-- dump date 20140619_134540 -- class Genbank::misc_feature -- table misc_feature_note -- id note 683837000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 683837000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 683837000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837000004 Walker A motif; other site 683837000005 ATP binding site [chemical binding]; other site 683837000006 Walker B motif; other site 683837000007 arginine finger; other site 683837000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 683837000009 DnaA box-binding interface [nucleotide binding]; other site 683837000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 683837000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 683837000012 putative DNA binding surface [nucleotide binding]; other site 683837000013 dimer interface [polypeptide binding]; other site 683837000014 beta-clamp/clamp loader binding surface; other site 683837000015 beta-clamp/translesion DNA polymerase binding surface; other site 683837000016 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 683837000017 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 683837000018 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 683837000019 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 683837000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 683837000021 Walker A/P-loop; other site 683837000022 ATP binding site [chemical binding]; other site 683837000023 Q-loop/lid; other site 683837000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837000025 ABC transporter signature motif; other site 683837000026 Walker B; other site 683837000027 D-loop; other site 683837000028 H-loop/switch region; other site 683837000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 683837000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837000031 Mg2+ binding site [ion binding]; other site 683837000032 G-X-G motif; other site 683837000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 683837000034 anchoring element; other site 683837000035 dimer interface [polypeptide binding]; other site 683837000036 ATP binding site [chemical binding]; other site 683837000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 683837000038 active site 683837000039 putative metal-binding site [ion binding]; other site 683837000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 683837000041 DNA gyrase subunit A; Validated; Region: PRK05560 683837000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 683837000043 CAP-like domain; other site 683837000044 active site 683837000045 primary dimer interface [polypeptide binding]; other site 683837000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 683837000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 683837000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 683837000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 683837000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 683837000051 cardiolipin synthetase; Reviewed; Region: PRK12452 683837000052 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 683837000053 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 683837000054 putative active site [active] 683837000055 catalytic site [active] 683837000056 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 683837000057 putative active site [active] 683837000058 catalytic site [active] 683837000059 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 683837000060 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 683837000061 Coenzyme A binding pocket [chemical binding]; other site 683837000062 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 683837000063 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 683837000064 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 683837000065 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 683837000066 diphosphomevalonate decarboxylase; Region: PLN02407 683837000067 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 683837000068 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 683837000069 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 683837000070 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 683837000071 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 683837000072 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 683837000073 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 683837000074 D-pathway; other site 683837000075 Putative ubiquinol binding site [chemical binding]; other site 683837000076 Low-spin heme (heme b) binding site [chemical binding]; other site 683837000077 Putative water exit pathway; other site 683837000078 Binuclear center (heme o3/CuB) [ion binding]; other site 683837000079 K-pathway; other site 683837000080 Putative proton exit pathway; other site 683837000081 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 683837000082 Subunit I/III interface [polypeptide binding]; other site 683837000083 Subunit III/IV interface [polypeptide binding]; other site 683837000084 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 683837000085 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 683837000086 beta-galactosidase; Region: BGL; TIGR03356 683837000087 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 683837000088 Bacterial SH3 domain; Region: SH3_3; pfam08239 683837000089 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 683837000090 putative active site [active] 683837000091 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 683837000092 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 683837000093 active site turn [active] 683837000094 phosphorylation site [posttranslational modification] 683837000095 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 683837000096 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 683837000097 HPr interaction site; other site 683837000098 glycerol kinase (GK) interaction site [polypeptide binding]; other site 683837000099 active site 683837000100 phosphorylation site [posttranslational modification] 683837000101 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 683837000102 putative dimer interface [polypeptide binding]; other site 683837000103 catalytic triad [active] 683837000104 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 683837000105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837000106 Walker A/P-loop; other site 683837000107 ATP binding site [chemical binding]; other site 683837000108 Q-loop/lid; other site 683837000109 ABC transporter signature motif; other site 683837000110 Walker B; other site 683837000111 D-loop; other site 683837000112 H-loop/switch region; other site 683837000113 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 683837000116 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 683837000117 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 683837000118 arginine deiminase; Provisional; Region: PRK01388 683837000119 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 683837000120 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 683837000121 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 683837000122 dimer interface [polypeptide binding]; other site 683837000123 ssDNA binding site [nucleotide binding]; other site 683837000124 tetramer (dimer of dimers) interface [polypeptide binding]; other site 683837000125 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 683837000126 Predicted membrane protein [Function unknown]; Region: COG3212 683837000127 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 683837000128 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 683837000129 putative accessory gene regulator protein; Provisional; Region: PRK01100 683837000130 Staphylococcal AgrD protein; Region: AgrD; cl05477 683837000131 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 683837000132 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 683837000133 ATP binding site [chemical binding]; other site 683837000134 Mg2+ binding site [ion binding]; other site 683837000135 G-X-G motif; other site 683837000136 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 683837000137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837000138 active site 683837000139 phosphorylation site [posttranslational modification] 683837000140 intermolecular recognition site; other site 683837000141 dimerization interface [polypeptide binding]; other site 683837000142 LytTr DNA-binding domain; Region: LytTR; pfam04397 683837000143 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 683837000144 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 683837000145 DHH family; Region: DHH; pfam01368 683837000146 DHHA1 domain; Region: DHHA1; pfam02272 683837000147 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 683837000148 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 683837000149 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 683837000150 replicative DNA helicase; Provisional; Region: PRK05748 683837000151 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 683837000152 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 683837000153 Walker A motif; other site 683837000154 ATP binding site [chemical binding]; other site 683837000155 Walker B motif; other site 683837000156 DNA binding loops [nucleotide binding] 683837000157 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 683837000158 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 683837000159 GDP-binding site [chemical binding]; other site 683837000160 ACT binding site; other site 683837000161 IMP binding site; other site 683837000162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 683837000163 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 683837000164 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 683837000165 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 683837000166 Uncharacterized small protein [Function unknown]; Region: COG5417 683837000167 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 683837000168 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 683837000169 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 683837000170 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 683837000171 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 683837000172 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 683837000173 LXG domain of WXG superfamily; Region: LXG; pfam04740 683837000174 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 683837000175 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 683837000176 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 683837000177 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 683837000178 LXG domain of WXG superfamily; Region: LXG; pfam04740 683837000179 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 683837000180 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 683837000181 tetramer interface [polypeptide binding]; other site 683837000182 active site 683837000183 Mg2+/Mn2+ binding site [ion binding]; other site 683837000184 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 683837000185 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 683837000186 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 683837000187 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 683837000188 DNA binding site [nucleotide binding] 683837000189 active site 683837000190 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 683837000191 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 683837000192 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 683837000193 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 683837000194 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 683837000195 NAD binding site [chemical binding]; other site 683837000196 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 683837000197 LXG domain of WXG superfamily; Region: LXG; pfam04740 683837000198 LXG domain of WXG superfamily; Region: LXG; pfam04740 683837000199 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 683837000200 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837000201 LRR adjacent; Region: LRR_adjacent; pfam08191 683837000202 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 683837000203 Leucine rich repeat; Region: LRR_8; pfam13855 683837000204 LRR adjacent; Region: LRR_adjacent; pfam08191 683837000205 SH3-like domain; Region: SH3_8; pfam13457 683837000206 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 683837000207 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 683837000208 active pocket/dimerization site; other site 683837000209 active site 683837000210 phosphorylation site [posttranslational modification] 683837000211 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 683837000212 active site 683837000213 phosphorylation site [posttranslational modification] 683837000214 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 683837000215 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 683837000216 Domain of unknown function (DUF956); Region: DUF956; pfam06115 683837000217 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 683837000218 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 683837000219 dimerization interface [polypeptide binding]; other site 683837000220 putative DNA binding site [nucleotide binding]; other site 683837000221 Uncharacterized conserved protein [Function unknown]; Region: COG1359 683837000222 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 683837000223 dimer interface [polypeptide binding]; other site 683837000224 FMN binding site [chemical binding]; other site 683837000225 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 683837000226 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 683837000227 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 683837000228 putative active site [active] 683837000229 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 683837000230 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 683837000231 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 683837000232 active site turn [active] 683837000233 phosphorylation site [posttranslational modification] 683837000234 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 683837000235 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 683837000236 NAD binding site [chemical binding]; other site 683837000237 sugar binding site [chemical binding]; other site 683837000238 divalent metal binding site [ion binding]; other site 683837000239 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 683837000240 dimer interface [polypeptide binding]; other site 683837000241 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 683837000242 HPr interaction site; other site 683837000243 glycerol kinase (GK) interaction site [polypeptide binding]; other site 683837000244 active site 683837000245 phosphorylation site [posttranslational modification] 683837000246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837000247 oligosaccharide:H+ symporter; Region: 2A0105; TIGR00882 683837000248 putative substrate translocation pore; other site 683837000249 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 683837000250 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 683837000251 active site 683837000252 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 683837000253 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 683837000254 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 683837000255 aromatic chitin/cellulose binding site residues [chemical binding]; other site 683837000256 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 683837000257 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 683837000258 nucleotide binding site [chemical binding]; other site 683837000259 WxL domain surface cell wall-binding; Region: WxL; pfam13731 683837000260 WxL domain surface cell wall-binding; Region: WxL; pfam13731 683837000261 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 683837000262 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 683837000263 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 683837000264 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 683837000265 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 683837000266 Walker A/P-loop; other site 683837000267 ATP binding site [chemical binding]; other site 683837000268 Q-loop/lid; other site 683837000269 ABC transporter signature motif; other site 683837000270 Walker B; other site 683837000271 D-loop; other site 683837000272 H-loop/switch region; other site 683837000273 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 683837000274 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 683837000275 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 683837000276 Walker A/P-loop; other site 683837000277 ATP binding site [chemical binding]; other site 683837000278 Q-loop/lid; other site 683837000279 ABC transporter signature motif; other site 683837000280 Walker B; other site 683837000281 D-loop; other site 683837000282 H-loop/switch region; other site 683837000283 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 683837000284 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 683837000285 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 683837000286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 683837000287 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 683837000288 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 683837000289 substrate binding pocket [chemical binding]; other site 683837000290 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 683837000291 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 683837000292 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 683837000293 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 683837000294 ligand binding site [chemical binding]; other site 683837000295 flexible hinge region; other site 683837000296 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 683837000297 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 683837000298 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 683837000299 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 683837000300 DNA binding residues [nucleotide binding] 683837000301 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 683837000302 Domain of unknown function (DUF955); Region: DUF955; pfam06114 683837000303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837000304 non-specific DNA binding site [nucleotide binding]; other site 683837000305 salt bridge; other site 683837000306 sequence-specific DNA binding site [nucleotide binding]; other site 683837000307 Holin family; Region: Phage_holin_4; cl01989 683837000308 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 683837000309 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 683837000310 putative active site [active] 683837000311 putative metal binding site [ion binding]; other site 683837000312 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 683837000313 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 683837000314 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 683837000315 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 683837000316 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 683837000317 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 683837000318 active site 683837000319 Uncharacterized conserved protein [Function unknown]; Region: COG3592 683837000320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 683837000321 Coenzyme A binding pocket [chemical binding]; other site 683837000322 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 683837000323 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 683837000324 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 683837000325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837000326 dimer interface [polypeptide binding]; other site 683837000327 conserved gate region; other site 683837000328 putative PBP binding loops; other site 683837000329 ABC-ATPase subunit interface; other site 683837000330 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 683837000331 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 683837000332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837000333 dimer interface [polypeptide binding]; other site 683837000334 conserved gate region; other site 683837000335 putative PBP binding loops; other site 683837000336 ABC-ATPase subunit interface; other site 683837000337 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 683837000338 peptide binding site [polypeptide binding]; other site 683837000339 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 683837000340 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 683837000341 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 683837000342 metal binding site [ion binding]; metal-binding site 683837000343 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 683837000344 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 683837000345 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 683837000346 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 683837000347 ABC-ATPase subunit interface; other site 683837000348 dimer interface [polypeptide binding]; other site 683837000349 putative PBP binding regions; other site 683837000350 DNA repair helicase (rad3); Region: rad3; TIGR00604 683837000351 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 683837000352 DEAD_2; Region: DEAD_2; pfam06733 683837000353 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 683837000354 sugar phosphate phosphatase; Provisional; Region: PRK10513 683837000355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837000356 active site 683837000357 motif I; other site 683837000358 motif II; other site 683837000359 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837000360 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 683837000361 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 683837000362 active site 683837000363 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 683837000364 NlpC/P60 family; Region: NLPC_P60; pfam00877 683837000365 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 683837000366 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 683837000367 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 683837000368 peptide binding site [polypeptide binding]; other site 683837000369 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 683837000370 SxDxEG motif; other site 683837000371 active site 683837000372 metal binding site [ion binding]; metal-binding site 683837000373 homopentamer interface [polypeptide binding]; other site 683837000374 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 683837000375 Collagen binding domain; Region: Collagen_bind; pfam05737 683837000376 Cna protein B-type domain; Region: Cna_B; pfam05738 683837000377 Cna protein B-type domain; Region: Cna_B; pfam05738 683837000378 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 683837000379 DNA polymerase III subunit delta'; Validated; Region: PRK08058 683837000380 DNA polymerase III subunit delta'; Validated; Region: PRK08485 683837000381 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 683837000382 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 683837000383 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 683837000384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837000385 S-adenosylmethionine binding site [chemical binding]; other site 683837000386 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 683837000387 GIY-YIG motif/motif A; other site 683837000388 putative active site [active] 683837000389 putative metal binding site [ion binding]; other site 683837000390 Predicted methyltransferases [General function prediction only]; Region: COG0313 683837000391 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 683837000392 putative SAM binding site [chemical binding]; other site 683837000393 putative homodimer interface [polypeptide binding]; other site 683837000394 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 683837000395 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 683837000396 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 683837000397 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 683837000398 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 683837000399 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 683837000400 active site 683837000401 HIGH motif; other site 683837000402 KMSKS motif; other site 683837000403 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 683837000404 tRNA binding surface [nucleotide binding]; other site 683837000405 anticodon binding site; other site 683837000406 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 683837000407 dimer interface [polypeptide binding]; other site 683837000408 putative tRNA-binding site [nucleotide binding]; other site 683837000409 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 683837000410 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 683837000411 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 683837000412 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 683837000413 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 683837000414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837000415 dimer interface [polypeptide binding]; other site 683837000416 conserved gate region; other site 683837000417 putative PBP binding loops; other site 683837000418 ABC-ATPase subunit interface; other site 683837000419 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 683837000420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837000421 dimer interface [polypeptide binding]; other site 683837000422 conserved gate region; other site 683837000423 putative PBP binding loops; other site 683837000424 ABC-ATPase subunit interface; other site 683837000425 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 683837000426 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 683837000427 alpha-glucosidase; Provisional; Region: PRK10426 683837000428 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 683837000429 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 683837000430 active site 683837000431 catalytic site [active] 683837000432 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 683837000433 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 683837000434 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 683837000435 trimer interface [polypeptide binding]; other site 683837000436 active site 683837000437 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 683837000438 catalytic site [active] 683837000439 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 683837000440 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 683837000441 Ca binding site [ion binding]; other site 683837000442 active site 683837000443 catalytic site [active] 683837000444 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 683837000445 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 683837000446 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 683837000447 active site 683837000448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 683837000449 Domain of unknown function (DUF348); Region: DUF348; pfam03990 683837000450 Domain of unknown function (DUF348); Region: DUF348; pfam03990 683837000451 Domain of unknown function (DUF348); Region: DUF348; pfam03990 683837000452 G5 domain; Region: G5; pfam07501 683837000453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 683837000454 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 683837000455 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 683837000456 putative active site [active] 683837000457 putative metal binding site [ion binding]; other site 683837000458 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 683837000459 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 683837000460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837000461 S-adenosylmethionine binding site [chemical binding]; other site 683837000462 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 683837000463 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 683837000464 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 683837000465 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 683837000466 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 683837000467 putative active site [active] 683837000468 YdjC motif; other site 683837000469 Mg binding site [ion binding]; other site 683837000470 putative homodimer interface [polypeptide binding]; other site 683837000471 pur operon repressor; Provisional; Region: PRK09213 683837000472 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 683837000473 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 683837000474 active site 683837000475 HlyD family secretion protein; Region: HlyD_3; pfam13437 683837000476 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 683837000477 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 683837000478 Walker A/P-loop; other site 683837000479 ATP binding site [chemical binding]; other site 683837000480 Q-loop/lid; other site 683837000481 ABC transporter signature motif; other site 683837000482 Walker B; other site 683837000483 D-loop; other site 683837000484 H-loop/switch region; other site 683837000485 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 683837000486 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 683837000487 FtsX-like permease family; Region: FtsX; pfam02687 683837000488 regulatory protein SpoVG; Reviewed; Region: PRK13259 683837000489 regulatory protein SpoVG; Reviewed; Region: PRK13259 683837000490 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 683837000491 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 683837000492 Substrate binding site; other site 683837000493 Mg++ binding site; other site 683837000494 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 683837000495 active site 683837000496 substrate binding site [chemical binding]; other site 683837000497 CoA binding site [chemical binding]; other site 683837000498 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 683837000499 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 683837000500 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 683837000501 active site 683837000502 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 683837000503 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 683837000504 intersubunit interface [polypeptide binding]; other site 683837000505 active site 683837000506 Zn2+ binding site [ion binding]; other site 683837000507 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 683837000508 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 683837000509 ligand binding site [chemical binding]; other site 683837000510 flexible hinge region; other site 683837000511 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 683837000512 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 683837000513 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 683837000514 active site 683837000515 catalytic site [active] 683837000516 putative metal binding site [ion binding]; other site 683837000517 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 683837000518 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 683837000519 catalytic site [active] 683837000520 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 683837000521 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 683837000522 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 683837000523 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 683837000524 active site 683837000525 Zn binding site [ion binding]; other site 683837000526 ActA Protein; Region: ActA; pfam05058 683837000527 ActA Protein; Region: ActA; pfam05058 683837000530 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 683837000531 Zn binding site [ion binding]; other site 683837000532 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837000533 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837000534 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837000535 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837000536 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837000537 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 683837000538 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 683837000539 active site 683837000540 metal binding site [ion binding]; metal-binding site 683837000541 hypothetical protein; Provisional; Region: PRK01119 683837000542 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 683837000543 A new structural DNA glycosylase; Region: AlkD_like; cd06561 683837000544 active site 683837000545 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 683837000546 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 683837000547 tetramer (dimer of dimers) interface [polypeptide binding]; other site 683837000548 NAD binding site [chemical binding]; other site 683837000549 dimer interface [polypeptide binding]; other site 683837000550 substrate binding site [chemical binding]; other site 683837000551 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 683837000552 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 683837000553 5S rRNA interface [nucleotide binding]; other site 683837000554 CTC domain interface [polypeptide binding]; other site 683837000555 L16 interface [polypeptide binding]; other site 683837000556 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 683837000557 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 683837000558 Coenzyme A binding pocket [chemical binding]; other site 683837000559 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 683837000560 putative active site [active] 683837000561 catalytic residue [active] 683837000562 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 683837000563 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 683837000564 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 683837000565 ATP binding site [chemical binding]; other site 683837000566 putative Mg++ binding site [ion binding]; other site 683837000567 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 683837000568 nucleotide binding region [chemical binding]; other site 683837000569 ATP-binding site [chemical binding]; other site 683837000570 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 683837000571 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 683837000572 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 683837000573 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 683837000574 RNA binding surface [nucleotide binding]; other site 683837000575 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 683837000576 Septum formation initiator; Region: DivIC; pfam04977 683837000577 hypothetical protein; Provisional; Region: PRK08582 683837000578 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 683837000579 RNA binding site [nucleotide binding]; other site 683837000580 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 683837000581 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 683837000582 Ligand Binding Site [chemical binding]; other site 683837000583 TilS substrate C-terminal domain; Region: TilS_C; smart00977 683837000584 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 683837000585 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 683837000586 active site 683837000587 FtsH Extracellular; Region: FtsH_ext; pfam06480 683837000588 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 683837000589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837000590 Walker A motif; other site 683837000591 ATP binding site [chemical binding]; other site 683837000592 Walker B motif; other site 683837000593 arginine finger; other site 683837000594 Peptidase family M41; Region: Peptidase_M41; pfam01434 683837000595 pantothenate kinase; Reviewed; Region: PRK13318 683837000596 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 683837000597 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 683837000598 dimerization interface [polypeptide binding]; other site 683837000599 domain crossover interface; other site 683837000600 redox-dependent activation switch; other site 683837000601 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 683837000602 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 683837000603 dimer interface [polypeptide binding]; other site 683837000604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837000605 catalytic residue [active] 683837000606 dihydropteroate synthase; Region: DHPS; TIGR01496 683837000607 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 683837000608 substrate binding pocket [chemical binding]; other site 683837000609 dimer interface [polypeptide binding]; other site 683837000610 inhibitor binding site; inhibition site 683837000611 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 683837000612 homooctamer interface [polypeptide binding]; other site 683837000613 active site 683837000614 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 683837000615 catalytic center binding site [active] 683837000616 ATP binding site [chemical binding]; other site 683837000617 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 683837000618 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 683837000619 FMN binding site [chemical binding]; other site 683837000620 active site 683837000621 catalytic residues [active] 683837000622 substrate binding site [chemical binding]; other site 683837000623 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 683837000624 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 683837000625 dimer interface [polypeptide binding]; other site 683837000626 putative anticodon binding site; other site 683837000627 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 683837000628 motif 1; other site 683837000629 active site 683837000630 motif 2; other site 683837000631 motif 3; other site 683837000632 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 683837000633 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 683837000634 UvrB/uvrC motif; Region: UVR; pfam02151 683837000635 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 683837000636 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 683837000637 ADP binding site [chemical binding]; other site 683837000638 phosphagen binding site; other site 683837000639 substrate specificity loop; other site 683837000640 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 683837000641 Clp amino terminal domain; Region: Clp_N; pfam02861 683837000642 Clp amino terminal domain; Region: Clp_N; pfam02861 683837000643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837000644 Walker A motif; other site 683837000645 ATP binding site [chemical binding]; other site 683837000646 Walker B motif; other site 683837000647 arginine finger; other site 683837000648 UvrB/uvrC motif; Region: UVR; pfam02151 683837000649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837000650 Walker A motif; other site 683837000651 ATP binding site [chemical binding]; other site 683837000652 Walker B motif; other site 683837000653 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 683837000654 DNA repair protein RadA; Provisional; Region: PRK11823 683837000655 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 683837000656 Walker A motif/ATP binding site; other site 683837000657 ATP binding site [chemical binding]; other site 683837000658 Walker B motif; other site 683837000659 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 683837000660 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 683837000661 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 683837000662 putative active site [active] 683837000663 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 683837000664 substrate binding site; other site 683837000665 dimer interface; other site 683837000666 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 683837000667 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 683837000668 HIGH motif; other site 683837000669 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 683837000670 active site 683837000671 KMSKS motif; other site 683837000672 serine O-acetyltransferase; Region: cysE; TIGR01172 683837000673 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 683837000674 trimer interface [polypeptide binding]; other site 683837000675 active site 683837000676 substrate binding site [chemical binding]; other site 683837000677 CoA binding site [chemical binding]; other site 683837000678 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 683837000679 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 683837000680 active site 683837000681 HIGH motif; other site 683837000682 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 683837000683 KMSKS motif; other site 683837000684 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 683837000685 tRNA binding surface [nucleotide binding]; other site 683837000686 anticodon binding site; other site 683837000687 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 683837000688 active site 683837000689 metal binding site [ion binding]; metal-binding site 683837000690 dimerization interface [polypeptide binding]; other site 683837000691 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 683837000692 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 683837000693 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 683837000694 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 683837000695 RNA polymerase factor sigma-70; Validated; Region: PRK08295 683837000696 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 683837000697 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 683837000698 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 683837000699 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 683837000700 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 683837000701 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 683837000702 putative homodimer interface [polypeptide binding]; other site 683837000703 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 683837000704 heterodimer interface [polypeptide binding]; other site 683837000705 homodimer interface [polypeptide binding]; other site 683837000706 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 683837000707 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 683837000708 23S rRNA interface [nucleotide binding]; other site 683837000709 L7/L12 interface [polypeptide binding]; other site 683837000710 putative thiostrepton binding site; other site 683837000711 L25 interface [polypeptide binding]; other site 683837000712 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 683837000713 mRNA/rRNA interface [nucleotide binding]; other site 683837000714 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 683837000715 23S rRNA interface [nucleotide binding]; other site 683837000716 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 683837000717 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 683837000718 core dimer interface [polypeptide binding]; other site 683837000719 peripheral dimer interface [polypeptide binding]; other site 683837000720 L10 interface [polypeptide binding]; other site 683837000721 L11 interface [polypeptide binding]; other site 683837000722 putative EF-Tu interaction site [polypeptide binding]; other site 683837000723 putative EF-G interaction site [polypeptide binding]; other site 683837000724 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 683837000725 Penicillinase repressor; Region: Pencillinase_R; pfam03965 683837000726 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 683837000727 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 683837000728 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 683837000729 Methyltransferase domain; Region: Methyltransf_31; pfam13847 683837000730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837000731 S-adenosylmethionine binding site [chemical binding]; other site 683837000732 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 683837000733 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 683837000734 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 683837000735 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 683837000736 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 683837000737 RPB10 interaction site [polypeptide binding]; other site 683837000738 RPB1 interaction site [polypeptide binding]; other site 683837000739 RPB11 interaction site [polypeptide binding]; other site 683837000740 RPB3 interaction site [polypeptide binding]; other site 683837000741 RPB12 interaction site [polypeptide binding]; other site 683837000742 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 683837000743 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 683837000744 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 683837000745 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 683837000746 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 683837000747 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 683837000748 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 683837000749 G-loop; other site 683837000750 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 683837000751 DNA binding site [nucleotide binding] 683837000752 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 683837000753 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 683837000754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837000755 active site 683837000756 motif I; other site 683837000757 motif II; other site 683837000758 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 683837000759 beta-galactosidase; Region: BGL; TIGR03356 683837000760 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 683837000761 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 683837000762 metal binding site [ion binding]; metal-binding site 683837000763 dimer interface [polypeptide binding]; other site 683837000764 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 683837000765 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 683837000766 putative Zn2+ binding site [ion binding]; other site 683837000767 putative DNA binding site [nucleotide binding]; other site 683837000768 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 683837000769 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 683837000770 Zn binding site [ion binding]; other site 683837000771 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 683837000772 Zn binding site [ion binding]; other site 683837000773 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 683837000774 catalytic core [active] 683837000775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 683837000776 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 683837000777 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 683837000778 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 683837000779 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 683837000780 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837000781 Substrate binding site [chemical binding]; other site 683837000782 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837000783 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837000784 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837000785 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 683837000786 beta-galactosidase; Region: BGL; TIGR03356 683837000787 sugar phosphate phosphatase; Provisional; Region: PRK10513 683837000788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837000789 active site 683837000790 motif I; other site 683837000791 motif II; other site 683837000792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837000793 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 683837000794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 683837000795 Coenzyme A binding pocket [chemical binding]; other site 683837000798 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 683837000799 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 683837000800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837000801 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 683837000802 active site 683837000803 motif I; other site 683837000804 motif II; other site 683837000805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837000806 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 683837000807 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 683837000808 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 683837000809 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 683837000810 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 683837000811 Walker A/P-loop; other site 683837000812 ATP binding site [chemical binding]; other site 683837000813 Q-loop/lid; other site 683837000814 ABC transporter signature motif; other site 683837000815 Walker B; other site 683837000816 D-loop; other site 683837000817 H-loop/switch region; other site 683837000818 TOBE domain; Region: TOBE; pfam03459 683837000819 ATP cone domain; Region: ATP-cone; pfam03477 683837000820 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 683837000821 Class III ribonucleotide reductase; Region: RNR_III; cd01675 683837000822 effector binding site; other site 683837000823 active site 683837000824 Zn binding site [ion binding]; other site 683837000825 glycine loop; other site 683837000826 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 683837000827 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 683837000828 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 683837000829 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 683837000830 ligand binding site [chemical binding]; other site 683837000831 flexible hinge region; other site 683837000832 Predicted amidohydrolase [General function prediction only]; Region: COG0388 683837000833 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 683837000834 putative active site [active] 683837000835 catalytic triad [active] 683837000836 putative dimer interface [polypeptide binding]; other site 683837000837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837000838 dimer interface [polypeptide binding]; other site 683837000839 conserved gate region; other site 683837000840 ABC-ATPase subunit interface; other site 683837000841 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 683837000842 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 683837000843 Walker A/P-loop; other site 683837000844 ATP binding site [chemical binding]; other site 683837000845 Q-loop/lid; other site 683837000846 ABC transporter signature motif; other site 683837000847 Walker B; other site 683837000848 D-loop; other site 683837000849 H-loop/switch region; other site 683837000850 NIL domain; Region: NIL; pfam09383 683837000851 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 683837000852 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 683837000853 transaminase; Reviewed; Region: PRK08068 683837000854 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 683837000855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837000856 homodimer interface [polypeptide binding]; other site 683837000857 catalytic residue [active] 683837000858 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 683837000859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837000860 active site 683837000861 phosphorylation site [posttranslational modification] 683837000862 intermolecular recognition site; other site 683837000863 dimerization interface [polypeptide binding]; other site 683837000864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 683837000865 DNA binding site [nucleotide binding] 683837000866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 683837000867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 683837000868 dimerization interface [polypeptide binding]; other site 683837000869 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 683837000870 putative active site [active] 683837000871 heme pocket [chemical binding]; other site 683837000872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 683837000873 dimer interface [polypeptide binding]; other site 683837000874 phosphorylation site [posttranslational modification] 683837000875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837000876 ATP binding site [chemical binding]; other site 683837000877 Mg2+ binding site [ion binding]; other site 683837000878 G-X-G motif; other site 683837000879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 683837000880 YycH protein; Region: YycH; pfam07435 683837000881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 683837000882 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 683837000883 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 683837000884 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 683837000885 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 683837000886 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 683837000887 protein binding site [polypeptide binding]; other site 683837000888 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 683837000889 HsdM N-terminal domain; Region: HsdM_N; pfam12161 683837000890 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 683837000891 Methyltransferase domain; Region: Methyltransf_26; pfam13659 683837000892 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 683837000893 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 683837000894 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 683837000895 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 683837000896 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 683837000897 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 683837000898 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 683837000899 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 683837000900 ATP binding site [chemical binding]; other site 683837000901 putative Mg++ binding site [ion binding]; other site 683837000902 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 683837000903 Mrr N-terminal domain; Region: Mrr_N; pfam14338 683837000904 Restriction endonuclease; Region: Mrr_cat; pfam04471 683837000905 Part of AAA domain; Region: AAA_19; pfam13245 683837000906 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 683837000907 NapD protein; Region: NapD; cl01163 683837000908 AAA domain; Region: AAA_30; pfam13604 683837000909 AAA domain; Region: AAA_12; pfam13087 683837000910 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 683837000911 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 683837000912 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 683837000913 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 683837000914 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 683837000915 catalytic residue [active] 683837000916 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 683837000917 beta-galactosidase; Region: BGL; TIGR03356 683837000918 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 683837000919 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 683837000920 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 683837000921 TPP-binding site [chemical binding]; other site 683837000922 dimer interface [polypeptide binding]; other site 683837000923 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 683837000924 PYR/PP interface [polypeptide binding]; other site 683837000925 dimer interface [polypeptide binding]; other site 683837000926 TPP binding site [chemical binding]; other site 683837000927 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 683837000928 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 683837000929 active site 683837000930 intersubunit interactions; other site 683837000931 catalytic residue [active] 683837000932 short chain dehydrogenase; Provisional; Region: PRK06841 683837000933 classical (c) SDRs; Region: SDR_c; cd05233 683837000934 NAD(P) binding site [chemical binding]; other site 683837000935 active site 683837000936 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 683837000937 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 683837000938 substrate binding site [chemical binding]; other site 683837000939 dimer interface [polypeptide binding]; other site 683837000940 catalytic triad [active] 683837000941 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 683837000942 DAK2 domain; Region: Dak2; cl03685 683837000943 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 683837000944 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 683837000945 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 683837000946 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 683837000947 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 683837000948 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 683837000949 putative DNA binding site [nucleotide binding]; other site 683837000950 putative Zn2+ binding site [ion binding]; other site 683837000951 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 683837000952 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 683837000953 transcriptional antiterminator BglG; Provisional; Region: PRK09772 683837000954 CAT RNA binding domain; Region: CAT_RBD; smart01061 683837000955 PRD domain; Region: PRD; pfam00874 683837000956 PRD domain; Region: PRD; pfam00874 683837000957 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 683837000958 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 683837000959 active site turn [active] 683837000960 phosphorylation site [posttranslational modification] 683837000961 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 683837000962 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1; Region: PTS_EIIA_1; pfam00358 683837000963 HPr interaction site; other site 683837000964 glycerol kinase (GK) interaction site [polypeptide binding]; other site 683837000965 active site 683837000966 phosphorylation site [posttranslational modification] 683837000967 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 683837000968 beta-galactosidase; Region: BGL; TIGR03356 683837000969 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837000970 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837000971 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 683837000972 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 683837000973 nucleotide binding site [chemical binding]; other site 683837000974 putative NEF/HSP70 interaction site [polypeptide binding]; other site 683837000975 SBD interface [polypeptide binding]; other site 683837000976 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 683837000977 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 683837000978 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 683837000979 acyl-activating enzyme (AAE) consensus motif; other site 683837000980 acyl-activating enzyme (AAE) consensus motif; other site 683837000981 active site 683837000982 AMP binding site [chemical binding]; other site 683837000983 CoA binding site [chemical binding]; other site 683837000984 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 683837000985 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 683837000986 L-aspartate oxidase; Provisional; Region: PRK06175 683837000987 putative oxidoreductase; Provisional; Region: PRK10206 683837000988 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 683837000989 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 683837000990 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 683837000991 active site 683837000992 phosphorylation site [posttranslational modification] 683837000993 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 683837000994 active site 683837000995 P-loop; other site 683837000996 phosphorylation site [posttranslational modification] 683837000997 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 683837000998 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 683837000999 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 683837001000 intersubunit interface [polypeptide binding]; other site 683837001001 active site 683837001002 zinc binding site [ion binding]; other site 683837001003 Na+ binding site [ion binding]; other site 683837001004 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 683837001005 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 683837001006 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 683837001007 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 683837001008 nudix motif; other site 683837001009 hypothetical protein; Provisional; Region: PRK12378 683837001010 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 683837001011 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 683837001012 PhnA protein; Region: PhnA; pfam03831 683837001013 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 683837001014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837001015 DNA-binding site [nucleotide binding]; DNA binding site 683837001016 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 683837001017 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 683837001018 beta-galactosidase; Region: BGL; TIGR03356 683837001019 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 683837001020 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 683837001021 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 683837001022 active site 683837001023 P-loop; other site 683837001024 phosphorylation site [posttranslational modification] 683837001025 Predicted transcriptional regulator [Transcription]; Region: COG2378 683837001026 HTH domain; Region: HTH_11; pfam08279 683837001027 WYL domain; Region: WYL; pfam13280 683837001028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837001029 non-specific DNA binding site [nucleotide binding]; other site 683837001030 salt bridge; other site 683837001031 sequence-specific DNA binding site [nucleotide binding]; other site 683837001032 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 683837001033 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 683837001034 tetrameric interface [polypeptide binding]; other site 683837001035 NAD binding site [chemical binding]; other site 683837001036 catalytic residues [active] 683837001037 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 683837001038 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 683837001039 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 683837001040 substrate binding site [chemical binding]; other site 683837001041 ATP binding site [chemical binding]; other site 683837001042 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 683837001043 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 683837001044 PYR/PP interface [polypeptide binding]; other site 683837001045 dimer interface [polypeptide binding]; other site 683837001046 TPP binding site [chemical binding]; other site 683837001047 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 683837001048 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 683837001049 TPP-binding site; other site 683837001050 Uncharacterized conserved protein [Function unknown]; Region: COG5646 683837001051 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 683837001052 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 683837001053 ligand binding site [chemical binding]; other site 683837001054 active site 683837001055 UGI interface [polypeptide binding]; other site 683837001056 catalytic site [active] 683837001057 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 683837001058 hypothetical protein; Provisional; Region: PRK13665 683837001059 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 683837001060 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 683837001061 NodB motif; other site 683837001062 active site 683837001063 catalytic site [active] 683837001064 Zn binding site [ion binding]; other site 683837001065 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 683837001066 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 683837001067 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 683837001068 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 683837001069 DNA binding residues [nucleotide binding] 683837001070 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 683837001071 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 683837001072 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 683837001073 DXD motif; other site 683837001074 Bacterial SH3 domain; Region: SH3_3; cl17532 683837001075 NlpC/P60 family; Region: NLPC_P60; pfam00877 683837001076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 683837001077 Coenzyme A binding pocket [chemical binding]; other site 683837001078 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 683837001079 pyrroline-5-carboxylate reductase; Region: PLN02688 683837001080 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 683837001081 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 683837001082 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 683837001083 Transcriptional regulators [Transcription]; Region: GntR; COG1802 683837001084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837001085 DNA-binding site [nucleotide binding]; DNA binding site 683837001086 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 683837001087 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 683837001088 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 683837001089 Walker A/P-loop; other site 683837001090 ATP binding site [chemical binding]; other site 683837001091 Q-loop/lid; other site 683837001092 ABC transporter signature motif; other site 683837001093 Walker B; other site 683837001094 D-loop; other site 683837001095 H-loop/switch region; other site 683837001096 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 683837001097 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 683837001098 FtsX-like permease family; Region: FtsX; pfam02687 683837001099 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 683837001100 putative hydrophobic ligand binding site [chemical binding]; other site 683837001101 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 683837001102 active site 683837001103 phosphorylation site [posttranslational modification] 683837001104 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 683837001105 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 683837001106 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 683837001107 