653938003123	Domain of unknown function DUF20; Region: UPF0118; pfam01594
653938003124	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
653938003125	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
653938003126	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
653938003127	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
653938003128	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
653938003129	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
653938003130	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
653938003131	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
653938003132	active site
653938003133	dimer interface [polypeptide binding]; other site
653938003134	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
653938003135	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
653938003136	active site
653938003137	trimer interface [polypeptide binding]; other site
653938003138	allosteric site; other site
653938003139	active site lid [active]
653938003140	hexamer (dimer of trimers) interface [polypeptide binding]; other site
653938003141	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
653938003142	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938003143	DNA-binding site [nucleotide binding]; DNA binding site
653938003144	UTRA domain; Region: UTRA; pfam07702
653938003145	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
653938003146	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
653938003147	Mg++ binding site [ion binding]; other site
653938003148	putative catalytic motif [active]
653938003149	substrate binding site [chemical binding]; other site
653938003150	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
653938003151	Peptidase family U32; Region: Peptidase_U32; pfam01136
653938003152	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
653938003153	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
653938003154	Peptidase family U32; Region: Peptidase_U32; pfam01136
653938003155	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
653938003156	heat shock protein HtpX; Provisional; Region: PRK04897
653938003157	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
653938003158	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
653938003159	catalytic residues [active]
653938003160	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
653938003161	putative active site [active]
653938003162	putative metal binding residues [ion binding]; other site
653938003163	signature motif; other site
653938003164	putative triphosphate binding site [ion binding]; other site
653938003165	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653938003166	TPR motif; other site
653938003167	binding surface
653938003168	TPR repeat; Region: TPR_11; pfam13414
653938003169	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
653938003170	synthetase active site [active]
653938003171	NTP binding site [chemical binding]; other site
653938003172	metal binding site [ion binding]; metal-binding site
653938003173	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
653938003174	ATP-NAD kinase; Region: NAD_kinase; pfam01513
653938003175	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
653938003176	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
653938003177	active site
653938003178	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
653938003179	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
653938003180	NAD binding site [chemical binding]; other site
653938003181	homotetramer interface [polypeptide binding]; other site
653938003182	homodimer interface [polypeptide binding]; other site
653938003183	substrate binding site [chemical binding]; other site
653938003184	active site
653938003185	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
653938003186	DltD N-terminal region; Region: DltD_N; pfam04915
653938003187	DltD central region; Region: DltD_M; pfam04918
653938003188	DltD C-terminal region; Region: DltD_C; pfam04914
653938003189	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
653938003190	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
653938003191	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
653938003192	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
653938003193	acyl-activating enzyme (AAE) consensus motif; other site
653938003194	AMP binding site [chemical binding]; other site
653938003195	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
653938003196	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
653938003197	tetramer (dimer of dimers) interface [polypeptide binding]; other site
653938003198	active site
653938003199	dimer interface [polypeptide binding]; other site
653938003200	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938003201	Coenzyme A binding pocket [chemical binding]; other site
653938003202	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
653938003203	Putative esterase; Region: Esterase; pfam00756
653938003204	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
653938003205	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
653938003206	homodimer interface [polypeptide binding]; other site
653938003207	substrate-cofactor binding pocket; other site
653938003208	catalytic residue [active]
653938003209	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
653938003210	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938003211	Walker A/P-loop; other site
653938003212	ATP binding site [chemical binding]; other site
653938003213	Q-loop/lid; other site
653938003214	ABC transporter signature motif; other site
653938003215	Walker B; other site
653938003216	D-loop; other site
653938003217	H-loop/switch region; other site
653938003218	ABC-2 type transporter; Region: ABC2_membrane; cl17235
653938003219	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
653938003220	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938003221	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653938003222	putative substrate translocation pore; other site
653938003223	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
653938003224	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
653938003225	putative oligomer interface [polypeptide binding]; other site
653938003226	putative active site [active]
653938003227	metal binding site [ion binding]; metal-binding site
653938003228	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
653938003229	catalytic residues [active]
653938003230	dimer interface [polypeptide binding]; other site
653938003231	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
653938003232	LytTr DNA-binding domain; Region: LytTR; pfam04397
653938003233	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
653938003234	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938003235	Walker A/P-loop; other site
653938003236	ATP binding site [chemical binding]; other site
653938003237	Q-loop/lid; other site
653938003238	ABC transporter signature motif; other site
653938003239	Walker B; other site
653938003240	D-loop; other site
653938003241	H-loop/switch region; other site
653938003242	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
653938003243	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
653938003244	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
653938003245	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
653938003246	G1 box; other site
653938003247	putative GEF interaction site [polypeptide binding]; other site
653938003248	GTP/Mg2+ binding site [chemical binding]; other site
653938003249	Switch I region; other site
653938003250	G2 box; other site
653938003251	G3 box; other site
653938003252	Switch II region; other site
653938003253	G4 box; other site
653938003254	G5 box; other site
653938003255	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
653938003256	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
653938003257	MarR family; Region: MarR_2; cl17246
653938003258	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
653938003259	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
653938003260	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
653938003261	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
653938003262	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
653938003263	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
653938003264	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
653938003265	Acyltransferase family; Region: Acyl_transf_3; pfam01757
653938003266	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
653938003267	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
653938003268	DNA binding site [nucleotide binding]
653938003269	active site
653938003270	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938003271	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
653938003272	Walker A motif; other site
653938003273	ATP binding site [chemical binding]; other site
653938003274	Walker B motif; other site
653938003275	arginine finger; other site
653938003276	UvrB/uvrC motif; Region: UVR; pfam02151
653938003277	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938003278	Walker A motif; other site
653938003279	ATP binding site [chemical binding]; other site
653938003280	Walker B motif; other site
653938003281	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
653938003282	CAAX protease self-immunity; Region: Abi; pfam02517
653938003283	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
653938003284	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
653938003285	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873
653938003286	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
653938003287	dimerization domain swap beta strand [polypeptide binding]; other site
653938003288	regulatory protein interface [polypeptide binding]; other site
653938003289	active site
653938003290	regulatory phosphorylation site [posttranslational modification]; other site
653938003291	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
653938003292	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
653938003293	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
653938003294	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
653938003295	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
653938003296	Uncharacterized conserved protein [Function unknown]; Region: COG1434
653938003297	putative active site [active]
653938003298	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
653938003299	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
653938003300	aminotransferase A; Validated; Region: PRK07683
653938003301	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
653938003302	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938003303	homodimer interface [polypeptide binding]; other site
653938003304	catalytic residue [active]
653938003305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
653938003306	FOG: CBS domain [General function prediction only]; Region: COG0517
653938003307	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
653938003308	Transcriptional regulator [Transcription]; Region: LysR; COG0583
653938003309	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
653938003310	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
653938003311	dimerization interface [polypeptide binding]; other site
653938003312	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
653938003313	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
653938003314	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
653938003315	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
653938003316	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
653938003317	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
653938003318	metal binding site [ion binding]; metal-binding site
653938003319	putative dimer interface [polypeptide binding]; other site
653938003320	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
653938003321	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
653938003322	Mechanosensitive ion channel; Region: MS_channel; pfam00924
653938003323	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
653938003324	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938003325	Walker A/P-loop; other site
653938003326	ATP binding site [chemical binding]; other site
653938003327	Q-loop/lid; other site
653938003328	ABC transporter signature motif; other site
653938003329	Walker B; other site
653938003330	D-loop; other site
653938003331	H-loop/switch region; other site
653938003332	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
653938003333	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938003334	dimer interface [polypeptide binding]; other site
653938003335	conserved gate region; other site
653938003336	putative PBP binding loops; other site
653938003337	ABC-ATPase subunit interface; other site
653938003338	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
653938003339	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
653938003340	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
653938003341	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
653938003342	HPr interaction site; other site
653938003343	glycerol kinase (GK) interaction site [polypeptide binding]; other site
653938003344	active site
653938003345	phosphorylation site [posttranslational modification]
653938003346	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
653938003347	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
653938003348	S1 domain; Region: S1_2; pfam13509
653938003349	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
653938003350	RNA binding site [nucleotide binding]; other site
653938003351	Predicted membrane protein [Function unknown]; Region: COG4758
653938003352	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
653938003353	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
653938003354	Histidine kinase; Region: HisKA_3; pfam07730
653938003355	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938003356	ATP binding site [chemical binding]; other site
653938003357	Mg2+ binding site [ion binding]; other site
653938003358	G-X-G motif; other site
653938003359	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
653938003360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938003361	active site
653938003362	phosphorylation site [posttranslational modification]
653938003363	intermolecular recognition site; other site
653938003364	dimerization interface [polypeptide binding]; other site
653938003365	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
653938003366	DNA binding residues [nucleotide binding]
653938003367	dimerization interface [polypeptide binding]; other site
653938003368	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
653938003369	TrkA-N domain; Region: TrkA_N; pfam02254
653938003370	TrkA-C domain; Region: TrkA_C; pfam02080
653938003371	Predicted membrane protein [Function unknown]; Region: COG1289
653938003372	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
653938003373	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
653938003374	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
653938003375	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
653938003376	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
653938003377	hypothetical protein; Provisional; Region: PRK13667
653938003378	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
653938003379	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938003380	active site
653938003381	motif I; other site
653938003382	motif II; other site
653938003383	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938003384	Transcriptional regulators [Transcription]; Region: PurR; COG1609
653938003385	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
653938003386	DNA binding site [nucleotide binding]
653938003387	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
653938003388	ligand binding site [chemical binding]; other site
653938003389	dimerization interface [polypeptide binding]; other site
653938003390	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
653938003391	hexamer (dimer of trimers) interface [polypeptide binding]; other site
653938003392	trimer interface [polypeptide binding]; other site
653938003393	substrate binding site [chemical binding]; other site
653938003394	Mn binding site [ion binding]; other site
653938003395	transketolase; Reviewed; Region: PRK05899
653938003396	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
653938003397	TPP-binding site [chemical binding]; other site
653938003398	dimer interface [polypeptide binding]; other site
653938003399	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
653938003400	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
653938003401	PYR/PP interface [polypeptide binding]; other site
653938003402	dimer interface [polypeptide binding]; other site
653938003403	TPP binding site [chemical binding]; other site
653938003404	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
653938003405	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
653938003406	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
653938003407	nucleotide binding site [chemical binding]; other site
653938003408	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
653938003409	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
653938003410	active site turn [active]
653938003411	phosphorylation site [posttranslational modification]
653938003412	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
653938003413	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
653938003414	Uncharacterized integral membrane protein [Function unknown]; Region: COG3739
653938003415	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
653938003416	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
653938003417	GTP binding site; other site
653938003418	ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297
653938003419	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
653938003420	Walker A/P-loop; other site
653938003421	ATP binding site [chemical binding]; other site
653938003422	Q-loop/lid; other site
653938003423	ABC transporter signature motif; other site
653938003424	Walker B; other site
653938003425	D-loop; other site
653938003426	H-loop/switch region; other site
653938003427	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938003428	dimer interface [polypeptide binding]; other site
653938003429	conserved gate region; other site
653938003430	putative PBP binding loops; other site
653938003431	ABC-ATPase subunit interface; other site
653938003432	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
653938003433	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
653938003434	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
653938003435	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
653938003436	dimer interface [polypeptide binding]; other site
653938003437	putative functional site; other site
653938003438	putative MPT binding site; other site
653938003439	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
653938003440	Walker A motif; other site
653938003441	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
653938003442	MoaE homodimer interface [polypeptide binding]; other site
653938003443	MoaD interaction [polypeptide binding]; other site
653938003444	active site residues [active]
653938003445	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
653938003446	MoaE interaction surface [polypeptide binding]; other site
653938003447	MoeB interaction surface [polypeptide binding]; other site
653938003448	thiocarboxylated glycine; other site
653938003449	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
653938003450	trimer interface [polypeptide binding]; other site
653938003451	dimer interface [polypeptide binding]; other site
653938003452	putative active site [active]
653938003453	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
653938003454	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653938003455	FeS/SAM binding site; other site
653938003456	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
653938003457	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
653938003458	MPT binding site; other site
653938003459	trimer interface [polypeptide binding]; other site
653938003460	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
653938003461	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
653938003462	ATP binding site [chemical binding]; other site
653938003463	substrate interface [chemical binding]; other site
653938003464	Flavin Reductases; Region: FlaRed; cl00801
653938003465	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
653938003466	active site
653938003467	catalytic residues [active]
653938003468	metal binding site [ion binding]; metal-binding site
653938003469	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
653938003470	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
653938003471	TPP-binding site [chemical binding]; other site
653938003472	tetramer interface [polypeptide binding]; other site
653938003473	heterodimer interface [polypeptide binding]; other site
653938003474	phosphorylation loop region [posttranslational modification]
653938003475	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
653938003476	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
653938003477	alpha subunit interface [polypeptide binding]; other site
653938003478	TPP binding site [chemical binding]; other site
653938003479	heterodimer interface [polypeptide binding]; other site
653938003480	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
653938003481	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
653938003482	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
653938003483	E3 interaction surface; other site
653938003484	lipoyl attachment site [posttranslational modification]; other site
653938003485	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
653938003486	E3 interaction surface; other site
653938003487	lipoyl attachment site [posttranslational modification]; other site
653938003488	e3 binding domain; Region: E3_binding; pfam02817
653938003489	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
653938003490	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
653938003491	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
653938003492	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653938003493	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
653938003494	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
653938003495	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
653938003496	NAD(P) binding site [chemical binding]; other site
653938003497	LDH/MDH dimer interface [polypeptide binding]; other site
653938003498	substrate binding site [chemical binding]; other site
653938003499	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476
653938003500	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
653938003501	Thioredoxin; Region: Thioredoxin_4; pfam13462
653938003502	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
653938003503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938003504	active site
653938003505	phosphorylation site [posttranslational modification]
653938003506	intermolecular recognition site; other site
653938003507	dimerization interface [polypeptide binding]; other site
653938003508	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
653938003509	DNA binding site [nucleotide binding]
653938003510	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653938003511	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653938003512	dimerization interface [polypeptide binding]; other site
653938003513	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653938003514	dimer interface [polypeptide binding]; other site
653938003515	phosphorylation site [posttranslational modification]
653938003516	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938003517	ATP binding site [chemical binding]; other site
653938003518	Mg2+ binding site [ion binding]; other site
653938003519	G-X-G motif; other site
653938003520	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
653938003521	FtsX-like permease family; Region: FtsX; pfam02687
653938003522	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653938003523	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
653938003524	Walker A/P-loop; other site
653938003525	ATP binding site [chemical binding]; other site
653938003526	Q-loop/lid; other site
653938003527	ABC transporter signature motif; other site
653938003528	Walker B; other site
653938003529	D-loop; other site
653938003530	H-loop/switch region; other site
653938003531	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
653938003532	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
653938003533	Cl binding site [ion binding]; other site
653938003534	oligomer interface [polypeptide binding]; other site
653938003535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
653938003536	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
653938003537	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
653938003538	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
653938003539	active site
653938003540	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
653938003541	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
653938003542	G1 box; other site
653938003543	putative GEF interaction site [polypeptide binding]; other site
653938003544	GTP/Mg2+ binding site [chemical binding]; other site
653938003545	Switch I region; other site
653938003546	G2 box; other site
653938003547	G3 box; other site
653938003548	Switch II region; other site
653938003549	G4 box; other site
653938003550	G5 box; other site
653938003551	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
653938003552	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
653938003553	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896
653938003554	hypothetical protein; Provisional; Region: PRK13666
653938003555	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
653938003556	pyruvate carboxylase; Reviewed; Region: PRK12999
653938003557	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
653938003558	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
653938003559	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
653938003560	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
653938003561	active site
653938003562	catalytic residues [active]
653938003563	metal binding site [ion binding]; metal-binding site
653938003564	homodimer binding site [polypeptide binding]; other site
653938003565	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
653938003566	carboxyltransferase (CT) interaction site; other site
653938003567	biotinylation site [posttranslational modification]; other site
653938003568	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
653938003569	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
653938003570	putative binding site residues; other site
653938003571	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
653938003572	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
653938003573	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
653938003574	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
653938003575	Walker A/P-loop; other site
653938003576	ATP binding site [chemical binding]; other site
653938003577	Q-loop/lid; other site
653938003578	ABC transporter signature motif; other site
653938003579	Walker B; other site
653938003580	D-loop; other site
653938003581	H-loop/switch region; other site
653938003582	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
653938003583	SH3-like domain; Region: SH3_8; pfam13457
653938003584	SH3-like domain; Region: SH3_8; pfam13457
653938003585	SH3-like domain; Region: SH3_8; pfam13457
653938003586	SH3-like domain; Region: SH3_8; pfam13457
653938003587	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
653938003588	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
653938003589	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
653938003590	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
653938003591	active site
653938003592	tetramer interface; other site
653938003593	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
653938003594	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131
653938003595	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
653938003596	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
653938003597	active site
653938003598	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
653938003599	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
653938003600	substrate binding site; other site
653938003601	tetramer interface; other site
653938003602	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
653938003603	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
653938003604	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
653938003605	NAD binding site [chemical binding]; other site
653938003606	substrate binding site [chemical binding]; other site
653938003607	homodimer interface [polypeptide binding]; other site
653938003608	active site
653938003609	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
653938003610	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
653938003611	NADP binding site [chemical binding]; other site
653938003612	active site
653938003613	putative substrate binding site [chemical binding]; other site
653938003614	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
653938003615	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
653938003616	substrate binding site; other site
653938003617	dimer interface; other site
653938003618	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
653938003619	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
653938003620	putative NAD(P) binding site [chemical binding]; other site
653938003621	putative catalytic Zn binding site [ion binding]; other site
653938003622	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
653938003623	glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171
653938003624	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
653938003625	active site
653938003626	putative glycosyl transferase; Provisional; Region: PRK10073
653938003627	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
653938003628	active site
653938003629	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
653938003630	active site
653938003631	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
653938003632	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
653938003633	active site
653938003634	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
653938003635	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
653938003636	homodimer interface [polypeptide binding]; other site
653938003637	NAD binding pocket [chemical binding]; other site
653938003638	ATP binding pocket [chemical binding]; other site
653938003639	Mg binding site [ion binding]; other site
653938003640	active-site loop [active]
653938003641	Uncharacterized conserved protein [Function unknown]; Region: COG1359
653938003642	Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440
653938003643	active site
653938003644	P-loop; other site
653938003645	phosphorylation site [posttranslational modification]
653938003646	GMP synthase; Reviewed; Region: guaA; PRK00074
653938003647	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
653938003648	AMP/PPi binding site [chemical binding]; other site
653938003649	candidate oxyanion hole; other site
653938003650	catalytic triad [active]
653938003651	potential glutamine specificity residues [chemical binding]; other site
653938003652	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
653938003653	ATP Binding subdomain [chemical binding]; other site
653938003654	Dimerization subdomain; other site
653938003655	Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564
653938003656	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
653938003657	DNA methylase; Region: N6_N4_Mtase; pfam01555
653938003658	DNA methylase; Region: N6_N4_Mtase; pfam01555
653938003659	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653938003660	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421
653938003661	ATP binding site [chemical binding]; other site
653938003662	putative Mg++ binding site [ion binding]; other site
653938003663	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
653938003664	AIPR protein; Region: AIPR; pfam10592
653938003665	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938003666	non-specific DNA binding site [nucleotide binding]; other site
653938003667	salt bridge; other site
653938003668	sequence-specific DNA binding site [nucleotide binding]; other site
653938003669	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938003670	non-specific DNA binding site [nucleotide binding]; other site
653938003671	salt bridge; other site
653938003672	sequence-specific DNA binding site [nucleotide binding]; other site
653938003673	Protein of unknown function (DUF3130; Region: DUF3130; cl12867
653938003674	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
653938003675	LXG domain of WXG superfamily; Region: LXG; pfam04740
653938003676	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
653938003677	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
653938003678	MepB protein; Region: MepB; cl01985
653938003679	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
653938003680	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
653938003681	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
653938003682	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938003683	Coenzyme A binding pocket [chemical binding]; other site
653938003684	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
653938003685	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
653938003686	DNA binding residues [nucleotide binding]
653938003687	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
653938003688	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653938003689	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938003690	Walker A/P-loop; other site
653938003691	ATP binding site [chemical binding]; other site
653938003692	Q-loop/lid; other site
653938003693	ABC transporter signature motif; other site
653938003694	Walker B; other site
653938003695	D-loop; other site
653938003696	H-loop/switch region; other site
653938003697	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
653938003698	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653938003699	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938003700	Walker A/P-loop; other site
653938003701	ATP binding site [chemical binding]; other site
653938003702	Q-loop/lid; other site
653938003703	ABC transporter signature motif; other site
653938003704	Walker B; other site
653938003705	D-loop; other site
653938003706	H-loop/switch region; other site
653938003707	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
653938003708	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
653938003709	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
653938003710	DNA binding residues [nucleotide binding]
653938003711	putative dimer interface [polypeptide binding]; other site
653938003712	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
653938003713	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
653938003714	LRR adjacent; Region: LRR_adjacent; pfam08191
653938003715	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
653938003716	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
653938003717	Clp protease; Region: CLP_protease; pfam00574
653938003718	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
653938003719	oligomer interface [polypeptide binding]; other site
653938003720	active site residues [active]
653938003721	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
653938003722	dimer interface [polypeptide binding]; other site
653938003723	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
653938003724	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
653938003725	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
653938003726	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
653938003727	SLBB domain; Region: SLBB; pfam10531
653938003728	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
653938003729	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
653938003730	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
653938003731	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
653938003732	putative hexamer interface [polypeptide binding]; other site
653938003733	putative hexagonal pore; other site
653938003734	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
653938003735	putative hexamer interface [polypeptide binding]; other site
653938003736	putative hexagonal pore; other site
653938003737	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
653938003738	putative hexamer interface [polypeptide binding]; other site
653938003739	putative hexagonal pore; other site
653938003740	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
653938003741	G1 box; other site
653938003742	GTP/Mg2+ binding site [chemical binding]; other site
653938003743	G2 box; other site
653938003744	Switch I region; other site
653938003745	G3 box; other site
653938003746	Switch II region; other site
653938003747	G4 box; other site
653938003748	G5 box; other site
653938003749	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
653938003750	homotrimer interface [polypeptide binding]; other site
653938003751	Walker A motif; other site
653938003752	GTP binding site [chemical binding]; other site
653938003753	Walker B motif; other site
653938003754	Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368
653938003755	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
653938003756	catalytic core [active]
653938003757	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
653938003758	Sensory domain found in PocR; Region: PocR; pfam10114
653938003759	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
653938003760	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
653938003761	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
653938003762	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
653938003763	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
653938003764	Hexamer interface [polypeptide binding]; other site
653938003765	Hexagonal pore residue; other site
653938003766	propanediol utilization protein PduB; Provisional; Region: PRK15415
653938003767	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
653938003768	putative hexamer interface [polypeptide binding]; other site
653938003769	putative hexagonal pore; other site
653938003770	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
653938003771	putative hexamer interface [polypeptide binding]; other site
653938003772	putative hexagonal pore; other site
653938003773	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
653938003774	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
653938003775	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
653938003776	alpha-beta subunit interface [polypeptide binding]; other site
653938003777	alpha-gamma subunit interface [polypeptide binding]; other site
653938003778	active site
653938003779	substrate and K+ binding site; other site
653938003780	K+ binding site [ion binding]; other site
653938003781	cobalamin binding site [chemical binding]; other site
653938003782	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
653938003783	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
653938003784	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
653938003785	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
653938003786	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
653938003787	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
653938003788	putative hexamer interface [polypeptide binding]; other site
653938003789	putative hexagonal pore; other site
653938003790	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
653938003791	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
653938003792	Hexamer interface [polypeptide binding]; other site
653938003793	Hexagonal pore residue; other site
653938003794	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
653938003795	Propanediol utilisation protein PduL; Region: PduL; pfam06130
653938003796	Propanediol utilisation protein PduL; Region: PduL; pfam06130
653938003797	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
653938003798	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
653938003799	nucleotide binding site [chemical binding]; other site
653938003800	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
653938003801	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
653938003802	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
653938003803	Hexamer/Pentamer interface [polypeptide binding]; other site
653938003804	central pore; other site
653938003805	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
653938003806	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
653938003807	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
653938003808	putative catalytic cysteine [active]
653938003809	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
653938003810	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
653938003811	putative active site [active]
653938003812	metal binding site [ion binding]; metal-binding site
653938003813	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
653938003814	amphipathic channel; other site
653938003815	Asn-Pro-Ala signature motifs; other site
653938003816	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
653938003817	propionate/acetate kinase; Provisional; Region: PRK12379
653938003818	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
653938003819	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
653938003820	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938003821	homodimer interface [polypeptide binding]; other site
653938003822	catalytic residue [active]
653938003823	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
653938003824	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
653938003825	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
653938003826	putative active site [active]
653938003827	metal binding site [ion binding]; metal-binding site
653938003828	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
653938003829	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938003830	active site
653938003831	phosphorylation site [posttranslational modification]
653938003832	intermolecular recognition site; other site
653938003833	dimerization interface [polypeptide binding]; other site
653938003834	ANTAR domain; Region: ANTAR; pfam03861
653938003835	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
653938003836	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
653938003837	Histidine kinase; Region: HisKA_2; pfam07568
653938003838	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938003839	ATP binding site [chemical binding]; other site
653938003840	Mg2+ binding site [ion binding]; other site
653938003841	G-X-G motif; other site
653938003842	Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819
653938003843	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
653938003844	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
653938003845	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
653938003846	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
653938003847	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
653938003848	putative hexamer interface [polypeptide binding]; other site
653938003849	putative hexagonal pore; other site
653938003850	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
653938003851	putative hexamer interface [polypeptide binding]; other site
653938003852	putative hexagonal pore; other site
653938003853	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
653938003854	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
653938003855	Hexamer interface [polypeptide binding]; other site
653938003856	Hexagonal pore residue; other site
653938003857	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
653938003858	putative catalytic cysteine [active]
653938003859	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
653938003860	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
653938003861	Hexamer interface [polypeptide binding]; other site
653938003862	Putative hexagonal pore residue; other site
653938003863	Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812
653938003864	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
653938003865	Propanediol utilisation protein PduL; Region: PduL; pfam06130
653938003866	Propanediol utilisation protein PduL; Region: PduL; pfam06130
653938003867	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
653938003868	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
653938003869	Hexamer/Pentamer interface [polypeptide binding]; other site
653938003870	central pore; other site
653938003871	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
653938003872	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
653938003873	putative hexamer interface [polypeptide binding]; other site
653938003874	putative hexagonal pore; other site
653938003875	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
653938003876	putative hexamer interface [polypeptide binding]; other site
653938003877	putative hexagonal pore; other site
653938003878	Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346
653938003879	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
653938003880	Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249
653938003881	hypothetical protein; Region: PHA01818
653938003882	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
653938003883	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
653938003884	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
653938003885	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
653938003886	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
653938003887	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
653938003888	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
653938003889	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
653938003890	catalytic triad [active]
653938003891	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
653938003892	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
653938003893	Precorrin-8X methylmutase; Region: CbiC; pfam02570
653938003894	Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903
653938003895	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
653938003896	active site
653938003897	putative homodimer interface [polypeptide binding]; other site
653938003898	SAM binding site [chemical binding]; other site
653938003899	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
653938003900	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938003901	S-adenosylmethionine binding site [chemical binding]; other site
653938003902	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
653938003903	active site
653938003904	SAM binding site [chemical binding]; other site
653938003905	homodimer interface [polypeptide binding]; other site
653938003906	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
653938003907	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
653938003908	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
653938003909	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
653938003910	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
653938003911	active site
653938003912	SAM binding site [chemical binding]; other site
653938003913	homodimer interface [polypeptide binding]; other site
653938003914	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
653938003915	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
653938003916	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
653938003917	active site
653938003918	SAM binding site [chemical binding]; other site
653938003919	homodimer interface [polypeptide binding]; other site
653938003920	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
653938003921	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
653938003922	active site
653938003923	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
653938003924	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
653938003925	active site
653938003926	C-terminal domain interface [polypeptide binding]; other site
653938003927	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
653938003928	active site
653938003929	N-terminal domain interface [polypeptide binding]; other site
653938003930	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
653938003931	active site
653938003932	SAM binding site [chemical binding]; other site
653938003933	homodimer interface [polypeptide binding]; other site
653938003934	cobalt transport protein CbiM; Validated; Region: PRK08319
653938003935	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
653938003936	ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930
653938003937	cobalt transport protein CbiQ; Provisional; Region: PRK15485
653938003938	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
653938003939	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
653938003940	Walker A/P-loop; other site
653938003941	ATP binding site [chemical binding]; other site
653938003942	Q-loop/lid; other site
653938003943	ABC transporter signature motif; other site
653938003944	Walker B; other site
653938003945	D-loop; other site
653938003946	H-loop/switch region; other site
653938003947	cobyric acid synthase; Provisional; Region: PRK00784
653938003948	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
653938003949	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
653938003950	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
653938003951	catalytic triad [active]
653938003952	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
653938003953	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
653938003954	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
653938003955	AAA domain; Region: AAA_17; pfam13207
653938003956	Predicted transcriptional regulators [Transcription]; Region: COG1695
653938003957	Transcriptional regulator PadR-like family; Region: PadR; cl17335
653938003958	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
653938003959	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
653938003960	SH3-like domain; Region: SH3_8; pfam13457
653938003961	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
653938003962	SH3-like domain; Region: SH3_8; pfam13457
653938003963	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
653938003964	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
653938003965	oligomer interface [polypeptide binding]; other site
653938003966	active site
653938003967	metal binding site [ion binding]; metal-binding site
653938003968	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
653938003969	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
653938003970	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
653938003971	Predicted transcriptional regulators [Transcription]; Region: COG1733
653938003972	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
653938003973	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
653938003974	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
653938003975	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
653938003976	dimer interface [polypeptide binding]; other site
653938003977	motif 1; other site
653938003978	active site
653938003979	motif 2; other site
653938003980	motif 3; other site
653938003981	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
653938003982	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
653938003983	putative tRNA-binding site [nucleotide binding]; other site
653938003984	B3/4 domain; Region: B3_4; pfam03483
653938003985	tRNA synthetase B5 domain; Region: B5; smart00874
653938003986	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
653938003987	dimer interface [polypeptide binding]; other site
653938003988	motif 1; other site
653938003989	motif 3; other site
653938003990	motif 2; other site
653938003991	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
653938003992	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
653938003993	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653938003994	Walker A/P-loop; other site
653938003995	ATP binding site [chemical binding]; other site
653938003996	Q-loop/lid; other site
653938003997	ABC transporter signature motif; other site
653938003998	Walker B; other site
653938003999	D-loop; other site
653938004000	H-loop/switch region; other site
653938004001	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
653938004002	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
653938004003	FtsX-like permease family; Region: FtsX; pfam02687
653938004004	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
653938004005	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
653938004006	FtsX-like permease family; Region: FtsX; pfam02687
653938004007	Transcriptional regulators [Transcription]; Region: MarR; COG1846
653938004008	MarR family; Region: MarR_2; pfam12802
653938004009	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
653938004010	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
653938004011	ligand binding site [chemical binding]; other site
653938004012	active site
653938004013	UGI interface [polypeptide binding]; other site
653938004014	catalytic site [active]
653938004015	ribonuclease HIII; Provisional; Region: PRK00996
653938004016	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
653938004017	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
653938004018	RNA/DNA hybrid binding site [nucleotide binding]; other site
653938004019	active site
653938004020	Cell division protein ZapA; Region: ZapA; cl01146
653938004021	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
653938004022	Colicin V production protein; Region: Colicin_V; pfam02674
653938004023	hypothetical protein; Provisional; Region: PRK08609
653938004024	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
653938004025	active site
653938004026	primer binding site [nucleotide binding]; other site
653938004027	NTP  binding site [chemical binding]; other site
653938004028	metal binding triad [ion binding]; metal-binding site
653938004029	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
653938004030	active site
653938004031	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
653938004032	MutS domain III; Region: MutS_III; pfam05192
653938004033	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938004034	Walker A/P-loop; other site
653938004035	ATP binding site [chemical binding]; other site
653938004036	Q-loop/lid; other site
653938004037	ABC transporter signature motif; other site
653938004038	Walker B; other site
653938004039	D-loop; other site
653938004040	H-loop/switch region; other site
653938004041	Smr domain; Region: Smr; pfam01713
653938004042	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
653938004043	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
653938004044	catalytic residues [active]
653938004045	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
653938004046	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
653938004047	GIY-YIG motif/motif A; other site
653938004048	active site
653938004049	catalytic site [active]
653938004050	putative DNA binding site [nucleotide binding]; other site
653938004051	metal binding site [ion binding]; metal-binding site
653938004052	UvrB/uvrC motif; Region: UVR; pfam02151
653938004053	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
653938004054	aspartate kinase; Reviewed; Region: PRK06635
653938004055	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
653938004056	putative nucleotide binding site [chemical binding]; other site
653938004057	putative catalytic residues [active]
653938004058	putative Mg ion binding site [ion binding]; other site
653938004059	putative aspartate binding site [chemical binding]; other site
653938004060	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
653938004061	putative allosteric regulatory site; other site
653938004062	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
653938004063	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
653938004064	Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796
653938004065	ribonuclease PH; Reviewed; Region: rph; PRK00173
653938004066	Ribonuclease PH; Region: RNase_PH_bact; cd11362
653938004067	hexamer interface [polypeptide binding]; other site
653938004068	active site
653938004069	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
653938004070	active site
653938004071	dimerization interface [polypeptide binding]; other site
653938004072	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
653938004073	active site
653938004074	metal binding site [ion binding]; metal-binding site
653938004075	homotetramer interface [polypeptide binding]; other site
653938004076	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
653938004077	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
653938004078	Int/Topo IB signature motif; other site
653938004079	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
653938004080	Domain of unknown function (DUF955); Region: DUF955; pfam06114
653938004081	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
653938004082	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938004083	non-specific DNA binding site [nucleotide binding]; other site
653938004084	salt bridge; other site
653938004085	sequence-specific DNA binding site [nucleotide binding]; other site
653938004086	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
653938004087	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938004088	salt bridge; other site
653938004089	non-specific DNA binding site [nucleotide binding]; other site
653938004090	sequence-specific DNA binding site [nucleotide binding]; other site
653938004091	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
653938004092	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
653938004093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938004094	S-adenosylmethionine binding site [chemical binding]; other site
653938004095	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
653938004096	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
653938004097	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
653938004098	Int/Topo IB signature motif; other site
653938004099	Myb-like DNA-binding domain; Region: Myb_DNA-bind_6; pfam13921
653938004100	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
653938004101	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
653938004102	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
653938004103	AAA domain; Region: AAA_24; pfam13479
653938004104	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653938004105	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
653938004106	putative Mg++ binding site [ion binding]; other site
653938004107	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653938004108	nucleotide binding region [chemical binding]; other site
653938004109	ATP-binding site [chemical binding]; other site
653938004110	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
653938004111	Protein of unknown function (DUF669); Region: DUF669; pfam05037
653938004112	Uncharacterized conserved protein [Function unknown]; Region: COG4983
653938004113	D5 N terminal like; Region: D5_N; pfam08706
653938004114	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
653938004115	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
653938004116	VRR-NUC domain; Region: VRR_NUC; pfam08774
653938004117	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
653938004118	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
653938004119	Protein of unknown function (DUF722); Region: DUF722; pfam05263
653938004120	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
653938004121	putative active site [active]
653938004122	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
653938004123	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
653938004124	active site
653938004125	Phage terminase, small subunit; Region: Terminase_4; cl01525
653938004126	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
653938004127	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
653938004128	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
653938004129	Phage portal protein; Region: Phage_portal; pfam04860
653938004130	Phage-related protein [Function unknown]; Region: COG4695; cl01923
653938004131	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
653938004132	oligomer interface [polypeptide binding]; other site
653938004133	active site residues [active]
653938004134	Phage capsid family; Region: Phage_capsid; pfam05065
653938004135	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
653938004136	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
653938004137	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
653938004138	N-acetyl-D-glucosamine binding site [chemical binding]; other site
653938004139	catalytic residue [active]
653938004140	Phage tail protein; Region: Sipho_tail; cl17486
653938004141	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
653938004142	Bacteriophage holin; Region: Phage_holin_1; pfam04531
653938004143	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
653938004144	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
653938004145	Uncharacterized conserved protein [Function unknown]; Region: COG5361
653938004146	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
653938004147	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
653938004148	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
653938004149	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
653938004150	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
653938004151	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
653938004152	dimer interface [polypeptide binding]; other site
653938004153	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
653938004154	catalytic core [active]
653938004155	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
653938004156	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
653938004157	ATP binding site [chemical binding]; other site
653938004158	Mg++ binding site [ion binding]; other site
653938004159	motif III; other site
653938004160	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653938004161	nucleotide binding region [chemical binding]; other site
653938004162	ATP-binding site [chemical binding]; other site
653938004163	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
653938004164	RNA binding site [nucleotide binding]; other site
653938004165	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
653938004166	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
653938004167	putative active site [active]
653938004168	nucleotide binding site [chemical binding]; other site
653938004169	nudix motif; other site
653938004170	putative metal binding site [ion binding]; other site
653938004171	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938004172	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653938004173	putative substrate translocation pore; other site
653938004174	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938004175	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
653938004176	ligand binding site [chemical binding]; other site
653938004177	flexible hinge region; other site
653938004178	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
653938004179	Uncharacterized conserved protein [Function unknown]; Region: COG1284
653938004180	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
653938004181	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
653938004182	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
653938004183	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938004184	DNA-binding site [nucleotide binding]; DNA binding site
653938004185	UTRA domain; Region: UTRA; pfam07702
653938004186	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
653938004187	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
653938004188	Ca binding site [ion binding]; other site
653938004189	active site
653938004190	catalytic site [active]
653938004191	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
653938004192	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
653938004193	active site turn [active]
653938004194	phosphorylation site [posttranslational modification]
653938004195	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
653938004196	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
653938004197	nudix motif; other site
653938004198	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
653938004199	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
653938004200	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
653938004201	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
653938004202	putative catalytic cysteine [active]
653938004203	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
653938004204	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
653938004205	nucleotide binding site [chemical binding]; other site
653938004206	homotetrameric interface [polypeptide binding]; other site
653938004207	putative phosphate binding site [ion binding]; other site
653938004208	putative allosteric binding site; other site
653938004209	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
653938004210	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
653938004211	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
653938004212	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938004213	non-specific DNA binding site [nucleotide binding]; other site
653938004214	salt bridge; other site
653938004215	sequence-specific DNA binding site [nucleotide binding]; other site
653938004216	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938004217	non-specific DNA binding site [nucleotide binding]; other site
653938004218	salt bridge; other site
653938004219	sequence-specific DNA binding site [nucleotide binding]; other site
653938004220	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
653938004221	active site
653938004222	trigger factor; Provisional; Region: tig; PRK01490
653938004223	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
653938004224	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
653938004225	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
653938004226	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
653938004227	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938004228	Walker A motif; other site
653938004229	ATP binding site [chemical binding]; other site
653938004230	Walker B motif; other site
653938004231	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
653938004232	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
653938004233	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
653938004234	Catalytic site [active]
653938004235	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
653938004236	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
653938004237	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
653938004238	Catalytic site [active]
653938004239	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
653938004240	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
653938004241	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
653938004242	Catalytic site [active]
653938004243	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
653938004244	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
653938004245	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
653938004246	GTP/Mg2+ binding site [chemical binding]; other site
653938004247	G4 box; other site
653938004248	G5 box; other site
653938004249	G1 box; other site
653938004250	Switch I region; other site
653938004251	G2 box; other site
653938004252	G3 box; other site
653938004253	Switch II region; other site
653938004254	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
653938004255	RNA/DNA hybrid binding site [nucleotide binding]; other site
653938004256	active site
653938004257	DNA protecting protein DprA; Region: dprA; TIGR00732
653938004258	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
653938004259	DNA topoisomerase I; Validated; Region: PRK05582
653938004260	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
653938004261	active site
653938004262	interdomain interaction site; other site
653938004263	putative metal-binding site [ion binding]; other site
653938004264	nucleotide binding site [chemical binding]; other site
653938004265	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
653938004266	domain I; other site
653938004267	DNA binding groove [nucleotide binding]
653938004268	phosphate binding site [ion binding]; other site
653938004269	domain II; other site
653938004270	domain III; other site
653938004271	nucleotide binding site [chemical binding]; other site
653938004272	catalytic site [active]
653938004273	domain IV; other site
653938004274	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
653938004275	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
653938004276	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
653938004277	Glucose inhibited division protein A; Region: GIDA; pfam01134
653938004278	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
653938004279	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
653938004280	active site
653938004281	DNA binding site [nucleotide binding]
653938004282	Int/Topo IB signature motif; other site
653938004283	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
653938004284	active site
653938004285	HslU subunit interaction site [polypeptide binding]; other site
653938004286	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
653938004287	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938004288	Walker A motif; other site
653938004289	ATP binding site [chemical binding]; other site
653938004290	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
653938004291	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
653938004292	transcriptional repressor CodY; Validated; Region: PRK04158
653938004293	CodY GAF-like domain; Region: CodY; pfam06018
653938004294	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
653938004295	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
653938004296	active site
653938004297	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
653938004298	active site
653938004299	catalytic residues [active]
653938004300	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
653938004301	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
653938004302	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
653938004303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938004304	Mg2+ binding site [ion binding]; other site
653938004305	G-X-G motif; other site
653938004306	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
653938004307	anchoring element; other site
653938004308	dimer interface [polypeptide binding]; other site
653938004309	ATP binding site [chemical binding]; other site
653938004310	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
653938004311	active site
653938004312	putative metal-binding site [ion binding]; other site
653938004313	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
653938004314	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
653938004315	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
653938004316	CAP-like domain; other site
653938004317	active site
653938004318	primary dimer interface [polypeptide binding]; other site
653938004319	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
653938004320	S-ribosylhomocysteinase; Provisional; Region: PRK02260
653938004321	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938004322	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938004323	putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641
653938004324	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
653938004325	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
653938004326	catalytic triad [active]
653938004327	catalytic triad [active]
653938004328	oxyanion hole [active]
653938004329	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
653938004330	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
653938004331	active site
653938004332	catalytic site [active]
653938004333	metal binding site [ion binding]; metal-binding site
653938004334	dimer interface [polypeptide binding]; other site
653938004335	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
653938004336	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
653938004337	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
653938004338	bacterial Hfq-like; Region: Hfq; cd01716
653938004339	hexamer interface [polypeptide binding]; other site
653938004340	Sm1 motif; other site
653938004341	RNA binding site [nucleotide binding]; other site
653938004342	Sm2 motif; other site
653938004343	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
653938004344	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
653938004345	HflX GTPase family; Region: HflX; cd01878
653938004346	G1 box; other site
653938004347	GTP/Mg2+ binding site [chemical binding]; other site
653938004348	Switch I region; other site
653938004349	G2 box; other site
653938004350	G3 box; other site
653938004351	Switch II region; other site
653938004352	G4 box; other site
653938004353	G5 box; other site
653938004354	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
653938004355	Aluminium resistance protein; Region: Alum_res; pfam06838
653938004356	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
653938004357	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
653938004358	DNA binding residues [nucleotide binding]
653938004359	putative dimer interface [polypeptide binding]; other site
653938004360	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
653938004361	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
653938004362	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
653938004363	arsenical pump membrane protein; Provisional; Region: PRK15445
653938004364	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
653938004365	transmembrane helices; other site
653938004366	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
653938004367	LexA repressor; Validated; Region: PRK00215
653938004368	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
653938004369	putative DNA binding site [nucleotide binding]; other site
653938004370	putative Zn2+ binding site [ion binding]; other site
653938004371	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
653938004372	Catalytic site [active]
653938004373	cell division suppressor protein YneA; Provisional; Region: PRK14125
653938004374	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
653938004375	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
653938004376	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
653938004377	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
653938004378	TPP-binding site [chemical binding]; other site
653938004379	dimer interface [polypeptide binding]; other site
653938004380	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
653938004381	PYR/PP interface [polypeptide binding]; other site
653938004382	dimer interface [polypeptide binding]; other site
653938004383	TPP binding site [chemical binding]; other site
653938004384	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
653938004385	hypothetical protein; Provisional; Region: PRK01844
653938004386	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
653938004387	Protein of unknown function (DUF970); Region: DUF970; cl17525
653938004388	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
653938004389	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
653938004390	ParB-like nuclease domain; Region: ParBc; pfam02195
653938004391	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
653938004392	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
653938004393	Active Sites [active]
653938004394	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
653938004395	DEAD-like helicases superfamily; Region: DEXDc; smart00487
653938004396	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
653938004397	ATP binding site [chemical binding]; other site
653938004398	putative Mg++ binding site [ion binding]; other site
653938004399	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
653938004400	putative nucleotide binding site [chemical binding]; other site
653938004401	uridine monophosphate binding site [chemical binding]; other site
653938004402	homohexameric interface [polypeptide binding]; other site
653938004403	ribosome recycling factor; Reviewed; Region: frr; PRK00083
653938004404	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
653938004405	hinge region; other site
653938004406	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830
653938004407	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
653938004408	catalytic residue [active]
653938004409	putative FPP diphosphate  binding site; other site
653938004410	putative FPP binding hydrophobic cleft; other site
653938004411	dimer interface [polypeptide binding]; other site
653938004412	putative IPP diphosphate binding site; other site
653938004413	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
653938004414	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
653938004415	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
653938004416	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
653938004417	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
653938004418	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
653938004419	RIP metalloprotease RseP; Region: TIGR00054
653938004420	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
653938004421	active site
653938004422	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
653938004423	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
653938004424	protein binding site [polypeptide binding]; other site
653938004425	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
653938004426	putative substrate binding region [chemical binding]; other site
653938004427	prolyl-tRNA synthetase; Provisional; Region: PRK09194
653938004428	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
653938004429	dimer interface [polypeptide binding]; other site
653938004430	motif 1; other site
653938004431	active site
653938004432	motif 2; other site
653938004433	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
653938004434	putative deacylase active site [active]
653938004435	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
653938004436	active site
653938004437	motif 3; other site
653938004438	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
653938004439	anticodon binding site; other site
653938004440	DNA polymerase III PolC; Validated; Region: polC; PRK00448
653938004441	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
653938004442	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
653938004443	generic binding surface II; other site
653938004444	generic binding surface I; other site
653938004445	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
653938004446	active site
653938004447	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
653938004448	active site
653938004449	catalytic site [active]
653938004450	substrate binding site [chemical binding]; other site
653938004451	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
653938004452	ribosome maturation protein RimP; Reviewed; Region: PRK00092
653938004453	Sm and related proteins; Region: Sm_like; cl00259
653938004454	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
653938004455	putative oligomer interface [polypeptide binding]; other site
653938004456	putative RNA binding site [nucleotide binding]; other site
653938004457	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
653938004458	NusA N-terminal domain; Region: NusA_N; pfam08529
653938004459	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
653938004460	RNA binding site [nucleotide binding]; other site
653938004461	homodimer interface [polypeptide binding]; other site
653938004462	NusA-like KH domain; Region: KH_5; pfam13184
653938004463	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
653938004464	G-X-X-G motif; other site
653938004465	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
653938004466	putative RNA binding cleft [nucleotide binding]; other site
653938004467	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
653938004468	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
653938004469	translation initiation factor IF-2; Region: IF-2; TIGR00487
653938004470	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
653938004471	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
653938004472	G1 box; other site
653938004473	putative GEF interaction site [polypeptide binding]; other site
653938004474	GTP/Mg2+ binding site [chemical binding]; other site
653938004475	Switch I region; other site
653938004476	G2 box; other site
653938004477	G3 box; other site
653938004478	Switch II region; other site
653938004479	G4 box; other site
653938004480	G5 box; other site
653938004481	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
653938004482	Translation-initiation factor 2; Region: IF-2; pfam11987
653938004483	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
653938004484	Protein of unknown function (DUF503); Region: DUF503; cl00669
653938004485	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
653938004486	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
653938004487	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
653938004488	RNA binding site [nucleotide binding]; other site
653938004489	active site
653938004490	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
653938004491	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
653938004492	active site
653938004493	Riboflavin kinase; Region: Flavokinase; smart00904
653938004494	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
653938004495	16S/18S rRNA binding site [nucleotide binding]; other site
653938004496	S13e-L30e interaction site [polypeptide binding]; other site
653938004497	25S rRNA binding site [nucleotide binding]; other site
653938004498	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
653938004499	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
653938004500	RNase E interface [polypeptide binding]; other site
653938004501	trimer interface [polypeptide binding]; other site
653938004502	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
653938004503	RNase E interface [polypeptide binding]; other site
653938004504	trimer interface [polypeptide binding]; other site
653938004505	active site
653938004506	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
653938004507	putative nucleic acid binding region [nucleotide binding]; other site
653938004508	G-X-X-G motif; other site
653938004509	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
653938004510	RNA binding site [nucleotide binding]; other site
653938004511	domain interface; other site
653938004512	GTPase RsgA; Reviewed; Region: PRK01889
653938004513	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
653938004514	RNA binding site [nucleotide binding]; other site
653938004515	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
653938004516	GTPase/Zn-binding domain interface [polypeptide binding]; other site
653938004517	GTP/Mg2+ binding site [chemical binding]; other site
653938004518	G4 box; other site
653938004519	G5 box; other site
653938004520	G1 box; other site
653938004521	Switch I region; other site
653938004522	G2 box; other site
653938004523	G3 box; other site
653938004524	Switch II region; other site
653938004525	YceG-like family; Region: YceG; pfam02618
653938004526	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
653938004527	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
653938004528	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
653938004529	Rhomboid family; Region: Rhomboid; pfam01694
653938004530	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653938004531	TPR motif; other site
653938004532	TPR repeat; Region: TPR_11; pfam13414
653938004533	binding surface
653938004534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
653938004535	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
653938004536	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
653938004537	nucleotide binding site [chemical binding]; other site
653938004538	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
653938004539	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
653938004540	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
653938004541	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
653938004542	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
653938004543	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
653938004544	Type II/IV secretion system protein; Region: T2SE; pfam00437
653938004545	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
653938004546	Walker A motif; other site
653938004547	ATP binding site [chemical binding]; other site
653938004548	Walker B motif; other site
653938004549	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
653938004550	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
653938004551	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
653938004552	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
653938004553	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
653938004554	tetramer interface [polypeptide binding]; other site
653938004555	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938004556	catalytic residue [active]
653938004557	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
653938004558	tetramer interface [polypeptide binding]; other site
653938004559	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938004560	catalytic residue [active]
653938004561	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
653938004562	active site residue [active]
653938004563	Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872
653938004564	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
653938004565	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
653938004566	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
653938004567	active site
653938004568	elongation factor P; Validated; Region: PRK00529
653938004569	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
653938004570	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
653938004571	RNA binding site [nucleotide binding]; other site
653938004572	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
653938004573	RNA binding site [nucleotide binding]; other site
653938004574	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
653938004575	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
653938004576	carboxyltransferase (CT) interaction site; other site
653938004577	biotinylation site [posttranslational modification]; other site
653938004578	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
653938004579	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
653938004580	ATP-grasp domain; Region: ATP-grasp_4; cl17255
653938004581	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
653938004582	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
653938004583	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
653938004584	putative RNA binding site [nucleotide binding]; other site
653938004585	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170
653938004586	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
653938004587	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
653938004588	homodimer interface [polypeptide binding]; other site
653938004589	NADP binding site [chemical binding]; other site
653938004590	substrate binding site [chemical binding]; other site
653938004591	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
653938004592	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
653938004593	generic binding surface II; other site
653938004594	generic binding surface I; other site
653938004595	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064
653938004596	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
653938004597	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
653938004598	substrate binding pocket [chemical binding]; other site
653938004599	chain length determination region; other site
653938004600	substrate-Mg2+ binding site; other site
653938004601	catalytic residues [active]
653938004602	aspartate-rich region 1; other site
653938004603	active site lid residues [active]
653938004604	aspartate-rich region 2; other site
653938004605	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
653938004606	DNA-binding site [nucleotide binding]; DNA binding site
653938004607	RNA-binding motif; other site
653938004608	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
653938004609	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
653938004610	TPP-binding site; other site
653938004611	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
653938004612	PYR/PP interface [polypeptide binding]; other site
653938004613	dimer interface [polypeptide binding]; other site
653938004614	TPP binding site [chemical binding]; other site
653938004615	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
653938004616	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
653938004617	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
653938004618	RNA binding surface [nucleotide binding]; other site
653938004619	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
653938004620	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
653938004621	arginine repressor; Provisional; Region: PRK04280
653938004622	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
653938004623	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
653938004624	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
653938004625	Walker A/P-loop; other site
653938004626	ATP binding site [chemical binding]; other site
653938004627	Q-loop/lid; other site
653938004628	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
653938004629	ABC transporter signature motif; other site
653938004630	Walker B; other site
653938004631	D-loop; other site
653938004632	H-loop/switch region; other site
653938004633	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
653938004634	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
653938004635	nucleotide binding site [chemical binding]; other site
653938004636	Acetokinase family; Region: Acetate_kinase; cl17229
653938004637	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
653938004638	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653938004639	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
653938004640	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
653938004641	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
653938004642	tetramer interface [polypeptide binding]; other site
653938004643	TPP-binding site [chemical binding]; other site
653938004644	heterodimer interface [polypeptide binding]; other site
653938004645	phosphorylation loop region [posttranslational modification]
653938004646	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
653938004647	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
653938004648	alpha subunit interface [polypeptide binding]; other site
653938004649	TPP binding site [chemical binding]; other site
653938004650	heterodimer interface [polypeptide binding]; other site
653938004651	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
653938004652	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
653938004653	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
653938004654	E3 interaction surface; other site
653938004655	lipoyl attachment site [posttranslational modification]; other site
653938004656	e3 binding domain; Region: E3_binding; pfam02817
653938004657	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
653938004658	peptidase T-like protein; Region: PepT-like; TIGR01883
653938004659	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
653938004660	metal binding site [ion binding]; metal-binding site
653938004661	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
653938004662	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
653938004663	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
653938004664	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
653938004665	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938004666	active site
653938004667	phosphorylation site [posttranslational modification]
653938004668	intermolecular recognition site; other site
653938004669	dimerization interface [polypeptide binding]; other site
653938004670	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
653938004671	DNA binding site [nucleotide binding]
653938004672	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653938004673	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653938004674	dimerization interface [polypeptide binding]; other site
653938004675	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653938004676	dimer interface [polypeptide binding]; other site
653938004677	phosphorylation site [posttranslational modification]
653938004678	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938004679	ATP binding site [chemical binding]; other site
653938004680	Mg2+ binding site [ion binding]; other site
653938004681	G-X-G motif; other site
653938004682	OxaA-like protein precursor; Validated; Region: PRK01622
653938004683	acylphosphatase; Provisional; Region: PRK14443
653938004684	Protein of unknown function (DUF1033); Region: DUF1033; cl11549
653938004685	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
653938004686	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
653938004687	homotetramer interface [polypeptide binding]; other site
653938004688	FMN binding site [chemical binding]; other site
653938004689	homodimer contacts [polypeptide binding]; other site
653938004690	putative active site [active]
653938004691	putative substrate binding site [chemical binding]; other site
653938004692	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
653938004693	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
653938004694	active site residue [active]
653938004695	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
653938004696	Uncharacterized conserved protein [Function unknown]; Region: COG1284
653938004697	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
653938004698	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
653938004699	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
653938004700	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
653938004701	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
653938004702	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
653938004703	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928
653938004704	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
653938004705	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
653938004706	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
653938004707	ligand binding site [chemical binding]; other site
653938004708	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
653938004709	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
653938004710	Walker A/P-loop; other site
653938004711	ATP binding site [chemical binding]; other site
653938004712	Q-loop/lid; other site
653938004713	ABC transporter signature motif; other site
653938004714	Walker B; other site
653938004715	D-loop; other site
653938004716	H-loop/switch region; other site
653938004717	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
653938004718	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
653938004719	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
653938004720	TM-ABC transporter signature motif; other site
653938004721	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
653938004722	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
653938004723	TM-ABC transporter signature motif; other site
653938004724	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
653938004725	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
653938004726	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
653938004727	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
653938004728	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
653938004729	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
653938004730	classical (c) SDRs; Region: SDR_c; cd05233
653938004731	NAD(P) binding site [chemical binding]; other site
653938004732	active site
653938004733	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
653938004734	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938004735	non-specific DNA binding site [nucleotide binding]; other site
653938004736	salt bridge; other site
653938004737	sequence-specific DNA binding site [nucleotide binding]; other site
653938004738	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
653938004739	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
653938004740	competence damage-inducible protein A; Provisional; Region: PRK00549
653938004741	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
653938004742	putative MPT binding site; other site
653938004743	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
653938004744	recombinase A; Provisional; Region: recA; PRK09354
653938004745	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
653938004746	hexamer interface [polypeptide binding]; other site
653938004747	Walker A motif; other site
653938004748	ATP binding site [chemical binding]; other site
653938004749	Walker B motif; other site
653938004750	phosphodiesterase; Provisional; Region: PRK12704
653938004751	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653938004752	Zn2+ binding site [ion binding]; other site
653938004753	Mg2+ binding site [ion binding]; other site
653938004754	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
653938004755	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938004756	Coenzyme A binding pocket [chemical binding]; other site
653938004757	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
653938004758	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
653938004759	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
653938004760	putative active site [active]
653938004761	metal binding site [ion binding]; metal-binding site
653938004762	homodimer binding site [polypeptide binding]; other site
653938004763	Predicted membrane protein [Function unknown]; Region: COG4550
653938004764	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
653938004765	MutS domain I; Region: MutS_I; pfam01624
653938004766	MutS domain II; Region: MutS_II; pfam05188
653938004767	MutS domain III; Region: MutS_III; pfam05192
653938004768	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
653938004769	Walker A/P-loop; other site
653938004770	ATP binding site [chemical binding]; other site
653938004771	Q-loop/lid; other site
653938004772	ABC transporter signature motif; other site
653938004773	Walker B; other site
653938004774	D-loop; other site
653938004775	H-loop/switch region; other site
653938004776	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
653938004777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938004778	ATP binding site [chemical binding]; other site
653938004779	Mg2+ binding site [ion binding]; other site
653938004780	G-X-G motif; other site
653938004781	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
653938004782	ATP binding site [chemical binding]; other site
653938004783	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
653938004784	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
653938004785	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
653938004786	Pyruvate formate lyase 1; Region: PFL1; cd01678