putative metal binding site [ion binding]; other site 683837001108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 683837001109 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 683837001110 trimer interface [polypeptide binding]; other site 683837001111 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001112 LRR adjacent; Region: LRR_adjacent; pfam08191 683837001113 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 683837001114 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 683837001115 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 683837001116 phosphoenolpyruvate synthase; Validated; Region: PRK06241 683837001117 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 683837001118 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 683837001119 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 683837001120 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 683837001121 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 683837001122 NodB motif; other site 683837001123 active site 683837001124 catalytic site [active] 683837001125 metal binding site [ion binding]; metal-binding site 683837001126 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 683837001127 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 683837001128 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 683837001129 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 683837001130 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 683837001131 Transcriptional regulator [Transcription]; Region: LytR; COG1316 683837001132 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 683837001133 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 683837001134 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 683837001135 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 683837001136 Protein of unknown function DUF58; Region: DUF58; pfam01882 683837001137 MoxR-like ATPases [General function prediction only]; Region: COG0714 683837001138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837001139 Walker A motif; other site 683837001140 ATP binding site [chemical binding]; other site 683837001141 Walker B motif; other site 683837001142 arginine finger; other site 683837001143 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 683837001144 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 683837001145 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 683837001146 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 683837001147 Na binding site [ion binding]; other site 683837001148 Uncharacterized conserved protein [Function unknown]; Region: COG3535 683837001149 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 683837001150 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 683837001151 nucleotide binding site [chemical binding]; other site 683837001152 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 683837001153 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 683837001154 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 683837001155 Zn2+ binding site [ion binding]; other site 683837001156 Mg2+ binding site [ion binding]; other site 683837001157 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 683837001158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 683837001159 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 683837001160 Leucine rich repeat; Region: LRR_8; pfam13855 683837001161 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 683837001162 Substrate binding site [chemical binding]; other site 683837001163 Leucine rich repeat; Region: LRR_8; pfam13855 683837001164 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 683837001165 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 683837001166 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 683837001167 FeS/SAM binding site; other site 683837001168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 683837001169 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 683837001170 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 683837001171 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001172 Leucine-rich repeats; other site 683837001173 Substrate binding site [chemical binding]; other site 683837001174 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001175 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001176 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 683837001177 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001178 Leucine-rich repeats; other site 683837001179 Leucine rich repeat; Region: LRR_8; pfam13855 683837001180 Leucine rich repeat; Region: LRR_8; pfam13855 683837001181 Substrate binding site [chemical binding]; other site 683837001182 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001183 Leucine rich repeat; Region: LRR_8; pfam13855 683837001184 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 683837001185 Leucine-rich repeats; other site 683837001186 Leucine rich repeat; Region: LRR_8; pfam13855 683837001187 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001188 LRR adjacent; Region: LRR_adjacent; pfam08191 683837001189 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837001190 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837001191 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837001192 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 683837001193 putative FMN binding site [chemical binding]; other site 683837001194 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 683837001195 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 683837001196 putative ADP-binding pocket [chemical binding]; other site 683837001197 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 683837001198 oxidoreductase; Provisional; Region: PRK07985 683837001199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 683837001200 NAD(P) binding site [chemical binding]; other site 683837001201 active site 683837001202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 683837001203 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 683837001204 nudix motif; other site 683837001205 Transcriptional regulator [Transcription]; Region: LysR; COG0583 683837001206 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 683837001207 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 683837001208 putative dimerization interface [polypeptide binding]; other site 683837001209 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 683837001210 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 683837001211 active site 683837001212 FMN binding site [chemical binding]; other site 683837001213 substrate binding site [chemical binding]; other site 683837001214 putative catalytic residue [active] 683837001215 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 683837001216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 683837001217 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 683837001218 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 683837001219 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 683837001220 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 683837001221 shikimate binding site; other site 683837001222 NAD(P) binding site [chemical binding]; other site 683837001223 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 683837001224 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 683837001225 active site 683837001226 catalytic residue [active] 683837001227 dimer interface [polypeptide binding]; other site 683837001228 Transcriptional regulator [Transcription]; Region: LysR; COG0583 683837001229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 683837001230 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 683837001231 dimerization interface [polypeptide binding]; other site 683837001232 Predicted acyl esterases [General function prediction only]; Region: COG2936 683837001233 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 683837001234 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 683837001235 active site 683837001236 catalytic triad [active] 683837001237 oxyanion hole [active] 683837001238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 683837001239 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 683837001240 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 683837001241 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 683837001242 active site 683837001243 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 683837001244 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 683837001245 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 683837001246 catalytic triad [active] 683837001247 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 683837001248 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 683837001249 MarR family; Region: MarR_2; pfam12802 683837001250 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001251 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 683837001252 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 683837001253 Ligand Binding Site [chemical binding]; other site 683837001254 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 683837001255 catalytic core [active] 683837001256 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 683837001257 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 683837001258 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754 683837001259 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 683837001260 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 683837001261 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 683837001262 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 683837001263 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 683837001264 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 683837001265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 683837001266 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 683837001267 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 683837001268 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 683837001269 Predicted membrane protein [Function unknown]; Region: COG3759 683837001270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837001271 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837001272 putative substrate translocation pore; other site 683837001273 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 683837001274 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 683837001275 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 683837001276 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 683837001277 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 683837001278 NAD binding site [chemical binding]; other site 683837001279 sugar binding site [chemical binding]; other site 683837001280 divalent metal binding site [ion binding]; other site 683837001281 tetramer (dimer of dimers) interface [polypeptide binding]; other site 683837001282 dimer interface [polypeptide binding]; other site 683837001283 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 683837001284 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 683837001285 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 683837001286 putative active site [active] 683837001287 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 683837001288 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 683837001289 Sulfate transporter family; Region: Sulfate_transp; pfam00916 683837001290 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 683837001291 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 683837001292 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 683837001293 DNA binding residues [nucleotide binding] 683837001294 dimer interface [polypeptide binding]; other site 683837001295 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 683837001296 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 683837001297 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 683837001298 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 683837001299 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 683837001300 DXD motif; other site 683837001301 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 683837001302 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 683837001303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 683837001304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837001305 S-adenosylmethionine binding site [chemical binding]; other site 683837001306 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 683837001307 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 683837001308 Transcriptional regulators [Transcription]; Region: PurR; COG1609 683837001309 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 683837001310 DNA binding site [nucleotide binding] 683837001311 domain linker motif; other site 683837001312 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 683837001313 putative dimerization interface [polypeptide binding]; other site 683837001314 putative ligand binding site [chemical binding]; other site 683837001315 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 683837001316 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 683837001317 NAD binding site [chemical binding]; other site 683837001318 sugar binding site [chemical binding]; other site 683837001319 divalent metal binding site [ion binding]; other site 683837001320 tetramer (dimer of dimers) interface [polypeptide binding]; other site 683837001321 dimer interface [polypeptide binding]; other site 683837001322 allantoate amidohydrolase; Reviewed; Region: PRK09290 683837001323 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 683837001324 active site 683837001325 metal binding site [ion binding]; metal-binding site 683837001326 dimer interface [polypeptide binding]; other site 683837001327 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 683837001328 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 683837001329 metal binding site [ion binding]; metal-binding site 683837001330 putative dimer interface [polypeptide binding]; other site 683837001331 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 683837001332 Beta-lactamase; Region: Beta-lactamase; pfam00144 683837001333 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 683837001334 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 683837001335 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 683837001336 intersubunit interface [polypeptide binding]; other site 683837001337 FOG: CBS domain [General function prediction only]; Region: COG0517 683837001338 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 683837001339 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 683837001340 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 683837001341 dimer interface [polypeptide binding]; other site 683837001342 active site 683837001343 metal binding site [ion binding]; metal-binding site 683837001344 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 683837001345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837001346 putative substrate translocation pore; other site 683837001347 POT family; Region: PTR2; pfam00854 683837001348 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 683837001349 catalytic core [active] 683837001350 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 683837001351 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 683837001352 catalytic core [active] 683837001353 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 683837001354 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 683837001355 LXG domain of WXG superfamily; Region: LXG; pfam04740 683837001356 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 683837001357 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 683837001358 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 683837001359 Cl binding site [ion binding]; other site 683837001360 oligomer interface [polypeptide binding]; other site 683837001361 glutamate dehydrogenase; Provisional; Region: PRK09414 683837001362 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 683837001363 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 683837001364 NAD(P) binding site [chemical binding]; other site 683837001365 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 683837001366 metal binding site [ion binding]; metal-binding site 683837001367 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 683837001368 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 683837001369 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 683837001370 substrate binding site [chemical binding]; other site 683837001371 glutamase interaction surface [polypeptide binding]; other site 683837001372 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 683837001373 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 683837001374 catalytic residues [active] 683837001375 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 683837001376 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 683837001377 putative active site [active] 683837001378 oxyanion strand; other site 683837001379 catalytic triad [active] 683837001380 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 683837001381 4-fold oligomerization interface [polypeptide binding]; other site 683837001382 putative active site pocket [active] 683837001383 metal binding residues [ion binding]; metal-binding site 683837001384 3-fold/trimer interface [polypeptide binding]; other site 683837001385 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 683837001386 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 683837001387 NAD binding site [chemical binding]; other site 683837001388 dimerization interface [polypeptide binding]; other site 683837001389 product binding site; other site 683837001390 substrate binding site [chemical binding]; other site 683837001391 zinc binding site [ion binding]; other site 683837001392 catalytic residues [active] 683837001393 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 683837001394 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 683837001395 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 683837001396 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 683837001397 dimer interface [polypeptide binding]; other site 683837001398 motif 1; other site 683837001399 active site 683837001400 motif 2; other site 683837001401 motif 3; other site 683837001402 histidinol-phosphatase; Reviewed; Region: PRK08123 683837001403 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 683837001404 active site 683837001405 dimer interface [polypeptide binding]; other site 683837001406 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 683837001407 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 683837001408 DNA binding site [nucleotide binding] 683837001409 active site 683837001410 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 683837001411 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 683837001412 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 683837001413 beta-galactosidase; Region: BGL; TIGR03356 683837001414 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 683837001415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837001416 DNA-binding site [nucleotide binding]; DNA binding site 683837001417 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 683837001418 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 683837001419 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 683837001420 xylose isomerase; Provisional; Region: PRK05474 683837001421 xylose isomerase; Region: xylose_isom_A; TIGR02630 683837001422 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 683837001423 N- and C-terminal domain interface [polypeptide binding]; other site 683837001424 D-xylulose kinase; Region: XylB; TIGR01312 683837001425 active site 683837001426 MgATP binding site [chemical binding]; other site 683837001427 catalytic site [active] 683837001428 metal binding site [ion binding]; metal-binding site 683837001429 xylulose binding site [chemical binding]; other site 683837001430 homodimer interface [polypeptide binding]; other site 683837001431 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 683837001432 Uncharacterized conserved protein [Function unknown]; Region: COG2966 683837001433 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 683837001434 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 683837001435 Predicted esterase [General function prediction only]; Region: COG0400 683837001436 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 683837001437 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 683837001438 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 683837001439 putative RNA binding site [nucleotide binding]; other site 683837001440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837001441 S-adenosylmethionine binding site [chemical binding]; other site 683837001442 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 683837001443 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 683837001444 Bacterial SH3 domain; Region: SH3_3; pfam08239 683837001445 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 683837001446 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 683837001447 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 683837001448 NlpC/P60 family; Region: NLPC_P60; pfam00877 683837001449 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 683837001450 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 683837001451 ATP binding site [chemical binding]; other site 683837001452 putative Mg++ binding site [ion binding]; other site 683837001453 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 683837001454 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 683837001455 nucleotide binding region [chemical binding]; other site 683837001456 ATP-binding site [chemical binding]; other site 683837001457 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 683837001458 Domain of unknown function DUF20; Region: UPF0118; pfam01594 683837001459 WxL domain surface cell wall-binding; Region: WxL; pfam13731 683837001460 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 683837001461 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 683837001462 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 683837001463 DNA photolyase; Region: DNA_photolyase; pfam00875 683837001464 Predicted membrane protein [Function unknown]; Region: COG4852 683837001465 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 683837001466 DAK2 domain; Region: Dak2; pfam02734 683837001467 EDD domain protein, DegV family; Region: DegV; TIGR00762 683837001468 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 683837001469 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 683837001470 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 683837001471 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 683837001472 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 683837001473 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 683837001474 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 683837001475 homodimer interface [polypeptide binding]; other site 683837001476 substrate-cofactor binding pocket; other site 683837001477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837001478 catalytic residue [active] 683837001479 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 683837001480 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 683837001481 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 683837001482 ligand binding site [chemical binding]; other site 683837001483 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 683837001484 BioY family; Region: BioY; pfam02632 683837001485 Predicted transcriptional regulators [Transcription]; Region: COG1695 683837001486 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 683837001487 Predicted membrane protein [Function unknown]; Region: COG4709 683837001488 Uncharacterized conserved protein [Function unknown]; Region: COG3595 683837001489 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 683837001490 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 683837001491 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 683837001492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 683837001493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 683837001494 Coenzyme A binding pocket [chemical binding]; other site 683837001495 Tic20-like protein; Region: Tic20; pfam09685 683837001496 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 683837001497 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 683837001498 Transcriptional regulators [Transcription]; Region: MarR; COG1846 683837001499 MarR family; Region: MarR_2; pfam12802 683837001500 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 683837001501 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 683837001502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837001503 Walker A/P-loop; other site 683837001504 ATP binding site [chemical binding]; other site 683837001505 Q-loop/lid; other site 683837001506 ABC transporter signature motif; other site 683837001507 Walker B; other site 683837001508 D-loop; other site 683837001509 H-loop/switch region; other site 683837001510 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 683837001511 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 683837001512 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 683837001513 Walker A/P-loop; other site 683837001514 ATP binding site [chemical binding]; other site 683837001515 Q-loop/lid; other site 683837001516 ABC transporter signature motif; other site 683837001517 Walker B; other site 683837001518 D-loop; other site 683837001519 H-loop/switch region; other site 683837001520 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 683837001521 active site residue [active] 683837001522 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001523 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 683837001524 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 683837001525 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 683837001526 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 683837001527 putative DNA binding site [nucleotide binding]; other site 683837001528 putative Zn2+ binding site [ion binding]; other site 683837001529 MarR family; Region: MarR_2; cl17246 683837001530 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 683837001531 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 683837001532 putative NAD(P) binding site [chemical binding]; other site 683837001533 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 683837001534 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 683837001535 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 683837001536 putative active site [active] 683837001537 catalytic site [active] 683837001538 putative metal binding site [ion binding]; other site 683837001539 Catalytic domain of Protein Kinases; Region: PKc; cd00180 683837001540 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 683837001541 active site 683837001542 ATP binding site [chemical binding]; other site 683837001543 substrate binding site [chemical binding]; other site 683837001544 activation loop (A-loop); other site 683837001545 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 683837001546 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 683837001547 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 683837001548 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 683837001549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 683837001550 Coenzyme A binding pocket [chemical binding]; other site 683837001551 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 683837001552 active site 683837001553 catalytic triad [active] 683837001554 oxyanion hole [active] 683837001555 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 683837001556 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 683837001557 ATP synthase subunit C; Region: ATP-synt_C; cl00466 683837001558 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 683837001559 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 683837001560 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 683837001561 Walker A motif; other site 683837001562 ATP binding site [chemical binding]; other site 683837001563 Walker B motif; other site 683837001564 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 683837001565 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 683837001566 core domain interface [polypeptide binding]; other site 683837001567 delta subunit interface [polypeptide binding]; other site 683837001568 epsilon subunit interface [polypeptide binding]; other site 683837001569 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 683837001570 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 683837001571 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 683837001572 alpha subunit interaction interface [polypeptide binding]; other site 683837001573 Walker A motif; other site 683837001574 ATP binding site [chemical binding]; other site 683837001575 Walker B motif; other site 683837001576 inhibitor binding site; inhibition site 683837001577 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 683837001578 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 683837001579 gamma subunit interface [polypeptide binding]; other site 683837001580 epsilon subunit interface [polypeptide binding]; other site 683837001581 LBP interface [polypeptide binding]; other site 683837001582 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 683837001583 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 683837001584 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 683837001585 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 683837001586 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 683837001587 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 683837001588 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 683837001589 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 683837001590 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 683837001591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837001592 motif II; other site 683837001593 Rrf2 family protein; Region: rrf2_super; TIGR00738 683837001594 Transcriptional regulator; Region: Rrf2; pfam02082 683837001595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837001596 S-adenosylmethionine binding site [chemical binding]; other site 683837001597 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 683837001598 LXG domain of WXG superfamily; Region: LXG; pfam04740 683837001599 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 683837001600 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 683837001601 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 683837001602 active site 683837001603 catalytic tetrad [active] 683837001604 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 683837001605 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 683837001606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837001607 motif II; other site 683837001608 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 683837001609 catalytic residue [active] 683837001610 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 683837001611 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 683837001612 Sulfatase; Region: Sulfatase; pfam00884 683837001613 amino acid transporter; Region: 2A0306; TIGR00909 683837001614 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 683837001615 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 683837001616 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 683837001617 putative metal binding site [ion binding]; other site 683837001618 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 683837001619 active site 683837001620 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 683837001621 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 683837001622 Cl binding site [ion binding]; other site 683837001623 oligomer interface [polypeptide binding]; other site 683837001624 Transcriptional regulators [Transcription]; Region: GntR; COG1802 683837001625 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837001626 DNA-binding site [nucleotide binding]; DNA binding site 683837001627 Predicted membrane protein [Function unknown]; Region: COG1511 683837001628 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 683837001629 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 683837001630 linker region; other site 683837001631 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 683837001632 Transcriptional regulators [Transcription]; Region: FadR; COG2186 683837001633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837001634 DNA-binding site [nucleotide binding]; DNA binding site 683837001635 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 683837001636 Protein of unknown function (DUF975); Region: DUF975; cl10504 683837001637 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 683837001638 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 683837001639 active site 683837001640 metal binding site [ion binding]; metal-binding site 683837001641 Predicted membrane protein [Function unknown]; Region: COG2322 683837001642 Flavin Reductases; Region: FlaRed; cl00801 683837001643 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 683837001644 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 683837001645 conserved cys residue [active] 683837001646 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 683837001647 dimer interface [polypeptide binding]; other site 683837001648 substrate binding site [chemical binding]; other site 683837001649 ATP binding site [chemical binding]; other site 683837001650 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 683837001651 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837001652 active site 683837001653 motif I; other site 683837001654 motif II; other site 683837001655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837001656 maltose O-acetyltransferase; Provisional; Region: PRK10092 683837001657 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 683837001658 active site 683837001659 substrate binding site [chemical binding]; other site 683837001660 trimer interface [polypeptide binding]; other site 683837001661 CoA binding site [chemical binding]; other site 683837001662 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 683837001663 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 683837001664 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 683837001665 Walker A/P-loop; other site 683837001666 ATP binding site [chemical binding]; other site 683837001667 Q-loop/lid; other site 683837001668 ABC transporter signature motif; other site 683837001669 Walker B; other site 683837001670 D-loop; other site 683837001671 H-loop/switch region; other site 683837001672 inner membrane transport permease; Provisional; Region: PRK15066 683837001673 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 683837001674 Predicted membrane protein [Function unknown]; Region: COG3152 683837001675 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 683837001676 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 683837001677 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 683837001678 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 683837001679 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 683837001680 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 683837001681 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 683837001682 FHIPEP family; Region: FHIPEP; pfam00771 683837001683 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 683837001684 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 683837001685 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 683837001686 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 683837001687 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 683837001688 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 683837001689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837001690 S-adenosylmethionine binding site [chemical binding]; other site 683837001691 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 683837001692 flagellar motor protein MotA; Validated; Region: PRK08124 683837001693 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 683837001694 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 683837001695 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 683837001696 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 683837001697 ligand binding site [chemical binding]; other site 683837001698 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 683837001699 putative metal binding site; other site 683837001700 TPR repeat; Region: TPR_11; pfam13414 683837001701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 683837001702 binding surface 683837001703 TPR motif; other site 683837001704 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 683837001705 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 683837001706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837001707 active site 683837001708 phosphorylation site [posttranslational modification] 683837001709 intermolecular recognition site; other site 683837001710 dimerization interface [polypeptide binding]; other site 683837001711 flagellin; Provisional; Region: PRK12805 683837001712 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 683837001713 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 683837001714 Response regulator receiver domain; Region: Response_reg; pfam00072 683837001715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837001716 active site 683837001717 phosphorylation site [posttranslational modification] 683837001718 intermolecular recognition site; other site 683837001719 dimerization interface [polypeptide binding]; other site 683837001720 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 683837001721 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 683837001722 putative binding surface; other site 683837001723 active site 683837001724 P2 response regulator binding domain; Region: P2; pfam07194 683837001725 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 683837001726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837001727 ATP binding site [chemical binding]; other site 683837001728 Mg2+ binding site [ion binding]; other site 683837001729 G-X-G motif; other site 683837001730 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 683837001731 flagellar motor switch protein; Validated; Region: PRK06788 683837001732 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 683837001733 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 683837001734 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 683837001735 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 683837001736 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 683837001737 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 683837001738 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 683837001739 flagellar motor switch protein; Validated; Region: PRK06789 683837001740 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 683837001741 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 683837001742 flagellar motor switch protein; Reviewed; Region: PRK06782 683837001743 CheC-like family; Region: CheC; pfam04509 683837001744 CheC-like family; Region: CheC; pfam04509 683837001745 Chemotaxis phosphatase CheX; Region: CheX; cl15816 683837001746 CheC-like family; Region: CheC; pfam04509 683837001747 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 683837001748 Protein of unknown function (DUF327); Region: DUF327; pfam03885 683837001749 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 683837001750 glycoprotein BALF4; Provisional; Region: PHA03231 683837001751 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 683837001752 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 683837001753 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 683837001754 flagellar capping protein; Validated; Region: fliD; PRK06798 683837001755 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 683837001756 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 683837001757 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 683837001758 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 683837001759 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 683837001760 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 683837001761 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 683837001762 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 683837001763 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 683837001764 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 683837001765 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 683837001766 FliG C-terminal domain; Region: FliG_C; pfam01706 683837001767 flagellar assembly protein H; Validated; Region: fliH; PRK06800 683837001768 Flagellar assembly protein FliH; Region: FliH; pfam02108 683837001769 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 683837001770 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 683837001771 Walker A motif; other site 683837001772 ATP binding site [chemical binding]; other site 683837001773 Walker B motif; other site 683837001774 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 683837001775 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 683837001776 N-acetyl-D-glucosamine binding site [chemical binding]; other site 683837001777 catalytic residue [active] 683837001778 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 683837001779 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 683837001780 Soluble P-type ATPase [General function prediction only]; Region: COG4087 683837001781 Predicted transcriptional regulators [Transcription]; Region: COG1695 683837001782 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 683837001783 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 683837001784 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 683837001785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837001786 Walker A/P-loop; other site 683837001787 ATP binding site [chemical binding]; other site 683837001788 Q-loop/lid; other site 683837001789 ABC transporter signature motif; other site 683837001790 Walker B; other site 683837001791 D-loop; other site 683837001792 H-loop/switch region; other site 683837001793 ABC-2 type transporter; Region: ABC2_membrane; cl17235 683837001794 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 683837001795 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001796 Leucine rich repeat; Region: LRR_8; pfam13855 683837001797 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 683837001798 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 683837001799 Leucine-rich repeats; other site 683837001800 Substrate binding site [chemical binding]; other site 683837001801 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 683837001802 LRR adjacent; Region: LRR_adjacent; pfam08191 683837001803 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 683837001804 pyruvate oxidase; Provisional; Region: PRK08611 683837001805 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 683837001806 PYR/PP interface [polypeptide binding]; other site 683837001807 dimer interface [polypeptide binding]; other site 683837001808 tetramer interface [polypeptide binding]; other site 683837001809 TPP binding site [chemical binding]; other site 683837001810 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 683837001811 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 683837001812 TPP-binding site [chemical binding]; other site 683837001813 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 683837001814 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 683837001815 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 683837001816 dimerization interface [polypeptide binding]; other site 683837001817 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 683837001818 dimer interface [polypeptide binding]; other site 683837001819 putative CheW interface [polypeptide binding]; other site 683837001820 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 683837001821 putative active site [active] 683837001822 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 683837001823 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 683837001824 glutaminase active site [active] 683837001825 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 683837001826 dimer interface [polypeptide binding]; other site 683837001827 active site 683837001828 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 683837001829 dimer interface [polypeptide binding]; other site 683837001830 active site 683837001831 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 683837001832 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 683837001833 active site 683837001834 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 683837001835 GIY-YIG motif/motif A; other site 683837001836 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001837 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001838 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001839 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 683837001840 Leucine-rich repeats; other site 683837001841 Substrate binding site [chemical binding]; other site 683837001842 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001843 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001844 LRR adjacent; Region: LRR_adjacent; pfam08191 683837001845 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 683837001846 Leucine rich repeat; Region: LRR_8; pfam13855 683837001847 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837001848 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837001849 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 683837001850 topology modulation protein; Reviewed; Region: PRK08118 683837001851 AAA domain; Region: AAA_17; pfam13207 683837001852 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 683837001853 active site 683837001854 catalytic triad [active] 683837001855 oxyanion hole [active] 683837001856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837001857 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 683837001858 Walker A/P-loop; other site 683837001859 ATP binding site [chemical binding]; other site 683837001860 Q-loop/lid; other site 683837001861 ABC transporter signature motif; other site 683837001862 Walker B; other site 683837001863 D-loop; other site 683837001864 H-loop/switch region; other site 683837001865 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 683837001866 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 683837001867 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 683837001868 Zn binding site [ion binding]; other site 683837001869 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 683837001870 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 683837001871 Zn binding site [ion binding]; other site 683837001872 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 683837001873 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 683837001874 Zn binding site [ion binding]; other site 683837001875 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 683837001876 Zn binding site [ion binding]; other site 683837001877 Predicted esterase [General function prediction only]; Region: COG0400 683837001878 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 683837001879 GTPases [General function prediction only]; Region: HflX; COG2262 683837001880 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 683837001881 HflX GTPase family; Region: HflX; cd01878 683837001882 G1 box; other site 683837001883 GTP/Mg2+ binding site [chemical binding]; other site 683837001884 Switch I region; other site 683837001885 G2 box; other site 683837001886 G3 box; other site 683837001887 Switch II region; other site 683837001888 G4 box; other site 683837001889 G5 box; other site 683837001890 phosphodiesterase YaeI; Provisional; Region: PRK11340 683837001891 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 683837001892 putative active site [active] 683837001893 putative metal binding site [ion binding]; other site 683837001894 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 683837001895 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 683837001896 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 683837001897 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 683837001898 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 683837001899 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837001900 LRR adjacent; Region: LRR_adjacent; pfam08191 683837001901 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 683837001902 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 683837001903 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 683837001904 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 683837001905 Uncharacterized conserved protein [Function unknown]; Region: COG3538 683837001906 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 683837001907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 683837001908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837001909 putative PBP binding loops; other site 683837001910 ABC-ATPase subunit interface; other site 683837001911 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 683837001912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837001913 dimer interface [polypeptide binding]; other site 683837001914 conserved gate region; other site 683837001915 putative PBP binding loops; other site 683837001916 ABC-ATPase subunit interface; other site 683837001917 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 683837001918 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 683837001919 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 683837001920 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 683837001921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837001922 DNA-binding site [nucleotide binding]; DNA binding site 683837001923 Transcriptional regulators [Transcription]; Region: PurR; COG1609 683837001924 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 683837001925 ligand binding site [chemical binding]; other site 683837001926 dimerization interface [polypeptide binding]; other site 683837001927 Transcriptional regulators [Transcription]; Region: GntR; COG1802 683837001928 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837001929 DNA-binding site [nucleotide binding]; DNA binding site 683837001930 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 683837001931 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 683837001932 putative NADP binding site [chemical binding]; other site 683837001933 putative dimer interface [polypeptide binding]; other site 683837001934 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 683837001935 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 683837001936 Pleckstrin homology-like domain; Region: PH-like; cl17171 683837001937 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 683837001938 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 683837001939 nucleotide binding site [chemical binding]; other site 683837001940 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 683837001941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837001942 non-specific DNA binding site [nucleotide binding]; other site 683837001943 salt bridge; other site 683837001944 sequence-specific DNA binding site [nucleotide binding]; other site 683837001945 Predicted membrane protein [Function unknown]; Region: COG4811 683837001946 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 683837001947 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 683837001948 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 683837001949 active site 683837001950 phosphorylation site [posttranslational modification] 683837001951 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 683837001952 active pocket/dimerization site; other site 683837001953 active site 683837001954 phosphorylation site [posttranslational modification] 683837001955 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 683837001956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837001957 Walker A motif; other site 683837001958 ATP binding site [chemical binding]; other site 683837001959 Walker B motif; other site 683837001960 arginine finger; other site 683837001961 Transcriptional antiterminator [Transcription]; Region: COG3933 683837001962 PRD domain; Region: PRD; pfam00874 683837001963 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 683837001964 active pocket/dimerization site; other site 683837001965 active site 683837001966 phosphorylation site [posttranslational modification] 683837001967 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 683837001968 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 683837001969 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 683837001970 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 683837001971 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 683837001972 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 683837001973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 683837001974 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 683837001975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 683837001976 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 683837001977 putative deacylase active site [active] 683837001978 Protein of unknown function (DUF554); Region: DUF554; pfam04474 683837001979 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 683837001980 NADH(P)-binding; Region: NAD_binding_10; pfam13460 683837001981 NAD binding site [chemical binding]; other site 683837001982 putative active site [active] 683837001983 substrate binding site [chemical binding]; other site 683837001984 Predicted permeases [General function prediction only]; Region: RarD; COG2962 683837001985 EamA-like transporter family; Region: EamA; pfam00892 683837001986 Uncharacterized conserved protein [Function unknown]; Region: COG2353 683837001987 Transcriptional regulators [Transcription]; Region: MarR; COG1846 683837001988 MarR family; Region: MarR_2; pfam12802 683837001989 lysine transporter; Provisional; Region: PRK10836 683837001990 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 683837001991 PAS domain; Region: PAS_9; pfam13426 683837001992 putative active site [active] 683837001993 heme pocket [chemical binding]; other site 683837001994 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 683837001995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 683837001996 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 683837001997 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 683837001998 synthetase active site [active] 683837001999 NTP binding site [chemical binding]; other site 683837002000 metal binding site [ion binding]; metal-binding site 683837002001 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 683837002002 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 683837002003 LRR adjacent; Region: LRR_adjacent; pfam08191 683837002004 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837002005 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 683837002006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837002007 non-specific DNA binding site [nucleotide binding]; other site 683837002008 salt bridge; other site 683837002009 sequence-specific DNA binding site [nucleotide binding]; other site 683837002010 Cupin domain; Region: Cupin_2; pfam07883 683837002011 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 683837002012 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 683837002013 Walker A/P-loop; other site 683837002014 ATP binding site [chemical binding]; other site 683837002015 Q-loop/lid; other site 683837002016 ABC transporter signature motif; other site 683837002017 Walker B; other site 683837002018 D-loop; other site 683837002019 H-loop/switch region; other site 683837002020 TOBE domain; Region: TOBE_2; pfam08402 683837002021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 683837002022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837002023 putative PBP binding loops; other site 683837002024 ABC-ATPase subunit interface; other site 683837002025 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 683837002026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837002027 dimer interface [polypeptide binding]; other site 683837002028 conserved gate region; other site 683837002029 putative PBP binding loops; other site 683837002030 ABC-ATPase subunit interface; other site 683837002031 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 683837002032 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 683837002033 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 683837002034 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 683837002035 active site 683837002036 zinc binding site [ion binding]; other site 683837002037 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 683837002038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 683837002039 Zn2+ binding site [ion binding]; other site 683837002040 Mg2+ binding site [ion binding]; other site 683837002041 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 683837002042 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 683837002043 nucleotide binding site [chemical binding]; other site 683837002044 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 683837002045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837002046 active site 683837002047 phosphorylation site [posttranslational modification] 683837002048 intermolecular recognition site; other site 683837002049 dimerization interface [polypeptide binding]; other site 683837002050 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 683837002051 DNA binding site [nucleotide binding] 683837002052 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 683837002053 dimerization interface [polypeptide binding]; other site 683837002054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 683837002055 dimer interface [polypeptide binding]; other site 683837002056 phosphorylation site [posttranslational modification] 683837002057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837002058 ATP binding site [chemical binding]; other site 683837002059 Mg2+ binding site [ion binding]; other site 683837002060 G-X-G motif; other site 683837002061 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 683837002062 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 683837002063 FtsX-like permease family; Region: FtsX; pfam02687 683837002064 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 683837002065 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 683837002066 Walker A/P-loop; other site 683837002067 ATP binding site [chemical binding]; other site 683837002068 Q-loop/lid; other site 683837002069 ABC transporter signature motif; other site 683837002070 Walker B; other site 683837002071 D-loop; other site 683837002072 H-loop/switch region; other site 683837002073 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 683837002074 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 683837002075 FMN binding site [chemical binding]; other site 683837002076 substrate binding site [chemical binding]; other site 683837002077 putative catalytic residue [active] 683837002078 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 683837002079 dimer interface [polypeptide binding]; other site 683837002080 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 683837002081 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 683837002082 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 683837002083 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 683837002084 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 683837002085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837002086 motif II; other site 683837002087 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 683837002088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 683837002089 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 683837002090 Coenzyme A binding pocket [chemical binding]; other site 683837002091 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 683837002092 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 683837002093 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 683837002094 DNA binding residues [nucleotide binding] 683837002095 putative dimer interface [polypeptide binding]; other site 683837002096 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 683837002097 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 683837002098 active site 683837002099 catalytic tetrad [active] 683837002100 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837002101 Leucine rich repeat; Region: LRR_8; pfam13855 683837002102 Leucine rich repeat; Region: LRR_8; pfam13855 683837002103 LRR adjacent; Region: LRR_adjacent; pfam08191 683837002104 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837002105 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 683837002106 Leucine-rich repeats; other site 683837002107 Substrate binding site [chemical binding]; other site 683837002108 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837002109 Leucine rich repeat; Region: LRR_8; pfam13855 683837002110 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 683837002111 Leucine-rich repeats; other site 683837002112 Substrate binding site [chemical binding]; other site 683837002113 Leucine rich repeat; Region: LRR_8; pfam13855 683837002114 Leucine rich repeat; Region: LRR_8; pfam13855 683837002115 Leucine rich repeat; Region: LRR_8; pfam13855 683837002116 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 683837002117 Leucine rich repeat; Region: LRR_8; pfam13855 683837002118 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 683837002119 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837002120 Leucine rich repeat; Region: LRR_8; pfam13855 683837002121 LRR adjacent; Region: LRR_adjacent; pfam08191 683837002122 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 683837002123 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 683837002124 homodimer interface [polypeptide binding]; other site 683837002125 catalytic residues [active] 683837002126 NAD binding site [chemical binding]; other site 683837002127 substrate binding pocket [chemical binding]; other site 683837002128 flexible flap; other site 683837002129 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 683837002130 active site 683837002131 substrate binding site [chemical binding]; other site 683837002132 trimer interface [polypeptide binding]; other site 683837002133 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 683837002134 CoA binding site [chemical binding]; other site 683837002135 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 683837002136 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 683837002137 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 683837002138 dimerization interface [polypeptide binding]; other site 683837002139 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 683837002140 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 683837002141 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 683837002142 PhoU domain; Region: PhoU; pfam01895 683837002143 PhoU domain; Region: PhoU; pfam01895 683837002144 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 683837002145 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 683837002146 dimer interface [polypeptide binding]; other site 683837002147 PYR/PP interface [polypeptide binding]; other site 683837002148 TPP binding site [chemical binding]; other site 683837002149 substrate binding site [chemical binding]; other site 683837002150 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 683837002151 Domain of unknown function; Region: EKR; smart00890 683837002152 4Fe-4S binding domain; Region: Fer4_6; pfam12837 683837002153 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 683837002154 TPP-binding site [chemical binding]; other site 683837002155 dimer interface [polypeptide binding]; other site 683837002156 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 683837002157 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 683837002158 Predicted permeases [General function prediction only]; Region: COG0679 683837002159 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 683837002160 Leucine rich repeat; Region: LRR_8; pfam13855 683837002161 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 683837002162 Leucine rich repeat; Region: LRR_8; pfam13855 683837002163 Predicted membrane protein [Function unknown]; Region: COG3223 683837002164 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 683837002165 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 683837002166 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 683837002167 Walker A/P-loop; other site 683837002168 ATP binding site [chemical binding]; other site 683837002169 Q-loop/lid; other site 683837002170 ABC transporter signature motif; other site 683837002171 Walker B; other site 683837002172 D-loop; other site 683837002173 H-loop/switch region; other site 683837002174 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 683837002175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837002176 putative substrate translocation pore; other site 683837002177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837002178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837002179 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837002180 putative substrate translocation pore; other site 683837002181 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 683837002182 MarR family; Region: MarR; pfam01047 683837002183 MarR family; Region: MarR_2; cl17246 683837002184 Transcriptional regulator [Transcription]; Region: LysR; COG0583 683837002185 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 683837002186 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 683837002187 dimerization interface [polypeptide binding]; other site 683837002188 