653938004787	coenzyme A binding site [chemical binding]; other site
653938004788	active site
653938004789	catalytic residues [active]
653938004790	glycine loop; other site
653938004791	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
653938004792	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653938004793	FeS/SAM binding site; other site
653938004794	Predicted transcriptional regulators [Transcription]; Region: COG1695
653938004795	Transcriptional regulator PadR-like family; Region: PadR; cl17335
653938004796	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938004797	putative substrate translocation pore; other site
653938004798	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938004799	non-specific DNA binding site [nucleotide binding]; other site
653938004800	salt bridge; other site
653938004801	sequence-specific DNA binding site [nucleotide binding]; other site
653938004802	topology modulation protein; Provisional; Region: PRK07261
653938004803	AAA domain; Region: AAA_17; pfam13207
653938004804	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938004805	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938004806	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938004807	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
653938004808	putative acyltransferase; Provisional; Region: PRK05790
653938004809	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
653938004810	dimer interface [polypeptide binding]; other site
653938004811	active site
653938004812	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
653938004813	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
653938004814	dimer interface [polypeptide binding]; other site
653938004815	active site
653938004816	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
653938004817	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
653938004818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938004819	putative substrate translocation pore; other site
653938004820	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
653938004821	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
653938004822	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
653938004823	Domain of unknown function DUF20; Region: UPF0118; pfam01594
653938004824	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
653938004825	FAD binding domain; Region: FAD_binding_4; pfam01565
653938004826	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
653938004827	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
653938004828	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
653938004829	Walker A/P-loop; other site
653938004830	ATP binding site [chemical binding]; other site
653938004831	Q-loop/lid; other site
653938004832	ABC transporter signature motif; other site
653938004833	Walker B; other site
653938004834	D-loop; other site
653938004835	H-loop/switch region; other site
653938004836	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
653938004837	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938004838	dimer interface [polypeptide binding]; other site
653938004839	conserved gate region; other site
653938004840	ABC-ATPase subunit interface; other site
653938004841	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
653938004842	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
653938004843	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
653938004844	manganese transport protein MntH; Reviewed; Region: PRK00701
653938004845	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
653938004846	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938004847	dimer interface [polypeptide binding]; other site
653938004848	conserved gate region; other site
653938004849	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
653938004850	ABC-ATPase subunit interface; other site
653938004851	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
653938004852	LysR substrate binding domain; Region: LysR_substrate; pfam03466
653938004853	dimerization interface [polypeptide binding]; other site
653938004854	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938004855	dimer interface [polypeptide binding]; other site
653938004856	conserved gate region; other site
653938004857	putative PBP binding loops; other site
653938004858	ABC-ATPase subunit interface; other site
653938004859	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
653938004860	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
653938004861	Walker A/P-loop; other site
653938004862	ATP binding site [chemical binding]; other site
653938004863	Q-loop/lid; other site
653938004864	ABC transporter signature motif; other site
653938004865	Walker B; other site
653938004866	D-loop; other site
653938004867	H-loop/switch region; other site
653938004868	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
653938004869	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491
653938004870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
653938004871	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
653938004872	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653938004873	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653938004874	ABC transporter; Region: ABC_tran_2; pfam12848
653938004875	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653938004876	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
653938004877	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
653938004878	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653938004879	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
653938004880	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
653938004881	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
653938004882	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
653938004883	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
653938004884	dihydrodipicolinate synthase; Region: dapA; TIGR00674
653938004885	dimer interface [polypeptide binding]; other site
653938004886	active site
653938004887	catalytic residue [active]
653938004888	aspartate kinase I; Reviewed; Region: PRK08210
653938004889	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
653938004890	nucleotide binding site [chemical binding]; other site
653938004891	substrate binding site [chemical binding]; other site
653938004892	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
653938004893	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
653938004894	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
653938004895	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
653938004896	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
653938004897	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
653938004898	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
653938004899	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
653938004900	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
653938004901	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
653938004902	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
653938004903	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
653938004904	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
653938004905	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
653938004906	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
653938004907	Predicted membrane protein [Function unknown]; Region: COG4392
653938004908	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
653938004909	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
653938004910	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
653938004911	metal binding site 2 [ion binding]; metal-binding site
653938004912	putative DNA binding helix; other site
653938004913	metal binding site 1 [ion binding]; metal-binding site
653938004914	dimer interface [polypeptide binding]; other site
653938004915	structural Zn2+ binding site [ion binding]; other site
653938004916	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
653938004917	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
653938004918	ABC-ATPase subunit  interface; other site
653938004919	dimer interface [polypeptide binding]; other site
653938004920	putative PBP binding regions; other site
653938004921	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
653938004922	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
653938004923	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
653938004924	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
653938004925	DHHA2 domain; Region: DHHA2; pfam02833
653938004926	endonuclease IV; Provisional; Region: PRK01060
653938004927	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
653938004928	AP (apurinic/apyrimidinic) site pocket; other site
653938004929	DNA interaction; other site
653938004930	Metal-binding active site; metal-binding site
653938004931	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
653938004932	DEAD-like helicases superfamily; Region: DEXDc; smart00487
653938004933	ATP binding site [chemical binding]; other site
653938004934	Mg++ binding site [ion binding]; other site
653938004935	motif III; other site
653938004936	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653938004937	nucleotide binding region [chemical binding]; other site
653938004938	ATP-binding site [chemical binding]; other site
653938004939	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
653938004940	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
653938004941	Uncharacterized conserved protein [Function unknown]; Region: COG0327
653938004942	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
653938004943	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
653938004944	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
653938004945	Uncharacterized conserved protein [Function unknown]; Region: COG0327
653938004946	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
653938004947	Family of unknown function (DUF633); Region: DUF633; pfam04816
653938004948	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
653938004949	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
653938004950	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
653938004951	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
653938004952	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
653938004953	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
653938004954	DNA binding residues [nucleotide binding]
653938004955	DNA primase; Validated; Region: dnaG; PRK05667
653938004956	CHC2 zinc finger; Region: zf-CHC2; pfam01807
653938004957	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
653938004958	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
653938004959	active site
653938004960	metal binding site [ion binding]; metal-binding site
653938004961	interdomain interaction site; other site
653938004962	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
653938004963	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
653938004964	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
653938004965	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
653938004966	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
653938004967	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
653938004968	dimer interface [polypeptide binding]; other site
653938004969	motif 1; other site
653938004970	active site
653938004971	motif 2; other site
653938004972	motif 3; other site
653938004973	DNA repair protein RecO; Region: reco; TIGR00613
653938004974	Recombination protein O N terminal; Region: RecO_N; pfam11967
653938004975	Recombination protein O C terminal; Region: RecO_C; pfam02565
653938004976	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
653938004977	GTPase Era; Reviewed; Region: era; PRK00089
653938004978	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
653938004979	G1 box; other site
653938004980	GTP/Mg2+ binding site [chemical binding]; other site
653938004981	Switch I region; other site
653938004982	G2 box; other site
653938004983	Switch II region; other site
653938004984	G3 box; other site
653938004985	G4 box; other site
653938004986	G5 box; other site
653938004987	KH domain; Region: KH_2; pfam07650
653938004988	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
653938004989	active site
653938004990	catalytic motif [active]
653938004991	Zn binding site [ion binding]; other site
653938004992	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
653938004993	metal-binding heat shock protein; Provisional; Region: PRK00016
653938004994	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
653938004995	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
653938004996	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653938004997	Zn2+ binding site [ion binding]; other site
653938004998	Mg2+ binding site [ion binding]; other site
653938004999	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
653938005000	PhoH-like protein; Region: PhoH; pfam02562
653938005001	Yqey-like protein; Region: YqeY; pfam09424
653938005002	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
653938005003	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
653938005004	RNA methyltransferase, RsmE family; Region: TIGR00046
653938005005	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
653938005006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938005007	S-adenosylmethionine binding site [chemical binding]; other site
653938005008	chaperone protein DnaJ; Provisional; Region: PRK14280
653938005009	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
653938005010	HSP70 interaction site [polypeptide binding]; other site
653938005011	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
653938005012	substrate binding site [polypeptide binding]; other site
653938005013	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
653938005014	Zn binding sites [ion binding]; other site
653938005015	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
653938005016	dimer interface [polypeptide binding]; other site
653938005017	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
653938005018	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
653938005019	nucleotide binding site [chemical binding]; other site
653938005020	NEF interaction site [polypeptide binding]; other site
653938005021	SBD interface [polypeptide binding]; other site
653938005022	heat shock protein GrpE; Provisional; Region: PRK14140
653938005023	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
653938005024	dimer interface [polypeptide binding]; other site
653938005025	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
653938005026	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
653938005027	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
653938005028	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
653938005029	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653938005030	FeS/SAM binding site; other site
653938005031	HemN C-terminal domain; Region: HemN_C; pfam06969
653938005032	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
653938005033	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
653938005034	NADP binding site [chemical binding]; other site
653938005035	putative substrate binding site [chemical binding]; other site
653938005036	active site
653938005037	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
653938005038	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
653938005039	DNA binding residues [nucleotide binding]
653938005040	putative dimer interface [polypeptide binding]; other site
653938005041	GTP-binding protein LepA; Provisional; Region: PRK05433
653938005042	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
653938005043	G1 box; other site
653938005044	putative GEF interaction site [polypeptide binding]; other site
653938005045	GTP/Mg2+ binding site [chemical binding]; other site
653938005046	Switch I region; other site
653938005047	G2 box; other site
653938005048	G3 box; other site
653938005049	Switch II region; other site
653938005050	G4 box; other site
653938005051	G5 box; other site
653938005052	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
653938005053	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
653938005054	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
653938005055	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
653938005056	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
653938005057	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
653938005058	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
653938005059	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
653938005060	Competence protein; Region: Competence; pfam03772
653938005061	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
653938005062	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
653938005063	catalytic motif [active]
653938005064	Zn binding site [ion binding]; other site
653938005065	SLBB domain; Region: SLBB; pfam10531
653938005066	comEA protein; Region: comE; TIGR01259
653938005067	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
653938005068	Methyltransferase domain; Region: Methyltransf_31; pfam13847
653938005069	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938005070	S-adenosylmethionine binding site [chemical binding]; other site
653938005071	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
653938005072	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653938005073	Zn2+ binding site [ion binding]; other site
653938005074	Mg2+ binding site [ion binding]; other site
653938005075	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
653938005076	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
653938005077	active site
653938005078	(T/H)XGH motif; other site
653938005079	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
653938005080	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
653938005081	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
653938005082	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
653938005083	shikimate binding site; other site
653938005084	NAD(P) binding site [chemical binding]; other site
653938005085	GTPase YqeH; Provisional; Region: PRK13796
653938005086	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
653938005087	GTP/Mg2+ binding site [chemical binding]; other site
653938005088	G4 box; other site
653938005089	G5 box; other site
653938005090	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
653938005091	G1 box; other site
653938005092	G1 box; other site
653938005093	GTP/Mg2+ binding site [chemical binding]; other site
653938005094	G2 box; other site
653938005095	Switch I region; other site
653938005096	G2 box; other site
653938005097	Switch I region; other site
653938005098	G3 box; other site
653938005099	G3 box; other site
653938005100	Switch II region; other site
653938005101	Switch II region; other site
653938005102	G4 box; other site
653938005103	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
653938005104	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938005105	motif II; other site
653938005106	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
653938005107	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
653938005108	active site
653938005109	Zn binding site [ion binding]; other site
653938005110	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
653938005111	Integrase core domain; Region: rve; pfam00665
653938005112	Integrase core domain; Region: rve_3; cl15866
653938005113	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
653938005114	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
653938005115	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
653938005116	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
653938005117	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
653938005118	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
653938005119	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
653938005120	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
653938005121	Sugar specificity; other site
653938005122	Pyrimidine base specificity; other site
653938005123	ATP-binding site [chemical binding]; other site
653938005124	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
653938005125	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938005126	S-adenosylmethionine binding site [chemical binding]; other site
653938005127	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
653938005128	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
653938005129	dimerization interface [polypeptide binding]; other site
653938005130	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
653938005131	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
653938005132	hypothetical protein; Provisional; Region: PRK13678
653938005133	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
653938005134	hypothetical protein; Provisional; Region: PRK05473
653938005135	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
653938005136	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
653938005137	active site
653938005138	motif 2; other site
653938005139	motif 3; other site
653938005140	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
653938005141	DHHA1 domain; Region: DHHA1; pfam02272
653938005142	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
653938005143	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653938005144	Walker A/P-loop; other site
653938005145	ATP binding site [chemical binding]; other site
653938005146	Q-loop/lid; other site
653938005147	ABC transporter signature motif; other site
653938005148	Walker B; other site
653938005149	D-loop; other site
653938005150	H-loop/switch region; other site
653938005151	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
653938005152	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
653938005153	FtsX-like permease family; Region: FtsX; pfam02687
653938005154	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
653938005155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938005156	active site
653938005157	phosphorylation site [posttranslational modification]
653938005158	intermolecular recognition site; other site
653938005159	dimerization interface [polypeptide binding]; other site
653938005160	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
653938005161	DNA binding site [nucleotide binding]
653938005162	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
653938005163	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653938005164	dimerization interface [polypeptide binding]; other site
653938005165	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653938005166	dimer interface [polypeptide binding]; other site
653938005167	phosphorylation site [posttranslational modification]
653938005168	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938005169	ATP binding site [chemical binding]; other site
653938005170	Mg2+ binding site [ion binding]; other site
653938005171	G-X-G motif; other site
653938005172	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
653938005173	AAA domain; Region: AAA_30; pfam13604
653938005174	Family description; Region: UvrD_C_2; pfam13538
653938005175	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653938005176	binding surface
653938005177	TPR motif; other site
653938005178	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
653938005179	TPR repeat; Region: TPR_11; pfam13414
653938005180	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653938005181	binding surface
653938005182	TPR motif; other site
653938005183	TPR repeat; Region: TPR_11; pfam13414
653938005184	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
653938005185	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
653938005186	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
653938005187	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
653938005188	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
653938005189	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
653938005190	catalytic residue [active]
653938005191	ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256
653938005192	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938005193	Walker A motif; other site
653938005194	ATP binding site [chemical binding]; other site
653938005195	Walker B motif; other site
653938005196	arginine finger; other site
653938005197	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
653938005198	Predicted transcriptional regulator [Transcription]; Region: COG1959
653938005199	Transcriptional regulator; Region: Rrf2; pfam02082
653938005200	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
653938005201	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
653938005202	Nitrogen regulatory protein P-II; Region: P-II; smart00938
653938005203	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
653938005204	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
653938005205	dimer interface [polypeptide binding]; other site
653938005206	anticodon binding site; other site
653938005207	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
653938005208	homodimer interface [polypeptide binding]; other site
653938005209	motif 1; other site
653938005210	active site
653938005211	motif 2; other site
653938005212	GAD domain; Region: GAD; pfam02938
653938005213	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
653938005214	active site
653938005215	motif 3; other site
653938005216	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
653938005217	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
653938005218	dimer interface [polypeptide binding]; other site
653938005219	motif 1; other site
653938005220	active site
653938005221	motif 2; other site
653938005222	motif 3; other site
653938005223	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
653938005224	anticodon binding site; other site
653938005225	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
653938005226	Bacterial SH3 domain; Region: SH3_3; pfam08239
653938005227	Bacterial SH3 domain; Region: SH3_3; pfam08239
653938005228	Bacterial SH3 domain homologues; Region: SH3b; smart00287
653938005229	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
653938005230	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
653938005231	active site
653938005232	metal binding site [ion binding]; metal-binding site
653938005233	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
653938005234	putative active site [active]
653938005235	dimerization interface [polypeptide binding]; other site
653938005236	putative tRNAtyr binding site [nucleotide binding]; other site
653938005237	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
653938005238	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653938005239	Zn2+ binding site [ion binding]; other site
653938005240	Mg2+ binding site [ion binding]; other site
653938005241	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
653938005242	synthetase active site [active]
653938005243	NTP binding site [chemical binding]; other site
653938005244	metal binding site [ion binding]; metal-binding site
653938005245	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
653938005246	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
653938005247	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653938005248	active site
653938005249	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
653938005250	DHH family; Region: DHH; pfam01368
653938005251	DHHA1 domain; Region: DHHA1; pfam02272
653938005252	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
653938005253	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
653938005254	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
653938005255	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
653938005256	Protein export membrane protein; Region: SecD_SecF; cl14618
653938005257	Protein export membrane protein; Region: SecD_SecF; pfam02355
653938005258	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
653938005259	Preprotein translocase subunit; Region: YajC; pfam02699
653938005260	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
653938005261	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
653938005262	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
653938005263	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
653938005264	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
653938005265	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938005266	Walker A motif; other site
653938005267	ATP binding site [chemical binding]; other site
653938005268	Walker B motif; other site
653938005269	arginine finger; other site
653938005270	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
653938005271	Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
653938005272	RuvA N terminal domain; Region: RuvA_N; pfam01330
653938005273	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
653938005274	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
653938005275	tetramer (dimer of dimers) interface [polypeptide binding]; other site
653938005276	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
653938005277	NAD binding site [chemical binding]; other site
653938005278	dimer interface [polypeptide binding]; other site
653938005279	substrate binding site [chemical binding]; other site
653938005280	hypothetical protein; Validated; Region: PRK00110
653938005281	prephenate dehydratase; Provisional; Region: PRK11898
653938005282	Prephenate dehydratase; Region: PDT; pfam00800
653938005283	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
653938005284	putative L-Phe binding site [chemical binding]; other site
653938005285	GTPase CgtA; Reviewed; Region: obgE; PRK12297
653938005286	GTP1/OBG; Region: GTP1_OBG; pfam01018
653938005287	Obg GTPase; Region: Obg; cd01898
653938005288	G1 box; other site
653938005289	GTP/Mg2+ binding site [chemical binding]; other site
653938005290	Switch I region; other site
653938005291	G2 box; other site
653938005292	G3 box; other site
653938005293	Switch II region; other site
653938005294	G4 box; other site
653938005295	G5 box; other site
653938005296	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
653938005297	glycerol kinase; Provisional; Region: glpK; PRK00047
653938005298	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
653938005299	N- and C-terminal domain interface [polypeptide binding]; other site
653938005300	active site
653938005301	MgATP binding site [chemical binding]; other site
653938005302	catalytic site [active]
653938005303	metal binding site [ion binding]; metal-binding site
653938005304	glycerol binding site [chemical binding]; other site
653938005305	homotetramer interface [polypeptide binding]; other site
653938005306	homodimer interface [polypeptide binding]; other site
653938005307	FBP binding site [chemical binding]; other site
653938005308	protein IIAGlc interface [polypeptide binding]; other site
653938005309	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
653938005310	amphipathic channel; other site
653938005311	Asn-Pro-Ala signature motifs; other site
653938005312	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
653938005313	hypothetical protein; Provisional; Region: PRK14553
653938005314	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
653938005315	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
653938005316	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
653938005317	homodimer interface [polypeptide binding]; other site
653938005318	oligonucleotide binding site [chemical binding]; other site
653938005319	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
653938005320	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
653938005321	Switch I; other site
653938005322	Switch II; other site
653938005323	septum formation inhibitor; Reviewed; Region: minC; PRK00513
653938005324	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
653938005325	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
653938005326	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
653938005327	Protein of unknown function (DUF972); Region: DUF972; pfam06156
653938005328	rod shape-determining protein MreC; Region: MreC; pfam04085
653938005329	rod shape-determining protein MreB; Provisional; Region: PRK13927
653938005330	MreB and similar proteins; Region: MreB_like; cd10225
653938005331	nucleotide binding site [chemical binding]; other site
653938005332	Mg binding site [ion binding]; other site
653938005333	putative protofilament interaction site [polypeptide binding]; other site
653938005334	RodZ interaction site [polypeptide binding]; other site
653938005335	hypothetical protein; Reviewed; Region: PRK00024
653938005336	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
653938005337	MPN+ (JAMM) motif; other site
653938005338	Zinc-binding site [ion binding]; other site
653938005339	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
653938005340	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
653938005341	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
653938005342	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
653938005343	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
653938005344	AAA domain; Region: AAA_14; pfam13173
653938005345	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
653938005346	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
653938005347	active site
653938005348	HIGH motif; other site
653938005349	nucleotide binding site [chemical binding]; other site
653938005350	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
653938005351	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
653938005352	active site
653938005353	KMSKS motif; other site
653938005354	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
653938005355	tRNA binding surface [nucleotide binding]; other site
653938005356	anticodon binding site; other site
653938005357	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
653938005358	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
653938005359	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
653938005360	inhibitor-cofactor binding pocket; inhibition site
653938005361	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938005362	catalytic residue [active]
653938005363	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
653938005364	dimer interface [polypeptide binding]; other site
653938005365	active site
653938005366	Schiff base residues; other site
653938005367	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
653938005368	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
653938005369	active site
653938005370	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
653938005371	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
653938005372	domain interfaces; other site
653938005373	active site
653938005374	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
653938005375	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
653938005376	tRNA; other site
653938005377	putative tRNA binding site [nucleotide binding]; other site
653938005378	putative NADP binding site [chemical binding]; other site
653938005379	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
653938005380	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
653938005381	G1 box; other site
653938005382	GTP/Mg2+ binding site [chemical binding]; other site
653938005383	Switch I region; other site
653938005384	G2 box; other site
653938005385	G3 box; other site
653938005386	Switch II region; other site
653938005387	G4 box; other site
653938005388	G5 box; other site
653938005389	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
653938005390	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
653938005391	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
653938005392	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
653938005393	active site
653938005394	dimer interface [polypeptide binding]; other site
653938005395	motif 1; other site
653938005396	motif 2; other site
653938005397	motif 3; other site
653938005398	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
653938005399	anticodon binding site; other site
653938005400	primosomal protein DnaI; Reviewed; Region: PRK08939
653938005401	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
653938005402	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
653938005403	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
653938005404	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
653938005405	ATP cone domain; Region: ATP-cone; pfam03477
653938005406	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
653938005407	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
653938005408	CoA-binding site [chemical binding]; other site
653938005409	ATP-binding [chemical binding]; other site
653938005410	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
653938005411	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
653938005412	DNA binding site [nucleotide binding]
653938005413	catalytic residue [active]
653938005414	H2TH interface [polypeptide binding]; other site
653938005415	putative catalytic residues [active]
653938005416	turnover-facilitating residue; other site
653938005417	intercalation triad [nucleotide binding]; other site
653938005418	8OG recognition residue [nucleotide binding]; other site
653938005419	putative reading head residues; other site
653938005420	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
653938005421	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
653938005422	DNA polymerase I; Provisional; Region: PRK05755
653938005423	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
653938005424	active site
653938005425	metal binding site 1 [ion binding]; metal-binding site
653938005426	putative 5' ssDNA interaction site; other site
653938005427	metal binding site 3; metal-binding site
653938005428	metal binding site 2 [ion binding]; metal-binding site
653938005429	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
653938005430	putative DNA binding site [nucleotide binding]; other site
653938005431	putative metal binding site [ion binding]; other site
653938005432	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
653938005433	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
653938005434	active site
653938005435	DNA binding site [nucleotide binding]
653938005436	catalytic site [active]
653938005437	isocitrate dehydrogenase; Reviewed; Region: PRK07006
653938005438	isocitrate dehydrogenase; Validated; Region: PRK07362
653938005439	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
653938005440	dimer interface [polypeptide binding]; other site
653938005441	Citrate synthase; Region: Citrate_synt; pfam00285
653938005442	active site
653938005443	citrylCoA binding site [chemical binding]; other site
653938005444	oxalacetate/citrate binding site [chemical binding]; other site
653938005445	coenzyme A binding site [chemical binding]; other site
653938005446	catalytic triad [active]
653938005447	Protein of unknown function (DUF441); Region: DUF441; pfam04284
653938005448	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
653938005449	pyruvate kinase; Provisional; Region: PRK06354
653938005450	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
653938005451	domain interfaces; other site
653938005452	active site
653938005453	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
653938005454	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
653938005455	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
653938005456	active site
653938005457	ADP/pyrophosphate binding site [chemical binding]; other site
653938005458	dimerization interface [polypeptide binding]; other site
653938005459	allosteric effector site; other site
653938005460	fructose-1,6-bisphosphate binding site; other site
653938005461	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
653938005462	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
653938005463	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
653938005464	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
653938005465	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
653938005466	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
653938005467	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
653938005468	active site
653938005469	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
653938005470	generic binding surface I; other site
653938005471	generic binding surface II; other site
653938005472	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
653938005473	DHH family; Region: DHH; pfam01368
653938005474	DHHA1 domain; Region: DHHA1; pfam02272
653938005475	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
653938005476	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
653938005477	DNA-binding site [nucleotide binding]; DNA binding site
653938005478	DRTGG domain; Region: DRTGG; pfam07085
653938005479	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
653938005480	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
653938005481	active site 2 [active]
653938005482	active site 1 [active]
653938005483	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
653938005484	metal-dependent hydrolase; Provisional; Region: PRK00685
653938005485	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
653938005486	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
653938005487	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
653938005488	active site
653938005489	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
653938005490	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
653938005491	hexamer interface [polypeptide binding]; other site
653938005492	ligand binding site [chemical binding]; other site
653938005493	putative active site [active]
653938005494	NAD(P) binding site [chemical binding]; other site
653938005495	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
653938005496	Ligand Binding Site [chemical binding]; other site
653938005497	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
653938005498	propionate/acetate kinase; Provisional; Region: PRK12379
653938005499	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
653938005500	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938005501	S-adenosylmethionine binding site [chemical binding]; other site
653938005502	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
653938005503	dimer interface [polypeptide binding]; other site
653938005504	catalytic triad [active]
653938005505	peroxidatic and resolving cysteines [active]
653938005506	RDD family; Region: RDD; pfam06271
653938005507	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
653938005508	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
653938005509	tandem repeat interface [polypeptide binding]; other site
653938005510	oligomer interface [polypeptide binding]; other site
653938005511	active site residues [active]
653938005512	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
653938005513	ATP-NAD kinase; Region: NAD_kinase; pfam01513
653938005514	ornithine carbamoyltransferase; Provisional; Region: PRK00779
653938005515	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
653938005516	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
653938005517	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
653938005518	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
653938005519	inhibitor-cofactor binding pocket; inhibition site
653938005520	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938005521	catalytic residue [active]
653938005522	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
653938005523	nucleotide binding site [chemical binding]; other site
653938005524	N-acetyl-L-glutamate binding site [chemical binding]; other site
653938005525	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
653938005526	heterotetramer interface [polypeptide binding]; other site
653938005527	active site pocket [active]
653938005528	cleavage site
653938005529	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
653938005530	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
653938005531	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
653938005532	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
653938005533	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
653938005534	Ligand Binding Site [chemical binding]; other site
653938005535	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
653938005536	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
653938005537	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
653938005538	catalytic residue [active]
653938005539	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
653938005540	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
653938005541	GAF domain; Region: GAF_2; pfam13185
653938005542	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
653938005543	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
653938005544	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
653938005545	RNA binding surface [nucleotide binding]; other site
653938005546	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
653938005547	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
653938005548	active site
653938005549	HIGH motif; other site
653938005550	dimer interface [polypeptide binding]; other site
653938005551	KMSKS motif; other site
653938005552	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
653938005553	RNA binding surface [nucleotide binding]; other site
653938005554	catabolite control protein A; Region: ccpA; TIGR01481
653938005555	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
653938005556	DNA binding site [nucleotide binding]
653938005557	domain linker motif; other site
653938005558	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
653938005559	dimerization interface [polypeptide binding]; other site
653938005560	effector binding site; other site
653938005561	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
653938005562	Chorismate mutase type II; Region: CM_2; cl00693
653938005563	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
653938005564	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
653938005565	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
653938005566	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
653938005567	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
653938005568	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
653938005569	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
653938005570	dimer interface [polypeptide binding]; other site
653938005571	decamer (pentamer of dimers) interface [polypeptide binding]; other site
653938005572	catalytic triad [active]
653938005573	peroxidatic and resolving cysteines [active]
653938005574	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
653938005575	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
653938005576	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
653938005577	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
653938005578	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
653938005579	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
653938005580	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
653938005581	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
653938005582	putative tRNA-binding site [nucleotide binding]; other site
653938005583	hypothetical protein; Provisional; Region: PRK13668
653938005584	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
653938005585	catalytic residues [active]
653938005586	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
653938005587	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
653938005588	oligomer interface [polypeptide binding]; other site
653938005589	active site
653938005590	metal binding site [ion binding]; metal-binding site
653938005591	Predicted small secreted protein [Function unknown]; Region: COG5584
653938005592	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937
653938005593	putative homodimer interface [polypeptide binding]; other site
653938005594	putative homotetramer interface [polypeptide binding]; other site
653938005595	putative allosteric switch controlling residues; other site
653938005596	putative metal binding site [ion binding]; other site
653938005597	putative homodimer-homodimer interface [polypeptide binding]; other site
653938005598	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
653938005599	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938005600	S-adenosylmethionine binding site [chemical binding]; other site
653938005601	Phosphotransferase enzyme family; Region: APH; pfam01636
653938005602	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
653938005603	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
653938005604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938005605	putative substrate translocation pore; other site
653938005606	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938005607	MarR family; Region: MarR; pfam01047
653938005608	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
653938005609	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
653938005610	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
653938005611	homodimer interface [polypeptide binding]; other site
653938005612	substrate-cofactor binding pocket; other site
653938005613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938005614	catalytic residue [active]
653938005615	dipeptidase PepV; Reviewed; Region: PRK07318
653938005616	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
653938005617	active site
653938005618	metal binding site [ion binding]; metal-binding site
653938005619	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699
653938005620	nudix motif; other site
653938005621	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
653938005622	putative substrate binding site [chemical binding]; other site
653938005623	putative ATP binding site [chemical binding]; other site
653938005624	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
653938005625	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
653938005626	active site