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 683837002189 EamA-like transporter family; Region: EamA; pfam00892 683837002190 EamA-like transporter family; Region: EamA; pfam00892 683837002191 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 683837002192 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 683837002193 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 683837002194 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 683837002195 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837002196 motif II; other site 683837002197 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 683837002198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837002199 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 683837002200 active site 683837002201 motif I; other site 683837002202 motif II; other site 683837002203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 683837002204 Predicted membrane protein [Function unknown]; Region: COG3326 683837002205 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 683837002206 homotrimer interaction site [polypeptide binding]; other site 683837002207 putative active site [active] 683837002208 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 683837002209 substrate binding site [chemical binding]; other site 683837002210 zinc-binding site [ion binding]; other site 683837002211 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 683837002212 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 683837002213 GIY-YIG motif/motif A; other site 683837002214 active site 683837002215 catalytic site [active] 683837002216 putative DNA binding site [nucleotide binding]; other site 683837002217 metal binding site [ion binding]; metal-binding site 683837002218 UvrB/uvrC motif; Region: UVR; pfam02151 683837002219 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 683837002220 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 683837002221 substrate binding pocket [chemical binding]; other site 683837002222 membrane-bound complex binding site; other site 683837002223 hinge residues; other site 683837002224 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 683837002225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837002226 dimer interface [polypeptide binding]; other site 683837002227 conserved gate region; other site 683837002228 putative PBP binding loops; other site 683837002229 ABC-ATPase subunit interface; other site 683837002230 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 683837002231 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 683837002232 Walker A/P-loop; other site 683837002233 ATP binding site [chemical binding]; other site 683837002234 Q-loop/lid; other site 683837002235 ABC transporter signature motif; other site 683837002236 Walker B; other site 683837002237 D-loop; other site 683837002238 H-loop/switch region; other site 683837002239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 683837002240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 683837002241 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 683837002242 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 683837002243 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 683837002244 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 683837002245 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 683837002246 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 683837002247 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 683837002248 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 683837002249 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 683837002250 Esterase/lipase [General function prediction only]; Region: COG1647 683837002251 Transcriptional regulators [Transcription]; Region: PurR; COG1609 683837002252 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 683837002253 DNA binding site [nucleotide binding] 683837002254 domain linker motif; other site 683837002255 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 683837002256 putative dimerization interface [polypeptide binding]; other site 683837002257 putative ligand binding site [chemical binding]; other site 683837002258 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 683837002259 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 683837002260 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 683837002261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837002262 dimer interface [polypeptide binding]; other site 683837002263 conserved gate region; other site 683837002264 putative PBP binding loops; other site 683837002265 ABC-ATPase subunit interface; other site 683837002266 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 683837002267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837002268 dimer interface [polypeptide binding]; other site 683837002269 conserved gate region; other site 683837002270 ABC-ATPase subunit interface; other site 683837002271 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 683837002272 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 683837002273 Ca binding site [ion binding]; other site 683837002274 active site 683837002275 catalytic site [active] 683837002276 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 683837002277 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 683837002278 active site 683837002279 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 683837002280 active site 683837002281 substrate binding site [chemical binding]; other site 683837002282 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 683837002283 metal binding site [ion binding]; metal-binding site 683837002284 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 683837002285 DEAD-like helicases superfamily; Region: DEXDc; smart00487 683837002286 ATP binding site [chemical binding]; other site 683837002287 Mg++ binding site [ion binding]; other site 683837002288 motif III; other site 683837002289 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 683837002290 nucleotide binding region [chemical binding]; other site 683837002291 ATP-binding site [chemical binding]; other site 683837002292 QueT transporter; Region: QueT; cl01932 683837002293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 683837002294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 683837002295 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 683837002296 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 683837002297 Predicted transcriptional regulators [Transcription]; Region: COG1733 683837002298 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 683837002299 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 683837002300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837002301 putative substrate translocation pore; other site 683837002302 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 683837002303 PRD domain; Region: PRD; pfam00874 683837002304 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 683837002305 active site 683837002306 P-loop; other site 683837002307 phosphorylation site [posttranslational modification] 683837002308 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 683837002309 active site 683837002310 phosphorylation site [posttranslational modification] 683837002311 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 683837002312 methionine cluster; other site 683837002313 active site 683837002314 phosphorylation site [posttranslational modification] 683837002315 metal binding site [ion binding]; metal-binding site 683837002316 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 683837002317 active site 683837002318 P-loop; other site 683837002319 phosphorylation site [posttranslational modification] 683837002320 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 683837002321 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 683837002322 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 683837002323 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 683837002324 active site 683837002325 trimer interface [polypeptide binding]; other site 683837002326 allosteric site; other site 683837002327 active site lid [active] 683837002328 hexamer (dimer of trimers) interface [polypeptide binding]; other site 683837002329 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 683837002330 active site 683837002331 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 683837002332 catalytic tetrad [active] 683837002333 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 683837002334 Collagen binding domain; Region: Collagen_bind; pfam05737 683837002335 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 683837002336 Uncharacterized conserved protein [Function unknown]; Region: COG3402 683837002337 Predicted membrane protein [Function unknown]; Region: COG3428 683837002338 Bacterial PH domain; Region: DUF304; pfam03703 683837002339 Bacterial PH domain; Region: DUF304; pfam03703 683837002340 Bacterial PH domain; Region: DUF304; pfam03703 683837002341 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 683837002342 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 683837002343 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 683837002344 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 683837002345 active site 683837002346 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 683837002347 dimer interface [polypeptide binding]; other site 683837002348 substrate binding site [chemical binding]; other site 683837002349 catalytic residues [active] 683837002350 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 683837002351 PemK-like protein; Region: PemK; pfam02452 683837002352 Rsbr N terminal; Region: Rsbr_N; pfam08678 683837002353 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 683837002354 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 683837002355 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 683837002356 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 683837002357 ATP binding site [chemical binding]; other site 683837002358 Mg2+ binding site [ion binding]; other site 683837002359 G-X-G motif; other site 683837002360 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 683837002361 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 683837002362 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 683837002363 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 683837002364 anti sigma factor interaction site; other site 683837002365 regulatory phosphorylation site [posttranslational modification]; other site 683837002366 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 683837002367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837002368 ATP binding site [chemical binding]; other site 683837002369 Mg2+ binding site [ion binding]; other site 683837002370 G-X-G motif; other site 683837002371 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 683837002372 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 683837002373 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 683837002374 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 683837002375 DNA binding residues [nucleotide binding] 683837002376 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 683837002377 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 683837002378 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 683837002379 Sulfate transporter family; Region: Sulfate_transp; pfam00916 683837002380 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 683837002381 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 683837002382 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 683837002383 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 683837002384 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 683837002385 RNA binding site [nucleotide binding]; other site 683837002386 hypothetical protein; Provisional; Region: PRK04351 683837002387 SprT homologues; Region: SprT; cl01182 683837002388 Uncharacterized conserved protein [Function unknown]; Region: COG5646 683837002389 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 683837002390 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 683837002391 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 683837002392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837002393 DNA-binding site [nucleotide binding]; DNA binding site 683837002394 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 683837002395 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 683837002396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 683837002397 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 683837002398 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 683837002399 glutathione reductase; Validated; Region: PRK06116 683837002400 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 683837002401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 683837002402 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 683837002403 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 683837002404 catalytic core [active] 683837002405 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 683837002406 Domain of unknown function DUF20; Region: UPF0118; pfam01594 683837002407 Predicted transcriptional regulators [Transcription]; Region: COG1725 683837002408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837002409 DNA-binding site [nucleotide binding]; DNA binding site 683837002410 Predicted membrane protein [General function prediction only]; Region: COG4194 683837002411 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 683837002412 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 683837002413 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 683837002414 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 683837002415 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 683837002416 tetramerization interface [polypeptide binding]; other site 683837002417 NAD(P) binding site [chemical binding]; other site 683837002418 catalytic residues [active] 683837002419 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 683837002420 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 683837002421 ABC transporter; Region: ABC_tran_2; pfam12848 683837002422 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 683837002423 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 683837002424 Predicted permeases [General function prediction only]; Region: COG0701 683837002425 Predicted membrane protein [Function unknown]; Region: COG3689 683837002426 pantothenate kinase; Provisional; Region: PRK05439 683837002427 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 683837002428 ATP-binding site [chemical binding]; other site 683837002429 CoA-binding site [chemical binding]; other site 683837002430 Mg2+-binding site [ion binding]; other site 683837002431 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 683837002432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837002433 Walker A/P-loop; other site 683837002434 ATP binding site [chemical binding]; other site 683837002435 Q-loop/lid; other site 683837002436 ABC transporter signature motif; other site 683837002437 Walker B; other site 683837002438 D-loop; other site 683837002439 H-loop/switch region; other site 683837002440 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 683837002441 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 683837002442 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 683837002443 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 683837002444 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 683837002445 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 683837002446 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 683837002447 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 683837002448 Sulfatase; Region: Sulfatase; pfam00884 683837002449 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 683837002450 active site 683837002451 DNA binding site [nucleotide binding] 683837002452 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 683837002453 active site 683837002454 catalytic site [active] 683837002455 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 683837002456 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 683837002457 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 683837002458 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 683837002459 Uncharacterized conserved protein [Function unknown]; Region: COG0398 683837002460 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 683837002461 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 683837002462 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 683837002463 Ligand binding site; other site 683837002464 Putative Catalytic site; other site 683837002465 DXD motif; other site 683837002466 epoxyqueuosine reductase; Region: TIGR00276 683837002467 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 683837002468 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 683837002469 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 683837002470 dimer interface [polypeptide binding]; other site 683837002471 FMN binding site [chemical binding]; other site 683837002472 NADPH bind site [chemical binding]; other site 683837002473 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 683837002474 Low molecular weight phosphatase family; Region: LMWPc; cd00115 683837002475 active site 683837002476 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 683837002477 HSP90 family protein; Provisional; Region: PRK14083 683837002478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837002479 ATP binding site [chemical binding]; other site 683837002480 Mg2+ binding site [ion binding]; other site 683837002481 G-X-G motif; other site 683837002482 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 683837002483 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 683837002484 dimerization interface [polypeptide binding]; other site 683837002485 DPS ferroxidase diiron center [ion binding]; other site 683837002486 ion pore; other site 683837002487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 683837002488 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 683837002489 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 683837002490 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 683837002491 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 683837002492 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 683837002493 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 683837002494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837002495 putative substrate translocation pore; other site 683837002496 Transcriptional regulators [Transcription]; Region: FadR; COG2186 683837002497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837002498 DNA-binding site [nucleotide binding]; DNA binding site 683837002499 FCD domain; Region: FCD; pfam07729 683837002500 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 683837002501 Domain of unknown function DUF20; Region: UPF0118; pfam01594 683837002502 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 683837002503 Lipase (class 2); Region: Lipase_2; pfam01674 683837002504 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 683837002505 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 683837002506 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 683837002507 Predicted transcriptional regulators [Transcription]; Region: COG1733 683837002508 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 683837002509 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 683837002510 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 683837002511 Predicted flavoprotein [General function prediction only]; Region: COG0431 683837002512 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 683837002513 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837002514 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837002515 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 683837002516 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 683837002517 active site 683837002518 dimer interface [polypeptide binding]; other site 683837002519 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 683837002520 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 683837002521 active site 683837002522 trimer interface [polypeptide binding]; other site 683837002523 allosteric site; other site 683837002524 active site lid [active] 683837002525 hexamer (dimer of trimers) interface [polypeptide binding]; other site 683837002526 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 683837002527 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837002528 DNA-binding site [nucleotide binding]; DNA binding site 683837002529 UTRA domain; Region: UTRA; pfam07702 683837002530 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 683837002531 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 683837002532 Mg++ binding site [ion binding]; other site 683837002533 putative catalytic motif [active] 683837002534 substrate binding site [chemical binding]; other site 683837002535 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 683837002536 Peptidase family U32; Region: Peptidase_U32; pfam01136 683837002537 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 683837002538 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 683837002539 Peptidase family U32; Region: Peptidase_U32; pfam01136 683837002540 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 683837002541 heat shock protein HtpX; Provisional; Region: PRK04897 683837002542 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 683837002543 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 683837002544 catalytic residues [active] 683837002545 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 683837002546 putative active site [active] 683837002547 putative metal binding residues [ion binding]; other site 683837002548 signature motif; other site 683837002549 putative triphosphate binding site [ion binding]; other site 683837002550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 683837002551 TPR motif; other site 683837002552 binding surface 683837002553 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 683837002554 synthetase active site [active] 683837002555 NTP binding site [chemical binding]; other site 683837002556 metal binding site [ion binding]; metal-binding site 683837002557 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 683837002558 ATP-NAD kinase; Region: NAD_kinase; pfam01513 683837002559 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 683837002560 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 683837002561 active site 683837002562 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 683837002563 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 683837002564 NAD binding site [chemical binding]; other site 683837002565 homotetramer interface [polypeptide binding]; other site 683837002566 homodimer interface [polypeptide binding]; other site 683837002567 substrate binding site [chemical binding]; other site 683837002568 active site 683837002569 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 683837002570 DltD N-terminal region; Region: DltD_N; pfam04915 683837002571 DltD central region; Region: DltD_M; pfam04918 683837002572 DltD C-terminal region; Region: DltD_C; pfam04914 683837002573 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 683837002574 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 683837002575 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 683837002576 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 683837002577 acyl-activating enzyme (AAE) consensus motif; other site 683837002578 AMP binding site [chemical binding]; other site 683837002579 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 683837002580 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 683837002581 tetramer (dimer of dimers) interface [polypeptide binding]; other site 683837002582 active site 683837002583 dimer interface [polypeptide binding]; other site 683837002584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 683837002585 Coenzyme A binding pocket [chemical binding]; other site 683837002586 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 683837002587 Putative esterase; Region: Esterase; pfam00756 683837002588 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 683837002589 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 683837002590 homodimer interface [polypeptide binding]; other site 683837002591 substrate-cofactor binding pocket; other site 683837002592 catalytic residue [active] 683837002593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837002594 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837002595 putative substrate translocation pore; other site 683837002596 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 683837002597 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 683837002598 putative oligomer interface [polypeptide binding]; other site 683837002599 putative active site [active] 683837002600 metal binding site [ion binding]; metal-binding site 683837002601 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 683837002602 catalytic residues [active] 683837002603 dimer interface [polypeptide binding]; other site 683837002604 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 683837002605 LytTr DNA-binding domain; Region: LytTR; pfam04397 683837002606 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 683837002607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837002608 Walker A/P-loop; other site 683837002609 ATP binding site [chemical binding]; other site 683837002610 Q-loop/lid; other site 683837002611 ABC transporter signature motif; other site 683837002612 Walker B; other site 683837002613 D-loop; other site 683837002614 H-loop/switch region; other site 683837002615 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 683837002616 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 683837002617 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 683837002618 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 683837002619 G1 box; other site 683837002620 putative GEF interaction site [polypeptide binding]; other site 683837002621 GTP/Mg2+ binding site [chemical binding]; other site 683837002622 Switch I region; other site 683837002623 G2 box; other site 683837002624 G3 box; other site 683837002625 Switch II region; other site 683837002626 G4 box; other site 683837002627 G5 box; other site 683837002628 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 683837002629 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 683837002630 MarR family; Region: MarR_2; cl17246 683837002631 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 683837002632 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 683837002633 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 683837002634 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 683837002635 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 683837002636 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 683837002637 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 683837002638 Acyltransferase family; Region: Acyl_transf_3; pfam01757 683837002639 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 683837002640 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 683837002641 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 683837002642 DNA binding site [nucleotide binding] 683837002643 active site 683837002644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837002645 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 683837002646 Walker A motif; other site 683837002647 ATP binding site [chemical binding]; other site 683837002648 Walker B motif; other site 683837002649 arginine finger; other site 683837002650 UvrB/uvrC motif; Region: UVR; pfam02151 683837002651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837002652 Walker A motif; other site 683837002653 ATP binding site [chemical binding]; other site 683837002654 Walker B motif; other site 683837002655 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 683837002656 CAAX protease self-immunity; Region: Abi; pfam02517 683837002657 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 683837002658 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 683837002659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 683837002660 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 683837002661 dimerization domain swap beta strand [polypeptide binding]; other site 683837002662 regulatory protein interface [polypeptide binding]; other site 683837002663 active site 683837002664 regulatory phosphorylation site [posttranslational modification]; other site 683837002665 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 683837002666 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 683837002667 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 683837002668 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 683837002669 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 683837002670 Uncharacterized conserved protein [Function unknown]; Region: COG1434 683837002671 putative active site [active] 683837002672 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 683837002673 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 683837002674 aminotransferase A; Validated; Region: PRK07683 683837002675 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 683837002676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837002677 homodimer interface [polypeptide binding]; other site 683837002678 catalytic residue [active] 683837002679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 683837002680 FOG: CBS domain [General function prediction only]; Region: COG0517 683837002681 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 683837002682 Transcriptional regulator [Transcription]; Region: LysR; COG0583 683837002683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 683837002684 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 683837002685 dimerization interface [polypeptide binding]; other site 683837002686 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 683837002687 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 683837002688 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 683837002689 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 683837002690 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 683837002691 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 683837002692 metal binding site [ion binding]; metal-binding site 683837002693 putative dimer interface [polypeptide binding]; other site 683837002694 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 683837002695 Mechanosensitive ion channel; Region: MS_channel; pfam00924 683837002696 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 683837002697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837002698 Walker A/P-loop; other site 683837002699 ATP binding site [chemical binding]; other site 683837002700 Q-loop/lid; other site 683837002701 ABC transporter signature motif; other site 683837002702 Walker B; other site 683837002703 D-loop; other site 683837002704 H-loop/switch region; other site 683837002705 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 683837002706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837002707 dimer interface [polypeptide binding]; other site 683837002708 conserved gate region; other site 683837002709 putative PBP binding loops; other site 683837002710 ABC-ATPase subunit interface; other site 683837002711 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 683837002712 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 683837002713 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 683837002714 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 683837002715 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 683837002716 HPr interaction site; other site 683837002717 glycerol kinase (GK) interaction site [polypeptide binding]; other site 683837002718 active site 683837002719 phosphorylation site [posttranslational modification] 683837002720 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 683837002721 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 683837002722 S1 domain; Region: S1_2; pfam13509 683837002723 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 683837002724 RNA binding site [nucleotide binding]; other site 683837002725 Predicted membrane protein [Function unknown]; Region: COG4758 683837002726 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 683837002727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 683837002728 Histidine kinase; Region: HisKA_3; pfam07730 683837002729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837002730 ATP binding site [chemical binding]; other site 683837002731 Mg2+ binding site [ion binding]; other site 683837002732 G-X-G motif; other site 683837002733 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 683837002734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837002735 active site 683837002736 phosphorylation site [posttranslational modification] 683837002737 intermolecular recognition site; other site 683837002738 dimerization interface [polypeptide binding]; other site 683837002739 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 683837002740 DNA binding residues [nucleotide binding] 683837002741 dimerization interface [polypeptide binding]; other site 683837002742 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 683837002743 TrkA-N domain; Region: TrkA_N; pfam02254 683837002744 TrkA-C domain; Region: TrkA_C; pfam02080 683837002745 Predicted membrane protein [Function unknown]; Region: COG1289 683837002746 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 683837002747 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 683837002748 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 683837002749 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 683837002750 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 683837002751 hypothetical protein; Provisional; Region: PRK13667 683837002752 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 683837002753 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837002754 active site 683837002755 motif I; other site 683837002756 motif II; other site 683837002757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837002758 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 683837002759 Leucine-rich repeats; other site 683837002760 Substrate binding site [chemical binding]; other site 683837002761 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837002762 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837002763 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 683837002764 Leucine-rich repeats; other site 683837002765 Substrate binding site [chemical binding]; other site 683837002766 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837002767 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837002768 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837002769 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837002770 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837002771 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 683837002772 Protein of unknown function (DUF817); Region: DUF817; pfam05675 683837002773 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 683837002774 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 683837002775 GTP binding site; other site 683837002776 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 683837002777 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 683837002778 Walker A/P-loop; other site 683837002779 ATP binding site [chemical binding]; other site 683837002780 Q-loop/lid; other site 683837002781 ABC transporter signature motif; other site 683837002782 Walker B; other site 683837002783 D-loop; other site 683837002784 H-loop/switch region; other site 683837002785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837002786 putative PBP binding loops; other site 683837002787 dimer interface [polypeptide binding]; other site 683837002788 ABC-ATPase subunit interface; other site 683837002789 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 683837002790 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 683837002791 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 683837002792 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 683837002793 dimer interface [polypeptide binding]; other site 683837002794 putative functional site; other site 683837002795 putative MPT binding site; other site 683837002796 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 683837002797 Walker A motif; other site 683837002798 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 683837002799 MoaE homodimer interface [polypeptide binding]; other site 683837002800 MoaD interaction [polypeptide binding]; other site 683837002801 active site residues [active] 683837002802 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 683837002803 MoaE interaction surface [polypeptide binding]; other site 683837002804 MoeB interaction surface [polypeptide binding]; other site 683837002805 thiocarboxylated glycine; other site 683837002806 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 683837002807 trimer interface [polypeptide binding]; other site 683837002808 dimer interface [polypeptide binding]; other site 683837002809 putative active site [active] 683837002810 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 683837002811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 683837002812 FeS/SAM binding site; other site 683837002813 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 683837002814 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 683837002815 MPT binding site; other site 683837002816 trimer interface [polypeptide binding]; other site 683837002817 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 683837002818 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 683837002819 ATP binding site [chemical binding]; other site 683837002820 substrate interface [chemical binding]; other site 683837002821 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 683837002822 active site 683837002823 catalytic residues [active] 683837002824 metal binding site [ion binding]; metal-binding site 683837002825 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 683837002826 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 683837002827 TPP-binding site [chemical binding]; other site 683837002828 tetramer interface [polypeptide binding]; other site 683837002829 heterodimer interface [polypeptide binding]; other site 683837002830 phosphorylation loop region [posttranslational modification] 683837002831 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 683837002832 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 683837002833 alpha subunit interface [polypeptide binding]; other site 683837002834 TPP binding site [chemical binding]; other site 683837002835 heterodimer interface [polypeptide binding]; other site 683837002836 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 683837002837 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 683837002838 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 683837002839 E3 interaction surface; other site 683837002840 lipoyl attachment site [posttranslational modification]; other site 683837002841 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 683837002842 E3 interaction surface; other site 683837002843 lipoyl attachment site [posttranslational modification]; other site 683837002844 e3 binding domain; Region: E3_binding; pfam02817 683837002845 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 683837002846 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 683837002847 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 683837002848 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 683837002849 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 683837002850 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 683837002851 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 683837002852 NAD(P) binding site [chemical binding]; other site 683837002853 LDH/MDH dimer interface [polypeptide binding]; other site 683837002854 substrate binding site [chemical binding]; other site 683837002855 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 683837002856 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 683837002857 Thioredoxin; Region: Thioredoxin_4; pfam13462 683837002858 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 683837002859 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 683837002860 Cl binding site [ion binding]; other site 683837002861 oligomer interface [polypeptide binding]; other site 683837002862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 683837002863 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 683837002864 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 683837002865 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 683837002866 active site 683837002867 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 683837002868 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 683837002869 G1 box; other site 683837002870 putative GEF interaction site [polypeptide binding]; other site 683837002871 GTP/Mg2+ binding site [chemical binding]; other site 683837002872 Switch I region; other site 683837002873 G2 box; other site 683837002874 G3 box; other site 683837002875 Switch II region; other site 683837002876 G4 box; other site 683837002877 G5 box; other site 683837002878 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 683837002879 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 683837002880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 683837002881 hypothetical protein; Provisional; Region: PRK13666 683837002882 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 683837002883 pyruvate carboxylase; Reviewed; Region: PRK12999 683837002884 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 683837002885 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 683837002886 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 683837002887 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 683837002888 active site 683837002889 catalytic residues [active] 683837002890 metal binding site [ion binding]; metal-binding site 683837002891 homodimer binding site [polypeptide binding]; other site 683837002892 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 683837002893 carboxyltransferase (CT) interaction site; other site 683837002894 biotinylation site [posttranslational modification]; other site 683837002895 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 683837002896 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 683837002897 putative binding site residues; other site 683837002898 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 683837002899 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 683837002900 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 683837002901 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 683837002902 Walker A/P-loop; other site 683837002903 ATP binding site [chemical binding]; other site 683837002904 Q-loop/lid; other site 683837002905 ABC transporter signature motif; other site 683837002906 Walker B; other site 683837002907 D-loop; other site 683837002908 H-loop/switch region; other site 683837002909 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 683837002910 SH3-like domain; Region: SH3_8; pfam13457 683837002911 SH3-like domain; Region: SH3_8; pfam13457 683837002912 SH3-like domain; Region: SH3_8; pfam13457 683837002913 SH3-like domain; Region: SH3_8; pfam13457 683837002914 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 683837002915 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 683837002916 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 683837002917 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 683837002918 active site 683837002919 tetramer interface; other site 683837002920 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 683837002921 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 683837002922 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 683837002923 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 683837002924 active site 683837002925 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 683837002926 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 683837002927 substrate binding site; other site 683837002928 tetramer interface; other site 683837002929 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 683837002930 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 683837002931 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 683837002932 NAD binding site [chemical binding]; other site 683837002933 substrate binding site [chemical binding]; other site 683837002934 homodimer interface [polypeptide binding]; other site 683837002935 active site 683837002936 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 683837002937 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 683837002938 NADP binding site [chemical binding]; other site 683837002939 active site 683837002940 putative substrate binding site [chemical binding]; other site 683837002941 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 683837002942 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 683837002943 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 683837002944 substrate binding site; other site 683837002945 dimer interface; other site 683837002946 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 683837002947 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 683837002948 putative NAD(P) binding site [chemical binding]; other site 683837002949 putative catalytic Zn binding site [ion binding]; other site 683837002950 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 683837002951 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 683837002952 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 683837002953 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 683837002954 active site 683837002955 putative glycosyl transferase; Provisional; Region: PRK10073 683837002956 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 683837002957 active site 683837002958 putative glycosyl transferase; Provisional; Region: PRK10073 683837002959 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 683837002960 active site 683837002961 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 683837002962 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 683837002963 active site 683837002964 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 683837002965 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 683837002966 homodimer interface [polypeptide binding]; other site 683837002967 NAD binding pocket [chemical binding]; other site 683837002968 ATP binding pocket [chemical binding]; other site 683837002969 Mg binding site [ion binding]; other site 683837002970 active-site loop [active] 683837002971 Uncharacterized conserved protein [Function unknown]; Region: COG1359 683837002972 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 683837002973 active site 683837002974 P-loop; other site 683837002975 phosphorylation site [posttranslational modification] 683837002976 GMP synthase; Reviewed; Region: guaA; PRK00074 683837002977 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 683837002978 AMP/PPi binding site [chemical binding]; other site 683837002979 candidate oxyanion hole; other site 683837002980 catalytic triad [active] 683837002981 potential glutamine specificity residues [chemical binding]; other site 683837002982 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 683837002983 ATP Binding subdomain [chemical binding]; other site 683837002984 Dimerization subdomain; other site 683837002985 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 683837002986 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 683837002987 DNA binding residues [nucleotide binding] 683837002988 dimer interface [polypeptide binding]; other site 683837002989 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 683837002990 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 683837002991 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 683837002992 LXG domain of WXG superfamily; Region: LXG; pfam04740 683837002993 LXG domain of WXG superfamily; Region: LXG; pfam04740 683837002994 Isochorismatase family; Region: Isochorismatase; pfam00857 683837002995 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 683837002996 catalytic triad [active] 683837002997 conserved cis-peptide bond; other site 683837002998 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 683837002999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 683837003000 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 683837003001 Coenzyme A binding pocket [chemical binding]; other site 683837003002 MepB protein; Region: MepB; pfam08877 683837003003 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 683837003004 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 683837003005 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 683837003006 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 683837003007 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 683837003008 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 683837003009 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 683837003010 Walker A/P-loop; other site 683837003011 ATP binding site [chemical binding]; other site 683837003012 Q-loop/lid; other site 683837003013 ABC transporter signature motif; other site 683837003014 Walker B; other site 683837003015 D-loop; other site 683837003016 H-loop/switch region; other site 683837003017 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 683837003018 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 683837003019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837003020 Walker A/P-loop; other site 683837003021 ATP binding site [chemical binding]; other site 683837003022 Q-loop/lid; other site 683837003023 ABC transporter signature motif; other site 683837003024 Walker B; other site 683837003025 D-loop; other site 683837003026 H-loop/switch region; other site 683837003027 Uncharacterized conserved protein [Function unknown]; Region: COG1359 683837003028 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 683837003029 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 683837003030 DNA binding residues [nucleotide binding] 683837003031 putative dimer interface [polypeptide binding]; other site 683837003032 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 683837003033 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 683837003034 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 683837003035 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 683837003036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 683837003037 Clp protease; Region: CLP_protease; pfam00574 683837003038 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 683837003039 oligomer interface [polypeptide binding]; other site 683837003040 active site residues [active] 683837003041 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 683837003042 dimer interface [polypeptide binding]; other site 683837003043 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 683837003044 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 683837003045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 683837003046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 683837003047 Bacterial transcriptional repressor; Region: TetR; pfam13972 683837003048 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 683837003049 short chain dehydrogenase; Provisional; Region: PRK06197 683837003050 putative NAD(P) binding site [chemical binding]; other site 683837003051 active site 683837003052 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 683837003053 SLBB domain; Region: SLBB; pfam10531 683837003054 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 683837003055 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 683837003056 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 683837003057 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 683837003058 putative hexamer interface [polypeptide binding]; other site 683837003059 putative hexagonal pore; other site 683837003060 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 683837003061 putative hexamer interface [polypeptide binding]; other site 683837003062 putative hexagonal pore; other site 683837003063 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 683837003064 putative hexamer interface [polypeptide binding]; other site 683837003065 putative hexagonal pore; other site 683837003066 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 683837003067 G1 box; other site 683837003068 GTP/Mg2+ binding site [chemical binding]; other site 683837003069 Switch I region; other site 683837003070 G3 box; other site 683837003071 Switch II region; other site 683837003072 G4 box; other site 683837003073 G5 box; other site 683837003074 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 683837003075 homotrimer interface [polypeptide binding]; other site 683837003076 Walker A motif; other site 683837003077 GTP binding site [chemical binding]; other site 683837003078 Walker B motif; other site 683837003079 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 683837003080 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 683837003081 catalytic core [active] 683837003082 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 683837003083 Sensory domain found in PocR; Region: PocR; pfam10114 683837003084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 683837003085 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 683837003086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 683837003087 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 683837003088 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 683837003089 Hexamer interface [polypeptide binding]; other site 683837003090 Hexagonal pore residue; other site 683837003091 propanediol utilization protein PduB; Provisional; Region: PRK15415 683837003092 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 683837003093 putative hexamer interface [polypeptide binding]; other site 683837003094 putative hexagonal pore; other site 683837003095 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 683837003096 putative hexamer interface [polypeptide binding]; other site 683837003097 putative hexagonal pore; other site 683837003098 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 683837003099 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 683837003100 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 683837003101 alpha-beta subunit interface [polypeptide binding]; other site 683837003102 alpha-gamma subunit interface [polypeptide binding]; other site 683837003103 active site 683837003104 substrate and K+ binding site; other site 683837003105 K+ binding site [ion binding]; other site 683837003106 cobalamin binding site [chemical binding]; other site 683837003107 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 683837003108 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 683837003109 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 683837003110 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 683837003111 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 683837003112 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 683837003113 putative hexamer interface [polypeptide binding]; other site 683837003114 putative hexagonal pore; other site 683837003115 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 683837003116 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 683837003117 Hexamer interface [polypeptide binding]; other site 683837003118 Hexagonal pore residue; other site 683837003119 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 683837003120 Propanediol utilisation protein PduL; Region: PduL; pfam06130 683837003121 Propanediol utilisation protein PduL; Region: PduL; pfam06130 683837003122 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 683837003123 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 683837003124 nucleotide binding site [chemical binding]; other site 683837003125 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 683837003126 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 683837003127 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 683837003128 Hexamer/Pentamer interface [polypeptide binding]; other site 683837003129 central pore; other site 683837003130 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 683837003131 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 683837003132 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 683837003133 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 683837003134 putative catalytic cysteine [active] 683837003135 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 683837003136 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 683837003137 putative active site [active] 683837003138 metal binding site [ion binding]; metal-binding site 683837003139 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 683837003140 amphipathic channel; other site 683837003141 Asn-Pro-Ala signature motifs; other site 683837003142 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 683837003143 propionate/acetate kinase; Provisional; Region: PRK12379 683837003144 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 683837003145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 683837003146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837003147 homodimer interface [polypeptide binding]; other site 683837003148 catalytic residue [active] 683837003149 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 683837003150 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 683837003151 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 683837003152 putative active site [active] 683837003153 metal binding site [ion binding]; metal-binding site 683837003154 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 683837003155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837003156 active site 683837003157 phosphorylation site [posttranslational modification] 683837003158 intermolecular recognition site; other site 683837003159 dimerization interface [polypeptide binding]; other site 683837003160 ANTAR domain; Region: ANTAR; pfam03861 683837003161 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 683837003162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 683837003163 Histidine kinase; Region: HisKA_2; pfam07568 683837003164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837003165 ATP binding site [chemical binding]; other site 683837003166 Mg2+ binding site [ion binding]; other site 683837003167 G-X-G motif; other site 683837003168 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 683837003169 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 683837003170 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 683837003171 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 683837003172 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 683837003173 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 683837003174 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 683837003175 putative hexamer interface [polypeptide binding]; other site 683837003176 putative hexagonal pore; other site 683837003177 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 683837003178 putative hexamer interface [polypeptide binding]; other site 683837003179 putative hexagonal pore; other site 683837003180 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 683837003181 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 683837003182 Hexamer interface [polypeptide binding]; other site 683837003183 Hexagonal pore residue; other site 683837003184 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 683837003185 putative catalytic cysteine [active] 683837003186 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 683837003187 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 683837003188 Hexamer interface [polypeptide binding]; other site 683837003189 Putative hexagonal pore residue; other site 683837003190 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 683837003191 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 683837003192 Propanediol utilisation protein PduL; Region: PduL; pfam06130 683837003193 Propanediol utilisation protein PduL; Region: PduL; pfam06130 683837003194 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 683837003195 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 683837003196 Hexamer/Pentamer interface [polypeptide binding]; other site 683837003197 central pore; other site 683837003198 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 683837003199 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 683837003200 putative hexamer interface [polypeptide binding]; other site 683837003201 putative hexagonal pore; other site 683837003202 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 683837003203 putative hexamer interface [polypeptide binding]; other site 683837003204 putative hexagonal pore; other site 683837003205 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 683837003206 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 683837003207 hypothetical protein; Region: PHA01818 683837003208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 683837003209 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 683837003210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 683837003211 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 683837003212 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 683837003213 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 683837003214 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 683837003215 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 683837003216 catalytic triad [active] 683837003217 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 683837003218 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 683837003219 Precorrin-8X methylmutase; Region: CbiC; pfam02570 683837003220 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 683837003221 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 683837003222 active site 683837003223 putative homodimer interface [polypeptide binding]; other site 683837003224 SAM binding site [chemical binding]; other site 683837003225 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 683837003226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837003227 S-adenosylmethionine binding site [chemical binding]; other site 683837003228 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 683837003229 active site 683837003230 SAM binding site [chemical binding]; other site 683837003231 homodimer interface [polypeptide binding]; other site 683837003232 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 683837003233 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 683837003234 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 683837003235 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 683837003236 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 683837003237 active site 683837003238 SAM binding site [chemical binding]; other site 683837003239 homodimer interface [polypeptide binding]; other site 683837003240 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 683837003241 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 683837003242 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 683837003243 active site 683837003244 SAM binding site [chemical binding]; other site 683837003245 homodimer interface [polypeptide binding]; other site 683837003246 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 683837003247 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 683837003248 active site 683837003249 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 683837003250 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 683837003251 active site 683837003252 C-terminal domain interface [polypeptide binding]; other site 683837003253 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 683837003254 active site 683837003255 N-terminal domain interface [polypeptide binding]; other site 683837003256 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 683837003257 active site 683837003258 SAM binding site [chemical binding]; other site 683837003259 homodimer interface [polypeptide binding]; other site 683837003260 cobalt transport protein CbiM; Validated; Region: PRK08319 683837003261 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 683837003262 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 683837003263 cobalt transport protein CbiQ; Provisional; Region: PRK15485 683837003264 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 683837003265 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 683837003266 Walker A/P-loop; other site 683837003267 ATP binding site [chemical binding]; other site 683837003268 Q-loop/lid; other site 683837003269 ABC transporter signature motif; other site 683837003270 Walker B; other site 683837003271 D-loop; other site 683837003272 H-loop/switch region; other site 683837003273 cobyric acid synthase; Provisional; Region: PRK00784 683837003274 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 683837003275 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 683837003276 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 683837003277 catalytic triad [active] 683837003278 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 683837003279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 683837003280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 683837003281 topology modulation protein; Reviewed; Region: PRK08118 683837003282 AAA domain; Region: AAA_17; pfam13207 683837003283 Predicted transcriptional regulators [Transcription]; Region: COG1695 683837003284 Transcriptional regulator PadR-like family; Region: PadR; cl17335 683837003285 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 683837003286 Predicted transcriptional regulator [Transcription]; Region: COG1959 683837003287 Transcriptional regulator; Region: Rrf2; pfam02082 683837003288 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 683837003289 NADH(P)-binding; Region: NAD_binding_10; pfam13460 683837003290 NAD binding site [chemical binding]; other site 683837003291 substrate binding site [chemical binding]; other site 683837003292 putative active site [active] 683837003293 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 683837003294 SH3-like domain; Region: SH3_8; pfam13457 683837003295 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 683837003296 SH3-like domain; Region: SH3_8; pfam13457 683837003297 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 683837003298 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 683837003299 oligomer interface [polypeptide binding]; other site 683837003300 active site 683837003301 metal binding site [ion binding]; metal-binding site 683837003302 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 683837003303 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 683837003304 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 683837003305 Predicted transcriptional regulators [Transcription]; Region: COG1733 683837003306 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 683837003307 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 683837003308 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 683837003309 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 683837003310 dimer interface [polypeptide binding]; other site 683837003311 motif 1; other site 683837003312 active site 683837003313 motif 2; other site 683837003314 motif 3; other site 683837003315 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 683837003316 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 683837003317 putative tRNA-binding site [nucleotide binding]; other site 683837003318 B3/4 domain; Region: B3_4; pfam03483 683837003319 tRNA synthetase B5 domain; Region: B5; smart00874 683837003320 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 683837003321 dimer interface [polypeptide binding]; other site 683837003322 motif 1; other site 683837003323 motif 3; other site 683837003324 motif 2; other site 683837003325 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 683837003326 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 683837003327 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 683837003328 Walker A/P-loop; other site 683837003329 ATP binding site [chemical binding]; other site 683837003330 Q-loop/lid; other site 683837003331 ABC transporter signature motif; other site 683837003332 Walker B; other site 683837003333 D-loop; other site 683837003334 H-loop/switch region; other site 683837003335 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 683837003336 FtsX-like permease family; Region: FtsX; pfam02687 683837003337 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 683837003338 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 683837003339 FtsX-like permease family; Region: FtsX; pfam02687 683837003340 Transcriptional regulators [Transcription]; Region: MarR; COG1846 683837003341 MarR family; Region: MarR; pfam01047 683837003342 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 683837003343 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 683837003344 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 683837003345 ligand binding site [chemical binding]; other site 683837003346 active site 683837003347 UGI interface [polypeptide binding]; other site 683837003348 catalytic site [active] 683837003349 ribonuclease HIII; Provisional; Region: PRK00996 683837003350 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 683837003351 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 683837003352 RNA/DNA hybrid binding site [nucleotide binding]; other site 683837003353 active site 683837003354 Cell division protein ZapA; Region: ZapA; cl01146 683837003355 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 683837003356 Colicin V production protein; Region: Colicin_V; pfam02674 683837003357 hypothetical protein; Provisional; Region: PRK08609 683837003358 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 683837003359 active site 683837003360 primer binding site [nucleotide binding]; other site 683837003361 NTP binding site [chemical binding]; other site 683837003362 metal binding triad [ion binding]; metal-binding site 683837003363 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 683837003364 active site 683837003365 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 683837003366 MutS domain III; Region: MutS_III; pfam05192 683837003367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837003368 Walker A/P-loop; other site 683837003369 ATP binding site [chemical binding]; other site 683837003370 Q-loop/lid; other site 683837003371 ABC transporter signature motif; other site 683837003372 Walker B; other site 683837003373 D-loop; other site 683837003374 H-loop/switch region; other site 683837003375 Smr domain; Region: Smr; pfam01713 683837003376 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 683837003377 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 683837003378 catalytic residues [active] 683837003379 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 683837003380 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 683837003381 GIY-YIG motif/motif A; other site 683837003382 active site 683837003383 catalytic site [active] 683837003384 putative DNA binding site [nucleotide binding]; other site 683837003385 metal binding site [ion binding]; metal-binding site 683837003386 UvrB/uvrC motif; Region: UVR; pfam02151 683837003387 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 683837003388 aspartate kinase; Reviewed; Region: PRK06635 683837003389 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 683837003390 putative nucleotide binding site [chemical binding]; other site 683837003391 putative catalytic residues [active] 683837003392 putative Mg ion binding site [ion binding]; other site 683837003393 putative aspartate binding site [chemical binding]; other site 683837003394 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 683837003395 putative allosteric regulatory site; other site 683837003396 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 683837003397 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 683837003398 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 683837003399 ribonuclease PH; Reviewed; Region: rph; PRK00173 683837003400 Ribonuclease PH; Region: RNase_PH_bact; cd11362 683837003401 hexamer interface [polypeptide binding]; other site 683837003402 active site 683837003403 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 683837003404 active site 683837003405 dimerization interface [polypeptide binding]; other site 683837003406 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 683837003407 active site 683837003408 metal binding site [ion binding]; metal-binding site 683837003409 homotetramer interface [polypeptide binding]; other site 683837003410 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 683837003411 DNA binding site [nucleotide binding] 683837003412 active site 683837003413 Int/Topo IB signature motif; other site 683837003414 potential frameshift: common BLAST hit: gi|152974247|ref|YP_001373764.1| Cna B domain-containing protein 683837003415 potential frameshift: common BLAST hit: gi|217964622|ref|YP_002350300.1| Cna B domain protein 683837003416 Cna protein B-type domain; Region: Cna_B; pfam05738 683837003417 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 683837003418 LytTr DNA-binding domain; Region: LytTR; pfam04397 683837003419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837003420 non-specific DNA binding site [nucleotide binding]; other site 683837003421 salt bridge; other site 683837003422 sequence-specific DNA binding site [nucleotide binding]; other site 683837003423 CAAX protease self-immunity; Region: Abi; pfam02517 683837003424 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 683837003425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837003426 active site 683837003427 motif I; other site 683837003428 motif II; other site 683837003429 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 683837003430 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 683837003431 S-adenosylmethionine synthetase; Provisional; Region: PRK04439 683837003432 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 683837003433 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 683837003434 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 683837003435 catalytic residue [active] 683837003436 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 683837003437 classical (c) SDRs; Region: SDR_c; cd05233 683837003438 NAD(P) binding site [chemical binding]; other site 683837003439 active site 683837003440 AAA domain; Region: AAA_17; pfam13207 683837003441 AAA domain; Region: AAA_18; pfam13238 683837003442 Survival protein SurE; Region: SurE; pfam01975 683837003443 Phosphotransferase enzyme family; Region: APH; pfam01636 683837003444 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 683837003445 nudix motif; other site 683837003446 Transposase, Mutator family; Region: Transposase_mut; pfam00872 683837003447 MULE transposase domain; Region: MULE; pfam10551 683837003448 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 683837003449 active site 683837003450 Int/Topo IB signature motif; other site 683837003451 LXG domain of WXG superfamily; Region: LXG; pfam04740 683837003452 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 683837003453 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 683837003454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 683837003455 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 683837003456 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 683837003457 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 683837003458 dimer interface [polypeptide binding]; other site 683837003459 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 683837003460 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 683837003461 catalytic core [active] 683837003462 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 683837003463 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 683837003464 ATP binding site [chemical binding]; other site 683837003465 Mg++ binding site [ion binding]; other site 683837003466 motif III; other site 683837003467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 683837003468 nucleotide binding region [chemical binding]; other site 683837003469 ATP-binding site [chemical binding]; other site 683837003470 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 683837003471 RNA binding site [nucleotide binding]; other site 683837003472 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 683837003473 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 683837003474 putative active site [active] 683837003475 nucleotide binding site [chemical binding]; other site 683837003476 nudix motif; other site 683837003477 putative metal binding site [ion binding]; other site 683837003478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837003479 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837003480 putative substrate translocation pore; other site 683837003481 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837003482 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 683837003483 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 683837003484 ligand binding site [chemical binding]; other site 683837003485 flexible hinge region; other site 683837003486 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 683837003487 Uncharacterized conserved protein [Function unknown]; Region: COG1284 683837003488 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 683837003489 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 683837003490 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 683837003491 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837003492 DNA-binding site [nucleotide binding]; DNA binding site 683837003493 UTRA domain; Region: UTRA; pfam07702 683837003496 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 683837003497 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 683837003498 active site turn [active] 683837003499 phosphorylation site [posttranslational modification] 683837003500 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 683837003501 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 683837003502 nudix motif; other site 683837003503 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 683837003504 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 683837003505 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 683837003506 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 683837003507 putative catalytic cysteine [active] 683837003508 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 683837003509 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 683837003510 nucleotide binding site [chemical binding]; other site 683837003511 homotetrameric interface [polypeptide binding]; other site 683837003512 putative phosphate binding site [ion binding]; other site 683837003513 putative allosteric binding site; other site 683837003514 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 683837003515 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 683837003516 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 683837003517 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837003518 non-specific DNA binding site [nucleotide binding]; other site 683837003519 salt bridge; other site 683837003520 sequence-specific DNA binding site [nucleotide binding]; other site 683837003521 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837003522 non-specific DNA binding site [nucleotide binding]; other site 683837003523 salt bridge; other site 683837003524 sequence-specific DNA binding site [nucleotide binding]; other site 683837003525 trigger factor; Provisional; Region: tig; PRK01490 683837003526 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 683837003527 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 683837003528 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 683837003529 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 683837003530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837003531 Walker A motif; other site 683837003532 ATP binding site [chemical binding]; other site 683837003533 Walker B motif; other site 683837003534 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 683837003535 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 683837003536 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 683837003537 Catalytic site [active] 683837003538 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 683837003539 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 683837003540 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 683837003541 Catalytic site [active] 683837003542 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 683837003543 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 683837003544 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 683837003545 Catalytic site [active] 683837003546 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 683837003547 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 683837003548 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 683837003549 GTP/Mg2+ binding site [chemical binding]; other site 683837003550 G4 box; other site 683837003551 G5 box; other site 683837003552 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 683837003553 G1 box; other site 683837003554 G1 box; other site 683837003555 GTP/Mg2+ binding site [chemical binding]; other site 683837003556 Switch I region; other site 683837003557 G2 box; other site 683837003558 G2 box; other site 683837003559 G3 box; other site 683837003560 G3 box; other site 683837003561 Switch II region; other site 683837003562 Switch II region; other site 683837003563 G5 box; other site 683837003564 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 683837003565 RNA/DNA hybrid binding site [nucleotide binding]; other site 683837003566 active site 683837003567 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 683837003568 DNA protecting protein DprA; Region: dprA; TIGR00732 683837003569 DNA topoisomerase I; Validated; Region: PRK05582 683837003570 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 683837003571 active site 683837003572 interdomain interaction site; other site 683837003573 putative metal-binding site [ion binding]; other site 683837003574 nucleotide binding site [chemical binding]; other site 683837003575 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 683837003576 domain I; other site 683837003577 DNA binding groove [nucleotide binding] 683837003578 phosphate binding site [ion binding]; other site 683837003579 domain II; other site 683837003580 domain III; other site 683837003581 nucleotide binding site [chemical binding]; other site 683837003582 catalytic site [active] 683837003583 domain IV; other site 683837003584 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 683837003585 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 683837003586 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 683837003587 Glucose inhibited division protein A; Region: GIDA; pfam01134 683837003588 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 683837003589 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 683837003590 active site 683837003591 DNA binding site [nucleotide binding] 683837003592 Int/Topo IB signature motif; other site 683837003593 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 683837003594 active site 683837003595 HslU subunit interaction site [polypeptide binding]; other site 683837003596 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 683837003597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837003598 Walker A motif; other site 683837003599 ATP binding site [chemical binding]; other site 683837003600 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 683837003601 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 683837003602 transcriptional repressor CodY; Validated; Region: PRK04158 683837003603 CodY GAF-like domain; Region: CodY; pfam06018 683837003604 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 683837003605 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 683837003606 active site 683837003607 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 683837003608 active site 683837003609 catalytic residues [active] 683837003610 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 683837003611 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 683837003612 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 683837003613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837003614 Mg2+ binding site [ion binding]; other site 683837003615 G-X-G motif; other site 683837003616 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 683837003617 anchoring element; other site 683837003618 dimer interface [polypeptide binding]; other site 683837003619 ATP binding site [chemical binding]; other site 683837003620 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 683837003621 active site 683837003622 putative metal-binding site [ion binding]; other site 683837003623 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 683837003624 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 683837003625 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 683837003626 CAP-like domain; other site 683837003627 active site 683837003628 primary dimer interface [polypeptide binding]; other site 683837003629 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 683837003630 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 683837003631 S-ribosylhomocysteinase; Provisional; Region: PRK02260 683837003632 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 683837003633 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 683837003634 catalytic triad [active] 683837003635 catalytic triad [active] 683837003636 oxyanion hole [active] 683837003637 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 683837003638 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 683837003639 active site 683837003640 catalytic site [active] 683837003641 metal binding site [ion binding]; metal-binding site 683837003642 dimer interface [polypeptide binding]; other site 683837003643 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 683837003644 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 683837003645 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 683837003646 bacterial Hfq-like; Region: Hfq; cd01716 683837003647 hexamer interface [polypeptide binding]; other site 683837003648 Sm1 motif; other site 683837003649 RNA binding site [nucleotide binding]; other site 683837003650 Sm2 motif; other site 683837003651 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 683837003652 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 683837003653 HflX GTPase family; Region: HflX; cd01878 683837003654 G1 box; other site 683837003655 GTP/Mg2+ binding site [chemical binding]; other site 683837003656 Switch I region; other site 683837003657 G2 box; other site 683837003658 G3 box; other site 683837003659 Switch II region; other site 683837003660 G4 box; other site 683837003661 G5 box; other site 683837003662 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 683837003663 Aluminium resistance protein; Region: Alum_res; pfam06838 683837003664 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 683837003665 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 683837003666 DNA binding residues [nucleotide binding] 683837003667 putative dimer interface [polypeptide binding]; other site 683837003668 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 683837003669 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 683837003670 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 683837003671 arsenical pump membrane protein; Provisional; Region: PRK15445 683837003672 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 683837003673 transmembrane helices; other site 683837003674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 683837003675 LexA repressor; Validated; Region: PRK00215 683837003676 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 683837003677 putative DNA binding site [nucleotide binding]; other site 683837003678 putative Zn2+ binding site [ion binding]; other site 683837003679 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 683837003680 Catalytic site [active] 683837003681 cell division suppressor protein YneA; Provisional; Region: PRK14125 683837003682 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 683837003683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 683837003684 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 683837003685 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 683837003686 TPP-binding site [chemical binding]; other site 683837003687 dimer interface [polypeptide binding]; other site 683837003688 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 683837003689 PYR/PP interface [polypeptide binding]; other site 683837003690 dimer interface [polypeptide binding]; other site 683837003691 TPP binding site [chemical binding]; other site 683837003692 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 683837003693 hypothetical protein; Provisional; Region: PRK01844 683837003694 Methyltransferase domain; Region: Methyltransf_31; pfam13847 683837003695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837003696 S-adenosylmethionine binding site [chemical binding]; other site 683837003697 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 683837003698 ParB-like nuclease domain; Region: ParBc; pfam02195 683837003699 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 683837003700 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 683837003701 Active Sites [active] 683837003702 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 683837003703 DEAD-like helicases superfamily; Region: DEXDc; smart00487 683837003704 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 683837003705 putative nucleotide binding site [chemical binding]; other site 683837003706 uridine monophosphate binding site [chemical binding]; other site 683837003707 homohexameric interface [polypeptide binding]; other site 683837003708 ribosome recycling factor; Reviewed; Region: frr; PRK00083 683837003709 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 683837003710 hinge region; other site 683837003711 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 683837003712 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 683837003713 catalytic residue [active] 683837003714 putative FPP diphosphate binding site; other site 683837003715 putative FPP binding hydrophobic cleft; other site 683837003716 dimer interface [polypeptide binding]; other site 683837003717 putative IPP diphosphate binding site; other site 683837003718 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 683837003719 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 683837003720 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 683837003721 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 683837003722 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 683837003723 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 683837003724 RIP metalloprotease RseP; Region: TIGR00054 683837003725 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 683837003726 active site 683837003727 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 683837003728 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 683837003729 protein binding site [polypeptide binding]; other site 683837003730 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 683837003731 putative substrate binding region [chemical binding]; other site 683837003732 prolyl-tRNA synthetase; Provisional; Region: PRK09194 683837003733 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 683837003734 dimer interface [polypeptide binding]; other site 683837003735 motif 1; other site 683837003736 active site 683837003737 motif 2; other site 683837003738 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 683837003739 putative deacylase active site [active] 683837003740 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 683837003741 active site 683837003742 motif 3; other site 683837003743 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 683837003744 anticodon binding site; other site 683837003745 DNA polymerase III PolC; Validated; Region: polC; PRK00448 683837003746 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 683837003747 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 683837003748 generic binding surface II; other site 683837003749 generic binding surface I; other site 683837003750 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 683837003751 active site 683837003752 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 683837003753 active site 683837003754 catalytic site [active] 683837003755 substrate binding site [chemical binding]; other site 683837003756 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 683837003757 ribosome maturation protein RimP; Reviewed; Region: PRK00092 683837003758 Sm and related proteins; Region: Sm_like; cl00259 683837003759 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 683837003760 putative oligomer interface [polypeptide binding]; other site 683837003761 putative RNA binding site [nucleotide binding]; other site 683837003762 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 683837003763 NusA N-terminal domain; Region: NusA_N; pfam08529 683837003764 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 683837003765 RNA binding site [nucleotide binding]; other site 683837003766 homodimer interface [polypeptide binding]; other site 683837003767 NusA-like KH domain; Region: KH_5; pfam13184 683837003768 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 683837003769 G-X-X-G motif; other site 683837003770 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 683837003771 putative RNA binding cleft [nucleotide binding]; other site 683837003772 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 683837003773 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 683837003774 translation initiation factor IF-2; Region: IF-2; TIGR00487 683837003775 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 683837003776 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 683837003777 G1 box; other site 683837003778 putative GEF interaction site [polypeptide binding]; other site 683837003779 GTP/Mg2+ binding site [chemical binding]; other site 683837003780 Switch I region; other site 683837003781 G2 box; other site 683837003782 G3 box; other site 683837003783 Switch II region; other site 683837003784 G4 box; other site 683837003785 G5 box; other site 683837003786 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 683837003787 Translation-initiation factor 2; Region: IF-2; pfam11987 683837003788 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 683837003789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 683837003790 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 683837003791 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 683837003792 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 683837003793 RNA binding site [nucleotide binding]; other site 683837003794 active site 683837003795 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 683837003796 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 683837003797 active site 683837003798 Riboflavin kinase; Region: Flavokinase; smart00904 683837003799 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 683837003800 16S/18S rRNA binding site [nucleotide binding]; other site 683837003801 S13e-L30e interaction site [polypeptide binding]; other site 683837003802 25S rRNA binding site [nucleotide binding]; other site 683837003803 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 683837003804 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 683837003805 RNase E interface [polypeptide binding]; other site 683837003806 trimer interface [polypeptide binding]; other site 683837003807 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 683837003808 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 683837003809 RNase E interface [polypeptide binding]; other site 683837003810 trimer interface [polypeptide binding]; other site 683837003811 active site 683837003812 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 683837003813 putative nucleic acid binding region [nucleotide binding]; other site 683837003814 G-X-X-G motif; other site 683837003815 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 683837003816 RNA binding site [nucleotide binding]; other site 683837003817 domain interface; other site 683837003818 GTPase RsgA; Reviewed; Region: PRK01889 683837003819 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 683837003820 RNA binding site [nucleotide binding]; other site 683837003821 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 683837003822 GTPase/Zn-binding domain interface [polypeptide binding]; other site 683837003823 GTP/Mg2+ binding site [chemical binding]; other site 683837003824 G4 box; other site 683837003825 G5 box; other site 683837003826 G1 box; other site 683837003827 Switch I region; other site 683837003828 G2 box; other site 683837003829 G3 box; other site 683837003830 Switch II region; other site 683837003831 YceG-like family; Region: YceG; pfam02618 683837003832 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 683837003833 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 683837003834 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 683837003835 Rhomboid family; Region: Rhomboid; pfam01694 683837003836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 683837003837 TPR motif; other site 683837003838 binding surface 683837003839 TPR repeat; Region: TPR_11; pfam13414 683837003840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 683837003841 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 683837003842 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 683837003843 nucleotide binding site [chemical binding]; other site 683837003844 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 683837003845 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 683837003846 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 683837003847 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 683837003848 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 683837003849 Type II/IV secretion system protein; Region: T2SE; pfam00437 683837003850 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 683837003851 Walker A motif; other site 683837003852 ATP binding site [chemical binding]; other site 683837003853 Walker B motif; other site 683837003854 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 683837003855 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 683837003856 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 683837003857 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 683837003858 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 683837003859 tetramer interface [polypeptide binding]; other site 683837003860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837003861 catalytic residue [active] 683837003862 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 683837003863 tetramer interface [polypeptide binding]; other site 683837003864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837003865 catalytic residue [active] 683837003866 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 683837003867 active site residue [active] 683837003868 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 683837003869 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 683837003870 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 683837003871 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 683837003872 active site 683837003873 elongation factor P; Validated; Region: PRK00529 683837003874 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 683837003875 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 683837003876 RNA binding site [nucleotide binding]; other site 683837003877 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 683837003878 RNA binding site [nucleotide binding]; other site 683837003879 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 683837003880 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 683837003881 carboxyltransferase (CT) interaction site; other site 683837003882 biotinylation site [posttranslational modification]; other site 683837003883 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 683837003884 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 683837003885 ATP-grasp domain; Region: ATP-grasp_4; cl17255 683837003886 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 683837003887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 683837003888 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 683837003889 putative RNA binding site [nucleotide binding]; other site 683837003890 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 683837003891 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 683837003892 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 683837003893 homodimer interface [polypeptide binding]; other site 683837003894 NADP binding site [chemical binding]; other site 683837003895 substrate binding site [chemical binding]; other site 683837003896 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 683837003897 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 683837003898 generic binding surface II; other site 683837003899 generic binding surface I; other site 683837003900 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 683837003901 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 683837003902 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 683837003903 substrate binding pocket [chemical binding]; other site 683837003904 chain length determination region; other site 683837003905 substrate-Mg2+ binding site; other site 683837003906 catalytic residues [active] 683837003907 aspartate-rich region 1; other site 683837003908 active site lid residues [active] 683837003909 aspartate-rich region 2; other site 683837003910 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 683837003911 DNA-binding site [nucleotide binding]; DNA binding site 683837003912 RNA-binding motif; other site 683837003913 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 683837003914 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 683837003915 TPP-binding site; other site 683837003916 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 683837003917 PYR/PP interface [polypeptide binding]; other site 683837003918 dimer interface [polypeptide binding]; other site 683837003919 TPP binding site [chemical binding]; other site 683837003920 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 683837003921 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 683837003922 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 683837003923 RNA binding surface [nucleotide binding]; other site 683837003924 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 683837003925 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 683837003926 arginine repressor; Provisional; Region: PRK04280 683837003927 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 683837003928 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 683837003929 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 683837003930 Walker A/P-loop; other site 683837003931 ATP binding site [chemical binding]; other site 683837003932 Q-loop/lid; other site 683837003933 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 683837003934 ABC transporter signature motif; other site 683837003935 Walker B; other site 683837003936 D-loop; other site 683837003937 H-loop/switch region; other site 683837003938 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 683837003939 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 683837003940 nucleotide binding site [chemical binding]; other site 683837003941 Acetokinase family; Region: Acetate_kinase; cl17229 683837003942 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 683837003943 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 683837003944 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 683837003945 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 683837003946 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 683837003947 tetramer interface [polypeptide binding]; other site 683837003948 TPP-binding site [chemical binding]; other site 683837003949 heterodimer interface [polypeptide binding]; other site 683837003950 phosphorylation loop region [posttranslational modification] 683837003951 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 683837003952 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 683837003953 alpha subunit interface [polypeptide binding]; other site 683837003954 TPP binding site [chemical binding]; other site 683837003955 heterodimer interface [polypeptide binding]; other site 683837003956 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 683837003957 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 683837003958 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 683837003959 E3 interaction surface; other site 683837003960 lipoyl attachment site [posttranslational modification]; other site 683837003961 e3 binding domain; Region: E3_binding; pfam02817 683837003962 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 683837003963 peptidase T-like protein; Region: PepT-like; TIGR01883 683837003964 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 683837003965 metal binding site [ion binding]; metal-binding site 683837003966 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 683837003967 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 683837003968 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 683837003969 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 683837003970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837003971 active site 683837003972 phosphorylation site [posttranslational modification] 683837003973 intermolecular recognition site; other site 683837003974 dimerization interface [polypeptide binding]; other site 683837003975 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 683837003976 DNA binding site [nucleotide binding] 683837003977 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 683837003978 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 683837003979 dimerization interface [polypeptide binding]; other site 683837003980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 683837003981 dimer interface [polypeptide binding]; other site 683837003982 phosphorylation site [posttranslational modification] 683837003983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837003984 ATP binding site [chemical binding]; other site 683837003985 Mg2+ binding site [ion binding]; other site 683837003986 G-X-G motif; other site 683837003987 OxaA-like protein precursor; Validated; Region: PRK01622 683837003988 acylphosphatase; Provisional; Region: PRK14443 683837003989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 683837003990 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 683837003991 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 683837003992 homotetramer interface [polypeptide binding]; other site 683837003993 FMN binding site [chemical binding]; other site 683837003994 homodimer contacts [polypeptide binding]; other site 683837003995 putative active site [active] 683837003996 putative substrate binding site [chemical binding]; other site 683837003997 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 683837003998 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 683837003999 active site residue [active] 683837004000 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 683837004001 Uncharacterized conserved protein [Function unknown]; Region: COG1284 683837004002 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 683837004003 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 683837004004 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 683837004005 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 683837004006 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 683837004007 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 683837004008 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 683837004009 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 683837004010 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 683837004011 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 683837004012 ligand binding site [chemical binding]; other site 683837004013 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 683837004014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837004015 Walker A/P-loop; other site 683837004016 ATP binding site [chemical binding]; other site 683837004017 Q-loop/lid; other site 683837004018 ABC transporter signature motif; other site 683837004019 Walker B; other site 683837004020 D-loop; other site 683837004021 H-loop/switch region; other site 683837004022 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 683837004023 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 683837004024 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 683837004025 TM-ABC transporter signature motif; other site 683837004026 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 683837004027 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 683837004028 TM-ABC transporter signature motif; other site 683837004029 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 683837004030 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 683837004031 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 683837004032 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 683837004033 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 683837004034 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 683837004035 classical (c) SDRs; Region: SDR_c; cd05233 683837004036 NAD(P) binding site [chemical binding]; other site 683837004037 active site 683837004038 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 683837004039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837004040 non-specific DNA binding site [nucleotide binding]; other site 683837004041 salt bridge; other site 683837004042 sequence-specific DNA binding site [nucleotide binding]; other site 683837004043 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 683837004044 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 683837004045 competence damage-inducible protein A; Provisional; Region: PRK00549 683837004046 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 683837004047 putative MPT binding site; other site 683837004048 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 683837004049 recombinase A; Provisional; Region: recA; PRK09354 683837004050 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 683837004051 hexamer interface [polypeptide binding]; other site 683837004052 Walker A motif; other site 683837004053 ATP binding site [chemical binding]; other site 683837004054 Walker B motif; other site 683837004055 phosphodiesterase; Provisional; Region: PRK12704 683837004056 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 683837004057 Zn2+ binding site [ion binding]; other site 683837004058 Mg2+ binding site [ion binding]; other site 683837004059 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 683837004060 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 683837004061 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 683837004062 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 683837004063 putative active site [active] 683837004064 metal binding site [ion binding]; metal-binding site 683837004065 homodimer binding site [polypeptide binding]; other site 683837004066 Predicted membrane protein [Function unknown]; Region: COG4550 683837004067 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 683837004068 MutS domain I; Region: MutS_I; pfam01624 683837004069 MutS domain II; Region: MutS_II; pfam05188 683837004070 MutS domain III; Region: MutS_III; pfam05192 683837004071 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 683837004072 Walker A/P-loop; other site 683837004073 ATP binding site [chemical binding]; other site 683837004074 Q-loop/lid; other site 683837004075 ABC transporter signature motif; other site 683837004076 Walker B; other site 683837004077 D-loop; other site 683837004078 H-loop/switch region; other site 683837004079 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 683837004080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837004081 ATP binding site [chemical binding]; other site 683837004082 Mg2+ binding site [ion binding]; other site 683837004083 G-X-G motif; other site 683837004084 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 683837004085 ATP binding site [chemical binding]; other site 683837004086 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 683837004087 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 683837004088 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 683837004089 Pyruvate formate lyase 1; Region: PFL1; cd01678 683837004090 coenzyme A binding site [chemical binding]; other site 683837004091 active site 683837004092 catalytic residues [active] 683837004093 glycine loop; other site 683837004094 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 683837004095 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 683837004096 FeS/SAM binding site; other site 683837004097 Predicted transcriptional regulators [Transcription]; Region: COG1695 683837004098 Transcriptional regulator PadR-like family; Region: PadR; cl17335 683837004099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837004100 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837004101 putative substrate translocation pore; other site 683837004102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837004103 non-specific DNA binding site [nucleotide binding]; other site 683837004104 salt bridge; other site 683837004105 sequence-specific DNA binding site [nucleotide binding]; other site 683837004106 NifZ domain; Region: NifZ; pfam04319 683837004107 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 683837004108 putative acyltransferase; Provisional; Region: PRK05790 683837004109 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 683837004110 dimer interface [polypeptide binding]; other site 683837004111 active site 683837004112 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 683837004113 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 683837004114 dimer interface [polypeptide binding]; other site 683837004115 active site 683837004116 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 683837004117 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 683837004118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837004119 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 683837004120 Uncharacterized conserved protein [Function unknown]; Region: COG3379 683837004121 Domain of unknown function DUF20; Region: UPF0118; pfam01594 683837004122 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 683837004123 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 683837004124 FAD binding domain; Region: FAD_binding_4; pfam01565 683837004125 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 683837004126 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 683837004127 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 683837004128 Walker A/P-loop; other site 683837004129 ATP binding site [chemical binding]; other site 683837004130 Q-loop/lid; other site 683837004131 ABC transporter signature motif; other site 683837004132 Walker B; other site 683837004133 D-loop; other site 683837004134 H-loop/switch region; other site 683837004135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837004136 dimer interface [polypeptide binding]; other site 683837004137 conserved gate region; other site 683837004138 ABC-ATPase subunit interface; other site 683837004139 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 683837004140 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 683837004141 manganese transport protein MntH; Reviewed; Region: PRK00701 683837004142 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 683837004143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837004144 dimer interface [polypeptide binding]; other site 683837004145 conserved gate region; other site 683837004146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 683837004147 ABC-ATPase subunit interface; other site 683837004148 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 683837004149 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 683837004150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837004151 dimer interface [polypeptide binding]; other site 683837004152 conserved gate region; other site 683837004153 putative PBP binding loops; other site 683837004154 ABC-ATPase subunit interface; other site 683837004155 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 683837004156 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 683837004157 Walker A/P-loop; other site 683837004158 ATP binding site [chemical binding]; other site 683837004159 Q-loop/lid; other site 683837004160 ABC transporter signature motif; other site 683837004161 Walker B; other site 683837004162 D-loop; other site 683837004163 H-loop/switch region; other site 683837004164 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 683837004165 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491 683837004166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 683837004167 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 683837004168 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 683837004169 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 683837004170 ABC transporter; Region: ABC_tran_2; pfam12848 683837004171 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 683837004172 PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl17758 683837004173 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 683837004174 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 683837004175 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 683837004176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 683837004177 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 683837004178 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 683837004179 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 683837004180 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 683837004181 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 683837004182 dihydrodipicolinate synthase; Region: dapA; TIGR00674 683837004183 dimer interface [polypeptide binding]; other site 683837004184 active site 683837004185 catalytic residue [active] 683837004186 aspartate kinase I; Reviewed; Region: PRK08210 683837004187 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 683837004188 nucleotide binding site [chemical binding]; other site 683837004189 substrate binding site [chemical binding]; other site 683837004190 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 683837004191 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 683837004192 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 683837004193 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 683837004194 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 683837004195 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 683837004196 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 683837004197 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 683837004198 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 683837004199 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 683837004200 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 683837004201 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 683837004202 Predicted membrane protein [Function unknown]; Region: COG4392 683837004203 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 683837004204 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 683837004205 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 683837004206 metal binding site 2 [ion binding]; metal-binding site 683837004207 putative DNA binding helix; other site 683837004208 metal binding site 1 [ion binding]; metal-binding site 683837004209 dimer interface [polypeptide binding]; other site 683837004210 structural Zn2+ binding site [ion binding]; other site 683837004211 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 683837004212 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 683837004213 ABC-ATPase subunit interface; other site 683837004214 dimer interface [polypeptide binding]; other site 683837004215 putative PBP binding regions; other site 683837004216 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 683837004217 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 683837004218 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 683837004219 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 683837004220 DHHA2 domain; Region: DHHA2; pfam02833 683837004221 endonuclease IV; Provisional; Region: PRK01060 683837004222 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 683837004223 AP (apurinic/apyrimidinic) site pocket; other site 683837004224 DNA interaction; other site 683837004225 Metal-binding active site; metal-binding site 683837004226 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 683837004227 DEAD-like helicases superfamily; Region: DEXDc; smart00487 683837004228 ATP binding site [chemical binding]; other site 683837004229 Mg++ binding site [ion binding]; other site 683837004230 motif III; other site 683837004231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 683837004232 nucleotide binding region [chemical binding]; other site 683837004233 ATP-binding site [chemical binding]; other site 683837004234 Uncharacterized conserved protein [Function unknown]; Region: COG0327 683837004235 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 683837004236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 683837004237 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 683837004238 Uncharacterized conserved protein [Function unknown]; Region: COG0327 683837004239 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 683837004240 Family of unknown function (DUF633); Region: DUF633; pfam04816 683837004241 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 683837004242 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 683837004243 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 683837004244 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 683837004245 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 683837004246 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 683837004247 DNA binding residues [nucleotide binding] 683837004248 DNA primase; Validated; Region: dnaG; PRK05667 683837004249 CHC2 zinc finger; Region: zf-CHC2; pfam01807 683837004250 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 683837004251 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 683837004252 active site 683837004253 metal binding site [ion binding]; metal-binding site 683837004254 interdomain interaction site; other site 683837004255 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 683837004256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 683837004257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 683837004258 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 683837004259 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 683837004260 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 683837004261 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 683837004262 dimer interface [polypeptide binding]; other site 683837004263 motif 1; other site 683837004264 active site 683837004265 motif 2; other site 683837004266 motif 3; other site 683837004267 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 683837004268 Recombination protein O N terminal; Region: RecO_N; pfam11967 683837004269 Recombination protein O C terminal; Region: RecO_C; pfam02565 683837004270 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 683837004271 GTPase Era; Reviewed; Region: era; PRK00089 683837004272 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 683837004273 G1 box; other site 683837004274 GTP/Mg2+ binding site [chemical binding]; other site 683837004275 Switch I region; other site 683837004276 G2 box; other site 683837004277 Switch II region; other site 683837004278 G3 box; other site 683837004279 G4 box; other site 683837004280 G5 box; other site 683837004281 KH domain; Region: KH_2; pfam07650 683837004282 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 683837004283 active site 683837004284 catalytic motif [active] 683837004285 Zn binding site [ion binding]; other site 683837004286 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 683837004287 metal-binding heat shock protein; Provisional; Region: PRK00016 683837004288 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 683837004289 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 683837004290 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 683837004291 Zn2+ binding site [ion binding]; other site 683837004292 Mg2+ binding site [ion binding]; other site 683837004293 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 683837004294 PhoH-like protein; Region: PhoH; pfam02562 683837004295 Yqey-like protein; Region: YqeY; pfam09424 683837004296 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 683837004297 RNA methyltransferase, RsmE family; Region: TIGR00046 683837004298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 683837004299 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 683837004300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837004301 S-adenosylmethionine binding site [chemical binding]; other site 683837004302 chaperone protein DnaJ; Provisional; Region: PRK14280 683837004303 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 683837004304 HSP70 interaction site [polypeptide binding]; other site 683837004305 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 683837004306 substrate binding site [polypeptide binding]; other site 683837004307 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 683837004308 Zn binding sites [ion binding]; other site 683837004309 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 683837004310 dimer interface [polypeptide binding]; other site 683837004311 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 683837004312 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 683837004313 nucleotide binding site [chemical binding]; other site 683837004314 NEF interaction site [polypeptide binding]; other site 683837004315 SBD interface [polypeptide binding]; other site 683837004316 heat shock protein GrpE; Provisional; Region: PRK14140 683837004317 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 683837004318 dimer interface [polypeptide binding]; other site 683837004319 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 683837004320 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 683837004321 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 683837004322 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 683837004323 FeS/SAM binding site; other site 683837004324 HemN C-terminal domain; Region: HemN_C; pfam06969 683837004325 GTP-binding protein LepA; Provisional; Region: PRK05433 683837004326 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 683837004327 G1 box; other site 683837004328 putative GEF interaction site [polypeptide binding]; other site 683837004329 GTP/Mg2+ binding site [chemical binding]; other site 683837004330 Switch I region; other site 683837004331 G2 box; other site 683837004332 G3 box; other site 683837004333 Switch II region; other site 683837004334 G4 box; other site 683837004335 G5 box; other site 683837004336 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 683837004337 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 683837004338 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 683837004339 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 683837004340 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 683837004341 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 683837004342 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 683837004343 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 683837004344 Competence protein; Region: Competence; pfam03772 683837004345 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 683837004346 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 683837004347 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 683837004348 catalytic motif [active] 683837004349 Zn binding site [ion binding]; other site 683837004350 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 683837004351 SLBB domain; Region: SLBB; pfam10531 683837004352 Helix-hairpin-helix motif; Region: HHH; pfam00633 683837004353 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 683837004354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837004355 S-adenosylmethionine binding site [chemical binding]; other site 683837004356 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 683837004357 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 683837004358 Zn2+ binding site [ion binding]; other site 683837004359 Mg2+ binding site [ion binding]; other site 683837004360 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 683837004361 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 683837004362 active site 683837004363 (T/H)XGH motif; other site 683837004364 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 683837004365 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 683837004366 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 683837004367 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 683837004368 shikimate binding site; other site 683837004369 NAD(P) binding site [chemical binding]; other site 683837004370 GTPase YqeH; Provisional; Region: PRK13796 683837004371 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 683837004372 GTP/Mg2+ binding site [chemical binding]; other site 683837004373 G4 box; other site 683837004374 G5 box; other site 683837004375 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 683837004376 G1 box; other site 683837004377 G1 box; other site 683837004378 GTP/Mg2+ binding site [chemical binding]; other site 683837004379 G2 box; other site 683837004380 Switch I region; other site 683837004381 G2 box; other site 683837004382 Switch I region; other site 683837004383 G3 box; other site 683837004384 G3 box; other site 683837004385 Switch II region; other site 683837004386 Switch II region; other site 683837004387 G4 box; other site 683837004388 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 683837004389 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837004390 motif II; other site 683837004391 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 683837004392 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 683837004393 active site 683837004394 Zn binding site [ion binding]; other site 683837004395 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 683837004396 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 683837004397 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 683837004398 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 683837004399 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 683837004400 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 683837004401 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 683837004402 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 683837004403 Sugar specificity; other site 683837004404 Pyrimidine base specificity; other site 683837004405 ATP-binding site [chemical binding]; other site 683837004406 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 683837004407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837004408 S-adenosylmethionine binding site [chemical binding]; other site 683837004409 YceG-like family; Region: YceG; pfam02618 683837004410 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 683837004411 dimerization interface [polypeptide binding]; other site 683837004412 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 683837004413 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 683837004414 hypothetical protein; Provisional; Region: PRK13678 683837004415 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 683837004416 hypothetical protein; Provisional; Region: PRK05473 683837004417 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 683837004418 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 683837004419 motif 1; other site 683837004420 active site 683837004421 motif 2; other site 683837004422 motif 3; other site 683837004423 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 683837004424 DHHA1 domain; Region: DHHA1; pfam02272 683837004425 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 683837004426 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 683837004427 Walker A/P-loop; other site 683837004428 ATP binding site [chemical binding]; other site 683837004429 Q-loop/lid; other site 683837004430 ABC transporter signature motif; other site 683837004431 Walker B; other site 683837004432 D-loop; other site 683837004433 H-loop/switch region; other site 683837004434 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 683837004435 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 683837004436 FtsX-like permease family; Region: FtsX; pfam02687 683837004437 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 683837004438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837004439 active site 683837004440 phosphorylation site [posttranslational modification] 683837004441 intermolecular recognition site; other site 683837004442 dimerization interface [polypeptide binding]; other site 683837004443 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 683837004444 DNA binding site [nucleotide binding] 683837004445 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 683837004446 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 683837004447 dimerization interface [polypeptide binding]; other site 683837004448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 683837004449 dimer interface [polypeptide binding]; other site 683837004450 phosphorylation site [posttranslational modification] 683837004451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837004452 ATP binding site [chemical binding]; other site 683837004453 Mg2+ binding site [ion binding]; other site 683837004454 G-X-G motif; other site 683837004455 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 683837004456 AAA domain; Region: AAA_30; pfam13604 683837004457 Family description; Region: UvrD_C_2; pfam13538 683837004458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 683837004459 binding surface 683837004460 TPR motif; other site 683837004461 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 683837004462 TPR repeat; Region: TPR_11; pfam13414 683837004463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 683837004464 binding surface 683837004465 TPR motif; other site 683837004466 TPR repeat; Region: TPR_11; pfam13414 683837004467 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 683837004468 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 683837004469 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 683837004470 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 683837004471 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 683837004472 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 683837004473 catalytic residue [active] 683837004474 recombination factor protein RarA; Reviewed; Region: PRK13342 683837004475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837004476 Walker A motif; other site 683837004477 ATP binding site [chemical binding]; other site 683837004478 Walker B motif; other site 683837004479 arginine finger; other site 683837004480 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 683837004481 Predicted transcriptional regulator [Transcription]; Region: COG1959 683837004482 Transcriptional regulator; Region: Rrf2; pfam02082 683837004483 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 683837004484 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 683837004485 Nitrogen regulatory protein P-II; Region: P-II; smart00938 683837004486 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 683837004487 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 683837004488 dimer interface [polypeptide binding]; other site 683837004489 anticodon binding site; other site 683837004490 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 683837004491 homodimer interface [polypeptide binding]; other site 683837004492 motif 1; other site 683837004493 active site 683837004494 motif 2; other site 683837004495 GAD domain; Region: GAD; pfam02938 683837004496 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 683837004497 active site 683837004498 motif 3; other site 683837004499 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 683837004500 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 683837004501 dimer interface [polypeptide binding]; other site 683837004502 motif 1; other site 683837004503 active site 683837004504 motif 2; other site 683837004505 motif 3; other site 683837004506 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 683837004507 anticodon binding site; other site 683837004508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 683837004509 Bacterial SH3 domain; Region: SH3_3; pfam08239 683837004510 Bacterial SH3 domain; Region: SH3_3; pfam08239 683837004511 Bacterial SH3 domain homologues; Region: SH3b; smart00287 683837004512 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 683837004513 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 683837004514 active site 683837004515 metal binding site [ion binding]; metal-binding site 683837004516 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 683837004517 putative active site [active] 683837004518 dimerization interface [polypeptide binding]; other site 683837004519 putative tRNAtyr binding site [nucleotide binding]; other site 683837004520 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 683837004521 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 683837004522 Zn2+ binding site [ion binding]; other site 683837004523 Mg2+ binding site [ion binding]; other site 683837004524 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 683837004525 synthetase active site [active] 683837004526 NTP binding site [chemical binding]; other site 683837004527 metal binding site [ion binding]; metal-binding site 683837004528 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 683837004529 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 683837004530 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 683837004531 active site 683837004532 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 683837004533 DHH family; Region: DHH; pfam01368 683837004534 DHHA1 domain; Region: DHHA1; pfam02272 683837004535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 683837004536 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 683837004537 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 683837004538 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 683837004539 Protein export membrane protein; Region: SecD_SecF; cl14618 683837004540 Protein export membrane protein; Region: SecD_SecF; pfam02355 683837004541 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 683837004542 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 683837004543 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 683837004544 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 683837004545 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 683837004546 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 683837004547 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 683837004548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837004549 Walker A motif; other site 683837004550 ATP binding site [chemical binding]; other site 683837004551 Walker B motif; other site 683837004552 arginine finger; other site 683837004553 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 683837004554 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 683837004555 RuvA N terminal domain; Region: RuvA_N; pfam01330 683837004556 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 683837004557 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 683837004558 tetramer (dimer of dimers) interface [polypeptide binding]; other site 683837004559 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 683837004560 NAD binding site [chemical binding]; other site 683837004561 dimer interface [polypeptide binding]; other site 683837004562 substrate binding site [chemical binding]; other site 683837004563 hypothetical protein; Validated; Region: PRK00110 683837004564 prephenate dehydratase; Provisional; Region: PRK11898 683837004565 Prephenate dehydratase; Region: PDT; pfam00800 683837004566 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 683837004567 putative L-Phe binding site [chemical binding]; other site 683837004568 GTPase CgtA; Reviewed; Region: obgE; PRK12297 683837004569 GTP1/OBG; Region: GTP1_OBG; pfam01018 683837004570 Obg GTPase; Region: Obg; cd01898 683837004571 G1 box; other site 683837004572 GTP/Mg2+ binding site [chemical binding]; other site 683837004573 Switch I region; other site 683837004574 G2 box; other site 683837004575 G3 box; other site 683837004576 Switch II region; other site 683837004577 G4 box; other site 683837004578 G5 box; other site 683837004579 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 683837004580 glycerol kinase; Provisional; Region: glpK; PRK00047 683837004581 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 683837004582 N- and C-terminal domain interface [polypeptide binding]; other site 683837004583 active site 683837004584 MgATP binding site [chemical binding]; other site 683837004585 catalytic site [active] 683837004586 metal binding site [ion binding]; metal-binding site 683837004587 glycerol binding site [chemical binding]; other site 683837004588 homotetramer interface [polypeptide binding]; other site 683837004589 homodimer interface [polypeptide binding]; other site 683837004590 FBP binding site [chemical binding]; other site 683837004591 protein IIAGlc interface [polypeptide binding]; other site 683837004592 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 683837004593 amphipathic channel; other site 683837004594 Asn-Pro-Ala signature motifs; other site 683837004595 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 683837004596 hypothetical protein; Provisional; Region: PRK14553 683837004597 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 683837004598 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 683837004599 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 683837004600 homodimer interface [polypeptide binding]; other site 683837004601 oligonucleotide binding site [chemical binding]; other site 683837004602 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 683837004603 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 683837004604 Switch I; other site 683837004605 Switch II; other site 683837004606 septum formation inhibitor; Reviewed; Region: minC; PRK00513 683837004607 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 683837004608 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 683837004609 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 683837004610 rod shape-determining protein MreC; Region: MreC; pfam04085 683837004611 rod shape-determining protein MreB; Provisional; Region: PRK13927 683837004612 MreB and similar proteins; Region: MreB_like; cd10225 683837004613 nucleotide binding site [chemical binding]; other site 683837004614 Mg binding site [ion binding]; other site 683837004615 putative protofilament interaction site [polypeptide binding]; other site 683837004616 RodZ interaction site [polypeptide binding]; other site 683837004617 hypothetical protein; Reviewed; Region: PRK00024 683837004618 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 683837004619 MPN+ (JAMM) motif; other site 683837004620 Zinc-binding site [ion binding]; other site 683837004621 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 683837004622 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 683837004623 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 683837004624 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 683837004625 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 683837004626 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 683837004627 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 683837004628 active site 683837004629 HIGH motif; other site 683837004630 nucleotide binding site [chemical binding]; other site 683837004631 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 683837004632 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 683837004633 active site 683837004634 KMSKS motif; other site 683837004635 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 683837004636 tRNA binding surface [nucleotide binding]; other site 683837004637 anticodon binding site; other site 683837004638 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 683837004639 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 683837004640 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 683837004641 inhibitor-cofactor binding pocket; inhibition site 683837004642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837004643 catalytic residue [active] 683837004644 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 683837004645 dimer interface [polypeptide binding]; other site 683837004646 active site 683837004647 Schiff base residues; other site 683837004648 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 683837004649 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 683837004650 active site 683837004651 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 683837004652 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 683837004653 domain interfaces; other site 683837004654 active site 683837004655 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 683837004656 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 683837004657 tRNA; other site 683837004658 putative tRNA binding site [nucleotide binding]; other site 683837004659 putative NADP binding site [chemical binding]; other site 683837004660 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 683837004661 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 683837004662 G1 box; other site 683837004663 GTP/Mg2+ binding site [chemical binding]; other site 683837004664 Switch I region; other site 683837004665 G2 box; other site 683837004666 G3 box; other site 683837004667 Switch II region; other site 683837004668 G4 box; other site 683837004669 G5 box; other site 683837004670 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 683837004671 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 683837004672 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 683837004673 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 683837004674 active site 683837004675 dimer interface [polypeptide binding]; other site 683837004676 motif 1; other site 683837004677 motif 2; other site 683837004678 motif 3; other site 683837004679 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 683837004680 anticodon binding site; other site 683837004681 primosomal protein DnaI; Reviewed; Region: PRK08939 683837004682 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 683837004683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837004684 Walker A motif; other site 683837004685 ATP binding site [chemical binding]; other site 683837004686 Walker B motif; other site 683837004687 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 683837004688 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 683837004689 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 683837004690 ATP cone domain; Region: ATP-cone; pfam03477 683837004691 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 683837004692 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 683837004693 CoA-binding site [chemical binding]; other site 683837004694 ATP-binding [chemical binding]; other site 683837004695 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 683837004696 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 683837004697 DNA binding site [nucleotide binding] 683837004698 catalytic residue [active] 683837004699 H2TH interface [polypeptide binding]; other site 683837004700 putative catalytic residues [active] 683837004701 turnover-facilitating residue; other site 683837004702 intercalation triad [nucleotide binding]; other site 683837004703 8OG recognition residue [nucleotide binding]; other site 683837004704 putative reading head residues; other site 683837004705 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 683837004706 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 683837004707 DNA polymerase I; Provisional; Region: PRK05755 683837004708 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 683837004709 active site 683837004710 metal binding site 1 [ion binding]; metal-binding site 683837004711 putative 5' ssDNA interaction site; other site 683837004712 metal binding site 3; metal-binding site 683837004713 metal binding site 2 [ion binding]; metal-binding site 683837004714 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 683837004715 putative DNA binding site [nucleotide binding]; other site 683837004716 putative metal binding site [ion binding]; other site 683837004717 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 683837004718 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 683837004719 active site 683837004720 DNA binding site [nucleotide binding] 683837004721 catalytic site [active] 683837004722 isocitrate dehydrogenase; Reviewed; Region: PRK07006 683837004723 isocitrate dehydrogenase; Validated; Region: PRK07362 683837004724 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 683837004725 dimer interface [polypeptide binding]; other site 683837004726 Citrate synthase; Region: Citrate_synt; pfam00285 683837004727 active site 683837004728 citrylCoA binding site [chemical binding]; other site 683837004729 oxalacetate/citrate binding site [chemical binding]; other site 683837004730 coenzyme A binding site [chemical binding]; other site 683837004731 catalytic triad [active] 683837004732 Protein of unknown function (DUF441); Region: DUF441; pfam04284 683837004733 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 683837004734 pyruvate kinase; Provisional; Region: PRK06354 683837004735 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 683837004736 domain interfaces; other site 683837004737 active site 683837004738 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 683837004739 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 683837004740 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 683837004741 active site 683837004742 ADP/pyrophosphate binding site [chemical binding]; other site 683837004743 dimerization interface [polypeptide binding]; other site 683837004744 allosteric effector site; other site 683837004745 fructose-1,6-bisphosphate binding site; other site 683837004746 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 683837004747 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 683837004748 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 683837004749 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 683837004750 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 683837004751 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 683837004752 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 683837004753 active site 683837004754 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 683837004755 generic binding surface II; other site 683837004756 generic binding surface I; other site 683837004757 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 683837004758 DHH family; Region: DHH; pfam01368 683837004759 DHHA1 domain; Region: DHHA1; pfam02272 683837004760 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 683837004761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 683837004762 DNA-binding site [nucleotide binding]; DNA binding site 683837004763 DRTGG domain; Region: DRTGG; pfam07085 683837004764 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 683837004765 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 683837004766 active site 2 [active] 683837004767 active site 1 [active] 683837004768 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 683837004769 metal-dependent hydrolase; Provisional; Region: PRK00685 683837004770 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 683837004771 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 683837004772 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 683837004773 active site 683837004774 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 683837004775 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 683837004776 hexamer interface [polypeptide binding]; other site 683837004777 ligand binding site [chemical binding]; other site 683837004778 putative active site [active] 683837004779 NAD(P) binding site [chemical binding]; other site 683837004780 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 683837004781 Ligand Binding Site [chemical binding]; other site 683837004782 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 683837004783 propionate/acetate kinase; Provisional; Region: PRK12379 683837004784 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 683837004785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837004786 S-adenosylmethionine binding site [chemical binding]; other site 683837004787 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 683837004788 dimer interface [polypeptide binding]; other site 683837004789 catalytic triad [active] 683837004790 peroxidatic and resolving cysteines [active] 683837004791 RDD family; Region: RDD; pfam06271 683837004792 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 683837004793 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 683837004794 tandem repeat interface [polypeptide binding]; other site 683837004795 oligomer interface [polypeptide binding]; other site 683837004796 active site residues [active] 683837004797 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 683837004798 ATP-NAD kinase; Region: NAD_kinase; pfam01513 683837004799 ornithine carbamoyltransferase; Provisional; Region: PRK00779 683837004800 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 683837004801 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 683837004802 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 683837004803 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 683837004804 inhibitor-cofactor binding pocket; inhibition site 683837004805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837004806 catalytic residue [active] 683837004807 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 683837004808 nucleotide binding site [chemical binding]; other site 683837004809 N-acetyl-L-glutamate binding site [chemical binding]; other site 683837004810 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 683837004811 heterotetramer interface [polypeptide binding]; other site 683837004812 active site pocket [active] 683837004813 cleavage site 683837004814 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 683837004815 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 683837004816 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 683837004817 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 683837004818 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 683837004819 Ligand Binding Site [chemical binding]; other site 683837004820 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 683837004821 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 683837004822 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 683837004823 catalytic residue [active] 683837004824 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 683837004825 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 683837004826 GAF domain; Region: GAF_2; pfam13185 683837004827 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 683837004828 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 683837004829 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 683837004830 RNA binding surface [nucleotide binding]; other site 683837004831 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 683837004832 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 683837004833 active site 683837004834 HIGH motif; other site 683837004835 dimer interface [polypeptide binding]; other site 683837004836 KMSKS motif; other site 683837004837 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 683837004838 RNA binding surface [nucleotide binding]; other site 683837004839 catabolite control protein A; Region: ccpA; TIGR01481 683837004840 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 683837004841 DNA binding site [nucleotide binding] 683837004842 domain linker motif; other site 683837004843 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 683837004844 dimerization interface [polypeptide binding]; other site 683837004845 effector binding site; other site 683837004846 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 683837004847 Chorismate mutase type II; Region: CM_2; cl00693 683837004848 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 683837004849 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 683837004850 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 683837004851 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 683837004852 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 683837004853 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 683837004854 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 683837004855 dimer interface [polypeptide binding]; other site 683837004856 decamer (pentamer of dimers) interface [polypeptide binding]; other site 683837004857 catalytic triad [active] 683837004858 peroxidatic and resolving cysteines [active] 683837004859 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 683837004860 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 683837004861 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 683837004862 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 683837004863 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 683837004864 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 683837004865 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 683837004866 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 683837004867 putative tRNA-binding site [nucleotide binding]; other site 683837004868 hypothetical protein; Provisional; Region: PRK13668 683837004869 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 683837004870 catalytic residues [active] 683837004871 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 683837004872 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 683837004873 oligomer interface [polypeptide binding]; other site 683837004874 active site 683837004875 metal binding site [ion binding]; metal-binding site 683837004876 Predicted small secreted protein [Function unknown]; Region: COG5584 683837004877 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 683837004878 methionine cluster; other site 683837004879 active site 683837004880 phosphorylation site [posttranslational modification] 683837004881 metal binding site [ion binding]; metal-binding site 683837004882 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 683837004883 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 683837004884 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 683837004885 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 683837004886 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 683837004887 active site 683837004888 P-loop; other site 683837004889 phosphorylation site [posttranslational modification] 683837004890 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 683837004891 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 683837004892 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 683837004893 HTH domain; Region: HTH_11; pfam08279 683837004894 Mga helix-turn-helix domain; Region: Mga; pfam05043 683837004895 PRD domain; Region: PRD; pfam00874 683837004896 PRD domain; Region: PRD; pfam00874 683837004897 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 683837004898 active site 683837004899 P-loop; other site 683837004900 phosphorylation site [posttranslational modification] 683837004901 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 683837004902 active site 683837004903 phosphorylation site [posttranslational modification] 683837004904 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 683837004905 putative homodimer interface [polypeptide binding]; other site 683837004906 putative homotetramer interface [polypeptide binding]; other site 683837004907 putative allosteric switch controlling residues; other site 683837004908 putative metal binding site [ion binding]; other site 683837004909 putative homodimer-homodimer interface [polypeptide binding]; other site 683837004910 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 683837004911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837004912 S-adenosylmethionine binding site [chemical binding]; other site 683837004913 Phosphotransferase enzyme family; Region: APH; pfam01636 683837004914 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 683837004915 active site 683837004916 ATP binding site [chemical binding]; other site 683837004917 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 683837004918 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 683837004919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837004920 putative substrate translocation pore; other site 683837004921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 683837004922 putative Zn2+ binding site [ion binding]; other site 683837004923 putative DNA binding site [nucleotide binding]; other site 683837004924 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 683837004925 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 683837004926 homodimer interface [polypeptide binding]; other site 683837004927 substrate-cofactor binding pocket; other site 683837004928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837004929 catalytic residue [active] 683837004930 dipeptidase PepV; Reviewed; Region: PRK07318 683837004931 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 683837004932 active site 683837004933 metal binding site [ion binding]; metal-binding site 683837004934 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 683837004935 nudix motif; other site 683837004936 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 683837004937 putative substrate binding site [chemical binding]; other site 683837004938 putative ATP binding site [chemical binding]; other site 683837004939 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 683837004940 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 683837004941 active site 683837004942 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 683837004943 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 683837004944 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 683837004945 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 683837004946 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 683837004947 substrate binding site [chemical binding]; other site 683837004948 active site 683837004949 catalytic residues [active] 683837004950 heterodimer interface [polypeptide binding]; other site 683837004951 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 683837004952 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 683837004953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837004954 catalytic residue [active] 683837004955 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 683837004956 active site 683837004957 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 683837004958 active site 683837004959 ribulose/triose binding site [chemical binding]; other site 683837004960 phosphate binding site [ion binding]; other site 683837004961 substrate (anthranilate) binding pocket [chemical binding]; other site 683837004962 product (indole) binding pocket [chemical binding]; other site 683837004963 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 683837004964 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 683837004965 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 683837004966 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 683837004967 Glutamine amidotransferase class-I; Region: GATase; pfam00117 683837004968 glutamine binding [chemical binding]; other site 683837004969 catalytic triad [active] 683837004970 anthranilate synthase component I; Provisional; Region: PRK13570 683837004971 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 683837004972 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 683837004973 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 683837004974 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 683837004975 putative catalytic cysteine [active] 683837004976 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 683837004977 putative active site [active] 683837004978 metal binding site [ion binding]; metal-binding site 683837004979 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 683837004980 dimer interface [polypeptide binding]; other site 683837004981 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 683837004982 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 683837004983 Walker A/P-loop; other site 683837004984 ATP binding site [chemical binding]; other site 683837004985 Q-loop/lid; other site 683837004986 ABC transporter signature motif; other site 683837004987 Walker B; other site 683837004988 D-loop; other site 683837004989 H-loop/switch region; other site 683837004990 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 683837004991 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 683837004992 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 683837004993 putative dimer interface [polypeptide binding]; other site 683837004994 catalytic triad [active] 683837004995 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 683837004996 aconitate hydratase; Validated; Region: PRK09277 683837004997 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 683837004998 substrate binding site [chemical binding]; other site 683837004999 ligand binding site [chemical binding]; other site 683837005000 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 683837005001 substrate binding site [chemical binding]; other site 683837005002 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 683837005003 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 683837005004 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 683837005005 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 683837005006 ATP binding site [chemical binding]; other site 683837005007 putative Mg++ binding site [ion binding]; other site 683837005008 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 683837005009 nucleotide binding region [chemical binding]; other site 683837005010 ATP-binding site [chemical binding]; other site 683837005011 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 683837005012 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 683837005013 Walker A/P-loop; other site 683837005014 ATP binding site [chemical binding]; other site 683837005015 Q-loop/lid; other site 683837005016 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 683837005017 ABC transporter signature motif; other site 683837005018 Walker B; other site 683837005019 D-loop; other site 683837005020 H-loop/switch region; other site 683837005021 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 683837005022 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 683837005023 active site 683837005024 metal binding site [ion binding]; metal-binding site 683837005025 DNA binding site [nucleotide binding] 683837005026 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 683837005027 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 683837005028 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 683837005029 putative acyl-acceptor binding pocket; other site 683837005030 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 683837005031 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 683837005032 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 683837005033 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 683837005034 Walker A/P-loop; other site 683837005035 ATP binding site [chemical binding]; other site 683837005036 Q-loop/lid; other site 683837005037 ABC transporter signature motif; other site 683837005038 Walker B; other site 683837005039 D-loop; other site 683837005040 H-loop/switch region; other site 683837005041 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 683837005042 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 683837005043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837005044 Walker A/P-loop; other site 683837005045 ATP binding site [chemical binding]; other site 683837005046 Q-loop/lid; other site 683837005047 ABC transporter signature motif; other site 683837005048 Walker B; other site 683837005049 D-loop; other site 683837005050 H-loop/switch region; other site 683837005051 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 683837005052 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 683837005053 active site 683837005054 active site 683837005055 elongation factor Ts; Provisional; Region: tsf; PRK09377 683837005056 UBA/TS-N domain; Region: UBA; pfam00627 683837005057 Elongation factor TS; Region: EF_TS; pfam00889 683837005058 Elongation factor TS; Region: EF_TS; pfam00889 683837005059 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 683837005060 rRNA interaction site [nucleotide binding]; other site 683837005061 S8 interaction site; other site 683837005062 putative laminin-1 binding site; other site 683837005063 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 683837005064 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 683837005065 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 683837005066 active site turn [active] 683837005067 phosphorylation site [posttranslational modification] 683837005068 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 683837005069 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 683837005070 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 683837005071 putative active site [active] 683837005072 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 683837005073 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 683837005074 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 683837005075 putative active site [active] 683837005076 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 683837005077 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 683837005078 HIGH motif; other site 683837005079 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 683837005080 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 683837005081 active site 683837005082 KMSKS motif; other site 683837005083 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 683837005084 tRNA binding surface [nucleotide binding]; other site 683837005085 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 683837005086 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 683837005087 FeS/SAM binding site; other site 683837005088 Methyltransferase domain; Region: Methyltransf_31; pfam13847 683837005089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837005090 S-adenosylmethionine binding site [chemical binding]; other site 683837005091 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 683837005092 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 683837005093 active site 683837005094 dimer interface [polypeptide binding]; other site 683837005095 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 683837005096 Ligand Binding Site [chemical binding]; other site 683837005097 Molecular Tunnel; other site 683837005098 S-adenosylmethionine synthetase; Validated; Region: PRK05250 683837005099 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 683837005100 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 683837005101 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 683837005102 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 683837005103 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 683837005104 active site 683837005105 metal binding site [ion binding]; metal-binding site 683837005106 Phage holin; Region: Phage_holin_5; pfam06946 683837005107 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 683837005108 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 683837005109 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 683837005110 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 683837005111 Phage tail protein; Region: Sipho_tail; cl17486 683837005112 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 683837005113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837005114 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 683837005115 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 683837005116 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 683837005117 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 683837005118 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 683837005119 Phage terminase large subunit; Region: Terminase_3; cl12054 683837005120 Terminase-like family; Region: Terminase_6; pfam03237 683837005121 Uncharacterized conserved protein [Function unknown]; Region: COG5484 683837005122 Phage terminase small subunit; Region: Phage_terminase; pfam10668 683837005123 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 683837005124 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 683837005125 active site 683837005126 DNA binding site [nucleotide binding] 683837005127 Int/Topo IB signature motif; other site 683837005128 positive control sigma-like factor; Validated; Region: PRK06930 683837005129 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 683837005130 DNA binding residues [nucleotide binding] 683837005131 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 683837005132 Helix-turn-helix domain; Region: HTH_36; pfam13730 683837005133 YjzC-like protein; Region: YjzC; pfam14168 683837005134 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 683837005135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837005136 non-specific DNA binding site [nucleotide binding]; other site 683837005137 salt bridge; other site 683837005138 sequence-specific DNA binding site [nucleotide binding]; other site 683837005139 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 683837005140 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 683837005141 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 683837005142 active site 683837005143 DNA binding site [nucleotide binding] 683837005144 Int/Topo IB signature motif; other site 683837005145 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 683837005146 tetramer (dimer of dimers) interface [polypeptide binding]; other site 683837005147 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 683837005148 NAD binding site [chemical binding]; other site 683837005149 dimer interface [polypeptide binding]; other site 683837005150 substrate binding site [chemical binding]; other site 683837005151 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 683837005152 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 683837005153 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 683837005154 nudix motif; other site 683837005155 Haemolytic domain; Region: Haemolytic; pfam01809 683837005156 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 683837005157 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 683837005158 metal binding site [ion binding]; metal-binding site 683837005159 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 683837005160 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 683837005161 acyl-activating enzyme (AAE) consensus motif; other site 683837005162 putative AMP binding site [chemical binding]; other site 683837005163 putative active site [active] 683837005164 putative CoA binding site [chemical binding]; other site 683837005165 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 683837005166 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 683837005167 substrate binding site [chemical binding]; other site 683837005168 oxyanion hole (OAH) forming residues; other site 683837005169 trimer interface [polypeptide binding]; other site 683837005170 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 683837005171 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 683837005172 TAP-like protein; Region: Abhydrolase_4; pfam08386 683837005173 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 683837005174 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 683837005175 dimer interface [polypeptide binding]; other site 683837005176 tetramer interface [polypeptide binding]; other site 683837005177 PYR/PP interface [polypeptide binding]; other site 683837005178 TPP binding site [chemical binding]; other site 683837005179 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 683837005180 TPP-binding site; other site 683837005181 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 683837005182 chorismate binding enzyme; Region: Chorismate_bind; cl10555 683837005183 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 683837005184 UbiA prenyltransferase family; Region: UbiA; pfam01040 683837005185 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 683837005186 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 683837005187 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 683837005188 FAD binding site [chemical binding]; other site 683837005189 cystathionine beta-lyase; Provisional; Region: PRK08064 683837005190 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 683837005191 homodimer interface [polypeptide binding]; other site 683837005192 substrate-cofactor binding pocket; other site 683837005193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837005194 catalytic residue [active] 683837005195 cystathionine gamma-synthase; Reviewed; Region: PRK08247 683837005196 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 683837005197 homodimer interface [polypeptide binding]; other site 683837005198 substrate-cofactor binding pocket; other site 683837005199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837005200 catalytic residue [active] 683837005201 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 683837005202 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 683837005203 THF binding site; other site 683837005204 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 683837005205 substrate binding site [chemical binding]; other site 683837005206 THF binding site; other site 683837005207 zinc-binding site [ion binding]; other site 683837005208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837005209 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837005210 putative substrate translocation pore; other site 683837005211 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 683837005212 metal binding site 2 [ion binding]; metal-binding site 683837005213 putative DNA binding helix; other site 683837005214 metal binding site 1 [ion binding]; metal-binding site 683837005215 dimer interface [polypeptide binding]; other site 683837005216 structural Zn2+ binding site [ion binding]; other site 683837005217 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 683837005218 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 683837005219 NAD binding site [chemical binding]; other site 683837005220 ligand binding site [chemical binding]; other site 683837005221 catalytic site [active] 683837005222 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 683837005223 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 683837005224 inhibitor-cofactor binding pocket; inhibition site 683837005225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837005226 catalytic residue [active] 683837005227 Predicted membrane protein [Function unknown]; Region: COG4129 683837005228 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 683837005229 hypothetical protein; Provisional; Region: PRK13662 683837005230 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 683837005231 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 683837005232 putative NAD(P) binding site [chemical binding]; other site 683837005233 active site 683837005234 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 683837005235 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 683837005236 minor groove reading motif; other site 683837005237 helix-hairpin-helix signature motif; other site 683837005238 substrate binding pocket [chemical binding]; other site 683837005239 active site 683837005240 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 683837005241 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 683837005242 DNA binding and oxoG recognition site [nucleotide binding] 683837005243 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 683837005244 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 683837005245 trimer interface [polypeptide binding]; other site 683837005246 active site 683837005247 WVELL protein; Region: WVELL; pfam14043 683837005248 recombination regulator RecX; Provisional; Region: recX; PRK14135 683837005249 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 683837005250 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 683837005251 putative NAD(P) binding site [chemical binding]; other site 683837005252 putative active site [active] 683837005253 Predicted integral membrane protein [Function unknown]; Region: COG0392 683837005254 Uncharacterized conserved protein [Function unknown]; Region: COG2898 683837005255 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 683837005256 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 683837005257 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 683837005258 Cation efflux family; Region: Cation_efflux; pfam01545 683837005259 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 683837005260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 683837005261 PAS fold; Region: PAS_4; pfam08448 683837005262 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 683837005263 putative active site [active] 683837005264 heme pocket [chemical binding]; other site 683837005265 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 683837005266 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 683837005267 dimer interface [polypeptide binding]; other site 683837005268 putative CheW interface [polypeptide binding]; other site 683837005269 TRAM domain; Region: TRAM; cl01282 683837005270 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 683837005271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837005272 S-adenosylmethionine binding site [chemical binding]; other site 683837005273 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 683837005274 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 683837005275 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 683837005276 Substrate-binding site [chemical binding]; other site 683837005277 Substrate specificity [chemical binding]; other site 683837005278 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 683837005279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 683837005280 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 683837005281 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 683837005282 active site 683837005283 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 683837005284 flavodoxin, short chain; Region: flav_short; TIGR01753 683837005285 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 683837005286 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 683837005287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837005288 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837005289 putative substrate translocation pore; other site 683837005290 MreB and similar proteins; Region: MreB_like; cd10225 683837005291 rod shape-determining protein MreB; Provisional; Region: PRK13930 683837005292 nucleotide binding site [chemical binding]; other site 683837005293 Mg binding site [ion binding]; other site 683837005294 putative protofilament interaction site [polypeptide binding]; other site 683837005295 RodZ interaction site [polypeptide binding]; other site 683837005296 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 683837005297 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 683837005298 ligand binding site [chemical binding]; other site 683837005299 flexible hinge region; other site 683837005300 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 683837005301 non-specific DNA interactions [nucleotide binding]; other site 683837005302 DNA binding site [nucleotide binding] 683837005303 sequence specific DNA binding site [nucleotide binding]; other site 683837005304 putative cAMP binding site [chemical binding]; other site 683837005305 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 683837005306 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 683837005307 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 683837005308 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 683837005309 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 683837005310 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 683837005311 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 683837005312 MarR family; Region: MarR; pfam01047 683837005313 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 683837005314 Uncharacterized conserved protein [Function unknown]; Region: COG3589 683837005315 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 683837005316 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 683837005317 methionine cluster; other site 683837005318 active site 683837005319 phosphorylation site [posttranslational modification] 683837005320 metal binding site [ion binding]; metal-binding site 683837005321 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 683837005322 active site 683837005323 P-loop; other site 683837005324 phosphorylation site [posttranslational modification] 683837005325 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 683837005326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837005327 Walker A motif; other site 683837005328 ATP binding site [chemical binding]; other site 683837005329 Walker B motif; other site 683837005330 arginine finger; other site 683837005331 Transcriptional antiterminator [Transcription]; Region: COG3933 683837005332 PRD domain; Region: PRD; pfam00874 683837005333 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 683837005334 active pocket/dimerization site; other site 683837005335 active site 683837005336 phosphorylation site [posttranslational modification] 683837005337 PRD domain; Region: PRD; pfam00874 683837005338 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 683837005339 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 683837005340 ATP binding site [chemical binding]; other site 683837005341 putative Mg++ binding site [ion binding]; other site 683837005342 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 683837005343 nucleotide binding region [chemical binding]; other site 683837005344 ATP-binding site [chemical binding]; other site 683837005345 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 683837005346 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 683837005347 Walker A/P-loop; other site 683837005348 ATP binding site [chemical binding]; other site 683837005349 Q-loop/lid; other site 683837005350 ABC transporter signature motif; other site 683837005351 Walker B; other site 683837005352 D-loop; other site 683837005353 H-loop/switch region; other site 683837005354 Predicted transcriptional regulators [Transcription]; Region: COG1725 683837005355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837005356 DNA-binding site [nucleotide binding]; DNA binding site 683837005357 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 683837005358 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 683837005359 Transcriptional regulators [Transcription]; Region: PurR; COG1609 683837005360 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 683837005361 DNA binding site [nucleotide binding] 683837005362 domain linker motif; other site 683837005363 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 683837005364 dimerization interface [polypeptide binding]; other site 683837005365 ligand binding site [chemical binding]; other site 683837005366 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 683837005367 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 683837005368 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 683837005369 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 683837005370 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 683837005371 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 683837005372 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 683837005373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837005374 dimer interface [polypeptide binding]; other site 683837005375 conserved gate region; other site 683837005376 putative PBP binding loops; other site 683837005377 ABC-ATPase subunit interface; other site 683837005378 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 683837005379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837005380 dimer interface [polypeptide binding]; other site 683837005381 conserved gate region; other site 683837005382 putative PBP binding loops; other site 683837005383 ABC-ATPase subunit interface; other site 683837005384 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 683837005385 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 683837005386 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 683837005387 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 683837005388 active site 683837005389 dimer interface [polypeptide binding]; other site 683837005390 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 683837005391 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 683837005392 active site 683837005393 FMN binding site [chemical binding]; other site 683837005394 substrate binding site [chemical binding]; other site 683837005395 3Fe-4S cluster binding site [ion binding]; other site 683837005396 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 683837005397 domain interface; other site 683837005398 Transcriptional regulator [Transcription]; Region: LysR; COG0583 683837005399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 683837005400 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 683837005401 putative dimerization interface [polypeptide binding]; other site 683837005402 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 683837005403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 683837005404 Coenzyme A binding pocket [chemical binding]; other site 683837005405 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 683837005406 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 683837005407 putative active site [active] 683837005408 metal binding site [ion binding]; metal-binding site 683837005409 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 683837005410 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 683837005411 substrate binding pocket [chemical binding]; other site 683837005412 membrane-bound complex binding site; other site 683837005413 hinge residues; other site 683837005414 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 683837005415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837005416 Walker A/P-loop; other site 683837005417 ATP binding site [chemical binding]; other site 683837005418 Q-loop/lid; other site 683837005419 ABC transporter signature motif; other site 683837005420 Walker B; other site 683837005421 D-loop; other site 683837005422 H-loop/switch region; other site 683837005423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837005424 dimer interface [polypeptide binding]; other site 683837005425 conserved gate region; other site 683837005426 putative PBP binding loops; other site 683837005427 ABC-ATPase subunit interface; other site 683837005428 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 683837005429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 683837005430 dimer interface [polypeptide binding]; other site 683837005431 phosphorylation site [posttranslational modification] 683837005432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837005433 ATP binding site [chemical binding]; other site 683837005434 Mg2+ binding site [ion binding]; other site 683837005435 G-X-G motif; other site 683837005436 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 683837005437 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 683837005438 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 683837005439 active site 683837005440 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 683837005441 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 683837005442 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 683837005443 putative NAD(P) binding site [chemical binding]; other site 683837005444 active site 683837005445 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 683837005446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837005447 active site 683837005448 phosphorylation site [posttranslational modification] 683837005449 intermolecular recognition site; other site 683837005450 dimerization interface [polypeptide binding]; other site 683837005451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 683837005452 DNA binding site [nucleotide binding] 683837005453 FtsX-like permease family; Region: FtsX; pfam02687 683837005454 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 683837005455 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 683837005456 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 683837005457 Walker A/P-loop; other site 683837005458 ATP binding site [chemical binding]; other site 683837005459 Q-loop/lid; other site 683837005460 ABC transporter signature motif; other site 683837005461 Walker B; other site 683837005462 D-loop; other site 683837005463 H-loop/switch region; other site 683837005464 Predicted amidohydrolase [General function prediction only]; Region: COG0388 683837005465 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 683837005466 active site 683837005467 catalytic triad [active] 683837005468 dimer interface [polypeptide binding]; other site 683837005469 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 683837005470 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 683837005471 ADP binding site [chemical binding]; other site 683837005472 magnesium binding site [ion binding]; other site 683837005473 putative shikimate binding site; other site 683837005474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 683837005475 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 683837005476 TRAM domain; Region: TRAM; pfam01938 683837005477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837005478 S-adenosylmethionine binding site [chemical binding]; other site 683837005479 putative lipid kinase; Reviewed; Region: PRK13337 683837005480 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 683837005481 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 683837005482 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 683837005483 GatB domain; Region: GatB_Yqey; pfam02637 683837005484 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 683837005485 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 683837005486 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 683837005487 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 683837005488 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 683837005489 putative dimer interface [polypeptide binding]; other site 683837005490 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 683837005491 putative dimer interface [polypeptide binding]; other site 683837005492 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 683837005493 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 683837005494 nucleotide binding pocket [chemical binding]; other site 683837005495 K-X-D-G motif; other site 683837005496 catalytic site [active] 683837005497 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 683837005498 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 683837005499 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 683837005500 Dimer interface [polypeptide binding]; other site 683837005501 BRCT sequence motif; other site 683837005502 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 683837005503 Part of AAA domain; Region: AAA_19; pfam13245 683837005504 Family description; Region: UvrD_C_2; pfam13538 683837005505 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 683837005506 substrate binding site [chemical binding]; other site 683837005507 putative active site [active] 683837005508 dimer interface [polypeptide binding]; other site 683837005509 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 683837005510 Na2 binding site [ion binding]; other site 683837005511 putative substrate binding site 1 [chemical binding]; other site 683837005512 Na binding site 1 [ion binding]; other site 683837005513 putative substrate binding site 2 [chemical binding]; other site 683837005514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 683837005515 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 683837005516 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 683837005517 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 683837005518 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 683837005519 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 683837005520 