653938005627	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
653938005628	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
653938005629	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
653938005630	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
653938005631	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
653938005632	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
653938005633	substrate binding site [chemical binding]; other site
653938005634	active site
653938005635	catalytic residues [active]
653938005636	heterodimer interface [polypeptide binding]; other site
653938005637	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
653938005638	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
653938005639	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938005640	catalytic residue [active]
653938005641	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
653938005642	active site
653938005643	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
653938005644	active site
653938005645	ribulose/triose binding site [chemical binding]; other site
653938005646	phosphate binding site [ion binding]; other site
653938005647	substrate (anthranilate) binding pocket [chemical binding]; other site
653938005648	product (indole) binding pocket [chemical binding]; other site
653938005649	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
653938005650	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
653938005651	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
653938005652	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
653938005653	Glutamine amidotransferase class-I; Region: GATase; pfam00117
653938005654	glutamine binding [chemical binding]; other site
653938005655	catalytic triad [active]
653938005656	anthranilate synthase component I; Provisional; Region: PRK13570
653938005657	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
653938005658	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
653938005659	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
653938005660	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
653938005661	putative catalytic cysteine [active]
653938005662	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
653938005663	putative active site [active]
653938005664	metal binding site [ion binding]; metal-binding site
653938005665	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
653938005666	dimer interface [polypeptide binding]; other site
653938005667	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
653938005668	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938005669	Walker A/P-loop; other site
653938005670	ATP binding site [chemical binding]; other site
653938005671	Q-loop/lid; other site
653938005672	ABC transporter signature motif; other site
653938005673	Walker B; other site
653938005674	D-loop; other site
653938005675	H-loop/switch region; other site
653938005676	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
653938005677	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
653938005678	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
653938005679	putative dimer interface [polypeptide binding]; other site
653938005680	catalytic triad [active]
653938005681	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
653938005682	aconitate hydratase; Validated; Region: PRK09277
653938005683	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
653938005684	substrate binding site [chemical binding]; other site
653938005685	ligand binding site [chemical binding]; other site
653938005686	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
653938005687	substrate binding site [chemical binding]; other site
653938005688	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
653938005689	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
653938005690	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
653938005691	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653938005692	ATP binding site [chemical binding]; other site
653938005693	putative Mg++ binding site [ion binding]; other site
653938005694	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653938005695	nucleotide binding region [chemical binding]; other site
653938005696	ATP-binding site [chemical binding]; other site
653938005697	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
653938005698	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
653938005699	Walker A/P-loop; other site
653938005700	ATP binding site [chemical binding]; other site
653938005701	Q-loop/lid; other site
653938005702	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
653938005703	ABC transporter signature motif; other site
653938005704	Walker B; other site
653938005705	D-loop; other site
653938005706	H-loop/switch region; other site
653938005707	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
653938005708	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
653938005709	active site
653938005710	metal binding site [ion binding]; metal-binding site
653938005711	DNA binding site [nucleotide binding]
653938005712	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
653938005713	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
653938005714	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
653938005715	putative acyl-acceptor binding pocket; other site
653938005716	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
653938005717	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
653938005718	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
653938005719	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653938005720	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
653938005721	Walker A/P-loop; other site
653938005722	ATP binding site [chemical binding]; other site
653938005723	Q-loop/lid; other site
653938005724	ABC transporter signature motif; other site
653938005725	Walker B; other site
653938005726	D-loop; other site
653938005727	H-loop/switch region; other site
653938005728	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653938005729	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
653938005730	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938005731	Walker A/P-loop; other site
653938005732	ATP binding site [chemical binding]; other site
653938005733	Q-loop/lid; other site
653938005734	ABC transporter signature motif; other site
653938005735	Walker B; other site
653938005736	D-loop; other site
653938005737	H-loop/switch region; other site
653938005738	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
653938005739	active site
653938005740	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
653938005741	elongation factor Ts; Provisional; Region: tsf; PRK09377
653938005742	UBA/TS-N domain; Region: UBA; pfam00627
653938005743	Elongation factor TS; Region: EF_TS; pfam00889
653938005744	Elongation factor TS; Region: EF_TS; pfam00889
653938005745	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
653938005746	rRNA interaction site [nucleotide binding]; other site
653938005747	S8 interaction site; other site
653938005748	putative laminin-1 binding site; other site
653938005749	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
653938005750	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
653938005751	HIGH motif; other site
653938005752	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
653938005753	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
653938005754	active site
653938005755	KMSKS motif; other site
653938005756	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
653938005757	tRNA binding surface [nucleotide binding]; other site
653938005758	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
653938005759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938005760	S-adenosylmethionine binding site [chemical binding]; other site
653938005761	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
653938005762	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
653938005763	active site
653938005764	dimer interface [polypeptide binding]; other site
653938005765	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
653938005766	Ligand Binding Site [chemical binding]; other site
653938005767	Molecular Tunnel; other site
653938005768	S-adenosylmethionine synthetase; Validated; Region: PRK05250
653938005769	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
653938005770	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
653938005771	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
653938005772	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
653938005773	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
653938005774	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
653938005775	tetramer (dimer of dimers) interface [polypeptide binding]; other site
653938005776	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
653938005777	NAD binding site [chemical binding]; other site
653938005778	dimer interface [polypeptide binding]; other site
653938005779	substrate binding site [chemical binding]; other site
653938005780	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
653938005781	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
653938005782	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
653938005783	nudix motif; other site
653938005784	Uncharacterized conserved protein [Function unknown]; Region: COG0759
653938005785	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
653938005786	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
653938005787	metal binding site [ion binding]; metal-binding site
653938005788	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
653938005789	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
653938005790	acyl-activating enzyme (AAE) consensus motif; other site
653938005791	putative AMP binding site [chemical binding]; other site
653938005792	putative active site [active]
653938005793	putative CoA binding site [chemical binding]; other site
653938005794	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
653938005795	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
653938005796	substrate binding site [chemical binding]; other site
653938005797	oxyanion hole (OAH) forming residues; other site
653938005798	trimer interface [polypeptide binding]; other site
653938005799	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
653938005800	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
653938005801	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
653938005802	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
653938005803	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
653938005804	dimer interface [polypeptide binding]; other site
653938005805	tetramer interface [polypeptide binding]; other site
653938005806	PYR/PP interface [polypeptide binding]; other site
653938005807	TPP binding site [chemical binding]; other site
653938005808	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
653938005809	TPP-binding site; other site
653938005810	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
653938005811	chorismate binding enzyme; Region: Chorismate_bind; cl10555
653938005812	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
653938005813	UbiA prenyltransferase family; Region: UbiA; pfam01040
653938005814	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
653938005815	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
653938005816	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
653938005817	FAD binding site [chemical binding]; other site
653938005818	cystathionine beta-lyase; Provisional; Region: PRK08064
653938005819	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
653938005820	homodimer interface [polypeptide binding]; other site
653938005821	substrate-cofactor binding pocket; other site
653938005822	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938005823	catalytic residue [active]
653938005824	cystathionine gamma-synthase; Reviewed; Region: PRK08247
653938005825	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
653938005826	homodimer interface [polypeptide binding]; other site
653938005827	substrate-cofactor binding pocket; other site
653938005828	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938005829	catalytic residue [active]
653938005830	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
653938005831	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
653938005832	THF binding site; other site
653938005833	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
653938005834	substrate binding site [chemical binding]; other site
653938005835	THF binding site; other site
653938005836	zinc-binding site [ion binding]; other site
653938005837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938005838	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653938005839	putative substrate translocation pore; other site
653938005840	ferric uptake regulator; Provisional; Region: fur; PRK09462
653938005841	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
653938005842	metal binding site 2 [ion binding]; metal-binding site
653938005843	putative DNA binding helix; other site
653938005844	metal binding site 1 [ion binding]; metal-binding site
653938005845	dimer interface [polypeptide binding]; other site
653938005846	structural Zn2+ binding site [ion binding]; other site
653938005847	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
653938005848	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
653938005849	NAD binding site [chemical binding]; other site
653938005850	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
653938005851	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
653938005852	inhibitor-cofactor binding pocket; inhibition site
653938005853	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938005854	catalytic residue [active]
653938005855	Predicted membrane protein [Function unknown]; Region: COG4129
653938005856	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
653938005857	hypothetical protein; Provisional; Region: PRK13662
653938005858	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
653938005859	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
653938005860	putative NAD(P) binding site [chemical binding]; other site
653938005861	active site
653938005862	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
653938005863	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
653938005864	minor groove reading motif; other site
653938005865	helix-hairpin-helix signature motif; other site
653938005866	substrate binding pocket [chemical binding]; other site
653938005867	active site
653938005868	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
653938005869	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
653938005870	DNA binding and oxoG recognition site [nucleotide binding]
653938005871	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
653938005872	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
653938005873	trimer interface [polypeptide binding]; other site
653938005874	active site
653938005875	WVELL protein; Region: WVELL; pfam14043
653938005876	recombination regulator RecX; Provisional; Region: recX; PRK14135
653938005877	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
653938005878	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
653938005879	NAD(P) binding site [chemical binding]; other site
653938005880	active site
653938005881	Predicted integral membrane protein [Function unknown]; Region: COG0392
653938005882	Uncharacterized conserved protein [Function unknown]; Region: COG2898
653938005883	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
653938005884	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
653938005885	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
653938005886	Cation efflux family; Region: Cation_efflux; pfam01545
653938005887	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
653938005888	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
653938005889	PAS fold; Region: PAS_4; pfam08448
653938005890	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653938005891	putative active site [active]
653938005892	heme pocket [chemical binding]; other site
653938005893	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
653938005894	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653938005895	dimer interface [polypeptide binding]; other site
653938005896	putative CheW interface [polypeptide binding]; other site
653938005897	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
653938005898	FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364
653938005899	dimer interface [polypeptide binding]; other site
653938005900	active site
653938005901	Mn binding site [ion binding]; other site
653938005902	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
653938005903	Copper-binding of amyloid precursor, CuBD; Region: APP_Cu_bd; pfam12924
653938005904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
653938005905	active site
653938005906	phosphorylation site [posttranslational modification]
653938005907	intermolecular recognition site; other site
653938005908	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
653938005909	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653938005910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938005911	ATP binding site [chemical binding]; other site
653938005912	Mg2+ binding site [ion binding]; other site
653938005913	G-X-G motif; other site
653938005914	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
653938005915	Methyltransferase domain; Region: Methyltransf_26; pfam13659
653938005916	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
653938005917	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
653938005918	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
653938005919	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
653938005920	catalytic residues [active]
653938005921	catalytic nucleophile [active]
653938005922	Recombinase; Region: Recombinase; pfam07508
653938005923	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
653938005924	Recombinase; Region: Recombinase; pfam07508
653938005925	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
653938005926	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
653938005927	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
653938005928	catalytic residues [active]
653938005929	catalytic nucleophile [active]
653938005930	Recombinase; Region: Recombinase; pfam07508
653938005931	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
653938005932	Resolvase, N terminal domain; Region: Resolvase; smart00857
653938005933	catalytic residues [active]
653938005934	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
653938005935	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
653938005936	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
653938005937	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
653938005938	Helix-turn-helix domain; Region: HTH_36; pfam13730
653938005939	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
653938005940	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
653938005941	Walker A motif; other site
653938005942	ATP binding site [chemical binding]; other site
653938005943	Walker B motif; other site
653938005944	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
653938005945	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
653938005946	active site
653938005947	metal binding site [ion binding]; metal-binding site
653938005948	interdomain interaction site; other site
653938005949	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
653938005950	Sel1-like repeats; Region: SEL1; smart00671
653938005951	Sel1-like repeats; Region: SEL1; smart00671
653938005952	Sel1-like repeats; Region: SEL1; smart00671
653938005953	Sel1-like repeats; Region: SEL1; smart00671
653938005954	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
653938005955	Sel1-like repeats; Region: SEL1; smart00671
653938005956	Sel1-like repeats; Region: SEL1; smart00671
653938005957	Sel1-like repeats; Region: SEL1; smart00671
653938005958	Sel1-like repeats; Region: SEL1; smart00671
653938005959	Sel1-like repeats; Region: SEL1; smart00671
653938005960	HNH endonuclease; Region: HNH_5; pfam14279
653938005961	Protein of unknown function (DUF3782); Region: DUF3782; pfam12644
653938005962	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
653938005963	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
653938005964	NlpC/P60 family; Region: NLPC_P60; pfam00877
653938005965	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
653938005966	putative active site pocket [active]
653938005967	dimerization interface [polypeptide binding]; other site
653938005968	putative catalytic residue [active]
653938005969	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
653938005970	AAA-like domain; Region: AAA_10; pfam12846
653938005971	NTPase; Region: NTPase_1; cl17478
653938005972	Protein of unknown function (DUF3852); Region: DUF3852; pfam12963
653938005973	Domain of unknown function (DUF4320); Region: DUF4320; pfam14208
653938005974	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
653938005975	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
653938005976	Walker A motif; other site
653938005977	ATP binding site [chemical binding]; other site
653938005978	Walker B motif; other site
653938005979	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
653938005980	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
653938005981	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
653938005982	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
653938005983	SpoVG; Region: SpoVG; pfam04026
653938005984	YodL-like; Region: YodL; pfam14191
653938005985	cell division protein MraZ; Reviewed; Region: PRK00326
653938005986	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
653938005987	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
653938005988	PLD-like domain; Region: PLDc_2; pfam13091
653938005989	putative active site [active]
653938005990	catalytic site [active]
653938005991	TRAM domain; Region: TRAM; cl01282
653938005992	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
653938005993	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938005994	S-adenosylmethionine binding site [chemical binding]; other site
653938005995	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
653938005996	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
653938005997	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
653938005998	Substrate-binding site [chemical binding]; other site
653938005999	Substrate specificity [chemical binding]; other site
653938006000	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
653938006001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840
653938006002	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
653938006003	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
653938006004	active site
653938006005	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
653938006006	flavodoxin, short chain; Region: flav_short; TIGR01753
653938006007	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
653938006008	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
653938006009	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938006010	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653938006011	putative substrate translocation pore; other site
653938006012	rod-share determining protein MreBH; Provisional; Region: PRK13929
653938006013	MreB and similar proteins; Region: MreB_like; cd10225
653938006014	nucleotide binding site [chemical binding]; other site
653938006015	Mg binding site [ion binding]; other site
653938006016	putative protofilament interaction site [polypeptide binding]; other site
653938006017	RodZ interaction site [polypeptide binding]; other site
653938006018	Methyltransferase domain; Region: Methyltransf_31; pfam13847
653938006019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938006020	S-adenosylmethionine binding site [chemical binding]; other site
653938006021	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
653938006022	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
653938006023	Uncharacterized conserved protein [Function unknown]; Region: COG3589
653938006024	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
653938006025	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
653938006026	methionine cluster; other site
653938006027	active site
653938006028	phosphorylation site [posttranslational modification]
653938006029	metal binding site [ion binding]; metal-binding site
653938006030	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
653938006031	active site
653938006032	P-loop; other site
653938006033	phosphorylation site [posttranslational modification]
653938006034	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
653938006035	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
653938006036	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938006037	Walker A motif; other site
653938006038	ATP binding site [chemical binding]; other site
653938006039	Walker B motif; other site
653938006040	arginine finger; other site
653938006041	Transcriptional antiterminator [Transcription]; Region: COG3933
653938006042	PRD domain; Region: PRD; pfam00874
653938006043	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
653938006044	active pocket/dimerization site; other site
653938006045	active site
653938006046	phosphorylation site [posttranslational modification]
653938006047	PRD domain; Region: PRD; pfam00874
653938006048	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
653938006049	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
653938006050	ATP binding site [chemical binding]; other site
653938006051	putative Mg++ binding site [ion binding]; other site
653938006052	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653938006053	nucleotide binding region [chemical binding]; other site
653938006054	ATP-binding site [chemical binding]; other site
653938006055	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
653938006056	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
653938006057	Walker A/P-loop; other site
653938006058	ATP binding site [chemical binding]; other site
653938006059	Q-loop/lid; other site
653938006060	ABC transporter signature motif; other site
653938006061	Walker B; other site
653938006062	D-loop; other site
653938006063	H-loop/switch region; other site
653938006064	Predicted transcriptional regulators [Transcription]; Region: COG1725
653938006065	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938006066	DNA-binding site [nucleotide binding]; DNA binding site
653938006067	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
653938006068	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
653938006069	Transcriptional regulators [Transcription]; Region: PurR; COG1609
653938006070	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
653938006071	DNA binding site [nucleotide binding]
653938006072	domain linker motif; other site
653938006073	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
653938006074	dimerization interface [polypeptide binding]; other site
653938006075	ligand binding site [chemical binding]; other site
653938006076	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
653938006077	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
653938006078	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
653938006079	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
653938006080	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
653938006081	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
653938006082	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938006083	dimer interface [polypeptide binding]; other site
653938006084	conserved gate region; other site
653938006085	putative PBP binding loops; other site
653938006086	ABC-ATPase subunit interface; other site
653938006087	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
653938006088	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938006089	dimer interface [polypeptide binding]; other site
653938006090	conserved gate region; other site
653938006091	putative PBP binding loops; other site
653938006092	ABC-ATPase subunit interface; other site
653938006093	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
653938006094	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
653938006095	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
653938006096	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
653938006097	active site
653938006098	dimer interface [polypeptide binding]; other site
653938006099	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
653938006100	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
653938006101	active site
653938006102	FMN binding site [chemical binding]; other site
653938006103	substrate binding site [chemical binding]; other site
653938006104	3Fe-4S cluster binding site [ion binding]; other site
653938006105	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
653938006106	domain interface; other site
653938006107	Transcriptional regulator [Transcription]; Region: LysR; COG0583
653938006108	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
653938006109	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
653938006110	putative dimerization interface [polypeptide binding]; other site
653938006111	Predicted acetyltransferase [General function prediction only]; Region: COG3153
653938006112	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
653938006113	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
653938006114	putative active site [active]
653938006115	metal binding site [ion binding]; metal-binding site
653938006116	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
653938006117	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
653938006118	substrate binding pocket [chemical binding]; other site
653938006119	membrane-bound complex binding site; other site
653938006120	hinge residues; other site
653938006121	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
653938006122	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938006123	Walker A/P-loop; other site
653938006124	ATP binding site [chemical binding]; other site
653938006125	Q-loop/lid; other site
653938006126	ABC transporter signature motif; other site
653938006127	Walker B; other site
653938006128	D-loop; other site
653938006129	H-loop/switch region; other site
653938006130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938006131	dimer interface [polypeptide binding]; other site
653938006132	conserved gate region; other site
653938006133	putative PBP binding loops; other site
653938006134	ABC-ATPase subunit interface; other site
653938006135	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653938006136	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
653938006137	dimer interface [polypeptide binding]; other site
653938006138	phosphorylation site [posttranslational modification]
653938006139	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938006140	ATP binding site [chemical binding]; other site
653938006141	Mg2+ binding site [ion binding]; other site
653938006142	G-X-G motif; other site
653938006143	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
653938006144	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
653938006145	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
653938006146	active site
653938006147	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
653938006148	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
653938006149	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
653938006150	putative NAD(P) binding site [chemical binding]; other site
653938006151	active site
653938006152	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
653938006153	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938006154	active site
653938006155	phosphorylation site [posttranslational modification]
653938006156	intermolecular recognition site; other site
653938006157	dimerization interface [polypeptide binding]; other site
653938006158	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
653938006159	DNA binding site [nucleotide binding]
653938006160	FtsX-like permease family; Region: FtsX; pfam02687
653938006161	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
653938006162	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
653938006163	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653938006164	Walker A/P-loop; other site
653938006165	ATP binding site [chemical binding]; other site
653938006166	Q-loop/lid; other site
653938006167	ABC transporter signature motif; other site
653938006168	Walker B; other site
653938006169	D-loop; other site
653938006170	H-loop/switch region; other site
653938006171	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
653938006172	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
653938006173	ADP binding site [chemical binding]; other site
653938006174	magnesium binding site [ion binding]; other site
653938006175	putative shikimate binding site; other site
653938006176	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884
653938006177	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
653938006178	TRAM domain; Region: TRAM; pfam01938
653938006179	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938006180	S-adenosylmethionine binding site [chemical binding]; other site
653938006181	putative lipid kinase; Reviewed; Region: PRK13337
653938006182	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
653938006183	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
653938006184	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
653938006185	GatB domain; Region: GatB_Yqey; pfam02637
653938006186	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
653938006187	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
653938006188	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
653938006189	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
653938006190	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
653938006191	putative dimer interface [polypeptide binding]; other site
653938006192	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
653938006193	putative dimer interface [polypeptide binding]; other site
653938006194	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
653938006195	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
653938006196	nucleotide binding pocket [chemical binding]; other site
653938006197	K-X-D-G motif; other site
653938006198	catalytic site [active]
653938006199	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
653938006200	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
653938006201	Dimer interface [polypeptide binding]; other site
653938006202	BRCT sequence motif; other site
653938006203	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
653938006204	Part of AAA domain; Region: AAA_19; pfam13245
653938006205	Family description; Region: UvrD_C_2; pfam13538
653938006206	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
653938006207	PcrB family; Region: PcrB; pfam01884
653938006208	substrate binding site [chemical binding]; other site
653938006209	putative active site [active]
653938006210	dimer interface [polypeptide binding]; other site
653938006211	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
653938006212	Na2 binding site [ion binding]; other site
653938006213	putative substrate binding site 1 [chemical binding]; other site
653938006214	Na binding site 1 [ion binding]; other site
653938006215	putative substrate binding site 2 [chemical binding]; other site
653938006216	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
653938006217	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
653938006218	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
653938006219	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
653938006220	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
653938006221	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
653938006222	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
653938006223	purine monophosphate binding site [chemical binding]; other site
653938006224	dimer interface [polypeptide binding]; other site
653938006225	putative catalytic residues [active]
653938006226	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
653938006227	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
653938006228	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
653938006229	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
653938006230	active site
653938006231	substrate binding site [chemical binding]; other site
653938006232	cosubstrate binding site; other site
653938006233	catalytic site [active]
653938006234	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
653938006235	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
653938006236	dimerization interface [polypeptide binding]; other site
653938006237	putative ATP binding site [chemical binding]; other site
653938006238	amidophosphoribosyltransferase; Provisional; Region: PRK06781
653938006239	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
653938006240	active site
653938006241	tetramer interface [polypeptide binding]; other site
653938006242	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653938006243	active site
653938006244	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
653938006245	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
653938006246	dimerization interface [polypeptide binding]; other site
653938006247	ATP binding site [chemical binding]; other site
653938006248	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
653938006249	dimerization interface [polypeptide binding]; other site
653938006250	ATP binding site [chemical binding]; other site
653938006251	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
653938006252	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
653938006253	putative active site [active]
653938006254	catalytic triad [active]
653938006255	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
653938006256	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
653938006257	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
653938006258	ATP binding site [chemical binding]; other site
653938006259	active site
653938006260	substrate binding site [chemical binding]; other site
653938006261	adenylosuccinate lyase; Provisional; Region: PRK07492
653938006262	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
653938006263	tetramer interface [polypeptide binding]; other site
653938006264	active site
653938006265	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
653938006266	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
653938006267	NAD binding site [chemical binding]; other site
653938006268	ATP-grasp domain; Region: ATP-grasp; pfam02222
653938006269	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
653938006270	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
653938006271	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
653938006272	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
653938006273	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653938006274	Zn2+ binding site [ion binding]; other site
653938006275	Mg2+ binding site [ion binding]; other site
653938006276	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
653938006277	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938006278	Walker A/P-loop; other site
653938006279	ATP binding site [chemical binding]; other site
653938006280	Q-loop/lid; other site
653938006281	ABC transporter signature motif; other site
653938006282	Walker B; other site
653938006283	D-loop; other site
653938006284	H-loop/switch region; other site
653938006285	peptidase T; Region: peptidase-T; TIGR01882
653938006286	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
653938006287	metal binding site [ion binding]; metal-binding site
653938006288	dimer interface [polypeptide binding]; other site
653938006289	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
653938006290	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
653938006291	active site
653938006292	putative catalytic site [active]
653938006293	DNA binding site [nucleotide binding]
653938006294	putative phosphate binding site [ion binding]; other site
653938006295	metal binding site A [ion binding]; metal-binding site
653938006296	AP binding site [nucleotide binding]; other site
653938006297	metal binding site B [ion binding]; metal-binding site
653938006298	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
653938006299	23S rRNA binding site [nucleotide binding]; other site
653938006300	L21 binding site [polypeptide binding]; other site
653938006301	L13 binding site [polypeptide binding]; other site
653938006302	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
653938006303	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
653938006304	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
653938006305	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
653938006306	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
653938006307	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938006308	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
653938006309	Substrate binding site [chemical binding]; other site
653938006310	Leucine rich repeat; Region: LRR_8; pfam13855
653938006311	LRR adjacent; Region: LRR_adjacent; pfam08191
653938006312	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
653938006313	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
653938006314	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
653938006315	DNA binding residues [nucleotide binding]
653938006316	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
653938006317	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
653938006318	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
653938006319	Putative heavy-metal-binding; Region: YbjQ_1; pfam01906
653938006320	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
653938006321	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
653938006322	RimM N-terminal domain; Region: RimM; pfam01782
653938006323	PRC-barrel domain; Region: PRC; pfam05239
653938006324	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
653938006325	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
653938006326	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
653938006327	catalytic triad [active]
653938006328	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
653938006329	KH domain; Region: KH_4; pfam13083
653938006330	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
653938006331	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
653938006332	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
653938006333	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
653938006334	signal recognition particle protein; Provisional; Region: PRK10867
653938006335	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
653938006336	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
653938006337	P loop; other site
653938006338	GTP binding site [chemical binding]; other site
653938006339	Signal peptide binding domain; Region: SRP_SPB; pfam02978
653938006340	putative DNA-binding protein; Validated; Region: PRK00118
653938006341	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
653938006342	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
653938006343	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
653938006344	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
653938006345	P loop; other site
653938006346	GTP binding site [chemical binding]; other site
653938006347	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
653938006348	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
653938006349	Walker A/P-loop; other site
653938006350	ATP binding site [chemical binding]; other site
653938006351	Q-loop/lid; other site
653938006352	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
653938006353	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
653938006354	ABC transporter signature motif; other site
653938006355	Walker B; other site
653938006356	D-loop; other site
653938006357	H-loop/switch region; other site
653938006358	ribonuclease III; Reviewed; Region: rnc; PRK00102
653938006359	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
653938006360	dimerization interface [polypeptide binding]; other site
653938006361	active site
653938006362	metal binding site [ion binding]; metal-binding site
653938006363	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
653938006364	dsRNA binding site [nucleotide binding]; other site
653938006365	acyl carrier protein; Provisional; Region: acpP; PRK00982
653938006366	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
653938006367	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
653938006368	NAD(P) binding site [chemical binding]; other site
653938006369	homotetramer interface [polypeptide binding]; other site
653938006370	homodimer interface [polypeptide binding]; other site
653938006371	active site
653938006372	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
653938006373	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
653938006374	putative phosphate acyltransferase; Provisional; Region: PRK05331
653938006375	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
653938006376	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
653938006377	active site 2 [active]
653938006378	active site 1 [active]
653938006379	Y-family of DNA polymerases; Region: PolY; cl12025
653938006380	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
653938006381	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
653938006382	generic binding surface II; other site
653938006383	ssDNA binding site; other site
653938006384	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653938006385	ATP binding site [chemical binding]; other site
653938006386	putative Mg++ binding site [ion binding]; other site
653938006387	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653938006388	nucleotide binding region [chemical binding]; other site
653938006389	ATP-binding site [chemical binding]; other site
653938006390	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
653938006391	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
653938006392	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
653938006393	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
653938006394	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
653938006395	putative L-serine binding site [chemical binding]; other site
653938006396	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
653938006397	DAK2 domain; Region: Dak2; pfam02734
653938006398	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
653938006399	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
653938006400	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
653938006401	Thiamine pyrophosphokinase; Region: TPK; cd07995
653938006402	active site
653938006403	dimerization interface [polypeptide binding]; other site
653938006404	thiamine binding site [chemical binding]; other site
653938006405	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
653938006406	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
653938006407	substrate binding site [chemical binding]; other site
653938006408	hexamer interface [polypeptide binding]; other site
653938006409	metal binding site [ion binding]; metal-binding site
653938006410	GTPase RsgA; Reviewed; Region: PRK00098
653938006411	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
653938006412	RNA binding site [nucleotide binding]; other site
653938006413	homodimer interface [polypeptide binding]; other site
653938006414	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
653938006415	GTPase/Zn-binding domain interface [polypeptide binding]; other site
653938006416	GTP/Mg2+ binding site [chemical binding]; other site
653938006417	G4 box; other site
653938006418	G1 box; other site
653938006419	Switch I region; other site
653938006420	G2 box; other site
653938006421	G3 box; other site
653938006422	Switch II region; other site
653938006423	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
653938006424	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
653938006425	active site
653938006426	ATP binding site [chemical binding]; other site
653938006427	substrate binding site [chemical binding]; other site
653938006428	activation loop (A-loop); other site
653938006429	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
653938006430	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
653938006431	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
653938006432	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
653938006433	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
653938006434	Protein phosphatase 2C; Region: PP2C; pfam00481
653938006435	active site
653938006436	16S rRNA methyltransferase B; Provisional; Region: PRK14902
653938006437	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
653938006438	putative RNA binding site [nucleotide binding]; other site
653938006439	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938006440	S-adenosylmethionine binding site [chemical binding]; other site
653938006441	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
653938006442	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
653938006443	putative active site [active]
653938006444	substrate binding site [chemical binding]; other site
653938006445	putative cosubstrate binding site; other site
653938006446	catalytic site [active]
653938006447	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
653938006448	substrate binding site [chemical binding]; other site
653938006449	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
653938006450	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653938006451	ATP binding site [chemical binding]; other site
653938006452	putative Mg++ binding site [ion binding]; other site
653938006453	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653938006454	ATP-binding site [chemical binding]; other site
653938006455	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
653938006456	Flavoprotein; Region: Flavoprotein; pfam02441
653938006457	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
653938006458	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
653938006459	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
653938006460	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
653938006461	catalytic site [active]
653938006462	G-X2-G-X-G-K; other site
653938006463	Uncharacterized stress-induced protein [Function unknown]; Region: COG1561
653938006464	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
653938006465	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
653938006466	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
653938006467	Domain of unknown function (DUF814); Region: DUF814; pfam05670
653938006468	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
653938006469	putative NAD(P) binding site [chemical binding]; other site
653938006470	homodimer interface [polypeptide binding]; other site
653938006471	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653938006472	active site
653938006473	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
653938006474	active site
653938006475	dimer interface [polypeptide binding]; other site
653938006476	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
653938006477	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
653938006478	heterodimer interface [polypeptide binding]; other site
653938006479	active site
653938006480	FMN binding site [chemical binding]; other site
653938006481	homodimer interface [polypeptide binding]; other site
653938006482	substrate binding site [chemical binding]; other site
653938006483	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
653938006484	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
653938006485	FAD binding pocket [chemical binding]; other site
653938006486	FAD binding motif [chemical binding]; other site
653938006487	phosphate binding motif [ion binding]; other site
653938006488	beta-alpha-beta structure motif; other site
653938006489	NAD binding pocket [chemical binding]; other site
653938006490	Iron coordination center [ion binding]; other site
653938006491	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
653938006492	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
653938006493	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
653938006494	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
653938006495	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
653938006496	ATP-grasp domain; Region: ATP-grasp_4; cl17255
653938006497	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
653938006498	IMP binding site; other site
653938006499	dimer interface [polypeptide binding]; other site
653938006500	interdomain contacts; other site
653938006501	partial ornithine binding site; other site
653938006502	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
653938006503	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
653938006504	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
653938006505	catalytic site [active]
653938006506	subunit interface [polypeptide binding]; other site
653938006507	dihydroorotase; Validated; Region: pyrC; PRK09357
653938006508	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
653938006509	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
653938006510	active site
653938006511	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
653938006512	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
653938006513	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
653938006514	uracil transporter; Provisional; Region: PRK10720
653938006515	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
653938006516	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653938006517	active site
653938006518	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
653938006519	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
653938006520	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
653938006521	RNA binding surface [nucleotide binding]; other site
653938006522	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
653938006523	active site
653938006524	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
653938006525	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
653938006526	Sulfate transporter family; Region: Sulfate_transp; pfam00916
653938006527	multidrug efflux protein; Reviewed; Region: PRK01766
653938006528	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
653938006529	cation binding site [ion binding]; other site
653938006530	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
653938006531	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
653938006532	metal binding site [ion binding]; metal-binding site
653938006533	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
653938006534	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
653938006535	ABC-ATPase subunit  interface; other site
653938006536	dimer interface [polypeptide binding]; other site
653938006537	putative PBP binding regions; other site
653938006538	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
653938006539	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
653938006540	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
653938006541	MarR family; Region: MarR; pfam01047
653938006542	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
653938006543	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
653938006544	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
653938006545	protein binding site [polypeptide binding]; other site
653938006546	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
653938006547	Catalytic dyad [active]
653938006548	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
653938006549	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
653938006550	metal-binding site [ion binding]
653938006551	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
653938006552	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
653938006553	metal-binding site [ion binding]
653938006554	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
653938006555	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938006556	motif II; other site
653938006557	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
653938006558	putative homodimer interface [polypeptide binding]; other site
653938006559	putative homotetramer interface [polypeptide binding]; other site
653938006560	putative allosteric switch controlling residues; other site
653938006561	putative metal binding site [ion binding]; other site
653938006562	putative homodimer-homodimer interface [polypeptide binding]; other site
653938006563	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
653938006564	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
653938006565	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
653938006566	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
653938006567	hypothetical protein; Provisional; Region: PRK13672
653938006568	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
653938006569	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
653938006570	methionine sulfoxide reductase B; Provisional; Region: PRK00222
653938006571	SelR domain; Region: SelR; pfam01641
653938006572	methionine sulfoxide reductase A; Provisional; Region: PRK14054
653938006573	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548
653938006574	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
653938006575	active site
653938006576	catalytic triad [active]
653938006577	oxyanion hole [active]
653938006578	EDD domain protein, DegV family; Region: DegV; TIGR00762
653938006579	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
653938006580	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
653938006581	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
653938006582	HTH domain; Region: HTH_11; pfam08279
653938006583	FOG: CBS domain [General function prediction only]; Region: COG0517
653938006584	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
653938006585	PEP synthetase regulatory protein; Provisional; Region: PRK05339
653938006586	pyruvate phosphate dikinase; Provisional; Region: PRK09279
653938006587	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
653938006588	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
653938006589	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
653938006590	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
653938006591	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
653938006592	Predicted membrane protein [Function unknown]; Region: COG4129
653938006593	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
653938006594	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
653938006595	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
653938006596	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
653938006597	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
653938006598	active site
653938006599	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
653938006600	substrate binding site [chemical binding]; other site
653938006601	metal binding site [ion binding]; metal-binding site
653938006602	Methyltransferase domain; Region: Methyltransf_23; pfam13489
653938006603	Methyltransferase domain; Region: Methyltransf_18; pfam12847
653938006604	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
653938006605	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
653938006606	folate binding site [chemical binding]; other site
653938006607	NADP+ binding site [chemical binding]; other site
653938006608	thymidylate synthase; Region: thym_sym; TIGR03284
653938006609	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
653938006610	dimerization interface [polypeptide binding]; other site
653938006611	active site
653938006612	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
653938006613	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938006614	Walker A/P-loop; other site
653938006615	ATP binding site [chemical binding]; other site
653938006616	Q-loop/lid; other site
653938006617	ABC transporter signature motif; other site
653938006618	Walker B; other site
653938006619	D-loop; other site
653938006620	H-loop/switch region; other site
653938006621	ABC transporter; Region: ABC_tran_2; pfam12848
653938006622	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653938006623	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
653938006624	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
653938006625	Potassium binding sites [ion binding]; other site
653938006626	Cesium cation binding sites [ion binding]; other site
653938006627	manganese transport transcriptional regulator; Provisional; Region: PRK03902
653938006628	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
653938006629	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
653938006630	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
653938006631	DNA-binding site [nucleotide binding]; DNA binding site
653938006632	RNA-binding motif; other site
653938006633	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
653938006634	RNA/DNA hybrid binding site [nucleotide binding]; other site
653938006635	active site
653938006636	5'-3' exonuclease; Region: 53EXOc; smart00475
653938006637	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
653938006638	active site
653938006639	metal binding site 1 [ion binding]; metal-binding site
653938006640	putative 5' ssDNA interaction site; other site
653938006641	metal binding site 3; metal-binding site
653938006642	metal binding site 2 [ion binding]; metal-binding site
653938006643	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
653938006644	putative DNA binding site [nucleotide binding]; other site
653938006645	putative metal binding site [ion binding]; other site
653938006646	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
653938006647	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
653938006648	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
653938006649	putative active site [active]
653938006650	xanthine permease; Region: pbuX; TIGR03173
653938006651	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653938006652	active site
653938006653	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
653938006654	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
653938006655	active site
653938006656	Zn binding site [ion binding]; other site
653938006657	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
653938006658	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
653938006659	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
653938006660	cell division protein GpsB; Provisional; Region: PRK14127
653938006661	DivIVA domain; Region: DivI1A_domain; TIGR03544
653938006662	Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884
653938006663	hypothetical protein; Provisional; Region: PRK13660
653938006664	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
653938006665	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
653938006666	Transglycosylase; Region: Transgly; pfam00912
653938006667	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
653938006668	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
653938006669	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
653938006670	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
653938006671	minor groove reading motif; other site
653938006672	helix-hairpin-helix signature motif; other site
653938006673	substrate binding pocket [chemical binding]; other site
653938006674	active site
653938006675	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
653938006676	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
653938006677	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
653938006678	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
653938006679	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
653938006680	putative dimer interface [polypeptide binding]; other site
653938006681	putative anticodon binding site; other site
653938006682	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
653938006683	homodimer interface [polypeptide binding]; other site
653938006684	motif 1; other site
653938006685	motif 2; other site
653938006686	active site
653938006687	motif 3; other site
653938006688	aspartate aminotransferase; Provisional; Region: PRK05764
653938006689	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
653938006690	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938006691	homodimer interface [polypeptide binding]; other site
653938006692	catalytic residue [active]
653938006693	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
653938006694	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
653938006695	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
653938006696	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
653938006697	active site
653938006698	catalytic site [active]
653938006699	substrate binding site [chemical binding]; other site
653938006700	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
653938006701	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
653938006702	putative Mg++ binding site [ion binding]; other site
653938006703	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
653938006704	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
653938006705	tetramerization interface [polypeptide binding]; other site
653938006706	active site
653938006707	pantoate--beta-alanine ligase; Region: panC; TIGR00018
653938006708	Pantoate-beta-alanine ligase; Region: PanC; cd00560
653938006709	active site
653938006710	ATP-binding site [chemical binding]; other site
653938006711	pantoate-binding site; other site
653938006712	HXXH motif; other site
653938006713	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
653938006714	active site
653938006715	oligomerization interface [polypeptide binding]; other site
653938006716	metal binding site [ion binding]; metal-binding site
653938006717	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
653938006718	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
653938006719	catalytic residues [active]
653938006720	Biotin operon repressor [Transcription]; Region: BirA; COG1654
653938006721	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
653938006722	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
653938006723	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
653938006724	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
653938006725	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
653938006726	active site
653938006727	NTP binding site [chemical binding]; other site
653938006728	metal binding triad [ion binding]; metal-binding site
653938006729	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
653938006730	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
653938006731	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
653938006732	active site
653938006733	dimer interfaces [polypeptide binding]; other site
653938006734	catalytic residues [active]
653938006735	dihydrodipicolinate reductase; Provisional; Region: PRK00048
653938006736	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
653938006737	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
653938006738	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
653938006739	homodimer interface [polypeptide binding]; other site
653938006740	metal binding site [ion binding]; metal-binding site
653938006741	Uncharacterized conserved protein [Function unknown]; Region: COG1284
653938006742	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
653938006743	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
653938006744	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
653938006745	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
653938006746	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653938006747	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653938006748	metal binding site [ion binding]; metal-binding site
653938006749	active site
653938006750	I-site; other site
653938006751	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
653938006752	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653938006753	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653938006754	metal binding site [ion binding]; metal-binding site
653938006755	active site
653938006756	I-site; other site
653938006757	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
653938006758	malate dehydrogenase; Provisional; Region: PRK13529
653938006759	Malic enzyme, N-terminal domain; Region: malic; pfam00390
653938006760	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
653938006761	NAD(P) binding pocket [chemical binding]; other site
653938006762	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
653938006763	Beta-lactamase; Region: Beta-lactamase; pfam00144
653938006764	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
653938006765	Pyruvate formate lyase 1; Region: PFL1; cd01678
653938006766	coenzyme A binding site [chemical binding]; other site
653938006767	active site
653938006768	catalytic residues [active]
653938006769	glycine loop; other site
653938006770	HI0933-like protein; Region: HI0933_like; pfam03486
653938006771	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
653938006772	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
653938006773	Predicted membrane protein [Function unknown]; Region: COG4347
653938006774	hypothetical protein; Provisional; Region: PRK03636
653938006775	UPF0302 domain; Region: UPF0302; pfam08864
653938006776	IDEAL domain; Region: IDEAL; pfam08858
653938006777	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
653938006778	binding surface
653938006779	TPR motif; other site
653938006780	TPR repeat; Region: TPR_11; pfam13414
653938006781	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653938006782	binding surface
653938006783	TPR motif; other site
653938006784	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
653938006785	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
653938006786	hinge; other site
653938006787	active site
653938006788	prephenate dehydrogenase; Validated; Region: PRK06545
653938006789	prephenate dehydrogenase; Validated; Region: PRK08507
653938006790	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
653938006791	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
653938006792	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
653938006793	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938006794	homodimer interface [polypeptide binding]; other site
653938006795	catalytic residue [active]
653938006796	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
653938006797	homotrimer interaction site [polypeptide binding]; other site
653938006798	active site
653938006799	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
653938006800	active site
653938006801	dimer interface [polypeptide binding]; other site
653938006802	metal binding site [ion binding]; metal-binding site
653938006803	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
653938006804	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
653938006805	Tetramer interface [polypeptide binding]; other site
653938006806	active site
653938006807	FMN-binding site [chemical binding]; other site
653938006808	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
653938006809	active site
653938006810	multimer interface [polypeptide binding]; other site
653938006811	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
653938006812	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
653938006813	substrate binding pocket [chemical binding]; other site
653938006814	chain length determination region; other site
653938006815	substrate-Mg2+ binding site; other site
653938006816	catalytic residues [active]
653938006817	aspartate-rich region 1; other site
653938006818	active site lid residues [active]
653938006819	aspartate-rich region 2; other site
653938006820	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
653938006821	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938006822	S-adenosylmethionine binding site [chemical binding]; other site
653938006823	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
653938006824	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
653938006825	homodecamer interface [polypeptide binding]; other site
653938006826	GTP cyclohydrolase I; Provisional; Region: PLN03044
653938006827	active site
653938006828	putative catalytic site residues [active]
653938006829	zinc binding site [ion binding]; other site
653938006830	GTP-CH-I/GFRP interaction surface; other site
653938006831	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
653938006832	IHF dimer interface [polypeptide binding]; other site
653938006833	IHF - DNA interface [nucleotide binding]; other site
653938006834	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
653938006835	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
653938006836	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
653938006837	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
653938006838	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
653938006839	GTP-binding protein Der; Reviewed; Region: PRK00093
653938006840	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
653938006841	G1 box; other site
653938006842	GTP/Mg2+ binding site [chemical binding]; other site
653938006843	Switch I region; other site
653938006844	G2 box; other site
653938006845	Switch II region; other site
653938006846	G3 box; other site
653938006847	G4 box; other site
653938006848	G5 box; other site
653938006849	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
653938006850	G1 box; other site
653938006851	GTP/Mg2+ binding site [chemical binding]; other site
653938006852	Switch I region; other site
653938006853	G2 box; other site
653938006854	G3 box; other site
653938006855	Switch II region; other site
653938006856	G4 box; other site
653938006857	G5 box; other site
653938006858	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
653938006859	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
653938006860	RNA binding site [nucleotide binding]; other site
653938006861	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
653938006862	RNA binding site [nucleotide binding]; other site
653938006863	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
653938006864	RNA binding site [nucleotide binding]; other site
653938006865	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
653938006866	RNA binding site [nucleotide binding]; other site
653938006867	cytidylate kinase; Provisional; Region: cmk; PRK00023
653938006868	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
653938006869	CMP-binding site; other site
653938006870	The sites determining sugar specificity; other site
653938006871	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
653938006872	active site
653938006873	homotetramer interface [polypeptide binding]; other site
653938006874	homodimer interface [polypeptide binding]; other site
653938006875	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653938006876	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
653938006877	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
653938006878	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653938006879	ATP binding site [chemical binding]; other site
653938006880	putative Mg++ binding site [ion binding]; other site
653938006881	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653938006882	nucleotide binding region [chemical binding]; other site
653938006883	ATP-binding site [chemical binding]; other site
653938006884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
653938006885	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
653938006886	Predicted membrane protein [Function unknown]; Region: COG3601
653938006887	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
653938006888	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
653938006889	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653938006890	dimerization interface [polypeptide binding]; other site
653938006891	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
653938006892	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653938006893	dimer interface [polypeptide binding]; other site
653938006894	phosphorylation site [posttranslational modification]
653938006895	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938006896	ATP binding site [chemical binding]; other site
653938006897	Mg2+ binding site [ion binding]; other site
653938006898	G-X-G motif; other site
653938006899	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
653938006900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938006901	active site
653938006902	phosphorylation site [posttranslational modification]
653938006903	intermolecular recognition site; other site
653938006904	dimerization interface [polypeptide binding]; other site
653938006905	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
653938006906	DNA binding site [nucleotide binding]
653938006907	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
653938006908	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
653938006909	RNA binding surface [nucleotide binding]; other site
653938006910	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
653938006911	active site
653938006912	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
653938006913	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
653938006914	diaminopimelate decarboxylase; Region: lysA; TIGR01048
653938006915	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
653938006916	active site
653938006917	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
653938006918	substrate binding site [chemical binding]; other site
653938006919	catalytic residues [active]
653938006920	dimer interface [polypeptide binding]; other site
653938006921	purine nucleoside phosphorylase; Provisional; Region: PRK08202
653938006922	phosphopentomutase; Provisional; Region: PRK05362
653938006923	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
653938006924	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
653938006925	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
653938006926	active site
653938006927	Int/Topo IB signature motif; other site
653938006928	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
653938006929	metal binding site 2 [ion binding]; metal-binding site
653938006930	putative DNA binding helix; other site
653938006931	metal binding site 1 [ion binding]; metal-binding site
653938006932	dimer interface [polypeptide binding]; other site
653938006933	structural Zn2+ binding site [ion binding]; other site
653938006934	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
653938006935	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
653938006936	ABC-ATPase subunit  interface; other site
653938006937	dimer interface [polypeptide binding]; other site
653938006938	putative PBP binding regions; other site
653938006939	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
653938006940	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
653938006941	ABC-ATPase subunit  interface; other site
653938006942	dimer interface [polypeptide binding]; other site
653938006943	putative PBP binding regions; other site
653938006944	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
653938006945	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
653938006946	putative ligand binding residues [chemical binding]; other site
653938006947	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
653938006948	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
653938006949	Walker A/P-loop; other site
653938006950	ATP binding site [chemical binding]; other site
653938006951	Q-loop/lid; other site
653938006952	ABC transporter signature motif; other site
653938006953	Walker B; other site
653938006954	D-loop; other site
653938006955	H-loop/switch region; other site
653938006956	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
653938006957	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
653938006958	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
653938006959	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
653938006960	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
653938006961	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
653938006962	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
653938006963	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
653938006964	Walker A/P-loop; other site
653938006965	ATP binding site [chemical binding]; other site
653938006966	Q-loop/lid; other site
653938006967	ABC transporter signature motif; other site
653938006968	Walker B; other site
653938006969	D-loop; other site
653938006970	H-loop/switch region; other site
653938006971	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
653938006972	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
653938006973	dimer interface [polypeptide binding]; other site
653938006974	ADP-ribose binding site [chemical binding]; other site
653938006975	active site
653938006976	nudix motif; other site
653938006977	metal binding site [ion binding]; metal-binding site
653938006978	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
653938006979	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
653938006980	Creatinine amidohydrolase; Region: Creatininase; pfam02633
653938006981	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
653938006982	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
653938006983	active site
653938006984	intersubunit interface [polypeptide binding]; other site
653938006985	catalytic residue [active]
653938006986	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
653938006987	active site
653938006988	substrate binding pocket [chemical binding]; other site
653938006989	homodimer interaction site [polypeptide binding]; other site
653938006990	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
653938006991	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
653938006992	active site
653938006993	P-loop; other site
653938006994	phosphorylation site [posttranslational modification]
653938006995	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938006996	active site
653938006997	phosphorylation site [posttranslational modification]
653938006998	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
653938006999	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938007000	DNA-binding site [nucleotide binding]; DNA binding site
653938007001	UTRA domain; Region: UTRA; pfam07702
653938007002	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
653938007003	active site
653938007004	DNA polymerase IV; Validated; Region: PRK02406
653938007005	DNA binding site [nucleotide binding]
653938007006	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
653938007007	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
653938007008	NAD(P) binding site [chemical binding]; other site
653938007009	active site
653938007010	ribonuclease Z; Region: RNase_Z; TIGR02651
653938007011	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
653938007012	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
653938007013	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
653938007014	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
653938007015	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
653938007016	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938007017	Coenzyme A binding pocket [chemical binding]; other site
653938007018	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
653938007019	6-phosphogluconate dehydratase; Region: edd; TIGR01196
653938007020	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
653938007021	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
653938007022	PYR/PP interface [polypeptide binding]; other site
653938007023	dimer interface [polypeptide binding]; other site
653938007024	TPP binding site [chemical binding]; other site
653938007025	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
653938007026	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
653938007027	TPP-binding site [chemical binding]; other site
653938007028	dimer interface [polypeptide binding]; other site
653938007029	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
653938007030	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
653938007031	putative valine binding site [chemical binding]; other site
653938007032	dimer interface [polypeptide binding]; other site
653938007033	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
653938007034	ketol-acid reductoisomerase; Provisional; Region: PRK05479
653938007035	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
653938007036	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
653938007037	2-isopropylmalate synthase; Validated; Region: PRK00915
653938007038	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
653938007039	active site
653938007040	catalytic residues [active]
653938007041	metal binding site [ion binding]; metal-binding site
653938007042	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
653938007043	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
653938007044	tartrate dehydrogenase; Region: TTC; TIGR02089
653938007045	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
653938007046	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
653938007047	substrate binding site [chemical binding]; other site
653938007048	ligand binding site [chemical binding]; other site
653938007049	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
653938007050	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
653938007051	substrate binding site [chemical binding]; other site
653938007052	threonine dehydratase; Validated; Region: PRK08639
653938007053	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
653938007054	tetramer interface [polypeptide binding]; other site
653938007055	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938007056	catalytic residue [active]
653938007057	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
653938007058	alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252
653938007059	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
653938007060	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
653938007061	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
653938007062	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
653938007063	Transcriptional regulators [Transcription]; Region: PurR; COG1609
653938007064	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
653938007065	DNA binding site [nucleotide binding]
653938007066	domain linker motif; other site
653938007067	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
653938007068	dimerization interface [polypeptide binding]; other site
653938007069	ligand binding site [chemical binding]; other site
653938007070	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
653938007071	intersubunit interface [polypeptide binding]; other site
653938007072	active site
653938007073	catalytic residue [active]
653938007074	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
653938007075	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
653938007076	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
653938007077	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
653938007078	active pocket/dimerization site; other site
653938007079	active site
653938007080	phosphorylation site [posttranslational modification]
653938007081	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
653938007082	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
653938007083	putative active site [active]
653938007084	SIS domain; Region: SIS; pfam01380
653938007085	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
653938007086	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
653938007087	dimer interface [polypeptide binding]; other site
653938007088	active site
653938007089	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
653938007090	dimer interface [polypeptide binding]; other site
653938007091	active site
653938007092	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
653938007093	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
653938007094	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
653938007095	active site
653938007096	phosphorylation site [posttranslational modification]
653938007097	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
653938007098	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938007099	DNA-binding site [nucleotide binding]; DNA binding site
653938007100	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
653938007101	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
653938007102	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938007103	DNA-binding site [nucleotide binding]; DNA binding site
653938007104	UTRA domain; Region: UTRA; pfam07702
653938007105	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
653938007106	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
653938007107	active site
653938007108	catalytic tetrad [active]
653938007109	acetolactate synthase; Reviewed; Region: PRK08617
653938007110	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
653938007111	PYR/PP interface [polypeptide binding]; other site
653938007112	dimer interface [polypeptide binding]; other site
653938007113	TPP binding site [chemical binding]; other site
653938007114	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
653938007115	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
653938007116	TPP-binding site [chemical binding]; other site
653938007117	dimer interface [polypeptide binding]; other site
653938007118	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
653938007119	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
653938007120	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
653938007121	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
653938007122	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938007123	dimer interface [polypeptide binding]; other site
653938007124	conserved gate region; other site
653938007125	ABC-ATPase subunit interface; other site
653938007126	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
653938007127	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938007128	dimer interface [polypeptide binding]; other site
653938007129	conserved gate region; other site
653938007130	ABC-ATPase subunit interface; other site
653938007131	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
653938007132	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938007133	active site
653938007134	phosphorylation site [posttranslational modification]
653938007135	intermolecular recognition site; other site
653938007136	dimerization interface [polypeptide binding]; other site
653938007137	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
653938007138	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
653938007139	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653938007140	dimerization interface [polypeptide binding]; other site
653938007141	Histidine kinase; Region: His_kinase; pfam06580
653938007142	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938007143	ATP binding site [chemical binding]; other site
653938007144	Mg2+ binding site [ion binding]; other site
653938007145	G-X-G motif; other site
653938007146	Predicted integral membrane protein [Function unknown]; Region: COG5578
653938007147	Uncharacterized conserved protein [Function unknown]; Region: COG3538
653938007148	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
653938007149	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
653938007150	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
653938007151	active site
653938007152	metal binding site [ion binding]; metal-binding site
653938007153	homodimer interface [polypeptide binding]; other site
653938007154	catalytic site [active]
653938007155	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
653938007156	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
653938007157	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
653938007158	active site
653938007159	catalytic site [active]
653938007160	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
653938007161	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
653938007162	DNA-binding site [nucleotide binding]; DNA binding site
653938007163	RNA-binding motif; other site
653938007164	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
653938007165	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
653938007166	active site
653938007167	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
653938007168	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
653938007169	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
653938007170	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
653938007171	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
653938007172	HIGH motif; other site
653938007173	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
653938007174	active site
653938007175	KMSKS motif; other site
653938007176	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
653938007177	tRNA binding surface [nucleotide binding]; other site
653938007178	anticodon binding site; other site
653938007179	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
653938007180	DivIVA protein; Region: DivIVA; pfam05103
653938007181	DivIVA domain; Region: DivI1A_domain; TIGR03544
653938007182	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
653938007183	HTH domain; Region: HTH_11; pfam08279
653938007184	3H domain; Region: 3H; pfam02829
653938007185	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
653938007186	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
653938007187	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
653938007188	catalytic residue [active]
653938007189	L-aspartate oxidase; Provisional; Region: PRK08071
653938007190	L-aspartate oxidase; Provisional; Region: PRK06175
653938007191	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
653938007192	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
653938007193	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
653938007194	dimerization interface [polypeptide binding]; other site
653938007195	active site
653938007196	quinolinate synthetase; Provisional; Region: PRK09375
653938007197	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
653938007198	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
653938007199	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
653938007200	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
653938007201	RNA binding surface [nucleotide binding]; other site
653938007202	YGGT family; Region: YGGT; pfam02325
653938007203	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
653938007204	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
653938007205	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
653938007206	catalytic residue [active]
653938007207	cell division protein FtsZ; Validated; Region: PRK09330
653938007208	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
653938007209	nucleotide binding site [chemical binding]; other site
653938007210	SulA interaction site; other site
653938007211	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
653938007212	Cell division protein FtsA; Region: FtsA; smart00842
653938007213	Cell division protein FtsA; Region: FtsA; pfam14450
653938007214	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
653938007215	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
653938007216	Cell division protein FtsQ; Region: FtsQ; pfam03799
653938007217	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
653938007218	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
653938007219	active site
653938007220	homodimer interface [polypeptide binding]; other site
653938007221	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
653938007222	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
653938007223	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
653938007224	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
653938007225	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
653938007226	Mg++ binding site [ion binding]; other site
653938007227	putative catalytic motif [active]
653938007228	putative substrate binding site [chemical binding]; other site
653938007229	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
653938007230	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
653938007231	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
653938007232	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
653938007233	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
653938007234	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
653938007235	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
653938007236	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
653938007237	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
653938007238	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
653938007239	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
653938007240	MraW methylase family; Region: Methyltransf_5; pfam01795
653938007241	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
653938007242	MraZ protein; Region: MraZ; pfam02381
653938007243	MraZ protein; Region: MraZ; pfam02381
653938007244	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653938007245	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938007246	putative substrate translocation pore; other site
653938007247	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
653938007248	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
653938007249	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
653938007250	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
653938007251	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
653938007252	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
653938007253	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
653938007254	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
653938007255	hypothetical protein; Provisional; Region: PRK13670
653938007256	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
653938007257	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
653938007258	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
653938007259	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938007260	Walker A/P-loop; other site
653938007261	ATP binding site [chemical binding]; other site
653938007262	Q-loop/lid; other site
653938007263	ABC transporter signature motif; other site
653938007264	Walker B; other site
653938007265	D-loop; other site
653938007266	H-loop/switch region; other site
653938007267	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
653938007268	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
653938007269	protein binding site [polypeptide binding]; other site
653938007270	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
653938007271	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
653938007272	active site
653938007273	(T/H)XGH motif; other site
653938007274	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
653938007275	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938007276	S-adenosylmethionine binding site [chemical binding]; other site
653938007277	hypothetical protein; Provisional; Region: PRK02886
653938007278	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
653938007279	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
653938007280	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
653938007281	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
653938007282	UbiA prenyltransferase family; Region: UbiA; pfam01040
653938007283	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
653938007284	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
653938007285	Ion transport protein; Region: Ion_trans; pfam00520
653938007286	Ion channel; Region: Ion_trans_2; pfam07885