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 683837005521 purine monophosphate binding site [chemical binding]; other site 683837005522 dimer interface [polypeptide binding]; other site 683837005523 putative catalytic residues [active] 683837005524 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 683837005525 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 683837005526 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 683837005527 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 683837005528 active site 683837005529 substrate binding site [chemical binding]; other site 683837005530 cosubstrate binding site; other site 683837005531 catalytic site [active] 683837005532 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 683837005533 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 683837005534 dimerization interface [polypeptide binding]; other site 683837005535 putative ATP binding site [chemical binding]; other site 683837005536 amidophosphoribosyltransferase; Provisional; Region: PRK06781 683837005537 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 683837005538 active site 683837005539 tetramer interface [polypeptide binding]; other site 683837005540 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 683837005541 active site 683837005542 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 683837005543 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 683837005544 dimerization interface [polypeptide binding]; other site 683837005545 ATP binding site [chemical binding]; other site 683837005546 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 683837005547 dimerization interface [polypeptide binding]; other site 683837005548 ATP binding site [chemical binding]; other site 683837005549 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 683837005550 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 683837005551 putative active site [active] 683837005552 catalytic triad [active] 683837005553 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 683837005554 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 683837005555 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 683837005556 ATP binding site [chemical binding]; other site 683837005557 active site 683837005558 substrate binding site [chemical binding]; other site 683837005559 adenylosuccinate lyase; Provisional; Region: PRK07492 683837005560 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 683837005561 tetramer interface [polypeptide binding]; other site 683837005562 active site 683837005563 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 683837005564 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 683837005565 NAD binding site [chemical binding]; other site 683837005566 ATP-grasp domain; Region: ATP-grasp; pfam02222 683837005567 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 683837005568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 683837005569 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 683837005570 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 683837005571 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 683837005572 Zn2+ binding site [ion binding]; other site 683837005573 Mg2+ binding site [ion binding]; other site 683837005574 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 683837005575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837005576 Walker A/P-loop; other site 683837005577 ATP binding site [chemical binding]; other site 683837005578 Q-loop/lid; other site 683837005579 ABC transporter signature motif; other site 683837005580 Walker B; other site 683837005581 D-loop; other site 683837005582 H-loop/switch region; other site 683837005583 peptidase T; Region: peptidase-T; TIGR01882 683837005584 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 683837005585 metal binding site [ion binding]; metal-binding site 683837005586 dimer interface [polypeptide binding]; other site 683837005587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 683837005588 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 683837005589 active site 683837005590 putative catalytic site [active] 683837005591 DNA binding site [nucleotide binding] 683837005592 putative phosphate binding site [ion binding]; other site 683837005593 metal binding site A [ion binding]; metal-binding site 683837005594 AP binding site [nucleotide binding]; other site 683837005595 metal binding site B [ion binding]; metal-binding site 683837005596 Transcriptional regulator [Transcription]; Region: LysR; COG0583 683837005597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 683837005598 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 683837005599 dimerization interface [polypeptide binding]; other site 683837005600 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 683837005601 active site 1 [active] 683837005602 dimer interface [polypeptide binding]; other site 683837005603 hexamer interface [polypeptide binding]; other site 683837005604 active site 2 [active] 683837005605 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 683837005606 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 683837005607 23S rRNA binding site [nucleotide binding]; other site 683837005608 L21 binding site [polypeptide binding]; other site 683837005609 L13 binding site [polypeptide binding]; other site 683837005610 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 683837005611 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 683837005612 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 683837005613 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 683837005614 Protein of unknown function DUF45; Region: DUF45; pfam01863 683837005615 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 683837005616 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 683837005617 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 683837005618 ATP binding site [chemical binding]; other site 683837005619 putative Mg++ binding site [ion binding]; other site 683837005620 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 683837005621 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 683837005622 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 683837005623 HsdM N-terminal domain; Region: HsdM_N; pfam12161 683837005624 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 683837005625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837005626 S-adenosylmethionine binding site [chemical binding]; other site 683837005627 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 683837005628 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 683837005631 Bacterial epsilon antitoxin; Region: Epsilon_antitox; pfam08998 683837005632 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 683837005633 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 683837005634 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 683837005635 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 683837005636 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 683837005637 RimM N-terminal domain; Region: RimM; pfam01782 683837005638 PRC-barrel domain; Region: PRC; pfam05239 683837005639 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 683837005640 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 683837005641 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 683837005642 catalytic triad [active] 683837005643 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 683837005644 KH domain; Region: KH_4; pfam13083 683837005645 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 683837005646 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 683837005647 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 683837005648 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 683837005649 signal recognition particle protein; Provisional; Region: PRK10867 683837005650 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 683837005651 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 683837005652 P loop; other site 683837005653 GTP binding site [chemical binding]; other site 683837005654 Signal peptide binding domain; Region: SRP_SPB; pfam02978 683837005655 putative DNA-binding protein; Validated; Region: PRK00118 683837005656 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 683837005657 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 683837005658 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 683837005659 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 683837005660 P loop; other site 683837005661 GTP binding site [chemical binding]; other site 683837005662 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 683837005663 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 683837005664 Walker A/P-loop; other site 683837005665 ATP binding site [chemical binding]; other site 683837005666 Q-loop/lid; other site 683837005667 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 683837005668 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 683837005669 linker region; other site 683837005670 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 683837005671 ABC transporter signature motif; other site 683837005672 Walker B; other site 683837005673 D-loop; other site 683837005674 H-loop/switch region; other site 683837005675 ribonuclease III; Reviewed; Region: rnc; PRK00102 683837005676 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 683837005677 dimerization interface [polypeptide binding]; other site 683837005678 active site 683837005679 metal binding site [ion binding]; metal-binding site 683837005680 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 683837005681 dsRNA binding site [nucleotide binding]; other site 683837005682 acyl carrier protein; Provisional; Region: acpP; PRK00982 683837005683 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 683837005684 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 683837005685 NAD(P) binding site [chemical binding]; other site 683837005686 homotetramer interface [polypeptide binding]; other site 683837005687 homodimer interface [polypeptide binding]; other site 683837005688 active site 683837005689 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 683837005690 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 683837005691 putative phosphate acyltransferase; Provisional; Region: PRK05331 683837005692 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 683837005693 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 683837005694 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 683837005695 Y-family of DNA polymerases; Region: PolY; cl12025 683837005696 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 683837005697 generic binding surface II; other site 683837005698 ssDNA binding site; other site 683837005699 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 683837005700 ATP binding site [chemical binding]; other site 683837005701 putative Mg++ binding site [ion binding]; other site 683837005702 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 683837005703 nucleotide binding region [chemical binding]; other site 683837005704 ATP-binding site [chemical binding]; other site 683837005705 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 683837005706 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 683837005707 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 683837005708 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 683837005709 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 683837005710 putative L-serine binding site [chemical binding]; other site 683837005711 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 683837005712 DAK2 domain; Region: Dak2; pfam02734 683837005713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 683837005714 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 683837005715 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 683837005716 Thiamine pyrophosphokinase; Region: TPK; cd07995 683837005717 active site 683837005718 dimerization interface [polypeptide binding]; other site 683837005719 thiamine binding site [chemical binding]; other site 683837005720 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 683837005721 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 683837005722 substrate binding site [chemical binding]; other site 683837005723 hexamer interface [polypeptide binding]; other site 683837005724 metal binding site [ion binding]; metal-binding site 683837005725 GTPase RsgA; Reviewed; Region: PRK00098 683837005726 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 683837005727 RNA binding site [nucleotide binding]; other site 683837005728 homodimer interface [polypeptide binding]; other site 683837005729 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 683837005730 GTPase/Zn-binding domain interface [polypeptide binding]; other site 683837005731 GTP/Mg2+ binding site [chemical binding]; other site 683837005732 G4 box; other site 683837005733 G1 box; other site 683837005734 Switch I region; other site 683837005735 G2 box; other site 683837005736 G3 box; other site 683837005737 Switch II region; other site 683837005738 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 683837005739 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 683837005740 active site 683837005741 ATP binding site [chemical binding]; other site 683837005742 substrate binding site [chemical binding]; other site 683837005743 activation loop (A-loop); other site 683837005744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 683837005745 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 683837005746 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 683837005747 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 683837005748 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 683837005749 Protein phosphatase 2C; Region: PP2C; pfam00481 683837005750 active site 683837005751 16S rRNA methyltransferase B; Provisional; Region: PRK14902 683837005752 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 683837005753 putative RNA binding site [nucleotide binding]; other site 683837005754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837005755 S-adenosylmethionine binding site [chemical binding]; other site 683837005756 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 683837005757 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 683837005758 putative active site [active] 683837005759 substrate binding site [chemical binding]; other site 683837005760 putative cosubstrate binding site; other site 683837005761 catalytic site [active] 683837005762 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 683837005763 substrate binding site [chemical binding]; other site 683837005764 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 683837005765 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 683837005766 ATP binding site [chemical binding]; other site 683837005767 putative Mg++ binding site [ion binding]; other site 683837005768 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 683837005769 ATP-binding site [chemical binding]; other site 683837005770 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 683837005771 Flavoprotein; Region: Flavoprotein; pfam02441 683837005772 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 683837005773 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 683837005774 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 683837005775 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 683837005776 catalytic site [active] 683837005777 G-X2-G-X-G-K; other site 683837005778 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 683837005779 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 683837005780 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 683837005781 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 683837005782 Domain of unknown function (DUF814); Region: DUF814; pfam05670 683837005783 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 683837005784 NADH(P)-binding; Region: NAD_binding_10; pfam13460 683837005785 putative NAD(P) binding site [chemical binding]; other site 683837005786 homodimer interface [polypeptide binding]; other site 683837005787 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 683837005788 active site 683837005789 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 683837005790 active site 683837005791 dimer interface [polypeptide binding]; other site 683837005792 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 683837005793 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 683837005794 heterodimer interface [polypeptide binding]; other site 683837005795 active site 683837005796 FMN binding site [chemical binding]; other site 683837005797 homodimer interface [polypeptide binding]; other site 683837005798 substrate binding site [chemical binding]; other site 683837005799 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 683837005800 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 683837005801 FAD binding pocket [chemical binding]; other site 683837005802 FAD binding motif [chemical binding]; other site 683837005803 phosphate binding motif [ion binding]; other site 683837005804 beta-alpha-beta structure motif; other site 683837005805 NAD binding pocket [chemical binding]; other site 683837005806 Iron coordination center [ion binding]; other site 683837005807 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 683837005808 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 683837005809 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 683837005810 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 683837005811 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 683837005812 ATP-grasp domain; Region: ATP-grasp_4; cl17255 683837005813 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 683837005814 IMP binding site; other site 683837005815 dimer interface [polypeptide binding]; other site 683837005816 interdomain contacts; other site 683837005817 partial ornithine binding site; other site 683837005818 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 683837005819 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 683837005820 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 683837005821 catalytic site [active] 683837005822 subunit interface [polypeptide binding]; other site 683837005823 dihydroorotase; Validated; Region: pyrC; PRK09357 683837005824 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 683837005825 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 683837005826 active site 683837005827 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 683837005828 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 683837005829 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 683837005830 uracil transporter; Provisional; Region: PRK10720 683837005831 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 683837005832 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 683837005833 active site 683837005834 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 683837005835 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 683837005836 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 683837005837 RNA binding surface [nucleotide binding]; other site 683837005838 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 683837005839 active site 683837005840 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 683837005841 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 683837005842 Sulfate transporter family; Region: Sulfate_transp; pfam00916 683837005843 multidrug efflux protein; Reviewed; Region: PRK01766 683837005844 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 683837005845 cation binding site [ion binding]; other site 683837005846 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 683837005847 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 683837005848 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 683837005849 metal binding site [ion binding]; metal-binding site 683837005850 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 683837005851 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 683837005852 ABC-ATPase subunit interface; other site 683837005853 dimer interface [polypeptide binding]; other site 683837005854 putative PBP binding regions; other site 683837005855 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 683837005856 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 683837005857 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 683837005858 MarR family; Region: MarR; pfam01047 683837005859 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 683837005860 C-terminal peptidase (prc); Region: prc; TIGR00225 683837005861 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 683837005862 protein binding site [polypeptide binding]; other site 683837005863 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 683837005864 Catalytic dyad [active] 683837005865 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 683837005866 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 683837005867 metal-binding site [ion binding] 683837005868 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 683837005869 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 683837005870 metal-binding site [ion binding] 683837005871 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 683837005872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837005873 motif II; other site 683837005874 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 683837005875 putative homodimer interface [polypeptide binding]; other site 683837005876 putative homotetramer interface [polypeptide binding]; other site 683837005877 allosteric switch controlling residues; other site 683837005878 putative metal binding site [ion binding]; other site 683837005879 putative homodimer-homodimer interface [polypeptide binding]; other site 683837005880 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 683837005881 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 683837005882 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 683837005883 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 683837005884 hypothetical protein; Provisional; Region: PRK13672 683837005885 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 683837005886 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 683837005887 methionine sulfoxide reductase B; Provisional; Region: PRK00222 683837005888 SelR domain; Region: SelR; pfam01641 683837005889 methionine sulfoxide reductase A; Provisional; Region: PRK14054 683837005890 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 683837005891 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 683837005892 active site 683837005893 catalytic triad [active] 683837005894 oxyanion hole [active] 683837005895 EDD domain protein, DegV family; Region: DegV; TIGR00762 683837005896 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 683837005897 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 683837005898 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 683837005899 HTH domain; Region: HTH_11; pfam08279 683837005900 FOG: CBS domain [General function prediction only]; Region: COG0517 683837005901 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 683837005902 PEP synthetase regulatory protein; Provisional; Region: PRK05339 683837005903 pyruvate phosphate dikinase; Provisional; Region: PRK09279 683837005904 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 683837005905 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 683837005906 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 683837005907 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 683837005908 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837005909 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837005910 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837005911 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 683837005912 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 683837005913 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 683837005914 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 683837005915 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 683837005916 Predicted membrane protein [Function unknown]; Region: COG4129 683837005917 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 683837005918 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 683837005919 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 683837005920 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 683837005921 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 683837005922 active site 683837005923 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 683837005924 substrate binding site [chemical binding]; other site 683837005925 metal binding site [ion binding]; metal-binding site 683837005926 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 683837005927 Methyltransferase domain; Region: Methyltransf_11; pfam08241 683837005928 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 683837005929 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 683837005930 folate binding site [chemical binding]; other site 683837005931 NADP+ binding site [chemical binding]; other site 683837005932 thymidylate synthase; Region: thym_sym; TIGR03284 683837005933 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 683837005934 dimerization interface [polypeptide binding]; other site 683837005935 active site 683837005936 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 683837005937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837005938 Walker A/P-loop; other site 683837005939 ATP binding site [chemical binding]; other site 683837005940 Q-loop/lid; other site 683837005941 ABC transporter signature motif; other site 683837005942 Walker B; other site 683837005943 D-loop; other site 683837005944 H-loop/switch region; other site 683837005945 ABC transporter; Region: ABC_tran_2; pfam12848 683837005946 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 683837005947 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 683837005948 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 683837005949 Potassium binding sites [ion binding]; other site 683837005950 Cesium cation binding sites [ion binding]; other site 683837005951 manganese transport transcriptional regulator; Provisional; Region: PRK03902 683837005952 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 683837005953 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 683837005954 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 683837005955 DNA-binding site [nucleotide binding]; DNA binding site 683837005956 RNA-binding motif; other site 683837005957 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 683837005958 RNA/DNA hybrid binding site [nucleotide binding]; other site 683837005959 active site 683837005960 5'-3' exonuclease; Region: 53EXOc; smart00475 683837005961 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 683837005962 active site 683837005963 metal binding site 1 [ion binding]; metal-binding site 683837005964 putative 5' ssDNA interaction site; other site 683837005965 metal binding site 3; metal-binding site 683837005966 metal binding site 2 [ion binding]; metal-binding site 683837005967 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 683837005968 putative DNA binding site [nucleotide binding]; other site 683837005969 putative metal binding site [ion binding]; other site 683837005970 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 683837005971 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 683837005972 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 683837005973 putative active site [active] 683837005974 xanthine permease; Region: pbuX; TIGR03173 683837005975 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 683837005976 active site 683837005977 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 683837005978 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 683837005979 active site 683837005980 Zn binding site [ion binding]; other site 683837005981 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 683837005982 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 683837005983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 683837005984 cell division protein GpsB; Provisional; Region: PRK14127 683837005985 DivIVA domain; Region: DivI1A_domain; TIGR03544 683837005986 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 683837005987 hypothetical protein; Provisional; Region: PRK13660 683837005988 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 683837005989 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 683837005990 Transglycosylase; Region: Transgly; pfam00912 683837005991 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 683837005992 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 683837005993 Transcriptional regulator [Transcription]; Region: LysR; COG0583 683837005994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 683837005995 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 683837005996 dimerization interface [polypeptide binding]; other site 683837005997 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 683837005998 dimer interface [polypeptide binding]; other site 683837005999 FMN binding site [chemical binding]; other site 683837006000 NADPH bind site [chemical binding]; other site 683837006001 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 683837006002 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 683837006003 minor groove reading motif; other site 683837006004 helix-hairpin-helix signature motif; other site 683837006005 substrate binding pocket [chemical binding]; other site 683837006006 active site 683837006007 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 683837006008 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 683837006009 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 683837006010 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 683837006011 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 683837006012 putative dimer interface [polypeptide binding]; other site 683837006013 putative anticodon binding site; other site 683837006014 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 683837006015 homodimer interface [polypeptide binding]; other site 683837006016 motif 1; other site 683837006017 motif 2; other site 683837006018 active site 683837006019 motif 3; other site 683837006020 aspartate aminotransferase; Provisional; Region: PRK05764 683837006021 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 683837006022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837006023 homodimer interface [polypeptide binding]; other site 683837006024 catalytic residue [active] 683837006025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 683837006026 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 683837006027 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 683837006028 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 683837006029 active site 683837006030 catalytic site [active] 683837006031 substrate binding site [chemical binding]; other site 683837006032 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 683837006033 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 683837006034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 683837006035 putative Mg++ binding site [ion binding]; other site 683837006036 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 683837006037 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 683837006038 tetramerization interface [polypeptide binding]; other site 683837006039 active site 683837006040 pantoate--beta-alanine ligase; Region: panC; TIGR00018 683837006041 Pantoate-beta-alanine ligase; Region: PanC; cd00560 683837006042 active site 683837006043 ATP-binding site [chemical binding]; other site 683837006044 pantoate-binding site; other site 683837006045 HXXH motif; other site 683837006046 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 683837006047 active site 683837006048 oligomerization interface [polypeptide binding]; other site 683837006049 metal binding site [ion binding]; metal-binding site 683837006050 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 683837006051 catalytic residues [active] 683837006052 Biotin operon repressor [Transcription]; Region: BirA; COG1654 683837006053 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 683837006054 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 683837006055 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 683837006056 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 683837006057 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 683837006058 active site 683837006059 NTP binding site [chemical binding]; other site 683837006060 metal binding triad [ion binding]; metal-binding site 683837006061 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 683837006062 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 683837006063 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 683837006064 active site 683837006065 dimer interfaces [polypeptide binding]; other site 683837006066 catalytic residues [active] 683837006067 dihydrodipicolinate reductase; Provisional; Region: PRK00048 683837006068 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 683837006069 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 683837006070 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 683837006071 homodimer interface [polypeptide binding]; other site 683837006072 metal binding site [ion binding]; metal-binding site 683837006073 Uncharacterized conserved protein [Function unknown]; Region: COG1284 683837006074 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 683837006075 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 683837006076 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 683837006077 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 683837006078 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 683837006079 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 683837006080 metal binding site [ion binding]; metal-binding site 683837006081 active site 683837006082 I-site; other site 683837006083 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 683837006084 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 683837006085 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 683837006086 metal binding site [ion binding]; metal-binding site 683837006087 active site 683837006088 I-site; other site 683837006089 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 683837006090 malate dehydrogenase; Provisional; Region: PRK13529 683837006091 Malic enzyme, N-terminal domain; Region: malic; pfam00390 683837006092 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 683837006093 NAD(P) binding pocket [chemical binding]; other site 683837006094 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 683837006095 Beta-lactamase; Region: Beta-lactamase; pfam00144 683837006096 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 683837006097 Pyruvate formate lyase 1; Region: PFL1; cd01678 683837006098 coenzyme A binding site [chemical binding]; other site 683837006099 active site 683837006100 catalytic residues [active] 683837006101 glycine loop; other site 683837006102 HI0933-like protein; Region: HI0933_like; pfam03486 683837006103 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 683837006104 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 683837006105 Predicted membrane protein [Function unknown]; Region: COG4347 683837006106 hypothetical protein; Provisional; Region: PRK03636 683837006107 UPF0302 domain; Region: UPF0302; pfam08864 683837006108 IDEAL domain; Region: IDEAL; pfam08858 683837006109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 683837006110 binding surface 683837006111 TPR motif; other site 683837006112 TPR repeat; Region: TPR_11; pfam13414 683837006113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 683837006114 binding surface 683837006115 TPR motif; other site 683837006116 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 683837006117 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 683837006118 hinge; other site 683837006119 active site 683837006120 prephenate dehydrogenase; Validated; Region: PRK06545 683837006121 prephenate dehydrogenase; Validated; Region: PRK08507 683837006122 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 683837006123 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 683837006124 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 683837006125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837006126 homodimer interface [polypeptide binding]; other site 683837006127 catalytic residue [active] 683837006128 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 683837006129 homotrimer interaction site [polypeptide binding]; other site 683837006130 active site 683837006131 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 683837006132 active site 683837006133 dimer interface [polypeptide binding]; other site 683837006134 metal binding site [ion binding]; metal-binding site 683837006135 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 683837006136 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 683837006137 Tetramer interface [polypeptide binding]; other site 683837006138 active site 683837006139 FMN-binding site [chemical binding]; other site 683837006140 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 683837006141 active site 683837006142 multimer interface [polypeptide binding]; other site 683837006143 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 683837006144 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 683837006145 substrate binding pocket [chemical binding]; other site 683837006146 chain length determination region; other site 683837006147 substrate-Mg2+ binding site; other site 683837006148 catalytic residues [active] 683837006149 aspartate-rich region 1; other site 683837006150 active site lid residues [active] 683837006151 aspartate-rich region 2; other site 683837006152 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 683837006153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837006154 S-adenosylmethionine binding site [chemical binding]; other site 683837006155 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 683837006156 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 683837006157 homodecamer interface [polypeptide binding]; other site 683837006158 GTP cyclohydrolase I; Provisional; Region: PLN03044 683837006159 active site 683837006160 putative catalytic site residues [active] 683837006161 zinc binding site [ion binding]; other site 683837006162 GTP-CH-I/GFRP interaction surface; other site 683837006163 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 683837006164 IHF dimer interface [polypeptide binding]; other site 683837006165 IHF - DNA interface [nucleotide binding]; other site 683837006166 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 683837006167 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 683837006168 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 683837006169 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 683837006170 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 683837006171 GTP-binding protein Der; Reviewed; Region: PRK00093 683837006172 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 683837006173 G1 box; other site 683837006174 GTP/Mg2+ binding site [chemical binding]; other site 683837006175 Switch I region; other site 683837006176 G2 box; other site 683837006177 Switch II region; other site 683837006178 G3 box; other site 683837006179 G4 box; other site 683837006180 G5 box; other site 683837006181 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 683837006182 G1 box; other site 683837006183 GTP/Mg2+ binding site [chemical binding]; other site 683837006184 Switch I region; other site 683837006185 G2 box; other site 683837006186 G3 box; other site 683837006187 Switch II region; other site 683837006188 G4 box; other site 683837006189 G5 box; other site 683837006192 cytidylate kinase; Provisional; Region: cmk; PRK00023 683837006193 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 683837006194 CMP-binding site; other site 683837006195 The sites determining sugar specificity; other site 683837006196 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 683837006197 active site 683837006198 homotetramer interface [polypeptide binding]; other site 683837006199 homodimer interface [polypeptide binding]; other site 683837006200 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 683837006201 DEAD-like helicases superfamily; Region: DEXDc; smart00487 683837006202 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 683837006203 ATP binding site [chemical binding]; other site 683837006204 putative Mg++ binding site [ion binding]; other site 683837006205 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 683837006206 nucleotide binding region [chemical binding]; other site 683837006207 ATP-binding site [chemical binding]; other site 683837006208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 683837006209 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 683837006210 Predicted membrane protein [Function unknown]; Region: COG3601 683837006211 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 683837006212 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 683837006213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 683837006214 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 683837006215 dimerization interface [polypeptide binding]; other site 683837006216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 683837006217 dimer interface [polypeptide binding]; other site 683837006218 phosphorylation site [posttranslational modification] 683837006219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837006220 ATP binding site [chemical binding]; other site 683837006221 Mg2+ binding site [ion binding]; other site 683837006222 G-X-G motif; other site 683837006223 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 683837006224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837006225 active site 683837006226 phosphorylation site [posttranslational modification] 683837006227 intermolecular recognition site; other site 683837006228 dimerization interface [polypeptide binding]; other site 683837006229 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 683837006230 DNA binding site [nucleotide binding] 683837006231 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 683837006232 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 683837006233 RNA binding surface [nucleotide binding]; other site 683837006234 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 683837006235 active site 683837006236 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 683837006237 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 683837006238 diaminopimelate decarboxylase; Region: lysA; TIGR01048 683837006239 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 683837006240 active site 683837006241 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 683837006242 substrate binding site [chemical binding]; other site 683837006243 catalytic residues [active] 683837006244 dimer interface [polypeptide binding]; other site 683837006245 purine nucleoside phosphorylase; Provisional; Region: PRK08202 683837006246 phosphopentomutase; Provisional; Region: PRK05362 683837006247 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 683837006248 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 683837006249 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 683837006250 active site 683837006251 Int/Topo IB signature motif; other site 683837006252 ferric uptake regulator; Provisional; Region: fur; PRK09462 683837006253 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 683837006254 metal binding site 2 [ion binding]; metal-binding site 683837006255 putative DNA binding helix; other site 683837006256 metal binding site 1 [ion binding]; metal-binding site 683837006257 dimer interface [polypeptide binding]; other site 683837006258 structural Zn2+ binding site [ion binding]; other site 683837006259 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 683837006260 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 683837006261 ABC-ATPase subunit interface; other site 683837006262 dimer interface [polypeptide binding]; other site 683837006263 putative PBP binding regions; other site 683837006264 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 683837006265 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 683837006266 ABC-ATPase subunit interface; other site 683837006267 dimer interface [polypeptide binding]; other site 683837006268 putative PBP binding regions; other site 683837006269 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 683837006270 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 683837006271 putative ligand binding residues [chemical binding]; other site 683837006272 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 683837006273 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 683837006274 Walker A/P-loop; other site 683837006275 ATP binding site [chemical binding]; other site 683837006276 Q-loop/lid; other site 683837006277 ABC transporter signature motif; other site 683837006278 Walker B; other site 683837006279 D-loop; other site 683837006280 H-loop/switch region; other site 683837006281 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 683837006282 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 683837006283 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 683837006284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 683837006285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 683837006286 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 683837006287 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 683837006288 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 683837006289 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 683837006290 Walker A/P-loop; other site 683837006291 ATP binding site [chemical binding]; other site 683837006292 Q-loop/lid; other site 683837006293 ABC transporter signature motif; other site 683837006294 Walker B; other site 683837006295 D-loop; other site 683837006296 H-loop/switch region; other site 683837006297 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 683837006298 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 683837006299 dimer interface [polypeptide binding]; other site 683837006300 ADP-ribose binding site [chemical binding]; other site 683837006301 active site 683837006302 nudix motif; other site 683837006303 metal binding site [ion binding]; metal-binding site 683837006304 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 683837006305 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 683837006306 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 683837006307 active site 683837006308 DNA polymerase IV; Validated; Region: PRK02406 683837006309 DNA binding site [nucleotide binding] 683837006310 Transcription factor S-II (TFIIS), central domain; Region: TFIIS_M; cl02637 683837006311 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 683837006312 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 683837006313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 683837006314 NAD(P) binding site [chemical binding]; other site 683837006315 active site 683837006316 ribonuclease Z; Region: RNase_Z; TIGR02651 683837006317 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 683837006318 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 683837006319 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 683837006320 Uncharacterized conserved protein [Function unknown]; Region: COG5506 683837006321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 683837006322 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 683837006323 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 683837006324 6-phosphogluconate dehydratase; Region: edd; TIGR01196 683837006325 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 683837006326 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 683837006327 PYR/PP interface [polypeptide binding]; other site 683837006328 dimer interface [polypeptide binding]; other site 683837006329 TPP binding site [chemical binding]; other site 683837006330 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 683837006331 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 683837006332 TPP-binding site [chemical binding]; other site 683837006333 dimer interface [polypeptide binding]; other site 683837006334 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 683837006335 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 683837006336 putative valine binding site [chemical binding]; other site 683837006337 dimer interface [polypeptide binding]; other site 683837006338 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 683837006339 ketol-acid reductoisomerase; Provisional; Region: PRK05479 683837006340 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 683837006341 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 683837006342 2-isopropylmalate synthase; Validated; Region: PRK00915 683837006343 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 683837006344 active site 683837006345 catalytic residues [active] 683837006346 metal binding site [ion binding]; metal-binding site 683837006347 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 683837006348 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 683837006349 tartrate dehydrogenase; Region: TTC; TIGR02089 683837006350 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 683837006351 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 683837006352 substrate binding site [chemical binding]; other site 683837006353 ligand binding site [chemical binding]; other site 683837006354 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 683837006355 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 683837006356 substrate binding site [chemical binding]; other site 683837006357 threonine dehydratase; Validated; Region: PRK08639 683837006358 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 683837006359 tetramer interface [polypeptide binding]; other site 683837006360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837006361 catalytic residue [active] 683837006362 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 683837006363 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 683837006364 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 683837006365 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 683837006366 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 683837006367 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 683837006368 Transcriptional regulators [Transcription]; Region: PurR; COG1609 683837006369 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 683837006370 DNA binding site [nucleotide binding] 683837006371 domain linker motif; other site 683837006372 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 683837006373 dimerization interface [polypeptide binding]; other site 683837006374 ligand binding site [chemical binding]; other site 683837006375 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 683837006376 intersubunit interface [polypeptide binding]; other site 683837006377 active site 683837006378 catalytic residue [active] 683837006379 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 683837006380 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 683837006381 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 683837006382 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 683837006383 active pocket/dimerization site; other site 683837006384 active site 683837006385 phosphorylation site [posttranslational modification] 683837006386 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 683837006387 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 683837006388 putative active site [active] 683837006389 SIS domain; Region: SIS; pfam01380 683837006390 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 683837006391 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 683837006392 dimer interface [polypeptide binding]; other site 683837006393 active site 683837006394 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 683837006395 dimer interface [polypeptide binding]; other site 683837006396 active site 683837006397 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 683837006398 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 683837006399 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 683837006400 active site 683837006401 phosphorylation site [posttranslational modification] 683837006402 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 683837006403 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837006404 DNA-binding site [nucleotide binding]; DNA binding site 683837006405 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 683837006406 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 683837006407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837006408 DNA-binding site [nucleotide binding]; DNA binding site 683837006409 UTRA domain; Region: UTRA; pfam07702 683837006410 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 683837006411 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 683837006412 active site 683837006413 catalytic tetrad [active] 683837006414 acetolactate synthase; Reviewed; Region: PRK08617 683837006415 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 683837006416 PYR/PP interface [polypeptide binding]; other site 683837006417 dimer interface [polypeptide binding]; other site 683837006418 TPP binding site [chemical binding]; other site 683837006419 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 683837006420 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 683837006421 TPP-binding site [chemical binding]; other site 683837006422 dimer interface [polypeptide binding]; other site 683837006423 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 683837006424 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 683837006425 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 683837006426 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 683837006427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837006428 ABC-ATPase subunit interface; other site 683837006429 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 683837006430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837006431 ABC-ATPase subunit interface; other site 683837006432 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 683837006433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837006434 active site 683837006435 phosphorylation site [posttranslational modification] 683837006436 intermolecular recognition site; other site 683837006437 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 683837006438 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 683837006439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 683837006440 dimerization interface [polypeptide binding]; other site 683837006441 Histidine kinase; Region: His_kinase; pfam06580 683837006442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837006443 ATP binding site [chemical binding]; other site 683837006444 Mg2+ binding site [ion binding]; other site 683837006445 G-X-G motif; other site 683837006446 Predicted integral membrane protein [Function unknown]; Region: COG5578 683837006447 Uncharacterized conserved protein [Function unknown]; Region: COG3538 683837006448 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 683837006449 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 683837006450 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 683837006451 active site 683837006452 metal binding site [ion binding]; metal-binding site 683837006453 homodimer interface [polypeptide binding]; other site 683837006454 catalytic site [active] 683837006455 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 683837006456 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 683837006457 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 683837006458 active site 683837006459 catalytic site [active] 683837006460 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 683837006461 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 683837006462 DNA-binding site [nucleotide binding]; DNA binding site 683837006463 RNA-binding motif; other site 683837006464 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 683837006465 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 683837006466 active site 683837006467 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 683837006468 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 683837006469 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 683837006470 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 683837006471 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 683837006472 active site 683837006473 HIGH motif; other site 683837006474 nucleotide binding site [chemical binding]; other site 683837006475 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 683837006476 active site 683837006477 KMSKS motif; other site 683837006478 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 683837006479 tRNA binding surface [nucleotide binding]; other site 683837006480 anticodon binding site; other site 683837006481 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 683837006482 DivIVA protein; Region: DivIVA; pfam05103 683837006483 DivIVA domain; Region: DivI1A_domain; TIGR03544 683837006484 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 683837006485 HTH domain; Region: HTH_11; pfam08279 683837006486 3H domain; Region: 3H; pfam02829 683837006487 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 683837006488 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 683837006489 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 683837006490 catalytic residue [active] 683837006491 L-aspartate oxidase; Provisional; Region: PRK08071 683837006492 L-aspartate oxidase; Provisional; Region: PRK06175 683837006493 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 683837006494 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 683837006495 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 683837006496 dimerization interface [polypeptide binding]; other site 683837006497 active site 683837006498 quinolinate synthetase; Provisional; Region: PRK09375 683837006499 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 683837006500 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 683837006501 RNA binding surface [nucleotide binding]; other site 683837006502 YGGT family; Region: YGGT; pfam02325 683837006503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 683837006504 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 683837006505 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 683837006506 catalytic residue [active] 683837006507 cell division protein FtsZ; Validated; Region: PRK09330 683837006508 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 683837006509 nucleotide binding site [chemical binding]; other site 683837006510 SulA interaction site; other site 683837006511 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 683837006512 Cell division protein FtsA; Region: FtsA; smart00842 683837006513 Cell division protein FtsA; Region: FtsA; pfam14450 683837006514 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 683837006515 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 683837006516 Cell division protein FtsQ; Region: FtsQ; pfam03799 683837006517 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 683837006518 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 683837006519 active site 683837006520 homodimer interface [polypeptide binding]; other site 683837006521 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 683837006522 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 683837006523 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 683837006524 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 683837006525 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 683837006526 Mg++ binding site [ion binding]; other site 683837006527 putative catalytic motif [active] 683837006528 putative substrate binding site [chemical binding]; other site 683837006529 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 683837006530 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 683837006531 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 683837006532 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 683837006533 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 683837006534 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 683837006535 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 683837006536 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 683837006537 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 683837006538 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 683837006539 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 683837006540 MraW methylase family; Region: Methyltransf_5; pfam01795 683837006541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 683837006542 MraZ protein; Region: MraZ; pfam02381 683837006543 MraZ protein; Region: MraZ; pfam02381 683837006544 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837006545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837006546 putative substrate translocation pore; other site 683837006547 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 683837006548 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 683837006549 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 683837006550 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 683837006551 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 683837006552 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 683837006553 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 683837006554 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 683837006555 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 683837006556 hypothetical protein; Provisional; Region: PRK13670 683837006557 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 683837006558 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 683837006559 AAA domain; Region: AAA_21; pfam13304 683837006560 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 683837006561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837006562 AAA domain; Region: AAA_21; pfam13304 683837006563 Walker A/P-loop; other site 683837006564 ATP binding site [chemical binding]; other site 683837006565 Q-loop/lid; other site 683837006566 ABC transporter signature motif; other site 683837006567 Walker B; other site 683837006568 D-loop; other site 683837006569 H-loop/switch region; other site 683837006570 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 683837006571 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 683837006572 protein binding site [polypeptide binding]; other site 683837006573 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 683837006574 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 683837006575 active site 683837006576 (T/H)XGH motif; other site 683837006577 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 683837006578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837006579 S-adenosylmethionine binding site [chemical binding]; other site 683837006580 hypothetical protein; Provisional; Region: PRK02886 683837006581 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 683837006582 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 683837006583 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 683837006584 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 683837006585 UbiA prenyltransferase family; Region: UbiA; pfam01040 683837006586 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 683837006587 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 683837006588 Ion transport protein; Region: Ion_trans; pfam00520 683837006589 Ion channel; Region: Ion_trans_2; pfam07885 683837006590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 683837006591 MOSC domain; Region: MOSC; pfam03473 683837006592 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 683837006593 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 683837006594 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 683837006595 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 683837006596 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 683837006597 LXG domain of WXG superfamily; Region: LXG; pfam04740 683837006598 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 683837006599 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 683837006600 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 683837006601 active site 683837006602 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 683837006603 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 683837006604 ring oligomerisation interface [polypeptide binding]; other site 683837006605 ATP/Mg binding site [chemical binding]; other site 683837006606 stacking interactions; other site 683837006607 hinge regions; other site 683837006608 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 683837006609 oligomerisation interface [polypeptide binding]; other site 683837006610 mobile loop; other site 683837006611 roof hairpin; other site 683837006612 CAAX protease self-immunity; Region: Abi; pfam02517 683837006613 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 683837006614 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 683837006615 CoA binding domain; Region: CoA_binding; pfam02629 683837006616 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 683837006617 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 683837006618 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 683837006619 ABC transporter; Region: ABC_tran_2; pfam12848 683837006620 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 683837006621 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 683837006622 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 683837006623 UGMP family protein; Validated; Region: PRK09604 683837006624 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 683837006625 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 