653938007287	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
653938007288	MOSC domain; Region: MOSC; pfam03473
653938007289	3-alpha domain; Region: 3-alpha; pfam03475
653938007290	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
653938007291	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
653938007292	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
653938007293	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953
653938007294	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
653938007295	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
653938007296	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
653938007297	active site
653938007298	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
653938007299	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
653938007300	ring oligomerisation interface [polypeptide binding]; other site
653938007301	ATP/Mg binding site [chemical binding]; other site
653938007302	stacking interactions; other site
653938007303	hinge regions; other site
653938007304	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
653938007305	oligomerisation interface [polypeptide binding]; other site
653938007306	mobile loop; other site
653938007307	roof hairpin; other site
653938007308	CAAX protease self-immunity; Region: Abi; pfam02517
653938007309	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
653938007310	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
653938007311	CoA binding domain; Region: CoA_binding; pfam02629
653938007312	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
653938007313	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653938007314	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653938007315	ABC transporter; Region: ABC_tran_2; pfam12848
653938007316	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653938007317	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
653938007318	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
653938007319	UGMP family protein; Validated; Region: PRK09604
653938007320	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
653938007321	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
653938007322	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938007323	Coenzyme A binding pocket [chemical binding]; other site
653938007324	Glycoprotease family; Region: Peptidase_M22; pfam00814
653938007325	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
653938007326	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
653938007327	camphor resistance protein CrcB; Provisional; Region: PRK14214
653938007328	camphor resistance protein CrcB; Provisional; Region: PRK14231
653938007329	Uncharacterized conserved protein [Function unknown]; Region: COG4832
653938007330	Phosphotransferase enzyme family; Region: APH; pfam01636
653938007331	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
653938007332	active site
653938007333	substrate binding site [chemical binding]; other site
653938007334	ATP binding site [chemical binding]; other site
653938007335	Cna protein B-type domain; Region: Cna_B; pfam05738
653938007336	Cna protein B-type domain; Region: Cna_B; pfam05738
653938007337	Cna protein B-type domain; Region: Cna_B; pfam05738
653938007338	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
653938007339	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938007340	non-specific DNA binding site [nucleotide binding]; other site
653938007341	salt bridge; other site
653938007342	sequence-specific DNA binding site [nucleotide binding]; other site
653938007343	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
653938007344	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
653938007345	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
653938007346	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
653938007347	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
653938007348	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
653938007349	substrate binding pocket [chemical binding]; other site
653938007350	argininosuccinate synthase; Provisional; Region: PRK13820
653938007351	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
653938007352	ANP binding site [chemical binding]; other site
653938007353	Substrate Binding Site II [chemical binding]; other site
653938007354	Substrate Binding Site I [chemical binding]; other site
653938007355	argininosuccinate lyase; Provisional; Region: PRK00855
653938007356	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
653938007357	active sites [active]
653938007358	tetramer interface [polypeptide binding]; other site
653938007359	BCCT family transporter; Region: BCCT; pfam02028
653938007360	hypothetical protein; Provisional; Region: PRK06357
653938007361	active site
653938007362	intersubunit interface [polypeptide binding]; other site
653938007363	Zn2+ binding site [ion binding]; other site
653938007364	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
653938007365	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
653938007366	putative substrate binding site [chemical binding]; other site
653938007367	putative ATP binding site [chemical binding]; other site
653938007368	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
653938007369	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
653938007370	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
653938007371	active site
653938007372	P-loop; other site
653938007373	phosphorylation site [posttranslational modification]
653938007374	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938007375	active site
653938007376	phosphorylation site [posttranslational modification]
653938007377	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
653938007378	PRD domain; Region: PRD; pfam00874
653938007379	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
653938007380	active site
653938007381	P-loop; other site
653938007382	phosphorylation site [posttranslational modification]
653938007383	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762
653938007384	active site
653938007385	phosphorylation site [posttranslational modification]
653938007386	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
653938007387	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938007388	DNA-binding site [nucleotide binding]; DNA binding site
653938007389	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
653938007390	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938007391	homodimer interface [polypeptide binding]; other site
653938007392	catalytic residue [active]
653938007393	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
653938007394	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
653938007395	active site
653938007396	multimer interface [polypeptide binding]; other site
653938007397	glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525
653938007398	conserved cys residue [active]
653938007399	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
653938007400	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
653938007401	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
653938007402	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
653938007403	G1 box; other site
653938007404	GTP/Mg2+ binding site [chemical binding]; other site
653938007405	Switch I region; other site
653938007406	G2 box; other site
653938007407	G3 box; other site
653938007408	Switch II region; other site
653938007409	G4 box; other site
653938007410	G5 box; other site
653938007411	Nucleoside recognition; Region: Gate; pfam07670
653938007412	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
653938007413	Nucleoside recognition; Region: Gate; pfam07670
653938007414	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
653938007415	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
653938007416	putative active site [active]
653938007417	putative metal binding site [ion binding]; other site
653938007418	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
653938007419	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
653938007420	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
653938007421	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
653938007422	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
653938007423	active site
653938007424	dimer interface [polypeptide binding]; other site
653938007425	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
653938007426	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
653938007427	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
653938007428	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
653938007429	dimer interface [polypeptide binding]; other site
653938007430	FMN binding site [chemical binding]; other site
653938007431	NADPH bind site [chemical binding]; other site
653938007432	Helix-turn-helix domain; Region: HTH_17; pfam12728
653938007433	putative heme peroxidase; Provisional; Region: PRK12276
653938007434	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
653938007435	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653938007436	Walker A/P-loop; other site
653938007437	ATP binding site [chemical binding]; other site
653938007438	Q-loop/lid; other site
653938007439	ABC transporter signature motif; other site
653938007440	Walker B; other site
653938007441	D-loop; other site
653938007442	H-loop/switch region; other site
653938007443	FtsX-like permease family; Region: FtsX; pfam02687
653938007444	FtsX-like permease family; Region: FtsX; pfam02687
653938007445	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938007446	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
653938007447	Coenzyme A binding pocket [chemical binding]; other site
653938007448	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
653938007449	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
653938007450	active site
653938007451	substrate binding site [chemical binding]; other site
653938007452	metal binding site [ion binding]; metal-binding site
653938007453	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
653938007454	YbbR-like protein; Region: YbbR; pfam07949
653938007455	YbbR-like protein; Region: YbbR; pfam07949
653938007456	YbbR-like protein; Region: YbbR; pfam07949
653938007457	Uncharacterized conserved protein [Function unknown]; Region: COG1624
653938007458	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
653938007459	maltose phosphorylase; Provisional; Region: PRK13807
653938007460	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
653938007461	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
653938007462	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
653938007463	Predicted integral membrane protein [Function unknown]; Region: COG5521
653938007464	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
653938007465	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938007466	dimer interface [polypeptide binding]; other site
653938007467	conserved gate region; other site
653938007468	putative PBP binding loops; other site
653938007469	ABC-ATPase subunit interface; other site
653938007470	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938007471	dimer interface [polypeptide binding]; other site
653938007472	conserved gate region; other site
653938007473	putative PBP binding loops; other site
653938007474	ABC-ATPase subunit interface; other site
653938007475	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
653938007476	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
653938007477	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
653938007478	homodimer interface [polypeptide binding]; other site
653938007479	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
653938007480	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
653938007481	active site
653938007482	homodimer interface [polypeptide binding]; other site
653938007483	catalytic site [active]
653938007484	CAAX protease self-immunity; Region: Abi; cl00558
653938007485	Transcriptional regulators [Transcription]; Region: PurR; COG1609
653938007486	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
653938007487	DNA binding site [nucleotide binding]
653938007488	domain linker motif; other site
653938007489	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
653938007490	ligand binding site [chemical binding]; other site
653938007491	dimerization interface [polypeptide binding]; other site
653938007492	Amino acid permease; Region: AA_permease_2; pfam13520
653938007493	K+ potassium transporter; Region: K_trans; cl15781
653938007494	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938007495	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
653938007496	ligand binding site [chemical binding]; other site
653938007497	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938007498	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
653938007499	ligand binding site [chemical binding]; other site
653938007500	flexible hinge region; other site
653938007501	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
653938007502	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
653938007503	intersubunit interface [polypeptide binding]; other site
653938007504	active site
653938007505	zinc binding site [ion binding]; other site
653938007506	Na+ binding site [ion binding]; other site
653938007507	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
653938007508	intersubunit interface [polypeptide binding]; other site
653938007509	active site
653938007510	zinc binding site [ion binding]; other site
653938007511	Na+ binding site [ion binding]; other site
653938007512	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
653938007513	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
653938007514	active site
653938007515	P-loop; other site
653938007516	phosphorylation site [posttranslational modification]
653938007517	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938007518	active site
653938007519	phosphorylation site [posttranslational modification]
653938007520	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
653938007521	HTH domain; Region: HTH_11; pfam08279
653938007522	Mga helix-turn-helix domain; Region: Mga; pfam05043
653938007523	PRD domain; Region: PRD; pfam00874
653938007524	PRD domain; Region: PRD; pfam00874
653938007525	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
653938007526	active site
653938007527	P-loop; other site
653938007528	phosphorylation site [posttranslational modification]
653938007529	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
653938007530	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938007531	Walker A/P-loop; other site
653938007532	ATP binding site [chemical binding]; other site
653938007533	Q-loop/lid; other site
653938007534	ABC transporter signature motif; other site
653938007535	Walker B; other site
653938007536	D-loop; other site
653938007537	H-loop/switch region; other site
653938007538	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
653938007539	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
653938007540	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
653938007541	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938007542	Coenzyme A binding pocket [chemical binding]; other site
653938007543	Transcriptional regulators [Transcription]; Region: GntR; COG1802
653938007544	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
653938007545	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
653938007546	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
653938007547	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938007548	DNA-binding site [nucleotide binding]; DNA binding site
653938007549	UTRA domain; Region: UTRA; pfam07702
653938007550	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
653938007551	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
653938007552	Transcriptional regulator [Transcription]; Region: LysR; COG0583
653938007553	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
653938007554	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
653938007555	putative dimerization interface [polypeptide binding]; other site
653938007556	Predicted membrane protein [Function unknown]; Region: COG2855
653938007557	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
653938007558	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
653938007559	putative metal binding site [ion binding]; other site
653938007560	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
653938007561	metal binding site [ion binding]; metal-binding site
653938007562	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
653938007563	catalytic residues [active]
653938007564	flavodoxin; Provisional; Region: PRK09271
653938007565	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
653938007566	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
653938007567	dimer interface [polypeptide binding]; other site
653938007568	putative radical transfer pathway; other site
653938007569	diiron center [ion binding]; other site
653938007570	tyrosyl radical; other site
653938007571	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209
653938007572	Class I ribonucleotide reductase; Region: RNR_I; cd01679
653938007573	active site
653938007574	dimer interface [polypeptide binding]; other site
653938007575	catalytic residues [active]
653938007576	effector binding site; other site
653938007577	R2 peptide binding site; other site
653938007578	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
653938007579	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
653938007580	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
653938007581	CsbD-like; Region: CsbD; cl17424
653938007582	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
653938007583	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
653938007584	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
653938007585	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
653938007586	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
653938007587	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
653938007588	conserved cys residue [active]
653938007589	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
653938007590	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
653938007591	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
653938007592	Cupin domain; Region: Cupin_2; cl17218
653938007593	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
653938007594	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
653938007595	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938007596	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
653938007597	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938007598	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
653938007599	ligand binding site [chemical binding]; other site
653938007600	flexible hinge region; other site
653938007601	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
653938007602	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
653938007603	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
653938007604	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
653938007605	dimer interface [polypeptide binding]; other site
653938007606	active site
653938007607	metal binding site [ion binding]; metal-binding site
653938007608	glutathione binding site [chemical binding]; other site
653938007609	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
653938007610	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
653938007611	FMN binding site [chemical binding]; other site
653938007612	substrate binding site [chemical binding]; other site
653938007613	putative catalytic residue [active]
653938007614	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
653938007615	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
653938007616	Coenzyme A transferase; Region: CoA_trans; smart00882
653938007617	Coenzyme A transferase; Region: CoA_trans; cl17247
653938007618	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938007619	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
653938007620	Walker A motif; other site
653938007621	ATP binding site [chemical binding]; other site
653938007622	Walker B motif; other site
653938007623	arginine finger; other site
653938007624	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
653938007625	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
653938007626	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653938007627	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653938007628	metal binding site [ion binding]; metal-binding site
653938007629	active site
653938007630	I-site; other site
653938007631	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
653938007632	classical (c) SDRs; Region: SDR_c; cd05233
653938007633	NAD(P) binding site [chemical binding]; other site
653938007634	active site
653938007635	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
653938007636	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
653938007637	Tic20-like protein; Region: Tic20; pfam09685
653938007638	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
653938007639	Cna protein B-type domain; Region: Cna_B; pfam05738
653938007640	Collagen binding domain; Region: Collagen_bind; pfam05737
653938007641	Cna protein B-type domain; Region: Cna_B; pfam05738
653938007642	Cna protein B-type domain; Region: Cna_B; pfam05738
653938007643	Cna protein B-type domain; Region: Cna_B; pfam05738
653938007644	Cna protein B-type domain; Region: Cna_B; pfam05738
653938007645	Cna protein B-type domain; Region: Cna_B; pfam05738
653938007646	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938007647	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938007648	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938007649	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
653938007650	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
653938007651	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
653938007652	active site
653938007653	catalytic site [active]
653938007654	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
653938007655	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
653938007656	Walker A/P-loop; other site
653938007657	ATP binding site [chemical binding]; other site
653938007658	Q-loop/lid; other site
653938007659	ABC transporter signature motif; other site
653938007660	Walker B; other site
653938007661	D-loop; other site
653938007662	H-loop/switch region; other site
653938007663	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
653938007664	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
653938007665	ABC-ATPase subunit  interface; other site
653938007666	dimer interface [polypeptide binding]; other site
653938007667	putative PBP binding regions; other site
653938007668	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
653938007669	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
653938007670	putative ligand binding residues [chemical binding]; other site
653938007671	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
653938007672	heme-binding site [chemical binding]; other site
653938007673	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
653938007674	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
653938007675	heme-binding site [chemical binding]; other site
653938007676	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
653938007677	heme-binding site [chemical binding]; other site
653938007678	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
653938007679	heme uptake protein IsdC; Region: IsdC; TIGR03656
653938007680	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
653938007681	heme-binding site [chemical binding]; other site
653938007682	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
653938007683	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
653938007684	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
653938007685	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
653938007686	active site
653938007687	Zn binding site [ion binding]; other site
653938007688	Competence protein CoiA-like family; Region: CoiA; cl11541
653938007689	Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862
653938007690	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
653938007691	ArsC family; Region: ArsC; pfam03960
653938007692	putative catalytic residues [active]
653938007693	thiol/disulfide switch; other site
653938007694	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
653938007695	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
653938007696	Walker A/P-loop; other site
653938007697	ATP binding site [chemical binding]; other site
653938007698	Q-loop/lid; other site
653938007699	ABC transporter signature motif; other site
653938007700	Walker B; other site
653938007701	D-loop; other site
653938007702	H-loop/switch region; other site
653938007703	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
653938007704	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
653938007705	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
653938007706	Walker A/P-loop; other site
653938007707	ATP binding site [chemical binding]; other site
653938007708	Q-loop/lid; other site
653938007709	ABC transporter signature motif; other site
653938007710	Walker B; other site
653938007711	D-loop; other site
653938007712	H-loop/switch region; other site
653938007713	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
653938007714	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
653938007715	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938007716	dimer interface [polypeptide binding]; other site
653938007717	conserved gate region; other site
653938007718	putative PBP binding loops; other site
653938007719	ABC-ATPase subunit interface; other site
653938007720	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
653938007721	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938007722	dimer interface [polypeptide binding]; other site
653938007723	conserved gate region; other site
653938007724	putative PBP binding loops; other site
653938007725	ABC-ATPase subunit interface; other site
653938007726	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
653938007727	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
653938007728	peptide binding site [polypeptide binding]; other site
653938007729	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
653938007730	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
653938007731	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
653938007732	active site
653938007733	HIGH motif; other site
653938007734	dimer interface [polypeptide binding]; other site
653938007735	KMSKS motif; other site
653938007736	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
653938007737	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
653938007738	MarR family; Region: MarR; pfam01047
653938007739	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
653938007740	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
653938007741	dimer interface [polypeptide binding]; other site
653938007742	active site
653938007743	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
653938007744	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
653938007745	dimer interface [polypeptide binding]; other site
653938007746	active site
653938007747	CoA binding pocket [chemical binding]; other site
653938007748	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
653938007749	SH3-like domain; Region: SH3_8; pfam13457
653938007750	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
653938007751	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
653938007752	catalytic core [active]
653938007753	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
653938007754	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
653938007755	Clp amino terminal domain; Region: Clp_N; pfam02861
653938007756	Clp amino terminal domain; Region: Clp_N; pfam02861
653938007757	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938007758	Walker A motif; other site
653938007759	ATP binding site [chemical binding]; other site
653938007760	Walker B motif; other site
653938007761	arginine finger; other site
653938007762	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938007763	Walker A motif; other site
653938007764	ATP binding site [chemical binding]; other site
653938007765	Walker B motif; other site
653938007766	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
653938007767	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
653938007768	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
653938007769	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
653938007770	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938007771	active site
653938007772	motif I; other site
653938007773	motif II; other site
653938007774	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
653938007775	Predicted acetyltransferase [General function prediction only]; Region: COG3393
653938007776	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
653938007777	ferrochelatase; Provisional; Region: PRK12435
653938007778	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
653938007779	C-terminal domain interface [polypeptide binding]; other site
653938007780	active site
653938007781	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
653938007782	active site
653938007783	N-terminal domain interface [polypeptide binding]; other site
653938007784	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
653938007785	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
653938007786	substrate binding site [chemical binding]; other site
653938007787	active site
653938007788	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
653938007789	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
653938007790	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
653938007791	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
653938007792	Walker A/P-loop; other site
653938007793	ATP binding site [chemical binding]; other site
653938007794	Q-loop/lid; other site
653938007795	ABC transporter signature motif; other site
653938007796	Walker B; other site
653938007797	D-loop; other site
653938007798	H-loop/switch region; other site
653938007799	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
653938007800	HIT family signature motif; other site
653938007801	catalytic residue [active]
653938007802	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
653938007803	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
653938007804	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
653938007805	SurA N-terminal domain; Region: SurA_N_3; cl07813
653938007806	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
653938007807	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
653938007808	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
653938007809	generic binding surface II; other site
653938007810	generic binding surface I; other site
653938007811	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653938007812	Zn2+ binding site [ion binding]; other site
653938007813	Mg2+ binding site [ion binding]; other site
653938007814	Uncharacterized conserved protein [Function unknown]; Region: COG4717
653938007815	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
653938007816	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
653938007817	active site
653938007818	metal binding site [ion binding]; metal-binding site
653938007819	DNA binding site [nucleotide binding]
653938007820	hypothetical protein; Provisional; Region: PRK13676
653938007821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
653938007822	fumarate hydratase; Reviewed; Region: fumC; PRK00485
653938007823	Class II fumarases; Region: Fumarase_classII; cd01362
653938007824	active site
653938007825	tetramer interface [polypeptide binding]; other site
653938007826	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
653938007827	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
653938007828	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
653938007829	Walker A/P-loop; other site
653938007830	ATP binding site [chemical binding]; other site
653938007831	Q-loop/lid; other site
653938007832	ABC transporter signature motif; other site
653938007833	Walker B; other site
653938007834	D-loop; other site
653938007835	H-loop/switch region; other site
653938007836	Transglycosylase; Region: Transgly; pfam00912
653938007837	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
653938007838	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
653938007839	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
653938007840	Low molecular weight phosphatase family; Region: LMWPc; cl00105
653938007841	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
653938007842	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
653938007843	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
653938007844	Domain of unknown function DUF21; Region: DUF21; pfam01595
653938007845	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
653938007846	Transporter associated domain; Region: CorC_HlyC; smart01091
653938007847	Transcriptional regulator [Transcription]; Region: LysR; COG0583
653938007848	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
653938007849	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
653938007850	putative dimerization interface [polypeptide binding]; other site
653938007851	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
653938007852	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
653938007853	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
653938007854	active site
653938007855	FMN binding site [chemical binding]; other site
653938007856	substrate binding site [chemical binding]; other site
653938007857	putative catalytic residue [active]
653938007858	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
653938007859	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653938007860	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
653938007861	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
653938007862	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
653938007863	shikimate binding site; other site
653938007864	NAD(P) binding site [chemical binding]; other site
653938007865	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938007866	putative substrate translocation pore; other site
653938007867	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653938007868	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938007869	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653938007870	putative substrate translocation pore; other site
653938007871	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
653938007872	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938007873	Walker A/P-loop; other site
653938007874	ATP binding site [chemical binding]; other site
653938007875	Q-loop/lid; other site
653938007876	ABC transporter signature motif; other site
653938007877	Walker B; other site
653938007878	D-loop; other site
653938007879	H-loop/switch region; other site
653938007880	Predicted transcriptional regulators [Transcription]; Region: COG1725
653938007881	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938007882	DNA-binding site [nucleotide binding]; DNA binding site
653938007883	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
653938007884	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
653938007885	DNA binding site [nucleotide binding]
653938007886	active site
653938007887	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
653938007888	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
653938007889	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
653938007890	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
653938007891	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
653938007892	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
653938007893	active site
653938007894	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
653938007895	putative dimer interface [polypeptide binding]; other site
653938007896	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
653938007897	ligand binding site [chemical binding]; other site
653938007898	Zn binding site [ion binding]; other site
653938007899	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
653938007900	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
653938007901	active site
653938007902	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
653938007903	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
653938007904	active site
653938007905	catalytic tetrad [active]
653938007906	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
653938007907	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
653938007908	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
653938007909	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
653938007910	substrate binding pocket [chemical binding]; other site
653938007911	membrane-bound complex binding site; other site
653938007912	hinge residues; other site
653938007913	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
653938007914	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938007915	dimer interface [polypeptide binding]; other site
653938007916	conserved gate region; other site
653938007917	putative PBP binding loops; other site
653938007918	ABC-ATPase subunit interface; other site
653938007919	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
653938007920	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
653938007921	Walker A/P-loop; other site
653938007922	ATP binding site [chemical binding]; other site
653938007923	Q-loop/lid; other site
653938007924	ABC transporter signature motif; other site
653938007925	Walker B; other site
653938007926	D-loop; other site
653938007927	H-loop/switch region; other site
653938007928	aspartate aminotransferase; Provisional; Region: PRK06348
653938007929	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
653938007930	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938007931	homodimer interface [polypeptide binding]; other site
653938007932	catalytic residue [active]
653938007933	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
653938007934	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
653938007935	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938007936	motif II; other site
653938007937	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
653938007938	intracellular protease, PfpI family; Region: PfpI; TIGR01382
653938007939	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
653938007940	proposed catalytic triad [active]
653938007941	conserved cys residue [active]
653938007942	basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576
653938007943	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
653938007944	methionine cluster; other site
653938007945	active site
653938007946	phosphorylation site [posttranslational modification]
653938007947	metal binding site [ion binding]; metal-binding site
653938007948	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
653938007949	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938007950	Coenzyme A binding pocket [chemical binding]; other site
653938007951	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
653938007952	esterase; Provisional; Region: PRK10566
653938007953	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
653938007954	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
653938007955	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
653938007956	motif II; other site
653938007957	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938007958	Uncharacterized conserved protein [Function unknown]; Region: COG1284
653938007959	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
653938007960	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
653938007961	hypothetical protein; Provisional; Region: PRK13673
653938007962	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
653938007963	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
653938007964	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
653938007965	Part of AAA domain; Region: AAA_19; pfam13245
653938007966	Family description; Region: UvrD_C_2; pfam13538
653938007967	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
653938007968	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
653938007969	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
653938007970	IDEAL domain; Region: IDEAL; pfam08858
653938007971	ComK protein; Region: ComK; cl11560
653938007972	AP2 domain; Region: AP2; pfam00847
653938007973	Domain of unknown function (DUF3825); Region: DUF3825; pfam12873
653938007974	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
653938007975	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
653938007976	Phage holin; Region: Phage_holin_5; pfam06946
653938007977	Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669
653938007978	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
653938007979	Phage tail protein; Region: Sipho_tail; cl17486
653938007980	Phage-related tail protein [Function unknown]; Region: COG5283
653938007981	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
653938007982	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
653938007983	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
653938007984	phage terminase, large subunit, PBSX family; Region: phage_term_2; TIGR01547
653938007985	Terminase-like family; Region: Terminase_6; pfam03237
653938007986	Uncharacterized conserved protein [Function unknown]; Region: COG5484
653938007987	Phage terminase small subunit; Region: Phage_terminase; pfam10668
653938007988	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
653938007989	Protein of unknown function (DUF2481); Region: DUF2481; pfam10654
653938007990	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
653938007991	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
653938007992	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
653938007993	dimer interface [polypeptide binding]; other site
653938007994	ssDNA binding site [nucleotide binding]; other site
653938007995	tetramer (dimer of dimers) interface [polypeptide binding]; other site
653938007996	Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961
653938007997	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
653938007998	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
653938007999	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
653938008000	ERF superfamily; Region: ERF; pfam04404
653938008001	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
653938008002	Protein gp45 of Bacteriophage A118; Region: Phage-A118_gp45; pfam10653
653938008003	AntA/AntB antirepressor; Region: AntA; pfam08346
653938008004	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
653938008005	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
653938008006	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938008007	non-specific DNA binding site [nucleotide binding]; other site
653938008008	salt bridge; other site
653938008009	sequence-specific DNA binding site [nucleotide binding]; other site
653938008010	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
653938008011	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938008012	non-specific DNA binding site [nucleotide binding]; other site
653938008013	salt bridge; other site
653938008014	sequence-specific DNA binding site [nucleotide binding]; other site
653938008015	Domain of unknown function (DUF955); Region: DUF955; pfam06114
653938008016	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
653938008017	Divergent AAA domain; Region: AAA_4; pfam04326
653938008018	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
653938008019	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
653938008020	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
653938008021	catalytic residues [active]
653938008022	catalytic nucleophile [active]
653938008023	Presynaptic Site I dimer interface [polypeptide binding]; other site
653938008024	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
653938008025	Synaptic Flat tetramer interface [polypeptide binding]; other site
653938008026	Synaptic Site I dimer interface [polypeptide binding]; other site
653938008027	DNA binding site [nucleotide binding]
653938008028	Recombinase; Region: Recombinase; pfam07508
653938008029	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
653938008030	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
653938008031	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938008032	non-specific DNA binding site [nucleotide binding]; other site
653938008033	salt bridge; other site
653938008034	sequence-specific DNA binding site [nucleotide binding]; other site
653938008035	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
653938008036	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653938008037	active site
653938008038	phosphorylation site [posttranslational modification]
653938008039	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
653938008040	active site
653938008041	P-loop; other site
653938008042	phosphorylation site [posttranslational modification]
653938008043	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
653938008044	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
653938008045	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
653938008046	putative substrate binding site [chemical binding]; other site
653938008047	putative ATP binding site [chemical binding]; other site
653938008048	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
653938008049	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
653938008050	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
653938008051	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
653938008052	trimer interface [polypeptide binding]; other site
653938008053	active site
653938008054	G bulge; other site
653938008055	Uncharacterized conserved protein [Function unknown]; Region: COG1683
653938008056	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
653938008057	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
653938008058	non-specific DNA interactions [nucleotide binding]; other site
653938008059	DNA binding site [nucleotide binding]
653938008060	sequence specific DNA binding site [nucleotide binding]; other site
653938008061	putative cAMP binding site [chemical binding]; other site
653938008062	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
653938008063	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
653938008064	substrate binding site [chemical binding]; other site
653938008065	ATP binding site [chemical binding]; other site
653938008066	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
653938008067	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
653938008068	RNA binding surface [nucleotide binding]; other site
653938008069	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
653938008070	active site
653938008071	uracil binding [chemical binding]; other site
653938008072	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
653938008073	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
653938008074	active site
653938008075	non-prolyl cis peptide bond; other site
653938008076	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
653938008077	catalytic residues [active]
653938008078	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
653938008079	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
653938008080	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
653938008081	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
653938008082	Walker A/P-loop; other site
653938008083	ATP binding site [chemical binding]; other site
653938008084	Q-loop/lid; other site
653938008085	ABC transporter signature motif; other site
653938008086	Walker B; other site
653938008087	D-loop; other site
653938008088	H-loop/switch region; other site
653938008089	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
653938008090	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938008091	dimer interface [polypeptide binding]; other site
653938008092	conserved gate region; other site
653938008093	putative PBP binding loops; other site
653938008094	ABC-ATPase subunit interface; other site
653938008095	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
653938008096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938008097	dimer interface [polypeptide binding]; other site
653938008098	conserved gate region; other site
653938008099	putative PBP binding loops; other site
653938008100	ABC-ATPase subunit interface; other site
653938008101	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
653938008102	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
653938008103	substrate binding pocket [chemical binding]; other site
653938008104	membrane-bound complex binding site; other site
653938008105	hinge residues; other site
653938008106	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938008107	Coenzyme A binding pocket [chemical binding]; other site
653938008108	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
653938008109	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
653938008110	Transcriptional regulator [Transcription]; Region: LysR; COG0583
653938008111	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
653938008112	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
653938008113	dimerization interface [polypeptide binding]; other site
653938008114	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
653938008115	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
653938008116	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
653938008117	active site
653938008118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938008119	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653938008120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938008121	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653938008122	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
653938008123	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
653938008124	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
653938008125	active site
653938008126	trimer interface [polypeptide binding]; other site
653938008127	allosteric site; other site
653938008128	active site lid [active]
653938008129	hexamer (dimer of trimers) interface [polypeptide binding]; other site
653938008130	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
653938008131	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938008132	active site
653938008133	motif I; other site
653938008134	motif II; other site
653938008135	Predicted membrane protein [Function unknown]; Region: COG1511
653938008136	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
653938008137	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
653938008138	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
653938008139	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
653938008140	Predicted transcriptional regulator [Transcription]; Region: COG1959
653938008141	Transcriptional regulator; Region: Rrf2; pfam02082
653938008142	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
653938008143	L-tyrosine decarboxylase; Provisional; Region: PRK13520
653938008144	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
653938008145	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938008146	catalytic residue [active]
653938008147	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
653938008148	Mga helix-turn-helix domain; Region: Mga; pfam05043
653938008149	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
653938008150	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
653938008151	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
653938008152	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
653938008153	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
653938008154	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
653938008155	active site
653938008156	dimer interface [polypeptide binding]; other site
653938008157	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
653938008158	dimer interface [polypeptide binding]; other site
653938008159	active site
653938008160	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
653938008161	nudix motif; other site
653938008162	general stress protein 13; Validated; Region: PRK08059
653938008163	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
653938008164	RNA binding site [nucleotide binding]; other site
653938008165	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
653938008166	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
653938008167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938008168	homodimer interface [polypeptide binding]; other site
653938008169	catalytic residue [active]
653938008170	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
653938008171	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
653938008172	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653938008173	Walker A/P-loop; other site
653938008174	ATP binding site [chemical binding]; other site
653938008175	Q-loop/lid; other site
653938008176	ABC transporter signature motif; other site
653938008177	Walker B; other site
653938008178	D-loop; other site
653938008179	H-loop/switch region; other site
653938008180	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
653938008181	active site
653938008182	P-loop; other site
653938008183	phosphorylation site [posttranslational modification]
653938008184	aspartate kinase; Reviewed; Region: PRK09034
653938008185	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
653938008186	putative catalytic residues [active]
653938008187	putative nucleotide binding site [chemical binding]; other site
653938008188	putative aspartate binding site [chemical binding]; other site
653938008189	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
653938008190	allosteric regulatory residue; other site
653938008191	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
653938008192	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
653938008193	active site
653938008194	drug efflux system protein MdtG; Provisional; Region: PRK09874
653938008195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938008196	putative substrate translocation pore; other site
653938008197	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
653938008198	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
653938008199	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
653938008200	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
653938008201	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
653938008202	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
653938008203	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
653938008204	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
653938008205	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
653938008206	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585
653938008207	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
653938008208	CoenzymeA binding site [chemical binding]; other site
653938008209	subunit interaction site [polypeptide binding]; other site
653938008210	PHB binding site; other site
653938008211	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963
653938008212	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
653938008213	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
653938008214	Cl- selectivity filter; other site
653938008215	Cl- binding residues [ion binding]; other site
653938008216	pore gating glutamate residue; other site
653938008217	dimer interface [polypeptide binding]; other site
653938008218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
653938008219	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
653938008220	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653938008221	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
653938008222	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
653938008223	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653938008224	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
653938008225	NADH(P)-binding; Region: NAD_binding_10; pfam13460
653938008226	NAD(P) binding site [chemical binding]; other site
653938008227	putative active site [active]
653938008228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844
653938008229	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
653938008230	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938008231	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938008232	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938008233	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938008234	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
653938008235	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
653938008236	tetramer interfaces [polypeptide binding]; other site
653938008237	binuclear metal-binding site [ion binding]; other site
653938008238	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
653938008239	Domain of unknown function DUF21; Region: DUF21; pfam01595
653938008240	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
653938008241	Transporter associated domain; Region: CorC_HlyC; smart01091
653938008242	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
653938008243	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938008244	Coenzyme A binding pocket [chemical binding]; other site
653938008245	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
653938008246	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938008247	active site
653938008248	motif I; other site
653938008249	motif II; other site
653938008250	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938008251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
653938008252	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
653938008253	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
653938008254	active site
653938008255	metal binding site [ion binding]; metal-binding site
653938008256	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
653938008257	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
653938008258	Predicted membrane protein [Function unknown]; Region: COG4272
653938008259	Uncharacterized conserved protein [Function unknown]; Region: COG1801
653938008260	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
653938008261	FeS assembly protein SufB; Region: sufB; TIGR01980
653938008262	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
653938008263	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
653938008264	trimerization site [polypeptide binding]; other site
653938008265	active site
653938008266	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
653938008267	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
653938008268	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
653938008269	catalytic residue [active]
653938008270	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
653938008271	FeS assembly protein SufD; Region: sufD; TIGR01981
653938008272	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
653938008273	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
653938008274	Walker A/P-loop; other site
653938008275	ATP binding site [chemical binding]; other site
653938008276	Q-loop/lid; other site
653938008277	ABC transporter signature motif; other site
653938008278	Walker B; other site
653938008279	D-loop; other site
653938008280	H-loop/switch region; other site
653938008281	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
653938008282	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
653938008283	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938008284	ABC-ATPase subunit interface; other site
653938008285	putative PBP binding loops; other site
653938008286	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
653938008287	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
653938008288	Walker A/P-loop; other site
653938008289	ATP binding site [chemical binding]; other site
653938008290	Q-loop/lid; other site
653938008291	ABC transporter signature motif; other site
653938008292	Walker B; other site
653938008293	D-loop; other site
653938008294	H-loop/switch region; other site
653938008295	NIL domain; Region: NIL; pfam09383
653938008296	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653938008297	dimer interface [polypeptide binding]; other site
653938008298	phosphorylation site [posttranslational modification]
653938008299	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938008300	ATP binding site [chemical binding]; other site
653938008301	Mg2+ binding site [ion binding]; other site
653938008302	G-X-G motif; other site
653938008303	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
653938008304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938008305	active site
653938008306	phosphorylation site [posttranslational modification]
653938008307	intermolecular recognition site; other site
653938008308	dimerization interface [polypeptide binding]; other site
653938008309	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
653938008310	DNA binding site [nucleotide binding]
653938008311	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
653938008312	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
653938008313	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
653938008314	catalytic residues [active]
653938008315	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
653938008316	lipoyl attachment site [posttranslational modification]; other site
653938008317	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
653938008318	ArsC family; Region: ArsC; pfam03960
653938008319	putative ArsC-like catalytic residues; other site
653938008320	putative TRX-like catalytic residues [active]
653938008321	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
653938008322	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
653938008323	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
653938008324	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
653938008325	Walker A/P-loop; other site
653938008326	ATP binding site [chemical binding]; other site
653938008327	Q-loop/lid; other site
653938008328	ABC transporter signature motif; other site
653938008329	Walker B; other site
653938008330	D-loop; other site
653938008331	H-loop/switch region; other site
653938008332	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
653938008333	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
653938008334	ABC-ATPase subunit  interface; other site
653938008335	dimer interface [polypeptide binding]; other site
653938008336	putative PBP binding regions; other site
653938008337	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
653938008338	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
653938008339	intersubunit interface [polypeptide binding]; other site
653938008340	Predicted esterase [General function prediction only]; Region: COG0627
653938008341	S-formylglutathione hydrolase; Region: PLN02442
653938008342	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
653938008343	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938008344	catalytic residue [active]
653938008345	SdpI/YhfL protein family; Region: SdpI; pfam13630
653938008346	CAT RNA binding domain; Region: CAT_RBD; smart01061
653938008347	transcriptional antiterminator BglG; Provisional; Region: PRK09772
653938008348	PRD domain; Region: PRD; pfam00874
653938008349	PRD domain; Region: PRD; pfam00874
653938008350	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
653938008351	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
653938008352	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
653938008353	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
653938008354	Predicted transcriptional regulator [Transcription]; Region: COG2378
653938008355	HTH domain; Region: HTH_11; pfam08279
653938008356	WYL domain; Region: WYL; pfam13280
653938008357	Uncharacterized conserved protein [Function unknown]; Region: COG1434
653938008358	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
653938008359	putative active site [active]
653938008360	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
653938008361	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
653938008362	active site
653938008363	catalytic site [active]
653938008364	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
653938008365	putative metal binding site [ion binding]; other site
653938008366	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
653938008367	putative metal binding site [ion binding]; other site
653938008368	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
653938008369	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
653938008370	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
653938008371	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
653938008372	active site
653938008373	catalytic site [active]
653938008374	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
653938008375	putative metal binding site [ion binding]; other site
653938008376	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938008377	non-specific DNA binding site [nucleotide binding]; other site
653938008378	salt bridge; other site
653938008379	sequence-specific DNA binding site [nucleotide binding]; other site
653938008380	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
653938008381	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
653938008382	SmpB-tmRNA interface; other site
653938008383	ribonuclease R; Region: RNase_R; TIGR02063
653938008384	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
653938008385	RNB domain; Region: RNB; pfam00773
653938008386	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
653938008387	RNA binding site [nucleotide binding]; other site
653938008388	Esterase/lipase [General function prediction only]; Region: COG1647
653938008389	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
653938008390	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
653938008391	Preprotein translocase SecG subunit; Region: SecG; cl09123
653938008392	Esterase/lipase [General function prediction only]; Region: COG1647
653938008393	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
653938008394	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
653938008395	PGAP1-like protein; Region: PGAP1; pfam07819
653938008396	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
653938008397	enolase; Provisional; Region: eno; PRK00077
653938008398	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
653938008399	dimer interface [polypeptide binding]; other site
653938008400	metal binding site [ion binding]; metal-binding site
653938008401	substrate binding pocket [chemical binding]; other site
653938008402	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
653938008403	phosphoglyceromutase; Provisional; Region: PRK05434
653938008404	triosephosphate isomerase; Provisional; Region: PRK14567
653938008405	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
653938008406	substrate binding site [chemical binding]; other site
653938008407	dimer interface [polypeptide binding]; other site
653938008408	catalytic triad [active]
653938008409	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
653938008410	Phosphoglycerate kinase; Region: PGK; pfam00162
653938008411	substrate binding site [chemical binding]; other site
653938008412	hinge regions; other site
653938008413	ADP binding site [chemical binding]; other site
653938008414	catalytic site [active]
653938008415	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
653938008416	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
653938008417	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
653938008418	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
653938008419	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
653938008420	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
653938008421	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
653938008422	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
653938008423	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
653938008424	DNA binding site [nucleotide binding]
653938008425	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
653938008426	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
653938008427	active site
653938008428	dimer interface [polypeptide binding]; other site
653938008429	MMPL family; Region: MMPL; pfam03176
653938008430	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
653938008431	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
653938008432	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
653938008433	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
653938008434	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
653938008435	Chitin binding domain; Region: Chitin_bind_3; pfam03067
653938008436	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
653938008437	Interdomain contacts; other site
653938008438	Cytokine receptor motif; other site
653938008439	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
653938008440	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
653938008441	Interdomain contacts; other site
653938008442	Cytokine receptor motif; other site
653938008443	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
653938008444	aromatic chitin/cellulose binding site residues [chemical binding]; other site
653938008445	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
653938008446	aromatic chitin/cellulose binding site residues [chemical binding]; other site
653938008447	Clp protease; Region: CLP_protease; pfam00574
653938008448	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
653938008449	oligomer interface [polypeptide binding]; other site
653938008450	active site residues [active]
653938008451	amino acid transporter; Region: 2A0306; TIGR00909
653938008452	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
653938008453	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
653938008454	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
653938008455	Substrate binding site [chemical binding]; other site
653938008456	Leucine rich repeat; Region: LRR_8; pfam13855
653938008457	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653938008458	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
653938008459	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
653938008460	active site
653938008461	FMN binding site [chemical binding]; other site
653938008462	substrate binding site [chemical binding]; other site
653938008463	homotetramer interface [polypeptide binding]; other site
653938008464	catalytic residue [active]
653938008465	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
653938008466	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
653938008467	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
653938008468	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
653938008469	phosphate binding site [ion binding]; other site
653938008470	putative substrate binding pocket [chemical binding]; other site
653938008471	dimer interface [polypeptide binding]; other site
653938008472	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
653938008473	AAA domain; Region: AAA_18; pfam13238
653938008474	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
653938008475	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
653938008476	active site
653938008477	substrate binding site [chemical binding]; other site
653938008478	metal binding site [ion binding]; metal-binding site
653938008479	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
653938008480	active site
653938008481	catalytic residues [active]
653938008482	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
653938008483	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
653938008484	NAD binding site [chemical binding]; other site
653938008485	homodimer interface [polypeptide binding]; other site
653938008486	active site
653938008487	substrate binding site [chemical binding]; other site
653938008488	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
653938008489	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
653938008490	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653938008491	TPR repeat; Region: TPR_11; pfam13414
653938008492	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653938008493	binding surface
653938008494	TPR motif; other site
653938008495	Tetratricopeptide repeat; Region: TPR_12; pfam13424
653938008496	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653938008497	binding surface
653938008498	TPR motif; other site
653938008499	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
653938008500	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
653938008501	putative trimer interface [polypeptide binding]; other site
653938008502	putative CoA binding site [chemical binding]; other site
653938008503	pyrophosphatase PpaX; Provisional; Region: PRK13288
653938008504	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
653938008505	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938008506	motif II; other site
653938008507	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
653938008508	HPr kinase/phosphorylase; Provisional; Region: PRK05428
653938008509	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
653938008510	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
653938008511	Hpr binding site; other site
653938008512	active site
653938008513	homohexamer subunit interaction site [polypeptide binding]; other site
653938008514	Predicted membrane protein [Function unknown]; Region: COG1950
653938008515	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
653938008516	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
653938008517	Uncharacterized conserved protein [Function unknown]; Region: COG3595
653938008518	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
653938008519	Uncharacterized conserved protein [Function unknown]; Region: COG3595
653938008520	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
653938008521	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
653938008522	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
653938008523	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
653938008524	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
653938008525	excinuclease ABC subunit B; Provisional; Region: PRK05298
653938008526	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653938008527	ATP binding site [chemical binding]; other site
653938008528	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653938008529	nucleotide binding region [chemical binding]; other site
653938008530	ATP-binding site [chemical binding]; other site
653938008531	Ultra-violet resistance protein B; Region: UvrB; pfam12344
653938008532	UvrB/uvrC motif; Region: UVR; pfam02151
653938008533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897
653938008534	HD containing hydrolase-like enzyme; Region: HD_2; pfam12917
653938008535	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
653938008536	dimerization interface [polypeptide binding]; other site
653938008537	putative DNA binding site [nucleotide binding]; other site
653938008538	putative Zn2+ binding site [ion binding]; other site
653938008539	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
653938008540	PhoU domain; Region: PhoU; pfam01895
653938008541	PhoU domain; Region: PhoU; pfam01895
653938008542	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
653938008543	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
653938008544	Walker A/P-loop; other site
653938008545	ATP binding site [chemical binding]; other site
653938008546	Q-loop/lid; other site
653938008547	ABC transporter signature motif; other site
653938008548	Walker B; other site
653938008549	D-loop; other site
653938008550	H-loop/switch region; other site
653938008551	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
653938008552	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
653938008553	Walker A/P-loop; other site
653938008554	ATP binding site [chemical binding]; other site
653938008555	Q-loop/lid; other site
653938008556	ABC transporter signature motif; other site
653938008557	Walker B; other site
653938008558	D-loop; other site
653938008559	H-loop/switch region; other site
653938008560	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
653938008561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938008562	dimer interface [polypeptide binding]; other site
653938008563	conserved gate region; other site
653938008564	putative PBP binding loops; other site
653938008565	ABC-ATPase subunit interface; other site
653938008566	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
653938008567	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938008568	dimer interface [polypeptide binding]; other site
653938008569	conserved gate region; other site
653938008570	putative PBP binding loops; other site
653938008571	ABC-ATPase subunit interface; other site
653938008572	PBP superfamily domain; Region: PBP_like_2; cl17296
653938008573	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
653938008574	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
653938008575	HAMP domain; Region: HAMP; pfam00672
653938008576	dimerization interface [polypeptide binding]; other site
653938008577	PAS domain; Region: PAS; smart00091
653938008578	putative active site [active]
653938008579	heme pocket [chemical binding]; other site
653938008580	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653938008581	dimer interface [polypeptide binding]; other site
653938008582	phosphorylation site [posttranslational modification]
653938008583	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938008584	ATP binding site [chemical binding]; other site
653938008585	Mg2+ binding site [ion binding]; other site
653938008586	G-X-G motif; other site
653938008587	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
653938008588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938008589	active site
653938008590	phosphorylation site [posttranslational modification]
653938008591	intermolecular recognition site; other site
653938008592	dimerization interface [polypeptide binding]; other site
653938008593	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
653938008594	DNA binding site [nucleotide binding]
653938008595	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
653938008596	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
653938008597	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
653938008598	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
653938008599	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
653938008600	putative active site [active]
653938008601	catalytic site [active]
653938008602	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
653938008603	putative active site [active]
653938008604	catalytic site [active]
653938008605	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
653938008606	Peptidase family M23; Region: Peptidase_M23; pfam01551
653938008607	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
653938008608	NlpC/P60 family; Region: NLPC_P60; pfam00877
653938008609	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
653938008610	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
653938008611	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
653938008612	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938008613	Walker A/P-loop; other site
653938008614	ATP binding site [chemical binding]; other site
653938008615	Q-loop/lid; other site
653938008616	ABC transporter signature motif; other site
653938008617	Walker B; other site
653938008618	D-loop; other site
653938008619	H-loop/switch region; other site
653938008620	Uncharacterized conserved protein [Function unknown]; Region: COG1284
653938008621	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
653938008622	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
653938008623	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
653938008624	peptide chain release factor 2; Validated; Region: prfB; PRK00578
653938008625	This domain is found in peptide chain release factors; Region: PCRF; smart00937
653938008626	RF-1 domain; Region: RF-1; pfam00472
653938008627	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
653938008628	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
653938008629	nucleotide binding region [chemical binding]; other site
653938008630	helicase superfamily c-terminal domain; Region: HELICc; smart00490
653938008631	ATP-binding site [chemical binding]; other site
653938008632	SEC-C motif; Region: SEC-C; pfam02810
653938008633	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
653938008634	30S subunit binding site; other site
653938008635	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
653938008636	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653938008637	active site
653938008638	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
653938008639	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653938008640	ATP binding site [chemical binding]; other site
653938008641	putative Mg++ binding site [ion binding]; other site
653938008642	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653938008643	nucleotide binding region [chemical binding]; other site
653938008644	ATP-binding site [chemical binding]; other site
653938008645	EDD domain protein, DegV family; Region: DegV; TIGR00762
653938008646	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
653938008647	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
653938008648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938008649	active site
653938008650	phosphorylation site [posttranslational modification]
653938008651	intermolecular recognition site; other site
653938008652	dimerization interface [polypeptide binding]; other site
653938008653	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
653938008654	DNA binding residues [nucleotide binding]
653938008655	dimerization interface [polypeptide binding]; other site
653938008656	Uncharacterized conserved protein [Function unknown]; Region: COG1739
653938008657	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
653938008658	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
653938008659	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
653938008660	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
653938008661	Transcriptional regulator [Transcription]; Region: LytR; COG1316
653938008662	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
653938008663	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
653938008664	Mg++ binding site [ion binding]; other site
653938008665	putative catalytic motif [active]
653938008666	substrate binding site [chemical binding]; other site
653938008667	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
653938008668	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
653938008669	active site
653938008670	octamer interface [polypeptide binding]; other site
653938008671	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
653938008672	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
653938008673	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653938008674	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653938008675	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
653938008676	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
653938008677	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
653938008678	dimer interface [polypeptide binding]; other site
653938008679	ssDNA binding site [nucleotide binding]; other site
653938008680	tetramer (dimer of dimers) interface [polypeptide binding]; other site
653938008681	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
653938008682	rod shape-determining protein Mbl; Provisional; Region: PRK13928
653938008683	MreB and similar proteins; Region: MreB_like; cd10225
653938008684	nucleotide binding site [chemical binding]; other site
653938008685	Mg binding site [ion binding]; other site
653938008686	putative protofilament interaction site [polypeptide binding]; other site
653938008687	RodZ interaction site [polypeptide binding]; other site
653938008688	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
653938008689	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
653938008690	hinge; other site
653938008691	active site
653938008692	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
653938008693	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
653938008694	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
653938008695	gamma subunit interface [polypeptide binding]; other site
653938008696	epsilon subunit interface [polypeptide binding]; other site
653938008697	LBP interface [polypeptide binding]; other site
653938008698	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
653938008699	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
653938008700	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
653938008701	alpha subunit interaction interface [polypeptide binding]; other site
653938008702	Walker A motif; other site
653938008703	ATP binding site [chemical binding]; other site
653938008704	Walker B motif; other site
653938008705	inhibitor binding site; inhibition site
653938008706	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
653938008707	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
653938008708	core domain interface [polypeptide binding]; other site
653938008709	delta subunit interface [polypeptide binding]; other site
653938008710	epsilon subunit interface [polypeptide binding]; other site
653938008711	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
653938008712	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
653938008713	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
653938008714	beta subunit interaction interface [polypeptide binding]; other site
653938008715	Walker A motif; other site
653938008716	ATP binding site [chemical binding]; other site
653938008717	Walker B motif; other site
653938008718	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
653938008719	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
653938008720	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
653938008721	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
653938008722	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
653938008723	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
653938008724	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
653938008725	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
653938008726	ATP synthase I chain; Region: ATP_synt_I; pfam03899
653938008727	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
653938008728	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
653938008729	active site
653938008730	homodimer interface [polypeptide binding]; other site
653938008731	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653938008732	active site
653938008733	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
653938008734	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
653938008735	dimer interface [polypeptide binding]; other site
653938008736	active site
653938008737	glycine-pyridoxal phosphate binding site [chemical binding]; other site
653938008738	folate binding site [chemical binding]; other site
653938008739	Low molecular weight phosphatase family; Region: LMWPc; cd00115
653938008740	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
653938008741	active site
653938008742	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
653938008743	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
653938008744	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
653938008745	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938008746	S-adenosylmethionine binding site [chemical binding]; other site
653938008747	peptide chain release factor 1; Validated; Region: prfA; PRK00591
653938008748	This domain is found in peptide chain release factors; Region: PCRF; smart00937
653938008749	RF-1 domain; Region: RF-1; pfam00472
653938008750	thymidine kinase; Provisional; Region: PRK04296
653938008751	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
653938008752	ATP binding site [chemical binding]; other site
653938008753	Walker A motif; other site
653938008754	Walker B motif; other site
653938008755	homoserine kinase; Provisional; Region: PRK01212
653938008756	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
653938008757	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
653938008758	threonine synthase; Reviewed; Region: PRK06721
653938008759	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
653938008760	homodimer interface [polypeptide binding]; other site
653938008761	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938008762	catalytic residue [active]
653938008763	homoserine dehydrogenase; Provisional; Region: PRK06349
653938008764	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
653938008765	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
653938008766	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
653938008767	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
653938008768	Predicted membrane protein [Function unknown]; Region: COG2246
653938008769	GtrA-like protein; Region: GtrA; pfam04138
653938008770	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
653938008771	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
653938008772	Ligand binding site; other site
653938008773	Putative Catalytic site; other site
653938008774	DXD motif; other site
653938008775	transcription termination factor Rho; Provisional; Region: rho; PRK09376
653938008776	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
653938008777	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
653938008778	RNA binding site [nucleotide binding]; other site
653938008779	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
653938008780	multimer interface [polypeptide binding]; other site
653938008781	Walker A motif; other site
653938008782	ATP binding site [chemical binding]; other site
653938008783	Walker B motif; other site
653938008784	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
653938008785	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
653938008786	hinge; other site
653938008787	active site
653938008788	Predicted integral membrane protein [Function unknown]; Region: COG0392
653938008789	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
653938008790	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
653938008791	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
653938008792	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
653938008793	putative ADP-binding pocket [chemical binding]; other site
653938008794	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
653938008795	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
653938008796	intersubunit interface [polypeptide binding]; other site
653938008797	active site
653938008798	zinc binding site [ion binding]; other site
653938008799	Na+ binding site [ion binding]; other site
653938008800	putative lipid kinase; Reviewed; Region: PRK13055
653938008801	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
653938008802	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
653938008803	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
653938008804	amidase catalytic site [active]
653938008805	Zn binding residues [ion binding]; other site
653938008806	substrate binding site [chemical binding]; other site
653938008807	SH3-like domain; Region: SH3_8; pfam13457
653938008808	SH3-like domain; Region: SH3_8; pfam13457
653938008809	SH3-like domain; Region: SH3_8; pfam13457
653938008810	SH3-like domain; Region: SH3_8; pfam13457
653938008811	CTP synthetase; Validated; Region: pyrG; PRK05380
653938008812	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
653938008813	Catalytic site [active]
653938008814	active site
653938008815	UTP binding site [chemical binding]; other site
653938008816	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
653938008817	active site
653938008818	putative oxyanion hole; other site
653938008819	catalytic triad [active]
653938008820	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
653938008821	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
653938008822	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
653938008823	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
653938008824	active site
653938008825	HIGH motif; other site
653938008826	KMSK motif region; other site
653938008827	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
653938008828	tRNA binding surface [nucleotide binding]; other site
653938008829	anticodon binding site; other site
653938008830	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
653938008831	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
653938008832	Peptidase family M50; Region: Peptidase_M50; pfam02163
653938008833	active site
653938008834	putative substrate binding region [chemical binding]; other site
653938008835	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
653938008836	active site 1 [active]
653938008837	dimer interface [polypeptide binding]; other site
653938008838	hexamer interface [polypeptide binding]; other site
653938008839	active site 2 [active]
653938008840	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
653938008841	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653938008842	Zn2+ binding site [ion binding]; other site
653938008843	Mg2+ binding site [ion binding]; other site
653938008844	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
653938008845	conserved hypothetical protein TIGR01655; Region: yxeA_fam
653938008846	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
653938008847	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
653938008848	peptide binding site [polypeptide binding]; other site
653938008849	Predicted integral membrane protein [Function unknown]; Region: COG5658
653938008850	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
653938008851	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
653938008852	catalytic triad [active]
653938008853	metal binding site [ion binding]; metal-binding site
653938008854	conserved cis-peptide bond; other site
653938008855	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
653938008856	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
653938008857	folate binding site [chemical binding]; other site
653938008858	NADP+ binding site [chemical binding]; other site
653938008859	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
653938008860	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
653938008861	putative NAD(P) binding site [chemical binding]; other site
653938008862	dimer interface [polypeptide binding]; other site
653938008863	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
653938008864	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
653938008865	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
653938008866	Collagen binding domain; Region: Collagen_bind; pfam05737
653938008867	Collagen binding domain; Region: Collagen_bind; pfam05737
653938008868	Collagen binding domain; Region: Collagen_bind; pfam05737
653938008869	Cna protein B-type domain; Region: Cna_B; pfam05738
653938008870	Cna protein B-type domain; Region: Cna_B; pfam05738
653938008871	Cna protein B-type domain; Region: Cna_B; pfam05738
653938008872	Cna protein B-type domain; Region: Cna_B; pfam05738
653938008873	Cna protein B-type domain; Region: Cna_B; pfam05738
653938008874	Cna protein B-type domain; Region: Cna_B; pfam05738
653938008875	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
653938008876	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
653938008877	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938008878	active site
653938008879	motif I; other site
653938008880	motif II; other site
653938008881	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
653938008882	Uncharacterized conserved protein [Function unknown]; Region: COG1359
653938008883	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
653938008884	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653938008885	Walker A/P-loop; other site
653938008886	ATP binding site [chemical binding]; other site
653938008887	Q-loop/lid; other site
653938008888	ABC transporter signature motif; other site
653938008889	Walker B; other site
653938008890	D-loop; other site
653938008891	H-loop/switch region; other site
653938008892	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
653938008893	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
653938008894	FtsX-like permease family; Region: FtsX; pfam02687
653938008895	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653938008896	dimerization interface [polypeptide binding]; other site
653938008897	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653938008898	dimer interface [polypeptide binding]; other site
653938008899	phosphorylation site [posttranslational modification]
653938008900	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938008901	ATP binding site [chemical binding]; other site
653938008902	Mg2+ binding site [ion binding]; other site
653938008903	G-X-G motif; other site
653938008904	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
653938008905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938008906	active site
653938008907	phosphorylation site [posttranslational modification]
653938008908	intermolecular recognition site; other site
653938008909	dimerization interface [polypeptide binding]; other site
653938008910	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
653938008911	DNA binding site [nucleotide binding]
653938008912	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
653938008913	Uncharacterized conserved protein [Function unknown]; Region: COG2427
653938008914	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
653938008915	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
653938008916	catalytic loop [active]
653938008917	iron binding site [ion binding]; other site
653938008918	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
653938008919	4Fe-4S binding domain; Region: Fer4; pfam00037
653938008920	4Fe-4S binding domain; Region: Fer4; pfam00037
653938008921	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
653938008922	[4Fe-4S] binding site [ion binding]; other site
653938008923	molybdopterin cofactor binding site; other site
653938008924	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
653938008925	molybdopterin cofactor binding site; other site
653938008926	Uncharacterized conserved protein [Function unknown]; Region: COG1912
653938008927	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653938008928	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653938008929	putative substrate translocation pore; other site
653938008930	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
653938008931	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
653938008932	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
653938008933	active site
653938008934	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
653938008935	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
653938008936	dimer interface [polypeptide binding]; other site
653938008937	putative anticodon binding site; other site
653938008938	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
653938008939	motif 1; other site
653938008940	active site
653938008941	motif 2; other site
653938008942	motif 3; other site
653938008943	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
653938008944	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
653938008945	FMN binding site [chemical binding]; other site
653938008946	active site
653938008947	catalytic residues [active]
653938008948	substrate binding site [chemical binding]; other site
653938008949	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
653938008950	catalytic center binding site [active]
653938008951	ATP binding site [chemical binding]; other site
653938008952	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