683837006626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 683837006627 Coenzyme A binding pocket [chemical binding]; other site 683837006628 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 683837006629 Glycoprotease family; Region: Peptidase_M22; pfam00814 683837006630 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 683837006631 camphor resistance protein CrcB; Provisional; Region: PRK14214 683837006632 camphor resistance protein CrcB; Provisional; Region: PRK14231 683837006633 Uncharacterized conserved protein [Function unknown]; Region: COG4832 683837006634 Phosphotransferase enzyme family; Region: APH; pfam01636 683837006635 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 683837006636 active site 683837006637 substrate binding site [chemical binding]; other site 683837006638 ATP binding site [chemical binding]; other site 683837006639 Cna protein B-type domain; Region: Cna_B; pfam05738 683837006640 Cna protein B-type domain; Region: Cna_B; pfam05738 683837006641 Cna protein B-type domain; Region: Cna_B; pfam05738 683837006642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837006643 non-specific DNA binding site [nucleotide binding]; other site 683837006644 salt bridge; other site 683837006645 sequence-specific DNA binding site [nucleotide binding]; other site 683837006646 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 683837006647 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 683837006648 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 683837006649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 683837006650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 683837006651 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 683837006652 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 683837006653 argininosuccinate synthase; Provisional; Region: PRK13820 683837006654 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 683837006655 ANP binding site [chemical binding]; other site 683837006656 Substrate Binding Site II [chemical binding]; other site 683837006657 Substrate Binding Site I [chemical binding]; other site 683837006658 argininosuccinate lyase; Provisional; Region: PRK00855 683837006659 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 683837006660 active sites [active] 683837006661 tetramer interface [polypeptide binding]; other site 683837006662 BCCT family transporter; Region: BCCT; pfam02028 683837006663 hypothetical protein; Provisional; Region: PRK06357 683837006664 active site 683837006665 intersubunit interface [polypeptide binding]; other site 683837006666 Zn2+ binding site [ion binding]; other site 683837006667 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 683837006668 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 683837006669 putative substrate binding site [chemical binding]; other site 683837006670 putative ATP binding site [chemical binding]; other site 683837006671 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 683837006672 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 683837006673 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 683837006674 active site 683837006675 P-loop; other site 683837006676 phosphorylation site [posttranslational modification] 683837006677 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 683837006678 active site 683837006679 phosphorylation site [posttranslational modification] 683837006680 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 683837006681 PRD domain; Region: PRD; pfam00874 683837006682 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 683837006683 active site 683837006684 P-loop; other site 683837006685 phosphorylation site [posttranslational modification] 683837006686 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 683837006687 active site 683837006688 phosphorylation site [posttranslational modification] 683837006689 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 683837006690 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837006691 DNA-binding site [nucleotide binding]; DNA binding site 683837006692 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 683837006693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837006694 homodimer interface [polypeptide binding]; other site 683837006695 catalytic residue [active] 683837006696 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 683837006697 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 683837006698 active site 683837006699 multimer interface [polypeptide binding]; other site 683837006700 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 683837006701 Glutamine amidotransferase class-I; Region: GATase; pfam00117 683837006702 predicted active site [active] 683837006703 catalytic triad [active] 683837006704 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 683837006705 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 683837006706 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 683837006707 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 683837006708 G1 box; other site 683837006709 GTP/Mg2+ binding site [chemical binding]; other site 683837006710 Switch I region; other site 683837006711 G2 box; other site 683837006712 G3 box; other site 683837006713 Switch II region; other site 683837006714 G4 box; other site 683837006715 G5 box; other site 683837006716 Nucleoside recognition; Region: Gate; pfam07670 683837006717 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 683837006718 Nucleoside recognition; Region: Gate; pfam07670 683837006719 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 683837006720 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 683837006721 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 683837006722 putative active site [active] 683837006723 putative metal binding site [ion binding]; other site 683837006724 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 683837006725 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 683837006726 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 683837006727 dimer interface [polypeptide binding]; other site 683837006728 FMN binding site [chemical binding]; other site 683837006729 NADPH bind site [chemical binding]; other site 683837006730 Helix-turn-helix domain; Region: HTH_17; pfam12728 683837006731 putative heme peroxidase; Provisional; Region: PRK12276 683837006732 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 683837006733 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 683837006734 Walker A/P-loop; other site 683837006735 ATP binding site [chemical binding]; other site 683837006736 Q-loop/lid; other site 683837006737 ABC transporter signature motif; other site 683837006738 Walker B; other site 683837006739 D-loop; other site 683837006740 H-loop/switch region; other site 683837006741 FtsX-like permease family; Region: FtsX; pfam02687 683837006742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 683837006743 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 683837006744 Coenzyme A binding pocket [chemical binding]; other site 683837006745 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 683837006746 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 683837006747 active site 683837006748 substrate binding site [chemical binding]; other site 683837006749 metal binding site [ion binding]; metal-binding site 683837006750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 683837006751 YbbR-like protein; Region: YbbR; pfam07949 683837006752 YbbR-like protein; Region: YbbR; pfam07949 683837006753 YbbR-like protein; Region: YbbR; pfam07949 683837006754 Uncharacterized conserved protein [Function unknown]; Region: COG1624 683837006755 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 683837006756 maltose phosphorylase; Provisional; Region: PRK13807 683837006757 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 683837006758 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 683837006759 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 683837006760 Predicted integral membrane protein [Function unknown]; Region: COG5521 683837006761 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 683837006762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837006763 dimer interface [polypeptide binding]; other site 683837006764 conserved gate region; other site 683837006765 putative PBP binding loops; other site 683837006766 ABC-ATPase subunit interface; other site 683837006767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837006768 dimer interface [polypeptide binding]; other site 683837006769 conserved gate region; other site 683837006770 putative PBP binding loops; other site 683837006771 ABC-ATPase subunit interface; other site 683837006772 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 683837006773 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 683837006774 maltodextrin glucosidase; Provisional; Region: PRK10785 683837006775 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 683837006776 homodimer interface [polypeptide binding]; other site 683837006777 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 683837006778 active site 683837006779 homodimer interface [polypeptide binding]; other site 683837006780 catalytic site [active] 683837006781 CAAX protease self-immunity; Region: Abi; pfam02517 683837006782 Transcriptional regulators [Transcription]; Region: PurR; COG1609 683837006783 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 683837006784 DNA binding site [nucleotide binding] 683837006785 domain linker motif; other site 683837006786 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 683837006787 ligand binding site [chemical binding]; other site 683837006788 dimerization interface [polypeptide binding]; other site 683837006789 Amino acid permease; Region: AA_permease_2; pfam13520 683837006790 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 683837006791 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 683837006792 ligand binding site [chemical binding]; other site 683837006793 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 683837006794 putative switch regulator; other site 683837006795 non-specific DNA interactions [nucleotide binding]; other site 683837006796 DNA binding site [nucleotide binding] 683837006797 sequence specific DNA binding site [nucleotide binding]; other site 683837006798 putative cAMP binding site [chemical binding]; other site 683837006799 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 683837006800 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 683837006801 ligand binding site [chemical binding]; other site 683837006802 flexible hinge region; other site 683837006803 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 683837006804 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 683837006805 intersubunit interface [polypeptide binding]; other site 683837006806 active site 683837006807 zinc binding site [ion binding]; other site 683837006808 Na+ binding site [ion binding]; other site 683837006809 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 683837006810 intersubunit interface [polypeptide binding]; other site 683837006811 active site 683837006812 zinc binding site [ion binding]; other site 683837006813 Na+ binding site [ion binding]; other site 683837006814 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 683837006815 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 683837006816 active site 683837006817 P-loop; other site 683837006818 phosphorylation site [posttranslational modification] 683837006819 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 683837006820 active site 683837006821 phosphorylation site [posttranslational modification] 683837006822 HTH domain; Region: HTH_11; pfam08279 683837006823 PRD domain; Region: PRD; pfam00874 683837006824 PRD domain; Region: PRD; pfam00874 683837006825 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 683837006826 active site 683837006827 P-loop; other site 683837006828 phosphorylation site [posttranslational modification] 683837006829 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 683837006830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837006831 Walker A/P-loop; other site 683837006832 ATP binding site [chemical binding]; other site 683837006833 Q-loop/lid; other site 683837006834 ABC transporter signature motif; other site 683837006835 Walker B; other site 683837006836 D-loop; other site 683837006837 H-loop/switch region; other site 683837006838 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 683837006839 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 683837006840 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 683837006841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 683837006842 Coenzyme A binding pocket [chemical binding]; other site 683837006843 Transcriptional regulators [Transcription]; Region: GntR; COG1802 683837006844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 683837006845 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 683837006846 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 683837006847 Transcriptional regulator [Transcription]; Region: LysR; COG0583 683837006848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 683837006849 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 683837006850 putative dimerization interface [polypeptide binding]; other site 683837006851 Predicted membrane protein [Function unknown]; Region: COG2855 683837006852 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 683837006853 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 683837006854 putative metal binding site [ion binding]; other site 683837006855 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 683837006856 homodimer interface [polypeptide binding]; other site 683837006857 chemical substrate binding site [chemical binding]; other site 683837006858 oligomer interface [polypeptide binding]; other site 683837006859 metal binding site [ion binding]; metal-binding site 683837006860 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 683837006861 catalytic residues [active] 683837006862 flavodoxin; Provisional; Region: PRK09271 683837006863 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 683837006864 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 683837006865 dimer interface [polypeptide binding]; other site 683837006866 putative radical transfer pathway; other site 683837006867 diiron center [ion binding]; other site 683837006868 tyrosyl radical; other site 683837006869 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 683837006870 Class I ribonucleotide reductase; Region: RNR_I; cd01679 683837006871 active site 683837006872 dimer interface [polypeptide binding]; other site 683837006873 catalytic residues [active] 683837006874 effector binding site; other site 683837006875 R2 peptide binding site; other site 683837006876 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 683837006877 CsbD-like; Region: CsbD; cl17424 683837006878 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 683837006879 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 683837006880 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 683837006881 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 683837006882 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 683837006883 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 683837006884 conserved cys residue [active] 683837006885 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 683837006886 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 683837006887 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 683837006888 Cupin; Region: Cupin_1; pfam00190 683837006889 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 683837006890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 683837006891 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 683837006892 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 683837006893 ligand binding site [chemical binding]; other site 683837006894 flexible hinge region; other site 683837006895 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 683837006896 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 683837006897 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 683837006898 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 683837006899 dimer interface [polypeptide binding]; other site 683837006900 active site 683837006901 metal binding site [ion binding]; metal-binding site 683837006902 glutathione binding site [chemical binding]; other site 683837006903 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 683837006904 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 683837006905 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 683837006906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 683837006907 metal binding site [ion binding]; metal-binding site 683837006908 active site 683837006909 I-site; other site 683837006910 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 683837006911 classical (c) SDRs; Region: SDR_c; cd05233 683837006912 NAD(P) binding site [chemical binding]; other site 683837006913 active site 683837006914 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 683837006915 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 683837006916 Tic20-like protein; Region: Tic20; pfam09685 683837006917 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 683837006918 Cna protein B-type domain; Region: Cna_B; pfam05738 683837006919 Collagen binding domain; Region: Collagen_bind; pfam05737 683837006920 Collagen binding domain; Region: Collagen_bind; pfam05737 683837006921 Cna protein B-type domain; Region: Cna_B; pfam05738 683837006922 Cna protein B-type domain; Region: Cna_B; pfam05738 683837006923 Cna protein B-type domain; Region: Cna_B; pfam05738 683837006924 Cna protein B-type domain; Region: Cna_B; pfam05738 683837006925 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 683837006926 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 683837006927 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 683837006928 active site 683837006929 catalytic site [active] 683837006930 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 683837006931 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 683837006932 Walker A/P-loop; other site 683837006933 ATP binding site [chemical binding]; other site 683837006934 Q-loop/lid; other site 683837006935 ABC transporter signature motif; other site 683837006936 Walker B; other site 683837006937 D-loop; other site 683837006938 H-loop/switch region; other site 683837006939 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 683837006940 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 683837006941 ABC-ATPase subunit interface; other site 683837006942 dimer interface [polypeptide binding]; other site 683837006943 putative PBP binding regions; other site 683837006944 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 683837006945 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 683837006946 intersubunit interface [polypeptide binding]; other site 683837006947 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 683837006948 heme-binding site [chemical binding]; other site 683837006949 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 683837006950 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 683837006951 heme-binding site [chemical binding]; other site 683837006952 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 683837006953 heme-binding site [chemical binding]; other site 683837006954 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 683837006955 heme-binding site [chemical binding]; other site 683837006956 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 683837006957 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 683837006958 oligoendopeptidase F; Region: pepF; TIGR00181 683837006959 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 683837006960 active site 683837006961 Zn binding site [ion binding]; other site 683837006962 Competence protein CoiA-like family; Region: CoiA; cl11541 683837006963 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 683837006964 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 683837006965 ArsC family; Region: ArsC; pfam03960 683837006966 putative catalytic residues [active] 683837006967 thiol/disulfide switch; other site 683837006968 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 683837006969 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 683837006970 Walker A/P-loop; other site 683837006971 ATP binding site [chemical binding]; other site 683837006972 Q-loop/lid; other site 683837006973 ABC transporter signature motif; other site 683837006974 Walker B; other site 683837006975 D-loop; other site 683837006976 H-loop/switch region; other site 683837006977 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 683837006978 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 683837006979 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 683837006980 Walker A/P-loop; other site 683837006981 ATP binding site [chemical binding]; other site 683837006982 Q-loop/lid; other site 683837006983 ABC transporter signature motif; other site 683837006984 Walker B; other site 683837006985 D-loop; other site 683837006986 H-loop/switch region; other site 683837006987 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 683837006988 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 683837006989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837006990 dimer interface [polypeptide binding]; other site 683837006991 conserved gate region; other site 683837006992 putative PBP binding loops; other site 683837006993 ABC-ATPase subunit interface; other site 683837006994 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 683837006995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837006996 dimer interface [polypeptide binding]; other site 683837006997 conserved gate region; other site 683837006998 putative PBP binding loops; other site 683837006999 ABC-ATPase subunit interface; other site 683837007000 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 683837007001 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 683837007002 peptide binding site [polypeptide binding]; other site 683837007003 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 683837007004 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 683837007005 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 683837007006 active site 683837007007 HIGH motif; other site 683837007008 dimer interface [polypeptide binding]; other site 683837007009 KMSKS motif; other site 683837007010 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 683837007011 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 683837007012 MarR family; Region: MarR; pfam01047 683837007013 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 683837007014 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 683837007015 dimer interface [polypeptide binding]; other site 683837007016 active site 683837007017 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 683837007018 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 683837007019 dimer interface [polypeptide binding]; other site 683837007020 active site 683837007021 CoA binding pocket [chemical binding]; other site 683837007022 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 683837007023 SH3-like domain; Region: SH3_8; pfam13457 683837007024 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 683837007025 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 683837007026 catalytic core [active] 683837007027 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 683837007028 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 683837007029 Clp amino terminal domain; Region: Clp_N; pfam02861 683837007030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837007031 Walker A motif; other site 683837007032 ATP binding site [chemical binding]; other site 683837007033 Walker B motif; other site 683837007034 arginine finger; other site 683837007035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837007036 Walker A motif; other site 683837007037 ATP binding site [chemical binding]; other site 683837007038 Walker B motif; other site 683837007039 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 683837007040 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 683837007041 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 683837007042 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 683837007043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837007044 active site 683837007045 motif I; other site 683837007046 motif II; other site 683837007047 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 683837007048 Predicted acetyltransferase [General function prediction only]; Region: COG3393 683837007049 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 683837007050 ferrochelatase; Provisional; Region: PRK12435 683837007051 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 683837007052 C-terminal domain interface [polypeptide binding]; other site 683837007053 active site 683837007054 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 683837007055 active site 683837007056 N-terminal domain interface [polypeptide binding]; other site 683837007057 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 683837007058 substrate binding site [chemical binding]; other site 683837007059 active site 683837007060 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 683837007061 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 683837007062 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 683837007063 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 683837007064 Walker A/P-loop; other site 683837007065 ATP binding site [chemical binding]; other site 683837007066 Q-loop/lid; other site 683837007067 ABC transporter signature motif; other site 683837007068 Walker B; other site 683837007069 D-loop; other site 683837007070 H-loop/switch region; other site 683837007071 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 683837007072 HIT family signature motif; other site 683837007073 catalytic residue [active] 683837007074 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 683837007075 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 683837007076 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 683837007077 SurA N-terminal domain; Region: SurA_N_3; cl07813 683837007078 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 683837007079 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 683837007080 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 683837007081 generic binding surface II; other site 683837007082 generic binding surface I; other site 683837007083 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 683837007084 Zn2+ binding site [ion binding]; other site 683837007085 Mg2+ binding site [ion binding]; other site 683837007086 Uncharacterized conserved protein [Function unknown]; Region: COG4717 683837007087 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 683837007088 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 683837007089 active site 683837007090 metal binding site [ion binding]; metal-binding site 683837007091 DNA binding site [nucleotide binding] 683837007092 hypothetical protein; Provisional; Region: PRK13676 683837007093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 683837007094 fumarate hydratase; Reviewed; Region: fumC; PRK00485 683837007095 Class II fumarases; Region: Fumarase_classII; cd01362 683837007096 active site 683837007097 tetramer interface [polypeptide binding]; other site 683837007098 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 683837007099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837007100 Walker A/P-loop; other site 683837007101 ATP binding site [chemical binding]; other site 683837007102 Q-loop/lid; other site 683837007103 ABC transporter signature motif; other site 683837007104 Walker B; other site 683837007105 D-loop; other site 683837007106 H-loop/switch region; other site 683837007107 Transglycosylase; Region: Transgly; pfam00912 683837007108 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 683837007109 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 683837007110 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 683837007111 Low molecular weight phosphatase family; Region: LMWPc; cl00105 683837007112 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 683837007113 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 683837007114 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 683837007115 Domain of unknown function DUF21; Region: DUF21; pfam01595 683837007116 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 683837007117 Transporter associated domain; Region: CorC_HlyC; smart01091 683837007118 Transcriptional regulator [Transcription]; Region: LysR; COG0583 683837007119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 683837007120 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 683837007121 putative dimerization interface [polypeptide binding]; other site 683837007122 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 683837007123 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 683837007124 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 683837007125 active site 683837007126 FMN binding site [chemical binding]; other site 683837007127 substrate binding site [chemical binding]; other site 683837007128 putative catalytic residue [active] 683837007129 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 683837007130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 683837007131 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 683837007132 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 683837007133 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 683837007134 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 683837007135 shikimate binding site; other site 683837007136 NAD(P) binding site [chemical binding]; other site 683837007137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837007138 putative substrate translocation pore; other site 683837007139 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837007140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837007141 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837007142 putative substrate translocation pore; other site 683837007143 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 683837007144 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 683837007145 Walker A/P-loop; other site 683837007146 ATP binding site [chemical binding]; other site 683837007147 ABC transporter signature motif; other site 683837007148 Walker B; other site 683837007149 D-loop; other site 683837007150 H-loop/switch region; other site 683837007151 Predicted transcriptional regulators [Transcription]; Region: COG1725 683837007152 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837007153 DNA-binding site [nucleotide binding]; DNA binding site 683837007154 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 683837007155 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 683837007156 DNA binding site [nucleotide binding] 683837007157 active site 683837007158 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 683837007159 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 683837007160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 683837007161 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 683837007162 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 683837007163 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 683837007164 active site 683837007165 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 683837007166 putative dimer interface [polypeptide binding]; other site 683837007167 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 683837007168 ligand binding site [chemical binding]; other site 683837007169 Zn binding site [ion binding]; other site 683837007170 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 683837007171 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 683837007172 active site 683837007173 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 683837007174 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 683837007175 active site 683837007176 catalytic tetrad [active] 683837007177 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 683837007178 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 683837007179 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 683837007180 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 683837007181 substrate binding pocket [chemical binding]; other site 683837007182 membrane-bound complex binding site; other site 683837007183 hinge residues; other site 683837007184 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 683837007185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837007186 dimer interface [polypeptide binding]; other site 683837007187 conserved gate region; other site 683837007188 putative PBP binding loops; other site 683837007189 ABC-ATPase subunit interface; other site 683837007190 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 683837007191 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 683837007192 Walker A/P-loop; other site 683837007193 ATP binding site [chemical binding]; other site 683837007194 Q-loop/lid; other site 683837007195 ABC transporter signature motif; other site 683837007196 Walker B; other site 683837007197 D-loop; other site 683837007198 H-loop/switch region; other site 683837007199 aspartate aminotransferase; Provisional; Region: PRK06348 683837007200 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 683837007201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837007202 homodimer interface [polypeptide binding]; other site 683837007203 catalytic residue [active] 683837007204 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 683837007205 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 683837007206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837007207 motif II; other site 683837007208 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 683837007209 intracellular protease, PfpI family; Region: PfpI; TIGR01382 683837007210 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 683837007211 proposed catalytic triad [active] 683837007212 conserved cys residue [active] 683837007213 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 683837007214 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 683837007215 methionine cluster; other site 683837007216 active site 683837007217 phosphorylation site [posttranslational modification] 683837007218 metal binding site [ion binding]; metal-binding site 683837007219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 683837007220 Coenzyme A binding pocket [chemical binding]; other site 683837007221 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 683837007222 esterase; Provisional; Region: PRK10566 683837007223 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 683837007224 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 683837007225 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 683837007226 motif II; other site 683837007227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837007228 Uncharacterized conserved protein [Function unknown]; Region: COG1284 683837007229 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 683837007230 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 683837007231 hypothetical protein; Provisional; Region: PRK13673 683837007232 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 683837007233 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 683837007234 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 683837007235 Part of AAA domain; Region: AAA_19; pfam13245 683837007236 Family description; Region: UvrD_C_2; pfam13538 683837007237 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 683837007238 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 683837007239 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 683837007240 A short protein domain of unknown function; Region: IDEAL; smart00914 683837007241 ComK protein; Region: ComK; pfam06338 683837007242 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 683837007243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837007244 non-specific DNA binding site [nucleotide binding]; other site 683837007245 salt bridge; other site 683837007246 sequence-specific DNA binding site [nucleotide binding]; other site 683837007247 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 683837007248 active site 683837007249 phosphorylation site [posttranslational modification] 683837007250 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 683837007251 active site 683837007252 P-loop; other site 683837007253 phosphorylation site [posttranslational modification] 683837007254 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 683837007255 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 683837007256 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 683837007257 putative substrate binding site [chemical binding]; other site 683837007258 putative ATP binding site [chemical binding]; other site 683837007259 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 683837007260 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 683837007261 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 683837007262 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 683837007263 trimer interface [polypeptide binding]; other site 683837007264 active site 683837007265 G bulge; other site 683837007266 Uncharacterized conserved protein [Function unknown]; Region: COG1683 683837007267 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 683837007268 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 683837007269 non-specific DNA interactions [nucleotide binding]; other site 683837007270 DNA binding site [nucleotide binding] 683837007271 sequence specific DNA binding site [nucleotide binding]; other site 683837007272 putative cAMP binding site [chemical binding]; other site 683837007273 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 683837007274 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 683837007275 substrate binding site [chemical binding]; other site 683837007276 ATP binding site [chemical binding]; other site 683837007277 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 683837007278 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 683837007279 RNA binding surface [nucleotide binding]; other site 683837007280 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 683837007281 active site 683837007282 uracil binding [chemical binding]; other site 683837007283 Predicted peptidase [General function prediction only]; Region: COG4099 683837007284 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 683837007285 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 683837007286 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 683837007287 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 683837007288 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 683837007289 active site 683837007290 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837007291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837007292 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837007293 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 683837007294 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 683837007295 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 683837007296 active site 683837007297 trimer interface [polypeptide binding]; other site 683837007298 allosteric site; other site 683837007299 active site lid [active] 683837007300 hexamer (dimer of trimers) interface [polypeptide binding]; other site 683837007301 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 683837007302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837007303 active site 683837007304 motif I; other site 683837007305 motif II; other site 683837007306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 683837007307 Predicted membrane protein [Function unknown]; Region: COG1511 683837007308 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 683837007309 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 683837007310 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 683837007311 Predicted transcriptional regulator [Transcription]; Region: COG1959 683837007312 Transcriptional regulator; Region: Rrf2; pfam02082 683837007313 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 683837007314 L-tyrosine decarboxylase; Provisional; Region: PRK13520 683837007315 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 683837007316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837007317 catalytic residue [active] 683837007318 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 683837007319 Mga helix-turn-helix domain; Region: Mga; pfam05043 683837007320 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 683837007321 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 683837007322 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 683837007323 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 683837007324 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 683837007325 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 683837007326 active site 683837007327 dimer interface [polypeptide binding]; other site 683837007328 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 683837007329 dimer interface [polypeptide binding]; other site 683837007330 active site 683837007331 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 683837007332 nudix motif; other site 683837007333 general stress protein 13; Validated; Region: PRK08059 683837007334 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 683837007335 RNA binding site [nucleotide binding]; other site 683837007336 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 683837007337 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 683837007338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837007339 homodimer interface [polypeptide binding]; other site 683837007340 catalytic residue [active] 683837007341 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 683837007342 FtsX-like permease family; Region: FtsX; pfam02687 683837007343 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 683837007344 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 683837007345 Walker A/P-loop; other site 683837007346 ATP binding site [chemical binding]; other site 683837007347 Q-loop/lid; other site 683837007348 ABC transporter signature motif; other site 683837007349 Walker B; other site 683837007350 D-loop; other site 683837007351 H-loop/switch region; other site 683837007352 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 683837007353 active site 683837007354 P-loop; other site 683837007355 phosphorylation site [posttranslational modification] 683837007356 aspartate kinase; Reviewed; Region: PRK09034 683837007357 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 683837007358 putative catalytic residues [active] 683837007359 putative nucleotide binding site [chemical binding]; other site 683837007360 putative aspartate binding site [chemical binding]; other site 683837007361 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 683837007362 allosteric regulatory residue; other site 683837007363 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 683837007364 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 683837007365 active site 683837007366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837007367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837007368 putative substrate translocation pore; other site 683837007369 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 683837007370 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 683837007371 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 683837007372 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 683837007373 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 683837007374 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 683837007375 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 683837007376 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 683837007377 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 683837007378 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 683837007379 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 683837007380 CoenzymeA binding site [chemical binding]; other site 683837007381 subunit interaction site [polypeptide binding]; other site 683837007382 PHB binding site; other site 683837007383 Divergent PAP2 family; Region: DUF212; pfam02681 683837007384 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 683837007385 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 683837007386 active site 683837007387 catalytic tetrad [active] 683837007388 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 683837007389 Cl- selectivity filter; other site 683837007390 Cl- binding residues [ion binding]; other site 683837007391 pore gating glutamate residue; other site 683837007392 dimer interface [polypeptide binding]; other site 683837007393 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 683837007394 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 683837007395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 683837007396 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 683837007397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 683837007398 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 683837007399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 683837007400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 683837007401 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 683837007402 NADH(P)-binding; Region: NAD_binding_10; pfam13460 683837007403 NAD(P) binding site [chemical binding]; other site 683837007404 putative active site [active] 683837007405 hypothetical protein; Provisional; Region: PRK13669 683837007406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 683837007407 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 683837007408 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 683837007409 tetramer interfaces [polypeptide binding]; other site 683837007410 binuclear metal-binding site [ion binding]; other site 683837007411 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 683837007412 Domain of unknown function DUF21; Region: DUF21; pfam01595 683837007413 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 683837007414 Transporter associated domain; Region: CorC_HlyC; smart01091 683837007415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 683837007416 Coenzyme A binding pocket [chemical binding]; other site 683837007417 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 683837007418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837007419 active site 683837007420 motif I; other site 683837007421 motif II; other site 683837007422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837007423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 683837007424 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 683837007425 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 683837007426 active site 683837007427 metal binding site [ion binding]; metal-binding site 683837007428 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 683837007429 Predicted permeases [General function prediction only]; Region: COG0730 683837007430 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 683837007431 Uncharacterized conserved protein [Function unknown]; Region: COG1801 683837007432 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 683837007433 FeS assembly protein SufB; Region: sufB; TIGR01980 683837007434 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 683837007435 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 683837007436 trimerization site [polypeptide binding]; other site 683837007437 active site 683837007438 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 683837007439 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 683837007440 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 683837007441 catalytic residue [active] 683837007442 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 683837007443 FeS assembly protein SufD; Region: sufD; TIGR01981 683837007444 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 683837007445 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 683837007446 Walker A/P-loop; other site 683837007447 ATP binding site [chemical binding]; other site 683837007448 Q-loop/lid; other site 683837007449 ABC transporter signature motif; other site 683837007450 Walker B; other site 683837007451 D-loop; other site 683837007452 H-loop/switch region; other site 683837007453 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 683837007454 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 683837007455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837007456 ABC-ATPase subunit interface; other site 683837007457 putative PBP binding loops; other site 683837007458 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 683837007459 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 683837007460 Walker A/P-loop; other site 683837007461 ATP binding site [chemical binding]; other site 683837007462 Q-loop/lid; other site 683837007463 ABC transporter signature motif; other site 683837007464 Walker B; other site 683837007465 D-loop; other site 683837007466 H-loop/switch region; other site 683837007467 NIL domain; Region: NIL; pfam09383 683837007468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 683837007469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 683837007470 dimer interface [polypeptide binding]; other site 683837007471 phosphorylation site [posttranslational modification] 683837007472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837007473 ATP binding site [chemical binding]; other site 683837007474 Mg2+ binding site [ion binding]; other site 683837007475 G-X-G motif; other site 683837007476 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 683837007477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837007478 active site 683837007479 phosphorylation site [posttranslational modification] 683837007480 intermolecular recognition site; other site 683837007481 dimerization interface [polypeptide binding]; other site 683837007482 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 683837007483 DNA binding site [nucleotide binding] 683837007484 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 683837007485 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 683837007486 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 683837007487 catalytic residues [active] 683837007488 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 683837007489 lipoyl attachment site [posttranslational modification]; other site 683837007490 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 683837007491 ArsC family; Region: ArsC; pfam03960 683837007492 putative ArsC-like catalytic residues; other site 683837007493 putative TRX-like catalytic residues [active] 683837007494 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 683837007495 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 683837007496 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 683837007497 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 683837007498 Walker A/P-loop; other site 683837007499 ATP binding site [chemical binding]; other site 683837007500 Q-loop/lid; other site 683837007501 ABC transporter signature motif; other site 683837007502 Walker B; other site 683837007503 D-loop; other site 683837007504 H-loop/switch region; other site 683837007505 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 683837007506 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 683837007507 ABC-ATPase subunit interface; other site 683837007508 dimer interface [polypeptide binding]; other site 683837007509 putative PBP binding regions; other site 683837007510 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 683837007511 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 683837007512 intersubunit interface [polypeptide binding]; other site 683837007513 Predicted esterase [General function prediction only]; Region: COG0627 683837007514 S-formylglutathione hydrolase; Region: PLN02442 683837007515 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 683837007516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837007517 catalytic residue [active] 683837007518 SdpI/YhfL protein family; Region: SdpI; pfam13630 683837007519 CAT RNA binding domain; Region: CAT_RBD; smart01061 683837007520 transcriptional antiterminator BglG; Provisional; Region: PRK09772 683837007521 PRD domain; Region: PRD; pfam00874 683837007522 PRD domain; Region: PRD; pfam00874 683837007523 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 683837007524 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 683837007525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 683837007526 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 683837007527 Predicted transcriptional regulator [Transcription]; Region: COG2378 683837007528 HTH domain; Region: HTH_11; pfam08279 683837007529 WYL domain; Region: WYL; pfam13280 683837007530 Uncharacterized conserved protein [Function unknown]; Region: COG1434 683837007531 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 683837007532 putative active site [active] 683837007533 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 683837007534 Leucine rich repeat; Region: LRR_8; pfam13855 683837007535 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 683837007536 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 683837007537 active site 683837007538 catalytic site [active] 683837007539 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 683837007540 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 683837007541 putative metal binding site [ion binding]; other site 683837007542 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 683837007543 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 683837007544 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 683837007545 active site 683837007546 catalytic site [active] 683837007547 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 683837007548 putative metal binding site [ion binding]; other site 683837007549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837007550 non-specific DNA binding site [nucleotide binding]; other site 683837007551 salt bridge; other site 683837007552 sequence-specific DNA binding site [nucleotide binding]; other site 683837007553 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 683837007554 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 683837007555 SmpB-tmRNA interface; other site 683837007556 ribonuclease R; Region: RNase_R; TIGR02063 683837007557 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 683837007558 RNB domain; Region: RNB; pfam00773 683837007559 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 683837007560 RNA binding site [nucleotide binding]; other site 683837007561 Esterase/lipase [General function prediction only]; Region: COG1647 683837007562 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 683837007563 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 683837007564 Esterase/lipase [General function prediction only]; Region: COG1647 683837007565 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 683837007566 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 683837007567 PGAP1-like protein; Region: PGAP1; pfam07819 683837007568 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 683837007569 enolase; Provisional; Region: eno; PRK00077 683837007570 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 683837007571 dimer interface [polypeptide binding]; other site 683837007572 metal binding site [ion binding]; metal-binding site 683837007573 substrate binding pocket [chemical binding]; other site 683837007574 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 683837007575 phosphoglyceromutase; Provisional; Region: PRK05434 683837007576 triosephosphate isomerase; Provisional; Region: PRK14567 683837007577 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 683837007578 substrate binding site [chemical binding]; other site 683837007579 dimer interface [polypeptide binding]; other site 683837007580 catalytic triad [active] 683837007581 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 683837007582 Phosphoglycerate kinase; Region: PGK; pfam00162 683837007583 substrate binding site [chemical binding]; other site 683837007584 hinge regions; other site 683837007585 ADP binding site [chemical binding]; other site 683837007586 catalytic site [active] 683837007587 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 683837007588 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 683837007589 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 683837007590 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 683837007591 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 683837007592 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 683837007593 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 683837007594 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 683837007595 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 683837007596 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 683837007597 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 683837007598 active site 683837007599 dimer interface [polypeptide binding]; other site 683837007600 MMPL family; Region: MMPL; pfam03176 683837007601 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 683837007602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 683837007603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 683837007604 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 683837007605 Clp protease; Region: CLP_protease; pfam00574 683837007606 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 683837007607 oligomer interface [polypeptide binding]; other site 683837007608 active site residues [active] 683837007609 amino acid transporter; Region: 2A0306; TIGR00909 683837007610 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 683837007611 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 683837007612 Leucine rich repeat; Region: LRR_8; pfam13855 683837007613 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 683837007614 Leucine rich repeat; Region: LRR_8; pfam13855 683837007615 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 683837007616 Leucine rich repeat; Region: LRR_8; pfam13855 683837007617 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 683837007618 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 683837007619 active site 683837007620 FMN binding site [chemical binding]; other site 683837007621 substrate binding site [chemical binding]; other site 683837007622 homotetramer interface [polypeptide binding]; other site 683837007623 catalytic residue [active] 683837007624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 683837007625 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 683837007626 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 683837007627 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 683837007628 phosphate binding site [ion binding]; other site 683837007629 putative substrate binding pocket [chemical binding]; other site 683837007630 dimer interface [polypeptide binding]; other site 683837007631 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 683837007632 AAA domain; Region: AAA_18; pfam13238 683837007633 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 683837007634 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 683837007635 active site 683837007636 substrate binding site [chemical binding]; other site 683837007637 metal binding site [ion binding]; metal-binding site 683837007638 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 683837007639 active site 683837007640 catalytic residues [active] 683837007641 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 683837007642 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 683837007643 NAD binding site [chemical binding]; other site 683837007644 homodimer interface [polypeptide binding]; other site 683837007645 active site 683837007646 substrate binding site [chemical binding]; other site 683837007647 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 683837007648 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 683837007649 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 683837007650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 683837007651 binding surface 683837007652 TPR motif; other site 683837007653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 683837007654 binding surface 683837007655 TPR motif; other site 683837007656 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 683837007657 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 683837007658 trimer interface [polypeptide binding]; other site 683837007659 active site 683837007660 substrate binding site [chemical binding]; other site 683837007661 CoA binding site [chemical binding]; other site 683837007662 pyrophosphatase PpaX; Provisional; Region: PRK13288 683837007663 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 683837007664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837007665 motif II; other site 683837007666 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 683837007667 HPr kinase/phosphorylase; Provisional; Region: PRK05428 683837007668 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 683837007669 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 683837007670 Hpr binding site; other site 683837007671 active site 683837007672 homohexamer subunit interaction site [polypeptide binding]; other site 683837007673 Predicted membrane protein [Function unknown]; Region: COG1950 683837007674 PspC domain; Region: PspC; pfam04024 683837007675 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 683837007676 Uncharacterized conserved protein [Function unknown]; Region: COG3595 683837007677 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 683837007678 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 683837007679 Uncharacterized conserved protein [Function unknown]; Region: COG3595 683837007680 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 683837007681 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 683837007682 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 683837007683 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 683837007684 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 683837007685 excinuclease ABC subunit B; Provisional; Region: PRK05298 683837007686 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 683837007687 ATP binding site [chemical binding]; other site 683837007688 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 683837007689 nucleotide binding region [chemical binding]; other site 683837007690 ATP-binding site [chemical binding]; other site 683837007691 Ultra-violet resistance protein B; Region: UvrB; pfam12344 683837007692 UvrB/uvrC motif; Region: UVR; pfam02151 683837007693 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 683837007694 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 683837007695 Zn2+ binding site [ion binding]; other site 683837007696 Mg2+ binding site [ion binding]; other site 683837007697 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 683837007698 dimerization interface [polypeptide binding]; other site 683837007699 putative DNA binding site [nucleotide binding]; other site 683837007700 putative Zn2+ binding site [ion binding]; other site 683837007701 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 683837007702 PhoU domain; Region: PhoU; pfam01895 683837007703 PhoU domain; Region: PhoU; pfam01895 683837007704 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 683837007705 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 683837007706 Walker A/P-loop; other site 683837007707 ATP binding site [chemical binding]; other site 683837007708 Q-loop/lid; other site 683837007709 ABC transporter signature motif; other site 683837007710 Walker B; other site 683837007711 D-loop; other site 683837007712 H-loop/switch region; other site 683837007713 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 683837007714 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 683837007715 Walker A/P-loop; other site 683837007716 ATP binding site [chemical binding]; other site 683837007717 Q-loop/lid; other site 683837007718 ABC transporter signature motif; other site 683837007719 Walker B; other site 683837007720 D-loop; other site 683837007721 H-loop/switch region; other site 683837007722 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 683837007723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837007724 dimer interface [polypeptide binding]; other site 683837007725 conserved gate region; other site 683837007726 putative PBP binding loops; other site 683837007727 ABC-ATPase subunit interface; other site 683837007728 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 683837007729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 683837007730 dimer interface [polypeptide binding]; other site 683837007731 conserved gate region; other site 683837007732 putative PBP binding loops; other site 683837007733 ABC-ATPase subunit interface; other site 683837007734 PBP superfamily domain; Region: PBP_like_2; cl17296 683837007735 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 683837007736 HAMP domain; Region: HAMP; pfam00672 683837007737 dimerization interface [polypeptide binding]; other site 683837007738 PAS domain; Region: PAS; smart00091 683837007739 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 683837007740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 683837007741 dimer interface [polypeptide binding]; other site 683837007742 phosphorylation site [posttranslational modification] 683837007743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837007744 ATP binding site [chemical binding]; other site 683837007745 G-X-G motif; other site 683837007746 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 