653938008953	homooctamer interface [polypeptide binding]; other site
653938008954	active site
653938008955	dihydropteroate synthase; Region: DHPS; TIGR01496
653938008956	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
653938008957	substrate binding pocket [chemical binding]; other site
653938008958	dimer interface [polypeptide binding]; other site
653938008959	inhibitor binding site; inhibition site
653938008960	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
653938008961	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
653938008962	dimer interface [polypeptide binding]; other site
653938008963	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653938008964	catalytic residue [active]
653938008965	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
653938008966	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
653938008967	dimerization interface [polypeptide binding]; other site
653938008968	domain crossover interface; other site
653938008969	redox-dependent activation switch; other site
653938008970	pantothenate kinase; Reviewed; Region: PRK13318
653938008971	FtsH Extracellular; Region: FtsH_ext; pfam06480
653938008972	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
653938008973	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938008974	Walker A motif; other site
653938008975	ATP binding site [chemical binding]; other site
653938008976	Walker B motif; other site
653938008977	arginine finger; other site
653938008978	Peptidase family M41; Region: Peptidase_M41; pfam01434
653938008979	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
653938008980	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
653938008981	Ligand Binding Site [chemical binding]; other site
653938008982	TilS substrate C-terminal domain; Region: TilS_C; smart00977
653938008983	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
653938008984	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653938008985	active site
653938008986	hypothetical protein; Provisional; Region: PRK08582
653938008987	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
653938008988	RNA binding site [nucleotide binding]; other site
653938008989	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
653938008990	Septum formation initiator; Region: DivIC; pfam04977
653938008991	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
653938008992	RNA binding surface [nucleotide binding]; other site
653938008993	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
653938008994	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
653938008995	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
653938008996	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
653938008997	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653938008998	ATP binding site [chemical binding]; other site
653938008999	putative Mg++ binding site [ion binding]; other site
653938009000	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653938009001	nucleotide binding region [chemical binding]; other site
653938009002	ATP-binding site [chemical binding]; other site
653938009003	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
653938009004	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
653938009005	putative active site [active]
653938009006	catalytic residue [active]
653938009007	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
653938009008	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938009009	Coenzyme A binding pocket [chemical binding]; other site
653938009010	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
653938009011	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
653938009012	5S rRNA interface [nucleotide binding]; other site
653938009013	CTC domain interface [polypeptide binding]; other site
653938009014	L16 interface [polypeptide binding]; other site
653938009015	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
653938009016	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
653938009017	tetramer (dimer of dimers) interface [polypeptide binding]; other site
653938009018	NAD binding site [chemical binding]; other site
653938009019	dimer interface [polypeptide binding]; other site
653938009020	substrate binding site [chemical binding]; other site
653938009021	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
653938009022	A new structural DNA glycosylase; Region: AlkD_like; cd06561
653938009023	active site
653938009024	hypothetical protein; Provisional; Region: PRK01119
653938009025	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
653938009026	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
653938009027	Zn binding site [ion binding]; other site
653938009028	ActA Protein; Region: ActA; pfam05058
653938009029	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
653938009030	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
653938009031	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
653938009032	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
653938009033	active site
653938009034	Zn binding site [ion binding]; other site
653938009035	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
653938009036	Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137
653938009037	active site
653938009038	catalytic site [active]
653938009039	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938009040	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
653938009041	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
653938009042	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
653938009043	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
653938009044	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653938009045	active site
653938009046	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
653938009047	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
653938009048	Substrate binding site; other site
653938009049	Mg++ binding site; other site
653938009050	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
653938009051	active site
653938009052	substrate binding site [chemical binding]; other site
653938009053	CoA binding site [chemical binding]; other site
653938009054	regulatory protein SpoVG; Reviewed; Region: PRK13259
653938009055	regulatory protein SpoVG; Reviewed; Region: PRK13259
653938009056	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
653938009057	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
653938009058	FtsX-like permease family; Region: FtsX; pfam02687
653938009059	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
653938009060	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653938009061	Walker A/P-loop; other site
653938009062	ATP binding site [chemical binding]; other site
653938009063	Q-loop/lid; other site
653938009064	ABC transporter signature motif; other site
653938009065	Walker B; other site
653938009066	D-loop; other site
653938009067	H-loop/switch region; other site
653938009068	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
653938009069	HlyD family secretion protein; Region: HlyD_3; pfam13437
653938009070	pur operon repressor; Provisional; Region: PRK09213
653938009071	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
653938009072	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653938009073	active site
653938009074	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
653938009075	putative active site [active]
653938009076	YdjC motif; other site
653938009077	Mg binding site [ion binding]; other site
653938009078	putative homodimer interface [polypeptide binding]; other site
653938009079	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
653938009080	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
653938009081	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
653938009082	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
653938009083	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938009084	S-adenosylmethionine binding site [chemical binding]; other site
653938009085	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
653938009086	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
653938009087	putative active site [active]
653938009088	putative metal binding site [ion binding]; other site
653938009089	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
653938009090	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
653938009091	Domain of unknown function (DUF348); Region: DUF348; pfam03990
653938009092	Domain of unknown function (DUF348); Region: DUF348; pfam03990
653938009093	G5 domain; Region: G5; pfam07501
653938009094	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
653938009095	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
653938009096	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
653938009097	active site
653938009098	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
653938009099	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
653938009100	Ca binding site [ion binding]; other site
653938009101	active site
653938009102	catalytic site [active]
653938009103	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
653938009104	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
653938009105	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
653938009106	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
653938009107	trimer interface [polypeptide binding]; other site
653938009108	active site
653938009109	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
653938009110	catalytic site [active]
653938009111	alpha-glucosidase; Provisional; Region: PRK10426
653938009112	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
653938009113	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
653938009114	active site
653938009115	catalytic site [active]
653938009116	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
653938009117	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
653938009118	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
653938009119	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938009120	dimer interface [polypeptide binding]; other site
653938009121	conserved gate region; other site
653938009122	putative PBP binding loops; other site
653938009123	ABC-ATPase subunit interface; other site
653938009124	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
653938009125	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938009126	dimer interface [polypeptide binding]; other site
653938009127	conserved gate region; other site
653938009128	putative PBP binding loops; other site
653938009129	ABC-ATPase subunit interface; other site
653938009130	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
653938009131	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
653938009132	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
653938009133	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
653938009134	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
653938009135	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
653938009136	active site
653938009137	HIGH motif; other site
653938009138	KMSKS motif; other site
653938009139	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
653938009140	tRNA binding surface [nucleotide binding]; other site
653938009141	anticodon binding site; other site
653938009142	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
653938009143	dimer interface [polypeptide binding]; other site
653938009144	putative tRNA-binding site [nucleotide binding]; other site
653938009145	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
653938009146	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
653938009147	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938009148	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
653938009149	Integrase core domain; Region: rve; pfam00665
653938009150	Integrase core domain; Region: rve_3; cl15866
653938009151	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
653938009152	Leucine rich repeat; Region: LRR_8; pfam13855
653938009153	LRR adjacent; Region: LRR_adjacent; pfam08191
653938009154	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
653938009155	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
653938009156	Uncharacterized conserved protein [Function unknown]; Region: COG5361
653938009157	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
653938009158	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
653938009159	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
653938009160	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
653938009161	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
653938009162	Predicted methyltransferases [General function prediction only]; Region: COG0313
653938009163	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
653938009164	putative SAM binding site [chemical binding]; other site
653938009165	putative homodimer interface [polypeptide binding]; other site
653938009166	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
653938009167	GIY-YIG motif/motif A; other site
653938009168	putative active site [active]
653938009169	putative metal binding site [ion binding]; other site
653938009170	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
653938009171	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653938009172	S-adenosylmethionine binding site [chemical binding]; other site
653938009173	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467; cl01853
653938009174	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
653938009175	DNA polymerase III subunit delta'; Validated; Region: PRK08058
653938009176	DNA polymerase III subunit delta'; Validated; Region: PRK08485
653938009177	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
653938009178	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
653938009179	Collagen binding domain; Region: Collagen_bind; pfam05737
653938009180	Cna protein B-type domain; Region: Cna_B; pfam05738
653938009181	Cna protein B-type domain; Region: Cna_B; pfam05738
653938009182	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
653938009183	Collagen binding domain; Region: Collagen_bind; pfam05737
653938009184	Cna protein B-type domain; Region: Cna_B; pfam05738
653938009185	Cna protein B-type domain; Region: Cna_B; pfam05738
653938009186	Cna protein B-type domain; Region: Cna_B; pfam05738
653938009187	Cna protein B-type domain; Region: Cna_B; pfam05738
653938009188	Cna protein B-type domain; Region: Cna_B; pfam05738
653938009189	sugar phosphate phosphatase; Provisional; Region: PRK10513
653938009190	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938009191	active site
653938009192	motif I; other site
653938009193	motif II; other site
653938009194	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938009195	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
653938009196	DEAD_2; Region: DEAD_2; pfam06733
653938009197	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
653938009198	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938009199	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
653938009200	ligand binding site [chemical binding]; other site
653938009201	flexible hinge region; other site
653938009202	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
653938009203	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
653938009204	ABC-ATPase subunit  interface; other site
653938009205	dimer interface [polypeptide binding]; other site
653938009206	putative PBP binding regions; other site
653938009207	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
653938009208	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
653938009209	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
653938009210	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
653938009211	metal binding site [ion binding]; metal-binding site
653938009212	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
653938009213	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
653938009214	peptide binding site [polypeptide binding]; other site
653938009215	LXG domain of WXG superfamily; Region: LXG; pfam04740
653938009216	Protein of unknown function (DUF3130; Region: DUF3130; cl12867
653938009217	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
653938009218	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
653938009219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938009220	dimer interface [polypeptide binding]; other site
653938009221	conserved gate region; other site
653938009222	putative PBP binding loops; other site
653938009223	ABC-ATPase subunit interface; other site
653938009224	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
653938009225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653938009226	dimer interface [polypeptide binding]; other site
653938009227	conserved gate region; other site
653938009228	putative PBP binding loops; other site
653938009229	ABC-ATPase subunit interface; other site
653938009230	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
653938009231	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
653938009232	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938009233	Coenzyme A binding pocket [chemical binding]; other site
653938009234	Uncharacterized conserved protein [Function unknown]; Region: COG3592
653938009235	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107
653938009236	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
653938009237	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602
653938009238	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
653938009239	active site
653938009240	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
653938009241	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
653938009242	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
653938009243	putative active site [active]
653938009244	putative metal binding site [ion binding]; other site
653938009245	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
653938009246	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
653938009247	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
653938009248	active site
653938009249	metal binding site [ion binding]; metal-binding site
653938009250	Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824
653938009251	Predicted membrane protein [Function unknown]; Region: COG1511
653938009252	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
653938009253	Phage tail protein; Region: Sipho_tail; pfam05709
653938009254	Phage-related protein [Function unknown]; Region: COG5412
653938009255	Predicted secreted protein [Function unknown]; Region: COG5437
653938009256	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
653938009257	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938009258	non-specific DNA binding site [nucleotide binding]; other site
653938009259	salt bridge; other site
653938009260	sequence-specific DNA binding site [nucleotide binding]; other site
653938009261	Domain of unknown function (DUF955); Region: DUF955; pfam06114
653938009262	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938009263	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
653938009264	ligand binding site [chemical binding]; other site
653938009265	flexible hinge region; other site
653938009266	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
653938009267	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
653938009268	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
653938009269	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
653938009270	substrate binding pocket [chemical binding]; other site
653938009271	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
653938009272	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
653938009273	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
653938009274	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
653938009275	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
653938009276	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653938009277	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
653938009278	Walker A/P-loop; other site
653938009279	ATP binding site [chemical binding]; other site
653938009280	Q-loop/lid; other site
653938009281	ABC transporter signature motif; other site
653938009282	Walker B; other site
653938009283	D-loop; other site
653938009284	H-loop/switch region; other site
653938009285	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
653938009286	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653938009287	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
653938009288	Walker A/P-loop; other site
653938009289	ATP binding site [chemical binding]; other site
653938009290	Q-loop/lid; other site
653938009291	ABC transporter signature motif; other site
653938009292	Walker B; other site
653938009293	D-loop; other site
653938009294	H-loop/switch region; other site
653938009295	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
653938009296	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
653938009297	nucleotide binding site [chemical binding]; other site
653938009298	butyrate kinase; Region: butyr_kinase; TIGR02707
653938009299	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
653938009300	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
653938009301	active site
653938009302	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
653938009303	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
653938009304	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
653938009305	aromatic chitin/cellulose binding site residues [chemical binding]; other site
653938009306	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
653938009307	dimer interface [polypeptide binding]; other site
653938009308	FMN binding site [chemical binding]; other site
653938009309	Uncharacterized conserved protein [Function unknown]; Region: COG1359
653938009310	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
653938009311	dimerization interface [polypeptide binding]; other site
653938009312	putative DNA binding site [nucleotide binding]; other site
653938009313	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
653938009314	Domain of unknown function (DUF956); Region: DUF956; pfam06115
653938009315	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
653938009316	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
653938009317	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
653938009318	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
653938009319	active pocket/dimerization site; other site
653938009320	active site
653938009321	phosphorylation site [posttranslational modification]
653938009322	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
653938009323	active site
653938009324	phosphorylation site [posttranslational modification]
653938009325	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938009326	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823
653938009327	gamma subunit interface [polypeptide binding]; other site
653938009328	epsilon subunit interface [polypeptide binding]; other site
653938009329	LBP interface [polypeptide binding]; other site
653938009330	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
653938009331	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
653938009332	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
653938009333	alpha subunit interaction interface [polypeptide binding]; other site
653938009334	Walker A motif; other site
653938009335	ATP binding site [chemical binding]; other site
653938009336	Walker B motif; other site
653938009337	inhibitor binding site; inhibition site
653938009338	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
653938009339	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
653938009340	core domain interface [polypeptide binding]; other site
653938009341	delta subunit interface [polypeptide binding]; other site
653938009342	epsilon subunit interface [polypeptide binding]; other site
653938009343	F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343
653938009344	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
653938009345	Walker A motif; other site
653938009346	ATP binding site [chemical binding]; other site
653938009347	Walker B motif; other site
653938009348	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
653938009349	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
653938009350	ATP synthase subunit C; Region: ATP-synt_C; cl00466
653938009351	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653938009352	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
653938009353	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
653938009354	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
653938009355	active site
653938009356	catalytic tetrad [active]
653938009357	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
653938009358	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
653938009359	DNA binding residues [nucleotide binding]
653938009360	putative dimer interface [polypeptide binding]; other site
653938009361	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
653938009362	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
653938009363	NAD binding site [chemical binding]; other site
653938009364	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
653938009365	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
653938009366	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
653938009367	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
653938009368	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
653938009369	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
653938009370	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
653938009371	DNA binding site [nucleotide binding]
653938009372	active site
653938009373	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
653938009374	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
653938009375	tetramer interface [polypeptide binding]; other site
653938009376	active site
653938009377	Mg2+/Mn2+ binding site [ion binding]; other site
653938009378	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
653938009379	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
653938009380	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
653938009381	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
653938009382	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
653938009383	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868
653938009384	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
653938009385	Uncharacterized small protein [Function unknown]; Region: COG5417
653938009386	WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266
653938009387	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
653938009388	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
653938009389	Predicted membrane protein [Function unknown]; Region: COG1511
653938009390	Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858
653938009391	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
653938009392	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
653938009393	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
653938009394	GDP-binding site [chemical binding]; other site
653938009395	ACT binding site; other site
653938009396	IMP binding site; other site
653938009397	replicative DNA helicase; Provisional; Region: PRK05748
653938009398	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
653938009399	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
653938009400	Walker A motif; other site
653938009401	ATP binding site [chemical binding]; other site
653938009402	Walker B motif; other site
653938009403	DNA binding loops [nucleotide binding]
653938009404	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
653938009405	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
653938009406	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
653938009407	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
653938009408	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
653938009409	DHH family; Region: DHH; pfam01368
653938009410	DHHA1 domain; Region: DHHA1; pfam02272
653938009411	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
653938009412	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653938009413	active site
653938009414	phosphorylation site [posttranslational modification]
653938009415	intermolecular recognition site; other site
653938009416	LytTr DNA-binding domain; Region: LytTR; pfam04397
653938009417	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
653938009418	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938009419	ATP binding site [chemical binding]; other site
653938009420	Mg2+ binding site [ion binding]; other site
653938009421	G-X-G motif; other site
653938009422	Staphylococcal AgrD protein; Region: AgrD; cl05477
653938009423	putative accessory gene regulator protein; Provisional; Region: PRK01100
653938009424	Predicted membrane protein [Function unknown]; Region: COG3212
653938009425	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
653938009426	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
653938009427	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
653938009428	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
653938009429	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
653938009430	dimer interface [polypeptide binding]; other site
653938009431	ssDNA binding site [nucleotide binding]; other site
653938009432	tetramer (dimer of dimers) interface [polypeptide binding]; other site
653938009433	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
653938009434	arginine deiminase; Provisional; Region: PRK01388
653938009435	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
653938009436	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
653938009437	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
653938009438	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
653938009439	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
653938009440	putative active site [active]
653938009441	agmatine deiminase; Provisional; Region: PRK13551
653938009442	agmatine deiminase; Region: agmatine_aguA; TIGR03380
653938009443	carbamate kinase; Reviewed; Region: PRK12686
653938009444	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
653938009445	putative substrate binding site [chemical binding]; other site
653938009446	nucleotide binding site [chemical binding]; other site
653938009447	nucleotide binding site [chemical binding]; other site
653938009448	homodimer interface [polypeptide binding]; other site
653938009449	agmatine deiminase; Provisional; Region: PRK13551
653938009450	agmatine deiminase; Region: agmatine_aguA; TIGR03380
653938009451	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
653938009452	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
653938009453	putrescine carbamoyltransferase; Provisional; Region: PRK02255
653938009454	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
653938009455	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
653938009456	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
653938009457	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
653938009458	dimer interface [polypeptide binding]; other site
653938009459	active site
653938009460	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
653938009461	dimer interface [polypeptide binding]; other site
653938009462	active site
653938009463	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
653938009464	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
653938009465	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
653938009466	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
653938009467	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
653938009468	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
653938009469	nucleotide binding site [chemical binding]; other site
653938009470	Butyrate kinase [Energy production and conversion]; Region: COG3426
653938009471	Transcriptional regulators [Transcription]; Region: PurR; COG1609
653938009472	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
653938009473	DNA binding site [nucleotide binding]
653938009474	domain linker motif; other site
653938009475	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
653938009476	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
653938009477	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938009478	active site
653938009479	motif I; other site
653938009480	motif II; other site
653938009481	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653938009482	Protein of unknown function (DUF2712); Region: DUF2712; pfam10916
653938009483	Protein of unknown function (DUF2705); Region: DUF2705; pfam10920
653938009484	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
653938009485	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938009486	Walker A/P-loop; other site
653938009487	ATP binding site [chemical binding]; other site
653938009488	Q-loop/lid; other site
653938009489	ABC transporter signature motif; other site
653938009490	Walker B; other site
653938009491	D-loop; other site
653938009492	H-loop/switch region; other site
653938009493	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
653938009494	putative dimer interface [polypeptide binding]; other site
653938009495	catalytic triad [active]
653938009496	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
653938009497	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
653938009498	active site turn [active]
653938009499	phosphorylation site [posttranslational modification]
653938009500	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
653938009501	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
653938009502	HPr interaction site; other site
653938009503	glycerol kinase (GK) interaction site [polypeptide binding]; other site
653938009504	active site
653938009505	phosphorylation site [posttranslational modification]
653938009506	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
653938009507	hypothetical protein; Provisional; Region: PRK02947
653938009508	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
653938009509	putative active site [active]
653938009510	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
653938009511	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
653938009512	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
653938009513	active site
653938009514	phosphorylation site [posttranslational modification]
653938009515	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
653938009516	active site
653938009517	active pocket/dimerization site; other site
653938009518	phosphorylation site [posttranslational modification]
653938009519	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
653938009520	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653938009521	DNA-binding site [nucleotide binding]; DNA binding site
653938009522	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
653938009523	Bacterial SH3 domain; Region: SH3_3; pfam08239
653938009524	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
653938009525	putative active site [active]
653938009526	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
653938009527	beta-galactosidase; Region: BGL; TIGR03356
653938009528	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
653938009529	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
653938009530	putative active site [active]
653938009531	putative metal binding site [ion binding]; other site
653938009532	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
653938009533	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
653938009534	Subunit I/III interface [polypeptide binding]; other site
653938009535	Subunit III/IV interface [polypeptide binding]; other site
653938009536	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
653938009537	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
653938009538	D-pathway; other site
653938009539	Putative ubiquinol binding site [chemical binding]; other site
653938009540	Low-spin heme (heme b) binding site [chemical binding]; other site
653938009541	Putative water exit pathway; other site
653938009542	Binuclear center (heme o3/CuB) [ion binding]; other site
653938009543	K-pathway; other site
653938009544	Putative proton exit pathway; other site
653938009545	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
653938009546	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
653938009547	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
653938009548	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
653938009549	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
653938009550	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
653938009551	diphosphomevalonate decarboxylase; Region: PLN02407
653938009552	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
653938009553	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
653938009554	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
653938009555	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
653938009556	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653938009557	Coenzyme A binding pocket [chemical binding]; other site
653938009558	cardiolipin synthetase; Reviewed; Region: PRK12452
653938009559	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
653938009560	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
653938009561	putative active site [active]
653938009562	catalytic site [active]
653938009563	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
653938009564	putative active site [active]
653938009565	catalytic site [active]
653938009566	DNA gyrase subunit A; Validated; Region: PRK05560
653938009567	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
653938009568	CAP-like domain; other site
653938009569	active site
653938009570	primary dimer interface [polypeptide binding]; other site
653938009571	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
653938009572	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
653938009573	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
653938009574	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
653938009575	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
653938009576	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
653938009577	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653938009578	Mg2+ binding site [ion binding]; other site
653938009579	G-X-G motif; other site
653938009580	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
653938009581	anchoring element; other site
653938009582	dimer interface [polypeptide binding]; other site
653938009583	ATP binding site [chemical binding]; other site
653938009584	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
653938009585	active site
653938009586	putative metal-binding site [ion binding]; other site
653938009587	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
653938009588	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
653938009589	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
653938009590	Walker A/P-loop; other site
653938009591	ATP binding site [chemical binding]; other site
653938009592	Q-loop/lid; other site
653938009593	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653938009594	ABC transporter signature motif; other site
653938009595	Walker B; other site
653938009596	D-loop; other site
653938009597	H-loop/switch region; other site
653938009598	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
653938009599	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
653938009600	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
653938009601	DNA polymerase III subunit beta; Validated; Region: PRK05643
653938009602	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
653938009603	putative DNA binding surface [nucleotide binding]; other site
653938009604	dimer interface [polypeptide binding]; other site
653938009605	beta-clamp/clamp loader binding surface; other site
653938009606	beta-clamp/translesion DNA polymerase binding surface; other site
653938009607	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
653938009608	DnaA N-terminal domain; Region: DnaA_N; pfam11638
653938009609	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938009610	Walker A motif; other site
653938009611	ATP binding site [chemical binding]; other site
653938009612	Walker B motif; other site
653938009613	arginine finger; other site
653938009614	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
653938009615	DnaA box-binding interface [nucleotide binding]; other site
653938009616	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
653938009617	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
653938009618	Soluble P-type ATPase [General function prediction only]; Region: COG4087
653938009619	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
653938009620	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
653938009621	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
653938009622	multiple promoter invertase; Provisional; Region: mpi; PRK13413
653938009623	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
653938009624	catalytic residues [active]
653938009625	catalytic nucleophile [active]
653938009626	Presynaptic Site I dimer interface [polypeptide binding]; other site
653938009627	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
653938009628	Synaptic Flat tetramer interface [polypeptide binding]; other site
653938009629	Synaptic Site I dimer interface [polypeptide binding]; other site
653938009630	DNA binding site [nucleotide binding]
653938009631	Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
653938009632	DNA-binding interface [nucleotide binding]; DNA binding site
653938009633	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
653938009634	dimerization interface [polypeptide binding]; other site
653938009635	putative DNA binding site [nucleotide binding]; other site
653938009636	putative Zn2+ binding site [ion binding]; other site
653938009637	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
653938009638	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
653938009639	metal-binding site [ion binding]
653938009640	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
653938009641	Soluble P-type ATPase [General function prediction only]; Region: COG4087
653938009642	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
653938009643	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
653938009644	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
653938009645	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
653938009646	multiple promoter invertase; Provisional; Region: mpi; PRK13413
653938009647	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
653938009648	catalytic residues [active]
653938009649	catalytic nucleophile [active]
653938009650	Presynaptic Site I dimer interface [polypeptide binding]; other site
653938009651	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
653938009652	Synaptic Flat tetramer interface [polypeptide binding]; other site
653938009653	Synaptic Site I dimer interface [polypeptide binding]; other site
653938009654	DNA binding site [nucleotide binding]
653938009655	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938009656	non-specific DNA binding site [nucleotide binding]; other site
653938009657	salt bridge; other site
653938009658	sequence-specific DNA binding site [nucleotide binding]; other site
653938009659	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938009660	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
653938009661	Walker A motif; other site
653938009662	ATP binding site [chemical binding]; other site
653938009663	Walker B motif; other site
653938009664	arginine finger; other site
653938009665	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653938009666	Walker A motif; other site
653938009667	ATP binding site [chemical binding]; other site
653938009668	Walker B motif; other site
653938009669	arginine finger; other site
653938009670	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
653938009671	Helix-turn-helix domain; Region: HTH_28; pfam13518
653938009672	putative transposase OrfB; Reviewed; Region: PHA02517
653938009673	HTH-like domain; Region: HTH_21; pfam13276
653938009674	Integrase core domain; Region: rve; pfam00665
653938009675	Integrase core domain; Region: rve_2; pfam13333
653938009676	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
653938009677	P-loop; other site
653938009678	Magnesium ion binding site [ion binding]; other site
653938009679	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
653938009680	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
653938009681	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
653938009682	active site
653938009683	DNA binding site [nucleotide binding]
653938009684	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
653938009685	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
653938009686	P-loop; other site
653938009687	Magnesium ion binding site [ion binding]; other site
653938009688	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
653938009689	Magnesium ion binding site [ion binding]; other site
653938009690	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
653938009691	WxL domain surface cell wall-binding; Region: WxL; pfam13731
653938009692	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
653938009693	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
653938009694	Organic Anion Transporter Polypeptide (OATP) family; Region: OATP; pfam03137
653938009695	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
653938009696	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
653938009697	Walker A motif; other site
653938009698	ATP binding site [chemical binding]; other site
653938009699	Walker B motif; other site
653938009700	Protein of unknown function (DUF669); Region: DUF669; pfam05037
653938009701	CAAX protease self-immunity; Region: Abi; pfam02517
653938009702	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
653938009703	DNA topoisomerase III; Provisional; Region: PRK07726
653938009704	active site
653938009705	putative interdomain interaction site [polypeptide binding]; other site
653938009706	putative metal-binding site [ion binding]; other site
653938009707	putative nucleotide binding site [chemical binding]; other site
653938009708	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
653938009709	domain I; other site
653938009710	DNA binding groove [nucleotide binding]
653938009711	phosphate binding site [ion binding]; other site
653938009712	domain II; other site
653938009713	domain III; other site
653938009714	nucleotide binding site [chemical binding]; other site
653938009715	catalytic site [active]
653938009716	domain IV; other site
653938009717	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
653938009718	Toprim-like; Region: Toprim_2; pfam13155
653938009719	active site
653938009720	metal binding site [ion binding]; metal-binding site
653938009721	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
653938009722	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
653938009723	Walker A motif; other site
653938009724	ATP binding site [chemical binding]; other site
653938009725	Walker B motif; other site
653938009726	BDLF3; Provisional; Region: PHA03255
653938009727	AAA-like domain; Region: AAA_10; pfam12846
653938009728	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
653938009729	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
653938009730	NlpC/P60 family; Region: NLPC_P60; pfam00877
653938009731	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
653938009732	Fic family protein [Function unknown]; Region: COG3177
653938009733	Fic/DOC family; Region: Fic; pfam02661
653938009734	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653938009735	non-specific DNA binding site [nucleotide binding]; other site
653938009736	salt bridge; other site
653938009737	sequence-specific DNA binding site [nucleotide binding]; other site
653938009738	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
653938009739	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
653938009740	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
653938009741	Integrase core domain; Region: rve; pfam00665
653938009742	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
653938009743	Integrase core domain; Region: rve; pfam00665
653938009744	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
653938009745	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653938009746	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
653938009747	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
653938009748	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
653938009749	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
653938009750	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
653938009751	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
653938009752	Soluble P-type ATPase [General function prediction only]; Region: COG4087
653938009753	Integrase core domain; Region: rve; pfam00665
653938009754	DDE domain; Region: DDE_Tnp_IS240; pfam13610
653938009755	Domain of unknown function DUF87; Region: DUF87; pfam01935
653938009756	HerA helicase [Replication, recombination, and repair]; Region: COG0433
653938009757	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
653938009758	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
653938009759	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
653938009760	catalytic residues [active]
653938009761	catalytic nucleophile [active]
653938009762	Presynaptic Site I dimer interface [polypeptide binding]; other site
653938009763	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
653938009764	Synaptic Flat tetramer interface [polypeptide binding]; other site
653938009765	Synaptic Site I dimer interface [polypeptide binding]; other site
653938009766	DNA binding site [nucleotide binding]
653938009767	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
653938009768	DNA-binding interface [nucleotide binding]; DNA binding site