683837007747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837007748 active site 683837007749 phosphorylation site [posttranslational modification] 683837007750 intermolecular recognition site; other site 683837007751 dimerization interface [polypeptide binding]; other site 683837007752 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 683837007753 DNA binding site [nucleotide binding] 683837007754 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 683837007755 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 683837007756 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 683837007757 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 683837007758 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 683837007759 putative active site [active] 683837007760 catalytic site [active] 683837007761 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 683837007762 putative active site [active] 683837007763 catalytic site [active] 683837007764 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 683837007765 Peptidase family M23; Region: Peptidase_M23; pfam01551 683837007766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 683837007767 NlpC/P60 family; Region: NLPC_P60; pfam00877 683837007768 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 683837007769 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 683837007770 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 683837007771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837007772 Walker A/P-loop; other site 683837007773 ATP binding site [chemical binding]; other site 683837007774 Q-loop/lid; other site 683837007775 ABC transporter signature motif; other site 683837007776 Walker B; other site 683837007777 D-loop; other site 683837007778 H-loop/switch region; other site 683837007779 Uncharacterized conserved protein [Function unknown]; Region: COG1284 683837007780 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 683837007781 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 683837007782 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 683837007783 peptide chain release factor 2; Provisional; Region: PRK06746 683837007784 This domain is found in peptide chain release factors; Region: PCRF; smart00937 683837007785 RF-1 domain; Region: RF-1; pfam00472 683837007786 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 683837007787 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 683837007788 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 683837007789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 683837007790 nucleotide binding region [chemical binding]; other site 683837007791 ATP-binding site [chemical binding]; other site 683837007792 SEC-C motif; Region: SEC-C; pfam02810 683837007793 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 683837007794 30S subunit binding site; other site 683837007795 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 683837007796 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 683837007797 active site 683837007798 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 683837007799 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 683837007800 ATP binding site [chemical binding]; other site 683837007801 putative Mg++ binding site [ion binding]; other site 683837007802 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 683837007803 nucleotide binding region [chemical binding]; other site 683837007804 ATP-binding site [chemical binding]; other site 683837007805 EDD domain protein, DegV family; Region: DegV; TIGR00762 683837007806 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 683837007807 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 683837007808 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 683837007809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837007810 active site 683837007811 phosphorylation site [posttranslational modification] 683837007812 intermolecular recognition site; other site 683837007813 dimerization interface [polypeptide binding]; other site 683837007814 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 683837007815 DNA binding residues [nucleotide binding] 683837007816 dimerization interface [polypeptide binding]; other site 683837007817 Uncharacterized conserved protein [Function unknown]; Region: COG1739 683837007818 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 683837007819 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 683837007820 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 683837007821 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 683837007822 Transcriptional regulator [Transcription]; Region: LytR; COG1316 683837007823 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 683837007824 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 683837007825 Mg++ binding site [ion binding]; other site 683837007826 putative catalytic motif [active] 683837007827 substrate binding site [chemical binding]; other site 683837007828 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 683837007829 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 683837007830 active site 683837007831 octamer interface [polypeptide binding]; other site 683837007832 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 683837007833 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 683837007834 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 683837007835 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 683837007836 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 683837007837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 683837007838 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 683837007839 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 683837007840 dimer interface [polypeptide binding]; other site 683837007841 ssDNA binding site [nucleotide binding]; other site 683837007842 tetramer (dimer of dimers) interface [polypeptide binding]; other site 683837007843 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 683837007844 rod shape-determining protein Mbl; Provisional; Region: PRK13928 683837007845 MreB and similar proteins; Region: MreB_like; cd10225 683837007846 nucleotide binding site [chemical binding]; other site 683837007847 Mg binding site [ion binding]; other site 683837007848 putative protofilament interaction site [polypeptide binding]; other site 683837007849 RodZ interaction site [polypeptide binding]; other site 683837007850 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 683837007851 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 683837007852 hinge; other site 683837007853 active site 683837007854 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 683837007855 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 683837007856 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 683837007857 gamma subunit interface [polypeptide binding]; other site 683837007858 epsilon subunit interface [polypeptide binding]; other site 683837007859 LBP interface [polypeptide binding]; other site 683837007860 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 683837007861 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 683837007862 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 683837007863 alpha subunit interaction interface [polypeptide binding]; other site 683837007864 Walker A motif; other site 683837007865 ATP binding site [chemical binding]; other site 683837007866 Walker B motif; other site 683837007867 inhibitor binding site; inhibition site 683837007868 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 683837007869 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 683837007870 core domain interface [polypeptide binding]; other site 683837007871 delta subunit interface [polypeptide binding]; other site 683837007872 epsilon subunit interface [polypeptide binding]; other site 683837007873 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 683837007874 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 683837007875 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 683837007876 beta subunit interaction interface [polypeptide binding]; other site 683837007877 Walker A motif; other site 683837007878 ATP binding site [chemical binding]; other site 683837007879 Walker B motif; other site 683837007880 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 683837007881 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 683837007882 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 683837007883 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 683837007884 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 683837007885 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 683837007886 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 683837007887 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 683837007888 ATP synthase I chain; Region: ATP_synt_I; pfam03899 683837007889 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 683837007890 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 683837007891 active site 683837007892 homodimer interface [polypeptide binding]; other site 683837007893 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 683837007894 active site 683837007895 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 683837007896 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 683837007897 dimer interface [polypeptide binding]; other site 683837007898 active site 683837007899 glycine-pyridoxal phosphate binding site [chemical binding]; other site 683837007900 folate binding site [chemical binding]; other site 683837007901 Low molecular weight phosphatase family; Region: LMWPc; cd00115 683837007902 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 683837007903 active site 683837007904 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 683837007905 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 683837007906 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 683837007907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837007908 S-adenosylmethionine binding site [chemical binding]; other site 683837007909 peptide chain release factor 1; Validated; Region: prfA; PRK00591 683837007910 This domain is found in peptide chain release factors; Region: PCRF; smart00937 683837007911 RF-1 domain; Region: RF-1; pfam00472 683837007912 thymidine kinase; Provisional; Region: PRK04296 683837007913 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 683837007914 ATP binding site [chemical binding]; other site 683837007915 Walker A motif; other site 683837007916 Walker B motif; other site 683837007917 homoserine kinase; Provisional; Region: PRK01212 683837007918 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 683837007919 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 683837007920 threonine synthase; Reviewed; Region: PRK06721 683837007921 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 683837007922 homodimer interface [polypeptide binding]; other site 683837007923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837007924 catalytic residue [active] 683837007925 homoserine dehydrogenase; Provisional; Region: PRK06349 683837007926 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 683837007927 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 683837007928 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 683837007929 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 683837007930 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 683837007931 DNA binding residues [nucleotide binding] 683837007932 putative dimer interface [polypeptide binding]; other site 683837007933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837007934 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837007935 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 683837007936 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 683837007937 Transcriptional regulator [Transcription]; Region: LysR; COG0583 683837007938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 683837007939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 683837007940 dimerization interface [polypeptide binding]; other site 683837007941 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 683837007942 Predicted membrane protein [Function unknown]; Region: COG2246 683837007943 GtrA-like protein; Region: GtrA; pfam04138 683837007944 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 683837007945 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 683837007946 Ligand binding site; other site 683837007947 Putative Catalytic site; other site 683837007948 DXD motif; other site 683837007949 transcription termination factor Rho; Provisional; Region: rho; PRK09376 683837007950 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 683837007951 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 683837007952 RNA binding site [nucleotide binding]; other site 683837007953 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 683837007954 multimer interface [polypeptide binding]; other site 683837007955 Walker A motif; other site 683837007956 ATP binding site [chemical binding]; other site 683837007957 Walker B motif; other site 683837007958 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 683837007959 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 683837007960 hinge; other site 683837007961 active site 683837007962 Predicted integral membrane protein [Function unknown]; Region: COG0392 683837007963 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 683837007964 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 683837007965 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 683837007966 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 683837007967 putative ADP-binding pocket [chemical binding]; other site 683837007968 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 683837007969 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 683837007970 intersubunit interface [polypeptide binding]; other site 683837007971 active site 683837007972 zinc binding site [ion binding]; other site 683837007973 Na+ binding site [ion binding]; other site 683837007974 putative lipid kinase; Reviewed; Region: PRK13055 683837007975 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 683837007976 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 683837007977 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 683837007978 amidase catalytic site [active] 683837007979 Zn binding residues [ion binding]; other site 683837007980 substrate binding site [chemical binding]; other site 683837007981 SH3-like domain; Region: SH3_8; pfam13457 683837007982 SH3-like domain; Region: SH3_8; pfam13457 683837007983 SH3-like domain; Region: SH3_8; pfam13457 683837007984 SH3-like domain; Region: SH3_8; pfam13457 683837007985 SH3-like domain; Region: SH3_8; pfam13457 683837007986 CTP synthetase; Validated; Region: pyrG; PRK05380 683837007987 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 683837007988 Catalytic site [active] 683837007989 active site 683837007990 UTP binding site [chemical binding]; other site 683837007991 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 683837007992 active site 683837007993 putative oxyanion hole; other site 683837007994 catalytic triad [active] 683837007995 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 683837007996 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 683837007997 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 683837007998 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 683837007999 active site 683837008000 HIGH motif; other site 683837008001 KMSK motif region; other site 683837008002 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 683837008003 tRNA binding surface [nucleotide binding]; other site 683837008004 anticodon binding site; other site 683837008005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 683837008006 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 683837008007 Peptidase family M50; Region: Peptidase_M50; pfam02163 683837008008 active site 683837008009 putative substrate binding region [chemical binding]; other site 683837008010 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 683837008011 active site 1 [active] 683837008012 dimer interface [polypeptide binding]; other site 683837008013 hexamer interface [polypeptide binding]; other site 683837008014 active site 2 [active] 683837008015 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 683837008016 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 683837008017 Zn2+ binding site [ion binding]; other site 683837008018 Mg2+ binding site [ion binding]; other site 683837008019 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 683837008020 conserved hypothetical protein TIGR01655; Region: yxeA_fam 683837008021 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 683837008022 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 683837008023 peptide binding site [polypeptide binding]; other site 683837008024 Predicted integral membrane protein [Function unknown]; Region: COG5658 683837008025 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 683837008026 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 683837008027 catalytic triad [active] 683837008028 metal binding site [ion binding]; metal-binding site 683837008029 conserved cis-peptide bond; other site 683837008030 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 683837008031 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 683837008032 folate binding site [chemical binding]; other site 683837008033 NADP+ binding site [chemical binding]; other site 683837008034 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 683837008035 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 683837008036 putative NAD(P) binding site [chemical binding]; other site 683837008037 dimer interface [polypeptide binding]; other site 683837008038 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 683837008039 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 683837008040 Collagen binding domain; Region: Collagen_bind; pfam05737 683837008041 Collagen binding domain; Region: Collagen_bind; pfam05737 683837008042 Collagen binding domain; Region: Collagen_bind; pfam05737 683837008043 Cna protein B-type domain; Region: Cna_B; pfam05738 683837008044 Cna protein B-type domain; Region: Cna_B; pfam05738 683837008045 Cna protein B-type domain; Region: Cna_B; pfam05738 683837008046 Cna protein B-type domain; Region: Cna_B; pfam05738 683837008047 Cna protein B-type domain; Region: Cna_B; pfam05738 683837008048 Cna protein B-type domain; Region: Cna_B; pfam05738 683837008049 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 683837008050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837008051 active site 683837008052 motif I; other site 683837008053 motif II; other site 683837008054 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 683837008055 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 683837008056 Uncharacterized conserved protein [Function unknown]; Region: COG2427 683837008057 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 683837008058 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 683837008059 catalytic loop [active] 683837008060 iron binding site [ion binding]; other site 683837008061 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 683837008062 4Fe-4S binding domain; Region: Fer4; pfam00037 683837008063 4Fe-4S binding domain; Region: Fer4; pfam00037 683837008064 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 683837008065 [4Fe-4S] binding site [ion binding]; other site 683837008066 molybdopterin cofactor binding site; other site 683837008067 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 683837008068 molybdopterin cofactor binding site; other site 683837008069 Uncharacterized conserved protein [Function unknown]; Region: COG1912 683837008070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837008071 putative substrate translocation pore; other site 683837008072 Protein of unknown function (DUF983); Region: DUF983; cl02211 683837008073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 683837008074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 683837008075 antiporter inner membrane protein; Provisional; Region: PRK11670 683837008076 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 683837008077 Walker A motif; other site 683837008078 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 683837008079 SH3-like domain; Region: SH3_8; pfam13457 683837008080 SH3-like domain; Region: SH3_8; pfam13457 683837008081 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 683837008082 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 683837008083 putative NAD(P) binding site [chemical binding]; other site 683837008084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837008085 ABC transporter signature motif; other site 683837008086 Walker B; other site 683837008087 D-loop; other site 683837008088 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837008089 non-specific DNA binding site [nucleotide binding]; other site 683837008090 salt bridge; other site 683837008091 sequence-specific DNA binding site [nucleotide binding]; other site 683837008092 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 683837008093 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 683837008094 23S rRNA interface [nucleotide binding]; other site 683837008095 L3 interface [polypeptide binding]; other site 683837008096 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 683837008097 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 683837008098 dimerization interface 3.5A [polypeptide binding]; other site 683837008099 active site 683837008100 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 683837008101 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 683837008102 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 683837008103 Walker A/P-loop; other site 683837008104 ATP binding site [chemical binding]; other site 683837008105 Q-loop/lid; other site 683837008106 ABC transporter signature motif; other site 683837008107 Walker B; other site 683837008108 D-loop; other site 683837008109 H-loop/switch region; other site 683837008110 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 683837008111 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 683837008112 Walker A/P-loop; other site 683837008113 ATP binding site [chemical binding]; other site 683837008114 Q-loop/lid; other site 683837008115 ABC transporter signature motif; other site 683837008116 Walker B; other site 683837008117 D-loop; other site 683837008118 H-loop/switch region; other site 683837008119 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 683837008120 MgtC family; Region: MgtC; pfam02308 683837008121 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 683837008122 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 683837008123 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 683837008124 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 683837008125 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 683837008126 alphaNTD - beta interaction site [polypeptide binding]; other site 683837008127 alphaNTD homodimer interface [polypeptide binding]; other site 683837008128 alphaNTD - beta' interaction site [polypeptide binding]; other site 683837008129 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 683837008130 30S ribosomal protein S11; Validated; Region: PRK05309 683837008131 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 683837008132 30S ribosomal protein S13; Region: bact_S13; TIGR03631 683837008133 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 683837008134 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 683837008135 rRNA binding site [nucleotide binding]; other site 683837008136 predicted 30S ribosome binding site; other site 683837008137 adenylate kinase; Reviewed; Region: adk; PRK00279 683837008138 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 683837008139 AMP-binding site [chemical binding]; other site 683837008140 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 683837008141 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 683837008142 SecY translocase; Region: SecY; pfam00344 683837008143 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 683837008144 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 683837008145 23S rRNA binding site [nucleotide binding]; other site 683837008146 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 683837008147 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 683837008148 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 683837008149 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 683837008150 5S rRNA interface [nucleotide binding]; other site 683837008151 L27 interface [polypeptide binding]; other site 683837008152 23S rRNA interface [nucleotide binding]; other site 683837008153 L5 interface [polypeptide binding]; other site 683837008154 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 683837008155 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 683837008156 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 683837008157 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 683837008158 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 683837008159 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 683837008160 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 683837008161 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 683837008162 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 683837008163 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 683837008164 RNA binding site [nucleotide binding]; other site 683837008165 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 683837008166 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 683837008167 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 683837008168 23S rRNA interface [nucleotide binding]; other site 683837008169 putative translocon interaction site; other site 683837008170 signal recognition particle (SRP54) interaction site; other site 683837008171 L23 interface [polypeptide binding]; other site 683837008172 trigger factor interaction site; other site 683837008173 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 683837008174 23S rRNA interface [nucleotide binding]; other site 683837008175 5S rRNA interface [nucleotide binding]; other site 683837008176 putative antibiotic binding site [chemical binding]; other site 683837008177 L25 interface [polypeptide binding]; other site 683837008178 L27 interface [polypeptide binding]; other site 683837008179 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 683837008180 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 683837008181 G-X-X-G motif; other site 683837008182 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 683837008183 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 683837008184 putative translocon binding site; other site 683837008185 protein-rRNA interface [nucleotide binding]; other site 683837008186 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 683837008187 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 683837008188 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 683837008189 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 683837008190 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 683837008191 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 683837008192 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 683837008193 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 683837008194 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 683837008195 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 683837008196 UbiA prenyltransferase family; Region: UbiA; pfam01040 683837008197 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 683837008198 ApbE family; Region: ApbE; pfam02424 683837008199 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 683837008200 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 683837008201 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 683837008202 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 683837008203 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 683837008204 Predicted membrane protein [Function unknown]; Region: COG2259 683837008205 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 683837008206 trimer interface [polypeptide binding]; other site 683837008207 Predicted membrane protein [Function unknown]; Region: COG4769 683837008208 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 683837008209 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 683837008210 substrate binding pocket [chemical binding]; other site 683837008211 chain length determination region; other site 683837008212 substrate-Mg2+ binding site; other site 683837008213 catalytic residues [active] 683837008214 aspartate-rich region 1; other site 683837008215 active site lid residues [active] 683837008216 aspartate-rich region 2; other site 683837008217 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 683837008218 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 683837008219 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 683837008220 hypothetical protein; Provisional; Region: PRK02947 683837008221 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 683837008222 putative active site [active] 683837008223 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 683837008224 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 683837008225 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 683837008226 active site 683837008227 substrate binding pocket [chemical binding]; other site 683837008228 homodimer interaction site [polypeptide binding]; other site 683837008229 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 683837008230 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 683837008231 active site 683837008232 P-loop; other site 683837008233 phosphorylation site [posttranslational modification] 683837008234 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 683837008235 active site 683837008236 phosphorylation site [posttranslational modification] 683837008237 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 683837008238 Mga helix-turn-helix domain; Region: Mga; pfam05043 683837008239 PRD domain; Region: PRD; pfam00874 683837008240 PRD domain; Region: PRD; pfam00874 683837008241 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 683837008242 active site 683837008243 P-loop; other site 683837008244 phosphorylation site [posttranslational modification] 683837008245 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 683837008246 active site 683837008247 phosphorylation site [posttranslational modification] 683837008248 elongation factor Tu; Reviewed; Region: PRK00049 683837008249 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 683837008250 G1 box; other site 683837008251 GEF interaction site [polypeptide binding]; other site 683837008252 GTP/Mg2+ binding site [chemical binding]; other site 683837008253 Switch I region; other site 683837008254 G2 box; other site 683837008255 G3 box; other site 683837008256 Switch II region; other site 683837008257 G4 box; other site 683837008258 G5 box; other site 683837008259 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 683837008260 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 683837008261 Antibiotic Binding Site [chemical binding]; other site 683837008262 elongation factor G; Reviewed; Region: PRK00007 683837008263 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 683837008264 G1 box; other site 683837008265 putative GEF interaction site [polypeptide binding]; other site 683837008266 GTP/Mg2+ binding site [chemical binding]; other site 683837008267 Switch I region; other site 683837008268 G2 box; other site 683837008269 G3 box; other site 683837008270 Switch II region; other site 683837008271 G4 box; other site 683837008272 G5 box; other site 683837008273 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 683837008274 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 683837008275 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 683837008276 30S ribosomal protein S7; Validated; Region: PRK05302 683837008277 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 683837008278 S17 interaction site [polypeptide binding]; other site 683837008279 S8 interaction site; other site 683837008280 16S rRNA interaction site [nucleotide binding]; other site 683837008281 streptomycin interaction site [chemical binding]; other site 683837008282 23S rRNA interaction site [nucleotide binding]; other site 683837008283 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 683837008284 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 683837008285 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 683837008286 Zn2+ binding site [ion binding]; other site 683837008287 Mg2+ binding site [ion binding]; other site 683837008288 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 683837008289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 683837008290 Coenzyme A binding pocket [chemical binding]; other site 683837008291 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 683837008292 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 683837008293 substrate binding site [chemical binding]; other site 683837008294 hexamer interface [polypeptide binding]; other site 683837008295 metal binding site [ion binding]; metal-binding site 683837008296 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 683837008297 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 683837008298 TPP-binding site [chemical binding]; other site 683837008299 dimer interface [polypeptide binding]; other site 683837008300 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 683837008301 PYR/PP interface [polypeptide binding]; other site 683837008302 dimer interface [polypeptide binding]; other site 683837008303 TPP binding site [chemical binding]; other site 683837008304 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 683837008305 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 683837008306 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 683837008307 substrate binding site [chemical binding]; other site 683837008308 hexamer interface [polypeptide binding]; other site 683837008309 metal binding site [ion binding]; metal-binding site 683837008310 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 683837008311 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 683837008312 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 683837008313 putative NAD(P) binding site [chemical binding]; other site 683837008314 catalytic Zn binding site [ion binding]; other site 683837008315 structural Zn binding site [ion binding]; other site 683837008316 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 683837008317 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 683837008318 putative NAD(P) binding site [chemical binding]; other site 683837008319 catalytic Zn binding site [ion binding]; other site 683837008320 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 683837008321 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 683837008322 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 683837008323 active site 683837008324 P-loop; other site 683837008325 phosphorylation site [posttranslational modification] 683837008326 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 683837008327 active site 683837008328 phosphorylation site [posttranslational modification] 683837008329 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 683837008330 PRD domain; Region: PRD; pfam00874 683837008331 PRD domain; Region: PRD; pfam00874 683837008332 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 683837008333 active site 683837008334 P-loop; other site 683837008335 phosphorylation site [posttranslational modification] 683837008336 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 683837008337 active site 683837008338 phosphorylation site [posttranslational modification] 683837008339 Predicted membrane protein [Function unknown]; Region: COG4905 683837008340 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 683837008341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 683837008342 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 683837008343 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 683837008344 active site 683837008345 Helix-turn-helix domain; Region: HTH_18; pfam12833 683837008346 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 683837008347 Ligand Binding Site [chemical binding]; other site 683837008348 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 683837008349 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 683837008350 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 683837008351 DNA polymerase IV; Reviewed; Region: PRK03103 683837008352 active site 683837008353 DNA binding site [nucleotide binding] 683837008354 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 683837008355 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 683837008356 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 683837008357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 683837008358 active site 683837008359 phosphorylation site [posttranslational modification] 683837008360 intermolecular recognition site; other site 683837008361 dimerization interface [polypeptide binding]; other site 683837008362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 683837008363 DNA binding site [nucleotide binding] 683837008364 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 683837008365 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 683837008366 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 683837008367 Ligand Binding Site [chemical binding]; other site 683837008368 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 683837008369 GAF domain; Region: GAF_3; pfam13492 683837008370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 683837008371 dimer interface [polypeptide binding]; other site 683837008372 phosphorylation site [posttranslational modification] 683837008373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 683837008374 ATP binding site [chemical binding]; other site 683837008375 Mg2+ binding site [ion binding]; other site 683837008376 G-X-G motif; other site 683837008377 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 683837008378 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 683837008379 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 683837008380 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 683837008381 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 683837008382 active site 683837008383 P-loop; other site 683837008384 phosphorylation site [posttranslational modification] 683837008385 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 683837008386 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 683837008387 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 683837008388 methionine cluster; other site 683837008389 active site 683837008390 phosphorylation site [posttranslational modification] 683837008391 metal binding site [ion binding]; metal-binding site 683837008392 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 683837008393 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 683837008394 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 683837008395 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 683837008396 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 683837008397 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 683837008398 Soluble P-type ATPase [General function prediction only]; Region: COG4087 683837008399 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 683837008400 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 683837008401 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 683837008402 autolysin; Reviewed; Region: PRK06347 683837008403 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 683837008404 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 683837008405 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 683837008406 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 683837008407 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 683837008408 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 683837008409 Protein of unknown function (DUF970); Region: DUF970; pfam06153 683837008410 thymidylate kinase; Validated; Region: tmk; PRK00698 683837008411 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 683837008412 TMP-binding site; other site 683837008413 ATP-binding site [chemical binding]; other site 683837008414 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 683837008415 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 683837008416 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 683837008417 catalytic residue [active] 683837008418 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 683837008419 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 683837008420 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 683837008421 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 683837008422 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 683837008423 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 683837008424 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 683837008425 shikimate kinase; Provisional; Region: PRK00625 683837008426 hypothetical protein; Provisional; Region: PLN03150 683837008427 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 683837008428 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 683837008429 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 683837008430 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 683837008431 putative active site [active] 683837008432 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 683837008433 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837008434 active site 683837008435 motif I; other site 683837008436 motif II; other site 683837008437 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 683837008438 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 683837008439 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837008440 Leucine rich repeat; Region: LRR_8; pfam13855 683837008441 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 683837008442 LRR adjacent; Region: LRR_adjacent; pfam08191 683837008443 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 683837008444 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 683837008445 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 683837008446 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 683837008447 active site 683837008448 catalytic tetrad [active] 683837008449 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 683837008450 active site 683837008451 methionine cluster; other site 683837008452 phosphorylation site [posttranslational modification] 683837008453 metal binding site [ion binding]; metal-binding site 683837008454 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 683837008455 beta-galactosidase; Region: BGL; TIGR03356 683837008456 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 683837008457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837008458 active site 683837008459 motif I; other site 683837008460 motif II; other site 683837008461 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 683837008462 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 683837008463 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 683837008464 active site 683837008465 catalytic site [active] 683837008466 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 683837008467 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 683837008468 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 683837008469 active site 683837008470 P-loop; other site 683837008471 phosphorylation site [posttranslational modification] 683837008472 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 683837008473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 683837008474 DNA-binding site [nucleotide binding]; DNA binding site 683837008475 UTRA domain; Region: UTRA; pfam07702 683837008476 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 683837008477 recombination protein RecR; Reviewed; Region: recR; PRK00076 683837008478 RecR protein; Region: RecR; pfam02132 683837008479 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 683837008480 putative active site [active] 683837008481 putative metal-binding site [ion binding]; other site 683837008482 tetramer interface [polypeptide binding]; other site 683837008483 hypothetical protein; Validated; Region: PRK00153 683837008484 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 683837008485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 683837008486 Walker A motif; other site 683837008487 ATP binding site [chemical binding]; other site 683837008488 Walker B motif; other site 683837008489 arginine finger; other site 683837008490 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 683837008491 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 683837008492 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 683837008493 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 683837008494 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 683837008495 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 683837008496 N- and C-terminal domain interface [polypeptide binding]; other site 683837008497 active site 683837008498 catalytic site [active] 683837008499 metal binding site [ion binding]; metal-binding site 683837008500 carbohydrate binding site [chemical binding]; other site 683837008501 ATP binding site [chemical binding]; other site 683837008502 SH3-like domain; Region: SH3_8; pfam13457 683837008503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 683837008504 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 683837008505 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 683837008506 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 683837008507 Walker A/P-loop; other site 683837008508 ATP binding site [chemical binding]; other site 683837008509 Q-loop/lid; other site 683837008510 ABC transporter signature motif; other site 683837008511 Walker B; other site 683837008512 D-loop; other site 683837008513 H-loop/switch region; other site 683837008514 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 683837008515 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 683837008516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837008517 Walker A/P-loop; other site 683837008518 ATP binding site [chemical binding]; other site 683837008519 Q-loop/lid; other site 683837008520 ABC transporter signature motif; other site 683837008521 Walker B; other site 683837008522 D-loop; other site 683837008523 H-loop/switch region; other site 683837008524 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 683837008525 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 683837008526 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 683837008527 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 683837008528 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 683837008529 nucleoside/Zn binding site; other site 683837008530 dimer interface [polypeptide binding]; other site 683837008531 catalytic motif [active] 683837008532 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 683837008533 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 683837008534 active site 683837008535 acyl-activating enzyme (AAE) consensus motif; other site 683837008536 putative CoA binding site [chemical binding]; other site 683837008537 AMP binding site [chemical binding]; other site 683837008538 LXG domain of WXG superfamily; Region: LXG; pfam04740 683837008539 IncA protein; Region: IncA; pfam04156 683837008540 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 683837008541 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 683837008542 active site 683837008543 trimer interface [polypeptide binding]; other site 683837008544 allosteric site; other site 683837008545 active site lid [active] 683837008546 hexamer (dimer of trimers) interface [polypeptide binding]; other site 683837008547 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 683837008548 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 683837008549 DNA binding residues [nucleotide binding] 683837008550 drug binding residues [chemical binding]; other site 683837008551 dimer interface [polypeptide binding]; other site 683837008552 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 683837008553 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 683837008554 Coenzyme A binding pocket [chemical binding]; other site 683837008555 Phosphotransferase enzyme family; Region: APH; pfam01636 683837008556 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 683837008557 active site 683837008558 ATP binding site [chemical binding]; other site 683837008559 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 683837008560 dimer interface [polypeptide binding]; other site 683837008561 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 683837008562 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 683837008563 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 683837008564 MarR family; Region: MarR; pfam01047 683837008565 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 683837008566 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 683837008567 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 683837008568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 683837008569 NAD(P) binding site [chemical binding]; other site 683837008570 active site 683837008571 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 683837008572 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 683837008573 DNA binding residues [nucleotide binding] 683837008574 putative dimer interface [polypeptide binding]; other site 683837008575 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 683837008576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837008577 motif II; other site 683837008578 Transcriptional regulators [Transcription]; Region: PurR; COG1609 683837008579 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 683837008580 DNA binding site [nucleotide binding] 683837008581 domain linker motif; other site 683837008582 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 683837008583 putative dimerization interface [polypeptide binding]; other site 683837008584 putative ligand binding site [chemical binding]; other site 683837008585 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 683837008586 Domain of unknown function DUF21; Region: DUF21; pfam01595 683837008587 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 683837008588 Transporter associated domain; Region: CorC_HlyC; pfam03471 683837008589 NAD-dependent deacetylase; Provisional; Region: PRK00481 683837008590 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 683837008591 NAD+ binding site [chemical binding]; other site 683837008592 substrate binding site [chemical binding]; other site 683837008593 putative Zn binding site [ion binding]; other site 683837008594 Pathogenicity locus; Region: Cdd1; pfam11731 683837008595 drug efflux system protein MdtG; Provisional; Region: PRK09874 683837008596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837008597 putative substrate translocation pore; other site 683837008598 Src Homology 3 domain superfamily; Region: SH3; cl17036 683837008599 Variant SH3 domain; Region: SH3_2; pfam07653 683837008600 peptide ligand binding site [polypeptide binding]; other site 683837008601 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 683837008602 active site 683837008603 intersubunit interactions; other site 683837008604 catalytic residue [active] 683837008605 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 683837008606 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 683837008607 ligand binding site [chemical binding]; other site 683837008608 flexible hinge region; other site 683837008609 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 683837008610 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 683837008611 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 683837008612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837008613 Walker A/P-loop; other site 683837008614 ATP binding site [chemical binding]; other site 683837008615 Q-loop/lid; other site 683837008616 ABC transporter signature motif; other site 683837008617 Walker B; other site 683837008618 D-loop; other site 683837008619 H-loop/switch region; other site 683837008620 TfoX C-terminal domain; Region: TfoX_C; pfam04994 683837008621 seryl-tRNA synthetase; Provisional; Region: PRK05431 683837008622 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 683837008623 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 683837008624 dimer interface [polypeptide binding]; other site 683837008625 active site 683837008626 motif 1; other site 683837008627 motif 2; other site 683837008628 motif 3; other site 683837008629 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 683837008630 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 683837008631 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 683837008632 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 683837008633 glutamine binding [chemical binding]; other site 683837008634 catalytic triad [active] 683837008635 aminodeoxychorismate synthase; Provisional; Region: PRK07508 683837008636 chorismate binding enzyme; Region: Chorismate_bind; cl10555 683837008637 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 683837008638 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 683837008639 substrate-cofactor binding pocket; other site 683837008640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837008641 catalytic residue [active] 683837008642 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 683837008643 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 683837008644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 683837008645 Walker A/P-loop; other site 683837008646 ATP binding site [chemical binding]; other site 683837008647 Q-loop/lid; other site 683837008648 ABC transporter signature motif; other site 683837008649 Walker B; other site 683837008650 D-loop; other site 683837008651 H-loop/switch region; other site 683837008652 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 683837008653 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 683837008654 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 683837008655 Walker A/P-loop; other site 683837008656 ATP binding site [chemical binding]; other site 683837008657 Q-loop/lid; other site 683837008658 ABC transporter signature motif; other site 683837008659 Walker B; other site 683837008660 D-loop; other site 683837008661 H-loop/switch region; other site 683837008662 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 683837008663 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 683837008664 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 683837008665 Predicted acyl esterases [General function prediction only]; Region: COG2936 683837008666 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 683837008667 DNA topoisomerase III; Provisional; Region: PRK07726 683837008668 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 683837008669 active site 683837008670 putative interdomain interaction site [polypeptide binding]; other site 683837008671 putative metal-binding site [ion binding]; other site 683837008672 putative nucleotide binding site [chemical binding]; other site 683837008673 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 683837008674 domain I; other site 683837008675 DNA binding groove [nucleotide binding] 683837008676 phosphate binding site [ion binding]; other site 683837008677 domain II; other site 683837008678 domain III; other site 683837008679 nucleotide binding site [chemical binding]; other site 683837008680 catalytic site [active] 683837008681 domain IV; other site 683837008682 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 683837008683 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 683837008684 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 683837008685 ATP binding site [chemical binding]; other site 683837008686 putative Mg++ binding site [ion binding]; other site 683837008687 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 683837008688 nucleotide binding region [chemical binding]; other site 683837008689 ATP-binding site [chemical binding]; other site 683837008690 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 683837008691 HRDC domain; Region: HRDC; pfam00570 683837008692 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 683837008693 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 683837008694 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 683837008695 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 683837008696 active site 683837008697 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 683837008698 putative ADP-ribose binding site [chemical binding]; other site 683837008699 putative active site [active] 683837008700 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 683837008701 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 683837008702 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 683837008703 ABC transporter; Region: ABC_tran_2; pfam12848 683837008704 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 683837008705 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 683837008706 beta-galactosidase; Region: BGL; TIGR03356 683837008707 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 683837008708 active site 683837008709 P-loop; other site 683837008710 phosphorylation site [posttranslational modification] 683837008711 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 683837008712 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 683837008713 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 683837008714 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 683837008715 nucleotide binding site [chemical binding]; other site 683837008716 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 683837008717 methionine cluster; other site 683837008718 active site 683837008719 phosphorylation site [posttranslational modification] 683837008720 metal binding site [ion binding]; metal-binding site 683837008721 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 683837008722 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 683837008723 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 683837008724 putative active site [active] 683837008725 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 683837008726 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 683837008727 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 683837008728 Walker A/P-loop; other site 683837008729 ATP binding site [chemical binding]; other site 683837008730 Q-loop/lid; other site 683837008731 ABC transporter signature motif; other site 683837008732 Walker B; other site 683837008733 D-loop; other site 683837008734 H-loop/switch region; other site 683837008735 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 683837008736 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 683837008737 ATP-grasp domain; Region: ATP-grasp_4; cl17255 683837008738 GTP-binding protein YchF; Reviewed; Region: PRK09601 683837008739 YchF GTPase; Region: YchF; cd01900 683837008740 G1 box; other site 683837008741 GTP/Mg2+ binding site [chemical binding]; other site 683837008742 Switch I region; other site 683837008743 G2 box; other site 683837008744 Switch II region; other site 683837008745 G3 box; other site 683837008746 G4 box; other site 683837008747 G5 box; other site 683837008748 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 683837008749 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 683837008750 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 683837008751 tetramer interface [polypeptide binding]; other site 683837008752 heme binding pocket [chemical binding]; other site 683837008753 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 683837008754 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 683837008755 ParB-like nuclease domain; Region: ParB; smart00470 683837008756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837008757 salt bridge; other site 683837008758 non-specific DNA binding site [nucleotide binding]; other site 683837008759 sequence-specific DNA binding site [nucleotide binding]; other site 683837008760 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 683837008761 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 683837008762 P-loop; other site 683837008763 Magnesium ion binding site [ion binding]; other site 683837008764 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 683837008765 Magnesium ion binding site [ion binding]; other site 683837008766 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 683837008767 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 683837008768 non-specific DNA binding site [nucleotide binding]; other site 683837008769 salt bridge; other site 683837008770 sequence-specific DNA binding site [nucleotide binding]; other site 683837008771 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 683837008772 ParB-like nuclease domain; Region: ParBc; pfam02195 683837008773 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 683837008774 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 683837008775 putative active site cavity [active] 683837008776 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 683837008777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 683837008778 S-adenosylmethionine binding site [chemical binding]; other site 683837008779 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 683837008780 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 683837008781 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 683837008782 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 683837008783 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 683837008784 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 683837008785 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 683837008786 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 683837008787 trmE is a tRNA modification GTPase; Region: trmE; cd04164 683837008788 G1 box; other site 683837008789 GTP/Mg2+ binding site [chemical binding]; other site 683837008790 Switch I region; other site 683837008791 G2 box; other site 683837008792 Switch II region; other site 683837008793 G3 box; other site 683837008794 G4 box; other site 683837008795 G5 box; other site 683837008796 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 683837008797 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 683837008798 Collagen binding domain; Region: Collagen_bind; pfam05737 683837008799 Collagen binding domain; Region: Collagen_bind; pfam05737 683837008800 Collagen binding domain; Region: Collagen_bind; pfam05737 683837008801 Cna protein B-type domain; Region: Cna_B; pfam05738 683837008802 Cna protein B-type domain; Region: Cna_B; pfam05738 683837008803 Cna protein B-type domain; Region: Cna_B; pfam05738 683837008804 Cna protein B-type domain; Region: Cna_B; pfam05738 683837008805 Uncharacterized conserved protein [Function unknown]; Region: COG4198 683837008806 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 683837008807 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 683837008808 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 683837008809 putative ligand binding site [chemical binding]; other site 683837008810 putative NAD binding site [chemical binding]; other site 683837008811 putative catalytic site [active] 683837008812 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 683837008813 L-serine binding site [chemical binding]; other site 683837008814 ACT domain interface; other site 683837008815 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 683837008816 homodimer interface [polypeptide binding]; other site 683837008817 substrate-cofactor binding pocket; other site 683837008818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 683837008819 catalytic residue [active] 683837008820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837008821 Major Facilitator Superfamily; Region: MFS_1; pfam07690 683837008822 putative substrate translocation pore; other site 683837008823 Transcriptional regulators [Transcription]; Region: MarR; COG1846 683837008824 MarR family; Region: MarR_2; pfam12802 683837008825 MarR family; Region: MarR_2; cl17246 683837008826 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 683837008827 dimer interface [polypeptide binding]; other site 683837008828 FMN binding site [chemical binding]; other site 683837008829 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 683837008830 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 683837008831 catalytic residues [active] 683837008832 beta-phosphoglucomutase; Region: bPGM; TIGR01990 683837008833 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 683837008834 motif II; other site 683837008835 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 683837008836 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 683837008837 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 683837008838 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 683837008839 Coenzyme A binding pocket [chemical binding]; other site 683837008840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 683837008841 putative transporter; Provisional; Region: PRK10504 683837008842 putative substrate translocation pore; other site 683837008843 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 683837008844 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 683837008845 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 683837008846 G-X-X-G motif; other site 683837008847 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 683837008848 RxxxH motif; other site 683837008849 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 683837008850 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 683837008851 ribonuclease P; Reviewed; Region: rnpA; PRK00499 683837008852 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399